Podcasts about Metformin

What if your body had built-in tools to regenerate itself but you've been looking in the wrong places? Dr. Khoshal Latifzai reveals overlooked therapies like peptides, shockwave, stem cells, & ketamine that go beyond symptom masking. He explains how athletes & longevity seekers use diagnostics, fasting, & advanced biologics to stay ahead of aging & feel better, faster. Meet our guest Dr. Khoshal Latifzai is a Yale-trained, board-certified emergency physician who founded Rocky Mountain Regenerative Medicine to focus on prevention, longevity & performance. Inspired by his humanitarian work & experience in critical care, he blends advanced biologics, hormone optimization & regenerative therapies to treat pain, enhance vitality & extend healthspan. His personalized approach serves athletes, executives & anyone seeking to thrive at every stage of life. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Track biomarkers regularly through frequent, detailed bloodwork to personalize health strategies & catch negative effects early Cycle medications & supplements like peptides & metformin to prevent tolerance & maintain effectiveness Personalize metformin use since benefits, dosing & side effects vary Use low-dose rapamycin for potential longevity benefits, monitoring closely with regular biomarker testing Go beyond standard panels by checking ApoB, Lp(a) & homocysteine for better insight into cardiovascular risk Question outlier biomarkers like A1C by considering factors such as red blood cell lifespan before making assumptions Use ketamine therapy under supervision to address depression & anxiety when conventional treatments fall short Trigger targeted repair in joints or tissues using shockwave therapy to activate local stem cell healing Bank stem cells early while they're younger & more effective to improve outcomes for future injuries or illnesses Support stem cell health with regular fasting, exercise & optimized metabolic function to maintain potency with age Episode Highlights 09:39 Metformin & Rapamycin for Longevity 16:53 Underrated Biomarkers & Diagnostics 24:23 Ketamine Therapy for Brain Remodelling 45:30 Shockwave & Stem Cell Therapy Deep Dive   Links Watch it on YouTube: https://youtu.be/UbA4DzzNqN0  Full episode show notes: outliyr.com/214 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

In this podcast episode of Integrative Cancer Solutions Dr. Karlfeldt interviews Dr. Chris Apfel about his integrative approaches to cancer treatment. Dr. Apfel shares his journey from traditional medicine to integrative oncology, sparked by his father's lung cancer diagnosis. This personal experience led him to question conventional cancer treatments after learning about their low success rates, particularly for stage four lung cancer. Dr. Apfel discusses his development of the Onca test, which can identify effective cancer therapies within a week by culturing tumor fragments. This test evaluates a wide range of treatments including chemotherapies, targeted therapies, and repurposed drugs. He emphasizes the importance of avoiding ineffective treatments that can harm the immune system and diminish quality of life, while highlighting the potential of repurposed drugs like statins, Metformin, and Itraconazole. The conversation addresses tumor heterogeneity and the need for representative biopsy samples, particularly from metastatic sites. Dr. Apfel explains that the Onca test is commercially available, with discounts offered to patients willing to share their data for research purposes. He discusses various methods for obtaining tumor samples and the importance of timing in the collection process.Dr. Apfel emphasizes patient advocacy and the need for patients to be informed about their treatment options. He notes that the Onca test can double the odds of a positive tumor response and significantly increase median survival rates. The podcast concludes with Dr. Apfel expressing interest in collaborating with Dr. Folt's center to help more cancer patients through this innovative approach to personalized cancer treatment.About Dr Chris Apfel:Chris Apfel, MD, PhD, MBA is a physician and clinical researcher with over 100 published papers, including a six-factor clinical prediction model published in NEJM that led to the development of The Apfel Score, a clinical calculator used universally to predict the risk of postoperative nausea and vomiting, and Dr Apfel's ultimate recruitment to the US and the University of California, San Francisco.Dr. Apfel was driven to revolutionize the field of cancer patient treatment after losing his mother to a long battle with ovarian cancer and his father to lung cancer. Witnessing their suffering inspired him leave the clinical department at UCSF to develop more efficient ways to identify the best treatment plans for cancer patients.Dr Apfel received his MD and PhD from the University of Giessen in Germany and his MBA from Wharton at the University of Pennsylvania. He is the founder and CEO of SageMedic.Dr. Apfel developed the Onca test, which can identify effective cancer therapies within a week by culturing tumor fragments, potentially doubling the odds of positive tumor response.Personal experience with his father's lung cancer led Dr. Apfel to question conventional treatments after discovering their low success rates for advanced cancers.The Onca test evaluates chemotherapies, targeted therapies, and repurposed drugs like statins and Metformin, which have shown promising results in cancer treatment.Tumor heterogeneity makes it crucial to obtain representative biopsy samples, particularly from metastatic sites, to avoid ineffective treatments.Patient advocacy is essential in cancer treatment, as patients need to make informed decisions about tissue handling before surgery and find oncologists willing to consider alternative treatments based on test results.----Grab my book A Better Way to Treat Cancer: A Comprehensive Guide to Understanding, Preventing and Most Effectively Treating Our Biggest Health Threat - https://www.amazon.com/dp/B0CM1KKD9X?ref_=pe_3052080_397514860 Unleashing 10X Power: A Revolutionary Approach to Conquering Cancerhttps://store.thekarlfeldtcenter.com/products/unleashing-10x-power-Price: $24.99-100% Off Discount Code: CANCERPODCAST1Healing Within: Unraveling the Emotional Roots of Cancerhttps://store.thekarlfeldtcenter.com/products/healing-within-Price: $24.99-100% Off Discount Code: CANCERPODCAST2----Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com

Trying to lower cholesterol, balance blood sugar, or burn more fat—but feel like nothing's working? In this episode, Dr. Bart shares one of his top clinical tools for metabolic health: Berberine Active. It's a powerful herbal supplement that's been shown to lower LDL and triglycerides, improve fat metabolism, support blood sugar regulation, and calm systemic inflammation. And best of all? Dr. Bart has real before-and-after lab results to prove it. In this episode: Why Berberine is being compared to Metformin—and often outperforms it The 5 powerful health benefits that make it Dr. Bart's go-to supplement How it impacts gut health, inflammation, fat storage, and insulin resistance Why lifestyle still matters—and how to pair Berberine with smart changes Real lab-backed results from patients in Dr. Bart's practice  

In dieser Woche geht's weiter mit unserem Thema Diabetes mellitus Typ 2. Wir steigen ein in einen besonders wichtigen Bereich – die Medikamentenlehre - Bestandteil der zweiten Therapiesäule. Und dabei kommst vor allem DU ins Spiel, denn hier brauchst du fundiertes Wissen. Wir starten mit den oralen Antidiabetika und schauen uns unter anderem Metformin, Sulfonylharnstoffe und die Glinide genauer an. Du lernst, wie sie wirken, wann sie eingesetzt werden und was du für die Prüfung unbedingt wissen musst. Dein Einstieg in die medikamentöse Therapie bei Diabetes mellitus Typ 2 beginnt genau jetzt!

Send us a message with this link, we would love to hear from you. Standard message rates may apply.Prediabetes affects over one-third of Americans, yet 80% don't know they have it. We break down what this silent condition means for your health and provide practical strategies to prevent progression to diabetes.• Prediabetes is defined as blood sugar that's elevated but not high enough to be diabetes• Risk factors include being over 45, overweight, family history of diabetes, and certain racial backgrounds• Prediabetes independently increases risk for heart disease, stroke, and kidney disease• Losing just 7% of body weight and exercising 150 minutes weekly reduces diabetes risk by 58%• Even without weight loss, exercise alone cuts diabetes risk by 44%• Focus on whole foods, legumes, fruits, vegetables, and limiting processed foods• Poor sleep significantly increases diabetes risk—aim for 7-8 hours of quality sleep• Metformin may be recommended for higher-risk individuals• Prediabetes is reversible with lifestyle changesFollow our podcast and share this episode with a loved one—since one-third of Americans have prediabetes and most don't know it, you could help someone take control of their health before it's too late.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

Become a patient: https://prevmedhealth.com/ +1 859 721 1414Take Control of Your Health: https://drfordbrewermd.com/Check out our New Supplements: https://drfordbrewermd.com/shop/Check out the AT HOME Metabolic Risk Assessment Kit: https://drfordbrewermd.com/metabolic-health-screening-kit/

In this episode, we're spotlighting a surprising superstar in the world of thyroid health—metformin. That's right—the go-to medication for type 2 diabetes is now making waves in the Hashimoto's and hypothyroidism communities. But why?We'll break down how metformin works to regulate your blood sugar and boost insulin sensitivity—and more intriguingly—how emerging research shows it may also help reduce autoimmune antibodies, support healthier thyroid hormone levels, improve gut health, and even aid with weight loss.Could metformin be a game-changer for your thyroid? You'll want to listen to this issue, and join us for this deep dive into the benefits, potential side effects, and what you must know before considering it as part of your treatment plan. Need more information? Learn more at the Paloma Health blog:Metformin, Hashimoto's, and Hypothyroidismhttps://www.palomahealth.com/learn/metformin-hashimotos-hypothyroidism Does Metformin Cause Weight Loss With Hypothyroidism?https://www.palomahealth.com/learn/hypothyroidism-weight-loss-metformin About Paloma Health:⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused exclusively on treating hypothyroidism. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. Become a Paloma Member:https://www.palomahealth.com/pricing-hypothyroidism Paloma Complete Thyroid Blood Test Kit:https://www.palomahealth.com/home-thyroid-blood-test-kit

Everyone wants to live longer and feel better, but the flood of information on supplements, drugs, and fitness can feel overwhelming.I invited Siim Land, an expert and 8-time bestselling author on longevity, to cut through the noise and share simple, evidence-based strategies that really move the needle when it comes to health and lifespan.Siim shares incredible, science-based tips on how we can enhance our healthspan and lifespan without getting lost in the hype.We dig into why exercise, especially combining strength training with cardio, is the single most powerful anti-aging tool. Siim explains how even small changes in daily activity can dramatically reduce your risk of chronic disease and help you live longer.We also talk about what everyone is curious about - Rapamycin, Metformin, Senolytics, and more - and I'm excited to share what the research really says about these popular longevity compounds. Siim also shares why having strong social relationships may be even more important than any pill.If you want clear, practical guidance on living healthier and longer, this episode is for you. Click play and join us for a deep dive into real, sustainable longevity strategies!Key Takeaways:Introduction (00:00)Siim Land's background and journey to longevity (00:30)Exercise is the top anti-aging intervention (05:31)Benefits of moderate daily activity (08:38)Importance of resistance training for muscle and metabolism (10:42)Cardiorespiratory fitness explained with heart rate zones (15:24)Thoughts on supplement overload and key supplements (26:19)Concerns about fish oil oxidation (29:06)Sunscreen vs antioxidants debate (35:53)Senolytics and longevity drugs overview (39:05)Metformin benefits (43:15)Calorie restriction and body composition for longevity (47:11)Social relationships are key to life satisfaction (50:18)Additional Resources: ✨ Connect with Siim LandBooks: https://www.amazon.com/stores/Siim-Land/author/B019H1Z14M?Instagram: https://www.instagram.com/siimland/?hl=enFacebook: https://www.facebook.com/thesiimlandYouTube: https://www.youtube.com/c/siimland—✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

I'm diving deep with Regan Archibald, an absolute peptide and regenerative medicine genius to unearth mind-blowing therapies that fight aging, melt fat, heal your body, and sometimes even help you skip surgery entirely. If you're tired, feeling older than your age, or frustrated that traditional protocols aren't moving the needle, you need to hear this. We break down why most people barely scratch the surface when it comes to peptides and why these little protein messengers are the secret to amplifying your results—think faster gut healing, squashing mold toxicity, supercharging immune resilience, and getting you vibrant again on a cellular level. From innovative gut-healing protocols to stacking the right peptides for real transformation, Reagan drops gems that will completely shift your expectations about how fast and radically you can upgrade your health. We also talk muscle preserving, fat-burning, body composition-boosting peptide stacks, and why Rapamycin and Metformin could be sabotaging your muscle building goals as you age. Think next level breakthroughs: exosomes, stem cells and the new world of plasma renewal therapy that's basically an oil change for your blood. Whether you're struggling with pain, aiming for a killer physique, or curious about brain optimization and the future of longevity medicine, this episode is packed with protocols, client stories and takeaways that just might blow your current health plan out of the water. Work with Regan Archibald and his Team https://acueastwest.com/ WHAT DO MY LABS MEAN?! Try the ultimate tool to Decode Your Labs: Understand your thyroid, hormones, and blood sugar numbers to transform your health https://dramie.com/labs/ We prescribe to all 50 states!  When you're ready to FINALLY get the help you deserve… Book a free application call: https://dramie.com/book-a-call/ Shop ALL of Dr. Amie's Fixxr® Supplements: https://betterlifedoctor.com/ EARN CE Credits: "Nurses, hold-on  – here comes the exciting part: you can earn nursing CE credits by listening to our podcasts! That's right—RNegade has teamed up with podcast hosts like me who are delivering amazing content that doesn't limit you to “thinking outside-the box,” it challenges you to BLOW-UP the box by learning from innovators, pioneers, and RENEGADES in the field of health and medicine WHILE EARNING YOUR CEs!” https://rnegade.thinkific.com/?ref=4d98d0 RATE, REVIEW AND FOLLOW ON APPLE PODCASTS If you made it this far I'm impressed! That means you really love the show and I love you for that!  So I'm going to ask you for a favor. Would you please leave a quick review or even 5⭐️. I DO read them and can't tell you how much I appreciate it! Thank you in advance!❤️  Just click here it's quick and easy : https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263,  Ok ONE MORE favor…would you please subscribe and follow the show? This is a win-win! It tells the podcast powers that be that you like The Thyroid Fixer Podcast AND it lets you catch all the new episodes that come out every week. Follow with this link: https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263 and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Want to get your labs reviewed and your questions answered LIVE by me? Join my exclusive Facebook group, Just Fix Your Thyroid – a supportive and empowering community designed to give you the tools, guidance, and HOPE you need on your thyroid and hormone journey.

In this solo episode of The Red Light Report, Dr. Mike explores the profound connection between mitochondrial health and oral disease. He reviews three recent studies highlighting how red light therapy, methylene blue, and compounds like urolithin A can support oral tissues, reduce inflammation, and even impact systemic conditions like diabetes and neurodegeneration. From root canal innovations to mitophagy in periodontitis, this episode is full of cutting-edge insights and practical applications for anyone interested in longevity, biohacking, or oral health optimization.Key Topics Covered:Study #1: Methylene Blue + Graphene Oxide for Root Canal Photodynamic Therapy• Combining methylene blue and reduced graphene oxide with red light therapy significantly improves antibacterial and antifungal effects in root canals.• Highlights the synergy between methylene blue and red light.• Dr. Mike shares how his nighttime routine—using BioBlue Calm and a red-light toothbrush—may create a low-level photodynamic therapy effect in the mouth.Study #2: Mitophagy in Periodontal Disease• Mitophagy (mitochondrial autophagy) plays a key role in managing inflammation, bone remodeling, and cell death in gum disease.• Key interventions to enhance oral mitophagy:• Urolithin A (strong Pink1/Parkin pathway activator)• Resveratrol, Melatonin (support mitochondrial quality)• Berberine, Curcumin, Metformin (via AMPK activation)• NR, Quercetin (via SIRT1 + PGC-1α pathway)Study #3: Mitochondrial Dysfunction Links Oral and Systemic Diseases• Periodontitis driven by mitochondrial dysfunction is linked to diseases like diabetes, cardiovascular disease, and neurodegeneration.• Key issues:• Impaired mitochondrial fusion/fission, biogenesis, and mitophagy.• Excessive ROS and mitochondrial DNA leakage fuel inflammation.• Poor mitochondrial function impairs periodontal stem cell regeneration.• Therapeutic approaches:• Antioxidants (CoQ10, resveratrol, melatonin, curcumin, EGCG)• Photodynamic therapy (methylene blue + red light)• Mitochondria-targeted compounds to modulate apoptosis and inflammation.Dr. Mike's Takeaways• Oral mitochondrial health is foundational—not isolated from systemic health.• Red light therapy and methylene blue offer powerful synergistic effects, even in oral applications.• A mitochondria-first approach may provide long-term protection against oral and systemic disease.   If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key points: 00:00 – Introduction: Mitochondrial Health & Podcast Focus 00:32 – Announcements: Health Alchemy Bundle & Upcoming Events 06:18 – Study 1: Methylene Blue & Red Light Therapy for Root Canal Treatment 08:42 – Methylene Blue Benefits Recap 13:37 – Study 1 Discussion: Photodynamic Therapy Enhancements 16:57 – Practical Application: Methylene Blue for Oral Health 19:40 – Study 2: Mitophagy in Periodontal Disease 23:46 – Targeted Mechanisms to Enhance Mitophagy 28:42 – Study 3: Mitochondrial Dysfunction in Periodontitis & Systemic Diseases 31:38 – Therapeutic Strategies for Mitochondrial Health 41:44 – Integrative Mitochondrial Therapies 47:02 – Conclusion: Mitochondrial Dysfunction as a Core Issue 50:45 – Closing Thoughts & Upcoming Events - Articles referenced in episode:Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatmentMitophagy and Its Significance in Periodontal DiseaseMitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies - Get over $6,000 worth of wellness education from top experts for $50! The Health Alchemy BundleThis is an amazing opportunity put together by Carrie Bennett and Sarah Kleiner! This Bundle is collection of 60+ eBooks, courses, and other resources available for $50 at a mind-blowing 99% discount.     This massive collection of resources is rooted in the science + spirituality of healing with nature, which cover topics like: Circadian & quantum biology Mental, emotional, & spiritual health Nutrition, minerals, & supplementation (when necessary) Herbalism & homeopathy Movement, posture, & fitness Hormonal health, pregnancy, & parenting And even specific issue support—from healing autoimmunity to improving sleep, & more This is a limited opportunity that goes through TOMORROW, May 23rd, so act now and don't miss out!   Get The Health Alchemy Bundle by clicking here! - Upcoming BioLight Events:   Biohacking Conference - May 28 - 30 (Austin, TX)   Returning to Nature (Quantum Health Retreat), June 26 - 27 (Franklin, TN) - Introducing the Newest BioBlue Supplement! The most comprehensive, powerful mitochondrial support supplement on the market ...   What is The Fountain of Youth in simple terms? An unparalleled supplement for brain power, energy, and longevity This supplement is like a high-performance tune-up for your brain and body. It combines powerful natural and science-backed ingredients to help you think clearer, feel more energized, and support your long-term health.The BioBundle automatically saves you 15% on both of the supplements you choose.   For the next two weeks, SAVE 20% on your order of BioBlue Fountain of Youth! Simply use code FOY20 Code expires 5/29, midnight PST   Click here to check out BioBlue Fountain of Youth - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

Joe Biden's advanced prostate cancer diagnosis I'm prediabetic, and my doctor wants to start me on Metformin. What are your thoughts? Is it a good idea to take metformin for its anti-aging benefits?

In this episode, Dr. Adam Rinde welcomes back microbiologist and PolyBio Research Foundation co-founder Dr. Amy Proal. Together, they unravel a framework for understanding chronic illnesses through the lens of persistent infections and their impact on mitochondria, immunity, and neurological health.Dr. Proal shares cutting-edge research linking pathogens like herpesviruses, cytomegalovirus, Epstein-Barr, and even latent parasites to conditions like Alzheimer's, long COVID, chronic fatigue syndrome, POTS, and more. Discover how stealth microbes can disrupt the vagus nerve, hijack mitochondrial energy systems, and weaken immune responses, setting the stage for a cascade of chronic dysfunctions.The conversation dives deep into the role of immune modulation, including promising findings around low-dose rapamycin and its potential to restore immune signaling and combat viral persistence. They also explore diet, metabolic interventions, and new clinical trials shaping the future of treatment.Whether you're a patient, practitioner, or curious mind, this episode offers profound insight into the evolving science of chronic illness and hope for emerging therapies.

Send us a textDr. Holly Thacker dives deep into the world of endocrinology and anti-aging with guest Dr. Elena Christofides. Dr. Christofides highlights how hormonal health significantly impacts women's well-being as they age. The discussion covers common health challenges women face, potential treatments, and the importance of personalized assessments to optimize health through lifestyle and pharmacological means. • Explanation of endocrinology and its roles in overall health • Common health concerns for midlife women • Importance of understanding aging vs. hormonal imbalance • Overview of Metformin and emerging treatments like rapamycin • The significance of mitochondrial health • Connection between environmental factors and health optimization • Empowerment through health advocacy and informed choices For more information on Dr. Elena Christofides, visit endocrinology-associates.com. You can listen to Dr. Christofides podcast on medcentral.com.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts SpotifySupport the show

The FiltrateJoel TopfAC GomezSophia AmbrusoNayan AroraSpecial Guest Charles Edelstein, MD, PhD Professor, Medicine-Renal Med Diseases/HypertensionExtra-Special GuestMichelle Rheault, MD Professor of Pediatrics, University of MinnesotaEditing bySimon and Joel TopfThe Kidney Connection written and performed by by Tim YauShow NotesKDIGO ADPKD Guidelines:WebsiteGuideline PDFExecutive Summary PDFNephJC coverageConsortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)Hy's Law (Wikipedia) has three components:ALT or AST by 3-fold or greater above the upper limit of normalAnd total serum bilirubin of greater than 2× the upper limit of normal, without findings of cholestasis (defined as serum alkaline phosphatase activity less than 2× the upper limit of normal)And no other reason can be found to explain the combination of increased aminotransferase and serum total bilirubin, such as viral hepatitis, alcohol abuse, ischemia, preexisting liver disease, or another drug capable of causing the observed injuryMeeting this definition yields a very high risk of fulminant kidney failure (76% in one series)Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database (PubMed) Two of 957 patients on tolvaptan met Hy's law criteria. None had fulminant kidney failure.Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial (PubMed) Patients had a baseline urine volume on tolvaptan of 6.9 L/24 h. Urine volume decreased to 5.1 L/24 h with hydrochlorothiazide and to 5.4 L/24 h on metformin.TEMPO 3:4 Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease (NEJM)Reprise Trial Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease ( NEJM | NephJC )Unified ultrasonographic diagnostic criteria for polycystic kidney disease by Edelstein in JASN (PubMed)Tolvaptan and Kidney Function Decline in Older Individuals With Autosomal Dominant Polycystic Kidney Disease: A Pooled Analysis of Randomized Clinical Trials and Observational Studies (PubMed)Charles' draft choice Recommendation 4.1.1.1: We recommend initiating tolvaptan treatment in adults with ADPKD with an estimated glomerular filtration rate (eGFR) ‡25 ml/min per 1.73 m2 who are at risk for rapidly progressive disease (1B).Sophia's draft choice Recommendation 1.4.2.1: We recommend employing the Mayo Imaging Classi cation (MIC) to predict future decline in kidney function and the timing of kidney failure (1B).Progression to kidney failure in ADPKD: the PROPKD score underestimates the risk assessed by the Mayo imaging classification (Frontiers of Science)AC's draft choice Recommendation 9.2.1: We recommend targeting BP to ≤ 50th percentile for age, sex, and height or ≤ 110/70 mm Hg in adolescents in the setting of ADPKD and high BP (1D).HALT-PKD Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease (NEJM)Nayan's draft choice Recommendation 6.1.2: We recommend screening for ICA in people with ADPKD and a personal history of SAH or a positive family history of ICA, SAH, or unexplained sudden death in those eligible for treatment and who have a reasonable life expectancy (1D).Screening for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease (CJASN)Surgical Clipping Versus Endovascular Coiling in the Management of Intracranial Aneurysms (PubMed) Clipping is associated with a higher rate of occlusion of the aneurysm and lower rates of residual and recurrent aneurysms, whereas coiling is associated with lower morbidity and mortality and a better postoperative course.Joel's editorial pick Recommendation 6.1.1: We recommend informing adults with ADPKD about the increased risk for intracranial aneurysms (ICAs) and subarachnoid hemorrhage (1C).Joel's first draft pick The bring out your dead pick:Recommendation 4.3.1: We recommend not using mammalian target of rapamycin (mTOR) inhibitors to slow kidney disease progression in people with ADPKD (1C).Recommendation 4.4.1: We suggest not using statins specfiically to slow kidney disease progression in people with ADPKD (2D).Recommendation 4.5.1: We recommend not using metformin specifically to slow the rate of disease progression in people with ADPKD who do not have diabetes (1B).Recommendation 4.6.1: We suggest that somatostatin analogues should not be prescribed for the sole purpose of decreasing eGFR decline in people with ADPKD (2B).Perfect match: mTOR inhibitors and tuberous sclerosis complex (Orphanet Journal of Rare Diseases)Navitor Pharmaceuticals Announces Janssen Has Acquired Anakuria Therapeutics, Inc. (BioSpace) This is press release about acquiring the mTor1 inhibitor.Joel's second draft pick Recommendation 4.2.1.1: We suggest adapting water intake, spread throughout the day, to achieve at least 2–3 liters of water intake per day in people with ADPKD and an eGFR ≥ 30 ml/min per 1.73 m2 without contraindications to excreting a solute load (2D).Nayan's bonus draft Practice Point 4.7.1: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) should not be used to slow eGFR decline in people with ADPKD.Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan (KIReports)SMART Trial of GLP-1ra in non-diabetics: Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial (PubMed)Tubular SecretionsNayan: Landman on Paramount Plus (IMDB)Sophia: PassNayan: steps in with The Pitt on HBO (Wikipedia)Charles: The White Lotus, Yellowstone 1923, Poirot (IMDB)AC: The PittMichael Crichton's Estate Sends The Pitt to the Courtroom (Vulture)Joel: I Must Betray you by Ruta Sepetys (Amazon)

Hva skjer når fastlegen selv får kreft – ikke én, men to typer samtidig – og nekter å godta at det ikke finnes noe han kan gjøre selv? I denne episoden møter du bokaktuelle Øyvind Torp, fastlege, forfatter og tidligere kreftpasient, som brukte både sin medisinske kunnskap og biohackingverktøy for å ta kontroll over egen helse. Diagnosene ble et vendepunkt – og starten på et dypdykk i alt fra kosthold og metabolisme til søvn, stress og cellenes energiomdanning.Øyvind er aktuell med boka Selvforsvar mot sykdom, hvor han deler kunnskapen han selv skulle hatt da livet sto på spill. Nå veileder han pasienter med et nytt blikk – med håp, ydmykhet og reseptfrie råd.Vi snakker om:Hvordan han oppdaget kreften , og fikk hele to typer– og hvorfor han mener tidlige, diffuse symptomer må tas på alvorHvorfor vi må tenke selvforsvar mot sykdom, og hva det betyr i praksisDe tre tause triggerne bak sykdom: Insulinresistens – og hvordan det starter mye tidligere enn du tror. Oksidativt stress – kroppens indre rust.Kronisk inflammasjon – betennelsen som aldri slukker.Hva er Warburg-effekten? Kreftceller bruker gjæring til energiproduksjon selv med oksygen til stede.og mitokondriesvikt som påvirker kreftutviklingKreftceller foretrekker sukker og bruker gjæring fremfor mitokondriell forbrenning, noe som fremmer rask vekst og undertrykker normal energiomdannelse.Hvilken betydning har Metformin, fasting og sukker – kan vi svekke kreftceller med livsstil?Hvorfor Torp mener vi må kombinere medisinsk behandling med aktiv egeninnsats – og hva han ville gjort annerledes i dagDu får også konkrete biohacking-grep:Hvordan styrke mitokondrieneHva mener Torp om ultraprosessert mat, søvn og stress knyttet til sykdomHvorfor relasjoner og mening kan være like viktig som mat og mosjonOg hvordan vi kan forstå helsesystemet som en lekk båt, og likevel stå stødig i vår egen helsehverdagDGled deg til en episode full av liv, kampvilje og kraft – så kan du bli bedre rustet, sterkere og mer bevisst på hva kroppen din faktisk prøver å fortelle deg.Du finner lege Øyvind Torp her: @torp_oyvindSelvforsvar mot sykdom:: https://www.ark.no/produkt/boker/hobbyboker-og-fritid/selvforsvar-mot-sykdomTakk til våre samarbeidspartnere:Flexbeam: www.recharge.health Instagram: https://www.instagram.com/theflexbeam/Rabattkode: BG10Oslo skinlab: Osloskinlab.no: rabattkode: bio60 @osloskinlabBok: BIOHACKING: https://www.ark.no/produkt/boker/hobbyboker-og-fritid/biohacking-9788205611474Nysgjerrig på neste Biohacking Weekend 22 og 23 mars 2026? Mail: christin@kongresspartner.no

In this episode, we explore the potential role of the probiotic Akkermansia muciniphila in managing olanzapine-induced weight gain. Could this tiny gut bacterium be the key to maintaining metabolic health while on antipsychotics? Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.5 CME: Quick Take Vol. 67 Olanzapine-Induced Weight Gain: Can Akkermansia Muciniphila Help?

Welcome to The Superhumanize Podcast.I'm your host, Ariane Sommer—and in this episode, we explore a frontier of health that's been quietly shaping our biology all along: the world of glycans.My guest is Nikolina Lauc, co-founder and CEO of GlycanAge—a pioneering biotech company using glycan biomarkers to measure biological age and predict long-term health outcomes. Her work is helping to shift the paradigm of aging from something we passively endure to something we can actively understand—and even influence.We dive into what glycans are—these complex sugar molecules that modify proteins and silently direct processes like inflammation, immunity, and aging.Nikolina explains how they reveal a layer of biological communication most of us have never heard of… and how listening to that hidden language can help us prevent disease years before it begins.We also explore GlycanAge's breakthrough menopause biomarker, their personalized approach to longevity, and what it means to raise awareness around women's health in a data-driven age.If you've ever wanted to go deeper than genetics—If you've sensed there's more to your body's story than your DNA—This episode may open a new door for you.Episode highlights:-What glycans are and why they matter more than genes alone-How chronic inflammation predicts disease up to 10 years in advance-The science behind GlycanAge's biological age test-Why exercise and diet affect everyone differently-The coming revolution in menopause diagnostics-Metformin, biohacking, and the myth of one-size-fits-all longevity-The future of personalized health data and ethical enhancementResources mentioned:Glycan Age https://glycanage.com/Guest's social handles:Nikolina LaucLinkedIn https://www.linkedin.com/in/nikolinalaucInstagram https://www.instagram.com/nikolinalauc/Glycan AgeInstagram https://www.instagram.com/glycanage/X https://x.com/glycanageFacebook https://www.facebook.com/glycanage/YouTube https://www.youtube.com/channel/UCn1OeXYKa-NmKr9AtczwN4Q

1. High-intensity interval training (HIIT)Just a few minutes of high-intensity exercise with lots of rest can quickly deplete excess sugar in your blood. Try doing exercises such as burpees, plyometrics, or a spin bike.2. Apple cider vinegarApple cider vinegar contains acetic acid, which can slow down a blood sugar spike after consuming sugar. Combine one tablespoon of apple cider vinegar with 8 ounces of water and drink this after a high-carb meal. 3. Berberine, NAC, and other supplementsBerberine is considered a natural Metformin without the side effects. You can pair berberine with NAC or alpha lipoic acid for more natural blood sugar support. Excess carbs deplete vitamin B1, so if you have a cheat meal or fall off the wagon with carbohydrates, increase vitamin B1.4. Post-meal walkA 25 to 30-minute post-meal walk can help burn off excess sugar so that it is not converted into cholesterol or stored as fat. 5. Potassium and magnesiumPotassium is necessary for glucose storage in the liver and the muscles. It also helps move glucose into your cells. Magnesium is critical for the cells that produce insulin. Nearly every diabetic is deficient in magnesium!6. Ketone supplements Providing the brain with ketones supports healthy blood sugar in the brain, which can improve cognitive function and decrease brain fog. 7. Saltwater Sodium helps prevent stress-induced blood sugar spikes. Adding more salt to your last meal or adding it to a glass of water can improve sleep and calm your mood.Dry fasting can lower blood sugar faster than anything else! Dry fasting means you're not drinking water or eating food. When you're dry fasting, your body increases the hormone glucagon, which helps to lower blood sugar. Growth hormone and antioxidants also increase, and your body quickly switches to fat-burning.Dr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media.

Dr. Hoffman continues his conversation with Dr. Jacob Teitelbaum, Integrative Medicine physician, researcher, and best-selling author.

Diabetes Deep Dive: Dr. Jacob Teitelbaum, an integrative medicine physician and author, discusses diabetes from a multifaceted perspective. They explore the connections between diabetes, chronic fatigue syndrome, fibromyalgia, sleep disorders, metabolic syndrome, and long COVID. Dr. Teitelbaum offers insights into the historical emergence of diabetes in correlation with lifestyle and dietary changes, particularly the Western diet's high sugar and low fiber content. They discuss the roles of vitamin D, magnesium, and other nutrients, as well as the impact of chemicals on metabolism. The conversation also covers the importance of sleep, stress management, and lifestyle adjustments. Dr. Teitelbaum recommends natural supplements like Sucontral D, berberine, and melatonin to manage blood sugar levels effectively. The episode concludes with a discussion on the controversial role of pharmaceutical interventions like GLP-1 drugs and insulin. Dr. Teitelbaum emphasizes a balanced, integrative approach that empowers self-care and holistic health management.

In this episode of The Living to 100 Club Podcast, we welcome back the dynamic and insightful Lynne Bowman. Now celebrating her 80th year, Lynne shares reflections on embracing aging, health trends, and personal reinvention. We discuss her fitness journey, the evolving views on sugar substitutes and healthy eating, and the role of social connection in longevity. We also touch on embracing new passions—whether it's painting, drumming, or exploring AI technology. This conversation is an inspiring reminder that aging is not about slowing down but about evolving, learning, and thriving. Key Takeaways: A New Perspective on Aging: Lynne reflects on turning 80 and how aging brings freedom from societal expectations. Health Trends & Longevity: Insights on sugar substitutes, the Keto and carnivore diets, and the potential longevity benefits of Metformin. The Power of Social Connection: How community and shared meals enhance well-being, especially for those living alone. Reinvention & Lifelong Learning: Joe and Lynne discuss personal growth, staying mentally and physically active, and embracing new hobbies like drumming and painting. AI in Podcasting & Content Creation: Exploring the role of AI in summarizing conversations and content generation. Mini Bio Lynne has been featured at women's expos throughout the country, teaming with actress Deidre Hall to write and publish Deidre Hall's Kitchen Closeup (2010) and Deidre Hall's How Does She Do It? (2012). In previous lives, she won national awards as a creative director for Silicon Valley companies, was Creative Director at E&J Gallo Winery, Advertising Manager at RedKen Laboratories, and freelanced for agencies in San Jose, Los Angeles, and New York. She has also worked as an actress, makeup artist, screenwriter, illustrator, legal journalist, and television Weather Person. Lynne has three grown children, two absolutely perfect grandchildren, and is president of The Pescadero Foundation. She and her husband have a small farm on the coast of Northern California. For Our Listeners Lynne's website: LynneBowman.com Lynne's book: Brownies for Breakfast

Episode 189: Intermittent Fasting (Religious and Sports)Future Doctors Carlisle and Kim give recommendations about patients who are fasting for religious reasons, such as Ramadan. They also explain the benefits and risks of fasting for athletes and also debunked some myths about fasting. Dr. Arreaza add input about the side effects of fasting and ways to address them.    Written by Cameron Carlisle, MSIV (RUSM) and Kyung Kim, MSIV (AUC). Editing by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Introduction: In the last episode on fasting (#179), we explored how intermittent fasting (IF) can help manage type 2 diabetes by improving insulin sensitivity, promoting weight loss, and lowering inflammation. We discussed the benefits of methods like 16:8 time-restricted eating and the 5:2 meal plan, and even compared IF to medications like metformin. Today, we're bringing that science into real life. We'll talk about how people fast for religious reasons, like during Ramadan, how athletes use IF to stay in shape, and how we can use IF as a tool in family medicine to support community health and A1c control.Intermittent Fasting in Religious PracticeRamadan just ended on 3/30/25, but this is a great time to talk about the broader role of fasting in religion and health. Many faiths incorporate fasting into spiritual practice and understanding this can help us better support our patients.Islam (Ramadan): Ramadan is a month where Muslims fast from dawn to sunset, focusing on spiritual reflection and self-control. No food or drink is consumed during daylight hours. Despite this, studies have shown that with good planning, fasting during Ramadan does not significantly impair physical performance or metabolic health.Key health tips for patients observing Ramadan:Hydrate well between iftar (sunset) and suhoor (pre-dawn).Break the fast with dates and water to gently replenish energy and electrolytes.Eat balanced meals with complex carbs, protein, and healthy fatsAvoid greasy, heavy foods right after fastingLight exercise (such as a walk) after iftar is beneficialReview medications with a healthcare provider, especially for those on insulin or sulfonylureas.For example: Metformin should be taken when you break your fast and then again before dawn. If its an extended-release metformin, take it at night. Metformin does not cause significant hypoglycemia and can be continued during Ramadan. Basal insulin is advised to be given at Iftar, and the dose should be reduced by 25-35% if the patient is not well managed. And regarding the fast-acting insulin, it requires a little more reading, so you can look it up and learn about it. Judaism: In Judaism, fasting is practiced on days like Yom Kippur and Tisha B'Av, typically lasting 25 hours without food or water. These fasts are spiritual and reflective, and patients with medical conditions may seek guidance on how to participate safely.Christianity: Many Christians fast during Lent, either by abstaining from certain foods or limiting meal frequency. Some practice partial-day fasts or water-only fasts for spiritual renewal.A branch of Christianity known as The Church of Jesus Christ of Latter-day Saintsoften observe a 24-hour fast on the first Sunday of each month, known as Fast Sunday, where they abstain from food and drink and donate the cost of meals to charity. This practice is both spiritual and communal.Cameron: Fasting for religious reasons, when done safely, can align with IF protocols and be culturally sensitive for diverse patients in family medicine.IF in Athletes and PerformanceIntermittent fasting is gaining popularity in the sports world. Athletes are using IF to improve body composition, increase fat oxidation, and enhance metabolic flexibility. A recent study, known as the DRIFT trial and published in Annals of Internal Medicine, found that fasting three non-consecutive days a week led to more weight loss than daily calorie restriction. Participants lost an average of 6.37 pounds more over 12 months.Why? Better adherence. People found the 3-day fasting schedule easier to stick to than counting calories every day.Benefits of IF for athletes:Encourages fat burning (via AMPK activation and GLUT4 upregulation, listen to ep. 179).Helps maintain lean muscle while reducing fat.No major drop in performance when meals and workouts are timed properly.What are some practical tips?Schedule workouts during or just before eating windows.Eat protein-rich meals post-workout.Avoid intense training during long fasts unless adapted.Stay hydrated, especially in hot environments or endurance sports.Broader Applications and Myths Around IFHormonal Effects of IF: In addition to improving insulin sensitivity, IF also affects hormones such as ghrelin (which stimulates hunger, remember it as growling) and leptin (which signals fullness). Over time, IF may help the body regulate appetite better and reduce cravings. IF can also decrease morning cortisol levels, the stress hormone. That's why it's important to monitor sleep, hydration, and stress levels when recommending IF.Circadian Rhythm Alignment: Emerging research shows that aligning eating times with natural light/dark cycles—eating during the day and fasting at night—can improve metabolic outcomes. This practice, known as early time-restricted eating (eTRE), has been shown to lower blood glucose, reduce insulin levels, and improve energy use. Patients who eat earlier in the day tend to have better results than those who eat late at night.Myths and Clarifications on IF:-“Fasting slows metabolism” In fact, short-term fasting may boost metabolism slightly due to increased norepinephrine. -“You can't exercise while fasting.” Many people can safely train during fasted states, especially for moderate cardio or strength training. -“Skipping breakfast is bad.” For some, skipping breakfast is a useful IF strategy—as long as total nutrition is maintained. You can break your fast at 2:00 pm, it does have to be at 7:00 AM.What to Eat When Breaking a FastBreaking a fast properly is just as important as fasting itself. Whether it's after a Ramadan fast or a 16-hour fast, the goal is to replenish energy gently and restore nutrients.Ideal foods to break a fast:Dates and water: provide quick energy, potassium, and fiberSoups: lentil or broth-based soups are gentle on digestionComplex carbs: whole grains like brown rice or oatsLean proteins: chicken, fish, eggs, legumesFruits and vegetables: hydrate and provide fiberHealthy fats: nuts, avocado, olive oilProbiotics: yogurt or kefir for gut supportBalanced meals with carbs, protein, and healthy fats help the body transition smoothly back to a fed state.Using IF in Family Medicine and Community HealthIntermittent fasting can be a practical, cost-effective strategy in family medicine. In areas with high rates of obesity and diabetes, like Kern County, IF offers a lifestyle-based tool to improve metabolic health, especially in underserved populations. IF is free!How IF can help in family medicine:Lower A1c levels: improves insulin sensitivity and glucose controlPromote weight loss: decreases insulin resistance and inflammationReduce medication dependence: fewer meds needed over time for some patientsEncourage patient engagement: flexible and easier to follow than strict calorie countingFit diverse lifestyles: aligns with religious and cultural practicesAddress food insecurity: structured eating windows can help patients stretch limited food resourcesHow to apply IF in clinic:Start the conversation by asking if the patient has heard of IFRecommend simple starting points: 12:12 or 14:10Emphasize hydration and nutrient-dense mealsMonitor labs and symptoms, especially in diabetic patientsAdjust medications to avoid hypoglycemiaProvide follow-up and patient education handouts if possibleWhat if a patient isn't ready to try fasting?For those not ready to commit to intermittent fasting, one effective alternative is walking after meals. A simple 10–20 minute walk post-meal can help stimulate GLUT4 receptors in skeletal muscle, promoting glucose uptake independent of insulin. This reduces the demand on pancreatic beta cells and may help improve blood sugar control over time. This strategy is particularly useful for patients with insulin resistance or early-stage type 2 diabetes.Conclusion: Intermittent fasting is not one-size-fits-all, but it can be a powerful tool for both individual and community health. From Ramadan to race day, IF has a place in family medicine when used thoughtfully. Encourage patients to work with their healthcare providers to find an approach that fits their lifestyle, medical needs, and personal values. IF is a cost-effective toolEven without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:American Academy of Family Physicians. (2022). "Intermittent Fasting: A Promising Treatment for Diabetes." AAFP Community Blog. https://www.aafp.org/pubs/afp/afp-community-blog/entry/intermittent-fasting-a-promising-treatment-for-diabetes.htmlHealthline. (2023). "What Breaks a Fast? Foods, Drinks, and Supplements." https://www.healthline.com/nutrition/what-breaks-a-fast.Sarri KO, Tzanakis NE, Linardakis MK, Mamalakis GD, Kafatos AG. Effects of Greek Orthodox Christian Church fasting on serum lipids and obesity. BMC Public Health. 2003 May 16;3:16. doi: 10.1186/1471-2458-3-16. PMID: 12753698; PMCID: PMC156653. https://pmc.ncbi.nlm.nih.gov/articles/PMC156653/.Shang, Y., et al. (2024). "Effects of Intermittent Fasting on Obesity-Related Health Outcomes: An Umbrella Review." eClinicalMedicine.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00098-1.Abaïdia AE, Daab W, Bouzid MA. Effects of Ramadan Fasting on Physical Performance: A Systematic Review with Meta-analysis. Sports Med. 2020 May;50(5):1009-1026. doi: 10.1007/s40279-020-01257-0. PMID: 31960369. https://pubmed.ncbi.nlm.nih.gov/31960369/.Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

Cyrus Khambatta reveals how a plant-based diet can reverse prediabetes and type 2 diabetes. Learn the science and practical steps to take control of your health. #ReverseDiabetes #PlantBasedDiet #HealthyLiving

Today, we're going to talk about the best drinks for diabetes management and prevention to support healthy blood sugar as you sleep. These 7 drinks help improve sleep quality by preventing troublesome issues like night waking and nighttime urination.Blood sugar often decreases at night, increasing cortisol, which increases blood sugar levels. Poor sleep can also cause blood sugar issues, and frequent urination at night can contribute to this problem.Here are 7 nighttime drinks to help stabilize blood sugar levels throughout the night. Try these drinks to support healthy blood sugar levels and improve sleep. 1. Apple cider vinegar with cinnamonAdd one to two tablespoons of apple cider vinegar with a pinch of cinnamon to a glass of water for the perfect blood sugar-balancing drink.2. Chamomile teaChamomile tea lowers cortisol and stabilizes blood sugar by directly supporting the cells in the pancreas.3. Golden milkCombine turmeric and ginger with milk to make a delicious blood sugar-balancing latte. 4. Aloe vera juiceAloe vera is known to help with digestion and ulcers and can be applied topically to wounds, but it also potently affects the cells that make insulin.5. Berberine teaThis herb is close in effectiveness to Metformin, just without the side effects!6. Electrolyte drinks (without sugar)Potassium and magnesium are vital for healthy blood sugar levels. Magnesium can significantly decrease cortisol, while potassium can reduce blood sugar and is essential for glucose storage in the liver and the muscles. Most people are not getting enough potassium!7. Salt in waterSodium is an important electrolyte that helps reduce blood sugar and cortisol. Add it to water or your electrolyte drinks to help increase hydration. It also supports the adrenal glands, nerves, and muscles. Dr. Eric Berg DC Bio:Dr. Berg, age 59, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media.

Welcome back! Today we will be discussing Metformin and some of the recent guidelines published in the journal the Schizophrenia Bulletin. (Carolan et. al 2024).

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Story at-a-glance A study that analyzed 52,501 Type 2 diabetes patients found widespread nutrient deficiencies, with vitamin D being most common (60.45%), followed by magnesium (41.95%) and vitamin B12 (28.72%) Vitamin D deficiency significantly impairs insulin function and sensitivity, while increasing the risk of complications like diabetic retinopathy, kidney disease and foot ulcers Magnesium deficiency creates a vicious cycle among diabetics — low intake increases diabetes risk, while diabetes increases magnesium loss through urination, leading to poorer glycemic control Metformin, the most prescribed diabetes medication, depletes vitamin B12 levels by interfering with B12 absorption, which can lead to nerve damage, numbness and fatigue Geographic location influences deficiency rates, with the Americas showing the highest prevalence at 54.04% of diabetes patients having at least one micronutrient deficiency

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog Do you ache all over? Are you weaker every year? Shorter and more bent over?   Are your clothes hanging off your shoulders? Do you walk slower and hold on to things as you walk? If you notice these signs in yourself or someone you love it means you, or they are becoming frail. As a physician I had to become a people watcher…. or more accurately an observer of the people around me.  Even if you aren't medical people, I am sure many of you are as well…. but being very observant is a requirement for a physician because there are many signs of illness that can be observed just from observing a patient who we I am treating.  I always pay attention to how the patient I am consulting with walks, shakes my hand (their strength), and how well they care for themselves, the quality of their speech, whether they look well nourished, over-nourished or frail.  All of these individual observations and more, become automatic to me as a doctor. They help me diagnose and treat my patients without a stethoscope or even an x-ray… Today I want to talk about frailty, what it is, and what it means to your doctor and you as a patient. Frailty can be defined as the visible qualities of loss of muscle mass, bone mass, energy, as and strength, as well as thinning of the skin, kyphosis of the spine (standing with your head looking down and your shoulders rounded), slow movements, weakness of strength and voice.  Frailty is the visible sign of aging. The opposite of Frailty is the Quality of being robust. When we are young we are strong, energetic, our muscles are visible, our skin is clear and taught, our posture is straight and we appear healthy and strong….when we are young we are Robust!   Frailty is the quality of being old and weak, in a catabolic state (or a state of tissue breakdown and “shrinking”).  You can equate Frailty with aging, or physically being old. What does frailty mean to a doctor? When we take care of a patient who comes to us for the first time in a frail state we rule in or out a list of diseases of aging and physical problems. These include: Arthritis Osteoporosis Sarcopenia or severe loss of muscle mass and strength Inflammatory diseases like arthritis Heart disease Diabetes Dementia Inability to be independent Doctors must look for illness and decide on a treatment to remedy a disease, but frailty is not considered a disease that has a treatment.  It is a sign that a patient is going through the last stage of life.  Many studies have been done that equate frailty to a limited life span and a loss of quality of life, but no treatment has been employed by mainstream medicine to delay, avoid or treat frailty. Up to now this is all very depressing, however it is my well founded belief that the loss of testosterone  after age 45 in women and 55 in men is the first step toward frailty, however if  adequate testosterone is replaced soon after the symptoms of T deficiency starts, then frailty can be avoided as we age, and the eventuality of loss of quality of life will be delayed or avoided all together.  It is a fact that nothing other than the hormone testosterone can reverse frailty and stop it from progressing. With T treatment my patients increase their muscle mass, create stronger muscles, and improved their mental and physical stamina. To me this is such an easy one-hormone-answer to actually improve my patients lives, at any stage in the aging process, however the pharmaceutical companies that control American medicine much prefer to treat each symptom with a different drug.  There are millions of aging folks in nursing homes who could have maintained their independence, and avoided the use of many drugs if they were treated with testosterone before their frailty reduced their mobility so they need help to perform daily activities of living independently. Sadly, medicine in the US basically gives up on frail and aging patients and we doctors are taught to make frail patients “comfortable”, just treating their symptoms without hope of reversing frailty and the outcomes of that condition.  Of course, it is much healthier to prevent frailty by replacing the essential hormone testosterone early on, however your doctor will have to think out of the box to arrive at the Testosterone treatment, rather than follow the medical protocols that involve just keeping aging patients “comfortable”. Research studies and articles to be read by doctors like the recent one in the New England Journal of Medicine that draws a direct line between aging and frailty, but only concentrates on the fact that frailty portends early death and discussed the best ways to make patients comfortable dictated by the severity of frailty.  There is no treatment other than high protein diet and vitamins with physical therapy which will not “treat” this disease. I want to tell you about two very different patients in my practice.  The first is a very successful man in his late 70s who came to me seeking weight loss because he had been an athlete and still enjoyed playing golf, but he was complaining of weakness and other symptoms of frailty, in addition to looking borderline frail when he first came to me.  We did a body composition test, and he had a higher fat mass and a lower that ideal muscle mass which is the way frailty begins. We discussed the fact that weight loss (fat loss) obtained by more exercise and less carbohydrate in his diet might improve his Pre-diabetes and inflammation, but would not make him stronger, or increase his physical and mental stamina, in other words reverse his beginning frailty.  He chose to embark on an exercise-based weight loss program combined with a high protein low carb diet. In the end he did not take my advice about the best way to lose weight without losing muscle which would have been to add Testosterone and Metformin to his treatment plan, however he wanted to be the one directing his own care (he was a business man and not a doctor) without a basic knowledge of physiology, or  nutrition, or any training about aging and frailty. Let me note that if he was younger than 55, and he tried this weight loss program while he was making adequate Testosterone, he might have had a successful fat loss program and gained muscle density and strength while he lost fat, however, this gentleman is 78. You can guess the end of the story.  He did lose weight, however he lost as much muscle as fat and was even weaker after 6 months.  This is sometimes what happens when very successful people in one area of life think that makes them brilliant in all disciplines. Now, the flipside of the coin.  I will tell you about an 82-year-old doctor who came to me almost too late.  His much younger wife was already my patient, and she encouraged him to have a consult with me to see what I could do for him.  He had the right attitude, but was already frail, and I could feel the humorous bone of his arm, when I ushered his into my office for his consultation.  I explained what observing him and his lab told me more while he told me that he had almost every symptom of aging, and frailty.  He told me that he was an athlete in college and that he always had a lot of muscle, and he watched every day as his muscles “melted away”, despite his exercise daily.  He was frustrated and had trouble with his memory as well because he had lost his testosterone long ago and he had done well for as long as he had because he had eaten a nutritious diet, taken supplements and worked out daily. We discussed his other medical problems, and some treatments for them, additional supplements to assist in building muscle and bone strength. He came back 5 months later after he had his T pellets inserted and he walked in with confidence, and the difference in his muscle mass was visible!  He was no longer “frail looking”.  He told me he was thinking better, not completely yet, but his mind was getting progressively better.  He had lost fat and gained muscle. He had turned the clock back 15 or more years.  Testosterone in the right dose and delivery system can erase frailty and give a quality of life back to my patients who had no help from other doctors. Look around you if you aren't yet at the age that carries with it frailty  or if you are without Testosterone and are experiencing frailty…look at those around you in the doctor's office or when you are waiting to board a plane…look at the pre-borders who can't walk the length of the ramp to the airplane and see if they have the visible characteristics I am talking about.   If you are over 45 and female or 55 and male and not on Testosterone maybe you should consider having your testosterone replaced so you can keep your muscle mass and independence as long as you live.

In this Huberman Lab Essentials episode, I explore how the nervous system impacts fat loss and how certain behaviors and supplements can accelerate fat burning. I explain how non-exercise movements like fidgeting and shivering trigger adrenaline to boost fat metabolism. I also examine the impact of exercise intensity and fasted workouts on fat burning, and how supplements such as caffeine, GLP-1 and berberine can further support fat loss. These science-based tools go beyond traditional calorie counting to enhance metabolism and improve body composition. Huberman Lab Essentials are short episodes (approximately 30 minutes) focused on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, and our full-length episodes will still be released every Monday. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Huberman Lab Essentials; Fat Loss 00:01:00 Calories In, Calories Out; Nervous System 00:02:57 Fat Burning, Nervous System & Adrenaline 00:06:31 Sponsor: David 00:07:45 Increase Adrenaline, Shivering, Tool: Fidgeting 00:11:25 Shivering & Fat Loss, White & Brown Fat 00:14:42 Tool: Deliberate Cold Exposure Protocol 00:16:43 Sponsor: AG1 00:18:38 High, Medium vs Low-Intensity Exercise, Exercise Fasted? 00:24:30 Tool: Exercise for Fat Loss; Adrenaline 00:27:18 Sponsor: LMNT 00:28:34 Caffeine, Dose, Exercise & Fat Loss 00:30:17 GLP-1, Yerba Mate, Exercise; Semaglutide 00:33:16 Berberine, Metformin, Insulin 00:34:12 Diet, Adherence, Carbohydrates & Insulin 00:35:52 Recap & Key Takeaways Disclaimer & Disclosures

Metabolic syndrome (MetSyn) is a cluster of conditions, such as increase in waist circumference, dyslipidemia (elevated triglyceride levels and reduced HDL), increased blood pressure, and increased fasting blood sugar levels that is related to insulin resistance, diabetes, and elevated risk of cardiovascular disease. Women with PCOS have a significantly higher prevalence of metabolic syndrome (MetS) compared to the general population, with studies indicating a prevalence of around 43-47% in PCOS women. PLUS, there is a high prevalence of moderate to severe depressive symptoms and depression in adults and adolescents with PCOS; therefore, screening for depression in all adults and adolescents with PCOS is encouraged. In this episode, we will review a new publication for the J Clinical Endo & Metabolism discussing this combination (PCOS and depression/anxiety) and the MetSyn, and we will review the EXPANDED indications for metformin for metabolic syndrome prevention/treatment according to the 2023 PCOS updated guidance.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

In this episode of Ask! Dr Chris answers questions including: what are the minerals in mineral water? Is it safe to drink water from plastic bottles? Is glass safe to drink from? How do people perform sword swallowing? What are biodegradable plastics made of? What is metformin, and is it effective? Like this podcast? Please help us by supporting the Naked Scientists

In this episode of Ask! Dr Chris answers questions including: what are the minerals in mineral water? Is it safe to drink water from plastic bottles? Is glass safe to drink from? How do people perform sword swallowing? What are biodegradable plastics made of? What is metformin, and is it effective? Like this podcast? Please help us by supporting the Naked Scientists

Silke is writing all the way from French Polynesia, asking what's best to do with all the plastic rubbish she picks up from the beach, and whether burning it is advisable. James Tytko asked Richard Lampitt from the National Oceanography Centre to help find an answer... Like this podcast? Please help us by supporting the Naked Scientists

In this episode of Shift with CJ, CJ chats with Siim Land, a leading voice in biohacking, bestselling author, and longevity expert. Siim shares his insights on fat loss, exercise, sleep optimization, and strategies to extend both healthspan and lifespan.Key TakeawaysFat Loss is About Caloric Deficit:Regardless of diet type, weight loss is driven by consuming fewer calories than you burn.High-protein, whole-food diets help with satiety and muscle maintenance.Berberine vs. Metformin:Berberine aids weight loss and blood sugar control but isn't as strong as metformin.Metformin shows promise for longevity, but only if you have metabolic dysfunction.Better Sleep Equals Better Health:Eat at least 4-5 hours before bed for optimal rest.Block blue light, lower room temperature, and use melatonin (4mg, 3 hours before bed).Exercise Smarter, Not Harder:900 minutes/week of moderate-intensity movement (walking, cycling, hiking) is optimal.High-intensity workouts should stay under 250 minutes/week to avoid overtraining.Build Reserves for Longevity:Physical: Maintain muscle and bone density.Cognitive: Keep learning to delay cognitive decline.Social: Strong relationships contribute to longer life.5 Things You Can Do TodayEat more protein and whole foods for sustained energy.Stop eating 4-5 hours before bed for deeper sleep.Get at least 8,000 steps daily—16,000 gives added benefits.Track blood markers (glucose, lipids, inflammation) and adjust accordingly.Don't stress over longevity hacks—balance matters!Where to Find Siim LandWebsite: Siimland.coYouTube & Instagram: @SiimLandBook: The Longevity Leap (available on Amazon

On this episode of Longevity by Design, Dr. Gil Blander speaks with Dr. Michael Ringel, COO of Life Biosciences, about the science of aging and longevity. Michael discusses how evolution influences lifespan and why aging occurs. He explains the trade-off between resource allocation for reproduction versus maintenance and repair within the body. Caloric restriction and its effects on lifespan are explored through an evolutionary lens.Michael highlights the challenges and breakthroughs in longevity research. He touches upon the role of genetics and pharmaceuticals in manipulating lifespan and healthspan. He points to the Pacific rockfish as an example of varying lifespans within a closely related group of species, demonstrating the genetic component of aging. He also notes the impact of Cell reprogramming, referencing a study on how specific Cell reprogramming can regenerate optic nerves.The conversation shifts to the business of longevity, where Michael discusses the increased interest and investments from big pharma and billionaires. He examines the economic benefits of extending healthspan, citing a potential value of $300 trillion from a 10-year healthspan extension in the US alone. Michael and Gil also explore the importance of lifestyle choices for healthy aging, emphasizing diet, exercise, sleep, stress management, and social connections.Guest-at-a-Glance

In this Huberman Lab Essentials episode, I explain how hormones regulate hunger, appetite and feelings of satiety (fullness), along with strategies to help control appetite. I describe how the body senses nutrient levels and how the brain processes these signals to stimulate hunger or suppress appetite. I also discuss how certain foods can help curb hunger, while processed foods and emulsifiers can interfere with satiety signals, leading to overeating. Additionally, I cover how lifestyle factors such as exercise and meal timing regulate blood glucose levels, which in turn impact hunger and appetite. Huberman Lab Essentials episodes are approximately 30 minutes long and focus on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, while our full-length episodes will continue to be released every Monday. This Huberman Lab Essentials is from the full-length Huberman Lab episode, “How Our Hormones Control Our Hunger, Eating & Satiety.” Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David Protein: https://davidprotein.com/huberman Mateina: https://drinkmateina.com/huberman LMNT: https://drinklmnt.com/huberman For all Huberman Lab sponsors, visit hubermanlab.com/sponsors. Timestamps 00:00:00 Huberman Lab Essentials; Hunger & Appetite 00:00:56 Hunger, Hypothalamus, Cortex & Mouth 00:04:46 Sponsor: David Protein 00:06:02 Melanocyte-Stimulating Hormone, AgRP Neurons, Ghrelin, Tool: Regular Meal Timing 00:10:13 Cholecystokinin (CCK), Tool: Omega-3s, Amino Acids & Blunting Appetite 00:13:26 Sponsor: AG1 00:14:30 Highly-Processed Foods, Emulsifiers, Tool: Whole Foods & Satiety Signals 00:19:10 Insulin, Glucose, Type 1 & 2 Diabetes 00:22:16 Sponsor: Mateina 00:23:41 Insulin & Glucagon, Tools: Food Order, Movement & Blood Glucose 00:27:26 Tool: Exercise & Stable Blood Sugar 00:29:38 Metformin, Ketogenic Diet, Blood Glucose 00:31:59 Sponsor: LMNT 00:33:16 Diabetes, Urine & Blood Sugar 00:35:40 Caffeine, Tool: Yerba Mate, Glucagon-Like Peptide -1 (GLP-1), Appetite 00:38:49 Recap & Key Takeaways Disclaimer & Disclosures

Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating. What You'll Learn: • The optimal fasting window for maximizing lifespan (Hint: It's not 16 hours) • The four fasting metabolites that extend life by 96% • How Mimio mimics fasting benefits—without giving up food • The real reason over-fasting destroys your metabolism and hormones • Why traditional longevity drugs (Metformin, Rapamycin) fall short • Can you build muscle and burn fat at the same time? The science of mTOR & AMPK • Why Big Pharma doesn't want you to know about this breakthrough *** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE *** Sponsors:Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mimio Instagram: https://www.instagram.com/mimiohealth/ • Mimio Website: https://mimiohealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:58 – Fasting & Longevity • 01:88 – Optimal Fasting Length • 03:39 – Alternate Day Fasting: Pros & Cons • 05:50 – Key Fasting Compounds • 07:34 – Spermidine & Longevity Molecules • 11:41 – FDA Roadblocks on Natural Compounds • 15:37 – AI, Big Data & Longevity Research • 31:19 – Mimio's Impact on Testosterone & Aging • 35:16 – Longevity & Death Philosophy • 36:48 – Biohacking Origins • 37:03 – Metabolism & Cognitive Function • 38:35 – Unexpected Effects of Fasting • 40:43 – Fasting & Circadian Rhythms • 43:09 – Mimio Science & Benefits • 45:14 – Mimio in a Daily Routine • 55:05 – Men vs. Women: Fasting Differences • 01:02:23 – Future of Nutrition & Biohacking • 01:07:21 – Conclusion & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Ralph DeFronzo is a distinguished diabetes researcher and clinician whose groundbreaking work on insulin resistance has reshaped the understanding and treatment of type 2 diabetes. In this episode, Ralph shares insights from his five decades of research, including his pivotal role in bringing metformin to the U.S. and developing SGLT2 inhibitors. Ralph explores the impacts of insulin resistance on specific organs, the pharmacologic interventions available, and the gold-standard euglycemic clamp method for measuring insulin resistance. This episode is a masterclass in the pathophysiology and treatment of type 2 diabetes, featuring an in-depth discussion of GLP-1 receptor agonists, metformin, and a lesser-known class of drugs that opened Peter's eyes to new possibilities in diabetes care. We discuss: Metabolic disease as a foundational driver of chronic illness [4:00]; Defining insulin resistance: effects on glucose, fat, and protein metabolism, and how it varies between healthy, obese, and diabetic individuals [8:15]; The historical significance of the development of the euglycemic clamp technique for measuring insulin resistance [11:45]; How insulin affects different tissues: liver, muscle, and fat cells [15:00]; The different ways insulin resistance manifests in various tissues: Alzheimer's disease, cardiovascular disease, and more [25:00]; The dangers of hyperinsulinemia, and the importance of keeping insulin levels within a physiological range [29:00]; The challenges of identifying the genetic basis of insulin resistance and type 2 diabetes [37:00]; The “ominous octet”—a more comprehensive model of type 2 diabetes than the traditional triumvirate [45:45]; The kidneys' unexpected role in worsening diabetes, and how SGLT2 inhibitors were developed to treat diabetes [55:45]; How insulin resistance in the brain and neurocircuitry dysfunction contribute to overeating and metabolic disease [1:04:15]; Lipotoxicity: how overeating fuels insulin resistance and mitochondrial dysfunction [1:07:30]; Pioglitazone: an underappreciated and misunderstood treatment for insulin resistance [1:10:15]; Metformin: debunking the misconception that it is an insulin sensitizer and explaining its true mechanism of action [1:19:15]; Treating diabetes with triple therapy vs. the ADA approach: a better path for diabetes management [1:24:00]; GLP-1 agonists, the Qatar study, and rethinking diabetes treatment [1:31:30]; Using a hyperglycemic clamp to look for genes that cause diabetes [1:45:15]; The superiority of measuring C-peptide instead of insulin to assess beta-cell function [1:46:45]; How GLP-1-induced weight loss affects muscle mass, the benefits and risks of myostatin inhibitors, and the need for better methods of evaluating functional outcomes of increased muscle mass [1:51:30]; The growing crisis of childhood obesity and challenges in treating it [2:02:15]; The environmental and neurological factors driving the obesity epidemic [2:07:30]; The role of genetics, insulin signaling defects, and lipotoxicity in insulin resistance and diabetes treatment challenges [2:11:00]; The oral glucose tolerance test (OGTT): detecting early insulin resistance and beta cell dysfunction [2:18:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this fascinating episode, I dive into an incredible chat with the renowned Dr. Elizabeth Yurth. Known for her expertise in longevity, biohacking, and cellular medicine, Dr. Yurth shares game-changing insights into how repurposed drugs and peptides can enhance weight loss and promote longevity. We tackle the secrets behind microdosing treatments and repurposing drugs like Cialis for vastly improved vascular health, cognitive function, and even better orgasms for women! Trust me, you'll be jotting down notes at lightning speed as she breaks down how these unconventional methods can transform your health journey. But wait, there's more! We also discuss the mystery of peptides and bioregulators, crucial allies in the quest for enhanced healing and immunity. And yes, we even dive into hormones and anabolics, revealing how they can be your secret weapon to achieve peak physical and mental performance. Whether you're battling weight gain, fatigue, or just want to boost your badass meter during perimenopause and menopause, Dr. Yurth's insights are pure gold. Episode Key Insights: The role of repurposed drugs like Cialis in improving vascular and mitochondrial health. Metformin's impact on longevity and its downsides related to muscle loss. The use of GLP1 agonists for metabolic health and longevity without muscle loss. Rapamycin's potential as a powerful longevity drug when cycled properly. The benefits and potential side effects of low dose naltrexone for autoimmune diseases. Amlaxinox's role in reducing inflammation and its unexpected weight loss benefit. The importance of peptides, especially thymus-derived ones, for maintaining health and longevity. The versatility of peptides like BPC and Thymus beta 4 in promoting healing and repair. Anabolic steroids like oxandrolone and nandrolone for muscle and bone health, with less androgenic effects. The emerging role of bioregulators and their potential benefits for circadian rhythm and adrenal support. Connect with Dr. Elizabeth Yurth: Boulder Longevity Institute (BLI): https://boulderlongevity.com/ BLI's Human Optimization Academy: https://bli.academy/ Follow @dryurth Podcast Ad: Hormone Solutions by Karen Martel https://karenmartel.com/shop/?wpam_id=5 Use Code: DRAMIE for 10% off WHAT DO MY LABS MEAN?! Try the ultimate tool to Decode Your Labs: Understand your thyroid, hormones, and blood sugar numbers to transform your health https://dramie.com/labs/ We prescribe to all 50 states!  When you're ready to FINALLY get the help you deserve… Book a free application call: https://dramie.com/book-a-call/ Shop ALL of Dr. Amie's Fixxr® Supplements: https://betterlifedoctor.com/ EARN CE Credits: "Nurses, hold-on – here comes the exciting part: you can earn nursing CE credits by listening to our podcasts! That's right—RNegade has teamed up with podcast hosts like me who are delivering amazing content that doesn't limit you to “thinking outside-the box,” it challenges you to BLOW-UP the box by learning from innovators, pioneers, and RENEGADES in the field of health and medicine WHILE EARNING YOUR CEs!” https://rnegade.thinkific.com/?ref=4d98d0 CONNECT WITH ME ON SOCIAL MEDIA: Want to get your labs reviewed and your questions answered LIVE by me? Join my exclusive Facebook group, Just Fix Your Thyroid – a supportive and empowering community designed to give you the tools, guidance, and HOPE you need on your thyroid and hormone journey.

Dr. Kahn is hosting an online Reversing Heart Disease Summit. You can register now at: drtalks.com/summit/reversing-heart-disease This week, he takes a deep dive into the potential role of metformin as a drug for cancer prevention, diabetes management, and anti-aging, reporting on several new studies, including the MeMeMe randomized trial. The data is compelling. He also discusses several key topics, including a new study on statins reducing dementia risk, Omega-3's role in slowing aging, the hidden harms of juicing, microplastics in the brain, menopause and artery health, luteolin for dark hair, and the impact of telemedicine coaching on diabetic heart patients.

I am delighted to have Dr. Alexandra Sowa joining me for our second conversation today. Dr. Sowa is a pioneer in obesity medicine, known for combining scientific expertise with compassionate patient advocacy. She is also the author of the new Ozempic Revolution book.  In our discussion, Dr. Sowa shares her insights on GLP-1 medications and their role in metabolic health and weight management, and we tackle some of the biggest misconceptions about these drugs, exploring the differences between Metformin and GLP-1s and examining the damaging effects of ultra-processed foods have on our brains. We discuss the impact of the body positivity movement, yo-yo dieting, and microdosing, and Dr. Sowa offers her perspective on metabolic adaptation. We dive into the science behind how GLP-1s work in the body and some specific concerns about their side effects, and we also provide practical guidance on insurance coverage and answer a broad range of listener questions.  I know you will love this invaluable discussion with Dr. Alexandra Sowa. IN THIS EPISODE YOU WILL LEARN: Dr. Sowa shares her experience with GLP-1 medications Why you must understand your metabolic health before starting with GLP-1s Some of the broader benefits of GLP-1 medications Dr. Sowa explains what food noise is and clarifies how GLP-1 medications can help reduce it Why healthy-at-any-size and GLP-1 medications are not mutually exclusive Why is Dr. Sowa opposed to microdosing? The importance of using GLP-1s for health benefits rather than thinness How yo-yo dieting impacts metabolic health The mechanism of action and side effects of GLP-1s Some tips for navigating insurance coverage and accessing GLP-1s The importance of protein and the benefits of low-carbohydrate diets for individuals with insulin resistance Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Alexandra Sowa On her website   On all social media: @alexandrasowamd  Purchase a copy of Dr. Sowa's book, The Ozempic Revolution: A Doctor's Proven Plan for Success to Help You Reverse Obesity, End Yo-Yo Dieting, and Protect Yourself from Disease

EP. 190: What if the key to not dying early—or at least living vibrantly—boils down to one thing? Metabolic health. In this episode, I sit down with Dr. Ben Bikman, one of the world's leading experts on insulin resistance & metabolic health. Dr. Bikman is a professor at Brigham Young University and the author of Why We Get Sick, a groundbreaking book that exposes how modern lifestyles are fueling diabetes, obesity, and heart disease. We break down: Why insulin resistance is the root cause of so many chronic conditions The real impact of GLP-1s on metabolism and fat cells The latest cutting-edge research on muscle and GLP1 from Dr. Bikman's lab at BYU What you can do today to take back control of your metabolic health How Insulin Resistance Fuels Chronic Disease—and What to Do About It The Surprising Role of Fat Cells in Metabolism and Hormone Balance Why ‘Eat Less, Move More' Fails Most People—and What Works Instead GLP-1s and Satiety: The Science Behind Appetite and Metabolic Control Cutting-Edge Metabolic Health Research from BYU That Could Change Everything Simple, Science-Backed Strategies to Boost Testosterone Naturally If you care about your hormones, metabolism, and long-term vitality, this episode is a must-listen. Join my FREE 21-Day Strength & Resilience Challenge to get started: www.drtyna.com/strengthandresilience Sponsored By: Timeline Timeline is offering 10% off your order of Mitopure. Go to timeline.com/drtyna.  Puori Go to Puori.com/drtyna and use code DRTYNA to get 20% off Purity Woods Go to puritywoods.com/DRTYNA or enter DRTYNA at checkout for 27% off Sundays Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. BIOptimizers For an exclusive offer go to bioptimizers.com/drtyna and use promo code DRTYNA On This Episode We Cover:  00:00:00 - Introduction 00:01:57 - Teaching at BYU 00:03:32 - Dr. Ben's books 00:05:42 - Defining insulin resistance 00:10:14 - Insulin resistance and chronic disease 00:17:50 - Viruses and fat cells 00:19:56 - Fast vs. slow insulin resistance 00:26:21 - Overfilled fat cells 00:28:24 - Issues with the “Eat less & exercise more” approach 00:31:27 - Genes and metabolic health 00:32:12 - Satiety & GLP-1 response 00:37:25 - Appetite control vs. suppression 00:39:22 - GLP-1 dosing 00:42:33 - Hormones and metabolism 00:48:13 - Estrogen replacement therapy and testing 00:51:57 - AMPK, mTOR, and supplementation 00:57:57 - Metformin study 00:59:46 - Easiest ways to increase testosterone Further Listening: 10 Health Trends We Are Ditching in 2025 | Solo Kick Off 2025 with Strength, Resilience & Purpose | Quick & Dirty The Surprising Health Connections Between You and Your Dog | Quick & Dirty Check Out Dr. Ben: Instagram Website Books Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Kavita: Your work has been a blessing to me! I have a time-sensitive question. My husband (61) has been experiencing severe pain in his right toe, affecting his ability to lift his leg. Although magnesium foot soaks and oil massages provided some relief, the pain persisted. During the holidays, he had his condition checked and was told it might be nerve-related, possibly due to his medications. He is pre-diabetic, on Metformin, and takes statins. His bloodwork showed elevated blood sugar (200) and an A1C of 11, which was shocking since he generally maintains a good diet and exercises regularly.He sees his PCP tomorrow. I am not a big believer in traditional medicine. DR. CABRAL PLEASE HELP!                       C: female age 39. i have/had an "inflamed liver" my liver area hurts basically is what i understand. this started after i was a 8 weeks into a caloric restriction aiming for about 2 lbs a week loss. my doctor gave me a liver panel and my alt was elevated. about 2 months later i felt better . i just finished a 7 day eqilife detox and it started hurting agian. i am at a loss for what is going on or how to make it better and my doctor was no help to me. really she offered no information what so ever but to stop exercising.                                                                                                                                                       Lyn: Hi Dr. Cabral! I just received my annual bloodwork, and my TSH is at 4.9 while all my other markers are normal (antibodies, T3, T4, reverse T3, T4). I have struggled with higher levels of TSH for years which fluctuates between 3-5. I have definitely listened to all your podcasts concerning the thyroid, but I just can't seem to change these numbers. I also notice that if I take anything with Iodine, the numbers go quite high. I have heard that this is normal for around 6 months -1 year as your thyroid is balancing out, but I wanted to get your thoughts. Thanks so much!                                                         Carrie: Hi Dr. Cabral. I just received my bloodwork and am stumped. It's the same as last year almost even though I've tried even more to get these fixed. My WBC count is low with neutrophils dropping even more and ALT and AST slightly elevated, and when I worked with your team in the past and others, I have been told this is some sort of virus like EBV. I never drink alcohol and all other liver markers are normal and I'm running a functional medicine protocol with a lot of biomarkers. In addition, my total iron and iron saturation are high while my ferratin is only 19. I actually donated blood last year after I saw the high iron score, but it's still high. I listened to your most recent podcast on iron, but those cofactors seem fine. I'm disheartened and stumped!                                                                                     Esmira: Hello, Do you know what the underlying cause of cherry angiomas is and how to get rid of them? Thank you           Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3285 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter introduces a brand-new roundtable format. Joined by three renowned experts in longevity science—Steven Austad, Richard Miller, and Matt Kaeberlein—the group explores the rapidly evolving field of geroscience. Together, they dive deep into topics like the relationship between healthspan and lifespan, evaluating interventions like rapamycin and senolytics, the role of epigenetic changes in aging, and whether GLP-1 receptor agonists hold geroprotective potential. They also tackle major challenges in funding and public acceptance of longevity research including how geroprotective interventions might be tested in humans. Packed with nuanced debate, humor, and groundbreaking insights, this episode is a must-listen for anyone fascinated by the science of aging. We discuss: The recent rise in public interest in longevity, misconceptions, and the link between healthspan and lifespan [3:45]; Redefining healthspan, the US healthcare paradox, and separating longevity science from commercial hype [12:30]; The need to redirect medical research from disease-specific models to aging-focused approaches [21:30]; Proactive healthcare: rethinking health, disease, and the role of aging [30:00]; Biologic age versus chronologic age, and the limitations and potential of epigenetic clocks [35:00]; The utility and drawbacks of the “hallmarks of aging” as a framework for research and funding [49:30]; The role of epigenetic changes in aging and the challenges of proving causality [56:45]; The translational challenges of moving aging research from preclinical studies to human applications [1:03:45]; Distinguishing between a biomarker of aging and aging rate indicators [1:17:15]; The difficulties of translating longevity research in mice to humans, and the difficulties of testing interventions in humans [1:21:15]; Exercise, aging, and healthspan: does exercise slow aging? [1:35:45]; Are GLP-1 receptor agonists geroprotective beyond caloric restriction effects? [1:41:00]; The role of senescent cells in aging, challenges with reproducibility in studies, and differing views on the value of current research approaches [1:46:15]; How funding challenges and leadership in NIH and other institutes impact the advancement of aging-related research [2:00:15]; Metformin: geroprotective potential, mechanisms, and unanswered questions [2:02:30]; Canagliflozin and rapamycin as geroprotective molecules: mechanisms, dosing strategies, and longevity potential [2:10:45]; Resveratrol and NAD precursors—a lack of evidence for anti-aging effects [2:22:45]; The potential of parabiosis and plasmapheresis to slow aging, the challenges in translating mouse studies to humans, and possible design for human studies [2:29:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this episode, you'll get to explore cutting-edge strategies and science-backed insights to help you recover faster, build strength, and make smarter health decisions. You'll start by discovering some of the most effective ways to optimize recovery after surgery—like cutting out processed sugars and seed oils to reduce inflammation, incorporating nutrient-rich foods like bone broth and collagen, and following a Paleo autoimmune diet to minimize post-surgical complications. I also dive into key supplements, including amino acids, anti-inflammatory peptides, and high-dose vitamin C, alongside advanced tools like hydrogen tablets, red light therapy, and the mitochondrial triad of C60, methylene blue, and red light. This episode is packed with actionable advice to help you heal, strengthen, and thrive. Grab a notebook and dive into these powerful insights for a healthier, more vibrant life! Full show notes: https://bengreenfieldlife.com/484 Episode Sponsors Qualia: Visit qualialife.com/boundless and use code BOUNDLESS for 15% off your order. Peluva: Visit Peluva.com peluva and use the the code BEN For 15% off your first pair! Peluva's let your feet be feet! Organifi: Go to Organifi.com/Ben for 20% off your order. LeelaQ: Visit leelaq.com/ben and use code BEN10 for 10% off. Lumen: Optimize your metabolism with Lumen! Gain personalized insights for better energy, weight management, fitness, and sleep. Lumen even adapts to hormonal changes to keep you feeling your best. Take the next step at lumen.me/GREENFIELD and get 20% off!See omnystudio.com/listener for privacy information.