Podcasts about Metformin

Medical professor at Duquesne University Dr. Marguerite Duane and FACTS About Fertility executive director join Trending with Timmerie: Episode Guide PCOS name changed to Polyendocrine Metabolic Ovarian Syndrome (PMOS)(2:00) Use progesterone long-term as a cancer prevention? For PCOS now PMOS (16:00) Which fertility method do you recommend, Marquette or Clearblue? (24:20) Metformin for PCOS? (26:57) Male infertility (29:15) Alex cooper is Pregnant (43:00). Resources mentioned: Dr. Duane’s website: https://www.factsaboutfertility.org/ Physician-Clincian Educator Directory: https://www.factsaboutfertility.org/facts-physician-clinician-educator-directory/ Marquette Method Instructors: https://www.marquettemethod.com/instructors/ More marquette Method Instructors https://www.mmnfp.com/instructors https://mycatholicdoctor.com/ Raising Testosterone with Sal di Stefano: https://omny.fm/shows/trending-with-timmerie-catholic-principles-applied/how-to-increase-testosterone-1 The Happy Girl’s Guide to Being Whole: What You Never Knew about Your Natural Body: https://www.amazon.com/Happy-Girls-Guide-Being-Whole/dp/1735223727 Ultimate Girls & Guys Body Books: https://www.rainbowresource.com/ultimate-girls-guys-body-books IFS Study shows you're healthier and happier when you marry https://ifstudies.org/blog/does-marriage-really-make-us-healthier-and-happier

Episode 2808 - In this information-dense and wide-ranging episode, Ted and Austin Broer connect landmark natural diabetes research, 5G neurological damage documentation, Israel's systematic destruction of Lebanese civilian infrastructure, obesity-driven cognitive decline, and a coming global whey protein shortage into one of their most practically valuable and geopolitically urgent broadcasts in recent memory. The episode opens with Austin presenting an extraordinary stack of natural insulin resistance reversal research covering eight documented compounds including curcumin, Dihydro Berberine, cinnamon extract, ginger, black seed oil, olive leaf extract, berries, and spirulina. The curcumin data stands out as particularly striking, with a 2009 study showing it to be 500 to 100,000 times more effective than Metformin at activating glucose uptake and a separate clinical trial demonstrating 100% prevention of type 2 diabetes onset in prediabetic patients over nine months.

Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it.

Send us Fan MailYour supplement shelf can turn into a silent monthly subscription, and the scariest part is not the cost. It's the uncertainty. We sit down to unpack why supplements so often feel like a black box, how isolated nutrients can behave differently than nutrients in whole foods, and what a sensible, evidence-based supplement routine looks like when you care about real outcomes like strength, metabolic health, energy, and long-term resilience. We walk through the decision filters we use as clinicians, starting with the most straightforward case: measured deficiencies you can actually track, like vitamin B12 or vitamin D. From there, we share John's “Four I's” checklist (imbalance, insufficiency, infection, isolation) and why the food matrix matters so much when you're deciding between a capsule and a plate. We also get specific about common scenarios, including vegan and plant-based nutrient gaps (especially zinc and B12), aging and fatty acid needs, and why omega-3 fish oil studies can look mixed compared with the consistent benefits of eating oily fish. We dig into risks that don't get enough airtime, including supplement overload, vitamin toxicosis concerns, and medication-driven nutrient depletion. Metformin and B12, statins and CoQ10, and proton pump inhibitors and mineral absorption all come up, along with a bigger theme: changing a biomarker is not the same as improving an outcome. To keep things grounded, we share what we actually take right now, why creatine has one of the strongest evidence bases in sports nutrition and healthy aging, how creatinine lab values can be misread, and where berberine and targeted probiotics like Akkermansia may fit for metabolic health when paired with lifestyle changes. We close with practical tips on supplement quality and third-party testing, plus how to build a short-term “bridge” plan with clear stop rules. Subscribe for more evidence-based self-care, share this with someone whose cabinet is overflowing, and if you found this helpful, leave a review and tell us what supplement you want us to break down next. For video recording and open source reference articles: www.thehealthedgepodcast.com

What if the people case-managing your care had a financial reason to keep you sicker? That's the uncomfortable question Scott Middleton puts on the table in this episode — recorded live from the American Case Managers Conference in Orlando, where Scott went to learn, and ended up being told Your Health didn't "fit" because they weren't a hospital. Jamie and Scott unpack what the nurse case manager role actually looks like at Your Health — and why moving case management out of hospitals and into patients' homes isn't just better care, it's better economics. Scott shares the research proving the model works: 50% reduction in Medicare spend when patients are seen at the right frequency by the right people. In this episode: Why hospitalists may be "the demise of the American healthcare system" The difference between nurse practitioners (diagnose and treat) and nurse case managers (assess and guide) — and why blurring them costs patients The 16.05-visits-per-risk-point model David Clemens' research validated How coding departments are quietly diagnosing patients with diseases they don't have Why Medicare's 6-year insolvency window may be the disruption we need Head-to-toe assessments, delegation rights, and the real job of an RN in the home If you've ever suspected the system is working exactly as designed — just not for the patient — press play. www.YourHealth.Org

Cancer has long been understood through a variety of biological frameworks, including genetic mutations, dysregulated signaling pathways, and uncontrolled cell proliferation. Yet, these models often capture the visible consequences of disease rather than the deeper metabolic dependencies that sustain tumor survival. Despite major advances in targeted therapies, a central challenge remains: what underlying mechanisms make cancer cells vulnerable to treatment, and how can these vulnerabilities be exploited more effectively? Increasing attention has shifted toward cellular metabolism—particularly lipid regulation and energy-sensing pathways such as AMPK—as critical determinants of tumor behavior. Scientists are now taking a closer look at how metabolism works together with stress responses like autophagy—and how this connection could be used to develop better cancer treatments. A new research paper was published in Volume 17 of Oncotarget, titled “The SCD1 inhibitor aramchol interacts with regorafenib and metformin to kill tumor cells.” The study was led by first author Michael R. Booth and corresponding author Paul Dent from Virginia Commonwealth University, in collaboration with Laurence Booth and Jane L. Roberts from Virginia Commonwealth University and John M. Kirkwood from the University of Pittsburgh Cancer Institute. Full blog - https://www.oncotarget.org/2026/04/21/scd1-inhibition-strategy-shows-potent-synergy-with-regorafenib-and-metformin-in-tumor-cell-killing/ Paper DOI - https://doi.org/10.18632/oncotarget.28861 Correspondence to - Paul Dent - paul.dent@vcuhealth.org Abstract video - https://www.youtube.com/watch?v=lmX_c2e_-HY Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28861 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, macroautophagy, ER stress, aramchol, regorafenib, BID To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Website: ⁠⁠⁠https://hunterwilliamshealth.com/⁠⁠Get my FREE Cheatsheet: ⁠https://hunterwilliamshealth.com/peptidecheatsheet⁠Join My Private Group: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://theaxioncollective.manus.space/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠⁠⁠⁠⁠Today I'm breaking down something that's been blowing up in the peptide world. The FDA just made a major announcement about moving 19 popular peptides from Category 2 to Category 1. And I want to share my honest thoughts on what this actually means for you.First I walk through how we got here. The Biden administration's original scheduling decision. The rise of the research peptide market. And why roughly four out of five peptides consumed in the US today come from research companies.Then I get into what the FDA is actually proposing. The July hearing. The February 2027 timeline. And what Category 1 status would mean for compounding pharmacies and telehealth clinics.But here's where it gets interesting. I share my prediction on where prices are headed and why I think we'll eventually see price parity between prescribed and research peptides. I also dig into what I think is a quiet quid pro quo happening between Big Pharma and the FDA around GLP-1s.This is speculation on my part. I'm not a doctor or a lawyer. But I wanted to give you my honest read on where this is all going. Let me know your thoughts in the comments.Timestamps00:00 — Intro and disclaimers (not a doctor, not a lawyer)01:40 — History: How the Biden FDA scheduled 19 peptides as Category 202:44 — The rise of the research peptide gray market (4 out of 5 peptides)04:18 — RFK on Joe Rogan and the FDA's Category 1 plans04:58 — What Category 1 actually means (Sermorelin example)05:42 — The July hearing and February 2027 final say timeline07:18 — FDA cracking down on GLP-1s from research companies08:42 — More compounding pharmacies and telehealth clinics entering the space09:08 — The Metformin analogy and future price parity13:20 — The rug pull theory: FDA and Big Pharma quid pro quo on GLP-1s14:04 — Why Eli Lilly is protecting retatrutide (projected $50B/year product)17:04 — Final thoughts and the golden age of peptides

Hour 3 for 4/8/26 Dr. Sean O'Mara joins Drew to discuss GLP-1s and their associated risks (5:20). Topics/calls: reduced motivation for life (12:56), Keto + GLP-1 combo (17:14), veteran on GLP-1s (20:56), Metformin (28:24), limited dose (34:07), fermented foods (36:39), toxicity (43:22), natural strategies (45:22), not gaining weight (46:40). Links: https://drseanomara.com/ https://x.com/DrSeanOMara

In his weekly clinical update, Dr. Griffin and Vincent Racaniello cover if the "five-second" rule for things that fall on the floor apply to surgical equipment, an outbreak of E. coli illness caused by raw cheese before Dr. Griffin then deep dives into the measles outbreak in South Carolina and Utah, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, strain selection for the 2026-2027 season influenza vaccine by the FDA, if standard or high dose influenza vaccination influences dementia protection, a new variant of SARS-CoV-2, how to access and pay for Paxlovid, specific effects of Paxlovid and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode The "five-second" rule for dropped food: does it apply to dropped medical objects in the operating room? A randomized study of disinfection approaches for contaminated arthroplasty implants (Infection Control & Hospital Epidemiology) Whole Genome Sequencing (WGS) Program (FDA) Outbreak Investigation of E. coli O157:H7: Raw Cheddar Cheese (March 2026) (FDA) Wastewater for norovirus (WasterWater Scan) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) UtahMeasles Dashboard (Utah Department of Health and Human Services) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles(CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) USrespiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) Risk of Alzheimer Dementia After High-Dose vs Standard-Dose Influenza Vaccination (Neurology) Weekly surveillance report: clift notes (CDC FluView) OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) USrespiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Respiratory Diseases (Yale School of Public Health) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Respiratory viral infections prime accelerated lung cancer growth (Cell) Early Detection and Surveillance of the SARS-CoV-2 Variant BA.3.2 — Worldwide, November 2024–February 2026 (CDC: MMWR) Where to get pemgarda (Pemgarda) EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) UnderstandingCoverageOptions (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulationguidelines (hematology.org) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Paxlovid shows organ-specific and age-specific impacts on risk of developing post-acute sequelae of COVID-19 (Communications Medicine) The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID (Annals of Internal Medicine) Reaching out to US house representative Letters read on TWiV 1310 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.

BUFFALO, NY – March 31, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on March 27, 2026, titled “The SCD1 inhibitor aramchol interacts with regorafenib and metformin to kill tumor cells.” Led by Michael R. Booth, Laurence Booth, and Jane L. Roberts from Virginia Commonwealth University, with corresponding author Paul Dent from the same institution and John M. Kirkwood from the University of Pittsburgh Cancer Institute, the study examines how aramchol interacts with regorafenib and metformin to kill tumor cells, particularly patient-derived uveal melanoma (UM) cells and cholangiocarcinoma cells. The authors report that aramchol, regorafenib, and metformin interact to enhance tumor cell killing, with the strongest effects seen when metformin is added to aramchol plus regorafenib. In patient-derived UM cells and LD-1 cholangiocarcinoma cells, the three-drug combination increased autophagosome formation and autophagic flux, while knockdown of Beclin1, ATG5, or LAMP2 reduced autophagosome and autolysosome formation and lowered cell killing. The study also found that BID contributes to the lethal response, supporting a multifactorial mechanism involving macroautophagy and death-receptor signaling. “Our data demonstrates that UM cells are killed by treatment with aramchol plus regorafenib plus metformin via enhanced autophagic flux and that this combination may have the potential to control UM tumors that have metastasized to the liver.” The authors also note that while SCD1 knockdown increased baseline tumor cell death, it did not replicate the full anticancer effects of aramchol, suggesting additional molecular targets contribute to its activity. They emphasize the need for further in vivo studies to evaluate the therapeutic potential of this combination in metastatic uveal melanoma, particularly in liver-targeted disease. DOI - https://doi.org/10.18632/oncotarget.28861 Correspondence to - Paul Dent - paul.dent@vcuhealth.org Abstract video - https://www.youtube.com/watch?v=lmX_c2e_-HY Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28861 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, macroautophagy, ER stress, aramchol, regorafenib, BID To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Dietitians Torwen Eerkens and Aidan Muir deep dive on berberine, an emerging supplement dubbed 'Nature's Metformin'. Torwen and Aidan examine the potential benefits, risks and practical implications.  (1:40) - Diabetes Management   (2:48) - Effect on Cholesterol   (3:49) - Weight Management (6:03) - Fatty Liver Disease (7:16) - How to Take Berberine (9:30) - Potential Side Effects & Impracticalities of Berberine WEBSITE:  https://www.idealnutrition.com.au/ PODCAST:  https://www.idealnutrition.com.au/podcast/ INSTAGRAM:  https://www.instagram.com/idealnutrition__/?hl=en Our dietitians

It's In the News, a look at the top headlines and stories in the diabetes community. This week's top stories: Metformin may help stem macular degeneration, retatutride moves forward, T1D and demntia link studied, lots of news from ATTD and more! Announcing Community Commericals! Learn how to get your message on the show here. Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom  All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  transcript with links:  Welcome! I'm your host Stacey Simms and this is an In The News episode.. where we bringing you the top diabetes stories and headlines happening now. A reminder that you can find the sources and links and a transcript and more info for every story mentioned here in the show notes. Who's in Vegas? I'll see you there at the Breakthrough T1D summit this weekend. And we have two Club 1921 events for health care providers and patient leaders happening in April – head on over to the website for more. Okay.. our top story this week: XX Metformin may be linked to the slower progression of age-related macular degeneration (AMD). Among people with diabetes who were older than 55, those taking metformin had a 37% lower chance of developing intermediate AMD over a five-year period compared with individuals who were not using the medication. It's one of the leading causes of vision loss in the US and many other western countries. These researchers now say a clinical trial is the next step. https://scitechdaily.com/scientists-discover-surprising-eye-benefit-of-widely-used-diabetes-drug/ XX new study suggests people with type 1 diabetes may be nearly three times as likely to develop dementia compared with people without diabetes. Similarly, people with type 2 diabetes may have roughly twice the risk of dementia compared with those without diabetes. However, the study found an association rather than proof of causation, meaning diabetes was linked to dementia risk but was not shown to directly cause it.   https://www.usnews.com/news/health-news/articles/2026-03-19/both-types-of-diabetes-increase-dementia-risk XX Researchers in Japan say they've developed an insulin pill… in mice.  The study, published in the journal Molecular Pharmaceutics, tested the delivery of oral insulin by building a carrier peptide called DNP-V. This peptide helps to transport insulin through the small intestine, where protein drug absorption is usually poor. The result was a rapid and significant drop in blood glucose, as well as a sustained (longer-term) decrease. The mice's blood sugar was reduced to near-normal levels. Although the researchers are optimistic about the findings translating to larger therapeutic models, they noted that the results in mice do not guarantee the same outcome in humans, and that more research is needed. https://www.foxnews.com/health/needle-free-diabetes-management-could-horizon-study-suggests   XX   Lilly says it's next-generation obesity drug retatutride cleared its first late-stage trial on Type 2 diabetes patients. The drug lowered hemoglobin A1C by an average of 1.7% to 2% across different doses at 40 weeks compared with placebo, and helped patients lose an average of 16.8% of their weight. Retatrutide also met the study's second goal, helping patients at the highest dose lose an average of 16.8% of their weight, or 36.6 pounds, at 40 weeks, when evaluating only patients who stayed on the drug. When analyzing all participants, including those who discontinued treatment, the highest dose of the drug helped patients lose 15.3% of their weight. The company was also "very pleased" with the relatively low discontinuation rates due to side effects, which were up to 5%, he added. But Lilly has yet to file for approval of the drug for obesity or diabetes. The company expects to report findings from seven additional phase three trials on the drug by the end of the year. Still, retatrutide's A1C reduction doesn't appear to be the greatest Lilly has seen within its portfolio: The highest dose of Zepbound lowered the measure by more than 2% at 40 weeks in two separate trials on diabetes patients. Dubbed the "triple G" drug, retatrutide works by mimicking three hunger-regulating hormones – GLP-1, GIP and glucagon – rather than just one or two like existing treatments. That appears to have more potent effects on a person's appetite and satisfaction with food than other treatments.   https://www.cnbc.com/2026/03/19/eli-lillys-obesity-drug-retatrutide-clears-late-stage-diabetes-trial.html XX   The MiniMed Flex gets FDA approval. Thi is a new design from the company formerly known as Medtronic. It's about half the size* of the MiniMed™ 780G pump, no screen – smartphone controlled – and has the SmartGuard™ algorithm with Meal Detection™ technolog. At commercial launch, MiniMed Flex™ will support the company's newest sensor portfolio, including Simplera Sync™ sensor and the Instinct sensor, made by Abbott. MiniMed also announced the MiniMed™ Forward Program, which allows customers who start on the MiniMed™ 780G system to upgrade to the MiniMed Flex™ system for $0. MiniMed Flex™ is cleared for individuals ages 7 and older with type 1 diabetes, and for individuals 18 years and older with insulin-requiring type 2 diabetes. https://www.prnewswire.com/news-releases/minimed-announces-fda-clearance-of-minimed-flex-the-companys-smallest-insulin-pump-featuring-its-first-smartphone-controlled-design-302716864.html   XX Lots of new out of the recent ATTD conference.. some headlines: New study from the UK shows that Ketone Monitoring Could Significantly Reduce DKA Risks in people with type 1 and type 2. This was a study by Abbott which recently submitted a continuous dual glucose-ketone monitor to the FDA for clearance – if approved, it could be available in the U.S. later this year. -- The first modified insulin producing cells are still working 14 months after transplant – without the need for immunosuppressive drugs. This is from Sana which now plans a study of a new therapy.. same gene-editing strategy with lab-grown, stem-cell-derived insulin-producing cells. -- Protein looks like it helps avoid lows during exercise. Both high and low doses of whey protein before exercise were effective, significantly reducing the risk of hypoglycemia by five to 10 times.   Researchers noted that the body's response to protein was rapid (within 20 minutes), which suggests taking it close to the beginning of exercise could be beneficial for preventing hypoglycemia. Though more research is needed, there was also evidence showing protein intake could be beneficial for prolonged fasting and preventing overnight lows. -- More info about type 1 and GLP medications. Researchers at ATTD presented the results of a small, seven-month study assessing the effectiveness of semaglutide for people with type 1 diabetes and obesity. During the trial, 36% of participants taking semaglutide spent more than 70% of their time in range, less than 4% of their time below range, and lost more than 5% of their body weight compared to those not taking semaglutide.   Treatment with semaglutide was also associated with reductions in cholesterol and blood pressure. Based on all of these changes, the researchers calculated that the participants who received semaglutide had significantly reduced their risk of heart disease over the next 10 years.   Other studies show that since 2020, prescriptions of GLP-1 medications have grown exponentially for adults with type 1 diabetes between the ages of 18 and 85. https://diatribe.org/diabetes-research/top-diabetes-news-attd-2026   XX Lots of talk about fully closed loops.. CamDiab unveiled theirs.. called Liberty.. which the company says it's the world's first fully closed loop commercial launch. CamDiab offers the FDA-approved mylife CamAPS FX app for automating insulin delivery in MyLife's (formerly Ypsomed Diabetes Care's) insulin delivery pumps. The mylife CamAPS FX on iOS has full compatibility with leading continuous glucose monitors (CGMs). Those include the FreeStyle Libre 3 and Libre 3 Plus from Abbott and the Dexcom G6 so customers can use their preferred device. https://www.drugdeliverybusiness.com/camdiab-unveils-fully-closed-loop-insulin-feature/ XX Insulet reported data on a fully closed-loop automated insulin delivery system in people with Type 2 diabetes. The 24 people in the trial spent 24% more time in the target blood glucose range using the system than when receiving standard injection therapy. Insulet plans to start a pivotal study this year and aims to launch in 2028. Rival insulin pump manufacturer Tandem is on a similar course. Tandem CEO John Sheridan told investors on an earnings call last month that his team plans to start a pivotal trial this year to support a filing with the Food and Drug Administration in 2027. Medtronic disclosed the start of a pivotal trial of its Vivera fully closed-loop algorithm last month, shortly before spinning off the program as part of the MiniMed initial public offering. The algorithm, which is designed to eliminate carb counting and manual food bolusing, achieved a mean time in range of 73.8% without manual user input in a feasibility study.   https://www.medtechdive.com/news/insulet-posts-clinical-data-on-fully-closed-loop-insulin-delivery-system/814516/ XX Congrats to all honored by the 2026 National Scientific and Health Care Achievement Awards from the American Diabetes Association! Shout out to Diana Isaacs, PharmD, BCACP, BC-ADM, CDCES: 2026 Outstanding Educator in Diabetes Award and to  Korey Hood who receives the Richard Rubin award. Dr. Rubin was a pioneer in behavioral science and committed to keeping the person with diabetes at the center of research and care.

Peter Cummings is a preventive health practitioner and endurance sports coach with more than 30 years of experience helping people improve metabolic health through exercise, nutrition, and lifestyle change. A Metabolic Health Practitioner (MHP) and Nutrition Network Practitioner (NNP), he specializes in therapeutic carbohydrate reduction, cardiorespiratory fitness, and personalized exercise prescription. Cummings has authored peer-reviewed research in the American Journal of Preventive Medicine – FOCUS and has helped train health professionals to integrate fitness and lifestyle interventions into clinical care. In addition to his work in preventive medicine, he has coached athletes to multiple national and state championship titles, bringing a data-driven approach to both human performance and chronic disease prevention.    In this episode, Dr. Tro, Dr. Brian and Peter talk about… (00:00) Intro (01:56) VOT Max (04:19) Health Ballistics (Peter's new book!) (10:00) Bridging the gap between medicine and exercise (16:59) Berberine and Metformin (19:45) Helping people turn their health around and reverse diabetes (29:12) Cardiac rehab (34:43) Interval training (39:21) Carbs and exercise (42:56) Conflicts of interest in exercise science (45:45) The biggest barriers to systemic change in the fields of exercise science and nutrition (48:07) Tim Noakes' Central Governor Theory (55:09) Exercise physiology and fat burning (01:04:51) Peter's new book, Health Ballistics (01:09:35) Outro   For more information, please see the links below. Thank you for listening!   Links:   Please consider supporting us on Patreon: https://www.lowcarbmd.com/   Peter Cummings: Plan 2 Peak: https://www.plan2peak.com/ IG: https://www.instagram.com/coachcumm/ Linktree: https://linktr.ee/plan2peak?   Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author   Dr. Tro Kalayjian:  Website: https://toward.health Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/   Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.    Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://toward.health/community/

Full Show Notes: bengreenfieldlife.com/498 In this solosode I kick off by talking about whether isometric training is worth your time, covering both my own fitness habits and the newest research, particularly for runners and joint health. I also unpack a buzzworthy study on how just 10 minutes of vigorous exercise daily can be a powerful longevity booster compared to longer, lighter workouts. I share why I no longer personally use metformin, and instead, offer my favorite natural alternatives for better blood sugar control—like berberine, fiber, cinnamon, and simple routines like salads and walks. Plus, I get into brain health, explaining the roles of ketones, methylene blue, and near-infrared light for cognitive performance and protecting against issues like Alzheimer’s. At the end, I answer listener questions on optimizing DHT levels, natural insulin-sensitizers, and keeping your hair healthy even if you’re on testosterone. If you’re interested in practical strategies and learning what’s currently working in my own routine, you’ll enjoy this episode. Episode Sponsors: Hiya: Give your kids the full-body nourishment they need to grow into healthy adults. I’ve secured a special deal with Hiya on their best-selling children's vitamin—get 50% off your first order today! To claim this deal, you must go to hiyahealth.com/BEN (it is not available on their regular website). BASED Bodyworks: BASED Bodyworks is a clean, plant-based men's grooming brand offering simple, high-performance essentials from shampoo and skincare to styling, formulated without harsh sulfates or hormone-disrupting chemicals, so you can look and feel your best without compromising your health. Visit basedbodyworks.com and use code BOUNDLESSLIFE for 20% off. Manukora: You haven’t tasted or seen honey like this before - so indulge and try some honey with superpowers from Manukora. If you head to manukora.com/ben or use code BEN, you’ll automatically get $25 off your Starter Kit. Apollo: Apollo is a safe and non-invasive wearable that actively improves your sleep. Head over to apolloneuro.com/bengreenfield and use code BENGREENFIELD for $90 off.See omnystudio.com/listener for privacy information.

In dieser Folge spreche ich mit Hormoncoach Julia über PCOS (Polyzystisches Ovarialsyndrom) und warum die Diagnose nicht bedeutet, dass du machtlos bist. Wir reden über typische Symptome und warum Pille oder Metformin nicht die einzigen Optionen sind.Wenn du deinen Zyklus regulieren, deine Hormone natürlich unterstützen oder trotz PCOS schwanger werden möchtest, bekommst du hier fundiertes Wissen, persönliche Erfahrungen und konkrete Impulse.———————————————————Im Podcast erwähnt:PCOS Bundle von Femblends - Rabattcode: hannah5Julias Instagram: @juliaschultz.coachingJulias Website: www.juliaschultz.net⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠———————————————————Du möchtest keine Folge verpassen und zusätzliche Tipps direkt in dein Email Postfach bekommen? Dann melde Dich für meinen Newsletter an und erhalte meine 5 Tipps für ein gesünderes Leben in einem kleinem eBook.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Newsletter & Freebie⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Deine Gedanken zu meinem Podcastfolge kannst Du mir diese gerne auf Instagram @ernaehrungscoach.hannah mitteilen.Ich freue mich über jede Anregung und jeden Kommentar zu meinem Podcast. Schicke mir deine Gedanken gerne als email an ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠info@hannah-willemsen.com,⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ hinterlasse mir hier oder auf ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ einen Kommentar.Du würdest mir einen riesen Gefallen tun, wenn Du meinen Podcast auf ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠iTunes⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ mit 5 Sternen bewertest. So finden andere diesen Podcast auch und erhalten ebenfalls wertvolle Tipps zum Thema gesunde Ernährung.Alles LiebeDeine Hannah

If you're tired of taking handfuls of diabetes medications every day and watching your health decline anyway, this episode is for you! What if you could get off insulin, Metformin, Ozempic, and all your other diabetes meds while actually lowering your blood sugar? Sounds impossible, right? But it's not only possible, it's happening for thousands of people right now. And that could include you! In this episode, Dr. Jeffrey Hockings, founder and CEO of Diabetes Reversal Group, reveals the patented protocol that's helped over 10,000 people completely reverse type 2 diabetes and get off all their medications. Dr. Hockings shares the exact foods, supplements, and lifestyle strategies that work, plus real patient stories, like a man who went from taking over 300 units of insulin daily to zero medications in just six months. Listen to this episode and start your journey to medication-free health today! For show notes, visit https://fivejourneys.com/podcasts/how-to-stop-taking-metformin-insulin-and-ozempic-for-good/  Follow us on Instagram at https://www.instagram.com/feelfreakingamazing/  Related Episodes Reverse Pre-Diabetes with a Fasting-Mimicking Diet, with Dr. Joseph Antoun Reverse Chronic Diseases using Allulose, with Neil Gyte Lose Weight By Improving Your Leptin Sensitivity, with Dr. Bindiya Gandhi Lose Weight By Getting Healthy, with Ben Azadi

In today's episode, we're talking about cardiovascular health. Heart disease remains the #1 threat to the quality and quantity of life for Americans. And this is not because of a metformin or statin deficiency. We are pumping these drugs out at all time highs, but have yet to make a dent in heart disease. If you are in the traditional medicinal model, you may not be privy to the fact that there are other ways of supporting and invigorating the cardiovascular system and the underlying drivers of heart disease. You can actually improve cholesterol balance, blood sugar, arterial inflammation, and vascular health with natural means. Let's talk about where to start. Two fruit extracts that can help are bergamot and amla. You know I am a big fan of fruit and these two in particular positively influence: LDL cholesterol Triglycerides HDL Insulin sensitivity Arterial stiffness Vascular Oxidative stress You can find these two science-backed fruit extracts in Cardio Supreme.   -------- Connect with Dr. Matt online:  

Are medications solving the root of metabolic disease — or just masking it? In this powerful episode that started as a Instagram LIVE, I break down what you're not being told about the most commonly prescribed drugs for blood sugar, cholesterol, and weight loss: GLP-1s (Ozempic, Wegovy), statins, and Metformin. I help you unpack: What these medications actually do (mechanisms of action) The real data behind their risk reduction claims How statins may suppress natural GLP-1 production Why GLP-1s cause significant muscle loss, not just fat loss Why Metformin doesn't reverse insulin resistance More importantly, I walk you through what does restore metabolic health — including a system that's helping real people normalize labs, lose weight, and feel better without long-term prescriptions. What You'll Learn: The surprising truth about how statins impact your gut hormones Why insulin resistance — not cholesterol — is the real root cause How GLP-1 drugs work and what happens when you stop them The 3-step system to support blood sugar and cholesterol naturally How to evaluate your labs beyond A1C and LDL Resources Mentioned: Join my 90-Day Insulin Reset: Comment RESET on Instagram or Facebook and I'll DM you the link- https://shanahussinwellness.com/programs-courses/reset/ Feel Great Nutraceuticals: The first step to restoring insulin and liver function- https://shanahussinwellness.com/programs-courses/feelgreat/ Connect with Shana: Instagram: @shana.hussin.rdn Website: shanahussinwellness.com Facebook: Shana Hussin Wellness

Have you ever heard of inositol? Could you be deficient and not even realize it? If you're struggling with blood sugar swings, irregular cycles, anxiety, or 2am wake-ups, could this overlooked compound be a missing piece? While magnesium, B vitamins, and electrolytes dominate most wellness conversations, myo-inositol plays a critical role in insulin signaling, ovarian function, and neurotransmitter balance, acting as an intracellular messenger that helps your cells properly respond to hormonal cues. This episode unpacks what myo-inositol actually is, how it functions in the body, and what the research shows in areas like PCOS, insulin resistance, fertility, mood disorders, and sleep. It also covers therapeutic dosing, food sources, and how to use supplementation strategically for clinical outcomes. Whether you're navigating hormone imbalance, metabolic dysfunction, or nervous system dysregulation, this conversation takes a deeper look at why myo-inositol deserves far more attention in root-cause medicine. Also in this episode: What is inositol? What does it do in the body? What causes myoinositol deficiency? Symptoms of deficiency Episode 470: SSRIs on the Rise: Concerns and Safer alternatives Episode 430: Keto and PCOS Inositol and Metabolic Health Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome | New England Journal of Medicine Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial - PubMed Potential role and therapeutic interests of myo-inositol in metabolic diseases - PubMed Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials - PMC  Myoinositol vs. Metformin in Women with Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial - PMC The Comparative Effects of Myo-Inositol and Metformin Therapy on the Clinical and Biochemical Parameters of Women of Normal Weight Suffering from Polycystic Ovary Syndrome Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials - PubMed Full article: Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials Inositol for Mental Health Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder - PubMed Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder - PubMed Inositol treatment of obsessive-compulsive disorder - PubMed D-Chiro inositol vs. Myoinositol Food sources of inositol Dosage, safety and tolerability 1-2 scoops Relax and Regulate  This episode is sponsored by Naturally Nourished Relax and Regulate Relax & Regulate has always been a superstar for sleep, stress, and hormone support, and we've taken a good thing and made it even better! We've seen incredible results with 1000's of clients using Relax and Regulate literally every day for 10+ years now.    We have increased magnesium bisglycinate from 200 mg to 250 mg to match clinical sleep research dosing, kept myo-inositol at the full 4-gram therapeutic dose, and improved the supporting ingredients so the entire formula is better absorbed, better tolerated, and more aligned with what we're seeing clinically every day. Use code RELAX15 to save 15% on our reformulated Relax and Regulate! 

In his weekly clinical update during Ground hog week, Dr. Griffin and Vincent Racaniello are back to discuss the measles outbreak in South Carolina, American Academy of Pediatrics vaccine recommendations and shingles vaccine and the reduction of dementia, then deep dives into recent statistics RSV, influenza and SARS-CoV-2 infections, the Wastewater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, how to access and pay for Paxlovid, estimated effectiveness of this year's COVID-19 vaccine, long COVID treatment center, where to go for answers to your long COVID questions, long COVID in children, the potential benefits of metformin to reduce disease severity following SARS-CoV-2 infection in obese and overweight patients and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Grading the groundhogs (National Oceanic and Atmospheric Administration) Sand Mountain Sam predicts an early spring (News19) All About the AAP Recommended Immunization Schedule (healthychildren.org) Recommended Childhood and Adolescent Immunization Schedule: United States, 2026: Policy Statement (American Academy of Pediatrics: Pediatrics) Herpes zoster vaccination and incident dementia in Canada: an analysis of natural experiments (LANCET: Neurology) Detection of avian flu antibodies in Dutch dairy cow: ECDC risk assessment remains unchanged (European Centre for Disease Prevention and Control) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard(South Carolina Department of Public Health) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles(CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) USrespiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Estimated Effectiveness of 2024-2025 COVID-19 Vaccination Against Severe COVID-19 (JAMA) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulationguidelines (hematology.org) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR): a retrospective cohort study (LANCET: Infectious Diseases) Long COVID is here to stay—even in children (LANCET: Infectious Diseases) Early administration of neutralising monoclonal antibodies and post-acute sequelae of COVID-19 (International Journal of Infectious Diseases) Preventing Long COVID With Metformin (CID) Metformin may reduce risk of long COVID by 64% in overweight or obese adults (CIDRAP) Effect of Metformin on the Risk of Post-coronavirus Disease 2019 Condition Among Individuals With Overweight or Obese (CID) Preventing Long COVID With Metformin (CID) New review highlights growing evidence that diabetes drug metformin can prevent long COVID (CIDRAP) Reaching out to US house representative Letters read on TWiV 1294 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.

Doctors Lisa and Sara talk to Consultant Nephrologist Dr Darren Green about patients with Type 2 Diabetes who also have Chronic Kidney Disease and Heart Failure.  We go through a hypothetical case to illustrate some of the finer points of management that can commonly get missed or might not be appreciated. A really detailed talk full of useful practice enhancing tips for this complex group of patients.  Disclaimer: All educational content in this podcast was developed as part of the Circulation Health collaborative working project between Boehringer Ingelheim Limited, Greater Manchester Primary Care Provider Board and Health Innovation Manchester. Content has been created by Circulation Health Clinical Leads for educational purposes, reflecting NHS Clinical Lead and guideline-based recommendations. Boehringer Ingelheim had no input into content development. They have provided financial resources to support Podcast recordings related to this project. Darren would like us to make you all aware that he has working relationships with pharmaceutical industry partners. Specifically, that he has received speak fees and consultancy fees from AstraZeneca, GSK, Novartis, Boehringer Ingelheim, Bayer, and Lilly, and has been part of collaborative working agreements with Novartis, Boehringer Ingelheim, and AstraZeneca. You can use these podcasts as part of your CPD - we don't do certificates but they still count :) Resources: Dr Kevin Fernando counselling diabetic patients starting an SGLT2 Inhibitors like Dapagliflozin or Empagliflozin: https://www.youtube.com/watch?v=pc99SdtlsyU Diabetes UK counselling sheets on SGLT2 inhibitors: https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/sglt2-inhibitors Kidney Care UK Patient Booklets: https://kidneycareuk.org/get-support/free-resources/patient-information-booklets/ Pumping Marvellous Heart Failure Charity with patient resources: https://pumpingmarvellous.org/ International Society for Nephrology Toolkit for Initiating or Changing RAASi - Renin Angiotensin Aldosterone System Inhibitors (like ACEis such as Lisinopril or Ramipril, or ARBs like Candesartan on Losartan): https://www.theisn.org/initiatives/toolkits/raasi-toolkit/ Royal College of General Practitioners Acute Renal Failure Toolkit: https://elearning.rcgp.org.uk/course/info.php?id=899 CONFIDENCE trial: Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes | New England Journal of Medicine: https://www.nejm.org/doi/full/10.1056/NEJMoa2410659 ATLAS trial: Efficacy and safety of high-dose lisinopril in chronic heart failure patients at high cardiovascular risk, including those with diabetes mellitus: https://pubmed.ncbi.nlm.nih.gov/11071803/ Metformin lactic acidosis Metformin in Patients With Type 2 Diabetes and Kidney Disease: A Systematic Review: https://jamanetwork.com/journals/jama/article-abstract/2084896 UK AKI Summit report UKKA AKI Summit Report + Recommendations: https://share.google/7uw1GPQ5sV2riJtiV RCGP AKI follow up  post discharge recommendations: https://bjgpopen.org/content/early/2020/06/15/bjgpopen20X101054/tab-figures-data?versioned=true ___ We really want to make these episodes relevant and helpful: if you have any questions or want any particular areas covered then contact us on Twitter @PCKBpodcast, or leave a comment on our quick anonymous survey here: https://pckb.org/feedback Email us at: primarycarepodcasts@gmail.com ___ This podcast has been made with the support of GP Excellence and Greater Manchester Integrated Care Board. Given that it is recorded with Greater Manchester clinicians, the information discussed may not be applicable elsewhere and it is important to consult local guidelines before making any treatment decisions.  The information presented is the personal opinion of the healthcare professional interviewed and might not be representative to all clinicians. It is based on their interpretation of current best practice and guidelines when the episode was recorded. Guidelines can change; To the best of our knowledge the information in this episode is up to date as of it's release but it is the listeners responsibility to review the information and make sure it is still up to date when they listen. Dr Lisa Adams, Dr Sara MacDermott and their interviewees are not liable for any advice, investigations, course of treatment, diagnosis or any other information, services or products listeners might pursue as a result of listening to this podcast - it is the clinicians responsibility to appraise the information given and review local and national guidelines before making treatment decisions. Reliance on information provided in this podcast is solely at the listeners risk. The podcast is designed to be used by trained healthcare professionals for education only. We do not recommend these for patients or the general public and they are not to be used as a method of diagnosis, opinion, treatment or medical advice for the general public. Do not delay seeking medical advice based on the information contained in this podcast. If you have questions regarding your health or feel you may have a medical condition then promptly seek the opinion of a trained healthcare professional.

Send us a textWelcome back Rounds Table Listeners! In this solo episode, Dr. Mike Fralick discusses a recent trial looking at metformin for knee osteoarthritis in patients with overweight or obesity. Here we go!Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity:A Randomized Clinical Trial (0:00 – 8:19).The Good Stuff (8:20 – 9:13):Diabetes Trial Files (https://diabetestrialfiles.substack.com/) Trial Files (https://trialfiles.substack.com/)Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor answer listener mailbag questions from California, the UK, France, Washington, Wyoming, and beyond. The team breaks down why Dr. Cooper does not recommend calorie tracking (and when limited tracking can make sense), how to build confidence in eating without data, and why “mechanical eating” sometimes needs medical customization—especially for people with slow gut transit or gastroparesis-like symptoms. They also dig into bile acid malabsorption after gallbladder removal, when metformin side effects deserve a second look, what we currently know about COVID-19's potential impact on metabolic health, and why metformin and GLP-1 medications can be complementary—particularly in PCOS.Key Takeaways• Long-term calorie tracking can override physiologic cues and reinforce diet mentality.• Short-term, targeted tracking may be useful when guided by a clinician (e.g., nutrient deficiencies ).• Obesity and abnormal appetite are both manifestations of metabolic dysfunction—not simple cause and effect.• Mechanical eating is a framework, not a rigid rule—timing and food choices may need medical tailoring.• Post-gallbladder diarrhea may reflect bile acid malabsorption and can be treatable.• Metformin and GLP-1s often complement each other because they target different metabolic states (fasting vs fed).Dr. Cooper's Actionable Tips• Stop daily calorie counting—focus on consistent patterns and metabolic nourishment.• Use mechanical eating basics: eat every few hours, include all food groups, and reduce chemical additives when possible.• If you're transitioning away from tracking, consider a dietitian skilled in diet-mentality recovery.• If frequent eating worsens sleep or bloating, work with a medical dietitian to adjust intervals and food types (especially with slow GI transit).• If chronic diarrhea appears (especially after gallbladder removal), ask your clinician about bile acid malabsorption and treatment options.• Use labs to guide therapy: fasting insulin can signal metformin benefit; post-meal patterns can point toward GLP-1 needs.Notable Quote“Once you start using tracking to stay in a calorie range or a carbohydrate range, you're putting your brain in front of your physiologic intuition—your body is sending you important cues all the time.”—Dr. Emily CooperLinks & ResourcesThe Metabolic Links to PCOS, Release Date 2/24/25The COVID Connection to Diabetes & Metabolic Health, Release Date 12/16/24Podcast Home: https://fatsciencepodcast.com/Episode References: https://fatsciencepodcast.com/wp-content/uploads/2025/06/Scientific-References-Fat-Science-Episodes.pdfCooper Center: https://coopermetabolic.com/podcast/Resources from Dr. Cooper: https://coopermetabolic.com/resources/Submit a Question: questions@fatsciencepodcast.com*Fat Science: No diets, no agendas—just science that makes you feel better. This podcast is for informational purposes only and is not intended to be medical advice.

Send us a textThe AMP kinase pathway's role in cellular energy sensing, nutrient allocation, and its connections to health practices like fasting, exercise, and diet.TOPICS DISCUSSED:Cellular energy basics: ATP/ADP/AMP as energy currencies; AMP kinase activates on low ATP to conserve and redirect resources, like a budget manager.AMP kinase mechanics: Heterotrimeric enzyme phosphorylating 100+ substrates; localizes dynamically in cytosol, mitochondria, nucleus to integrate signals.Nutrient detection: Senses fatty acids in fasting/ketogenic states, boosting fat oxidation and mitochondria independent of energy drops.Fasting/exercise impacts: Elevate AMP kinase for mitophagy, better fuel switching; mimic historical scarcity absent under modern constant feeding.mTOR relationship: AMP kinase inhibits mTOR to stop growth in low energy states; feedback loop disrupted by abundance, promoting tissue buildup.Disease links: Low AMP kinase in obesity/diabetes reduces flexibility; activation prevents cancer but may aid tumor survival in therapy.Drugs/diets: Metformin and GLP-1s like Ozempic activate AMP kinase for glucose control/weight loss; ketogenic diets activate at intermediate levels for fat efficiency.ABOUT THE GUEST: Gregory Steinberg, PhD is a Professor of Medicine at McMaster University and co-directs the Centre for Metabolism, Obesity, and Diabetes Research, focusing on cellular energy sensors like AMP kinase.RELATED EPISODE:M&M 260 | Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha MuruganSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code TRIKOMES for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/This is a reaction video on Peter Attia's 60-second health take, from carnivore diets and testosterone to seed oils and fasting. Matt provides nuanced medical commentary on where he agrees, disagrees, and adds crucial context that Attia's format couldn't include. Woven throughout is the surprising personal story of how Matt's 60 Minutes interview led to VIP New Year's Eve passes from Anderson Cooper, blending high-level health analysis with human connection. The episode debates headline health claims while sharing a once-in-a-lifetime NYC experience.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:Timestamps: 0:00 Cold open: rapid-fire takes (carnivore, testosterone, fasting, deodorant, etc.)0:42 Season 3 renewal + new year intro1:01 Holiday recap1:31 Times Square ball drop + Anderson Cooper passes (60 Minutes connection)3:33 Setup: reacting to Peter Attia's 60 Minutes “rapid fire”4:14 Multivitamin: “pass” (insurance policy vs evidence)5:01 Metformin: “definitely pass” for non-diabetics6:04 Seed oils: modest quantities likely not harmful6:27 Mouth taping: useful for some mouth breathers6:51 Bluetooth headphones + EMF: what we know vs what's uncertain8:32 Weighted vests vs rucksacks: does it matter?9:33 Carnivore diet: “very extreme”9:47 Heavy metal “detox”: snake oil vs real testing and interventions11:27 Food dyes: “deck chairs on the Titanic” (majoring in the minor)14:53 Microplastics: what to change, pragmatic exposure reduction18:47 Hormone replacement therapy (women): “crime of the century” + WHI fallout21:50 Testosterone for men: net positive, but abused/scamified23:16 Testosterone for menopausal women: emerging evidence + clinical reality25:37 Sleep tracking + wearables: helpful unless it creates anxiety26:23 Deodorant vs antiperspirant: aluminum concerns and skin irritation28:43 Non-stick pans / PFAS: relative risk and practical choices29:52 Intermittent fasting: protein risk + eating-disorder cautions31:39 Wrap-up + subscribe/comments outrohttps://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/

Von Klassikern zu neuen Wirkstoffen: Orale Antidiabetika verständlich erklärt

Broadcast from KSQD, Santa Cruz on 1-08-2026: Dr. Dawn concludes her 2025 medical advances recap, noting that while GLP-1 weight loss drugs showed unexpected benefits for addiction, schizophrenia, and dementia risk, Novo Nordisk recently reported semaglutide had no effect on cognition in people with existing dementia or mild cognitive impairment. She describes the first successful human bladder transplant performed on May 4th. The 41-year-old recipient received both kidney and bladder due to the bladder's complex blood vessel network. Surgeons practiced on cadavers with active circulation before achieving success, opening pathways for future bladder-only transplants for the 84,000 Americans diagnosed with bladder cancer annually. An emailer follows up about purslane for cognitive health. Dr. Dawn reviewed the referenced studies and found neither actually supported claims about purslane and cognition—one discussed the Lyon Heart Study's Mediterranean diet, the other described antioxidant properties. She cautions listeners that websites citing "scientifically proven" claims often reference articles that don't support their assertions. An emailer asks about statin alternatives after developing severe muscle pain on both atorvastatin and rosuvastatin. Dr. Dawn suggests he shouldn't be on statins given his classic adverse reaction. She recommends ezetimibe plus oat bran for cholesterol, metformin for his elevated triglycerides indicating insulin resistance, and checking LDL particle size and inflammation markers. She emphasizes that cholesterol is a risk factor, not a disease, and treating 50 low-risk people for 10 years prevents only one heart attack. A caller discusses plaque formation theory, comparing it to calluses. Dr. Dawn explains Linus Pauling's similar hypothesis that plaque forms at vessel bifurcations to protect against turbulent blood flow damage. She warns against driving total cholesterol below 130, as it disrupts steroid hormone production. The caller shares his mother's near-fatal rhabdomyolysis from statins—muscle breakdown releasing myoglobin that clogs kidneys—and criticizes data transfer failures between hospital systems. An emailer reports four UTIs in two months at age 79. Dr. Dawn questions whether all were true infections, since vaginal contamination causes false positives on dipstick tests. For confirmed UTIs, she recommends D-mannose and cranberry to prevent bacterial adhesion, post-void residual ultrasound to check for incomplete emptying, lactobacillus probiotics, and vaginal DHEA (Intrarosa) to restore mucosal thickness and disease resistance. Dr. Dawn describes Stanford's Phase III trial for dystrophic epidermolysis bullosa, where defective collagen-7 causes skin layers to separate at the slightest touch. Researchers take patient skin biopsies, use retroviruses to insert corrected genes, grow credit-card-sized skin grafts over 25 days, then suture them onto wounds. At 48 weeks, 65% of treated wounds fully healed versus 7% of controls. She reports a Stanford study showing premature babies who heard recordings of their mothers reading for 2 hours 40 minutes daily developed more mature white matter in language pathways. The left arcuate fasciculus showed greater development than controls, demonstrating how early auditory stimulation shapes brain circuitry even in NICU settings. Dr. Dawn concludes with tattoo safety concerns. Modern vivid inks contain compounds developed for car paint and printer toner, including azo dyes that break down into carcinogenic aromatic amines—especially during laser removal. Pigment particles migrate to lymph nodes and persist in macrophages, causing prolonged inflammation. She advises those with tattoos to avoid laser removal, wear sunscreen, practice lymphatic hygiene, and reconsider extensive new tattoos.

Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comAre your immune cells aging faster than you are? In this episode, Dr. Gabrielle Lyon sits down with Dr. Anurag Singh, a leading physician-researcher and Chief Medical Officer at Timeline, to discuss a groundbreaking discovery: the gut-muscle-immune axis. While we often focus on muscle mass for longevity, new research published in Nature Aging reveals that our immune system undergoes a similar decline, with youthful sentinel cells (naive CD8 T-cells) dropping by 75% as we reach age 50. Dr. Singh explains how mitophagy —the targeted recycling of damaged mitochondria—is the key to "rewiring" an aging immune system to fight infection 20% more effectively. In this episode: Alzheimer's of the Muscle: Why sporadic inclusion body myositis (sIBM) is often misdiagnosed as simple aging. The Power of Urolithin A: How this postbiotic compound induces mitophagy to increase mitochondrial abundance by 20% in just 28 days. Immune Imprinting: Why children get 6-8 colds a year while adults only average 2-4. Repurposing Longevity Drugs: Dr. Singh's take on Metformin, Rapamycin, and GLP-1s for life extension. The 1:1 Exercise Rule:Why 150 minutes of moderate activity is the threshold for mitochondrial biogenesis. Thank you to our sponsors: BodyHealth - Use the code LYON 20 to get 20% off your first order https://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/ Timeline - Get 35% off a Mitopure subscription at https://www.timeline.com/drlyon Manukora - Go to https://www.MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts. Chapters: 0:00 - Can You Tell If Your Immune System Is Healthy? 1:37 - Alzheimer's of the Muscle: Muscle-Immune Dysfunction 5:59 - The Thymus Design Flaw: Why Our Immune "Ammo" Disappears 8:44 - Naive CD8 T-Cells: The Elite Forces of Immunity 12:24 - The Axis of Aging: Mitochondria and Immune Cells in Muscle 16:15 - Mitophagy vs. Autophagy: Targeted Cellular Recycling 19:11 - Study Review: Rewiring the Immune System with Urolithin A 24:13 - Mitochondrial Remodeling: Switching from Glucose to Fatty Acids 27:45 - The Trifecta: Gut-Muscle-Immune Axis Connection 31:13 - Parkinson's and the PINK1/Parkin Mitophagy Pathway 35:04 - Clinical Results: Improving Leg Strength in 4 Months 38:51 - Joint Health: Can We Remodel Cartilage with Mitophagy? 43:34 - Targeted Mitophagy Inducers: Exercise vs. Postbiotics 46:44 - Precision Nutrition: The Ideal Muscle Longevity Supplement 53:33 - Why Alzheimer's is Now Considered an Inflammatory Disease 1:00:13 - The Placebo Effect: You Cannot Deceive the Immune System 1:03:13 - Lymphocyte Counts: The Clinical Marker for Immune Aging 1:08:14 - Rapamycin and Metformin: The Future of Longevity Drugs 1:11:42 - Optimal Dosing: Why 1,000mg of Urolithin A is the Standard 1:15:13 - Sports Medicine: Reducing Muscle Damage Markers (Creatine Kinase) 1:20:03 - The Final Frontier: Brain Aging and Selenium Repair Connect with Dr. Anurag Singh Instagram: @timeline_longevity Website: https://www.timeline.comFind Dr. Gabrielle Lyon at: Instagram:@drgabriellelyon TikTok: @drgabriellelyon

Advancing longevity research is about honoring the value of life—and translating that respect into evidence-based prevention. If healthcare is judged by life expectancy + quality of life, longevity medicine may be one of the most meaningful metrics we can pursue: extending health span through early detection, validated biomarkers, and interventions that scale.This unforgettable Expert Panel from the 4th annual Medical Innovation Olympics (#MIO2025) convened all-star global leaders in Longevity and Preventive Medicine who separated hype from reality and outlined what it will take to bring longevity into mainstream care - rigorously, ethically, and accessibly.Topics include: breakthroughs (including epigenetic approaches pointing toward functional restoration of eyesight), biomarkers/endpoints as the “keystone” for faster trials, the TAME (Targeting Aging with Metformin) concept, and the role of standards, education, trust, and shared responsibility—keeping dignity central.Panelists:Dr. David Barzilai (Harvard Medical School; Geneva College of Longevity Science, GCLS) • Dr. Dominik Thor (President, GCLS) • Dr. Mishkat Shehata (Emirates Lifestyle & Longevity Medicine Society) • Keith Comito (Lifespan Research Institute) • Dr. Uma Senthilkumar (Three Five Revive)

Dr. DebWhat if I told you that the stomach acid medication you’re taking for heartburn is actually causing the problem it’s supposed to solve that your doctor learned virtually nothing about nutrition, despite spending 8 years in medical school. That the very system claiming to heal you was deliberately designed over a hundred years ago by an oil tycoon, John D. Rockefeller, to create lifelong customers, not healthy people. Last week a patient spent thousands of dollars on tests and treatments for acid reflux, only to discover she needed more stomach acid, not less. The medication keeping her sick was designed to do exactly that. Today we’re exposing the greatest medical deception in modern history, how a petroleum empire systematically destroyed natural healing wisdom turned medicine into a profit machine. And why the treatments, keeping millions sick were engineered that way from the beginning. This isn’t about conspiracy theories. This is a documented history that explains why you feel so lost about your own body’s needs welcome back to let’s talk wellness. Now the show where we uncover the root causes of chronic illness, explore cutting edge regenerative medicine, and empower you with the tools to heal. I’m Dr. Deb. And today we’re diving into how the Rockefeller Medical Empire systematically destroyed natural healing wisdom and replaced it with profit driven systems that keeps you dependent on treatments instead of achieving true health. If you or someone you love has been running to the doctor for every minor ailment, taking acid blockers that seem to make digestive problems worse, or feeling confused about basic body functions that our ancestors understood instinctively. This episode is for you. So, as usual, grab a cup of coffee, tea, or whatever helps you unwind. Settle in and let’s get started on your journey to reclaiming your health sovereignty all right. So here we are talking about the Rockefeller Medical Revolution. Now, what if your symptoms aren’t true diagnosis, but rather the predictable result of a medical system designed over a hundred years ago to create lifelong customers instead of healthy people. Now I learned this when I was in naturopathic school over 20 years ago. And it hasn’t been talked about a lot until recently. Recently. People are exposing the truth about what actually happened in our medical system. And today I want to take you back to the early 19 hundreds to understand how we lost the basic health wisdom that sustained humanity for thousands of years. Yes, I said that thousands of years. This isn’t conspiracy theory. This is documented history. That explains why you feel so lost when it comes to your own body’s needs. You know by the turn of the 20th century. According to meridian health Clinic’s documentation. Rockefeller controlled 90% of all petroleum refineries in America and through ownership of the Standard Oil Corporation. But Rockefeller saw an opportunity that went far beyond oil. He recognized that petrochemicals could be the foundation for a completely new medical system. And here’s what most people don’t know. Natural and herbal medicines were very popular in America during the early 19 hundreds. According to Staywell, Copper’s historical analysis, almost one half of medical colleges and doctors in America were practicing holistic medicine, using extensive knowledge from Europe and native American traditions. People understood that food was medicine, that the body had natural healing mechanisms, and that supporting these mechanisms was the key to health. But there was a problem with the Rockefeller’s business plan. Natural medicines couldn’t be patented. They couldn’t make a lot of money off of them, because they couldn’t hold a patent. Petrochemicals, however, could be patented, could be owned, and could be sold for high profits. So Rockefeller and Andrew Carnegie devised a systematic plan to eliminate natural medicine and replace it with petrochemical based pharmaceuticals and according to E. Richard Brown’s comprehensive academic documentation in Rockefeller, medicine men. Medicine, and capitalism in America. They employed the services of Abraham Flexner, who proceeded to visit and assess every single medical school in us and in Canada. Within a very short time of this development, medical schools all around the us began to collapse or consolidate. The numbers are staggering. By 1910 30 schools had merged, and 21 had closed their doors of the 166 medical colleges operating in 19 0, 4, a hundred 33 had survived by 1910 and a hundred 4 by 1915, 15 years later, only 76 schools of medicine existed in the Us. And they all followed the same curriculum. This wasn’t just about changing medical education. According to Staywell’s copper historical analysis. Rockefeller and Carnegie influenced insurance companies to stop covering holistic treatments. Medical professionals were trained in the new pharmaceutical model and natural solutions became outdated or forgotten. Not only that alternative healthcare practitioners who wanted to stay practicing in alternative medicine were imprisoned for doing so as documented by the potency number 710. The goal was clear, create a system where scientists would study how plants cure disease, identify which chemicals in the plants were effective and then recreate a similar but not identical chemical in the laboratory that would be patented. E. Richard Brown’s documents. The story of how a powerful professional elite gained virtual homogeny in the western theater of healing by effectively taking control of the ethos and practice of Western medicine. The result, according to the healthcare spending data, the United States now spends 17.6% of its Gdp on health care 4.9 trillion dollars in 2023, or 14,570 per person nearly twice as much as the average Oecd country. But it doesn’t focus on cure. But on symptoms, and thus creating recurring clients. This systematic destruction of natural medicine explains why today’s healthcare providers often seem baffled by simple questions about nutrition why they immediately reach for a prescription medication for minor ailments, and why so many people feel disconnected from their own body’s wisdom. We’ve been trained over 4 generations to believe that our bodies are broken, and that symptoms are diseases rather than messages, and that external interventions are always superior to supporting natural healing processes. But here’s what they couldn’t eliminate your body’s innate wisdom. Your digestive system still functions the same way it did a hundred years ago. Your immune system still follows the same patterns. The principles of nutrition, movement and stress management haven’t changed. We’ve just forgotten how to listen and respond. We’re gonna take a small break here and hear from our sponsor. When we come back. We’re gonna talk about the acid reflux deception, and why your cure is making you sicker, so don’t go away all right, welcome back. So I want to give you a perfect example of how Rockefeller medicine has turned natural body wisdom upside down, the treatment of acid, reflux, and heartburn. Every single day in my practice I see patients who’ve been taking acid blocker medications, proton pump inhibitors like prilosec nexium or prevacid for years, not for weeks, years, and sometimes even decades. They come to me because their digestive problems are getting worse, not better. They have bloating and gas and nutrition deficiencies. And we’re seeing many more increased food sensitivities. And here’s what’s happening in the Us. Most people often attribute their digestive problems to too much stomach acid. And they use medications to suppress the stomach acid, but, in fact symptoms of chronic acid, reflux, heartburn, or gerd, can also be caused by too little stomach acid, a condition called hyper. Sorry hypochlorhydria normal stomach acid has a Ph level of one to 2, which is highly acidic. Hydrochloric acid plays an important role in your digestion and your immunity. It helps to break down proteins and absorb essential nutrients, and it helps control viruses and bacteria that might otherwise infect your stomach. But here’s the crucial part that most people don’t understand, and, according to Cleveland clinic, your stomach secretes lower amounts of hydrochloric acid. As you age. Hypochlorhydria is more common in people over the age of 40, and even more common over the age of 65. Webmd states that the stomach acid can produce less acid as a result of aging and being 65 or older is a risk factor for developing hypochlorhydria. We’ve been treating this in my practice for a long time. It’s 1 of the main foundations that we learn as naturopathic practitioners and as naturopathic doctors, and there are times where people need these medications, but they were designed to be used short term not long term in a 2,013 review published in Medical News today, they found that hypochlorhydria is the main change in the stomach acid of older adults. and when you have hypochlorydria, poor digestion from the lack of stomach, acid can create gas bubbles that rise into your esophagus or throat, carrying stomach acid with them. You experience heartburn and assume that you have too much acid. So you take acid blockers which makes the underlying problem worse. Now, here’s something that will shock you. PPI’s protein pump inhibitors were originally studied and approved by the FDA for short-term use only according to research published in us pharmacists, most cases of peptic ulcers resolve in 6 to 8 weeks with PPI therapy, which is what these medications were created for. Originally the American family physician reports that for erosive esophagitis. Omeprazole is indicated for short term 4 to 8 weeks. That’s it. Treatment and healing and done if needed. An additional 4 to 8 weeks of therapy may be considered and the University of Minnesota College of Pharmacy, States. Guidelines recommended a treatment duration of 8 weeks with standard once a day dosing for a PPI for Gerd. The Canadian family physician, published guidelines where a team of healthcare professionals recommended prescribing Ppis in adults who suffer from heartburn and who have completed a minimum treatment of 4 weeks in which symptoms were relieved. Yet people are taking these medications for years, even decades far beyond their intended duration of use and a study published in Pmc. Found that the threshold for defining long-term PPI use varied from 2 weeks to 7 years of PPI use. But the most common definition was greater than one year or 6 months, according to the research in clinical context, use of Ppis for more than 8 weeks could be reasonably defined as long-term use. Now let’s talk about what these acid blocker medications are actually doing to your body when used. Long term. The research on long term PPI use is absolutely alarming. According to the comprehensive review published in pubmed central Pmc. Long-term use of ppis have been associated with serious adverse effects, including kidney disease, cardiovascular disease fractures because you’re not absorbing your nutrients, and you’re being depleted. Infections, including C. Diff pneumonia, micronutrient deficiencies and hypomagnesium a low level of magnesium anemia, vitamin, b, deficiency, hypocalcemia, low calcium, low potassium. and even cancers, including gastric cancer, pancreatic cancer, colorectal cancer. And hepatic cancer and we are seeing all of these cancers on a rise, and we are now linking them back to some of these medications. Mayo clinic proceedings published research showing that recent studies regarding long-term use of PPI medication have noted potential adverse effects, including risks of fracture, pneumonia, C diff, which is a diarrhea. It’s a bacteria, low magnesium, low b 12 chronic kidney disease and even dementia. And a 2024 study published in nature communications, analyzing over 2 million participants from 5 cohorts found that PPI use correlated with increased risk of 15 leading global diseases, such as ischemic heart disease. Diabetes, respiratory infections, chronic kidney disease. And these associations showed dose response relationships and consistency across different PPI types. Now think about this. You take a medication for heartburn that was designed for 4 to 8 weeks of use, and when used long term, it actually increases your risk of life, threatening infections, kidney disease, and dementia. This is the predictable result of suppressing a natural body function that exists for important reasons. Hci plays a key role in many physiological processes. It triggers, intestinal hormones, prepares folate and B 12 for absorption, and it’s essential for absorption of minerals, including calcium, magnesium, potassium, zinc, and iron. And when you block acid production, you create a cascade of nutritional deficiencies and immune system problems that often manifest as seemingly unrelated health issues. So what’s the natural approach? Instead of suppressing stomach acid, we need to support healthy acid production and address the root cause of reflux healthcare. Providers may prescribe hcl supplements like betaine, hydrochloric acid. Bhcl is what it’s called. Sometimes it’s called betaine it’s often combined with enzymes like pepsin or amylase or lipase, and it’s used to treat hydrochloric acid deficiency, hypochlorhydria. These supplements can help your digestion and sometimes help your stomach acid gradually return back to normal levels where you may not need to use them all the time. Simple strategies include consuming protein at the beginning of the meal to stimulate Hcl production, consume fluids separately at least 30 min away from meals, if you can, and address the underlying cause like chronic stress and H. Pylori infections. This is such a sore subject for me. So many people walk around with an H. Pylori infection. It’s a bacterial infection in the stomach that can cause stomach ulcers, causes a lot of stomach pain and burning. and nobody is treating the infection. It’s a bacterial infection. We don’t treat this anymore with antibiotics or antimicrobials. We treat it with Ppis. But, Ppis don’t fix the problem. You have to get rid of the bacteria once the bacteria is gone, the gut lining can heal. Now it is a common bacteria. It can reoccur quite frequently. It’s highly contagious, so you can pick it up from other people, and it may need multiple courses of treatment over a person’s lifetime. But you’re actually treating the problem. You’re getting rid of the bacteria that’s creating the issue instead of suppressing the acid. That’s not fixing the bacteria which then leads to a whole host of other problems that we just talked about. There are natural approaches to increase stomach acid, including addressing zinc deficiency. And since the stomach uses zinc to produce Hcl. Taking probiotics to help support healthy gut bacteria and using digestive bitters before meals can be really helpful. This is exactly what I mean about reclaiming the body’s wisdom. Instead of suppressing natural functions, we support them instead of creating drug dependency, we restore normal physiology. Instead of treating symptoms indefinitely, we address the root cause and help the body heal itself. In many cultures. Bitters is a common thing to use before or after a meal. But yet in the American culture we don’t do that anymore. We’ve not passed on that tradition. So very few people understand how to use bitters, or what bitters are, or why they’re important. And these basic things that can be used in your food and cooking and taking could replace thousands of dollars of medication that you don’t really need. That can create many more problems along the way. Now, why does your doctor know nothing about nutrition. Well, I want to address something that might shock you all. The reason your doctor seems baffled when you ask about nutrition isn’t because they’re not intelligent. It’s because they literally never learned this in medical school statistics on nutritional education in medical schools are staggering and help explain why we have such a health literacy crisis in America. According to recent research published in multiple academic journals, only 27% of Us. Medical schools actually offer students. The recommended 25 h of nutritional training across 4 years of medical school. That means 73% of the medical schools don’t even meet the minimum standards set in 1985. But wait, it gets worse. A 2021 survey of medical schools in the Us. And the Uk. Found that most students receive an average of only 11 h of nutritional training throughout their entire medical program. and another recent study showed that in 2023 a survey of more than a thousand Us. Medical students. About 58% of these respondents said they received no formal nutritional education while in medical school. For 4 years those who did averaged only 3 h. I’m going to say this again because it’s it’s huge 3 h of nutritional education per year. So let me put this in perspective during 4 years of medical school most students spend fewer than 20 h on nutrition that’s completely disproportionate to its health benefits for patients to compare. They’ll spend hundreds of hours learning about pharmaceutical interventions, but virtually no time learning how food affects health and disease. Now, could this be? Why, when we talk about nutrition to lower cholesterol levels or control your diabetes, they blow you off, and they don’t answer you. It’s because they don’t understand. But yet what they’ll say is, people won’t change their diet. That’s why you have to take medication. That’s not true. I will tell you. I work with people every single day who are willing to change their diet. They’re just confused by all the information that’s out there today about nutrition. And what diet is the right diet to follow? Do I do, Paleo? Do I do? Aip? Do I do carnivore? Do I do, Keto? Do I do? Low carb? There’s so many diets out there today? It’s confusing people. So I digress. But let’s go back. So here’s the kicker. The limited time medical students do spend on nutrition office often focuses on nutrients think proteins and carbohydrates rather than training in topics such as motivational interviewing or meal planning, and as one Stanford researcher noted, we physicians often sound like chemists rather than counselors who can speak with patients about diet. Isn’t that true? We can speak super high level up here, but we can’t talk basics about nutrition. And this explains why only 14% of the physicians believe they were adequately trained in nutritional counseling. Once they entered practice and without foundational concepts of nutrition in undergrad work. Graduate medical education unsurprisingly falls short of meeting patients, needs for nutritional guidance in clinical practice, and meanwhile diet, sensitive chronic diseases continue to escalate. Although they are largely preventable and treatable by nutritional therapies and dietary. Lifestyle changes. Now think about this. Diet. Related diseases are the number one cause of death in the Us. The number one cause. Yet many doctors receive little to no nutritional education in medical school, and according to current health statistics from 2017 to march of 2020. Obesity prevalence was 19.7% among us children and adolescents affecting approximately 14.7 million young people. About 352,000 Americans, under the age of 20, have been diagnosed with diabetes. Let me say this again, because these numbers are astounding to me. 352,000 Americans, under the age of 20, have been diagnosed with diabetes with 5,300 youth diagnosed with type, 2 diabetes annually. Yet the very professionals we turn to for health. Guidance were never taught how food affects these conditions and what drug has come to the rescue Glp. One S. Ozempic wegovy. They’re great for weight loss. They’re great for treating diabetes. But why are they here? Well, these numbers are. Why, they’re here. This is staggering to put 352,000 Americans under the age of 20 on a glp, one that they’re going to be on for the rest of their lives at a minimum of $1,200 per month. All we have to do is do the math, you guys, and we can see exactly what’s happening to our country, and who is getting rich, and who is getting the short end of the stick. You’ve become a moneymaker to the pharmaceutical industry because nobody has taught you how to eat properly, how to live, how to have a healthy lifestyle, and how to prevent disease, or how to actually reverse type 2 diabetes, because it’s reversible in many cases, especially young people. And we do none of that. All we do is prescribe medications. Metformin. Glp, one for the rest of your life from 20 years old to 75, or 80, you’re going to be taking medications that are making the pharmaceutical companies more wealth and creating a disease on top of a disease on top of a disease. These deficiencies in nutritional education happen at all levels of medical training, and there’s been little improvement, despite decades of calls for reform. In 1985, the National Academy of Sciences report that they recommended at least 25 h of nutritional education in medical school. But a 2015 study showed only 29% of medical schools met this goal, and a 2023 study suggests the problem has become even worse. Only 7.8% of medical students reported 20 or more hours of nutritional education across all 4 years of medical school. This systemic lack of nutrition, nutritional education has been attributed to several factors a dearth of qualified instructors for nutritional courses, since most physicians do not understand nutrition well enough to teach it competition for curriculum time, with schools focusing on pharmaceutical interventions rather than lifestyle medicine and a lack of external incentives that support schools, teaching nutrition. And ironically, many medical schools are part of universities that have nutrition departments with Phd. Trained professors who could fill this gap by teaching nutrition in medical schools but those classes are often taught by physicians who may not have adequate nutritional training themselves. This explains so much about what I see in my practice. Patients come to me confused and frustrated because their primary care doctors can’t answer basic questions about how food affects their health conditions. And these doctors aren’t incompetent. They simply were never taught this information. And the result is that these physicians graduate, knowing how to prescribe medications for diabetes, but not how dietary changes can prevent or reverse it. They can treat high blood pressure with pharmaceuticals, but they may not know that specific nutritional approaches can be equally or more effective. This isn’t the doctor’s fault. It’s the predictable result of medical education systems that was deliberately designed to focus on patentable treatments rather than natural healing approaches. And remember this traces back to the Rockefeller influence on medical education. You can’t patent an apple or a vegetable. But you can patent a drug now. Why can’t we trust most medical studies? Well this just gets even better. I need to address something that’s crucial for you to understand as you navigate health information. Why so much of the medical research you hear about in the news is biased, and why peer Review isn’t the gold standard of truth you’ve been told it is. The corruption in medical research by pharmaceutical companies is not a conspiracy theory. It’s well documented scientific fact, according to research, published in frontiers, in research, metrics and analytics. When pharmaceutical and other companies sponsor research, there is a bias. A systematic tendency towards results serving their interests. But the bias is not seen in the formal factors routinely associated with low quality science. A Cochrane Review analyzed 75 studies of the association between industry, funding, and trial results, and these authors concluded that trials funded by a drug or device company were more likely to have positive conclusions and statistically significant results, and that this association could not be explained by differences in risk of bias between industry and non-industry funded trials. So think about that. According to the Cochrane collaboration, industry funding itself should be considered a standard risk of bias, a factor in clinical trials. Studies published in science and engineering ethics show that industry supported research is much more likely to yield positive outcomes than research with any other sponsorship. And here’s how the bias gets introduced through choice of compartor agents, multiple publications of positive trials and non-publication of negative trials reinterpreting data submitted to regulatory agencies, discordance between results and conclusions, conflict of interest leading to more positive conclusions, ghostwriting and the use of seating trials. Research, published in the American Journal of Medicine. Found that a result favorable to drug study was reported by all industry, supported studies compared with two-thirds of studies, not industry, supported all industry, supported studies showed favorable results. That’s not science that’s marketing, masquerading as research. And according to research, published in sciencedirect the peer review system which we’re told ensures quality. Science has a major limitation. It has proved to be unable to deal with conflicts of interest, especially in big science contexts where prestigious scientists may have similar biases and conflicts of interest are widely shared among peer reviewers. Even government funded research can have conflicts of interest. Research published in pubmed States that there are significant benefits to authors and investigators in participating in government funded research and to journals in publishing it, which creates potentially biased information that are rarely acknowledged. And, according to research, published in frontiers in research, metrics, and analytics, the pharmaceutical industry has essentially co-opted medical knowledge systems for their particular interests. Using its very substantial resources. Pharmaceutical companies take their own research and smoothly integrate it into medical science. Taking advantage of the legitimacy of medical institutions. And this corruption means that much of what passes for medical science is actually influenced by commercial interests rather than pursuant of truth. Research published in Pmc. Shows that industry funding affects the results of clinical trials in predictable directions, serving the interests of the funders rather than the patients. So where can we get this reliable, unbiased Health information, because this is critically important, because your health decisions should be based on the best available evidence, not marketing disguised as science. And so here are some sources that I recommend for trustworthy health and nutritional information. They’re independent academic sources. According to Harvard Chan School of public health their nutritional, sourced, implicitly states their content is free from industry, influence, or support. The Linus Pauling Institute, Micronutrient Information Center at Oregon State University, which, according to the Glendale Community college Research Guide provides scientifically accurate information about vitamins, minerals, and other dietary factors. This Institute has been around for decades. I’ve used it a lot. I’ve gotten a lot of great information from them. Very, very trustworthy. According to the Glendale Community College of Nutrition Resource guide Tufts, University of Human Nutritional Research Center on aging is one of 6 human nutrition research centers supported by the United States Department of Agriculture, the Usda. Their peer reviewed journals with strong editorial independence though you must still check funding resources. And how do you evaluate this information? Online? Well, according to medlineplus and various health literacy guides when evaluating health information medical schools and large professional or nonprofit organizations are generally reliable sources, but remember, it is tainted by the Rockefeller method. So, for example, the American College of cardiology. Excuse me. Professional organization and the American Heart Institute a nonprofit are both reliable sources. Sorry about that of information on heart health and watch out for ads designed to look like neutral health information. If the site is funded by ads they should be clearly marked as advertisements. Excuse me, I guess I’m talking just a little too much now. So when the fear of medicine becomes deadly. Now, I want to address something critically important that often gets lost in conversations about health, sovereignty, and questioning the medical establishment. And while I’ve spent most of this episode explaining how the Rockefeller medical system has created dependency and suppressed natural healing wisdom. There’s a dangerous pendulum swing happening that I see in my practice. People becoming so fearful of pharmaceutical interventions that they refuse lifesaving treatments when they’re genuinely needed. This is where balance and clinical judgment become absolutely essential. Yes, we need to reclaim our basic health literacy and reduce our dependency on unnecessary medical interventions. But there are serious bacterial infections that require immediate antibiotic treatment, and the consequences of avoiding treatment can be devastating or even fatal. So let me share some examples from research that illustrate when antibiotic fear becomes dangerous. Let’s talk about Lyme disease, and when natural approaches might not be enough. The International Lyme Disease Association ilads has conducted extensive research on chronic lyme disease, and their findings are sobering. Ileds defines chronic lyme disease as a multi-system illness that results from an active and ongoing infection of pathogenic members of the Borrelia Brdorferi complex. And, according to ilads research published in their treatment guidelines, the consequences of untreated persistent lyme infection far outweigh the potential consequences of long-term antibiotic therapy in well-designed trials of antibiotic retreatment in patients with severe fatigue, 64% in the treatment arm obtained clinically significant and sustained benefit from additional antibiotic therapy. Ilas emphasizes that cases of chronic borrelia require individualized treatment plans, and when necessary antibiotic therapy should be extended their research demonstrates that 20 days of prophylactic antibiotic treatment may be highly effective for preventing the onset of lyme disease. After known tick bites and patients with early Lyme disease may be best served by receiving 4 to 6 weeks of antibiotic therapy. Research published in Pmc. Shows that patients with untreated infections may go on to develop chronic, debilitating, multisystem illnesses that is difficult to manage, and numerous studies have documented persistent Borrelia, burgdorferi infection in patients with persistent symptoms of neurological lyme disease following short course. Antibiotic treatment and animal models have demonstrated that short course. Antibiotic therapy may fail to eradicate lyme spirochetes short course is a 1 day. One pill treatment of doxycycline. Or less than 20 days of antibiotics, is considered a short course. It’s not long enough to kill the bacteria. The bacteria’s life cycle is about 21 days, so if you don’t treat the infection long enough, the likelihood of that infection returning is significant. They’ve also done studies in the petri dish, where they show doxycycline being put into a petri dish with active lyme and doxycycline does not kill the infection, it just slows the replication of it. Therefore, using only doxycycline, which is common practice in lyme disease may not completely eradicate that infection for you. So let’s talk about another life threatening emergency. C. Diff clostridia difficile infection, which represents another example where antibiotic treatment is absolutely essential, despite the fact that C diff itself is often triggered by antibiotic use. According to Cleveland clinic C. Diff is estimated to cause almost half a million infections in the United States each year, with 500,000 infections, causing 15,000 deaths each year. Studies reported by Pmc. Found thirty-day Cdi. Mortality rates ranging from 6 to 11% and hospitalized Cdi patients have significantly increased the risk of mortality and complications. Research published in Pmc shows that 16.5% of Cdi patients experience sepsis and that this increases with reoccurrences 27.3% of patients with their 1st reoccurrence experience sepsis. While 33.1% with 2 reoccurrences and 43.2% with 3 or more reoccurrences. Mortality associated with sepsis is very high within hospital 30 days and 12 month mortality rates of 24%, 30% and 58% respectively. According to the Cdc treatment for C diff infection usually involves taking a specific antibiotic, such as vancomycin for at least 10 days, and while this seems counterintuitive, treating an antibiotic associated infection with more antibiotics. It’s often lifesaving. Now let’s talk about preventing devastating complications. Strep throat infections. Provide perhaps the clearest example of when antibiotic treatment prevents serious long-term consequences, and, according to Mayo clinic, if untreated strep throat can cause complications such as kidney inflammation and rheumatic fever. Rheumatic fever can lead to painful and inflamed joints, and a specific type of rash of heart valve damage. We also know that strep can cause pans pandas, which is a systemic infection, often causing problems with severe Ocd. And anxiety and affecting mostly young people. The research is unambiguous. According to the Cleveland clinic. Rheumatic fever is a rare complication of untreated strep, throat, or scarlet fever that most commonly affects children and teens, and in severe cases it can lead to serious health problems that can affect your child’s heart. Joints and organs. And research also shows that the rate of development of rheumatic fever in individuals with untreated strep infections is estimated to be 3%. The incidence of reoccurrence with a subsequent untreated infection is substantially greater. About 50% the rate of development is far lower in individuals who have received antibiotic treatment. And according to the World health organization, rheumatic heart disease results from the inflammation and scarring of the heart valves caused by rheumatic fever, and if rheumatic fever is not treated promptly, rheumatic heart disease may occur, and rheumatic heart disease weakens the valves between the chambers of the heart, and severe rheumatic heart disease can require heart surgery and result in death. The who states that rheumatic heart disease remains the leading cause of maternal cardiac complications during pregnancy. And additionally, according to the National Kidney foundation. After your child has either had throat or skin strep infection, they can develop post strep glomerial nephritis. The Strep bacteria travels to the kidneys and makes the filtering units of the kidneys inflamed, causing the kidneys to be able to unable or less able to fill and filter urine. This can develop one to 2 weeks after an untreated throat infection, or 3 to 4 weeks after an untreated skin infection. We need to find balance. And here’s what I want you to understand. Questioning the medical establishment and developing health literacy doesn’t mean rejecting all medical interventions. It means developing the wisdom to know when they’re necessary and lifesaving versus when they’re unnecessary and potentially harmful. When I see patients with confirmed lyme disease, serious strep infections or life. Threatening conditions like C diff. I don’t hesitate to recommend appropriate therapy but I also work to support their overall health address, root causes, protect and restore their gut microbiome and help them recover their natural resilience. The goal isn’t to avoid all medical interventions. It’s to use them wisely when truly needed, while simultaneously supporting your body’s inherent healing capacity and addressing the lifestyle factors that created the vulnerability. In the 1st place. All of this can be extremely overwhelming, and it can be frightening to understand or learn. But remember, the power that you have is knowledge. The more you learn about what’s actually happening in your health, in understanding nutrition. in learning what your body wants to be fed, and how it feels, and working with practitioners who are holistic in nature, natural, integrative, functional, whatever we want to call that these days. The more you can learn from them, the more control you have over your own health and what I would urge you to do is to teach your children what you’re learning. Teach them how to live a healthy lifestyle, teach them how to keep a clean environment. This is how we take back our own health. So thank you for joining me today on, let’s talk wellness. Now, if this episode resonated with you. Please share it with someone who could benefit from understanding how the Rockefeller medical system has shaped our approach to health, and how to reclaim your body’s wisdom while using medical care appropriately when truly needed. Remember, wellness isn’t just about feeling good. It’s about understanding your body, trusting its wisdom, supporting its natural healing capacity, and knowing when to seek appropriate medical intervention. If you’re ready to explore how functional medicine can help you develop this deeper health knowledge while addressing root causes rather than just managing symptoms. You can get more information from serenityhealthcarecenter.com, or reach out directly to us through our social media channels until next time. I’m Dr. Dab, reminding you that your body is your wisest teacher. Learn to listen, trust the process, use medical care wisely when needed, and take care of your body, mind, and spirit. Be well, and we’ll see you on the next episode.The post Episode 250 -The Great Medical Deception first appeared on Let's Talk Wellness Now.

Aging sits at the intersection of biology, behavior, and belief. While time moves forward on its own and how the body responds depends on the choices made.In this episode, Dr. Stephen Petteruti takes a clear-eyed look at metformin and its role in anti-aging. He explains why this decades-old diabetes medication drew attention for longevity and how it affects metabolism, inflammation, and cellular energy regulation.Rather than offering blanket answers, Dr. Stephen outlines who may benefit from metformin and who should approach it cautiously. He addresses real trade-offs, including digestive effects, muscle considerations in aging adults, and the importance of medical oversight.For those serious about aging well, this episode provides a grounded framework. Tune in NOW: Should You Take Metformin For Anti-aging?Enjoy the podcast? Subscribe and leave a 5-star review on your favorite platforms.Dr. Stephen Petteruti is a leading Functional Medicine Physician dedicated to enhancing vitality by addressing health at a cellular level. Combining the best of conventional medicine with advancements in cellular biology, he offers a patient-centered approach through his practice, Intellectual Medicine 120. A seasoned speaker and educator, he has lectured at prestigious conferences like A4M and ACAM, sharing his expertise on anti-aging. His innovative methods include concierge medicine and non-invasive anti-aging treatments, empowering patients to live longer, healthier lives.Website: www.intellectualmedicine.com Website: https://www.theprostateprotocol.com/ YouTube: https://www.youtube.com/@intellectualmedicine LinkedIn: https://www.linkedin.com/in/drstephenpetteruti/ Instagram: instagram.com/intellectualmedine Consultation: https://www.theprostateprotocol.com/book-a-consultation Store: https://www.theprostateprotocol.com/store Community: https://www.theprostateprotocol.com/products/communities/v2/fightcancerlikeaman/home    Disclaimer:  The content presented in this video reflects the opinions and clinical experience of Dr. Stephen Petteruti and is intended for informational and educational purposes only. It is not medical advice and should not be used as a substitute for professional diagnosis, treatment, or guidance from your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your health regimen or treatment plan.Produced by https://www.BroadcastYourAuthority.com 

What do you think of thiamine as a treatment for Parkinson's?Is there a natural thyroid medicine you recommend that is not pork-derived?Please discuss the COVID-19 vaccine and cardiology issuesCan you help my granddaughter with guttate psoriasis?

Holiday Stress tops tax season stressWhat would Dr. Hoffman say?Is berberine truly efficacious?My doctor recommends I drink alcohol to reduce stress and improve circulation

Metformin is a widely prescribed Type 2 diabetes drug that works by lowering liver glucose production and improve insulin sensitivity A 16-week Rutgers trial in 72 adults found that metformin dulled exercise benefits, reducing the usual improvements in aerobic fitness Long-term risks for prolonged metformin use include vitamin B12 deficiency, rare lactic acidosis, and hypoglycemia Skipping breakfast, not getting enough sleep, consuming too much alcohol, and social isolation can greatly disturb glucose regulation and increase the risk of developing diabetes over time Lifestyle strategies such as consistent movement, and a bioenergetic, nutrient-dense diet can support insulin sensitivity. Berberine may also help to slowly wean you off metformin medication

In this Huberman Lab Essentials episode, my guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health. We explain how to improve hormone levels across the lifespan in both men and women using behavioral, nutritional and exercise-based tools. We also discuss common clinical topics, including hormone testing, PCOS, hair loss, testosterone replacement therapy (TRT) and peptides, focusing on potential benefits, tradeoffs and risks. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui: https://mauinuivenison.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Kyle Gillett (00:00:36) Hormone Health; Women vs Men, Tool: Hormone Testing (00:02:35) Tool: Big 6 Lifestyle Pillars to Optimize Hormone Health (00:04:32) Sponsor: AG1 (00:06:17) Diet, Individualization; Bloodwork & Frequency (00:07:20) Exercise, Zone 2 Cardio; Caloric Restriction (00:08:36) Intermittent Fasting, Growth Hormone, IGF-1 (00:11:05) Hormones & Sleep, Growth Hormone, Menopause, Andropause, TRT (00:13:28) Testosterone & Women, SHGB (00:15:19) Sponsor: Maui Nui (00:16:34) Dihydrotestosterone (DHT), Androgens; Turmeric & Black Pepper; Hair Loss (00:19:47) Polycystic Ovarian Syndrome (PCOS), Symptoms, Metformin, Inositol (00:23:13) Cannabis, Alcohol, Testosterone (00:24:48) Males & Testosterone, TRT, Prostate Cancer (00:26:04) Prolactin, Dopamine "Wave Pool", Tool: Casein & Gluten (00:27:23) Sponsor: Function (00:29:03) Social Relationships & Hormones, Tool: Planning for Crisis (00:31:02) Peptides, Growth Hormone & Risk; BPC 157, Sourcing & LPS (00:36:42) Melanotan, Uses & Risks (00:38:45) Spiritual Health, Interdisciplinary Health Integration (00:41:23) Caffeine & Hormones, Sleep; Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to the emDOCs.net podcast! Join us as we review our high-yield posts from our website emDOCs.net.Today on the emDOCs cast with Brit Long (@long_brit), we cover metformin toxicity.To continue to make this a worthwhile podcast for you to listen to, we appreciate any feedback and comments you may have for us. Please let us know!Subscribe to the podcast on one of the many platforms below:Apple iTunesSpotifyGoogle Play 

A new study out of India shows a bit of crossover between sarcoidosis and lung cancer.  In this episode of the FSR Sarc Fighter podcast, I'll take a look at the study and what it reveals — including a new drug, Metformin, previously used to treat Type 2 Diabetes, that may show promise based on the study's findings.  For what it's worth, I'll also share the terrors of surgery for my ruptured Achilles.       Show Notes:  Donate to FSR: https://stopsarcoidosis.rallybound.org/gratitude-and-giving-2025 FSR Biomarker Summit: https://www.stopsarcoidosis.org/fsr-convenes-global-leaders-for-landmark-clinic-alliance-meeting-and-sarcoidosis-biomarker-summit/ Sarcoidosis News Study from India: https://sarcoidosisnews.com/news/new-genetic-clues-connect-sarcoidosis-lung-cancer-risk More from FSR: https://www.stopsarcoidosis.org/fsr-receives-confirmation-from-the-department-of-labor-ensuring-patient-access-to-fmla-for-participation-in-clinical-trials/ MORE FROM JOHN: Cycling with Sarcoidosis http://carlinthecyclist.com/category/cycling-with-sarcoidosis/ Do you like the official song for the Sarc Fighter podcast?  It's also an FSR fundraiser! If you would like to donate in honor of Mark Steier and the song, Zombie, Here is a link to his KISS account.  (Kick In to Stop Sarcoidosis)  100-percent of the money goes to the Foundation.  https://stopsarcoidosis.rallybound.org/MarkSteier The Foundation for Sarcoidosis Research https://www.stopsarcoidosis.org/ Donate to my KISS (Kick In to Stop Sarcoidosis) fund for FSR  https://stopsarcoidosis.rallybound.org/JohnCarlinVsSarcoidosis?fbclid=IwAR1g2ap1i1NCp6bQOYEFwOELdNEeclFmmLLcQQOQX_Awub1oe9bcEjK9P1E My story on Television https://www.stopsarcoidosis.org/news-anchor-sarcoidosis/ email me  carlinagency@gmail.com #sarcoidosis #sarcoidosisawareness #fmla #fmlaclarification #metformin  

Podcast Family, we have covered PCOS on this show many times in the past; and yet- again, there is new information! A new publication from AJOG (Gray journal) describes a new meta-analysis on preconception/continued metformin use in the first trimester. Is this helpful? How does this contrast with the 2023 international guidance update on PCOS? Listen in for details. 1. ASRM: Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome (2023)2. Cheshire J, Garg A, Smith P, Devall AJ, Coomarasamy A, Dhillon-Smith RK. Preconception and first-trimester metformin on pregnancy outcomes in women with polycystic ovary syndrome: a systematic review and meta-analysis. Am J Obstet Gynecol. 2025 Dec;233(6):530-547.e8. doi: 10.1016/j.ajog.2025.05.038. Epub 2025 Jun 3. PMID: 40473092.3. Løvvik TS, Carlsen SM, Salvesen Ø, et al. Use of Metformin to Treat Pregnant Women With Polycystic Ovary Syndrome (PregMet2): A Randomised, Double-Blind, Placebo-Controlled Trial. The Lancet. Diabetes & Endocrinology. 2019;7(4):256-266. doi:10.1016/S2213-8587(19)30002-6.4. Teede HJ, Tay CT, Laven J, et al. Recommendations From the 2023 International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertility and Sterility. 2023;120(4):767-793. doi:10.1016/j.fertnstert.2023.07.025.

What are your thoughts on the benefits of magnesium threonate?Is creatine helpful in building bone strength in osteoporosis?What are your thoughts on the REMS ultrasound to diagnose bone mineral density status?What should I do about my PSA, which appears to be trending upward?  Are my diabetes meds causing erectile dysfunction?Does maltodextrin spike blood glucose tremendously?

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The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 – Intro00:02:28 – Remote vs. In-Person Peaking00:03:50 – Data Driven Coaching00:06:13 – First Cycle Philosophy00:09:31 – Post-Show Buffer Protocol00:11:02 – The Estrogen Myth00:14:14 – The Calcium Score Imperative00:15:59 – The Vitamin D3 Danger00:17:49 – Death by Potassium00:20:23 – Halo vs. Superdrol00:27:37 – Thyroid Tapering00:30:59 – Western Medicine vs. Bodybuilding00:33:16 – The Rebound Phase00:37:42 – Female Androgen Health Effects00:44:31 – Metformin vs. Berberine00:48:18 – Myostatin & The Future of PEDs00:52:23 – Training is what matters most00:58:00 – Fixing Back Training01:05:26 – From Dietitian to Super Coach01:14:32 – Insulin Sensitivity & Gut Health01:23:03 – Peak Week Glucose & GI Health Management01:31:01 – The Dyazide Strategy01:41:02 – The GLP-1 Trap01:54:31 – Classic Physique Weight Cuts01:56:14 – Stanimal Case Study02:09:48 – Insulin & HGH Synergy02:15:42 – Why Modern Bodybuilding is Soft02:21:35 – Designing the Offseason Cycle02:37:05 – Waist Control Secrets02:40:33 – Nick Walker & Coaching02:43:27 – Female PED Safety02:52:36 – Fertility & Sperm Banking02:55:40 – The Final Message

If you want to get leaner and live longer check out https://milliondollarbodylabs.com   Is diabetes truly a life sentence, or can you reverse it without relying on drugs like Metformin or Ozempic?   I talked with Chris Reade, who discovered a serious health condition after a life insurance exam. His A1C went from normal to a high 9.1 in 10 months because of visceral fat around his pancreas. Doctors told him this disease was progressive and incurable, but Chris refused that sentence. He researched and found a simple strategy focused on using soluble fiber to control blood sugar spikes. This method forces weight loss naturally by providing bulk, reducing hunger, and mitigating the effect of sugar. His approach involves practical, everyday systems like habit stacking and focusing on food volume to give control back to the individual.   Key Takeaways Type 2 diabetes is caused by the accumulation of visceral fat (more than a gram or two) on the pancreas, which hinders its function. It has been known since the 1970s that you can absolutely reverse diabetes. Losing more than 10% of your body weight causes the body to pull fat off the pancreas, leading to the reversal of Type 2 diabetes roughly 80% of the time. Soluble fiber, found in foods like broccoli, Brussels sprouts, oatmeal, and chickpeas, slows digestion and absorbs sugar, mitigating blood sugar spikes. By focusing heavily on soluble fiber, you feel very full all the time, which is a key mechanism for effortless weight loss and managing cravings. Performing even a small amount of exercise, such as two to five minutes of walking immediately after a meal, can knock blood sugar down by up to 25%. The current medical model for treating diabetes in the U.S. is structured to promote dependency on medication, making diabetes prevention and remission less of a focus.   Resources Website: https://www.beatingdiabetes.us Book: Beating Diabetes by Chris Reade. https://www.beatingdiabetes.us/the-book Instagram: @beatingdiabetesus https://www.instagram.com/beatingdiabetesus LinkedIn: https://www.linkedin.com/company/beatingdiabetes/   Nate Palmer: The founder of The Million Dollar Body and author of "The Million Dollar Body Method", Nate has been coaching for over 15 years and has worked personally with over 1,000 clients. Website: https://milliondollarbodylabs.com/ Book: The Million Dollar Body Method Lean Energy Stack: https://milliondollarbodylabs.com/pages/lean Instagram: @_milliondollarbody  

My guest is Dr. Thaïs Aliabadi, MD, board-certified OB/GYN, surgeon and leading expert in women's health. We discuss polycystic ovary syndrome (PCOS) and endometriosis, two very common yet frequently undiagnosed causes of female infertility. Dr. Aliabadi explains the symptoms, underlying causes and evidence-based treatments for both conditions, including supplement and lifestyle interventions. We also discuss breast cancer risk and screening, pregnancy, perimenopause and menopause, and the hormone tests that women should request. This conversation offers empowering, potentially life-changing information for women of all ages to take control of their hormone, reproductive and overall health. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman Lingo: https://hellolingo.com/huberman Our Place: https://fromourplace.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00 Thaïs Aliabadi 02:56 Why Endometriosis & Polycystic Ovary Syndrome (PCOS) Go Undiagnosed 08:16 Infertility, Tool: Early Screening 10:54 Sponsors: Lingo & Our Place 14:07 Women's Health Education Gap 15:24 PCOS Overview: Symptoms, Diagnosis, AMH, Disordered Eating 21:28 Irregular Periods, Teenage PCOS Diagnosis 24:36 Diagnosis, Pelvic Ultrasound; PCOS Naming 27:49 Thinning Hair & Acne; 4 PCOS Phenotypes; Mood & Treatment 35:54 Underlying Pillars of PCOS; HPA Axis, Androgens, Menstruation & Ovulation 40:30 Insulin Resistance & PCOS, Visceral Fat & Inflammation 46:30 Sponsors: AGZ by AG1 & Joovv 49:10 PCOS, Chronic Inflammation, Genetics & Lifestyle; Mood 52:31 PCOS, Fertility, Freezing Eggs, Tool: Egg Count & AMH Range By Age 58:34 Women's Health Education, AI, Clinicians; Cataracts Analogy 1:01:20 Stress; PCOS Treatment, Birth Control, Insulin Resistance & Metformin 1:06:44 PCOS Risk Calculator, Supplements, Lifestyle Factors; GLP-1s 1:12:32 Berberine, Metformin; GLP-1s, Food Anxiety & Alcohol 1:19:13 PCOS Prescriptions & Fertility; PCOS Co-Occurrence with Endometriosis 1:21:56 Sponsor: LMNT 1:23:16 PCOS Treatment, Freezing Eggs, Egg Quality; Advocate For Your Health 1:32:02 PCOS Key Takeaways: Symptoms, Tests, Supplements & Lifestyle 1:36:03 Undiagnosed Endometriosis, Fertility 1:39:26 Endometriosis: Symptoms, Diagnosis, Painful Periods, Infertility 1:42:30 Male vs Female Health Issues, Undiagnosed Endometriosis 1:47:01 Inflammation, Ectopic Implants, Chronic Pelvic Pain; Adenomyosis 1:50:36 Egg Quality, Endometriosis, Tools: Egg Counts; Pelvic Ultrasound 1:54:29 Sponsor: Function 1:56:13 Pain & Health Testing, Tool: Endometriosis Symptoms, Screening & Tests 2:01:32 Treatment, Surgery, Different Types of Endometriosis 2:05:22 Endometriosis Causes, Inflammation; Incidence, PCOS 2:11:58 Obstetrics & Gynecology Separation, Surgery 2:16:00 Endometriosis Key Takeaways: Symptoms, Treatment & Diagnosis 2:17:04 Treatment, Estrogen & Progesterone, Birth Control, GnRH Antagonists 2:22:39 Endometriosis Stage & Pain, Endometriosis Types 2:23:49 Pregnancy; Postpartum Depression, Menopause; Frustration for Patients 2:29:55 Fibroids, Surgery, Uterine Septum, Tool: Pelvic Ultrasound 2:34:05 Tool: Assessing Your & Partner's Fertility; Autoimmune Conditions 2:37:51 Breast Cancer, Tool: Lifetime Risk Calculator & Breast Imaging; Mastectomy 2:49:47 Endometriosis Tests, Autoimmune Disease; Brain Fog & Menopause; Inositol 2:53:06 Undiagnosed Infertility; PMDD Treatment; Fasting & Low-Carbohydrate Diets 2:57:21 Hair Loss & Perimenopause; Egg Quality; Endometriosis & Menopause 3:00:40 Increase Progesterone; Diet, Hormone & Menopause; Prolong Fertility 3:04:54 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

#288: Most women with PCOS are given the same 3 options: birth control, metformin, or nothing. But when 80% of women with PCOS have insulin resistance, only one of those actually helps address the root cause. In this episode, we break down the difference between inositol, metformin, and birth control for PCOS and discuss what actually works for insulin resistance and symptoms like cravings, fatigue, irregular periods, and stubborn belly weight. You'll learn: - What insulin resistance really is and why it drives PCOS symptoms - Inositol vs Metformin vs Birth Control, and how each one works - How to pair inositol with diet, movement, sleep, and stress tools for better results - What to look for when choosing the right inositol supplement for your journey This episode is for you if: - You've tried birth control or metformin but still feel stuck - You want a safer, research-backed approach to insulin resistance with PCOS - You're curious if inositol could be the missing piece in your routine Download The Cysterhood App, the largest community of PCOS women learning to lose weight & reverse symptoms with daily meals & workouts designed for PCOS! What's Your PCOS Type? - Take the quiz! Metabolism Plus - Our PCOS Supplement Line! Ovasitol: 15% OFF CONNECT WITH US: Website Instagram Tik Tok YouTube Pinterest While Tallene is a Registered Dietitian and Sirak a Personal Trainer, this podcast provides general information about PCOS. It is not meant to serve as fitness, nutrition or medical advice related to your individual needs. If you have questions, please talk to a medical professional. For our full privacy policy, please click on the following link: (bit.ly/PCOSPrivacyPolicy) Links included in this description may be affiliate links. If you purchase a product or service with the links that we provide, we may receive a small commission. There is no additional charge to you! Thank you for supporting our channel so we can continue to provide you with free content each week!

AI is transforming medicine at a speed never seen before. In this episode, you'll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he's a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension. Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today's standards. You'll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life. You'll Learn: • How digital twins will end human drug testing • Why AGI could replace doctors and computer jobs within five years • How AI models immune function, metabolism, and aging • The role of mitochondria and inflammation in longevity • How GLP-1 drugs and metformin extend lifespan • What continuous biological monitoring means for health tracking • How AI is transforming functional medicine and personalized care • Why NAD and energy metabolism are key to human performance They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You'll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan. This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation. This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You'll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, Metabolism, AGI, Clinical trials, Human performance, Aging research, Systems biology, Immunology, Smarter Not Harder Thank you to our sponsors! BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order Resources: • Keep up with Derya's work: https://x.com/derya_?lang=en • Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 — Trailer 01:25 — Intro 02:26 — AI's Role in Extending Lifespan 02:56 — Regulatory Frameworks and Medical Adoption 05:19 — Problems with the Immune System 08:19 — Chronic Fatigue and Long COVID Research 10:32 — Modern Testing and Multi-Omic Analysis 14:07 — Personal Longevity Strategy and Supplements 15:17 — Understanding Exhausted Cells 23:43 — Personalization in Medicine and AI Analysis 31:35 — Longevity Escape Velocity 36:13 — AI Doctors and Prescriptions 39:55 — Data Quality Concerns in AI Training 43:19 — The Future of Wearable Technology 45:50 — Revolutionizing Education with AI 49:04 — The Future of Higher Education 52:03 — Future of Work and AI Agents See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Chrissy: Hi dr Cabral Is it ok to that estrogel and progesterone for menopause if you have lymphoedema ? Or will it make it worse .. kind regards Chrissy                                                                                                                                                    Kay: Hi Dr. Cabral- What are your thoughts on Metformin combined w Naltrexone topiramate and Vit B12 for Tx of PCOS? My 31 y.o. daughter has tried over the last few years to manage her PCOS w traditional Chinese herbs, acupuncture, yoga & pilates which have only given her limited success. Her HbA1c were in the pre-diabetic range. She lives in the NYC area w a demanding job. Now, working w a Functional Med provider, her tests showed high levels of cortisol throughout the day & hormonal imbalances. Weekend hikes & being near nature on occasion have helped her stress levels as shown by her Oura ring data. After about a month of the Rx regimen, she has noticed an improvement in her HbA1c and has hired a personal trainer. For true, sustainable wellness, what do you recommend?                                       Becky: Hi Dr. Cabral! Thank you for ALL that you do and thank you for using your story to help heal others! I am an IHP2 and need advice. I am working with a client, she is in her mid 30s and she has had horrific breath and overall dryness of her entire body since a child. Her dad and siblings have the same issues along with her oldest daughter. She has tried EVERY imaginable product to fix her breath with zero success. She has done the 21 day detox, & is finishing up the CBO Protocol with H.Pylori & will be starting the Finisher. She did a HTMA last year with someone else but nothing alarming. She is hopeless that her breath can't be fixed. What is your suggestion as to what direction we should go next? She does not drink filtered water, is on birth control & an anti depressant. THANKS!!!!            Kayley: I am 24 yrs old 5'2" 123lbs. I have diagnosed Rheumatoid Arthritis that has severely impacted my life. I currently take Methotrexate, Plaquenil, Folic Acid, and Folinic Acid. I am struggling with debilitating fatigue, and my IBS has recently flared up. Is there anything you would suggest doing to improve energy levels?                               Amanda: Does chiropractic treatment benefit children diagnosed with ADHD?     Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3509 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

My guest is Michael Snyder, PhD, professor of genetics at Stanford and an expert in understanding why people respond differently to various foods, supplements, behavioral and prescription interventions. We discuss how to optimize your health and lifespan according to what type of glucose responder you are, which genes you express, your lifestyle and other factors. Dr. Snyder also explains the key ages when you need to be particularly mindful about following certain health practices. We also discuss how people respond in opposite ways to different fiber types. This episode ought to be of interest and use to anyone seeking to understand their unique biological needs and how to go about meeting those needs. Sponsors AGZ by AG1: https://drinkag1.com/huberman Wealthfront*: https://wealthfront.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman *This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27,‬ 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable‭ APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer. Timestamps 00:00 Michael Snyder 03:33 Healthy Glucose Range, Continuous Glucose Monitors CGM, Hemoglobin A1c 09:02 Individual Variability & Food Choice, Glucose Spikes & Sleepiness 12:18 Sponsors: AGZ by AG1 & Wealthfront 15:16 Glucose Spikes, Tools: Post-Meal Brisk Walk; Soleus “Push-Ups”; Exercise Snacks 21:06 Glucose Dysregulation, Diabetes & Sub-Phenotypes, Tool: Larger Morning Meal 28:34 Exercise Timing, Muscle Insulin Resistance 30:49 Diabetes Subtyping, Weight, Glucose Control; Incretins 35:41 GLP-1 Agonists, Diabetes, Tool: Muscle Maintenance & Resistance Training 38:40 Metformin, Berberine, Headaches 41:01 GLP-1 Agonists, Cognition, Longevity, Tool: Habits Support Medication; Cycling 47:41 Subcutaneous vs Visceral Fat, Organ Stress 49:10 Sponsors: David & Eight Sleep 51:58 Meal Timing & Sleep, Tools: Post-Dinner Walk, Routines, Bedtime Consistency 57:16 Microbiome, Immune System & Gut; Diet & Individual Variability 1:02:52 Fiber Types, Cholesterol & Glucose, Polyphenols 1:09:50 Food As Medicine; Fiber, Microbiome & Individual Variability; Probiotics 1:18:48 Sponsor: Function 1:20:35 Profiling Healthy Individuals, Genomes, Wearables 1:26:31 Whole-Body MRIs, Nodules, Healthy Baseline, Early Diagnosis 1:34:07 Sensors, CGM, Sleep, Heart Rate Variability HRV, Tools: Mindset Effects, Increase REM 1:39:30 HRV, Sleep, Exercise, Tool: Long Exhales; Next-Day Excitement & Sleep 1:42:48 Organ Aging, “Ageotypes”; Biological Age vs Chronological Age 1:49:41 Longevity, Health Span, Genetics, Blue Zones 1:52:19 Epigenetics, Viral Infection & Disease 1:58:54 ALS, Heritability; Neuroprotection, Nicotine 2:03:47 Air Quality, Allergies, DEET & Pesticides, Inflammation, Mold; Microplastics 2:15:02 Single-Drop Blood Test & Biomarkers, Wearables, Observational Trials 2:20:33 Acupuncture, Blood Pressure 2:26:40 Immersive Events & Mental Health Benefits 2:34:59 Data, Nutrition & Lifestyle; Siloed Health Care vs Personalized Medicine 2:43:06 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Dominic D'Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.This episode is brought to you by: Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine: https://livemomentous.com/tim (code TIM for up to 35% off)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)Timestamps:[00:00:00] Start.[00:14:43] Why I'm interested in ketogenic strategies for neurodegenerative prevention.[00:16:18] Mary and Steve Newport's ketone-linked temporary cognitive improvements.[00:18:18] A mechanisms overview for Alzheimer's/dementia.[00:21:25] The immune system as longevity's "fifth horseman" — and why metabolic control is key.[00:22:04] How to measure ketones and GKI.[00:23:00] Fasting vs. ketogenic diet.[00:24:18] There's nothing fishy about sardine fasting.[00:28:32] My hiatal hernia discovery and increased cancer risk concerns.[00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk.[00:31:57] Glucose tolerance testing revelations and CGM importance.[00:31:57] Upgrading the metabolic machinery through keto without getting bored.[00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.[00:43:42] Dom's day-to-day diet regimen.[00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.[00:51:30] Supplementing for sleep disruption while fasting.[00:55:41] Why Dom doesn't have misgivings about melatonin.[00:59:15] Shingles prevention through fasting protocols.[01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.[01:03:54] Dom at 50-something: Current meal timing and composition.[01:05:57] Blue zone observations: Greek and Sardinian longevity habits.[01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.[01:15:18] Ketone metabolic therapy for cancer.[01:18:15] The metabolic psychiatry revolution.[01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.[01:28:27] Metformin vs. berberine.[01:31:43] The low-dose neuroprotective potential of GLP-1 drugs.[01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health.[01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.[01:42:05] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.[01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.*Show notes for this episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Huberman Lab Essentials episode, I explore intermittent fasting and time-restricted eating, highlighting the positive benefits for weight loss, metabolism, organ health, circadian rhythms and cellular repair. I explain a practical framework for designing a time-restricted eating window that aligns with your lifestyle, exercise schedule and social schedule. I also cover what breaks a fast, how to support fasting with tools like salt intake and post-meal walks, and the use of fasting-related supplements, including berberine and metformin. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Carbon: https://joincarbon.com/huberman LMNT: https://drinklmnt.com/huberman Joovv: https://joovv.com/huberman Timestamps (00:00) Intermittent Fasting, Time-Restricted Eating (TRE) (00:50) Diet, Weight Loss, Calories & Hormones (05:50) Body's Response to Eating vs Fasting, Fasting Duration (09:04) Sponsor: Carbon (10:50) Time-Restricted Feeding & Metabolic Benefits, Circadian Gene Rhythm (16:19) Optimal Meal Timing, Tool: Extend Sleep-Related Fasts (21:29) Sponsors: AG1 & LMNT (24:02) Eating Window Length, Tools: Adjusting TRE for Building Muscle, Regularity (26:55) Accelerate Transition to Fasting, Glucose Clearing, Tool: After-Meal Walk (28:36) Metformin, Berberine, Continuous Glucose Monitors; Cell Growth vs Repair, mTOR (31:46) Gut Microbiome; Transitioning to Intermittent Fasting & Individualization (34:03) Tool: 8-Hour Feeding Window & Weight Loss (35:25) Sponsor: Joovv (36:40) What Breaks a Fast?, Sugar; Tool: Using Salt to Support Fasting (39:42) Tool: Ideal Feeding Window Guidelines; Exercise & Social Considerations Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices