SrinathPharmcast

ANTI CONVULSANTS DRUGS (part 1) : 1. GABAPENTIN & PREGABALIN. 2. BARBITURATES (phenobarbital & primidone ). 3 . BENZODIAZEPINES ( CL+ AM) - clobazam , clonazepam, clorazepate ... “AM” - diazepam, midazolam , lorazepam : USED TO TREAT STATUS EPILEPSY 4. ETHOSUXIMIDE : treat ABSCENCE SEIZURE 5 . PHENYTOIN & FOSPHENYTOIN , purple glove syndrome . 6 . LAMOTRIGINE 7 . Lennox gastaut syndrome : RUFINAMIDE , VALPROATES , BENZODIAZEPINES, TOPIRAMATE

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WARFARIN. Introduction , mechanism of action , Side Effects :- BLEEDING , RETROPERITONEAL HEMORRHAGE ,PURPLE TOE SYNDROME , OSETEOPOROSIS RELATED BONE FRACTURE .. CLINICAL CONSIDERATIONS:- FIRST TRIMESTER - FETAL WARFARIN STNDROME - Nasal hypoplasia , narrowed Nasal bridge , other limbic and cardio abornmalities , SECOND & THIRD TRIMESTER : CNS abornmalities , ocular defects , seizures , low birth weight. ... ANTIDOTE : PHYTOMENADIONE (VIT k) CYP P450 INHIBITORS: macrolides, Flucanazole , Protease inhibitors. CYP 450 INDUCERS : Phenytoin , Carbamazepine, Rifampin .. insta id : Srinath Kalepu .. LINKEDIN : Kalepu Srinath

BLACK BOX WARNINGS ⚠️ : 1. Pioglitazone & rosiglitazone Worsen CHF & fluid retention . 2. METHADONE : respiratory depression

Discussed drugs : 1. DOC for ATROPINE TOXICITY 2. DOC for BENZODIAZEPAM TOXICITY , “ Z DRUGS - ZOLPIDEM , ZOPICLONE , ESZOPICLONE 3. AMINOGLYCOSIDES 4. ERYTHROMYCIN - MOTILIN AGENT (gastro pro kinetic agent) 5 . Trimethoprim & sulfamethoxazole - treat PNEUMOCYSTIS PNEUMONIA caused by PNEUMONOCYSTIS JIROVECI

Discussed on 5 drugs : 1. Difference between reversibile anti cholinesterase inhibitors and irreversible anti cholinesterase inhibitors ; ANTIDOTE : pralidoxine (2 PAM - 2 purified Aldoxime methyl chloride ) , 2. METHACHOLINE : bronchial hyperactivity , more potent for M2 receptor , but in this test we used because of M3 , 3. OPIOD SIDE EFFECT : Constipation 4. BRADYCARDIA (DOC) : ATROPINE 0.5 to 1 mg 5. METFORMIN: malabsorption of B12

1. Paracetamol overdose : depletion glutathione ,NAPQI ; n acetyl p bennzquinone Imine. 2. ASPIRIN : it causes Rye syndrome (6 months to 18 year old ), risk of bleeding . 3. SILDENAFIL CITRATE : inhibits PDE 5 (phosphodieaterase type 5 ) . 4. SENNA : weaker laxative than biscodyl and castor oil 5. PENCILLAMINE : chelating agent to treat WILSONS DISEASE , CYSTINURIA .

Drugs discussed in this topic : AMOXICILLIN, LAMOTRIGINE , OLANZAPINE , LITHIUM TOXICITY, CLAVULANIC ACID