Podcasts about Metformin

Today, I am blessed to have here with me Dr. Amie Hornaman DCN, MsN, CFMP. She is also known as The Thyroid-Fixer, a woman on a mission to optimize thyroid patients around the world and give them their lives back using her transformation program: The COMPLETE Thyroid Fix Method (CTFM). After her own experience of insufferable symptoms, misdiagnoses and improper treatment, Amie set out to help others who she KNEW were going through the same set of frustrations and who were on the same medical roller coaster. She grabs your hand, gives you answers about your health that no one has told you and gives you the actual tools and treatment to fix you. That's the transformational journey. With a focus on optimizing thyroid function and thus optimizing her patients, Amie looks at each person as a unique individual and not JUST a lab value. She examines all factors that tie into thyroid dysfunction and thyroid symptoms and treats the person from top to bottom to give them their lives back. In this episode, Dr. Amie opens up about her experience with health issues as a fitness model. Despite cleaning up her diet and exercising, Dr. Amie was gaining weight. After seeing six doctors, finally, Dr. Amie was diagnosed with hypothyroidism. Dr. Amie speaks about knowing if you have a thyroid disorder and the role insulin resistance plays in your thyroid. Later, we talk about the benefits of keto and fasting when it comes to your thyroid. Tune in as we chat about berberine, toxins, and how to feel in control of your life. Register your FREE spot for the next 7 day keto kickstart challenge with Dr Jason Fung, Dr Ken Berry, Dr Annette Boz and many others: http://www.ketokampchallenge.com  Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E   S P ON S O R S  Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. Get Bioptimizers Magnesium Breakthrough for the best night of sleep, ever! Replenish your magnesium levels, and master stress. Visit magbreakthrough.com/ketokamp Use the coupon code ketokamp10 for 10% off.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  [00:35] Gaining Weight and Experiencing Health Issues As A Fitness Model At one particular fitness show, Dr. Amie started gaining weight instead of losing it. Everybody knows their body. You know when your body is off. Plus, Dr. Amie was tired, and her hair was falling off. The doctor told her to eat less and exercise more. For Dr. Amie, that wasn't possible. Six diagnoses later, a doctor said she had hypothyroidism. [04:15] How Long Does It Take For Conventional Medicine To Diagnose A Thyroid Disorder? Doctors are looking at a standard lab range, which is huge. So, it's challenging to know about thyroid problems with conventional medicine. Some people see between six and ten doctors before learning about hypothyroidism. Amie knows someone who saw forty doctors before she was diagnosed with hypothyroidism. It's different for everyone. However, if you know something is wrong with your body, then you can't stop searching for answers. [05:05] The Symptoms To Pay Attention To For Thyroid Disorders You may have a thyroid disorder if you are gaining weight with proper diet and exercise. There are other symptoms of thyroid disorders: Hair loss Fatigue Constipation Hypo is low and slow. Your mood will be depressed, your energy will be down, and your ability to burn fat will be down. [11:55] The Role Insulin Resistance Plays With An Underactive Thyroid “I see insulin resistance in about 99% of my thyroid patients.” -Dr. Amie The thyroid gland is the ultimate master gland of all of your trickle-down hormones. If we are living a lifestyle of high carbs and high sugar, we are actually causing insulin resistance. This type of lifestyle does produce a ton of inflammation. High insulin levels will inflame the thyroid and cause the thyroid to not produce enough hormones. Inflammation is beating up the thyroid gland. [14:00] True or False: You Cannot Do Keto With An Underactive Thyroid False! Keto is by far the best way of eating for hypothyroid patients. When there is inflammation, keto can be a total game-changer. Keto will improve inflammation. Therefore, you can improve your thyroid production. [20:30] Is Long-Term Ketosis A Good Idea For People With An Underactive Thyroid?   Being in ketosis for years without a break can lower your 3T3 levels. Usually, it's not a huge issue because it only lowers those levels a little bit. Instead, Dr. Amie says to come out of ketosis everyone once in a while. Break out of ketosis; that's all you need to do. Eat a sweet potato once a week. It will keep your thyroid gland active. [28:20] True or False: You Can't Fast With A Thyroid Issue False! When we're talking about the thyroid, we have to take into account the adrenal glands and cortisol production. Adrenal fatigue is blown out of the water a little bit too much. We do have to think about stress on the body and how it's going to affect your cortisol production. You can't deny the benefits of fasting. If you wake up and you are not hungry, do not shove food down your mouth. If you wake up hungry, then eat. Your body gives you signals all the time; listen to them! [33:00] Always Choose To Focus What Is Within Your Control 80% you can control; 20% you can't control. You can control your choices and what you put into your mouth. Also, you can choose what products you put on your body. Make sure you limit down your exposure to toxins. If you try to be perfect, you're just going to be at a standstill. [36:00] Say Yes To Berberine: Incredible Health Benefits of This Supplement Berberine works like Metformin. The supplement will squish the highs and lows of your blood sugar. Also, berberine has beneficial effects on the gut microbiota. Lastly, berberine is beneficial to the GI tract. [40:15] Dr. Amie Gives You Action Steps To Take Right Now Get a full thyroid panel and look at it from a functional lens. Eat a keto diet and fast. Lastly, get restful sleep. It's the foundation of health! AND MUCH MORE! Resources from this episode: Check out Dr. Amie's Website: https://dramiehornaman.com/ Listen to The Thyroid Fixer: https://dramiehornaman.com/podcasts/ Follow Dr. Amie Facebook: https://www.facebook.com/amiehornamannutrition YouTube: https://www.youtube.com/channel/UCHSBsf69l5v1iP97BaqSC0w Instagram: https://www.instagram.com/dramiehornaman/ Listen to Keto, Fasting and The Thyroid with Ben Azadi: https://www.buzzsprout.com/1278842/9149903 Join theKeto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Register your FREE spot for the next 7 day keto kickstart challenge with Dr Jason Fung, Dr Ken Berry, Dr Annette Boz and many others: http://www.ketokampchallenge.com  Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E   S P ON S O R S  Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. Get Bioptimizers Magnesium Breakthrough for the best night of sleep, ever! Replenish your magnesium levels, and master stress. Visit magbreakthrough.com/ketokamp Use the coupon code ketokamp10 for 10% off.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

In today's episode, host Barbara Hannah Grufferman welcomes frequent guest, Dr. Margaret Nachtigall, to talk about metformin: what it is, what it does, and how it might help you age better.  Some things you will learn about metformin during the discussion include:  What is metformin?   Metformin is an oral medication commonly prescribed to treat type 2 diabetes. It works by decreasing the amount of glucose (sugar) produced by the liver and also helps the body to respond better to insulin, a hormone that regulates blood sugar levels.   What are some of the most common 'off label' uses for metformin?  Although metformin is primarily used to treat type 2 diabetes, it has also been found to be effective in treating several other medical conditions. These uses are considered "off-label" because they are not approved by regulatory agencies such as the FDA for these specific conditions. Some of the most common off-label uses for metformin include:  Polycystic ovary syndrome (PCOS): Metformin can help regulate menstrual cycles and improve insulin resistance, which can reduce symptoms associated with PCOS, such as irregular periods, acne, and excessive hair growth.  Obesity: Metformin can help with weight loss by reducing appetite, increasing feelings of fullness, and reducing the absorption of carbohydrates in the gut.  Metabolic syndrome: Metformin can help improve insulin resistance, lower blood sugar levels, and reduce high blood pressure and high cholesterol levels associated with metabolic syndrome.  Non-alcoholic fatty liver disease (NAFLD): Metformin can improve liver function and reduce inflammation associated with NAFLD.  Cancer prevention and treatment: Some studies suggest that metformin may have anti-cancer properties and can help reduce the risk of certain types of cancer, such as breast, colon, and prostate cancer.  Why are longevity researchers promoting metformin?  Longevity researchers are interested in metformin because of its potential to extend lifespan and improve healthspan, which is the length of time an individual remains healthy and free from chronic diseases. Metformin has been shown to activate a pathway called AMP-activated protein kinase (AMPK), which plays a key role in regulating cellular metabolism and energy homeostasis. AMPK activation leads to a variety of effects that are beneficial for aging and age-related diseases, including improved insulin sensitivity, reduced inflammation, and increased autophagy, which is the process by which cells remove damaged proteins and organelles.  While more research is needed to fully understand the effects of metformin on lifespan and healthspan in humans, some longevity researchers are promoting metformin as a potential anti-aging drug. However, it's important to note that metformin should only be taken under the guidance of a healthcare provider and that more research is needed to determine its long-term safety and efficacy for anti-aging purposes.  Does metformin help reduce the severity of long covid?  There is some evidence to suggest that metformin may be helpful in reducing the severity of long COVID, although more research is needed to fully understand its potential benefits. In fact, a new study, just released, showed that early treatment with metformin reduced the risk of long COVID among outpatients.   Metformin has been shown to have anti-inflammatory and immunomodulatory effects, and it may also have antiviral properties. Based on these effects, some researchers have proposed that metformin may be helpful in reducing the severity of long COVID symptoms.  Connect with Barbara:  Website: https://www.barbarahannahgrufferman.com  Instagram: @Barbara Hannah Grufferman  Facebook: @BarbaraHannahGruffermanAuthor  Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode of The Dr. Tyna Show, I am going solo to talk to you about why movement overrides pain.On This Episode We Cover:1:34 - Physiology 1014:27 - What is synovitis?7:12 - When chronic pain becomes a real problem8:00 - What degrades collagen12:50 - Why you may not be healing properly15:45 - Metformin and long COVID23:30 - Angiogenesis26:20 - How and why to improve your metabolic health30:14 - Why I love blueberries33:22 - Why movement overrides pain36:00 - Where and how to start38:18 - What exercise does for the brain43:34 - Things that help with microglial hyper activation or brain on fire syndrome45:19 - What happens to your brain when you get put on opioids47:07 - My strength training platform48:25 - T cell and T cell responseMetabolic Revamp can be found at drtyna.comJoin me on my NEW exclusive strength training platform where I'll be sharing workouts, teaching proper and safe form with strength training from a rehab based perspective, talking all things metabolic health and hormones, plus much more! You can sign up via my website at drtyna.com.Further Listening:You Are Not Your Diagnosis - Solo Episode Get full access to Dr. Tyna Show Podcast & Censorship-Free Blog at drtyna.substack.com/subscribe

Let's discuss how how different macronutrients and blood sugar issues can regulate aging and the induction of cellular senescence. We also discuss how various dietary interventions can achieve prevention of disease and extension of lifespan by modulating senescence. Sponsored Message: Support your Intermittent Fasting lifestyle with the updated Berberine HCl Fasting Accelerator by MYOXCIENCE: Use code podcast to save 12% Link to Articles & Images: https://bit.ly/42kjEen Show Notes: 00:25 Cellular senescence accelerates biologic ageing. 02:00 Senescent cells are enlarged, have dysfunctional mitochondria, and release pro-inflammatory signaling molecules. 02:30 Senescence manifests as wrinkles, memory loss, muscle loss, gray hair, fatty liver, excessive visceral adipose tissue. 03:45 Senescence occurs in response to stressors or developmental signals and behave similar to cancer cells. 05:45 Dysfunctional mitochondria influences glycolysis in cells. 06:15 Give your cells less fuel, glucose, for the proliferation of inflammation. 07:45 Hyperglycemia decreases nitric oxide, which helps prevent cellular senescence. 08:00 Sirtuins can inhibit the formation of senescent cells. 08:55  Berberine, Metformin, and low dose rapamycin, have been used to mitigate hyperglycemia. 10:30 Hyperglycemia also impacts your cardiovascular system and endothelial cells. 12:00 Fat cells can become senescent. 13:00 Ketones (BHB) can help inhibit cellular senescence. 13:25 Optimized omega 3 to omega 6 ratio can help. 14:00 Exercise counters age-related accumulation of senescent cells. 14:40 Senescence within your immune cells is linked with cancer and poor response to infection.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter focuses the discussion on two topics getting a lot of attention recently. He first dives deep into GLP-1 agonists, most notably semaglutide and tirzepatide, which originally came to market as diabetes drugs but are now being studied and prescribed for weight loss. He walks through the data and compares the effectiveness of the two drugs, the side effects, and perhaps more importantly, his reservations around wide use of these drugs and who he would consider to be a candidate for them. Next, Peter discusses how metformin, another drug originally brought to market for diabetes management, gained popularity as a potential longevity drug even for non-diabetics. Peter gives his take on this possibility and reviews data from a more recent study investigating the question of whether metformin should be used for general “geroprotection.” If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #45 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: The hype around semaglutide, tirzepatide, and other GLP-1 agonists for weight loss [2:30]; Overview of GLP-1 agonists and why these drugs are getting so much attention [6:15]; Defining the term “geroprotective” [13:30]; Semaglutide: background, brand names, indications, and more [15:15]; Tirzepatide: background, brand names, indications, and more [19:15]; How semaglutide and tirzepatide compare in their efficacy in terms of weight loss and other metabolic health metrics [23:45]; Data showing sustained weight loss and improved metabolic metrics with after more than a year of using semaglutide and tirzepatide [29:00]; What happens to body weight when a patient discontinues the medication? [34:45]; Noteworthy side effects of GLP-1 agonists and similar classes of drugs [40:45]; Increased resting heart rate and other concerning trends in patients using GLP-1 agonists [45:15]; Changes in body composition (body fat and lean muscle) in patients on GLP-1 agonists [50:45]; Possible reasons for the loss of lean muscle mass and tips for protecting lean mass [59:00]; GLP-1 agonists and thyroid cancer [1:01:30]; Who might be a candidate for GLP-1 agonists? [1:03:45]; The large financial cost of this class of drugs [1:08:30]; Metformin as a geroprotective drug: origin of the idea that metformin could be a longevity agent even for non-diabetic patients [1:11:30]; A 2022 study on metformin sheds more light on the question of whether metformin should be used for “geroprotection” in non-diabetics [1:21:00]; Peter's current approach with metformin for his patients [1:25:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this episode, my guest is Satchin Panda, PhD, professor and the director of the Regulatory Biology Laboratories at the Salk Institute for Biological Studies. We discuss his lab's discovery that “time-restricted eating” (TRE) aka intermittent fasting, is beneficial effects for metabolic health and longevity. Dr. Panda explains how TRE, and also longer fasts, can positively impact obesity, diabetes, cardiovascular health, age-related chronic diseases, and improve mood and cognitive performance. He also describes how the timing of eating, light exposure and exercise that ~50% of all people engage in, negatively impacts their health and explains how specific simple adjustments to these can positively shift their subjective feelings of health and biomarkers of cardiovascular function, glucose regulation and metabolism. We discuss how our circadian behaviors, which include our patterns of eating, sleeping and socializing, have an enormous impact on our biology, mood and health and how by simply confining our calorie consumption to a semi-regular daily window, can positively impact our physical health, mental health and longevity. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman HVMN: https://hvmn.com/huberman Eight Sleep: https://eightsleep.com/huberman Thesis: https://takethesis.com/huberman Momentous: https://www.livemomentous.com/huberman InsideTracker: https://www.insidetracker.com/huberman Timestamps (00:00:00) Dr. Satchin Panda (00:03:02) Sponsors: HVMN, Eight Sleep, Thesis, Momentous (00:07:24) Time-Restricted Eating (TRE), Calorie Restriction (CR) & Health (00:14:38) Mealtimes & Circadian Clock (00:21:34) Circadian Rhythm, Meal Anticipation, Digestion (00:25:28) Breaking a Fast, Burning Fat (00:32:49) Sponsor: AG1 (Athletic Greens) (00:34:04) CR, Time Restricted Eating, Circadian Rhythm & Longevity (00:47:20) Gender, Hormones & CR; Relative Energy Deficient in Sports (REDS) (00:52:40) Physical Activity, Nutrition & Feeding Window (00:59:04) Nutrition Timing, Quality & Quantity; Low- Carbohydrate Diet (01:03:00) Caffeine, Nighttime Socialization, Fire, Breakfast (01:15:07) Sponsor: InsideTracker (01:16:20) Circadian Rhythm, “Night Owls” & Genetics (01:26:37) Morning vs. Nighttime Discussions, “Me Time” (01:30:08) Light Sensitivity & “Night Owls”; Puberty, Melatonin (01:36:05) Shift Workers, Health & Disease (01:45:43) Artificial Lights, Young Adults & Sleep, Metabolic Dysfunction (01:50:59) Firefighters, Sleep & TRE; Cardiovascular Health, Blood Glucose (02:05:18) Shift Workers & Sleep; Alcohol & Caffeine (02:09:15) 12- Hour Feeding Window for Adults & Children, Sleep (02:22:10) Meal Timing (02:25:20) “Complete Fast”, Longer Fasts, Physical Health & Mental Health (02:28:12) “Fat Fasting”, Blood Glucose & Insulin (02:31:57) Fasting, Metformin, Rapamycin & Longevity; Human Applicability? (02:39:14) Circadian Rhythm & Metabolism (02:41:36) Ontime Health App, Circadian Clock App (02:46:17) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

@michaelsalzle Metformin and it's effect on the hallmarks of aging https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/#abstract-1title

Let's discuss more about cancer, sugar and The Warburg effect.  Support your Workout Sessions and Healthy Hydration with the Electrolyte + Creatine Combo by MYOXCIENCE : https://bit.ly/electrolyte-stix  Use code podcast to save 12% Link to study & Images: https://youtu.be/I6_QmMuluiE Show Notes:  0:00 Intro 0:05 Breast, lung, colon, and brain cancer have been linked with deranged cellular metabolism.  0:27 Cancer is the second leading cause of mortality in the US.  1:00 Normal cells aerobically breakdown carbohydrates and fats to create ATP. 1:50 Cancer cells, in the presence of oxygen, ferment glucose to make pyruvate and lactate.  3:10 Mitochondria regulate preprogrammed cell death.  5:10 Dysregulated glucose metabolism fosters a tumor microenvironment that favors expansive growth.  5:35 PET scan is diagnostic imaging tool which uses a radioisotope glucose, fluorodeoxyglucose, that helps to diagnose cancer. 7:00 Metformin, which decreases glucose, is being used in cancer treatment and therapeutics. 9:10 Tumors require a chronic overexpression of lactate. Exercise is a transient acute increase in lactate. 10:04 Lactate can cause a cascade of events which helps the tumor grow more blood vessels. 11:25 By circumventing mitochondria for energy, it's ability to induce apoptosis is inhibited. 13:00 Your microenvironment can foster or inhibit the growth of a tumor. 14:45 Cold immersion is a mitochondrial therapy.  15:40 There is an association with a lower risk for breast cancer, total cancers and colorectal cancers for people who follow dietary prevention guidelines.

In today's episode, I sit down with Macy Schuchart the founder of Ancient Bliss a Herbal Organic supplement company. Show Notes:www.AncientBliss.comInstagram Handle: Anceint.bliss20% Discount Code: KEN20 Visit My Diabetes Coaching Websitewww.SimplifyingDiabetes.comSend me an email or DM me on Instagram and I'll answer any question you have about Diabetes.Don't forget to click on that subscribe button and leave a 5-star review on any platform you listen to the podcast, so you're notified when new episode drop. Questions about diabetes, don't hesitate to reach out @:Instagram: @thehealthydiabeticpodTwitter: @thehealthydpodTik Tok: @thehealthydiabeticpodFacebook: @Simplifying Life With DiabetesEmail: ken@simplifyingdiabetes.comPodcast Disclaimer: Nothing that you hear on The Healthy Diabetic Podcast should be considered medical advice or otherwise; please always consult your medical TEAM before making any changes to your diabetes management.

In part 1 Dr. Mike Stone and Trei Trackett discussed how effective traditional health pillars can be on longevity - in part 2 they discuss additional strategies. Such as state of the art tests for biological age, how these tests work, what's happening at a cellular level as we age and during interventions. They explain the deep science behind why protocols like fasting are so beneficial for longevity and what misinformation is out there around longevity. Stay tuned for part three where they discuss molecules like NAD, Quercetin, Metformin and more.

@michaelsalzle. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/#abstract-1title

Should we start prescribing metformin to our patients on clozapine? In this episode, we discuss several articles on the efficacy of clozapine in preventing clozapine-induced weight gain, including some evidence on when metformin is more effective. Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.5 CMEs: Quick Take Vol. 42 Metformin for the Prevention of Clozapine-Induced Weight Gain: A Retrospective Naturalistic Cohort Study

Metformin and Muscle Loss

It's In the News, a look at the top stories from the diabetes community from the last seven days. This week: Cost Plus pharmacy starts putting out feelers about insulin, asking people to take part in a pilot program, EO Flow looks at the US market for their new patch pump, quite a few new studies about type 2 diabetes drugs, a study about slowing down type 1 in kids and much more! Learn more about the T1D exchange and drive research that matters! www.t1dexchange.org/stacey Check out Stacey's books! Join the Diabetes Connections Facebook Group! Sign up for our newsletter here Episode Transcription Below (or coming soon!) Please visit our Sponsors & Partners - they help make the show possible! *Learn more about OMNIPOD* *Learn more about AFREZZA* *Learn more about DEXCOM* Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and these are the top diabetes stories and headlines of the past seven days. XX In the news is brought to you by The T1D Exchange - Help drive research that matters. XX Possible new player in the US Patch pump business. EO Flow has submitted a 510(k) application to the FDA for its EOPatch wearable, disposable insulin pump. EO Flow is based in California and has launched the pump in South Korea. The company also has FDA breakthrough device designation on an integrated artificial pancreas. The website says EOPancreas is a wearable disposable artificial pancreas system that integrates a continuous glucose sensor and an insulin pump in one small wearable module and autonomously controls insulin infusion. They're looking for a US partner for the pump and hope to launch in 2024. http://www.eoflow.com/eng/eopatch/eopatch_010100.html https://www.drugdeliverybusiness.com/eoflow-submits-insulin-patch-pump-fda-clearance/ XX Your time in range before getting a COVID vaccine may predict your body's response. This was a small study, 25 patients with type 1 who received two doses of a COVID vaccine. Researchers followed the group two weeks before before and six months after the shots. Main outcome measures: The primary exposure and outcome measures were pre-vaccination glucose control, and antibody response after vaccination, respectively. Patients meeting the recommended pre-vaccination glucose targets of TIR (≥70%) and TAR (≤25%), developed stronger neutralizing antibody titres (p < 0.0001 and p = 0.008, respectively), regardless of HbA1c. highlighting a role for well-controlled blood glucose in vaccination efficacy. https://pubmed.ncbi.nlm.nih.gov/36611249/ XX New study in kids with type 1 seems to show that the drug golimumab – brand name Simponi – can help preserve beta cell function. This is the Tiger study which included people ages 6 to 21 years old with T1D and given either the drug or a placebo for 52 weeks the off the drug for another year. The group taking the drug used less insulin and had a higher c peptide level in the time after the medication stopped, indicating that there was a difference. https://diabetesjournals.org/care/article-abstract/doi/10.2337/dc22-0908/148228/Two-Year-Follow-up-From-the-T1GER-Study-Continued?redirectedFrom=fulltext XX New study confirming what a lot of you already know, Metformin failure in people with type 2 diabetes is very common, particularly among those with high A1c levels at the time of diagnosis. An analysis of electronic health record data for more than 22,000 patients starting metformin at three US clinical sites found that over 40% experienced metformin failure. This was defined as either failure to achieve or maintain A1c less than 7% within 18 months or the use of additional glucose-lowering medications. "These results call into question the ubiquitous use of metformin as the first-line therapy and suggest a more individualized approach may be needed to optimize therapy," they add in their article published online in the Journal of Clinical Endocrinology and Metabolism. The investigators identified a total of 22,047 metformin initiators from three clinical primary care sites: the University of Mississippi's Jackson centers, which serves a mostly African American population, the Mountain Park Health Center in Arizona, a seven-clinic federally qualified community health center in Phoenix that serves a mostly Latino population, and the Rochester Epidemiology Project, which includes the Mayo Clinic and serves a primarily White population. https://www.medscape.com/viewarticle/986994 XX The FDA has approved a label update for semaglutide that allows the drug to be used in addition to diet and exercise as a first-line option to improve glycemic control in adults with type 2 diabetes. The brand name here is Wegovy. With its initial FDA approval in 2019, semaglutide became the first and only glucagon-like peptide-1 (GLP-1) analog in pill form. https://www.pharmacytimes.com/view/fda-approves-label-update-for-semaglutide-allowing-use-as-first-line-option-for-adults-with-type-2-diabetes XX Merk says it's diabetes drugs Januvia and Janumet have become contaminated with a potential carcinogen.. and it can resolve the problem by the end of the year. The company submitted a report to the U.S. Food and Drug Administration (FDA) and other regulators. The impurity arose mostly during storage, as well as during manufacturing, Bloomberg News said. The FDA said in August certain samples of sitagliptin, a compound in Merck's diabetes drugs Januvia and Janumet, were contaminated with a possible carcinogen. https://www.bloomberg.com/news/articles/2023-01-17/merck-mrk-ready-to-remove-cancer-linked-chemical-from-diabetes-drugs-in-2023 XX Researchers studying new methods for improving blood sugar control in type 2 diabetes have discovered an old class of antipsychotic drugs may offer clues to a novel kind of treatment for hyperglycemia. While the researchers propose the old drugs could be directly repurposed to treat diabetes, they could also be slightly modified to more specifically target blood sugar control. The class of drugs, known as (DPBPs), were developed back in the 1960s and are still used today. The researchers say they “They all improve blood sugar control by preventing the muscle from burning ketones as a fuel source.” Because the DPBP drugs are already approved medicines the researchers hope to quickly move to proof-of-principal human trials. This would establish whether these preclinical findings are reproducible in human patients. The new study was published in the journal Diabetes. https://newatlas.com/medical/old-antipsychotic-drugs-new-class-diabetes-treatment/ XX Another study showing an AID system works well for people with type 2. Scientists from University of Cambridge set up a small study, no surprise, the closed loop system did a lot better than standard injection therapy – people stayed in target range 66-percent of the time versus 32-percent with shots. That was an additional 8 hours a day of time in range. https://www.medicalnewstoday.com/articles/type-2-diabetes-artificial-pancreas-may-soon-be-an-option XX Dexcom gives us a little more information about the G7. I interviewed Kevin Sayer for this week's long format interview and he says the G7 will launch in the US during this first quarter.. so by the end of March. He also gave a more pessimistic view for interoperability with Tandem and Omnipod than we've heard – with Tandem end of summer early fall and Omnipod 5 next year. It's up to those companies, not Dexcom. XX T1D Exchange XX On the podcast next week.. how are those new year's resolutions going? If you haven't kept them up, maybe you tried to do too much at once? Nutritionist Ben Tzeel joins me to talk about how to get back on track. I mentioned last week's episode with Dexcom CEO Kevin Sayer. We talk about the G7 launch and lots more, including their plans for the type 2 community and moving into “health” That's In the News for this week.. if you like it, please share it! Thanks for joining me! See you back here soon.

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog I often see patients at the office who come back to get BBH Pellets after a hiatus of months to years, that they tell me waiting was the biggest mistake they ever made.  They were feeling so good after their hormones were replaced that they forgot how bad they felt before their treatment. Stopping their hormones brought back their symptoms, and they realize how much their pellets are doing for them! This is human nature, and often happens because when we feel better, we forget quickly how we felt before treatment.  The problem with starting and stopping pellet hormone replacement is that slowly all the symptoms come roaring back and then my patient wonders why they don't feel well.  Until they remember that the pellets made such a difference and come back. Stopping Hormone Pellets for No Apparent Reason Hormone Treatment with Pellets Is different than other medications because when a person stops therapy, pellets continue to dissolve slowly, so they continue to make our patients feel good before the pellet hormones wear out which can be 6 months for women and 12 months for men.  Because blood levels of testosterone and estradiol from pellets are slow to increase and slow to run out, patients don't notice an abrupt change.  Generally, months after an insertion was supposed to be repeated, the symptoms of hormone deficiency are evident but patients may not put it together with not getting their pellets on time. Other medications make it easier to recognize the cause and effect, because if you don't take a medication such as a diuretic or an ADD medication, you get the symptoms you are taking the drug for back in 24 hours.  Even oral, transdermal and suppository hormones have a half-life that is less than hours long, so if a patient is taking oral estrogen for hot flashes, then discontinuing treatment would bring an obvious return of hot flashes and dry vagina right away. That makes it easier to the return of symptoms with the stoppage of the oral hormones. Short acting hormones or drugs make it more obvious to a patient that they need to take their medication or get they will get their symptoms back. I have to ask my patients to consider their pellet treatment as a lifelong therapy like taking thyroid or blood pressure medicine. The result of stopping pellets is that a patient feels well for a while and then slowly goes back to their symptoms before pellets, and they don't put it together and look for other causes and other diseases without results, until they remember they didn't get their pellets inserted. This causes patients to delay feeling well and they don't get the benefits of symptom relief or prevention of the diseases of aging during the time without pellets. For those patients who put realize what is going on and comeback “late”, it takes months to years to get their hormones replaced and balanced again. Stopping Supplements Has a Delayed Response Too Let's look at another treatment that patients often stop and then don't know why they don't feel well. That is treatment with supplements.  Supplements slowly improve specific symptoms by either treating genetic deficiencies or deficiencies in your diet that take a month to 6 weeks to have an effect and that same amount of time to wear off. Let me tell you a story that is an example of this very thing.             I was at dinner with one of my friends who is also my patient. He had a knee replacement a month before.  His doctor asked him to hold the supplements that would cause bleeding at surgery 2 weeks before his surgery.  My friend is a type A guy who believes that a little is good and a lot is better, so he stopped all of his supplements. Then 4 weeks after surgery and 6 weeks after stopping all of his supplements, he sat at dinner with us and looked “deflated”…he complained that he just didn't feel good, and this was occurring more and more since his surgery.  He left dinner early because he just didn't feel well and that his symptoms had been getting worse over the last 2-3 weeks.  I did my usual casual questioning with a purpose—asked about his knee, pain meds, how long since his pellets, etc.  All his answers didn't give me a clue.  I went home and looked at his last labs and meds and supplements. I then talked to him and asked if her had gone back on the supplements his surgeon told him not to take?  He said, “I stopped taking everything two weeks before surgery!  I never restarted them.”  This “aha” moment hit at the same time for both of us…he needed his supplements both to heal and to replace the nutrients he didn't get in his diet. Supplements for patients who have no genetic deficiencies, who eat a perfect diet, who exercise daily and who have no bad habits or take drugs that would use up their nutrients, don't need supplements. I haven't seen a person who qualifies as too healthy for supplements including me and my husband. If there were a perfectly healthy patient who eats a perfectly balanced diet with enough fruit and vegetables, healthy protein, from home cooked meals without chemicals or preservatives, who eats no junk food or sugar containing food, and who doesn't drink alcohol or any medication. BioBalance Health uses supplements to make up for deficiencies in diet, or instead of medications for health issues. We make a plan based on a patient's risk factors obtained from their history and blood tests, and we explain why patients should take these supplements.  Lastly sometimes medications use up your enzymes and vitamins. For example, when a patient who was on a statin had fatigue and muscle aches, I prescribed CoQ10 because that important nutrient would be used up by the statin would be taken off the CoQ10 when they stop the statin. Patients who can't or won't add foods to balance their diet then we recommend the supplements that are needed to take instead of eating foods they don't like, but need. All patients on a weight loss diet require a multivitamin, protein supplements to increase the amount of protein eaten daily to more than ½ of the patient's weight in grams of protein. Some medications use up a normal supply of a certain vitamin.  An example is that the medication Metformin uses up B12 stores in the body so the patients taking metformin should be on B12 in a multivitamin, monthly shot, or a separate supplement to make up for the B12 the metformin uses up. The lack of B12 shows up as generalized pain, muscle pain, neurologic numbness or lower extremity neurological abnormalities.  Alcohol consumption is also another habit that uses up B12. All patients who drink alcohol more than occasionally should be on plenty of B12.  B12 cannot be overdosed because after you use what you need, you urinate the rest out through the kidneys. Another example of what happens when you stop taking supplements that are indicated by a patient's symptoms it takes weeks and months to feel the difference, or to get the original symptoms back.  A long-time pellet patient who would not go without her pellets, asked me if she could stop her supplements…she was just tired of taking them. In fact, she had stopped them months before and she had a “new list” of symptoms.  I did some lab to see what her blood levels were, and she had a low Vitamin D level, B12 level, her estrone was elevated (stopped taking DIM) and she was gaining belly fat and blaming pellets.  After a consultation, she decided to start taking her supplements again, and a month later she felt great and lost some belly fat!  Recommending supplements is part of our treatment that we provide with our preventive medical therapy for our Pellet patients. Supplements are not required but recommended to make up for the modern lifestyle, diet, alcohol, lack of sun exposure and exercise. The fact that the effects of supplements might be silent, causes patients to doubt their activity, and usefulness.  When all supplements are stopped we can often see a  subtle decrease  in a patient's symptom relief and overall well-being. Sometimes understanding why we as humans are apt to do things that make us less healthy or sicker sometimes makes it easier to follow recommendations of our doctors.  I see the benefits of vitamins, minerals and supplements that my patients take every day in their blood work and their symptoms.  Sadly the medical community, funded by the drug companies don't want us to take supplements….the medical studies they do on supplements always say they don't work…however they create a study that will result in no improvement by lowering the dose too low, shortening the period of taking a supplement or they choose their subjects so that NO drug or supplement will work.  You can make a study say almost anything you want it to… Don't stop your thyroid medicine! I live in the “Goiter Belt” in the middle of the US, so many of my patients need thyroid replacement, which resolves their low thyroid symptoms, and makes their lab look normal.  It is unfortunate that some doctors are so poorly trained in thyroid treatment that they look at a person's lab while they are on thyroid medicine and say, “See, your lab is normal so now you can stop taking your thyroid!”.  The thyroid gland does not regenerate, start working again or heal unless you have the rare  kind that occurs after childbirth and then resolves after 12 months. Otherwise, taking thyroid is for life, and unlike pellets and supplements, you will feel the symptoms come back right away.    Taking a hypothyroid patient off their thyroid replacement medicine leaves them severely hypothyroid and unable to stay awake, with chronic swelling, low heart rate, low BP, weight gain, severe fatigue and hair loss, and feeling cold all the time. The doctors who do what I describe above and take patients off their medicine should go back to medical school physiology. “Figures often lie, but liars always figure!” –my husband is a lawyer, and he uses this phrase all the time in his arguments. It is true that a medical study can be manipulated to conclude anything you want it to.  A researcher trying to prove something can manipulate the structure of the study, or choice of participants in the study, or just title the article so that it implies something that is the opposite of the true findings, like the NIH did with the Womens Healthcare Initiative in 2002. When I see different results in my office than what the studies tell me, I trust what works for my patients, and double the veracity of the study. Later I am usually happily surprised that the study was deemed inaccurate because it was done wrong, the population was one not in my patient population (like all patients are Asian, and I have very few Asians in my population) or the assumptions of the results were inaccurate.  Using the information that patients give them and determining the best treatment for that individual is the job of a doctor…to read studies critically and compare them to the results seen in their own patient populations, then use what they see with her own eyes to treat their patients. I hope I have encouraged patients who wonder what their pellets or supplements are doing for them after years of successful treatment who might think they will stop because they are “cured”, to think again.    Menopause, Testosterone deficiency and hypothyroidism don't just go away! They are something that must be treated to bring you back to a quality of life, you will have to treat these deficiencies until you die, or have a medical reason you have to stop treatment. Sadly, pellet therapy and nutritional supplementation are not curative if you don't take them, you go back to how you felt before treatment! You might lose years of joy and health by stopping the treatments that make your health and quality of life better. Think it through and talk to your doctor or NP before you make any changes.

Dr. Jennifer Penrose interviews a patient, Tom, a client that did our 8-week weight loss and wellness program. He lost 38 lbs and his A1C went from 8.0 to 7.2. The best news is he has been completely off insulin since Sept 30, 2022. He used to take over-the-counter medication to golf and now he doesn't need it - his joints don't hurt eating this way. He still has 40 lbs to lose so it is not his weight that is the main issue of the joints feeling better. The sugar, the processed foods, the refined carbohydrates (bread and pasta), and beef lead to inflammation. His BMI went from a 47.1 to a 41.7. He is committed to continuing this lifestyle and his main motivation is to never go back on insulin again. He now wants to get off Metformin. Listening to this episode they get a FREE TLS weight loss consult.

The connection between blood sugar regulation, immune health and endocrine function is incredibly strong. This means there is now more and more research coming out on ‘off label' medication use. Today we talk about animal research on metformin use in HT. Research DiscussedJia, X., Zhai, T., Qu, C., Ye, J., Zhao, J., Liu, X., … Qian, Q. (2021). Metformin Reverses Hashimoto's Thyroiditis by Regulating Key Immune Events. Frontiers in Cell and Developmental Biology, 9. doi:10.3389/fcell.2021.685522Holistic Practitioner Growth System Foundations https://learning.naturopathicmentorship.com/courses/holistic-practitioner-growth-system-foundations-jan-2023 Use code: ‘podcast2023' to save $100! Learn More about the Certified Women's Health Practitioner! https://learning.naturopathicmentorship.com/bundles/certified-womens-health-practitioner Stay in touch! Naturopathic Clinical Mentorship Site | https://naturopathicmentorship.com NCM Learning Platform | https://learning.naturopathicmentorship.com Advanced Women's Health website | https://www.advancedwomenshealth.ca/Finally Lose It Book | https://sarahwilsonnd.com/finallyloseitInstagram | https://www.instagram.com/drsarah_nd/ Facebook | https://facebook.com/sarahwilsonnd Live in Ontario? Book an appointment In Person or Virtual! https:...

Like last week, we are going to revisit one of the top two interviews from 2022. This conversation was with my most (personally) anticipated interview, Dr. Sandra Kaufmann. I fell in love with her first anti-aging book from several years ago and then fell in love again when she released her newest book this summer. She is a highly-respected expert in the longevity community and she didn't disappoint in this interview. Enjoy learning from Dr. Kaufmann... The author of one of my all-time favorite books recently released her second book, which was like Christmas coming early for me! Luckily, I had also met her before at an anti-aging conference and we have stayed in touch throughout the years. So I knew I had to Dr. Sandra Kaufmann on The Red Light Report for some amazing conversation about anti-aging and longevity strategies, especially as it relates to supplements and adjuvants —  topics that she is considered a bonafide expert. In her newest book, Aging Solutions, Dr. Kaufmann covers 28 different agents that she has found to be the most efficacious and backed by science, according to her rigorous research. We cover many agents from both of her books along with Dr. Kaufmann's skincare routine and other longevity hacks she as implemented over the years, including red light therapy! Dr. Sandra Kaufmann began her academic career in the field of cellular biology, earning a Master's Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. She has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children's Hospital for 9 years, a nationally recognized center of excellence. Dr. Kaufmann's avid interest in the science of anti-aging begun many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first ever, comprehensive theory of aging. She has now released two books on longevity: The Kaufmann Protocol: Why We Age and How to Stop it, and just recently in 2022, Aging Solutions.   This conversation could have easily gone on for hours and hours, as Dr. Kaufmann is a wealth of knowledge in some of my favorite topics and is fun to listen and learn from. I know you will all enjoy learning from her like I did and, if so, I highly recommend you check out BOTH of her books. They are simply amazing resources of anti-aging/longevity information. As always, light up your health! - Dr. Mike Belkowski & Dr. Sandra Kaufmann discuss the following: Her reasoning for jumping into anti-aging and longevity RAADfest - October 2022 in San Diego Supplements vs. adjuvants How people confuse deficiency with longevity Bioavailability and resveratrol  Bringing natural remedies back into the light The five basic agents of the Panacea Astaxanthin and its benefits for free radical scavenging The blood-brain barrier Nicotinamide and why it's crucially important for longevity Anti-inflammatories for longevity Glycation Eye health and vision Carnosine eyedrops Eye health and red light therapy Goggles vs. no goggles with red light therapy Supplements and adjuvants she is most excited about Spermidine and how it prevents DNA damage The mitochondrial transition permiability pore Fisetin for longevity Senescent cells (zombie cells) Metformin vs. berberine Glycation and how to defeat it How her diet doesn't affect her good lab results Her anti-aging and longevity regiment Skin health UV exposure to the skin Starting treatments earlier vs. later Micronutrient deficiencies and getting older Newfound discoveries - Watch this episode on YouTube - Where to Learn More From & About Dr. Sandra Kaufmann:   Website: KaufmannProtocol.com   Instagram: @KaufmannAntiAging   - Books written by Dr. Sandra Kaufmann:   Aging Solutions (2022)   The Kaufmann Protocol (2017)   - Check out the Kindle version of Red Light Therapy Treatment Protocols eBook, 4th Edition - To learn more about red light therapy and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Stay up-to-date on social media: Instagram YouTube

What's the latest on invasive Group A streptococcal infections?

Host: John Buse, MD, PhD Guest: Jennifer B. Green, MD What does the latest research on glycemia reduction show us about the impact of glucose-lowering medication in combination with metformin on microvascular and cardiovascular outcomes in patients with type 2 diabetes? Dr. John Buse speaks with one of the study's investigators, Dr. Jennifer Green, a Professor of Medicine at Duke University, about this emerging data.

Episode - 147 Health Heroes! Some of you have been requesting an episode on diabetes and since over 80 million people in the U.S. have diabetes I felt it was time to provide a show with some natural solutions.  Dr. Nikki Siso was diagnosed with Type I diabetes when she was 29 years old and after almost a decade of suffering she went back to school and earned her PhD. in Holistic Health & Nutrition. Since then she has improved her quality of life and drastically reduced the amount of insulin she takes on the daily. Since then she has built her practice with a focus to help others with Type 1 and Type 2 diabetes get their lives back. She believes like I do, that you don't have to feel like a prisoner to your blood sugar meter and having to jab yourself with insulin all day. Thank you for listening and please subscribe and share this podcast if you like the content and think it could benefit someone you know. Love & Light -Coach Tim.  To Connect with Dr. Nikki go to: https://www.drnikkisiso.com/   Tim's Favorite, HIGHEST QUALITY Health Product Recommendations: Best Detox & Nutrition Supplements: https://www.chemicalfreebody.com/  Best Infrared Saunas & Healing Lamps: Tim's personal unit - Save $100 CLICK HERE Water Purification/Restructuring System: Book FREE Consult CLICK HERE Best Home Air Purification Unit : Tim's personal unit CLICK HERE Best Non Toxic Home Building Materials: CLICK HERE  See omnystudio.com/listener for privacy information.

Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Colleen and her company Pendulum Life probiotics make unique strands of probiotics that help rebuild the gut lining and prevent leaky gut and help reverse type-2 diabetes. A double-blind randomized control study showed that users taking Pendulum's Glucose Control probiotic had a reduction in A1C by 0.6% and a reduction postprandial glucose spikes by 32.5%. Clearly there is more to weight loss than just calories in and calories out.Go to www.pendulumlife.com to get your probiotics and use the code "HACKED" in checkout for a discount. Timeline2:30 - What's wrong with the probiotic industry4:11 - Why most probiotics don't work5:35 - How Pendulum's probiotic works?12:52 - How Pendulum probiotics affect the brain14:46 - Can I still take Pendulum if I don't have weight issues?17:03 - How Pendulum affects cravings and is GLP agonist19:15 - How long does it take to see the effects22:16 - What happens if you stop taking it?25:32 - An explanation of Pendulums three products28:50 - Metformin versus Pendulum probiotics32:55 - Why butyrate is so important34:20 - New product coming soon with polyphenols35:40 - Why the products can appear pricey

The drug Ozempic is a trending topic lately. Originally designed to help control diabetes, it's been picked up by the media as the latest and greatest off-label fix for weight loss. In fact, my own husband tried this drug - and he's not even a celebrity! So, I wanted to find out: what is this drug, what exactly does it do, and does it actually help people lose weight?   Joining me for this conversation is Lauren Harris-Pincus, a nutrition communication specialist, speaker, spokesperson, and registered dietitian in the New York/New Jersey area for 25 years. With Lauren's help, we explore the molecular nitty gritty of what semaglutide (aka the active ingredient in Ozempic) does in the body, whether the drug Hollywood is infatuated with is actually Ozempic or Wegovy, and overall the world of problems associated with glorifying weight loss drugs as a “silver bullet”. All this and more - stay tuned!   Resources: https://nutritionstarringyou.com/ ---   The Keri Report dissects health and nutrition with a no-nonsense approach.   Nutritionist, yoga teacher, and author of The Small Change Diet Keri Gans delivers her straightforward and sometimes controversial approach to what's current in the health and nutrition world. Her fun and engaging personality will leave you with a wealth of information on need-to-know hot topics for your overall well-being.   To find more information and to join Keri's mailing list, visit her website: https://kerigansny.com/   Instagram/Twitter: @kerigans Facebook Page: @KeriGansNY   This episode was produced by Jess Schmidt. Visit her website at https://www.jessdoespodcasting.com

It's In the News.. a look at the top news stories in the diabetes community over the past seven days. This week, The US FDA gives the green light to Dexcom's G7 CGM, Mark Cuban's Cost Plus Pharmacy puts out a survey all about insulin, new studies looking at teens with type 1 and blood pressure as well as CGM and hospitalizations at the VA and much more! Previous episodes on Dexcom's G7: https://diabetes-connections.com/?s=g7 Check out Stacey's book: The World's Worst Diabetes Mom! Join the Diabetes Connections Facebook Group! Sign up for our newsletter here Episode Transcription Below (or coming soon!) Please visit our Sponsors & Partners - they help make the show possible! *Click here to learn more about OMNIPOD* *Click here to learn more about AFREZZA* *Click here to learn more about DEXCOM* Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and these are the top diabetes stories and headlines of the past seven days. XX In the news is brought to you by T1D Exchange! T1D Exchange is a nonprofit organization dedicated to improving outcomes for the entire T1D population. https://t1dexchange.org/stacey/ XX Our top story is big news.. Dexcom's G7 gets FDA approval. This device with a shorter, half hour warm up time, with the sensor and transmitter all in one piece was approved for people age 2 and up with all types of diabetes. It was approved as an iCGM as expected, which is good news for the automated systems the G6 currently works with.. much more to come of course, we've done a lot of episodes on the features and design of the G7 so I'd urge you to listen to those if you haven't yet and of course we'll follow up with a new episode with Dexcom as soon as they'll talk to me! XX In other news.. Illinois Attorney General files a fraud lawsuit, accusing Eli Lilly, CVS Pharmacy, Novo Nordisk and several other pharmaceutical companies of artificially inflating the cost of insulin by over 1,000% since the late 1990s. The complaint singles out Eli Lilly in particular, noting the price for a dose of its analog insulin Humalog rose by 1,527% between 1997 and 2018. "Remarkably, nothing about these medications has changed," the complaint states. "Today's $350 insulin is the exact same drug defendants originally sold for $20." The suit also notes that 13% of Illinoisans, about 1.3 million people, live with diabetes, making the pharma companies' alleged monopoly scheme a public health threat. There are several other state and class action suits against the insulin makers going through the courts right now. So far none have landed more than a glancing blow. https://www.courthousenews.com/illinois-attorney-general-sues-over-sky-high-insulin-prices/ XX A new contender, though, might be entering the arena. Mark Cuban's Cost Plus Pharmacy put out a tweet this week asking for feedback on adding insulin to their lower-cost inventory. Quote - Insulin users: we are evaluating a future insulin test program and would like your feedback. If we offered a 90-day supply of a fast-acting insulin (up to 12 vials/8 packs of pens) for $170 incl. shipping, what would you think?” There's a feedback form and I'll link that up in the show notes. https://forms.office.com/Pages/ResponsePage.aspx?id=nlWlyavTPES7xglhq5HvDwx1m5bO2mRDq1ekDvUshMtUNUZBM0dDUTA3RVpUOEY1WVNWVDE4U0JTMiQlQCN0PWcu XX People with diabetes who used glucose lowering drugs prior to getting COVID-19 seem to have fewer COVID-19 related adverse outcomes during hospitalization. The mediations have already been shown, albeit in conflicting findings, to have possible benefits regarding morbidity and mortality among patients with diabetes who become infected with COVID-19. These meds include orals like Metformin as well as injectables like sglt2 inhibitors like Jardiance and Invokana GLP-1 agonists like Ozempic and Trulicity. https://www.ajmc.com/view/glucose-lowering-drugs-may-reduce-risk-of-covid-19-related-adverse-events-in-patients-with-diabetes XX New research about opioids and diabetes. This study says people People with diabetes who underwent surgery had a significantly increased rate of prolonged opioid use (POU) compared to people without diabetes who underwent surgery. 56% higher for people with type 2 and more than 200% higher for those with type 1. This was a big, retrospective, observational study of more than 43,000 people who had operations at a single diverse healthcare system in 2008-2019. The researchers say this shows that in a real-world setting healthcare providers are generally not accounting for individual risk factors when prescribing postoperative opioids. https://www.medscape.com/viewarticle/985068 XX Teens with Type 1 diabetes (T1D) who took bromocriptine, a medication used to treat Parkinson's disease and Type 2 diabetes, had lower blood pressure and less stiff arteries after one month of treatment compared to those who did not take the medicine, according to a small study published in Hypertension, an American Heart Association journal. People with type 1 are at higher risk of high blood pressure and those diagnosed with T1D as children have even higher risks for heart disease. Therefore, researchers are interested in ways to slow down the onset of vascular disease in children with T1D. The study's small size is a limitation. However, the researchers note that further research into bromocriptine's impact on vascular health in a greater number of people with Type 1 diabetes is warranted; they are planning larger trials. https://medicalxpress.com/news/2022-12-parkinson-medication-blood-pressure-teens.html XX CVS is facing a fraud charge with a lawsuit accusing them of deceptive fundraising in a campaign it held for the American Diabetes Association. Prior to each customer's transaction, a checkout screen prompts the customer with several options for pre-selected dollar amounts, as well as an opt-out option, allowing donations to the diabetes association. Yet, the plaintiff alleges, CVS did not forward donations to the diabetes association, but instead applied the donations toward a legally binding $10 million obligation CVS made to the diabetes association. In November, Edward L. Powers, a lawyer for CVS, filed a motion to dismiss the case, challenging the plaintiff and his lawyer on their interpretation of the alleged $10 million “debt.” CVS says they agreed to fundraise from customers and turn over the donations to the diabetes association. After more than three years of fundraising, CVS would make up the difference between the cumulative customer donations and $10 million, according to the motion. The group bringing the suit disagrees and says everyone who made a campaign donations” are entitled to damages. https://www.bostonglobe.com/2022/12/05/metro/tweet-draws-attention-lawsuit-accusing-cvs-fundraising-fraud-checkout-cvs-has-filed-motion-dismiss-suit/ XX Wearing a CGM can keep you out of the hospital.. according to a new study focusing on Veterans Affairs clinics in the US. Wearing a CGM was associated with a lower risk for all-cause hospitalization and mortality in adults with type 1 and type 2 diabetes. This was even though the people with type 2 who received CGM were actually unhealthier [than non-CGM users] according to the researchers, who called the mortality reductions, dramatic. During a presentation at the World Congress on Insulin Resistance, this researcher said: “All of this data suggests that we may need to look at these types of outcomes in a much more serious fashion, because there may be some additional benefits that we didn't appreciate. If true, then maybe CGM use may become more like the SGLT2 inhibitors, and we'll start using them in a much more comprehensive way.” https://www.healio.com/news/endocrinology/20221202/cgm-use-lowers-hospitalizations-may-reduce-mortality-in-type-1-and-type-2-diabetes XX Back to the news in a moment but first.. The T1D Exchange Registry is a research study conducted online over time, designed to foster innovation and improve the lives of people with T1D. The platform is open to both adults and children with T1D living in the U.S. Personal information remains confidential and participation is fully voluntary. Once enrolled, participants will complete annual surveys and have the opportunity to sign up for other studies on specific topics related to T1D. The registry aims to improve knowledge of T1D, accelerate the discovery and development of new treatments and technologies, and generate evidence to support policy or insurance changes that help the T1D community. By sharing opinions, experiences and data, patients can help advance meaningful T1D treatment, care and policy. The registry is now available on the T1D Exchange website and is simple to navigate, mobile and user-friendly. For more information or to register, go to www.t1dregistry.org/stacey XX outed by celebrities, raved about by TikTok users, and advertised by med spas, a new class of drugs for treating diabetes and obesity has exploded in popularity for its weight-loss effects, leading to rippling shortages across several of the medications. Amid the surge in demand, Eli Lilly and pharmacies have started to tighten access to the latest of this type of drug, tirzepatide, focusing on giving it to people with type 2 diabetes, the only population it's authorized for so far. But that's left another set of patients scrambling — people with clinical obesity who turned to the medication as one of their few options for treatment. The class of drugs are GLP-1 receptor agonists, which mimic the effects of a hormone that can help people feel full. Within this group, Novo Nordisk's obesity drug Wegovy and diabetes drug Ozempic have been in short supply for months due to manufacturing issues and increased demand. Lilly's diabetes medication Trulicity has also been in tight supply, according to the drugmaker. That leaves tirzepatide, sold under the name Mounjaro. Lilly said in a statement that the drug is currently not in shortage, but that the company is continuing to monitor availability of competitor therapies and “supply with a focus on access for people with type 2 diabetes.” Related: Patients seeking novel weight loss drugs find a ‘wild west' of online prescribers In October, Lilly made changes to a discount program for the drug, now requiring people to attest they have type 2 diabetes. The coupons allowed patients to get the drug for $25 a month when it would otherwise cost about $1,000. Some pharmacies are also now checking if people have a diabetes diagnosis before filling prescriptions. https://www.statnews.com/2022/12/07/eli-lilly-tightens-access-tirzepatide-mounjaro-diabetes-obesity/ XX XX On the podcast next week.. yale lacrosse player Bri Carrasquillo was diagnosed just after her freshman year. Now she's part of Dexcom U – a new program for college athletes with type 1. Last week's show was One Drop is making a CGM? We'll talk to CEO Jeff Dachis about that. Listen wherever you get your podcasts That's In the News for this week.. if you like it, please share it! Thanks for joining me! See you back here soon.

A new research paper was published in Aging (listed as “Aging (Albany NY)” by MEDLINE/PubMed and “Aging-US” by Web of Science) Volume 14, Issue 22, entitled, “The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study.” Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lowers delirium risk, as well as long-term mortality. In the current retrospective cohort study, researchers Takehiko Yamanashi, Zoe-Ella EM Anderson, Manisha Modukuri, Gloria Chang, Tammy Tran, Pedro S. Marra, Nadia E. Wahba, Kaitlyn J. Crutchley, Eleanor J. Sullivan, Sydney S. Jellison, Katie R. Comp, Cade C. Akers, Alissa A. Meyer, Sangil Lee, Masaaki Iwata, Hyunkeun R. Cho, Eri Shinozaki, and Gen Shinozaki from Stanford University School of Medicine, University of Iowa Carver College of Medicine, University of Iowa College of Public Health, and Tottori University Faculty of Medicine analyzed 1,404 previously recruited subjects. The relationship between metformin use and delirium, and the relationship between metformin use and 3-year mortality were investigated. “Thus, in this report we aimed to investigate the relationship between DM [diabetes mellitus] and delirium risk with a focus on the influence from metformin. We hypothesized that history of metformin use is associated with lower risk for delirium. We were also interested in testing if history of metformin use can alter one of the most important patient outcomes, mortality.” 242 subjects were categorized into a type 2 diabetes mellitus (DM)-without-metformin group, and 264 subjects were categorized into a DM-with-metformin group. Prevalence of delirium was 36.0% in the DM-without-metformin group, and 29.2% in the DM-with-metformin group. A history of metformin use reduced the risk of delirium in patients with DM (OR, 0.50 [95% CI, 0.32 to 0.79]) after controlling for confounding factors. The 3-year mortality in the DM-without-metformin group (survival rate, 0.595 [95% CI, 0.512 to 0.669]) was higher than in the DM-with-metformin group (survival rate, 0.695 [95% CI, 0.604 to 0.770]) (p=0.035). A history of metformin use decreased the risk of 3-year mortality after adjustment for confounding factors (HR, 0.69 [95% CI, 0.48 to 0.98]). The researchers concluded that metformin use may lower the risk of delirium and mortality in DM patients. “In this report, we showed the potential benefit of metformin in decreasing the risk of delirium and mortality in DM subjects.” DOI: https://doi.org/10.18632/aging.204393 Corresponding Author: Gen Shinozaki - gens@stanford.edu Keywords: delirium, metformin, diabetes mellitus, mortality, aging About Aging-US: Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at www.Aging-US.com​​ and connect with us: SoundCloud – https://soundcloud.com/Aging-Us Facebook – https://www.facebook.com/AgingUS/ Twitter – https://twitter.com/AgingJrnl Instagram – https://www.instagram.com/agingjrnl/ YouTube – https://www.youtube.com/agingus​ LinkedIn – https://www.linkedin.com/company/aging/ Reddit – https://www.reddit.com/user/AgingUS Pinterest – https://www.pinterest.com/AgingUS/ For media inquiries, please contact media@impactjournals.com.

For more information on this topic or to schedule a consultation please visit us at http://WhatIsHashimotos.com So we're going to talk about Hashimoto's and PCOS today. Apparently there's a lot of people who are interested in that topic. And I would say with good reason. I don't think there's a week that goes by that I don't do a consult with a female patient who has polycystic ovarian syndrome and Hashimoto's and PCOS are fairly closely connected. And I don't remember what the percentages are. It might be something like 30% of females who have Hashimoto's get PCOS. Might be 40%. It's up there. And of course, polycystic ovarian syndrome, of course, maybe you know this already, is responsible for up to 50% of infertility in this country. So the connections are kind of clear, but they're not always that easy to explain, because when you have Hashimoto's, you have these vicious cycles going on with virtually every organ system and biochemical process in your body because the thyroid affects every single thing that there is. And the real cause of autoimmune thyroid disease, I'm sorry. The real cause of polycystic ovarian syndrome is prediabetes. And I'm shocked at this point in time how few people coming in here really know that. So prediabetes, the infamous prediabetes of which nobody gets very excited over and you go to the doctor and go, ah, your pre diabetic. Maybe somebody will give you Metformin. Maybe somebody will tell you, change your diet, but most of them just go, eh, just watch your diet and exercise a little bit. And then we'll wait until you get to diabetes type two, and then we'll give you the real drugs. Okay. In the meantime, that mechanism creates chemistry that causes your ovaries, there's enzymes in the ovaries and these lyase enzymes stop working properly. And the next thing you know, you may not be making enough estrogen, but you start making too much testosterone, thus the hair on your face. And the fact that you want to get angry and choke your husband and all those types of things. So I have more thorough presentations on polycystic ovarian syndrome online, but that's really the basis of it. Now, what can cause that? There's so many things that can cause that. Stress can cause that, but thyroid can cause that because thyroid affects so many different functions that can set you off and create insulin resistance. So that's really where it's at. Okay. Like for example, relative to autoimmune thyroid disease. http://powerhealthtalk.com http://drmartinrutherford.com Martin P. Rutherford, DC 1175 Harvard Way Reno, NV 89502 775 329-4402 http://powerhealthreno.com https://goo.gl/maps/P73T34mNB4xcZXXBA

Many of you have asked me to break down the pros and cons of Metformin vs. Berberine. Jump in here as I address each for Type 2 Diabetes, weight loss and overall longevity. Many biohackers out there are using both Metformin and Berberine for reduction of cancer, for brain protection from Alzheimer's, Parkinson's, Dementia, neurological diseases of aging and other various diseases of aging. Here we go one by one... Research studies mentioned in episode: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351883/ https://ijhs.shmu.ac.ir/index.php/ijhs/article/view/610 https://www.researchgate.net/publication/341607228_The_Aerobic_Training_and_Berberine_Chloride_Intervention_on_Pancreatic_Tissue_Antioxidant_Enzymes_and_Lipid_Peroxidation_in_Type_1_Diabetic_Rats Shop ALL of Dr. Amie's Fixxr Supplements: Fixxrsupps.com Subscribe to my Text Club: Text DRAMIE to 8332631365 LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman Book a free discovery call: https://dramiehornaman.com/pages/book-a-call FREE DOWNLOADS… Are My Labs Optimal? What Do I Do? Don't know where to start...don't know which labs are useful? And what to do when you get your results? Heal Your Hashi with Keto a 7 Day Challenge: 7 daily tasks to implement if you are looking for that nutritional change, and a challenge that can help get you on the road to healthier, dietary choices!  CONNECT WITH ME ON SOCIAL MEDIA: Join my exclusive Facebook Group, Dr. Amie…The Thyroid Fixer®...Love Your Mirror, for a Community of HOPE and Support in your thyroid journey. https://www.facebook.com/groups/dramie/ Like me on Facebook: Amie Hornaman Nutrition and Functional Medicine Subscribe on Youtube: Dr. Amie Hornaman Follow me on Instagram: @dramiehornaman

From Andres's show notes:"Despite what we want to believe, cardiovascular disease does not only start once we are in our 50s and 60s. As we welcome Kevin Bass back to the Know Your Physio podcast, we hear his opinions on cholesterol, the medications to take, and opinions on collected long-term genetic studies. We don't hold back on having a controversial conversation around starting the reduction of low-density lipoprotein (LDL) cholesterol in your mid to late 20s, the role of genetics in our predisposition to cardiovascular health issues, and how we need to look at things from an environmental, health, and nutrition perspective. Kevin tells us about his preferences and opinions on the different interventions for LDL cholesterol reduction and how he aims to (one day in the future) create a risk reduction calculator that will look at and create a risk-benefit profile. Plus, Kevin discusses his feelings toward Andrew Huberman, consulting medical professionals, and some signs of when it may be time to start looking at taking prescription cholesterol medication!Key Points From This Episode:People in the fitness industry who are pissing Kevin off.Different calculations people can do to determine their risk of cardiovascular disease.Interventions for LDL cholesterol (including prescription medication) and their side effects. A look at how to reduce LDL cholesterol.Kevin's opinions on Andrew Huberman.Unpacking cardiovascular disease considering your genetics and potential preventative measures. Why Kevin believes people 25 and older can start cholesterol medication.Where Kevin gets the long-term genetic studies data from.Analyzing and interpreting data on cardiovascular disease to create a relative risk reduction.Why Kevin wants to create his own risk reduction calculator and risk-benefit profile.Signs people should start looking for when deciding to take cholesterol medication.Questions to potentially ask your doctor to help you identify your cardiovascular risk (and why they may be unlikely to prescribe).A look at the purpose and benefits of statins, metformin, and rapamycin.Links Mentioned in Today's Episode:The Diet WarsKevin Bass on TwitterThe Kevin Bass Show YouTubeDebunking Andrew HubermanBiOptimizersAndrés PreschelKnow Your Physio Podcast"===Like, comment, subscribe.For more, find me at:PODCAST The Kevin Bass ShowYOUTUBE https://www.youtube.com/user/kbassphiladelphiaSUBREDDIT www.reddit.com/r/kevinbassWEBSITE http://thedietwars.comTWITTER https://twitter.com/kevinnbass/https://twitter.com/healthmisinfo/INSTAGRAM https://instagram.com/kevinnbass/TIKTOK https://tiktok.com/@kevinnbassAnd above all, please donate to support what I do:PATREON https://patreon.com/kevinnbass/DONATE https://thedietwars.com/support-me/

Unser Leben verlängern. Das ist etwas, woran die Forschung mit Hochdruck arbeitet. Gesucht werden Wirkstoffen, die wie ein Jungbrunnen wirken. Andere Konzepte zielen darauf ab, unsere Zellen zu verjüngen. Vieles ist Zukunftsmusik. Einiges geht schon jetzt. // Alle Quellen und weitere Spezials findest du hier: https://www.quarks.de/daily-quarks-spezial/ Von Michael Lange.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Gerald Shulman is a Professor of Medicine, Cellular & Molecular Physiology, and the Director of the Diabetes Research Center at Yale. His pioneering work on the use of advanced technologies to analyze metabolic flux within cells has greatly contributed to the understanding of insulin resistance and type 2 diabetes. In this episode, Gerald clarifies what insulin resistance means as it relates to the muscle and the liver, and the evolutionary reason for its existence. He goes into depth on mechanisms that lead to and resolve insulin resistance, like the role of diet, exercise, and pharmacological agents. As a bonus, Gerald concludes with insights into Metformin's mechanism of action and its suitability as a longevity agent. We discuss: Gerald's background and interest in metabolism and insulin resistance (2:30); Insulin resistance as a root cause of chronic disease (6:30); How Gerald uses NMR to see inside cells (10:00); Defining and diagnosing insulin resistance and type 2 diabetes (17:15); The role of lipids in insulin resistance (29:15); Confirmation of glucose transport as the root problem in lipid-induced insulin resistance (38:15); The role of exercise in protecting against insulin resistance and fatty liver (48:00); Insulin resistance in the liver (1:05:00); The evolutionary explanation for insulin resistance—an important tool for surviving starvation (1:15:15); The critical role of gluconeogenesis, and how it's regulated by insulin (1:20:30); Inflammation and body fat as contributing factors to insulin resistance (1:30:15); Treatment approaches for fatty liver and insulin resistance, and an exciting new pharmacological approach (1:39:15); Metformin's mechanism of action and its suitability as a longevity agent (1:56:15); and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

A rare MD at the cutting edge of the longevity field, Dr. Barzilai heads the Institute for Longevity Research at Einstein. We cover his unique contributions, especially the currently buzzy topic of metformin, as well as his work on the genetic luck of centenarians.

Welcome back to The Down to Earth PCOS Nutrition Podcast! Today I am outlining why Inositol (known most commonly as the brand name Ovasitol) may vastly improve your insulin-related PCOS symptoms, improve fertility and restore a natural menstrual cycle. I'll be backing up these claims with scientific evidence and giving you some ‘best practices' for taking inositol with PCOS! While there are actually 9 types of Inositol, I am talking specifically about Myo-Inositol and D-Chiro Inositol and how they, with the correct dosage, can improve insulin resistance, lower the risk for heart disease, improve hair loss (or hair growth) and aid in weight loss among other benefits. When it comes to supplementation, it's important to consult your doctor for personalized recommendations. Please keep in mind that this episode is purely for educational purposes, and my goal is to equip you to make the best personal decision about supplementation. With that said, should you choose to start taking Inositol, I am sharing some general best practices to consider when picking the right product as well as recommended use for it. What You'll Learn on this Podcast Episode: The 2 types of Inositol that aid in PCOS management The specific reason Myo- and D-Chiro Inositol improve PCOS symptoms Results others have got through supplementing with Inositol (based on scientific studies) The correct ratio of Inositol to better chances of seeing success Inositol vs. Metformin and other medications The main reasons you may not be seeing results if you've already tried inositol My general recommendations and best practices for taking Inositol. Helpful PCOS Links: Join the Reset Your PCOS waitlist! Follow me on Instagram

Do you take any medications? If not, do you ever worry you'll have to go on them some day because of your health habits? Many people worry no longer dieting will lead to health concerns that require medications. This idea is a MAJOR roadblock to progressing in your Intuitive Eating work. How do you stop letting this common fear hold you back from becoming an Intuitive Eater? In this episode Melissa talks to fellow Dietitian Kristie Messerli about why even the IDEA of going on medication comes with so much guilt, fear, and shame and how to get past it. As a Certified Diabetes Educator, Kristie shares how to use informed decision making when it comes to deciding (with your doctor!) how medication might fit into your health care plan. Though these examples center on Kristie's experience with diabetes medication, this episode is a must-listen for anyone trying to understand more about Health at Every Size and how the philosophy considers medication as a tool for health. We discuss: Common fears people experience before going on medications What different diabetes medications do in the body - including pros and cons Can you go from pre-diabetes to normal range without medication? What kinds of things should you be considering before you go on medication? What is informed decision making? How can you practice it in your everyday life? Of course - Kristie and I are Dietitians, but we're not YOUR Dietitian so please consult with your doctor before making any changes to your lifestyle behaviors or medication usage. Our opinions are our own and do not serve as a substitute for medical advice. Are you new to the pod? Been here a while? Your 5 star review and feedback means the world! Thank you for supporting the pod so we can help others become the first in the family to break the diet cycle, just like we are! Episode Resources: Follow Kristie on Instagram @type2diabetes.nutritionist Check out Kristie's post on informed decision making and Metformin here: https://www.instagram.com/p/ChAIrcirF-F/ Join the Break the Diet Cycle Podcast Community: @break.the.diet.pod Connect with Melissa on Instagram: @no.more.guilt This episode was sponsored by No More Guilt with Melissa Landry Want coaching support for a life of No More Guilt? Right now, Melissa is only accepting 1:1 clients. You can apply at www.melissalandrynutrition.com or message her on Instagram @no.more.guilt to learn more. Group coaching programs are currently on hold, but Melissa may entertain bringing back groups in time for 2023 for the right set of women really ready to do this work! If you are interested in staying in the loop of any upcoming groups, you can put your name on the waitlist here: https://mailchi.mp/5d3986bd6987/nomoreguiltgroups --- Send in a voice message: https://anchor.fm/breakthedietcycle/message

CJASN Editor-in-Chief Rajnish Mehrotra interviews 2022 CJASN Trainee of the Year winner Bart J. Kramers on his article, "Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD."

Videos: Did Julian Assange's lawyers just EXPOSE this CIA scheme? Redacted with Natali and Clayton Morris (3:23 to 6:46) EXCLUSIVE: UNDERTAKER EXPLAINS “MYSTERIOUS” CLOTTING PHENOMENON! | Louder with Crowder (8:17 – 26:00)   Green tea and resveratrol reduce Alzheimer's plaques in lab tests Tufts University, November 2, 2022 Tufts researchers are working to understand what might slow progression of Alzheimer's disease. They have tested 21 different compounds in Alzheimer's-afflicted neural cells in the lab, measuring the compounds' effect on the growth of sticky beta amyloid plaques. These plaques develop in the brains of people with Alzheimer's. The researchers found that two common compounds—green tea catechins and resveratrol, found in red wine and other foods—reduced the formation of plaques in those neural cells. And they did so with few or no side effects. The researchers reported their findings in the journal Free Radical Biology and Medicine. Some of the 21 compounds tested reduced the disease progression by acting as anti-viral agents—slowing Alzheimer's induced by the herpes virus. But finding a compound “that could diminish the plaques regardless of the virus component would be ideal, because that would show that regardless of the cause of Alzheimer's, you might still see some kind of improvement,” says Dana Cairns, GBS12. Cairns is a research associate in the Kaplan Lab in the School of Engineering and led the research. The initial screen found five compounds had “really robust prevention of these plaques,” she says. In addition to the green tea compounds and resveratrol, they found curcumin from turmeric, the diabetic medication Metformin, and a compound called citicoline prevented plaques from forming and did not have anti-viral effects. “We hoped to find compounds that would be harmless and show some level of efficacy,” she said. Green tea compounds and resveratrol met that standard. “We got lucky that some of these showed some pretty strong efficacy,” Cairns said. “In the case of these compounds that passed the screening, they had virtually no plaques visible after about a week.” The discovery is significant because there is no cure for Alzheimer's or a way to prevent its progression, aside from several potential drugs developed by pharmaceutical companies that are still in trials, Cairns says. Compounds like these two that show some efficacy and are known to be safe and easily accessible could be taken as a supplement or consumed as part of one's diet, she adds. High fiber, yogurt diet associated with lower lung cancer risk Vanderbilt University Medical School, October 28, 2022 A diet high in fiber and yogurt is associated with a reduced risk for lung cancer, according to a study by Vanderbilt University Medical Center researchers published in JAMA Oncology. The benefits of a diet high in fiber and yogurt have already been established for cardiovascular disease and gastrointestinal cancer. The new findings based on an analysis of data from studies involving 1.4 million adults in the United States, Europe and Asia suggest this diet may also protect against lung cancer. Participants were divided into five groups, according to the amount of fiber and yogurt they consumed. Those with the highest yogurt and fiber consumption had a 33% reduced lung cancer risk as compared to the group who did not consume yogurt and consumed the least amount of fiber. “This inverse association was robust, consistently seen across current, past and never smokers, as well as men, women and individuals with different backgrounds,” she added. Shu said the health benefits may be rooted in their prebiotic (nondigestible food that promotes growth of beneficial microorganisms in the intestines) and probiotic properties. The properties may independently or synergistically modulate gut microbiota in a beneficial way. Yoga Practice Beneficial to Patients With COPD All India Institute of Medical Sciences Oct. 28, 2022 Patients with COPD who practice yoga can improve their lung function, according to a study by researchers at the All India Institute of Medical Sciences, Department of Pulmonary Medicine and Sleep Disorders. The study found that lung function, shortness of breath, and inflammation all showed significant improvement after patients completed 12 weeks of training. An estimated 24 million Americans may have COPD, which includes chronic bronchitis, emphysema, or both. Patients with COPD have trouble pushing used air out of their lungs, making it difficult to take in healthy new air. Although there is no cure for COPD, a patient's quality of life can be improved by controlling symptoms, such as shortness of breath. The study included 29 stable patients with COPD who received yoga training in a format that included the use of physical postures (asanas), breathing techniques (pranayama), cleansing techniques, (kriyas), meditation, and a relaxation technique (shavasan) for 1 hour, twice a week, for 4 weeks. Following the 4-week period, patients were trained for 1 hour every 2 weeks, with the remaining sessions completed at home. Patients were evaluated on assessment of lung function, breathing, quality of life, and inflammation status. A repeat assessment was done at the end of the 12-week training session. All parameters showed significant improvement at the end of the 12-week period. “We found that yoga can be a simple, cost-effective method that can help improve quality of life in patients with COPD,” stated Dr. Guleria. Iron proposed as cause of heart failure in many heart attack patients Indiana University School of Medicine, November 2 2022. A study published in Nature Communications revealed the discovery of a cause for chronic heart failure that occurs in approximately half of the people who experience a heart attack. “For the first time, we have identified a root cause of chronic heart failure following a heart attack,” lead researcher Rohan Dharmakumar of Indiana University School of Medicine's Cardiovascular Institute announced. Using large animal models, the research team found that in heart attacks in which bleeding within the heart muscle occurs upon restoration of circulation, scar tissue is gradually replaced by fat. The inability of fat to effectively propel blood from the heart can lead to heart failure in survivors of this type of heart attack. “Using noninvasive imaging, histology and molecular biology techniques, and various other technologies, we have shown that iron from red blood cells is what drives this process,” Dr Dharmakumar reported. “When we removed the iron, we reduced the amount of fat in the heart muscle. This finding establishes a pathway for clinical investigations to remedy or mitigate the effects associated with iron in hemorrhagic myocardial infarction patients.” The finding led to a clinical trial to determine the effect of iron chelation therapy to remove excess iron in patients with hemorrhagic heart attack. “While advances across populations have made survival after a heart attack possible for most, too many survivors suffer long-term complications like heart failure,” Indiana University's Cardiovascular Institute physician director Subha Raman, MD noted. “Dr Dharmakumar's breakthrough science illuminates who is at risk and why and points to an effective way to prevent these complications.” DHEA supplementation associated with improved sexual function in women Center for Human Reproduction (New York), October 6, 2022 A report published in the journal Endocrine revealed improvements in sexual function among older premenopausal women who supplemented with the hormone dehydroepiandrosterone (DHEA). In their introduction to the article, authors Vitaly A. Kushnir of the Center for Human Reproduction in New York and colleagues describe their use of DHEA in the treatment of infertile women who had low levels of androgen hormones. “In the process of treating thousands of so-affected infertile women, we noticed that many spontaneously reported improvements in libido, sexual desire and, sometimes, even pain status, leading to the paradoxical situation of women refusing to discontinue DHEA supplementation once they conceived,” they remarked. “When we, in a review of the literature, were unable to find a study that investigated the effectiveness of DHEA on female sexuality in older premenopausal women, this study was developed.” The study included 50 infertile premenopausal women whose age averaged 41 years. The participants supplemented with oral DHEA for a minimum of six weeks prior to starting any other fertility treatments. Serum androgen hormone levels, including DHEA and testosterone, were shown to increase following DHEA supplementation. In comparison with pretreatment scores, FSFI index scores improved by 7%, including a 17% increase in desire, a 12% increase in arousal, and an 8% increase in lubrication. However, among women whose scores were among the lowest 25% of the group, total FSFI scores increased by 34%, which included a 40% increase in desire, a 46% increase in arousal, and a 33% increase in lubrication. Women in this group also experienced a 54% increase in orgasm, greater satisfaction, and less pain in comparison with pretreatment values. Trauma during childhood triples the risk of suffering a serious mental disorder in adulthood, study finds Hospital del Mar Medical Research Institute (Spain), November 2, 2022 A study led by researchers at the Hospital del Mar Medical Research Institute links psychological trauma in childhood with an increased risk of developing some kind of mental disorder years later. Suffering psychological trauma during childhood significantly increases the risk of developing a mental disorder in adulthood. Specifically, as much as three times, according to a recent study, published in the journal European Archives of Psychiatry and Clinical Neuroscience. The study analyses the fourteen reviews and meta-analyses published to date in specialized journals on this issue, and is the first to take into account the full range of existing mental disorders. In total, the studies analyzed incorporate more than 93,000 cases, revealing a direct link between suffering psychological trauma at a pediatric age and the risk of developing a mental pathology later in life. “It is the strongest evidence to date that psychological trauma really is a risk factor for suffering a mental disorder later on,” says Dr. Benedikt Amann, lead author of the study The most common childhood traumas are emotional, physical and sexual abuse, as well as emotional or physical neglect and bullying, although there are many others. Suffering one of these situations damages the brain, causing physical as well as psychological consequences in the form of various disorders. In the case of emotional abuse, the most frequent trauma is associated with the most prevalent disorder in the population, that of anxiety. But there is also a relationship between childhood trauma and other pathologies, such as psychosis, which is linked to all traumas, obsessive-compulsive disorder or bipolar disorder. The risk of suffering from borderline personality disorder increases up to fifteen times in the case of having experienced trauma during childhood. Trauma in adulthood is also associated with a four-fold increase in the risk of a later mental disorder. The researchers point out, however, that there is less evidence for this type of pathology.

This is a re-posting of Episode 54 due to audio problems with the original posting. We all know how important diet and exercise are to weight loss and maintenance, but what about anti-obesity medications? How efficient are they? Host Aaron Lohr speaks with Michael Weintraub, MD, clinical fellow in endocrinology, diabetes, and metabolism at New York-Presbyterian Hospital/Weill Cornell Medical Center. Dr. Weintraub and colleagues presented in an oral session during the Endocrine Society's annual meeting. The abstract is titled "Long-term Weight Loss Maintenance with Obesity Pharmacotherapy: a 5-Year Retrospective Study." For more information, including helpful links and other episodes, visit our website at https://www.endocrine.org/podcast.

Download the cheat: https://bit.ly/50-meds  View the lesson: https://bit.ly/MetforminGlucophageNursingConsiderations    Generic Name metformin Trade Name Glucophage Indication management of Type II DM, PCOS Action decreases glucose production in the liver, decreases absorption, increases cellular insulin sensitivity Therapeutic Class Antidiabetic Pharmacologic Class Biguanide Nursing Considerations • do not use with renal dysfunction, metabolic acidosis • may cause diarrhea, nausea, vomiting, lactic acidosis • monitor patient closely for ketoacidosis and lactic acidosis, discontinue medication immediately if acidotic • may cause metallic taste • instruct patient that medication does not cure diabetes

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Liraglutide probably the best second drug to prevent cardiovascular events in patients with T2DM who take metformin '

Do you find yourself struggling to lose weight, despite diet and exercise?   It might be time to look into leptin resistance.   On this episode of The Hormone Prescription, Dr. Bindiya Gandhi joins us to discuss this little-known hormone and how it could be the key to unlocking midlife weight loss. Dr. Gandhi shares her expert insights on leptin resistance, how it develops, and what you can do to overcome it. If you're looking for answers to your weight loss struggles, this is the episode for you!   Dr. Bindiya Gandhi is double board certified physician in Family Medicine and Integrative and Holistic Medicine. She is Atlanta's Weight Loss doctor and by helping you uncover and tame leptin resistance can turn even the most unsuccessful dieter into a success.   She is a media expert and has been featured in The Daily Mail, MindbodyGreen, PopSugar, Clean Plated, Well + Good and more.   She completed her family medicine training from Georgia Regents University/Medical College of Georgia June 2014. She completed her undergraduate training at the University of Georgia with Bachelors of Science in Biology and Psychology in 2004 and her Doctor of Medicine at American University of Antigua College of Medicine in 2010. She completed an Integrative medicine fellowship at the University of Arizona with Dr. Andrew Weil in 2016. She also completed Functional Medicine Training with the Institute of Functional Medicine in 2017.   Her interests include integrative, holistic and functional medicine, women's health, preventative medicine, international medicine and health care reform. Shes also a certified yoga instructor and reiki master. She used to practice emergency medicine as well. Dr. Bindiya is a media expert and contributor to numerous sites including The Daily Mail, MindbodyGreen, PopSugar, Clean Plated, Well + Good and more! When she's not working or writing you can find her in the kitchen cooking, doing yoga or enjoying time with her family & 3 girls   In this episode, you'll learn:   -What leptin resistance is and how it affects weight loss -How to tell if you're leptin resistant -Tips for overcoming leptin resistance -And more!   So tune in and learn how you can finally start losing weight, even if you've been struggling for years.   (00:00): Dr. Bindiya says, If you never try, you will never know and don't underestimate your worth. What does this mean when it comes to your health at midlife? Stay tuned and find out.   (00:14):So the big question is, how do women over 40 like us keep weight off, have great energy, balance our hormones in our moods, feel sexy and confident, and master midlife? If you're like most of us, you are not getting the answers you need and remain confused and pretty hopeless to ever feel like yourself Again. As an ob gyn, I had to discover for myself the truth about what creates our rock solid metabolism, lasting weight loss, and supercharged energy after 40, in order to lose a hundred pounds and fix my fatigue. Now I'm on a mission. This podcast is designed to share the natural tools you need for impactful results and to give you clarity on the answers to your midlife metabolism challenges. Join me for tangible, natural strategies to crush the hormone imbalances you are facing and help you get unstuck from the sidelines of life. My name is Dr. Kyrin Dunston. Welcome to The Hormone Prescription Podcast.   (01:07): Hi everybody. Welcome back to another episode of the Hormone Prescription with Dr. Kyrin. Thank you so much for joining me today, we're gonna have fun talking about an aspect of weight loss resistance that you might not have heard of and that has to do with leptin. Don't worry if you don't know what it is. We're gonna dive into it, me and Dr. Binda and let you know so you'll have a full understanding and you'll get some ideas and knowledge and support and inspiration. And after all, that's what we're here for. So she will give you a big dose of that. I'll tell you a little bit about her and we will get started. You're gonna love her because she's not only knowledgeable, she is board certified in family medicine as well as integrative and holistic medicine. She studied with Andrew while who is amazing if you know anything about him.   (02:01): And she completed functional medicine training with the Institute of Functional Medicine in 2017. She's also a media expert and she's been featured in the Daily Mail, Mind Body, green Pop, Sugar, Clean Plated, Well and good and many others. Mostly she's Atlanta's a weight loss doctor, but she works with people remotely all over the country and by she can help you uncover and team and resistance and she can turn even the most unsuccessful dietary into a successful one. And she's here to tell you how and how the missing ingredient is leptin. Welcome, Dr. Binda Gandhi, thank you so much for having me today. Super excited to talk to you about leptin resistance. It's something that we really haven't talked, I don't think at all about on the podcast, and it's super important for women at midlife who are trying to lose weight. So I'm excited to dive into this topic. You know, for me, everything's about hormones and this is one that I have neglected to discuss. So I know a lot of people who are regular listeners are like, Yay, Dr. Karen, finally time, you're talking about leptin resistance. So let's get into it. But I wanna start by having you share with everyone how you honed in on leptin as being the biggest block for women at midlife to lose weight.   (03:21): Oh, you know, such a great question. You know, first of all, leptin is a hormone that is fairly a newer hormone, right? Not many people talk about it. You know, you can go to your endocrinologist and they're not even gonna wanna test this hormone. So just a little background about leptin, you know, it's a hormone that is actually produced by your fat cells and it's important because it communicates with your brain. It's basically our satiety hormone. And this hormone basically tells us if we're full or not. And this hormone is actually impacted by so many other hormones that you probably talk about already, like your thyroid, your estrogen, your progesterone, your insulin. So it's very important to kind of understand what's going on with this homo hormone individually, but how it's also being impacted by the other hormones. So this is why I love talking about it, and I really got into this because when I first started helping patients, a lot of people would come to me because they were struggling to get pregnant and they were having fertility issues. And I started noticing a link between leptin and fertility and then started doing some research and realized, hold up. There's more to the leptin story than just how it impacts fertility. It's also impacting not just our weight, it's impacting so many different aspects of our bodies. And this is why I'm so glad we're talking about this today cuz it's such an important hormone and people need to know about it.   (04:46): It is, and thank you for backing up because some people are like, Le left, what? We've never heard of it. And so we really should start with what is leptin? So thank you for explaining that. It's your satiety hormone and how does it interact with other hormones. So I talk all the time, we talk on the podcast, the Hormone Prescription podcast about what I call the six main metabolic driving hormones, which include your three sex hormones, estrogen, progesterone, testosterone, your thyroid, your cortisol, your insulin, your D H E A. And then there's leftin. And we probably should touch on Grillin too. Yes. Because some people we do touch on melatonin sometimes, but not as being one of the key drivers. But lein is the satiety hormone. Thank you for explaining that. And where does it come from in the body where, how does your body make it? How is it used? How does it work?   (05:41): Mm-Hmm. . Great, great question. So it's produced by our fat cells, right? Essentially. And it communicates with our brain and it basically tells us if we're full or not, right after a meal, we should be getting a message from our brain saying, You've eaten enough, you're full, you don't need to eat anymore. That's essentially what's happening with leptin, right? So it tells us when we're full, where it's sister hormone, I'm gonna bring up grillin is the hunger hormone. This is what stimulates your appetite. And it kind of lets you know if you are hungry, right? So leptin on the other hand, tells you if you're full, grin tells you if you're hungry. Now they work in opposite directions and they work together, but also differently at the same time. Right? When we're hungry, grin is high and we're not satisfied. So lectin is low and the opposite happens when we're full and we're we're satisfied.   (06:35): Grin actually ends up being low and leptin is high. So they work, you know, kind of against each other. Not in a bad way, but like with each other, but like their opposites. So it's really important because Gorlin is actually produced by the stomach of the GI tract, and leptin is produced in the hypothalamus, which is part of the brain. So that's just kind of a little bit about the two hormones and how they work. But it's essential to kind of understand background of it because then you can understand how it works with the other hormones. Kind of like the ones you mentioned, thyroid stress hormones, your cortisol hormones, insulin. So it really does impact so many other things. Leptin is actually metabolized in the liver, right? That's, we know this is where our sex hormones are, are metabolized, right? This is where insulin is metabolized. So this is where our t3, three T3 is metabolized, right? So it's really kind of important how it works with the other hormones and where   (07:34): Great point. So let's dive into that. I know there's some people who are thinking, well, let me see. She said when you're full, your, your leptin goes up. So can I just take some leptin and feel like I'm full all the time? But I gotta ask you that first, cuz I know I'm calling it out. I know my people and I know some people are thinking that right now. So if you can address that, and then let's dive into after that, what are all the things that leap an impact?   (08:01): Yeah, so let's talk, I mean, there are some tips and tricks we can do to kind of keep your body feeling full, right? Like we can definitely talk about, which I'm sure people have mentioned before, have heard before, like for example, drinking water before you eat your dinner or your lunch kind of like starts keeping you full and feeling a little bit more satiated. Eating a lot more fiber, keeps you a lot more satiated, right? So your body feels full there. So there's things that will do that. There is no medication on the market that will keep you full. There are medications on the market that decrease your appetite and there are medications on the market that can improve your leptin and we can talk about that a little bit later. However, there is no prescription FDA anything approved on the market that will directly impact your leptin to make you full earlier, if that makes sense.   (08:50): ? Yeah. Okay. All right. So now that we've got that out of the way, you mentioned about leftin being metabolized in the liver and some of the other hormones that are handled by the liver, a lot of them mm-hmm. . So how does Leftin interact with these other hormones in your body in general?   (09:07): Yeah, so we'll start off with thyroid, cuz I feel like so many women at all ages of life have a thyroid issue, right? Whether it's Hashimotos, just hypothyroidism, hyperthyroidism, whether it's overactive, underactive, unfortunately it is, it is a common problem. So when I look at the thyroid and when I'm, what I'm specifically looking at is I'm actually looking at t3, reverse t3, free t3, total t3, because that gives me a different picture. All right? So I'm gonna get a little technical. So guys, bear with me. Okay? When we talk about our thyroid metabolism, and I'm talking about, I'm looking at your t3 s your T3 free T3 s are impacted by many things. One is stress, okay? Chronic stress, like the pandemic or whatever chronic life changes are happening, right? So chronic stress. And the other thing that is impacting your T3 metabolism is a lot of times if we've been on restrictive diets, okay?   (10:09): So the link between leptin and our T3 metabolism happens When we've been on these restrictive diets for long term, most people, Dr. Karen, have been dieting, especially females have been dieting since their teens, whether they realize it or not. And unfortunately, our culture is all about yo-yo dieting, right? Many of us have tried, including myself, we've all been guilty of different diets to see what works for us, right? So we've been, we've tried slim fast, we've tried the special K diet, and I'm speaking for myself. I've, I'm pretty sure we've tried everything in the book. Right now it's keto, paleo, this, that, like, I don't even know the names of what's been out there, Low fat phase, whatever, right? So because about yoyo dieting, that has messed up our thyroid metabolism. And that's also one of the reasons why we have become leptin resistant, okay?   (11:01): Because of the dysregulation in our metabolism and the dysregulation of our body. So when our body thinks we are starving, when our body thinks that when we have cut calories, essentially, you know, we're trying to do that because the old adage was you have to, you have to starve yourself and you have to over exercise, and that's the only way you're going to lose weight. Well, now we know that's inaccurate, right? Because when we were doing all of those diets and those things, what we were essentially doing is messing up our communication with our brain and our bodies and our, and our fat cells. And this is why we would lose weight initially in the first week. And then we would hit a weight loss stall because the leptin communication started getting dysregulated and disrupting. And that's why we, we couldn't lose weight anymore. That's why diets work short term and then we're like starving and we're like, Oh my God, I need to eat everything in the book. Right? That's a little bit of what's happening right now, The what's happening. Okay,   (12:00): Got   (12:00): It. Because of all the long term havoc on our metabolism, and because we've been kind of, and this diet craze for many, many years, our thyroid metabolism has also changed. And this is why thyroid impacts lectin.   (12:14): Okay? Yeah. Very close relationship there. And I'm wondering, you mentioned leptin resistance. Can you tell everybody what that is? And then the next question they're gonna wanna know is, how do I know if I have that? So let's talk about what is leptin resistance?   (12:28): Yeah, love, love, love this question. So leptin resistance is basically when there's that miscommunication happening between your fat cells and your brain, this is probably the reason why your body is not getting the memo or your brain is not getting the memo that you're full. So maybe you're overeating, right? Or maybe eating a larger portions, like you just can't control your appetite kind of thing, right? The other thing that's happening is when you're eating, you don't feel full and an hour later you're wanting to eat again. You're like, Oh, I'm hungry. I need to, I need something else to eat. Or you're constantly snacking. There's definitely some telltale signs, and this is why, guys, I have you take my free, you know, 11 question quiz. It's at dr binda md.com/quiz. You just answer these questions and it'll kind of, it'll kind of help you identify, are you potentially left in resistance?   (13:19): Are you left in sensitive or left and clear, right? Because it's kind of important to understand, do you have some of these symptoms? Majority of us probably have some of these symptoms. We're craving the sugars and the carbs all the time. We have high triglycerides, we have maybe elevated blood pressure or whatever it is. And some of that stuff is all correlated and connected to leptin resistance. So go ahead, take the quiz, let me know. But that's the first thing. The other thing I would say is working closely with ideally a functional medicine provider, like I mentioned, your primary care doctor unfortunately, is not going to know what to do with this information or even be able to help you with this. A functional medicine practitioner is probably able to kind of guide you and say, Yes, I'm happy to check this number and I'm, I know how I can help you with this.   (14:01): Even an endocrinologist, like I mentioned earlier, who manages hormones, they don't, number one, check this lectin level. And number two, if they check it, they're not gonna really help you or give you the right protocol either. And I, I wish they would, but again, this just, this is a newer hormone and, and not much known is known about it. So if like when I, with my patients, I automatically do a blood test and I'm testing their leptin number. If your leptin blood level is above 11, then I can definitively say, You know what? Your definitely in resistance. If it's below three, you're lept in, you're on the other end of the spectrum. So, and if you're between the perfect number is actually between seven and 10. That's ideally where we'd like every patient to be. Now not everybody's going to reach those perfect numbers, and that's okay. It's, it's everybody's fine. But what I like to do is track this number. So a lot of patients will come to me and they've got leptin numbers in their fifties. I've got patients that have leptin numbers in their hundreds. So our job is to kind of bring that number down to as close as possible to 11. And that's how we do things.   (15:09): Okay? So blood test for leptin, and thank you for giving some idea about ranges so people can know. And then definitely check out the quiz. We'll have the link in the show notes. So if you're driving, please don't try to write that down. Just wait till you get parked and you can click the link in the show notes. All right. So I do wanna touch back on other things that leptin interacts bit and interacts with. But while we're on the topic, say somebody does have a lectin of 50 and they come to you, what is your general approach to start improving their lectin sensitivity?   (15:47): As you know, as a functional medicine practitioner, my job is to kind of understand and to get to the root cause, right? So we can start identifying what is going on. I can, I can look at it and say, Yep, leftin is off, but the next question is, what else is off? You know, I'm also looking at all the other hormones and I'm trying to see how they're interacting with wettin. I'm also analyzing what their hemoglobin a1c, their fasting insulin is to kind of see do they have some insulin resistance as well? Do they have some inflammation? Because once I can identify some of these things, then I can hone in on a specific protocol to bring this number significantly down. So it is a very, it is a very holistic 360, you know, lifestyle, diet supplement approach. I mean, it's, it's, it's very comprehensive to, to what we're doing, right?   (16:35): Sometimes we're, I, I would definitely wanna bring this up and, and sorry if I'm going all over the place, but sometimes people think that, you know, they need to be intermittent fasting and they, they think they need to be starving themselves and that actually can make their left and number worse, right? I often, I often see this when people are like, Oh, I decided to intermittent fast and then I see their leftin number go from like 20 to 26. So there's different things that, that start happening, but we definitely want to pay attention to their other hormones and then putting them on a program and protocol that's specific to them. And so sometimes that means, I'm telling you, you're actually going to eat more food. And people are like, What? What will you have to do? What? And I'm like, Yeah, you know, all this time that you've been intermittent fasting, it's actually slowed down your metabolism and has been one of the reasons why there's a miscommunication with your body because your body thinks you're starving. So it's holding onto extra weight and calories that you give it, right? So we, we start kind of like refeeding a little bit.   (17:31): Yes, I love that we have to eat more, not less to lose weight and to boost our metabolism. And I love that you mentioned intermittent fasting and leptin, because intermittent fasting is all the rage right now. And I see so many women who are intermittent fasting and initially they, they do lose weight, but then they hit a plateau, like you described, like with most diet and , intermittent fasting is a great tool to use for specific purposes at specific times for specific people. It is a tool. Hammer is not always the right tool all the time for everyone. And I think that everyone thinks that intermittent fasting is the greatest activity for everyone. So I want everyone to hear what Dr. Bindi is saying, cuz you've heard me say this. It's not just me, but she's saying that it can affect lectin resistance. So what are some reasons why, and how does intermittent fasting impact lectin? And what are some other negative impacts that intermittent fasting can have?   (18:35): Oh yeah. Okay. I'm so glad you brought this out because it really is something that I, I think we need to again, educate a little bit more about. So again, like you said, there are some people that do really, really well with intermittent fasting, different phases of your life. You know, intermittent fasting unfortunately can impact your hormones. So in a good way, in a bad way, right? And yes, there's so many great benefits of it, but for example, if you're cycling, if you're a woman who's currently cycling and you are trying to have a baby or that kind of thing, intermittent fasting can actually be one of the reasons why you are having trouble getting pregnant, right? The reason is, when it comes to intermittent fasting, there's different, first of all, there's different types of intermittent fasting, right? There's the fasting mimicking diet and there's all these different protocols, right?   (19:21): 24 hour fast, 36 hour fast. Like, and these things can be very extreme for the body. When we're intermittent fasting. Short term, you'll definitely see results. But when it starts being long term and now you're doing 16, eight fast every single day and you are not taking breaks, you're, you don't have the metabolic flexibility that's going on, what ends up happening is your body thinks you're starving, right? When your body thinks you're starving is not sure when it's gonna get fed again, it's like, whoa, what's happening? When am I gonna get food again? Oh, not until tomorrow at 2:00 PM okay, I'm going to hold onto every single calorie. I'm gonna hold onto everything. So the thing that the tool that was working for you before, the hammer that was now helping you, you know, put that nail in place is not, what ends up happening is the body starts holding onto the fat and holding onto every calorie.   (20:11): So now you become even sensitive to every time you eat and you feel like, Oh, I feel like I'm gaining weight or I feel like I'm doing the same thing, but I I weigh the same, Like I should be lose continuing to lose weight. No, cuz you're, you're, you've essentially just changed your metabolism and I've actually slowed it down. And that's what that, that's essentially what's happening here. The other thing that that really helps with that's happening with intermittent fasting is you're causing yourself to have not only a slow down metabolism, you're causing yourself to have other hormonal imbalances and your body's just getting confused, right? Your T3 and your free T3 start getting affected and your thyroid starts kind of slowing down. So, so many different things are happening at the same time and not always a good thing.   (20:56): Yeah. And it affects your cortisol stress hormone. Most people don't realize that,   (21:00): Oh yeah, I forgot about that. Yes. Oh my goodness. Yeah. And this is why I always say, you know, it is a hormetic stressor, but more importantly to Dr. Karen is when you're in a stressful situation, like if you are taking care of elderly parents or you're taking care of young kids, or you just started a new business, or you just got fired from your job, whatever it is, whatever life stresses you're going through divorce, that's not the right time to start intermittent fasting because your body's already in a stressed state. Now, add on intermittent fasting, you're asking for cortisol and adrenal disruption.   (21:33): All right? So we had to get that out of the way. And what other interactions do you think it's important for people to know about when it comes to leptin in their body? What other organ systems, hormones does it interact with?   (21:49): So we kind of touched upon it already. Mm-Hmm. , thyroid for short adrenals are the other ones, right? So it impacts your adrenal hormones. And again when you're in a very stressed state, the body thinks that, you know, exercise, let's talk about exercise. Exercise can, can be considered or etic state, but it can also be a very stressful state if you're doing high intensity exercise all the time, right? So if you're doing some of those things all the time, this is gonna impact your adrenal hormones and then impacts, which then impacts your leptin levels, right? So that's, that's another hormone that it impacts. And the other thing is that we need to pay attention to is, is just making sure that we've got really good stress management skills under our belt. You know, I tell people all this all the time. We live in a very stressful state.   (22:36): You know, we can't live in a bubble. I wish we could all somehow be Buddhist monks and just be like zend out all the time. It just doesn't happen with our lifestyles, right? Especially as females, because we take care of so many people and often we forget to take care of ourselves, right? And all that stress really impacts all our, our hormones, our adrenals, our cortisols, everything. And so understanding some of these basic things and having the right tools in place can really start not only helping those numbers and those levels get better, but in comprehension it, it'll also start decreasing your leptin resistance as well.   (23:14): Yes. This is so important. You mentioned self care in there. So I have to say I'm at a yoga retreat in Massachusetts this month and working and attending the retreat and there's so much support for your self care here and just classes and education and experiential experiences and you know, I think that I know about self-care and then I come to a place like this and they take it to a whole other level. And it really is just highlighting for me, India, how much we lack self care, even in my daily life where I think I'm doing a good job and I come to a place like this. And I notice that in some of the yoga classes that are restorative or again, slower gentle yoga classes, I'm so impatient. My brain is constantly going, Oh my gosh, they're going so slow, I'm going to lose my mind. , . And it really is highlighting for me that even though I think I'm slowing down and taking time and doing the thing, really I'm just doing it at home. So I could check it off the list and I wanna share this. Yes. Because I know there are people listening who are doing this and they think they're doing self care and like me, they're probably not really doing self care. .   (24:39): No, you're absolutely right. And a lot of it is you nailed it is, you know, we have dual checklists and we're like, Oh, the doctor told me to do self-care, so I'm going to get a massage and oh, I check that off. That doesn't count guys. , it doesn't count. It doesn't count,   (24:58): Right? And so I think foundationally every episode of the podcast, I'm just gonna be harping on everyone or just giving an invitation to really explore what is self care? What is adequate self care for you? So I want to invite everybody listening to really start leaning into that question. And you will get answers when you lean into the questions. Dr. Binda shared a few quotes that she loved with me before we started the episode, and I wanna weave some of them through this episode because they're wonderful. The first is don't underestimate your worth, which you are worthy of having the best that love and life have to offer. And that starts with your self care. And another quote is, if you never try, you will never know. And so I wanna ask everybody to close your eyes if you're not driving or operating heavy machinery, and just take a few deep breaths in and out and ask yourself about something that you've considered or are considering embarking on and you're nervous about, Should I, shouldn't I?   (26:12): Or you hear me talking about leaning into this question about self care and you're thinking, Oh Karen, I don't have time for that, But you're worth it, number one. And if you tried to lean into this question, what benefits could you reap? I mean, I've really regained a connection with myself that I, I hadn't even realized I was missing by being at this retreat. So I don't wanna proselytize too much. I just wanna give an invitation. What if you, you tried and you found out that something could be the real needle mover. What if you hear Dr. Bindi talking about lectin resistance and you're like, Oh, I think I'll reach out and take her quiz and get tested and find out if that's my problem. And I'm wondering if you could share Bindi, because you just have a newborn who's 16 weeks old, you already have two other children, you have a full time medical practice. What are key components of your self care practices that really help you stay healthy?   (27:14): You know what, I started this routine actually when I was in medical school and I, you know, I tried to be as consistent as I can with it. Obviously sometimes having kids, you can't do all the things you used to be able to do. But every morning, Dr. Karen, I start off by meditating. And so at this point I've been doing it for almost, I don't know, 15, almost close to 20 years. And it is what gets me going in the morning. It's how I start my day and it is very, very important for me. So I started off doing five minutes a day and I started off like with not really knowing what I was doing. And I would listen to YouTube videos at the time. And now I, I've progressed, I personally like guided meditations cuz it helps me keep focused sometimes, kind of like you, I I have the monkey mind and so if I try to meditate by myself, my brain will kind of get into, Oh, these are the things you need to do today.   (28:09): You know what I mean? And if I have some sort of audio in the background, it helps me stay focused. So that is one thing that I think is, that's my thing. That's what I do. That's what that, when I do that in the morning, I am grounded and I feel like I can handle it. And especially since I have two toddlers, my mornings can quickly go in any, any direction. So I need to be able to keep my cool and stay grounded. And I will tell you the days I do not meditate, like because I wake up late or because because my baby, you know, I, I don't get enough sleep and I'm like rushing or whatever. My temper is definitely shortened the days I don't meditate.   (28:48): Yes, I notice when I don't meditate, my day is more challenging, I will say. Yeah. Yep. And I invite anybody who hasn't tried it, who's just been suspect. There's so much research backing how meditation improves your health. You're including your hormones starting with your yes. So I encourage it. And I'm wondering before we wrap up, if you could share a story of a patient who might come to mind. I know of all the thousands of patients I've treated over the years, there's some that really stand out as being the poster children for certain hormonal imbalances. And I'm wondering if you have someone who really had been struggling, maybe searching for answers and she came to you and wow, it all ended up being about lectin that you could share with everyone.   (29:36): I treat both males and females in our practice and one patient really sticks out to me. She actually was 64 female, 64 years old and was actually diabetic at the time. Came to see me, it was I think last November, October, November, and just struggling. She had been to the con through the conventional route, struggling with her weight, struggling with everything. She was kind of frustrated by the system, had tried diets on herself in the past, nothing worked. Or if it worked kind of like many, many people, they wouldn't stick. She'd lose 15 pounds, then only gained 20 pounds back, right? So it was that yoyo effect. So I started working with her about November of last year and I put her on a very extensive protocol, you know, adjusting her diet and things started moving in the right direction. We started decreasing inflammation. We started seeing, now she's no longer on, she was actually on Metformin and Genuvia at the time, which her diabetic medications now she's not even on any diabetic medications at all.   (30:39): So her A1C went from a 6.8 to now 5.7. So she's still kind of in that pre-diabetic phase, but she's not requiring medication, which is much like, that's an improvement. So, you know, we definitely adjusted a lot of things with her. Her biggest thing that I wanna kinda shed light upon that really made a big difference. Dr. Karen was actually helping her with stress management. So she was 64 years old and was having issues with about being about to retire, having a little stress without with that. And then her daughter ended up having a baby. So she was kind of like feeling a little overwhelmed because she was helping her daughter with the newborn. So there's all these different stressors in her life going on at the same time. But once we were able to hone in and kind of help her with her mindset and help her kind of find the right type of lifestyle modifications and diet that was perfect for her. The weight started coming off, inflammation started decreasing. Insulin resistance obviously has improved significantly and she's feeling much better. The other thing I will add that we did do for her, which I think really helps balance her a lot too, is we did start her on some hormone replacement therapy. And again, that was something that she was kind of afraid to do before and that also kind of helped stabilize her.   (31:59): Awesome. Well it sounds like she embraced this other quote that you shared with me today can always be the first step to something great by reaching out to you and doing something different and really digging deep to find the root causes. So I'm super glad she did because everybody listening may or may not know how severe a hemoglobin A1C of 6.8 is. I mean, that's pretty drastic. And getting it down to 5.7 doesn't happen in most diabetics. They just are put on medications and told, you're gonna be on this forever and you're gonna be at risk for kidney failure, liver failure, heart attack, dementia. Exactly. Amputation, all these things. And I had a professor when I went through my fellowship who used to say that, that that was basically the mainstream prescription. You know, congratulations, you have diabetes, you get a team jersey, you'll have it forever.   (32:52): You'll be on these medications and here's what you'll have to look forward to. And that's not the case. Mm-Hmm. . So whether you're diabetic or not, today can always be the first step to something. Great. And thank you Dr. Bindi, for sharing this wonderful information. Focusing on left in, we're gonna have the, the link to the quiz, which you've told everyone about in the show notes, while also have a link to your free download fives to improve your weight loss resistance. Yes. And any last word you wanna share with everybody about lectin and weight loss and metabolism.   (33:27): You know, one thing I will say is, guys, an anybody listening today, one thing that I really wanna encourage is many of you have probably listening and you're like, You know what, I'm gonna try doing this on my own. I think I have this, I'm gonna do this on my own. And I promise work closely with a good integrative and functional medicine provider, doctor, because I promise when you work with someone who is able to learn about you and can personalize it, you're gonna get the best result. And so stop trying to do things on your own. .   (33:57): I mean, you know, I love that you said that. It's so true cuz people will hear this and be like, searching on the internet, Where can I get a leptin blood test checked? And I mean, people, I see people do this all the time and then they get the information and then now what? Now what? I never get the results that they could have. Yeah. And you know, I, I have this one coach and he always tells me he's a business coach. He says, Kirin, do you know the difference between wealthy people and not wealthy people? And I say, No, what? And he says, Wealthy people understand that time is their most valuable asset, not money. And so they are willing to invest to gain more time and get the fast route. Yeah. And get the best help. And not wealthy people think they can do everything themselves, but yes, who has that time kind of time, right?   (34:45): Yeah. So important guys, if you're listening today and you're suspecting that you have a leptin issue, by all means reach out to me, you know, have a virtual practice. I'm happy to help out. But even if it's not me, you know, just work with someone because essentially you cannot do these things on your own. A lot of you guys have tried for so long and there's a reason why you've unfortunately failed. So just trust and find the right practitioner, and I promise you will get the best results of your life.   (35:12): Those are very wise words. Thank you so much for joining me today, Dr. Bindiya.   (35:18): Thank you so much, Dr. Karen. This was a pleasure and   (35:21): Thank you all for joining me for another episode of The Hormone Prescription with Dr. Kyrin. Hopefully you have learned something today that you can put into action to improve your health. I want this to be informative, hopefully a little bit entertaining. But if you don't take action, nothing changes. And today really can always be the first step to something great like Dr. Bindi said. So what steps will you take? Please reach out to me on social media, on Facebook and Instagram and let me know and let me know about the results that you are getting. Thanks so much for joining me. I will see you next week for our next episode of the Hormone Prescription. Until then, peace, love, and hormones y'all.   (36:05): Thank you so much for listening. I know that incredible vitality occurs for women over 40 when we learn to speak hormone and balance these vital regulators to create the health and the life that we deserve. If you're enjoying this podcast, I'd love it if you give me a review and subscribe. It really does help this podcast out so much. You can visit the hormone prescription.com where we have some free gifts for you, and you can sign up to have a hormone evaluation with me on the podcast to gain clarity into your personal situation. Until next time, remember, take small steps each day to balance your hormones and watch the wonderful changes in your health that begin to unfold for you. Talk to you soon.   ► Are you a leptin-resistant? Find out in Dr. Bindiya's Quiz. CLICK HERE.   ► 5 Ways To Improve Your Weight Loss Resistance Free Download - CLICK HERE.   ► Feeling tired? Can't seem to lose weight, no matter how hard you try? It might be time to check your hormones.   Most people don't even know that their hormones could be the culprit behind their problems. But at Her Hormone Club, we specialize in hormone testing and treatment. We can help you figure out what's going on with your hormones and get you back on track.   We offer advanced hormone testing and treatment from Board Certified Practitioners, so you can feel confident that you're getting the best possible care. Plus, our convenient online consultation process makes it easy to get started.   Try Her Hormone Club for 30 days and see how it can help you feel better than before.   CLICK HERE to sign up.  

It's “In the News…” a look at the top diabetes stories and headlines of the past seven days. This week: Michigan joins California in exploring producing and distributing insulin made in-state, new study looks at why girls have a harder time with T1D than boys, weekly basal insulin moves forward, Dexcom puts G7 in wider release (but not yet in the US) and more! Check out Stacey's book: The World's Worst Diabetes Mom! Join the Diabetes Connections Facebook Group! Sign up for our newsletter here Episode Transcription Below (or coming soon!) Please visit our Sponsors & Partners - they help make the show possible! *Click here to learn more about OMNIPOD* *Click here to learn more about AFREZZA* *Click here to learn more about DEXCOM* Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and these are the top diabetes stories and headlines of the past seven days. XX In the news is brought to you by T1D Exchange! T1D Exchange is a nonprofit organization dedicated to improving outcomes for the entire T1D population. https://t1dexchange.org/stacey/ XX Michigan following California when it comes to exploring making and distributing insulin. Governor Gretchen Whitmer signed an executive directive this week to establish a Michigan-based insulin manufacturing facility, and facilitate the development, in conjunction with a partner or partners, of a low-cost insulin product for distribution in Michigan. Whitmer already announced a plan to cap insulin costs in her State of the State address in January. https://michiganadvance.com/blog/whitmer-signs-directive-seeking-to-lower-insulin-costs-wins-bipartisan-praise/ XX Novo Nordisk plans to move forward with its once a week insulin icodec. Recent studies show it worked as well or better than daily basal insulin, reducing A1C after 52 weeks. Novo Nordisk's ONWARDS program for once-weekly insulin icodec comprises six phase 3a global clinical trials, including a trial with RWE involving more than 4,000 adults with type 1 or type 2 diabetes. It is expected that Novo Nordisk will file for regulatory approval of the once-weekly insulin icodec in the first half of 2023 in the US, the EU, and in China. There is a separate and additional study for people with type 1 – looking at weekly insulin icodec wth mealtime insulin. That's expected to conclude in about six months. https://pharmaphorum.com/news/novo-nordisk-achieve-headline-results-with-icodec-insulin/ XX Big new study shows that girls tend to have more serious issues with type 1 diabetes than boys. This is physical, quantifiable stuff, including higher blood sugar levels, weight issues, and higher cholesterol. This was a review of 90 previous studies at Amsterdam University Medical Centers. that women and girls have typically not received as much attention as study subjects as men. These researchers say more study is needed including finding ways to help doctors treat girls with type I diabetes differently than boys https://www.healthline.com/health-news/why-type-1-diabetes-can-be-tougher-on-girls-than-boys XX Alarming new study says that cases of type 1 worldwide could double by 2040. Tracking has improved in recent years, but Type 1 diabetes is underrepresented. In addition, because many countries don't collect Type 1 diabetes data, the numbers have historically skewed toward North America and Europe. About 175,000 people worldwide died because of Type 1 diabetes in 2021, they believe, and 63 to 70 percent of the deaths in those under age 25 occurred because the disease wasn't diagnosed. This study is in the Lancet Diabetes and Endocrinology https://www.washingtonpost.com/health/2022/10/03/diabetes-type-one-surge/ XX Big new study looking at which drugs paired with Metformin work the best for type 2. The trial was conducted at 36 study centers nationwide with more than 5000 people. Three groups took metformin plus a medicine that increased insulin levels: sitagliptin or Januvia, liraglutide or Victoza, or glimepiride or Amaryl. The fourth group took metformin and a long acting insulin. After about five years of follow-up, the researchers found that all four drugs improved blood glucose levels when added to metformin. But those taking metformin plus liraglutide or the long-acting insulin achieved and maintained their target blood levels for the longest time. The effects of treatment did not differ with age, sex, race, or ethnicity. However, none of the combinations overwhelmingly outperformed the others. https://www.nih.gov/news-events/nih-research-matters/popular-diabetes-drugs-compared-large-trial XX Dexcom's G7 is getting a wider rollout: the United Kingdom, Ireland, Germany, Austria and Hong Kong, with launches in New Zealand and South Africa in the coming weeks. I'll link up the promotional video.. no news yet from the US FDA on when the G7 will be approved in the US. I am talking to Dexcom's Senior Director of Global Product Design for Tuesday's podcast episode. https://www.youtube.com/watch?v=dYqNUf0paAU XX Tandem's t:connect mobile app is now compatible with the latest iOS operating system on version 2.3 of the t:connect mobile app. Until this update, you could lose the mobile bolus if you updated your phone. Tandem also added a new iPhone and nine new android devices to their compatibility list. We'll link that up in the show notes. : https://www.tandemdiabetes.com/.../device-compatibility XX Back to the news in a moment but first.. The T1D Exchange Registry is a research study conducted online over time, designed to foster innovation and improve the lives of people with T1D. The platform is open to both adults and children with T1D living in the U.S. Personal information remains confidential and participation is fully voluntary. Once enrolled, participants will complete annual surveys and have the opportunity to sign up for other studies on specific topics related to T1D. The registry aims to improve knowledge of T1D, accelerate the discovery and development of new treatments and technologies, and generate evidence to support policy or insurance changes that help the T1D community. By sharing opinions, experiences and data, patients can help advance meaningful T1D treatment, care and policy. The registry is now available on the T1D Exchange website and is simple to navigate, mobile and user-friendly. For more information or to register, go to www.t1dregistry.org/stacey XX The College Diabetes Network announces a name change – they'll now be known as the Diabetes Link. The groups says this new name reflects a commitment to expand support to the larger young adult diabetes community, whatever the type of diabetes they live with and whether they're in school or in the workforce. Currently, there are 3 million young adults (ages 17-30) living with diabetes in the U.S. and that number continues to increase every day. The Diabetes Link is the only national organization that focuses specifically on people in their teens and twenties, in recognition that this time of their lives is full of enough change and challenges without a chronic disease added to the mix. XX And finally, another zoo animal with a CGM. Tiana is a lemur in New Zeleand. The zoo's education officer, has diabetes and recommended the Dexcom for the lemur. Interestingly, they aren't using insulin here, but rather a hypoglycemia medication and are altering the lemur's diet. Apparently lemurs are prone to something more like type 2 diabetes due to some iron issues or if they eat too much sugar, but Tiana's case more resembles type 1. https://www.stuff.co.nz/national/130016440/meet-tiana-the-diabetic-lemur-with-a-glucose-monitor-stuck-to-her-back#:~:text=Hamilton%20Zoo%20resident%20lemur%2C%20Tiana,with%20diabetes%20in%20the%20zoo.&text=Zoo%20vet%20Tori%20Turner%20says,Hamilton%20has%20joined%20the%20club. XX On the podcast next week.. Dexcom's Senior Director of Global Product Design – Very We'll talk about what goes into designing a comletley new product like the G7. He lives with type 1 himself. This past episode is all about how diabetes communities around the world stayed connected during the early days of the pandemic, Listen wherever you get your podcasts Hey for you parents, we've got a webinar on Halloween, link in the show notes and on my social media. That's In the News for this week.. if you like it, please share it! Thanks for joining me! See you back here soon.

Bodybuilding Podcast Oct 3rd Dan Bodybuilder From Thailand ULTIMATE GUIDE TO ROIDS 109pg E-BOOK BY DAN THE BODYBUILDER FROM THAILAND. PUTTING THE TRUTH OUT. DARK SECRETS OF BODYBUILDING LINK FOR IMMEDIATE DOWNLOAD - https://www.e-junkie.com/i/yovb?card 0:00 Back in Asia 2:45 Best Bodybuilding Friendly Countries for Vacation 5:00 Andriol Test Undecanoate Capsules 6:00 Stereotypical Effects of Testosterone are from the Propionate Version 6:50 "Shedding Hair" from gear 8:35 MK-677 Blood Sugar - Diabetes 10:30 Metformin anti diabetic effect 14:00 HGH adding a super charger to the steroids, but it needs to be dressed up. 18:39 Why does the speed of delivery of Testosterone Propionate change its effects in comparison to long acting testosterone 20:30 someone wants to use Lantus insulin as their base hormone and never come off. Insulin and Visceral Fat 24:09 Deca Heart Toxic - Cardiovascular Disease and Bodybuilding 31:00 Resting Heart Rate in Bodybuilders - My Observations 35:00 Diuretics Antidote 36:00 Asking Doctors for what you want 38:00 Perfect Estrogen Levels 44:00 Aspirin for bodybuilders 46:30 Ratios vs. Dosages that Work 49:00 How to Cut successfully if you "Can't Lose Weight" This Podcast is for entertainment and conversational purposes only. Serious Injury and Death can occur from utilizing chemical performance enhancement. This author does not support the use of illegal performance enhancing drugs. If any substances mentioned in this video are illegal in your country do not use them. The purpose of this podcast is not to glorify the use of PED's but to bring to light the reality of what athletes are doing privately. Consult a doctor before beginning any exercise or supplement routine. Do not take anything mentioned in this video as advice. It is simply conversation, not advice.

Episode 150: Peeling Back The Layers of PCOS Polycystic Ovarian Syndrome affects 6-12% of women of childbearing age. According to the revised criteria, PCOS is identified via amenorrhea, polycystic ovaries on an ultrasound, or a combination of hirsutism and hyperandrogenism. Women with PCOS often see elevated LH to FSH, high free Testosterone, low SHBG, high fasted insulin or cortisol dysregulation on serum lab work. Because PCOS is a mix of so many different systemic dysfunctions, it can be hard to treat. Medical solutions include Metformin, birth control, spironolactone, and finasteride. Together we discuss the pathophysiology of PCOS and how we approach it from natural coaching angles. www.theexcellencecartel.com

SHR # 2926:: How to Proliferate Akkermansia Muciniphila - Dr. J. Matt Andry, MD - I first heard about Akkermansia in 2016 when my fiend and personal physician, Dr. Matt Andry, spoke at the A4M world congress in Las Vegas Nevada. Alisa and I attended the event specifically to hear his lecture because, at the time, it was one of the effects of Metformin. Metformin was moving into the spotlight as a senolytic drug and Dr. Andry was on the bleeding edge of this research. He was lecturing physicians about how Metformin may owe many of its attributed to Akkermansia Fast forward 7 years and now Akkermansia is a much sought after probiotic supplement, and eating diets rich in foods that promote Akkermansia promise to be beneficial in correcting obesity, diabetes, inflammation, and metabolic disorders. - View and download all shows at https://superhumanradio.net - Visit us on Instagram: @superhumanradio - Support SHR - https://superhumanradio.net/make-a-donation

Episode 2187 - On this Saturday's show, Vinnie Tortorich welcomes "Lucy X" back for the third update on her online health coaching job, and they discuss the status of the company, the benefits of a keto diet, how you won't get fooled again by pharma ads, and more. https://vinnietortorich.com/2022/09/wont-get-fooled-again-epsiode-2187 PLEASE SUPPORT OUR SPONSORS WON'T GET FOOLED AGAIN Vinnie welcomes Lucy X back for a third show and asks her to quickly summarize the program that her company advises. (3:30) Lucy gives some insider scoop about the program and what is currently going on in the company. (7:00) Vinnie tells Lucy how she is doing a great service to people by letting them know about how the company works. (13:30) Lucy tells Vinnie what else is new going on with the company. Vinnie asks Lucy to recap her own journey to NSNG®. (18:48) Lucy also tells how recently her son was diagnosed with an issue that requires him to be on a ketogenic diet. (22:00) She mentions that had she not heard Vinnie on Mike Rowe's podcast, the wouldn't be believing the doctor's advice. Vinnie reviews his recent conversation with Dr. Ben Bikman (Episode 2176) regarding brain health. (23:30) Vinnie mentions some of the stories he has exposed in his documentaries about doctors making abysmal recommendations to parents for what the ketogenic diet itself has improved. This leads to a conversation about Metformin and other medications, and they analyze the legal language during commercials that protect the pharma companies, but basically also admit they aren't really effective. (28:50) Big Pharma is now making drugs for your drugs! (48:32) Vinnie explains two drugs that saved his life. (49:38) They chat more about some of the side effects mentioned in the commercials. [the_ad id="20253"] PURCHASE BEYOND IMPOSSIBLE The documentary launched on January 11! Order it TODAY! This is Vinnie's third documentary in just over three years. Get it now on Apple TV (iTunes) and/or Amazon Video! Link to the film on Apple TV (iTunes):  Then, Share this link with friends, too! It's also now available on Amazon (the USA only for now)!    Visit my new Documentaries HQ to find my films everywhere: REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: Then, please share my fact-based, health-focused documentary series with your friends and family. The more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: Then, please share my fact-based, health-focused documentary series with your friends and family. The more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter!  

IN THIS EPISODE OF THE HUMAN UPGRADE™... you'll learn that while yes, testosterone fuels energy and performance, it's not the be-all and end-all solution for men's health woes. A systems biology approach considers many other aspects and provides a broader perspective about what's going on with you.This conversation features board-certified urologist Tracy Gapin, M.D., one of the 8th Annual Biohacking Conference keynote speakers. He'll be on the main stage in Beverly Hills in September. He joins this special preview episode to discuss new ways for men to improve their health and performance. He uses epigenetic coaching, hormones, peptide therapy, biometric monitoring, and unique nutrition and lifestyle interventions.“Testosterone levels over the last 30 years are down by about 30 percent,” Dr. Tracy says. “Free testosterone, which is the bioavailable, active hormone testosterone is actually down over 45%. This is really important. We're not just talking about sex and muscle, we're talking about a man's life and cardiovascular health and cognitive function. The culprit can be debated, but without question, one of the biggest ones in my mind is endocrine disruptors. Toxins, chemicals in our environment that are clearly crushing men's health, clearly crushing testosterone. It's the food we eat, it's the water we drink, it's the personal care products. It's ubiquitous, it's almost everywhere and it's getting worse.”In his book, “Male 2.0™: Cracking the Code to Limitless Health and Vitality,” he says medical school, residency training and even a two-decade career in urology and surgery specialties didn't teach him how to get to root causes of men's issues and solve them. He had a health crash of his own at 42. Since neither he nor his doctor had good answers, he went on a quest of discovery and change. He founded the Gapin Institute for High Performance Medicine and created the proprietary N1 Performance Health Program to go beyond conventional options.This conversation goes even further into what creates epigenetic signals that affect the function and expression of your genes. You'll learn, too, that your mindset, stress and environment—and how you do or don't control those things—have everything to do with your energy and focus. If you're aiming for higher performance, Dr. Tracy suggests a trifecta that makes sleep a priority, builds resilience to stress, and creates consistent behaviors with intention.More about Dr. Tracy Gapin: He's a member of the American Academy of Anti-Aging, the Age Management Medical Group, and the International Peptide Society. He spent almost 20 years at a urology practice in Sarasota, Fla., where he specialized in robotic surgery, minimally invasive treatment for prostate cancer, and men's health.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: TEXT “HEALTH” to 2 6 7 8 6 to get three bonus gifts.***WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Vascular System Protection: https://arterosil.com/DAVE/, save up to 45% on a 3-pack to protect your blood vessels from vulnerable plaqueMattress Temperature Tech: https://www.eightsleep.com/dave, use code dave to save $250 on the Pod ProKickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any planSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.