This Week in Virology

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TWiV is a weekly netcast about viruses - the kind that make you sick. Professors Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler and science writer Alan Dove and guests deconstruct viruses, how they cause illness, and dissect the latest research.

Vincent Racaniello


    • Oct 24, 2021 LATEST EPISODE
    • weekdays NEW EPISODES
    • 1h 37m AVG DURATION
    • 305 EPISODES

    Listeners of This Week in Virology that love the show mention: twiv, viruses, despommier, twip, immunology, twim, parasitology, molecular, dickson, non scientist, week in virology, journal club, vincent racaniello, condit, twix, racaniello et, week in microbiology, sars cov, accessable, edu tainment.



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    Latest episodes from This Week in Virology

    TWiV 821: Public clonotype #1

    Play Episode Listen Later Oct 24, 2021 120:39

    A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bat and rodent paramyxoviruses from Arizona (J Viral) Naive B cells engage SARS-CoV-2 RBD (Science Immunol) Vincent interviews Philip Sharp (ASM) Letters read on TWiV 821 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Apod: The Dolphin Head Nebula Rich – The Tree That Could Help Stop The Pandemic; Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants Vincent – Discovery of RNA splicing in Sharp and Roberts laboratories Listener Picks Jason – Home Assistant Alena – VirusCraft Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 820: COVID-19 clinical update #85 with Dr. Daniel Griffin

    Play Episode Listen Later Oct 23, 2021 41:20

    In COVID-19 clinical update #85, Dr. Griffin reviews cases and deaths by vaccination status, mRNA vaccine effectiveness in 12-18 year olds, standard and extended dosing of mRNA vaccines, immune responses after vaccination, Moderna booster dose approved, giving monoclonals at home, no benefit from colchicine, and IFN does not help remdesivir. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Guidelines on COVID-19 drugs (WHO) Holiday celebrations (CDC) COVID-19 cases and deaths by vaccination status (CDC) Effectiveness of Pfizer-BioNTech mRNA Vaccination 12-18 years (MMWR) Rollout of vaccines for 5-11 year olds (WaPo) Standard and extended dosing mRNA vaccine (Cell) Differential kinetics immune responses after vaccination (NEJM) Moderna booster dose approved (FDA) Vertically transferred maternal immune cells (Nat Comm) Giving monoclonals at home (JAMA) No benefit from colchicine (Lancet) IFN does not help remdesivir (JAMA) Letters read on TWiV 820 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 819: How to stall a copy machine

    Play Episode Listen Later Oct 21, 2021 100:32

    TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How remdesivir stalls the SARS-CoV-2 polymerase (Nat Comm) Movie of polymerase stalling (Nat Comm) Second mechanism of remdesivir inhibition (J Biol Chem) Watson Crick molecular model (Science Museum Group) Letters read on TWiV 819 Timestamps by Jolene. Thanks! Weekly Picks Kathy – Great Lakes Science Center, Cleveland Rich – How to Temporarily Disable Your Keyboard with a Keyboard Shortcut in Windows Alan – How to Make a Slave and Other Essays by Jerald Walker Vincent – A structure for deoxyribose nucleic acid Listener Picks Steve – How the immune system actually works Lise – Lise Meitner: A Life in Physics Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 818: Thor's hammer

    Play Episode Listen Later Oct 17, 2021 116:19

    The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Efficacy and safety of Novavax vaccine (medRxiv) A floret of spikes with Matt Frieman (TWiV 729) Maternal SARS-CoV-2 infection affects neonatal immunity (Nat Immunol) NHC is mutagenic in mammalian cells (J Inf Dis) Coding for catastrophe (Nat Struct Mol Biol) Molnupiravir development (Nature) Letters read on TWiV 818 Timestamps by Jolene. Thanks! Weekly Picks Dickson –  John Clease Brianne – Astronomy Picture of the Day: Swirl in the Southern Sky Kathy – Lise Meitner  Statue is at the Humboldt University Rich – Google has the cleanest cloud. Now it's helping other companies go green Vincent – Discovery of reverse transcriptase by Baltimore and Temin Listener Picks Sam – Air Travel Packing List Justin – PFAS: Last Week Tonight with John Oliver and EPA targets greenhouse emissions Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 817: COVID-19 clinical update #84 with Dr. Daniel Griffin

    Play Episode Listen Later Oct 16, 2021 45:51

    In COVID-19 clinical update #84, Dr. Griffin discusses childrens' antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for molnupiravir, phase 3 results of AZD7442, serum ferritin levels and outcomes, heparin therapy, and WHO strategy for global vaccination. Hosts: Daniel Griffin and Vincent Racaniello   Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Antibody profiles after mRNA vaccination in children (bioRxiv) Novavax vaccine phase 3 results (medRxiv) Heterologous vaccine boosters (medRxiv) Antithrombotic therapy outcomes (JAMA) Molnupiravir EUA submitted (Merck) AZD7442 phase 3 results (AstraZeneca) Serum ferritin levels and disease outcome (JAMA) Heparin efficacy (JAMA) WHO strategy to vaccinate world (WHO) Letters read on TWiV 817 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 816: Long COVID and ME/CFS with David Tuller

    Play Episode Listen Later Oct 15, 2021 69:38

    David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Call me David Tuller (TWiV Special) David writes at virology blog Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar

    Play Episode Listen Later Oct 10, 2021 122:51

    Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler Guests: Moshe Arditi and Ivet Behar Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MIS-C in US children (NEJM) Superantigen in spike and T cell skewing in MIS-C (PNAS) MIS-C mimics toxic shock syndrome (J Allergy Clin Immunol) Antibody against bacterial superantigen blocks SARS-CoV-2 entry (Structure) Autoimmune signature of MIS-C in children (J Clin Invest) HLA1 associated T cell expansion in MIS-C (J Clin Invest) Passing of Bill Wold (one, two) Letters read on TWiV 815 Timestamps by Jolene. Thanks! Weekly Picks Dickson –  Mel Brooks Kathy – Dickson's art show at Fordham Rich – Saildrone captures footage from inside Hurricane Sam Vincent – A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman Listener Picks Kathryn – Project Drawdown and the book Charles – Arrowsmith by Sinclair Lewis Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 814: COVID-19 clinical update #83 with Dr. Daniel Griffin

    Play Episode Listen Later Oct 9, 2021 49:49

    In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccination on transmission, AZD7442 request for EUA filed, EUA issued for home antigen test, phase 3 data on AZD1222 vaccine, 6 month effectiveness of Pfizer/BioNTech vaccine, estimates of durability of immunity against reinfection, Molnupiravir interim results, optimal time for monoclonal antibody infusion, IVIG plus Infliximab for MIS-C, and effect of vaccination on long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Preventing transmission at camps (MMWR) Outbreaks at summer camps (MMWR) Impact of vaccination on transmission (medRxiv) AZD7442 request for FDA EUA (AstraZeneca) FDA EUA for home antigen test (FDA) Phase 3 results AZD1222 vaccine (NEJM) 6 month effectiveness BNT1`62b2 vaccine (Lancet) Durability of immunity vs reinfection (Lancet) Molnupiravir interim results (Merck) Optimal time for mAb therapy (Inf Dis Advisor) IVIG plus Infliximab for MIS-C (Pediatrics) Effect of vaccination on long COVID (Lancet preprint) Letters read on TWiV 814 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 813: COVID-19 at the European Society for Clinical Virology

    Play Episode Listen Later Oct 7, 2021 119:47

    From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one. Host: Vincent Racaniello Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Simian adenoviruses as vaccine vectors (Future Viral) Early SARS-CoV-2 spread in Lombardy (Nat Comm) SARS-CoV-2 seroprevalence in Denmark (Clin Micro Inf) SARS-CoV-2 testing in an academic center (Nat Biotech) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 812: Bespoke capsids delivered

    Play Episode Listen Later Oct 3, 2021 111:38

    TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode   Emergency drug use during a pandemic (Cell) Muscle-directed AAV capsids (Cell) Designer AAV muscles up (Cell) Letters read on TWiV 812 Timestamps by Jolene. Thanks! Weekly Picks Dickson -  Sid Caesar - The German General Brianne - These Sea Slugs Break a Cardinal Rule of Animal Life Rich - Seek by iNaturalist Alan - The hard part of making a game is ... everything Vincent - Columbia Pledges That All Future Campus Construction Will Be Fossil Free Listener Picks Bruce - Bat Superpowers Gary - We're Already Barreling Toward the Next Pandemic Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv  

    TWiV 811: COVID-19 clinical update #82 with Dr. Daniel Griffin

    Play Episode Listen Later Oct 2, 2021 40:26

    In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impact of Tocilizumab, and incidence of long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Data on Pfizer-BioNTech in 5-12 year olds (Pfizer) Safety of additional vaccine dose (MMWR) Oklahoma reinfection rates (OK DOH) Regencov outcomes (NEJM) Pfizer protease inhibitor trial (Pfizer) WHO recommends antibody therapy (Hosp Health) Tocilizumab use in hospitalized patients (Resp Care) Long COVID (PLoS Medicine) Letters read on TWiV 811 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 810: Opening Pandora's box

    Play Episode Listen Later Sep 30, 2021 120:03

    TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode mRNA vaccines, a novel technology (Cell) Proton gradient in giant virus (ISME J) Tomograms of Pandoravirus massiliensis Pandoraviruses are not alive (virology blog) Letters read on TWiV 810 Timestamps by Jolene. Thanks! Weekly Picks Brianne –  PhD Comics: Words Said By No Academic Ever Kathy – Bach Cello Suite #1 visualization Rich – Hypnagogia Vincent – Landsat 9 and Wiki Listener Picks Lori – Project Hail Mary by Andy Weir Kevin – Oak Savannahs Intro music is by Ronald Jenke Send your virology questions and comments to twiv@microbe.tv

    TWiV 809: Vampire vax

    Play Episode Listen Later Sep 26, 2021 99:47

    TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 like viruses from Laotian bats (Res Sq) Herpesvirus in rabies endemic vampire bats (Nat Comm) Letters read on TWiV 809 Timestamps by Jolene. Thanks! Weekly Picks Dickson –  George Carlin: “Stuff” Amy – The best of me by David Sedaris Rich – You could have a secret twin (but not the way you think) Alan – Nuclear powered Gameboy Vincent – No, Vaccinated People Are Not ‘Just as Likely' to Spread the Coronavirus as Unvaccinated People by Craig Spencer Listener Picks Michael – The tangled history mRNA vaccines Fernando – 1493 by Charles Mann Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 808: Clinical update #81 with Dr. Daniel Griffin

    Play Episode Listen Later Sep 25, 2021 51:39

    In COVID-19 clinical update #81, Daniel Griffin discusses vaccine boosters, vaccination during pregnancy, mRNA vaccine comparison, J&J vaccine booster, EUA expansion for Lilly monoclonals, remdesivir reduces risk of hospitalization, and anticoagulation regimens. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pfizer phase III results in 5-11 year olds (Pfizer) FDA authorizes booster (FDA) V-safe vaccine pregnancy registry (CDC) High antibody levels in cord blood (Am J Ob Gyn) mRNA vaccines compared (MMWR) Effectiveness of single shot J&J (medRxiv) J&J booster results (J&J) EUA expansion for Lilly mAbs (Lilly) Remdesivir reduces hospitalization risk (Gilead) DisCoVeRy on Remdesivir (Lancet) Prophylactic anticoagulant dosing (Eur Heart J) Letters read on TWiV 808 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 807: The shot yearned 'round the world with Chadi Saad-Roy and Caroline Wagner

    Play Episode Listen Later Sep 19, 2021 102:04

    Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vaccine distribution for global control of the pandemic. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Brianne Barker Guests: Chadi Saad-Roy and Caroline Wagner Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine nationalism and control of the pandemic (Science) Vaccine sharing app Dynamics of SARS-CoV-2 simulation Dynamics of vaccination simulation Vaccine effectiveness against hospitalization (MMWR) Letters read on TWiV 807 Timestamps by Jolene. Thanks! Weekly Picks Dickson –  Ernie Kovaks-Nairobi Trio Brianne – XKCD Summarizes this Episode Rich – Texas Coronavirus Antibody REsponse Survey (CARES) (Dashboard) Vincent – Elmer Pfefferkorn Listener Picks Catherine – A Life on Our Planet Attila – How to improve your chances of nudging the vaccine hesitant away from hesitancy and toward vaccinationIntro music is by Ronald Jenke Send your virology questions and comments to twiv@microbe.tv

    TWiV 806: COVID-19 clinical update #80 with Dr. Daniel Griffin

    Play Episode Listen Later Sep 18, 2021 49:22

    In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hospitalization pre- and post-vaccines (Res Sq) Infection in children (medRxiv) Updated mask guidance (CDC) Transmission to masked and unmasked (MMWR) Daily testing in schools (Lancet) High barrier to mAb escape (bioRxiv) Boosters not needed (Lancet) Distribution system for mAbs (HHS) Steroids in non-oxygen requiring patients (Int J Med) Grants for long COVID (NIH) Genomic surveillance in Africa (Science) Letters read on TWiV 806 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 805: Delta and boosters

    Play Episode Listen Later Sep 16, 2021 94:10

    The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the SARS-CoV-2 delta variant. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls Vaccine boosters not needed (Lancet) Delta variant replication and immune evasion (Nature) Epidemiologically linked COVID-19 outbreaks (MMWR) Letters read on TWiV 805 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Sloan Foundation Theater Kathy – COVID vaccines work, even if you don't have side effects lay article  primary article Rich – Science Alone Can't Heal a Sick Society by Jay S. Kaufman Vincent – Sandra Black SciArt Listener Pick Ruth – Radio Lento podcast Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 804: A tangled web of viruses with Mya Breitbart

    Play Episode Listen Later Sep 12, 2021 111:12

    Virus hunter Mya Breitbart joins TWiV to describe her laboratory's work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more. Hosts: Vincent Racaniello, Alan Dove, and Dickson Despommier Guest: Mya Breitbart Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Viruses of spinybacked orbweavers (J Gen Virol) Viruses of terrestrial arthropods (PeerJ) Pepper mild mottle virus in sewage (PLoS Path) Environmental DNA in marine community (Nat Comm) Viral community of freshwater springs (mBio) Phage puppet masters in the oceans (Nat Micro) Letters read on TWiV 804 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Official-Droodles-Home Alan – The 31st First Annual Ig Nobel Prize Ceremony video (and the text version) Vincent – Biden's federal and business vaccine mandates Listener Pick Anonymous – The Ivermectin Episode – Behind the Bastards Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 803: COVID-19 clinical update #79 with Dr. Daniel Griffin

    Play Episode Listen Later Sep 11, 2021 45:15

    In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, antibodies in Kenyan blood donors, infections after vaccination, anticoagulation for thromboprophylaxis, baracitinib efficacy, long-term symptoms in adults, and sustained symptoms after severe disease. Hosts: Daniel Griffin and Vincent Racaniello   Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Overlooked shortcomings of observational studies (Op For Inf Dis) Guidelines for clinical management (Op For Inf Dis) ER visits and hospitalization among children (MMWR) Hospitalization of adolescents (MMWR) Seroprevalence in the US (JAMA) Seroprevalence in Kenya (JAMA) Infections after vaccine (medRxiv) Israel data dashboard Guidelines on anticoagulation for thromboprophylaxis (Blood Adv) Baricitinib efficacy (Lancet) Long term symptoms, US adults (MMWR) Severe disease associated with long term symptoms (medRxiv) Letters read on TWiV 803 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 802: Another epitope with Shane Crotty

    Play Episode Listen Later Sep 9, 2021 106:50

    Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls SARS-CoV-2 immune memory 8 months post-infection (Science) SARS-CoV-2 T cell epitopes (Cell Host Microbe) Letters read on TWiV 802 Timestamps by Jolene. Thanks! Weekly Picks Brianne – How the cat gets its stripes Kathy – Kurzgesagt on Giruses (giant viruses) and beautiful APOD Rich – The 1911 Triangle Factory Fire; Triangle: The Fire That Changed America by David Von Drehle Vincent – Two Top F.D.A. Vaccine Regulators Are Set to Depart During a Crucial Period Listener Picks Debby – River Runner Lin – Your Vaccinated Immune System Is Ready for Breakthroughs Intro music is by Ronald Je Send your virology questions and comments to twiv@microbe.tv

    TWiV 801: We can hear the coffin

    Play Episode Listen Later Sep 5, 2021 117:21

    The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade. Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls COVID-19 excess mortality (eLife) Tracking pandemic death toll (eLife) COVID-19 vaccines and delta variant (NEJM) Slave trade carries viruses into Mexico (eLife) Letters read on TWiV 801 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Victor Borge, Phonetic Punctuation Brianne – Cat TV Rich – Cochrane review: Ivermectin for preventing and treating COVID‐19 Alan – Cockpit video of flying into Oshkosh Vincent – Medical News Network Morning Medical Update Listener Pick Jody – Human Body Theatre and Plagues: The Microscopic Battlefield Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 800: COVID-19 clinical update #78 with Dr. Daniel Griffin

    Play Episode Listen Later Sep 4, 2021 52:30

    In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Do not take veterinary ivermectin (FDA) Ivermectin side effects (CDC) Do not use convalescent plasma (IDSA) COVID-19 in pregnant women (JAMA) Children and COVID-19 data (AAP) Long COVID in 11-17 year olds (Res Square) Delta outbreak elementary school (MMWR) Validation of at-home antigen test (JAMA) Shedding in infected vaccinated people (medRxiv) Compared antibody responses after mRNA vaccination (JAMA) AZD7442 PROVENT phase III (AZ) Fluvoxamine trial (medRxiv) One-year outcomes hospital survivors (Lancet) Post-vaccination illness (Lancet) Letters read on TWiV 800 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 799: A very model of a modern TWiV

    Play Episode Listen Later Sep 2, 2021 128:21

    TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Neutralizing antibodies predict protection against symptomatic COVID-19 (Nat Med) Host and vector importance for Ross River virus (eLife) Coronavirus in the U.S.: Latest Map and Case Count (NY Times) Letters read on TWiV 799 Timestamps by Jolene. Thanks! Weekly Picks Brianne – A microscopic video shows the coronavirus on the rampage Kathy – Sabin Oral Sundays in Cuyahoga County, 1962 Rich – The Continuing COVID-19 Pandemic: Current Issues and Glimpse Into the Future Vincent – Demand Surges for Deworming Drug for Covid, Despite Scant Evidence It Works Listener Picks Ronald – Immunity to COVID-19 could last longer than you'd think Agnes – Space Shuttle Prints Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 798: Rats, more coronaviruses!

    Play Episode Listen Later Aug 29, 2021 116:56

    The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China. Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Biden preliminary report on virus origins (NY Times) Window on SARS-CoV-2 origins closing (Nature) WHO Committee members on TWiV 760 Origins of SARS-CoV-2 review (Cell) Comirnaty? Really Pfizer? (FDA) Why the weird name for Pfizer vaccine (Quartz) US vaccine names (CDC) More coronaviruses from rodents in China (J Viral) Timestamps by Jolene. Thanks! Weekly Picks Dickson – The Brilliant Abyss by Helen Scales Kathy – Solar System ball drop Rich – Dr. Fox effect Alan – Patty Wagstaff virtual airshow cockpit video Vincent – Office Hours Listener Picks Karen – The Dog Will See You Now Alicia – Bio-Rad GTCA Song Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 797: COVID-19 clinical update #77 with Dr. Daniel Griffin

    Play Episode Listen Later Aug 28, 2021 40:45

    In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 false dichotomies (BMC Inf Dis) Virological characteristics of infections (medRxiv) Transmission among close contacts (JAMA) Comirnaty licensed (FDA) Cost of hospitalization of unvaccinated (Health Sys Tracker) 29 times higher hospitalization among unvaccinated (MMWR) Third dose boosts antibody potency and breadth (medRxiv) J&J second dose (J&J) Letters read on TWiV 797 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 796: The vary hungry spike with Paul and Theodora

    Play Episode Listen Later Aug 22, 2021 113:40

    Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Paul Bieniasz and Theodora Hatiziiouannou Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode High genetic barrier for SARS-CoV-2 antibody escape (bioRxiv) Enhanced antibody one year after COVID-19 (Nature) Letters read on TWiV 796 Timestamps by Jolene. Thanks! Weekly Picks Dickson – NIF and Photon Science: fusion reaction generates 1.3 MJ Brianne – The PCR Song Rich – 1) How Boston Dynamics' Spot Robot Works! 2) Inside the lab: How does Atlas work?3) Atlas | Partners in Parkour Theodora – Kevin Parry turning into random objects Vincent – Lex Fridman Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 795: COVID-19 clinical update #76 with Dr. Daniel Griffin

    Play Episode Listen Later Aug 21, 2021 36:52

    In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early convalescent serum in high-risk outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Age and pediatric household transmission (JAMA) Rapid antigen testing in remote communities (MMWR) Shedding of infectious virus from vaccinated individuals (medRxiv) Additional vaccine doses for immunocompromised (FDA) New vaccine mandate for New York (NYS) Vaccination suppresses variant emergence (medRxiv) mRNA vaccine effectiveness in nursing homes (MMWR) Effectiveness of mRNA vaccines against hospitalization (MMWR) mRNA vaccine sustained effectiveness against hospitalization (MMWR) No benefit of convalescent plasma for high-risk outpatients (NEJM) Letters read on TWiV 795 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 794: PAMS spray SARS-CoV-2

    Play Episode Listen Later Aug 15, 2021 117:53

    TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Halls (ASV) Arboviral illness, US, 2019 (MMWR) Estimating SARS-CoV-2 infectiousness (Science) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Climate Reports | United Nations Brianne – Astronomy Picture of the Day: A Perfect Spiral Rich – COVID-19 false dichotomies Alan – Fixing broken machines Vincent – MKBHD Studio Tour 2021 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 793: COVID-19 clinical update with Dr. Daniel Griffin

    Play Episode Listen Later Aug 14, 2021 41:26

    In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine effectiveness against transmission (Euro Surveill) Effectiveness of daily antigen tests (medRxiv) Interim guidance for fully vaccinated people (CDC) Elapsed time since BNT162b2 vaccine and reinfection (medRxiv) Reduced risk of infection after vaccination (MMWR) Therapeutic anticoagulants in critically ill patients (NEJM) 6 month outcomes in hospitalized patients (J Gen Int Med) Letters read on TWiV 793 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 792: Transmission with Jeffrey Shaman

    Play Episode Listen Later Aug 12, 2021 99:37

    Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Jeffrey Shaman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode A guide to R (Nature) Epidemiology of three SARS-CoV-2 VOC (medRxiv) Impact of delta variant in India (medRxiv) Letters read on TWiV 792 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Social Lives of Giraffes Kathy – Saturn's Iapetus, moon in 3-D Vincent – Arkansas Governor Wants To Reverse A Law That Forbids Schools To Require Masks Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 791: A mad virologists' T party

    Play Episode Listen Later Aug 8, 2021 123:47

    TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 in wild deer (bioRxiv) Rapid T cell induction by mRNA vaccine (Nature) T cell depleted macaques recover from SARS-CoV-2 infection (mBio) Letters read on TWiV 791 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Virgin Hyperloop shows off the future Brianne – BioNumbers Rich – Advice will evolve as COVID situation changes Alan – Mars Perseverance-themed geocaching swag Vincent – Mattel's Barbie Turns Women Of Science, Including COVID Vaccine Developer, Into Dolls Listener Picks Nancy – Vaccines at a Party Jeff – How to Survive a Plague, Part 2 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 790: COVID-19 clinical update #74 with Dr. Daniel Griffin

    Play Episode Listen Later Aug 7, 2021 49:27

    In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of infection and impact on quality of life 1-6 months after illness. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Outbreak in Barnstable County, MA (MMWR) Kinetics of delta variant infections (medRxiv) Prophlaxis with Regeneron mAbs (Regeneron) Subcutaneous mAbs to prevent COVID-19 (NEJM) Variant neutralization by infection or vaccine antibodies (Clin Inf Dis) Remdesivir associated with longer hospital stays (JAMA) Post-acute sequelae (Op For Inf Dis) Letters read on TWiV 790 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 789: Does delta mean a change?

    Play Episode Listen Later Aug 5, 2021 108:32

    TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NYC first to require vaccination proof (Reuters) Leaked internal CDC document (WaPo) Manuscripts on increased virulence (one, two, three) Disease protection by non-neutralizing antibodies (Cell) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Nobel Prize Games Kathy – Snail sensors Rich – In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope by Rana Awdish Vincent – The Provincetown Covid data is actually good news (if you are vaccinated) and I Was the Architect of Operation Warp Speed. I Have a Message for All Americans. Listener Pick Jake – NASA spinoff Peter – Bernard, the Extraordinary Moth Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 788: neuroCOVID with Kiran Thakur, MD

    Play Episode Listen Later Aug 1, 2021 121:44

    Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Kiran Thakur Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 neuropathology (Brain) Infections in vaccinated people (MMWR) Infections in vaccinated people (NEJM) Letters read on TWiV 788 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Simone Biles and Suni Lee Brianne – How Speed and Distance Dictate the Way Olympians Run Rich – CDC reversal on indoor masking prompts experts to ask, ‘Where's the data?' Vincent – Paul and the Mosquitos Listener Pick Lin – Your Vaccinated Immune System is Ready For Breakthroughs Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 787: COVID-19 clinical update #73 with Dr. Daniel Griffin

    Play Episode Listen Later Jul 31, 2021 46:09

    In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in vaccinated health care workers. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Updated mask guidance (CDC) Infections in public school district employees (MMWR) 10% of positive kids need hospitalization (Houston Chronicle) Effectiveness of vaccines vs delta variant (NEJM) Antibody response after third vaccine dose (JAMA) Severe COVID-19 in kidney transplant patients (Kidney Intl) mRNA vaccine protection with or without prior infection (medRxiv) Doxycycline ineffective (Lancet) Neurological manifestations (Lancet) Infections in vaccinated health care workers (NEJM) Letters read on TWiV 787 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 786: You make mucus and you move it

    Play Episode Listen Later Jul 29, 2021 103:31

    TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Off-season RSV in Australia (medRxiv) Impaired innate immunity in severe COVID-19 (Cell) Letters read on TWiV 786 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Science of Swimming Kathy – Talking to the vaccine hesitant  and covidactnow.org Rich – The Disinformation Dozen | Center for Countering Digital Hate (CCDH on wiki) Vincent – Russia discards Pirs docking port to clear way for new space station module (IG post) Listener Pick April – Pemberton Aviation (Facebook, YouTube) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 785: COVID-19 Q&A with Dr. Daniel Griffin

    Play Episode Listen Later Jul 28, 2021 59:13

    In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Letters read on TWiV 785 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 784: Virtually live from ASV

    Play Episode Listen Later Jul 25, 2021 79:47

    Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Brianne Barker Guests: Joseph Hyzer and Moriah Szpara Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Genome of HSV1 from multiple sites in one person (J Inf Dis) Rotavirus disrupts calcium homeostasis (mBio) Rotavirus protein activates calcium sensor (J Virol) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Inside of Mars is not like Earth Brianne – AlphaFold Rich – Tesla motors Alan – Diving for antique beer Vincent – Dolly Parton Tried. But Tennessee Is Squandering a Miracle Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv  

    TWiV 783: COVID-19 clinical update #72 with Dr. Daniel Griffin

    Play Episode Listen Later Jul 23, 2021 44:26

    In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Long COVID in children (JAMA) Outcomes after MIS-C (Pediatrics) Guidance for school opening (Amer Acad Ped) Infection in well traced delta outbreak (medRxiv) Immune memory 8 months post-infection (Science) Low dose mRNA vaccine enhances T cells (medRxiv) Protection after infection (Lancet) Assessment of BinaxNOW (Sci Rep) Rapid POC antigen tests (Cochrane Rev) Oral azithromycin ineffective (JAMA) Post discharge symptoms in Nigeria (AJTMH) Therapeutics for low and middle income countries (AJTMH) Letters read on TWiV 783 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 782: An antibody for all sarbecoviruses

    Play Episode Listen Later Jul 22, 2021 62:53

    On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Immune responses after heterologous COVID-19 vaccine boost (Nat Med) Undiagnosed SARS-CoV-2 infections in US (Sci Transl Med) Broadly neutralizing sarbecovirus antibody (Nature) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 781: My genome is left to tell the tale

    Play Episode Listen Later Jul 18, 2021 106:40

    The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 on dogs and cats (Viruses) Maternal to neonatal transfer of SARS-CoV-2 antibodies (J Clin Investîmes) Retroviral evolution in cetaceans and their ancestors (Plos Path( Letters read on TWiV 781 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Current Map | U.S. Drought Monitor Brianne – A comic strip about immune responses Alan – Superliminal game Vincent – Birds are dying in NJ Listener Picks 2listening1 – Renewal Em – Cognitive Surplus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 780: COVID-19 clinical update #71 with Dr. Daniel Griffin

    Play Episode Listen Later Jul 17, 2021 41:22

    In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode School and child care guidance (CDC) Transmission in schools (CDC) Accuracy of lateral flow diagnostics (Lancet) GBS with Ad.26.CoV2.s vaccine (FDA) Ad.26.CoV2.s interim immunogenicity (NEJM) mRNA vaccine effectiveness to prevent hospitalization (medRxiv) Bamlanivimab plus Etesevimab (NEJM) Meta-analysis of ivermectin studies (Clin Inf Dis) Letters read on TWiV 780 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 779: Evolving boosterism

    Play Episode Listen Later Jul 11, 2021 99:57

    TWiV reviews evidence that mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode mRNA vaccine boosts cross-variant neutralizing Ab (Science) mRNA vaccine boosts variant B and T cell responses (Science) Directed evolution of virus-like nucleocapsid (Science) Letters read on TWiV 779 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Science of Chocolate Chip Cookies Alan – Keeping Black students in STEM Vincent – Antiviral Program for Pandemics Listener Pick Mark – Curator on the Loose, Classic Airliners and Vintage Pop Culture, Flying Men, Flying Machines, Thai Flying Club Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 778: COVID-19 clinical update #70 with Dr. Daniel Griffin

    Play Episode Listen Later Jul 10, 2021 37:06

    In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induce serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Efficacy of portable air cleaners (MMWR) Ad26.COV2.S elicited neutralization of variants (bioRxiv) Prevention of COVID-19 with mRNA vaccines (NEJM) Ivermectin to prevent hospitalization (BMC Inf Dis) IL-6 antagonists and mortality (JAMA) Impact of vaccination on long COVID (Lancet) Letters read on TWiV 778 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 777: SARS-CoV-2 fitness with Ron Fouchier

    Play Episode Listen Later Jul 8, 2021 96:23

    Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Ron Fouchier Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ron Fouchier on TWiV 177, 291, 557 Mutations driving H5N1 airborne transmission in ferrets (Cell) SARS-CoV and SARS-CoV-2 transmission among ferrets (Nat Comm) Avian influenza virus transmission among seals (Cell Host Micr) Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Science News Cycle Kathy – mRNA Day Kariko & Weissman lectures and Q&A Vincent – Just Planes Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 776: Yes! We have no pangolins

    Play Episode Listen Later Jul 4, 2021 108:39

    TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Animal sales from Wuhan markets before COVID-19 (Sci Rep) Dengue control by Wolbachia-infected mosquitoes (NEJM) Fatal dengue in Florida (NEJM) Letters read on TWiV 776 Timestamps by Jolene. Thanks! Weekly Picks Brianne – You Know You've Worked Too Long in a Lab When… Alan – Massachusetts vaccine lottery Vincent – Coonhound paralysis Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 775: COVID-19 clinical update #69 with Dr. Daniel Griffin

    Play Episode Listen Later Jul 3, 2021 44:12

    In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Worry about human behavior, not variants (NY Times) Moderna and Pfizer vaccines vs delta variant Depression among public health workers (MMWR) Correlates of protection (medRxiv) mRNA vaccine in AZ recipients (Lancet) Prior infection rescues B and T cell responses to variants (Science) Effect of vaccination on household transmission (NEJM) mRNA vaccines induce germinal responses (Nature) Novavax vaccine phase 3 results (NEJM) EUA for tocilizumab (FDA) Long COVID, next national health disaster (NEJM) Letters read on TWiV 775 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences

    Play Episode Listen Later Jul 1, 2021 104:14

    Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guests: Kristian Andersen and Robert Garry Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Andersen laboratory Recovery of deleted deep sequencing data (bioRxiv) Animal sales from Wuhan wet markets (Sci Rep) Danielle Anderson on Wuhan Lab (Bloomberg) Timestamps by Jolene. Thanks! Weekly Picks Kathy – STEVE over Copper Harbor, MI Vincent – Human Behavior During the Pandemic Is More Important Than Any Covid Variant Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

    TWiV 773: Laurie Garrett, pandemic prophet

    Play Episode Listen Later Jun 27, 2021 113:26


    Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Laurie Garrett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Lauriegarrett.com The Coming Plague Betrayal of Trust Trump sabotaged coronavirus response (Foreign Policy) ASV Vaccine Town Hall Timestamps by Jolene. Thanks! Weekly Picks Brianne – A Pivotal Mosquito Experiment Could Not Have Gone Better Kathy – Microbiology at the Movies Vincent – When a Good Scientist Is the Wrong Source Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv


    TWiV 772: COVID-19 clinical update #68 with Dr. Daniel Griffin

    Play Episode Listen Later Jun 26, 2021 38:03

    In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 and birthday parties (JAMA) Vaccines in transplant patients (Ann Int Med) Reinfection of recovered patients (Clin Inf Dis) Azithromycin lack of efficacy (Rev Med Virol) Bacterial and fungal infections in hospitalized patients (Op For Inf Dis) mAb treatment of ambulatory patients (Op For Inf Dis) Remdesivir reduction of mortality (Gilead) Letters read on TWiV 772 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

    TWiV 771: Borna hundred million years ago

    Play Episode Listen Later Jun 20, 2021 108:05

    A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2. Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 100 million year old bornavirus infections (PNAS) Bornaviruses across geological timescales (PNAS) Bornaviruses previously on TWiV 303, 347, 548 Novel bat SARS-CoV-2 related coronaviruses (Cell) Letters read on TWiV 771 Timestamps by Jolene. Thanks! Weekly Picks Amy – A relic from the Jurassic era Alan – World of Wonders, by Aimee Nezhukumatathil Vincent – Tom Buck's YouTube Channel Listener Pick Victor – Vaccines: A measured response Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

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