Podcasts about Metformin

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-445 Overview: Managing knee osteoarthritis (OA) in patients with obesity can be challenging, especially when standard treatments fall short. In this episode, we discuss emerging evidence on the use of metformin to reduce knee pain in patients without diabetes and explore how this option could expand your approach to OA management. Episode resource links: Pan F, Wang Y, Lim YZ, et al. Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: A Randomized Clinical Trial. JAMA. 2025;333(20):1804-1812.  Guest: Alan M. Ehrlich, MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com   

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-445 Overview: Managing knee osteoarthritis (OA) in patients with obesity can be challenging, especially when standard treatments fall short. In this episode, we discuss emerging evidence on the use of metformin to reduce knee pain in patients without diabetes and explore how this option could expand your approach to OA management. Episode resource links: Pan F, Wang Y, Lim YZ, et al. Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: A Randomized Clinical Trial. JAMA. 2025;333(20):1804-1812.  Guest: Alan M. Ehrlich, MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com   

In this episode, we explore groundbreaking research on managing antipsychotic-induced weight gain through a comprehensive network meta-analysis. Could the combination of low-dose metformin and lifestyle modifications be the game-changer that helps patients maintain both mental stability and physical health? Faculty: Scott Beach, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.75 CME: Quick Take Vol. 71 Antipsychotic-Induced Weight Gain: Best Management Strategies

Dr. Robert Baron outlines major updates in type 2 diabetes care, emphasizing that blood sugar control alone does not significantly reduce cardiovascular risk, though it helps prevent microvascular complications. New guidelines now prioritize medications with proven cardiovascular and kidney benefits—GLP-1 receptor agonists and SGLT2 inhibitors—over traditional first-line therapy like metformin. Baron explains how these newer drugs not only lower blood sugar but also reduce the risk of heart attack, stroke, kidney disease, and heart failure, with added benefits such as weight loss. He also covers changes in screening, diagnosis, blood pressure goals, and individualized treatment strategies based on age, comorbidities, and patient preferences. [Health and Medicine] [Show ID: 40756]

Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Today we're switching gears a bit to talk about a medication rather than a peptide — metformin. If you're someone who's interested in peptides for metabolic health or inflammation, you've probably heard metformin mentioned alongside them. It's been around for decades as a diabetes medication, but recently it's gaining attention for its potential benefits beyond blood sugar, including longevity, inflammation, and neuroprotection — even in people who don't have diabetes. Let's get into it. Metformin and Longevity Can metformin really help us live longer? One of the biggest sparks came from a 2014 study published in Diabetes, Obesity and Metabolism, where researchers found that diabetics on metformin actually lived longer than non-diabetics not taking the medication.  The authors suggested that metformin may offer protective benefits beyond glucose control, possibly by reducing oxidative stress and slowing cellular aging. This inspired the launch of the TAME trial—short for Targeting Aging with Metformin—which is designed to test whether metformin can delay the onset of age-related diseases like cancer, cardiovascular disease, and cognitive decline. While results are still pending, it's the first large-scale effort to study aging as a treatable condition, not just a process. Inflammation and Immunometabolism Next up: inflammation. Chronic low-grade inflammation is at the root of so many health issues—heart disease, dementia, even depression. Metformin appears to blunt systemic inflammation by activating AMPK. Think of AMPK as a metabolic master switch that lowers inflammatory signaling. A 2021 review published in Pharmacological Research found that metformin can inhibit NF-κB, a major pathway that drives inflammation. It also helped lower levels of CRP—a protein made by the liver that rises when there's inflammation from things like infection, injury, or chronic disease—and IL-6, another immune system protein commonly elevated in chronic inflammatory conditions. Because of these anti-inflammatory effects, researchers have been exploring metformin's potential in conditions beyond diabetes, including autoimmune diseases, multiple sclerosis (MS), PCOS, and even COVID—where it's been linked to lower mortality in patients with diabetes. Brain Health and Neuroprotection What about the brain? Can metformin help protect against cognitive decline? There's some promising data here too. A 2017 study in Aging Cell found that metformin improved neurogenesis in the hippocampus of aged mice—basically, helping old brains grow new neurons. In 2019 a cohort study in JAMA Network reported that people with type 2 diabetes taking metformin had a lower risk of developing dementia compared to those not taking it. Mechanisms may include reduced insulin resistance in the brain, less oxidative stress, and—again—AMPK activation, which promotes mitochondrial health and energy production. Still, human trials are mixed, and more controlled research is needed before we can call it a “smart drug.” Lower Cancer Risk So, here's an interesting one—can metformin actually lower the risk of cancer? Well, the short answer is: maybe. People with diabetes tend to have a higher risk of developing certain types of cancer, so part of metformin's benefit could just come from better managing blood sugar and insulin levels. But what's really exciting is that researchers think metformin might do even more than that. There's evidence suggesting it could have direct effects on cancer cells—like slowing down their growth or making the environment less friendly for tumors. Some studies have found lower rates of cancers like breast, colon, and prostate in people taking metformin. Now, this isn't a magic bullet or anything, but it's a promising area of research that's getting a lot of attention. So metformin might be pulling double duty: managing diabetes and potentially helping reduce cancer risk through other mechanisms we're still learning about. Metabolic Health for Non-Diabetics Now here's where it gets controversial—should healthy people without diabetes be taking metformin? Some researchers argue yes, especially for people with metabolic syndrome, prediabetes, or high inflammation. Metformin improves insulin sensitivity, reduces liver glucose production, and may even support modest weight loss. That said, there are tradeoffs. Metformin can cause stomach-related side effects (e.g., nausea, gas, heartburn, and diarrhea) and vitamin B12 deficiency (which may lead to nerve damage). It can also cause extreme fatigue.  Metformin may sometimes cause sexual side effects, like erectile dysfunction in men. Some studies suggest it might lower testosterone, which we know is important for male sexual health. But interestingly, other research points to metformin actually improving blood flow to the penis, which could help with erectile issues. So, it's a bit of a mixed picture—and it really depends on the individual. And although rare, it can cause lactic acidosis (a life threatening condition where lactic acid builds up in the blood) in older adults, people with advanced kidney disease, or those who drink excessive amounts of alcohol. So it's not a free pass.  So what are my final thoughts and who should you take metformin for longevity? Metformin isn't a one-size-fits-all solution, and it's definitely not something to start just because you heard about it on a podcast. We still need more research—especially in people without diabetes—to really understand who benefits most. But it might make sense for some people, like those with prediabetes, PCOS, metabolic syndrome, or even older adults looking to support healthy aging.  As always, it's something to talk through with your healthcare provider.  The science is exciting, but it's all about finding what makes sense for you. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Until next time, be well, and as always, have a happy, healthy week.

In first-ever study, keto diet scores vs. Parkinson's; Walk away from dementia; Loneliness can kill, but negative social ties can hasten biological aging; Researchers isolate potent memory compound from sage, rosemary; Sketchy knockoff weight loss drugs are flooding the marketplace; The popular vitamin you shouldn't take for sarcoidosis; When osteoporosis is so severe that even minor trauma causes rib fractures.

Water filters are surrounded by plastic. Won't we be exposed to microplastics by filtering our water?I'm 80 with borderline osteoporosis. Is working out with light weights okay for me?I have latent autoimmune diabetes. Is taking metformin appropriate until I have a need to start insulin?I'm taking warfarin. Can I safely take a hair growth supplement for women?

Kate, Mark, Gary and Henry discuss 4 important new studies relevant to primary care clinicians: negative pressure wound therapy for wounds healing by secondary intention, comparative effectiveness of acute migraine treatments, contrast enhanced mammography, US, or MRI for women with dense breasts, and metformin for knee pain in patients without diabetes.Negative pressure wound therapy: https://pubmed.ncbi.nlm.nih.gov/40250455/ Acute migraine treatments: https://pubmed.ncbi.nlm.nih.gov/40096693/ Best enhanced screening for women with dense breasts:  https://pubmed.ncbi.nlm.nih.gov/40412427/ Metformin for knee pain in patients without DM: https://pubmed.ncbi.nlm.nih.gov/40274279/

In a deeply enlightening podcast episode, Jay Campbell delves into the complex yet fascinating world of biohacking and longevity. Jay Campbell, a renowned physique champion, five-time bestselling author, and co-founder of Bio Longevity Labs, shares his vast knowledge and experience on hormone optimisation, peptide therapy, and cutting-edge wellness technologies that can transform health and extend life. What You'll Learn: Exploring Peptides and Hormones: Learn what peptides are, how they function in the body, and the importance of optimising hormones first for effective biohacking. Therapeutic Testosterone: Discover why Jay believes testosterone replacement is transformative and why more men are experiencing low testosterone levels. Peptide Legalities: Understand the differing legal statuses of peptides across countries, particularly in the U.S. and Australia. Mitochondria and Health: Delve into why red-light therapy and oxygen perfusion can significantly improve your mitochondrial health and overall vitality. Key Takeaways: Optimise Before Supplementing: Campbell emphasises the importance of addressing hormone deficiencies through comprehensive lab work before introducing therapies like peptide use. The Power of Testosterone: A potent tool in the arsenal of longevity, therapeutic testosterone is Campbell's foremost recommendation for overall health improvement. Peptide Insights: Discover the complexities and potential benefits surrounding peptide use, alongside understanding legal and practical implications. Mitochondrial Significance: Red light therapy and cutting-edge oxygen perfusion technologies present promising advancements in health optimization. Resources: Explore Bio Longevity Labs for the latest in peptide technology and applications. Stay informed about therapeutic advancements and practices through Jay Campbell's expertly authored books available at jay campbell Discover more about longevity and biohacking techniques through ongoing studies and expert discussions. Connect with Jay Campbell: Website: Jay Campbell Social Media: LinkedIn Face Book YouTube X Instagram Support the Podcast: If you found this episode valuable, consider subscribing and leaving a review on your preferred podcast platform. Sharing this episode could make a positive impact on someone exploring health optimisation strategies. Join the conversation about long-term health and longevity; these insights from Jay Campbell could transform your understanding of wellness and extend your lifespan with actionable knowledge and cutting-edge innovations. 02:48 Introduction to Jay Campbell's Career 03:25 Early Adoption of Peptides and Hormones 05:05 Legal Status and Misconceptions of Peptides 06:01 Founding Bio Longevity Labs 15:04 Understanding Peptides and Their Delivery Methods 20:12 Longevity and Regenerative Medicine 37:20 Understanding Body Fat Percentages for Longevity 37:45 Optimizing Endocrine System with Hormones and Peptides 39:29 The Benefits and Misconceptions of Metformin 42:35 Metformin's Impact on Exercise and Performance 48:31 Mitochondrial Optimization and Red Light Therapy 54:03 Advanced Biohacking Techniques: Oxygen and Ozone Therapy 59:32 Comprehensive Biohacking Stack for LongevitySee omnystudio.com/listener for privacy information.

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Join Renske & Olivier as they talk with Prof. Flavia Ciccutini about repurposing metformin for patients with overweight or obesity.

On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Karl Pfleger, aging biotechnology investor and creator of AgingBiotech.info, to dissect the rapidly evolving field of aging therapeutics. Karl breaks down the sector into two main categories: interventions that slow aging rates versus rejuvenation strategies that repair accumulated damage.Karl highlights the most promising areas in his investment portfolio, including senolytics for clearing senescent cells and epigenetic reprogramming technologies. He explains why current aging clocks aren't ready for clinical use and discusses the limitations of popular interventions like GLP-1 drugs and fasting protocols. The conversation reveals that 14 Phase 3 clinical trials are currently testing core aging therapeutics.The discussion covers recent FDA approvals for ATTR treatments and stem cell therapies, signaling the field's maturation. Karl emphasizes that meaningful life extension requires a "divide and conquer" strategy, targeting multiple aging mechanisms simultaneously rather than relying on single interventions. Despite exciting therapeutic developments, he maintains that optimizing diet, exercise, and sleep remains the most impactful strategy for extending healthspan today.Guest-at-a-Glance

Plus Reseach Chem Industry Update, SS-31 Experiment, Adding a compound to test, Metformin vs Berberine DNS 274 Dave Crosland & Scott McNally 0:00 intro 2:00 Studies of Deca on Heart Health 6:00 SS-31 9:40 Research Chem Industry Update 11:20 How much can I gain in 1 cycle? 23:00 Listener Questions 24:30 Adding a compound to test 25:25 Stress and weight gain 30:50 ED issues with high test 33:00 Primobolan scripts in UK 37:45 Finasteride with Anavar 38:00 Metformin vs Berberine 43:10 Too good of muscle gains? 51:45 How long can you run NPP? 55:0 Test EQ NPP - when to add compounds 59:30 Winstrol Timing 1:01:20 Skin Tags and AAS 1:0510 Ramping cycle dosing with time 1:08:30 Uncle Dave's Wisdom ✅ ✅ Modern Aminos New Peptide and Research Chem Affiliate : https://tinyurl.com/y4nts94n ✅ ✅Code THINKBIG ✅ Parabolic Peptides Great Research Tabs and Peps https://tinyurl.com/ycpnbjzd ✅ ✅Code THINK ✅ ✅SomaChems https://somachems.com ✅ ✅Code THINK

In today's episode, we're digging into a topic that impacts millions of women, but still isn't widely understood: Polycystic Ovary Syndrome or PCOS. It's a personal one for me, as I've had PCOS for over a decade now, and whenever I search for information about the condition, I'm faced with reddit threads rather than professional advice, because so little research is done into PCOS and conditions like it. So, I wanted to create a resource for people like me, who are struggling to understand what they're going through and desperate for information. So today we're talking symptoms, diagnosis, lifestyle changes that actually help, and how to advocate for yourself when you're not being heard. So, If you've ever struggled with your cycle, your skin, your mood, or been gaslit at the GP about your pain, this episode is for you.+DR HAZEL WALLACE Her new book, Not Just A Period: https://www.waterstones.com/book/not-just-a-period/hazel-wallace/9781035049592Instagram: https://www.instagram.com/drhazelwallace/?hl=en-gbWebsite: https://www.drhazelwallace.co.uk/ +CHAPTERS0:00 Introduction 02:06 Working Hard or Hardly Working 02:45 Hazel's PCOS journey 05:12 The difficulty of getting a diagnosis 8:13 What is PCOS and why is it so misunderstood?11:42 PCOS diagnosis requirements 14:39 PCOS vs Endometriosis16:00 Can you reverse PCOS? 16:55 Weight loss & PCOS 19:30 Nutrition tips for PCOS 23:46 Grace's PCOS journey this year27:59 Fasted exercise & women's health30:26 PCOS supplements33:00 Exercise & PCOS 40:57 The impact of stress 44:39 Insulin resitance 46:42 Metformin & spironolactone52:36 Medication vs Lifestyle56:00 Listener questions 58:11 Regular cycles & hormones 1:00:15 How to advocate for yourself at Drs1:01:47 Reducing PMS symptoms 1:05:10 Her biggest lesson 1:05:50 Best piece of advice +MY LINKS: https://gracebeverley.komi.io/+RETROGRADE, SHREDDY, TALA and THE PRODUCTIVITY METHOD are my own businesses, therefore any mention of them - whilst not being a sponsorship - is obviously monetarily endorsed. As usual, sponsorships do not change my opinions nor my honesty, but I will always disclaim to make sure motives are clear

In this episode of Resilience Unraveled, Dr Russell Thackeray chats to Dr. Julian Gershon Jr., a specialist in family medicine, sports medicine, and anti-aging and regenerative medicine, who shares insights from his 45-year career. He discusses his work with stem cell therapy, hormone balancing, and longevity science. The conversation highlights the significance of DNA methylation, telomere length, and how lifestyle choices impact aging. Dr. Gershon covers the benefits of GLP-1, Metformin, and the revolutionary potential of stem cell research. He also introduces his book, 'Beyond the Fountain of Youth,' and emphasizes the importance of self-awareness and proactive health management.00:00 Introduction and Guest Welcome00:38 Dr. Julian Gershon's Background and Expertise01:26 Understanding Longevity and Anti-Aging Medicine03:43 The Role of Telomeres in Aging06:10 The Importance of Diet and Lifestyle12:08 Hormone Balancing and Its Benefits21:36 Stem Cell Research and Its Potential23:02 About the Book: Beyond the Fountain of Youth24:48 Conclusion and Final ThoughtsYou can contact us at info@qedod.comResources can be found online or link to our website https://resilienceunravelled.com

The FiltrateJoel Topf Bluesky: @kidneyboy.bsky.social‬Jordy Cohen Bluesky: @jordybc.bsky.social‬Swapnil Hiremath Bluesky: @hswapnil.medsky.social‬Special Guest Edouard “call me Ed” Fu Assistant Professor and Medical Student, and second author of his second paper covered on NephJC. LinkedIn | Leiden University Medical CenterEditing bySimon Topf and Sophia AmbrusoThe Kidney Connection written and performed by by Tim YauShow NotesEd's first paper on NephJC: Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease: nationwide cohort study (NephJC | BMJ)Phenformin Wikipedia | Boca Raton NewsThe metformin black box (as part of the FDA Label)WARNING: LACTIC ACIDOSISPostmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metforminassociated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Metforminassociated lactic acidosis was characterized by elevated blood lactate levels (>5 mmol/Liter), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ratio; and metformin plasma levels generally >5 mcg/mL (see PRECAUTIONS).Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g. carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, and hepatic impairment.Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided (see DOSAGE AND ADMINISTRATION, CONTRAINDICATIONS, and PRECAUTIONS).If metformin-associated lactic acidosis is suspected, immediately discontinue metformin and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended (see PRECAUTIONS).Target Trial Emulation A Framework for Causal Inference From Observational Data. Miguel A. Hernán, MD, DrPH; Wei Wang, PhD; David E. Leaf, MD JAMA 2022Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study (NephJC | PubMed)Toxicokinetics of Metformin During Hemodialysis (KI Reports)Metformin in People With Diabetes and Advanced CKD: Should We Dare? Editorial that ran in AJKD along side the Lambourg manuscript (AJKD)Immortal Time Bias in Cohort Studies of Kidney Transplant Recipients (Kim SJ Amer J Trans 2010)Ed's Target trial review in JASN which Jordy mentioned and includes an explanation of the obesity paradox by depletion of the susceptibles. (Fu JASN 2023)Ed's Grand Rounds at Ottawa on YouTube. Very good.Response by Cohen et al to Letter Regarding Article, “Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19” by Jordy and the crew Circ Res 2000Review article on the issue: Evaluating sources of bias in observational studies of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker use during COVID-19: beyond confounding Jordy and a different crew J Hyperten 2021Figure S5: Weighted cumulative incidence curves for MACE, by treatment strategyThe S4 image that Swap lovedTubular SecretionsJordy Andor Season 2 on Disney+ (Wikipedia)Swapnil Murderbot on Apple TV+ (Wikipedia)Eduoard: New house and grant Grant Grant (Wikipedia)Joel Topf Three Body Problem Audio book (Audible)

Metformin is one of the world's most prescribed drugs for type 2 diabetes - but could it also help with knee osteoarthritis? In this episode of Joint Action, Prof. David Hunter is joined by Prof. Flavia Cicuttini to unpack the results of a groundbreaking clinical trial that tested metformin as a new treatment for knee pain in people with knee osteoarthritis. Tune in to hear what the study found, how the drug works, who might benefit, and what this could mean for delaying joint replacement. RESOURCES Article: Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: https://jamanetwork.com/journals/jama/article-abstract/2833338 CONNECT WITH USTwitter: @ProfDavidHunter @jointactionorgInstagram: @osteoarthritisresearchgroupEmail: osteoarthritis.research@sydney.edu.auWebsite: https://www.jointaction.info/podcast Hosted on Acast. See acast.com/privacy for more information.

Our latest podcast episode unpacks the 2025 JAMA Review on Type 2 Diabetes

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Join us for a deep dive into the IVF patient journey with special guest Kelly Gonda, a passionate pharmacist and Fertility Nurse Practitioner. In this episode, we explore how pharmacists can improve safety, outcomes, and access to fertility treatment by understanding the science of in vitro fertilization and the medications involved.

This episode is brought to you by Caldera Lab, State & Liberty, and Joi & Blokes. We are joined today by functional health coach Vince Pitstick. He delves into the intricate relationship between success and well-being, exploring the interplay of psychology, genetics, and nutrition. The episode covers a wide array of topics, from the effects of the "warrior gene" on dopamine metabolism and the challenges of anhedonia in high achievers, to the benefits of a diverse and seasonally adjusted diet. Vince also shares his personal journey overcoming OCD and addiction, illustrating the power of functional medicine and holistic approaches in achieving sustainable success and mental wellness. This episode is your comprehensive guide to unlocking your full potential by harmonizing physical, mental, and spiritual growth. Follow Vince @vince_pitstick Follow Chase @chase_chewning ----- In this episode we discuss... (00:00) Psychology and Physiology of Success (11:59) Link Between Biology, Genes, and Personalized Success (17:35) Build Your Best Diet and Nutrition Diversity (27:29) Why You Need Diet Variation (39:09) Optimizing Health With Lab Analysis (54:49) Integrating Functional Medicine (01:05:04) Balancing Fitness, Health and Success (01:12:10) Building a Foundation Before Optimizing (01:23:52) Benefits of Peptides in Biomedicine (01:32:10) Peptides cont'd, Cancer Risk, and GLP-1 (01:38:51) Metformin and Adaptation in Health (01:46:48) The Metabolic Impact of Chronic Dieting (01:54:57) Ever Forward ----- Episode resources: Save 20% on any men's skincare item with code EVERFORWARD at https://www.CalderaLab.com Save 15% on performance menswear that fits athletic build guys with code EVERFORWARD at https://www.StateAndLiberty.com  Save 10% on any labs with code CHASE at https://www.JoiAndBlokes.com  Watch and subscribe on YouTube Learn more about Vince at VidalCoaching.com

Severe nausea and vomiting in pregnancy/hyperemesis gravidarum (HG) takes a toll on patient, and the healthcare system. According to a June 2024 ACOG Clinical Expert Series on the subject, GFD15 and IGFBP7 both play important roles in placentation, appetite, and cachexia that are linked to hyperemesis gravidarum. Specifically, LOW pre-pregnancy GFD15 is associated with increased frequency of HG as GFD15 levels spike post pregnancy in an otherwise "naive" system. Since metformin increases GFD15, can this be a pre-pregnancy, chemoprophylactic option in high risk women? New data just released (June 2025; AJOG) provides some eye-opening insights. Listen in for details.

What if your body had built-in tools to regenerate itself but you've been looking in the wrong places? Dr. Khoshal Latifzai reveals overlooked therapies like peptides, shockwave, stem cells, & ketamine that go beyond symptom masking. He explains how athletes & longevity seekers use diagnostics, fasting, & advanced biologics to stay ahead of aging & feel better, faster. Meet our guest Dr. Khoshal Latifzai is a Yale-trained, board-certified emergency physician who founded Rocky Mountain Regenerative Medicine to focus on prevention, longevity & performance. Inspired by his humanitarian work & experience in critical care, he blends advanced biologics, hormone optimization & regenerative therapies to treat pain, enhance vitality & extend healthspan. His personalized approach serves athletes, executives & anyone seeking to thrive at every stage of life. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Track biomarkers regularly through frequent, detailed bloodwork to personalize health strategies & catch negative effects early Cycle medications & supplements like peptides & metformin to prevent tolerance & maintain effectiveness Personalize metformin use since benefits, dosing & side effects vary Use low-dose rapamycin for potential longevity benefits, monitoring closely with regular biomarker testing Go beyond standard panels by checking ApoB, Lp(a) & homocysteine for better insight into cardiovascular risk Question outlier biomarkers like A1C by considering factors such as red blood cell lifespan before making assumptions Use ketamine therapy under supervision to address depression & anxiety when conventional treatments fall short Trigger targeted repair in joints or tissues using shockwave therapy to activate local stem cell healing Bank stem cells early while they're younger & more effective to improve outcomes for future injuries or illnesses Support stem cell health with regular fasting, exercise & optimized metabolic function to maintain potency with age Episode Highlights 09:39 Metformin & Rapamycin for Longevity 16:53 Underrated Biomarkers & Diagnostics 24:23 Ketamine Therapy for Brain Remodelling 45:30 Shockwave & Stem Cell Therapy Deep Dive   Links Watch it on YouTube: https://youtu.be/UbA4DzzNqN0  Full episode show notes: outliyr.com/214 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

In this podcast episode of Integrative Cancer Solutions Dr. Karlfeldt interviews Dr. Chris Apfel about his integrative approaches to cancer treatment. Dr. Apfel shares his journey from traditional medicine to integrative oncology, sparked by his father's lung cancer diagnosis. This personal experience led him to question conventional cancer treatments after learning about their low success rates, particularly for stage four lung cancer. Dr. Apfel discusses his development of the Onca test, which can identify effective cancer therapies within a week by culturing tumor fragments. This test evaluates a wide range of treatments including chemotherapies, targeted therapies, and repurposed drugs. He emphasizes the importance of avoiding ineffective treatments that can harm the immune system and diminish quality of life, while highlighting the potential of repurposed drugs like statins, Metformin, and Itraconazole. The conversation addresses tumor heterogeneity and the need for representative biopsy samples, particularly from metastatic sites. Dr. Apfel explains that the Onca test is commercially available, with discounts offered to patients willing to share their data for research purposes. He discusses various methods for obtaining tumor samples and the importance of timing in the collection process.Dr. Apfel emphasizes patient advocacy and the need for patients to be informed about their treatment options. He notes that the Onca test can double the odds of a positive tumor response and significantly increase median survival rates. The podcast concludes with Dr. Apfel expressing interest in collaborating with Dr. Folt's center to help more cancer patients through this innovative approach to personalized cancer treatment.About Dr Chris Apfel:Chris Apfel, MD, PhD, MBA is a physician and clinical researcher with over 100 published papers, including a six-factor clinical prediction model published in NEJM that led to the development of The Apfel Score, a clinical calculator used universally to predict the risk of postoperative nausea and vomiting, and Dr Apfel's ultimate recruitment to the US and the University of California, San Francisco.Dr. Apfel was driven to revolutionize the field of cancer patient treatment after losing his mother to a long battle with ovarian cancer and his father to lung cancer. Witnessing their suffering inspired him leave the clinical department at UCSF to develop more efficient ways to identify the best treatment plans for cancer patients.Dr Apfel received his MD and PhD from the University of Giessen in Germany and his MBA from Wharton at the University of Pennsylvania. He is the founder and CEO of SageMedic.Dr. Apfel developed the Onca test, which can identify effective cancer therapies within a week by culturing tumor fragments, potentially doubling the odds of positive tumor response.Personal experience with his father's lung cancer led Dr. Apfel to question conventional treatments after discovering their low success rates for advanced cancers.The Onca test evaluates chemotherapies, targeted therapies, and repurposed drugs like statins and Metformin, which have shown promising results in cancer treatment.Tumor heterogeneity makes it crucial to obtain representative biopsy samples, particularly from metastatic sites, to avoid ineffective treatments.Patient advocacy is essential in cancer treatment, as patients need to make informed decisions about tissue handling before surgery and find oncologists willing to consider alternative treatments based on test results.----Grab my book A Better Way to Treat Cancer: A Comprehensive Guide to Understanding, Preventing and Most Effectively Treating Our Biggest Health Threat - https://www.amazon.com/dp/B0CM1KKD9X?ref_=pe_3052080_397514860 Unleashing 10X Power: A Revolutionary Approach to Conquering Cancerhttps://store.thekarlfeldtcenter.com/products/unleashing-10x-power-Price: $24.99-100% Off Discount Code: CANCERPODCAST1Healing Within: Unraveling the Emotional Roots of Cancerhttps://store.thekarlfeldtcenter.com/products/healing-within-Price: $24.99-100% Off Discount Code: CANCERPODCAST2----Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com

Trying to lower cholesterol, balance blood sugar, or burn more fat—but feel like nothing's working? In this episode, Dr. Bart shares one of his top clinical tools for metabolic health: Berberine Active. It's a powerful herbal supplement that's been shown to lower LDL and triglycerides, improve fat metabolism, support blood sugar regulation, and calm systemic inflammation. And best of all? Dr. Bart has real before-and-after lab results to prove it. In this episode: Why Berberine is being compared to Metformin—and often outperforms it The 5 powerful health benefits that make it Dr. Bart's go-to supplement How it impacts gut health, inflammation, fat storage, and insulin resistance Why lifestyle still matters—and how to pair Berberine with smart changes Real lab-backed results from patients in Dr. Bart's practice  

Send us a message with this link, we would love to hear from you. Standard message rates may apply.Prediabetes affects over one-third of Americans, yet 80% don't know they have it. We break down what this silent condition means for your health and provide practical strategies to prevent progression to diabetes.• Prediabetes is defined as blood sugar that's elevated but not high enough to be diabetes• Risk factors include being over 45, overweight, family history of diabetes, and certain racial backgrounds• Prediabetes independently increases risk for heart disease, stroke, and kidney disease• Losing just 7% of body weight and exercising 150 minutes weekly reduces diabetes risk by 58%• Even without weight loss, exercise alone cuts diabetes risk by 44%• Focus on whole foods, legumes, fruits, vegetables, and limiting processed foods• Poor sleep significantly increases diabetes risk—aim for 7-8 hours of quality sleep• Metformin may be recommended for higher-risk individuals• Prediabetes is reversible with lifestyle changesFollow our podcast and share this episode with a loved one—since one-third of Americans have prediabetes and most don't know it, you could help someone take control of their health before it's too late.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

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In this episode, we're spotlighting a surprising superstar in the world of thyroid health—metformin. That's right—the go-to medication for type 2 diabetes is now making waves in the Hashimoto's and hypothyroidism communities. But why?We'll break down how metformin works to regulate your blood sugar and boost insulin sensitivity—and more intriguingly—how emerging research shows it may also help reduce autoimmune antibodies, support healthier thyroid hormone levels, improve gut health, and even aid with weight loss.Could metformin be a game-changer for your thyroid? You'll want to listen to this issue, and join us for this deep dive into the benefits, potential side effects, and what you must know before considering it as part of your treatment plan. Need more information? Learn more at the Paloma Health blog:Metformin, Hashimoto's, and Hypothyroidismhttps://www.palomahealth.com/learn/metformin-hashimotos-hypothyroidism Does Metformin Cause Weight Loss With Hypothyroidism?https://www.palomahealth.com/learn/hypothyroidism-weight-loss-metformin About Paloma Health:⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused exclusively on treating hypothyroidism. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. Become a Paloma Member:https://www.palomahealth.com/pricing-hypothyroidism Paloma Complete Thyroid Blood Test Kit:https://www.palomahealth.com/home-thyroid-blood-test-kit

Everyone wants to live longer and feel better, but the flood of information on supplements, drugs, and fitness can feel overwhelming.I invited Siim Land, an expert and 8-time bestselling author on longevity, to cut through the noise and share simple, evidence-based strategies that really move the needle when it comes to health and lifespan.Siim shares incredible, science-based tips on how we can enhance our healthspan and lifespan without getting lost in the hype.We dig into why exercise, especially combining strength training with cardio, is the single most powerful anti-aging tool. Siim explains how even small changes in daily activity can dramatically reduce your risk of chronic disease and help you live longer.We also talk about what everyone is curious about - Rapamycin, Metformin, Senolytics, and more - and I'm excited to share what the research really says about these popular longevity compounds. Siim also shares why having strong social relationships may be even more important than any pill.If you want clear, practical guidance on living healthier and longer, this episode is for you. Click play and join us for a deep dive into real, sustainable longevity strategies!Key Takeaways:Introduction (00:00)Siim Land's background and journey to longevity (00:30)Exercise is the top anti-aging intervention (05:31)Benefits of moderate daily activity (08:38)Importance of resistance training for muscle and metabolism (10:42)Cardiorespiratory fitness explained with heart rate zones (15:24)Thoughts on supplement overload and key supplements (26:19)Concerns about fish oil oxidation (29:06)Sunscreen vs antioxidants debate (35:53)Senolytics and longevity drugs overview (39:05)Metformin benefits (43:15)Calorie restriction and body composition for longevity (47:11)Social relationships are key to life satisfaction (50:18)Additional Resources: ✨ Connect with Siim LandBooks: https://www.amazon.com/stores/Siim-Land/author/B019H1Z14M?Instagram: https://www.instagram.com/siimland/?hl=enFacebook: https://www.facebook.com/thesiimlandYouTube: https://www.youtube.com/c/siimland—✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

I'm diving deep with Regan Archibald, an absolute peptide and regenerative medicine genius to unearth mind-blowing therapies that fight aging, melt fat, heal your body, and sometimes even help you skip surgery entirely. If you're tired, feeling older than your age, or frustrated that traditional protocols aren't moving the needle, you need to hear this. We break down why most people barely scratch the surface when it comes to peptides and why these little protein messengers are the secret to amplifying your results—think faster gut healing, squashing mold toxicity, supercharging immune resilience, and getting you vibrant again on a cellular level. From innovative gut-healing protocols to stacking the right peptides for real transformation, Reagan drops gems that will completely shift your expectations about how fast and radically you can upgrade your health. We also talk muscle preserving, fat-burning, body composition-boosting peptide stacks, and why Rapamycin and Metformin could be sabotaging your muscle building goals as you age. Think next level breakthroughs: exosomes, stem cells and the new world of plasma renewal therapy that's basically an oil change for your blood. Whether you're struggling with pain, aiming for a killer physique, or curious about brain optimization and the future of longevity medicine, this episode is packed with protocols, client stories and takeaways that just might blow your current health plan out of the water. Work with Regan Archibald and his Team https://acueastwest.com/ WHAT DO MY LABS MEAN?! Try the ultimate tool to Decode Your Labs: Understand your thyroid, hormones, and blood sugar numbers to transform your health https://dramie.com/labs/ We prescribe to all 50 states!  When you're ready to FINALLY get the help you deserve… Book a free application call: https://dramie.com/book-a-call/ Shop ALL of Dr. Amie's Fixxr® Supplements: https://betterlifedoctor.com/ EARN CE Credits: "Nurses, hold-on  – here comes the exciting part: you can earn nursing CE credits by listening to our podcasts! That's right—RNegade has teamed up with podcast hosts like me who are delivering amazing content that doesn't limit you to “thinking outside-the box,” it challenges you to BLOW-UP the box by learning from innovators, pioneers, and RENEGADES in the field of health and medicine WHILE EARNING YOUR CEs!” https://rnegade.thinkific.com/?ref=4d98d0 RATE, REVIEW AND FOLLOW ON APPLE PODCASTS If you made it this far I'm impressed! That means you really love the show and I love you for that!  So I'm going to ask you for a favor. Would you please leave a quick review or even 5⭐️. I DO read them and can't tell you how much I appreciate it! Thank you in advance!❤️  Just click here it's quick and easy : https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263,  Ok ONE MORE favor…would you please subscribe and follow the show? This is a win-win! It tells the podcast powers that be that you like The Thyroid Fixer Podcast AND it lets you catch all the new episodes that come out every week. Follow with this link: https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263 and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Want to get your labs reviewed and your questions answered LIVE by me? Join my exclusive Facebook group, Just Fix Your Thyroid – a supportive and empowering community designed to give you the tools, guidance, and HOPE you need on your thyroid and hormone journey.

In this solo episode of The Red Light Report, Dr. Mike explores the profound connection between mitochondrial health and oral disease. He reviews three recent studies highlighting how red light therapy, methylene blue, and compounds like urolithin A can support oral tissues, reduce inflammation, and even impact systemic conditions like diabetes and neurodegeneration. From root canal innovations to mitophagy in periodontitis, this episode is full of cutting-edge insights and practical applications for anyone interested in longevity, biohacking, or oral health optimization.Key Topics Covered:Study #1: Methylene Blue + Graphene Oxide for Root Canal Photodynamic Therapy• Combining methylene blue and reduced graphene oxide with red light therapy significantly improves antibacterial and antifungal effects in root canals.• Highlights the synergy between methylene blue and red light.• Dr. Mike shares how his nighttime routine—using BioBlue Calm and a red-light toothbrush—may create a low-level photodynamic therapy effect in the mouth.Study #2: Mitophagy in Periodontal Disease• Mitophagy (mitochondrial autophagy) plays a key role in managing inflammation, bone remodeling, and cell death in gum disease.• Key interventions to enhance oral mitophagy:• Urolithin A (strong Pink1/Parkin pathway activator)• Resveratrol, Melatonin (support mitochondrial quality)• Berberine, Curcumin, Metformin (via AMPK activation)• NR, Quercetin (via SIRT1 + PGC-1α pathway)Study #3: Mitochondrial Dysfunction Links Oral and Systemic Diseases• Periodontitis driven by mitochondrial dysfunction is linked to diseases like diabetes, cardiovascular disease, and neurodegeneration.• Key issues:• Impaired mitochondrial fusion/fission, biogenesis, and mitophagy.• Excessive ROS and mitochondrial DNA leakage fuel inflammation.• Poor mitochondrial function impairs periodontal stem cell regeneration.• Therapeutic approaches:• Antioxidants (CoQ10, resveratrol, melatonin, curcumin, EGCG)• Photodynamic therapy (methylene blue + red light)• Mitochondria-targeted compounds to modulate apoptosis and inflammation.Dr. Mike's Takeaways• Oral mitochondrial health is foundational—not isolated from systemic health.• Red light therapy and methylene blue offer powerful synergistic effects, even in oral applications.• A mitochondria-first approach may provide long-term protection against oral and systemic disease.   If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key points: 00:00 – Introduction: Mitochondrial Health & Podcast Focus 00:32 – Announcements: Health Alchemy Bundle & Upcoming Events 06:18 – Study 1: Methylene Blue & Red Light Therapy for Root Canal Treatment 08:42 – Methylene Blue Benefits Recap 13:37 – Study 1 Discussion: Photodynamic Therapy Enhancements 16:57 – Practical Application: Methylene Blue for Oral Health 19:40 – Study 2: Mitophagy in Periodontal Disease 23:46 – Targeted Mechanisms to Enhance Mitophagy 28:42 – Study 3: Mitochondrial Dysfunction in Periodontitis & Systemic Diseases 31:38 – Therapeutic Strategies for Mitochondrial Health 41:44 – Integrative Mitochondrial Therapies 47:02 – Conclusion: Mitochondrial Dysfunction as a Core Issue 50:45 – Closing Thoughts & Upcoming Events - Articles referenced in episode:Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatmentMitophagy and Its Significance in Periodontal DiseaseMitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies - Get over $6,000 worth of wellness education from top experts for $50! The Health Alchemy BundleThis is an amazing opportunity put together by Carrie Bennett and Sarah Kleiner! This Bundle is collection of 60+ eBooks, courses, and other resources available for $50 at a mind-blowing 99% discount.     This massive collection of resources is rooted in the science + spirituality of healing with nature, which cover topics like: Circadian & quantum biology Mental, emotional, & spiritual health Nutrition, minerals, & supplementation (when necessary) Herbalism & homeopathy Movement, posture, & fitness Hormonal health, pregnancy, & parenting And even specific issue support—from healing autoimmunity to improving sleep, & more This is a limited opportunity that goes through TOMORROW, May 23rd, so act now and don't miss out!   Get The Health Alchemy Bundle by clicking here! - Upcoming BioLight Events:   Biohacking Conference - May 28 - 30 (Austin, TX)   Returning to Nature (Quantum Health Retreat), June 26 - 27 (Franklin, TN) - Introducing the Newest BioBlue Supplement! The most comprehensive, powerful mitochondrial support supplement on the market ...   What is The Fountain of Youth in simple terms? An unparalleled supplement for brain power, energy, and longevity This supplement is like a high-performance tune-up for your brain and body. It combines powerful natural and science-backed ingredients to help you think clearer, feel more energized, and support your long-term health.The BioBundle automatically saves you 15% on both of the supplements you choose.   For the next two weeks, SAVE 20% on your order of BioBlue Fountain of Youth! Simply use code FOY20 Code expires 5/29, midnight PST   Click here to check out BioBlue Fountain of Youth - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

Joe Biden's advanced prostate cancer diagnosis I'm prediabetic, and my doctor wants to start me on Metformin. What are your thoughts? Is it a good idea to take metformin for its anti-aging benefits?

In this episode, Dr. Adam Rinde welcomes back microbiologist and PolyBio Research Foundation co-founder Dr. Amy Proal. Together, they unravel a framework for understanding chronic illnesses through the lens of persistent infections and their impact on mitochondria, immunity, and neurological health.Dr. Proal shares cutting-edge research linking pathogens like herpesviruses, cytomegalovirus, Epstein-Barr, and even latent parasites to conditions like Alzheimer's, long COVID, chronic fatigue syndrome, POTS, and more. Discover how stealth microbes can disrupt the vagus nerve, hijack mitochondrial energy systems, and weaken immune responses, setting the stage for a cascade of chronic dysfunctions.The conversation dives deep into the role of immune modulation, including promising findings around low-dose rapamycin and its potential to restore immune signaling and combat viral persistence. They also explore diet, metabolic interventions, and new clinical trials shaping the future of treatment.Whether you're a patient, practitioner, or curious mind, this episode offers profound insight into the evolving science of chronic illness and hope for emerging therapies.

Send us a textDr. Holly Thacker dives deep into the world of endocrinology and anti-aging with guest Dr. Elena Christofides. Dr. Christofides highlights how hormonal health significantly impacts women's well-being as they age. The discussion covers common health challenges women face, potential treatments, and the importance of personalized assessments to optimize health through lifestyle and pharmacological means. • Explanation of endocrinology and its roles in overall health • Common health concerns for midlife women • Importance of understanding aging vs. hormonal imbalance • Overview of Metformin and emerging treatments like rapamycin • The significance of mitochondrial health • Connection between environmental factors and health optimization • Empowerment through health advocacy and informed choices For more information on Dr. Elena Christofides, visit endocrinology-associates.com. You can listen to Dr. Christofides podcast on medcentral.com.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts SpotifySupport the show

The FiltrateJoel TopfAC GomezSophia AmbrusoNayan AroraSpecial Guest Charles Edelstein, MD, PhD Professor, Medicine-Renal Med Diseases/HypertensionExtra-Special GuestMichelle Rheault, MD Professor of Pediatrics, University of MinnesotaEditing bySimon and Joel TopfThe Kidney Connection written and performed by by Tim YauShow NotesKDIGO ADPKD Guidelines:WebsiteGuideline PDFExecutive Summary PDFNephJC coverageConsortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)Hy's Law (Wikipedia) has three components:ALT or AST by 3-fold or greater above the upper limit of normalAnd total serum bilirubin of greater than 2× the upper limit of normal, without findings of cholestasis (defined as serum alkaline phosphatase activity less than 2× the upper limit of normal)And no other reason can be found to explain the combination of increased aminotransferase and serum total bilirubin, such as viral hepatitis, alcohol abuse, ischemia, preexisting liver disease, or another drug capable of causing the observed injuryMeeting this definition yields a very high risk of fulminant kidney failure (76% in one series)Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database (PubMed) Two of 957 patients on tolvaptan met Hy's law criteria. None had fulminant kidney failure.Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial (PubMed) Patients had a baseline urine volume on tolvaptan of 6.9 L/24 h. Urine volume decreased to 5.1 L/24 h with hydrochlorothiazide and to 5.4 L/24 h on metformin.TEMPO 3:4 Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease (NEJM)Reprise Trial Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease ( NEJM | NephJC )Unified ultrasonographic diagnostic criteria for polycystic kidney disease by Edelstein in JASN (PubMed)Tolvaptan and Kidney Function Decline in Older Individuals With Autosomal Dominant Polycystic Kidney Disease: A Pooled Analysis of Randomized Clinical Trials and Observational Studies (PubMed)Charles' draft choice Recommendation 4.1.1.1: We recommend initiating tolvaptan treatment in adults with ADPKD with an estimated glomerular filtration rate (eGFR) ‡25 ml/min per 1.73 m2 who are at risk for rapidly progressive disease (1B).Sophia's draft choice Recommendation 1.4.2.1: We recommend employing the Mayo Imaging Classi cation (MIC) to predict future decline in kidney function and the timing of kidney failure (1B).Progression to kidney failure in ADPKD: the PROPKD score underestimates the risk assessed by the Mayo imaging classification (Frontiers of Science)AC's draft choice Recommendation 9.2.1: We recommend targeting BP to ≤ 50th percentile for age, sex, and height or ≤ 110/70 mm Hg in adolescents in the setting of ADPKD and high BP (1D).HALT-PKD Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease (NEJM)Nayan's draft choice Recommendation 6.1.2: We recommend screening for ICA in people with ADPKD and a personal history of SAH or a positive family history of ICA, SAH, or unexplained sudden death in those eligible for treatment and who have a reasonable life expectancy (1D).Screening for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease (CJASN)Surgical Clipping Versus Endovascular Coiling in the Management of Intracranial Aneurysms (PubMed) Clipping is associated with a higher rate of occlusion of the aneurysm and lower rates of residual and recurrent aneurysms, whereas coiling is associated with lower morbidity and mortality and a better postoperative course.Joel's editorial pick Recommendation 6.1.1: We recommend informing adults with ADPKD about the increased risk for intracranial aneurysms (ICAs) and subarachnoid hemorrhage (1C).Joel's first draft pick The bring out your dead pick:Recommendation 4.3.1: We recommend not using mammalian target of rapamycin (mTOR) inhibitors to slow kidney disease progression in people with ADPKD (1C).Recommendation 4.4.1: We suggest not using statins specfiically to slow kidney disease progression in people with ADPKD (2D).Recommendation 4.5.1: We recommend not using metformin specifically to slow the rate of disease progression in people with ADPKD who do not have diabetes (1B).Recommendation 4.6.1: We suggest that somatostatin analogues should not be prescribed for the sole purpose of decreasing eGFR decline in people with ADPKD (2B).Perfect match: mTOR inhibitors and tuberous sclerosis complex (Orphanet Journal of Rare Diseases)Navitor Pharmaceuticals Announces Janssen Has Acquired Anakuria Therapeutics, Inc. (BioSpace) This is press release about acquiring the mTor1 inhibitor.Joel's second draft pick Recommendation 4.2.1.1: We suggest adapting water intake, spread throughout the day, to achieve at least 2–3 liters of water intake per day in people with ADPKD and an eGFR ≥ 30 ml/min per 1.73 m2 without contraindications to excreting a solute load (2D).Nayan's bonus draft Practice Point 4.7.1: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) should not be used to slow eGFR decline in people with ADPKD.Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan (KIReports)SMART Trial of GLP-1ra in non-diabetics: Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial (PubMed)Tubular SecretionsNayan: Landman on Paramount Plus (IMDB)Sophia: PassNayan: steps in with The Pitt on HBO (Wikipedia)Charles: The White Lotus, Yellowstone 1923, Poirot (IMDB)AC: The PittMichael Crichton's Estate Sends The Pitt to the Courtroom (Vulture)Joel: I Must Betray you by Ruta Sepetys (Amazon)

In this episode, we explore the potential role of the probiotic Akkermansia muciniphila in managing olanzapine-induced weight gain. Could this tiny gut bacterium be the key to maintaining metabolic health while on antipsychotics? Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.5 CME: Quick Take Vol. 67 Olanzapine-Induced Weight Gain: Can Akkermansia Muciniphila Help?

Welcome to The Superhumanize Podcast.I'm your host, Ariane Sommer—and in this episode, we explore a frontier of health that's been quietly shaping our biology all along: the world of glycans.My guest is Nikolina Lauc, co-founder and CEO of GlycanAge—a pioneering biotech company using glycan biomarkers to measure biological age and predict long-term health outcomes. Her work is helping to shift the paradigm of aging from something we passively endure to something we can actively understand—and even influence.We dive into what glycans are—these complex sugar molecules that modify proteins and silently direct processes like inflammation, immunity, and aging.Nikolina explains how they reveal a layer of biological communication most of us have never heard of… and how listening to that hidden language can help us prevent disease years before it begins.We also explore GlycanAge's breakthrough menopause biomarker, their personalized approach to longevity, and what it means to raise awareness around women's health in a data-driven age.If you've ever wanted to go deeper than genetics—If you've sensed there's more to your body's story than your DNA—This episode may open a new door for you.Episode highlights:-What glycans are and why they matter more than genes alone-How chronic inflammation predicts disease up to 10 years in advance-The science behind GlycanAge's biological age test-Why exercise and diet affect everyone differently-The coming revolution in menopause diagnostics-Metformin, biohacking, and the myth of one-size-fits-all longevity-The future of personalized health data and ethical enhancementResources mentioned:Glycan Age https://glycanage.com/Guest's social handles:Nikolina LaucLinkedIn https://www.linkedin.com/in/nikolinalaucInstagram https://www.instagram.com/nikolinalauc/Glycan AgeInstagram https://www.instagram.com/glycanage/X https://x.com/glycanageFacebook https://www.facebook.com/glycanage/YouTube https://www.youtube.com/channel/UCn1OeXYKa-NmKr9AtczwN4Q

1. High-intensity interval training (HIIT)Just a few minutes of high-intensity exercise with lots of rest can quickly deplete excess sugar in your blood. Try doing exercises such as burpees, plyometrics, or a spin bike.2. Apple cider vinegarApple cider vinegar contains acetic acid, which can slow down a blood sugar spike after consuming sugar. Combine one tablespoon of apple cider vinegar with 8 ounces of water and drink this after a high-carb meal. 3. Berberine, NAC, and other supplementsBerberine is considered a natural Metformin without the side effects. You can pair berberine with NAC or alpha lipoic acid for more natural blood sugar support. Excess carbs deplete vitamin B1, so if you have a cheat meal or fall off the wagon with carbohydrates, increase vitamin B1.4. Post-meal walkA 25 to 30-minute post-meal walk can help burn off excess sugar so that it is not converted into cholesterol or stored as fat. 5. Potassium and magnesiumPotassium is necessary for glucose storage in the liver and the muscles. It also helps move glucose into your cells. Magnesium is critical for the cells that produce insulin. Nearly every diabetic is deficient in magnesium!6. Ketone supplements Providing the brain with ketones supports healthy blood sugar in the brain, which can improve cognitive function and decrease brain fog. 7. Saltwater Sodium helps prevent stress-induced blood sugar spikes. Adding more salt to your last meal or adding it to a glass of water can improve sleep and calm your mood.Dry fasting can lower blood sugar faster than anything else! Dry fasting means you're not drinking water or eating food. When you're dry fasting, your body increases the hormone glucagon, which helps to lower blood sugar. Growth hormone and antioxidants also increase, and your body quickly switches to fat-burning.Dr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media.

Dr. Hoffman continues his conversation with Dr. Jacob Teitelbaum, Integrative Medicine physician, researcher, and best-selling author.

Diabetes Deep Dive: Dr. Jacob Teitelbaum, an integrative medicine physician and author, discusses diabetes from a multifaceted perspective. They explore the connections between diabetes, chronic fatigue syndrome, fibromyalgia, sleep disorders, metabolic syndrome, and long COVID. Dr. Teitelbaum offers insights into the historical emergence of diabetes in correlation with lifestyle and dietary changes, particularly the Western diet's high sugar and low fiber content. They discuss the roles of vitamin D, magnesium, and other nutrients, as well as the impact of chemicals on metabolism. The conversation also covers the importance of sleep, stress management, and lifestyle adjustments. Dr. Teitelbaum recommends natural supplements like Sucontral D, berberine, and melatonin to manage blood sugar levels effectively. The episode concludes with a discussion on the controversial role of pharmaceutical interventions like GLP-1 drugs and insulin. Dr. Teitelbaum emphasizes a balanced, integrative approach that empowers self-care and holistic health management.

Today, we're going to talk about the best drinks for diabetes management and prevention to support healthy blood sugar as you sleep. These 7 drinks help improve sleep quality by preventing troublesome issues like night waking and nighttime urination.Blood sugar often decreases at night, increasing cortisol, which increases blood sugar levels. Poor sleep can also cause blood sugar issues, and frequent urination at night can contribute to this problem.Here are 7 nighttime drinks to help stabilize blood sugar levels throughout the night. Try these drinks to support healthy blood sugar levels and improve sleep. 1. Apple cider vinegar with cinnamonAdd one to two tablespoons of apple cider vinegar with a pinch of cinnamon to a glass of water for the perfect blood sugar-balancing drink.2. Chamomile teaChamomile tea lowers cortisol and stabilizes blood sugar by directly supporting the cells in the pancreas.3. Golden milkCombine turmeric and ginger with milk to make a delicious blood sugar-balancing latte. 4. Aloe vera juiceAloe vera is known to help with digestion and ulcers and can be applied topically to wounds, but it also potently affects the cells that make insulin.5. Berberine teaThis herb is close in effectiveness to Metformin, just without the side effects!6. Electrolyte drinks (without sugar)Potassium and magnesium are vital for healthy blood sugar levels. Magnesium can significantly decrease cortisol, while potassium can reduce blood sugar and is essential for glucose storage in the liver and the muscles. Most people are not getting enough potassium!7. Salt in waterSodium is an important electrolyte that helps reduce blood sugar and cortisol. Add it to water or your electrolyte drinks to help increase hydration. It also supports the adrenal glands, nerves, and muscles. Dr. Eric Berg DC Bio:Dr. Berg, age 59, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media.

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Story at-a-glance A study that analyzed 52,501 Type 2 diabetes patients found widespread nutrient deficiencies, with vitamin D being most common (60.45%), followed by magnesium (41.95%) and vitamin B12 (28.72%) Vitamin D deficiency significantly impairs insulin function and sensitivity, while increasing the risk of complications like diabetic retinopathy, kidney disease and foot ulcers Magnesium deficiency creates a vicious cycle among diabetics — low intake increases diabetes risk, while diabetes increases magnesium loss through urination, leading to poorer glycemic control Metformin, the most prescribed diabetes medication, depletes vitamin B12 levels by interfering with B12 absorption, which can lead to nerve damage, numbness and fatigue Geographic location influences deficiency rates, with the Americas showing the highest prevalence at 54.04% of diabetes patients having at least one micronutrient deficiency

In this Huberman Lab Essentials episode, I explore how the nervous system impacts fat loss and how certain behaviors and supplements can accelerate fat burning. I explain how non-exercise movements like fidgeting and shivering trigger adrenaline to boost fat metabolism. I also examine the impact of exercise intensity and fasted workouts on fat burning, and how supplements such as caffeine, GLP-1 and berberine can further support fat loss. These science-based tools go beyond traditional calorie counting to enhance metabolism and improve body composition. Huberman Lab Essentials are short episodes (approximately 30 minutes) focused on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, and our full-length episodes will still be released every Monday. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Huberman Lab Essentials; Fat Loss 00:01:00 Calories In, Calories Out; Nervous System 00:02:57 Fat Burning, Nervous System & Adrenaline 00:06:31 Sponsor: David 00:07:45 Increase Adrenaline, Shivering, Tool: Fidgeting 00:11:25 Shivering & Fat Loss, White & Brown Fat 00:14:42 Tool: Deliberate Cold Exposure Protocol 00:16:43 Sponsor: AG1 00:18:38 High, Medium vs Low-Intensity Exercise, Exercise Fasted? 00:24:30 Tool: Exercise for Fat Loss; Adrenaline 00:27:18 Sponsor: LMNT 00:28:34 Caffeine, Dose, Exercise & Fat Loss 00:30:17 GLP-1, Yerba Mate, Exercise; Semaglutide 00:33:16 Berberine, Metformin, Insulin 00:34:12 Diet, Adherence, Carbohydrates & Insulin 00:35:52 Recap & Key Takeaways Disclaimer & Disclosures

Metabolic syndrome (MetSyn) is a cluster of conditions, such as increase in waist circumference, dyslipidemia (elevated triglyceride levels and reduced HDL), increased blood pressure, and increased fasting blood sugar levels that is related to insulin resistance, diabetes, and elevated risk of cardiovascular disease. Women with PCOS have a significantly higher prevalence of metabolic syndrome (MetS) compared to the general population, with studies indicating a prevalence of around 43-47% in PCOS women. PLUS, there is a high prevalence of moderate to severe depressive symptoms and depression in adults and adolescents with PCOS; therefore, screening for depression in all adults and adolescents with PCOS is encouraged. In this episode, we will review a new publication for the J Clinical Endo & Metabolism discussing this combination (PCOS and depression/anxiety) and the MetSyn, and we will review the EXPANDED indications for metformin for metabolic syndrome prevention/treatment according to the 2023 PCOS updated guidance.

In this Huberman Lab Essentials episode, I explain how hormones regulate hunger, appetite and feelings of satiety (fullness), along with strategies to help control appetite. I describe how the body senses nutrient levels and how the brain processes these signals to stimulate hunger or suppress appetite. I also discuss how certain foods can help curb hunger, while processed foods and emulsifiers can interfere with satiety signals, leading to overeating. Additionally, I cover how lifestyle factors such as exercise and meal timing regulate blood glucose levels, which in turn impact hunger and appetite. Huberman Lab Essentials episodes are approximately 30 minutes long and focus on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, while our full-length episodes will continue to be released every Monday. This Huberman Lab Essentials is from the full-length Huberman Lab episode, “How Our Hormones Control Our Hunger, Eating & Satiety.” Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David Protein: https://davidprotein.com/huberman Mateina: https://drinkmateina.com/huberman LMNT: https://drinklmnt.com/huberman For all Huberman Lab sponsors, visit hubermanlab.com/sponsors. Timestamps 00:00:00 Huberman Lab Essentials; Hunger & Appetite 00:00:56 Hunger, Hypothalamus, Cortex & Mouth 00:04:46 Sponsor: David Protein 00:06:02 Melanocyte-Stimulating Hormone, AgRP Neurons, Ghrelin, Tool: Regular Meal Timing 00:10:13 Cholecystokinin (CCK), Tool: Omega-3s, Amino Acids & Blunting Appetite 00:13:26 Sponsor: AG1 00:14:30 Highly-Processed Foods, Emulsifiers, Tool: Whole Foods & Satiety Signals 00:19:10 Insulin, Glucose, Type 1 & 2 Diabetes 00:22:16 Sponsor: Mateina 00:23:41 Insulin & Glucagon, Tools: Food Order, Movement & Blood Glucose 00:27:26 Tool: Exercise & Stable Blood Sugar 00:29:38 Metformin, Ketogenic Diet, Blood Glucose 00:31:59 Sponsor: LMNT 00:33:16 Diabetes, Urine & Blood Sugar 00:35:40 Caffeine, Tool: Yerba Mate, Glucagon-Like Peptide -1 (GLP-1), Appetite 00:38:49 Recap & Key Takeaways Disclaimer & Disclosures

Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating. What You'll Learn: • The optimal fasting window for maximizing lifespan (Hint: It's not 16 hours) • The four fasting metabolites that extend life by 96% • How Mimio mimics fasting benefits—without giving up food • The real reason over-fasting destroys your metabolism and hormones • Why traditional longevity drugs (Metformin, Rapamycin) fall short • Can you build muscle and burn fat at the same time? The science of mTOR & AMPK • Why Big Pharma doesn't want you to know about this breakthrough *** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE *** Sponsors:Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mimio Instagram: https://www.instagram.com/mimiohealth/ • Mimio Website: https://mimiohealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:58 – Fasting & Longevity • 01:88 – Optimal Fasting Length • 03:39 – Alternate Day Fasting: Pros & Cons • 05:50 – Key Fasting Compounds • 07:34 – Spermidine & Longevity Molecules • 11:41 – FDA Roadblocks on Natural Compounds • 15:37 – AI, Big Data & Longevity Research • 31:19 – Mimio's Impact on Testosterone & Aging • 35:16 – Longevity & Death Philosophy • 36:48 – Biohacking Origins • 37:03 – Metabolism & Cognitive Function • 38:35 – Unexpected Effects of Fasting • 40:43 – Fasting & Circadian Rhythms • 43:09 – Mimio Science & Benefits • 45:14 – Mimio in a Daily Routine • 55:05 – Men vs. Women: Fasting Differences • 01:02:23 – Future of Nutrition & Biohacking • 01:07:21 – Conclusion & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Ralph DeFronzo is a distinguished diabetes researcher and clinician whose groundbreaking work on insulin resistance has reshaped the understanding and treatment of type 2 diabetes. In this episode, Ralph shares insights from his five decades of research, including his pivotal role in bringing metformin to the U.S. and developing SGLT2 inhibitors. Ralph explores the impacts of insulin resistance on specific organs, the pharmacologic interventions available, and the gold-standard euglycemic clamp method for measuring insulin resistance. This episode is a masterclass in the pathophysiology and treatment of type 2 diabetes, featuring an in-depth discussion of GLP-1 receptor agonists, metformin, and a lesser-known class of drugs that opened Peter's eyes to new possibilities in diabetes care. We discuss: Metabolic disease as a foundational driver of chronic illness [4:00]; Defining insulin resistance: effects on glucose, fat, and protein metabolism, and how it varies between healthy, obese, and diabetic individuals [8:15]; The historical significance of the development of the euglycemic clamp technique for measuring insulin resistance [11:45]; How insulin affects different tissues: liver, muscle, and fat cells [15:00]; The different ways insulin resistance manifests in various tissues: Alzheimer's disease, cardiovascular disease, and more [25:00]; The dangers of hyperinsulinemia, and the importance of keeping insulin levels within a physiological range [29:00]; The challenges of identifying the genetic basis of insulin resistance and type 2 diabetes [37:00]; The “ominous octet”—a more comprehensive model of type 2 diabetes than the traditional triumvirate [45:45]; The kidneys' unexpected role in worsening diabetes, and how SGLT2 inhibitors were developed to treat diabetes [55:45]; How insulin resistance in the brain and neurocircuitry dysfunction contribute to overeating and metabolic disease [1:04:15]; Lipotoxicity: how overeating fuels insulin resistance and mitochondrial dysfunction [1:07:30]; Pioglitazone: an underappreciated and misunderstood treatment for insulin resistance [1:10:15]; Metformin: debunking the misconception that it is an insulin sensitizer and explaining its true mechanism of action [1:19:15]; Treating diabetes with triple therapy vs. the ADA approach: a better path for diabetes management [1:24:00]; GLP-1 agonists, the Qatar study, and rethinking diabetes treatment [1:31:30]; Using a hyperglycemic clamp to look for genes that cause diabetes [1:45:15]; The superiority of measuring C-peptide instead of insulin to assess beta-cell function [1:46:45]; How GLP-1-induced weight loss affects muscle mass, the benefits and risks of myostatin inhibitors, and the need for better methods of evaluating functional outcomes of increased muscle mass [1:51:30]; The growing crisis of childhood obesity and challenges in treating it [2:02:15]; The environmental and neurological factors driving the obesity epidemic [2:07:30]; The role of genetics, insulin signaling defects, and lipotoxicity in insulin resistance and diabetes treatment challenges [2:11:00]; The oral glucose tolerance test (OGTT): detecting early insulin resistance and beta cell dysfunction [2:18:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube