Podcasts about Aspirin

Most men think ED is just a performance issue. It's not. It's one of the earliest warning signs of cardiovascular decline and it often appears years before chest pain, shortness of breath, or heart attack symptoms.Thank you to our sponsors! -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.-GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what's in your air.Chapters00:00 - The “Legal Blue Pill” Myth & Hidden Danger00:57 - What ED Actually Is (Not the Commercial Version)01:45 - Circulation, Arteries & the Real Root Cause03:27 - The Problem with Relying on ED Pills05:03 - Treat ED as a Cardiovascular Symptom05:55 - Patterns That Reveal Vascular Decline07:10 - The ED–Heart Attack Countdown Window08:14 - How To Fix This Problem10:10 - Microdosing Cialis for Vascular Support10:45 - Aspirin as Another Option11:15 - Lifestyle Drivers of Vascular Damage & Solutions13:15 - Movement, Walking & Circulation Basics13:40 - The Mitochondria–Erection Connection15:00 - Recharging Mitochondria16:02 - Chronic Inflammation: The Silent Culprit17:17 - Smoking, Vaping, Obesity & Diabetes18:30 - How To Reduce InflammationResources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ Facebook: https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Drs Harrington and Gibson's annual review of cardiovascular medicine: ACS guidelines, antiplatelet management, GLP-1s, and ever lower LDL-C with drugs or even gene editing are among the highlights. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington New ACS Guidelines 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes https://doi.org/10.1161/CIR.0000000000001309 ACS Guideline Chair and Vice-Chair Discussion https://www.medscape.com/viewarticle/acs-guidelines-2025-key-points-chair-and-vice-chair-2025a100093l Antiplatelet/Antithrombotic Strategies Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes (NEO-MINDSET) https://www.nejm.org/doi/full/10.1056/NEJMoa2507980 Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC) https://www.nejm.org/doi/full/10.1056/NEJMoa2507532 Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making : ENGAGE AF-TIMI 48 Trial Analysis https://doi.org/10.1016/j.jacadv.2025.102504 Factor XI Inhibitors Bristol Myers, J&J Stop Blood Clotting Drug Trial After Interim Review https://www.medscape.com/s/viewarticle/bristol-myers-j-j-stop-blood-clotting-drug-trial-after-2025a1000vqu Bayer's Asundexian Met Primary Efficacy and Safety Endpoints in Landmark Phase III OCEANIC-STROKE Study in Secondary Stroke Prevention https://www.bayer.com/en/us/news-stories/oceanic-stroke OAC-Naive Subgroup From OCEANIC-AF Published https://www.medscape.com/viewarticle/novel-blood-thinner-shows-promise-atrial-fibrillation-2025a10008lz GLP-1 and Myotrophic Drugs Lilly's Next-gen Drug Shows Greater Weight Loss Than Zepbound in Late-stage Trial (TRIUMPH-4) https://www.medscape.com/s/viewarticle/lillys-next-gen-drug-tops-zepbound-weight-loss-late-stage-2025a1000ys1 Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf CRISPR and Lipid Lowering Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease https://www.nejm.org/doi/full/10.1056/NEJMoa2504747 Gene Therapy Shows Lipid Improvement but Raises Flags https://www.medscape.com/viewarticle/gene-therapy-shows-lipid-improvement-raises-flags-2025a1000uzw Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 https://www.nejm.org/doi/full/10.1056/NEJMoa2511778 Evolocumab in Patients without a Previous Myocardial Infarction or Stroke (VESALIUS-CV) https://www.nejm.org/doi/pdf/10.1056/NEJMoa2514428 Prehospital GLP IIb/IIIa Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction (CELEBRATE) https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-465 Overview: Many patients with coronary artery disease take aspirin, but how should clinicians navigate management when an anticoagulant is also needed? In this episode, we review indications for therapy, explore evidence on dual use, and discuss how to counsel patients on balancing cardiovascular benefits with the risks of combination therapy. Episode resource links: Lemesle G, Didier R, Steg PG, et al. Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation. N Engl J Med. Published online August 31, 2025. https://www.nejm.org/doi/full/10.1056/NEJMoa2507532 Guest: Alan M. Ehrlich, MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-465 Overview: Many patients with coronary artery disease take aspirin, but how should clinicians navigate management when an anticoagulant is also needed? In this episode, we review indications for therapy, explore evidence on dual use, and discuss how to counsel patients on balancing cardiovascular benefits with the risks of combination therapy. Episode resource links: Lemesle G, Didier R, Steg PG, et al. Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation. N Engl J Med. Published online August 31, 2025. https://www.nejm.org/doi/full/10.1056/NEJMoa2507532 Guest: Alan M. Ehrlich, MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction (TARGET-FIRST)

Nutritionist Leyla Muedin details key aspects of supplement use and addresses frequently asked questions. Topics include the importance of targeted supplementation, the rationale behind personalized dosages, best practices for starting new supplements, and managing common issues like nausea and bright yellow urine. Leyla also explains why some supplements may cause gastrointestinal discomfort and provides guidance on how to adjust dosages for optimal results. Emphasis is placed on the benefits of pharmaceutical-grade supplements available on Fullscript and the necessity of regular blood tests to fine-tune supplementation.

In dieser Folge spreche ich über ein Thema, das unglaublich wichtig ist, aber viel zu selten erklärt wird:Wechselwirkungen zwischen Medikamenten und Supplementen.Viele Frauen nehmen Medikamente und gleichzeitig Vitamine, Kräuter, Omega-3, oder pflanzliche Mittel wie Ashwagandha oder Johanniskraut. Doch einige dieser Kombinationen können die Wirkung deiner Medikamente verstärken, blockieren oder sogar gefährlich verändern.Du erfährst in dieser Episode: • Warum Piperin und Grapefruit deine Entgiftungsenzyme blockieren • Welche Nahrungsergänzungen Aspirin gefährlich verstärken • Warum Migräne-Mittel nicht mit 5-HTP oder Johanniskraut zusammenpassen • Wieso Magnesium den Effekt von Blutdrucksenkern verdoppeln kann • Welche Kombinationen dein Nervensystem zu stark dämpfen • Warum Frauen hormonell besonders empfindlich auf Wechselwirkungen reagierenDiese Folge ist für dich, wenn du Medikamente nimmst, PMS-, Zyklus- oder Stresssymptome hast oder einfach Klarheit darüber möchtest, wie Supplemente wirklich wirken. Dein Körper verdient Sicherheit, keine Zufallskombination.Ich bin Laura Kohler, Neurobiologin & Health Coach, und ich helfe dir, deinen Körper so zu verstehen, dass du Entscheidungen mit Klarheit treffen kannst.✨Unverbindliche Sprechstunde

Send us a textWelcome back Rounds Table Listeners! In our year-end episode, Drs. Mike and John Fralick discuss five important research studies published in 2025:Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO) (0:00 – 4:20)Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity (SUMMIT) (4:21 – 9:30)Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC) (9:31 – 15:03)Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial (FRESH-UP) (15:04 – 18:09)Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (ESSENCE) (18:10 – 23:49)The Good Stuff (23:50 – 25:27):Toronto Star Santa Claus Fund, Calgary Food Bank, The War Amps Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

Estimated reading time: 11 Minuten Im B2B-Vertrieb verkaufst du nicht "Features". Du verkaufst Klarheit, und du verkaufst Entscheidungssicherheit. Genau darum geht es hier: Bedarfsermittlung im B2B – nicht irgendwann, sondern planbar, sauber und wiederholbar. Statt nur zu hören, was der Kunde sagt, willst du verstehen, was wirklich dahintersteckt, damit du nicht am Symptom hängen bleibst. Gleichzeitig brauchst du den Blick fürs Buying Center, weil sonst der echte Entscheider unsichtbar bleibt. Und damit sind wir beim Kern: Entscheider identifizieren ist nicht „nice to have", sondern Pflicht, wenn du nicht in Endlosschleifen verkaufen willst. In meinem Gespräch mit Stephan Heinrich haben wir das auseinandergebaut und wieder zusammengesetzt. Du bekommst daraus einen Praxis-Guide, den du direkt in Discovery Calls, Qualifizierung und Angebot übernehmen kannst, sodass du weniger "Wir melden uns" hörst und mehr echte Entscheidungen auslöst. Und ja: Wir zeigen dir, wie du den Entscheider identifizieren-Job systematisch erledigst – weil gute Bedarfsermittlung genau dort gewinnt. Kundenergründung 3.0: Was sich im B2B für die Bedarfsermittlung geändert hat Viele Verkäufer machen heute denselben Fehler wie vor 15 Jahren – nur mit besserer Kamera: Sie springen zu früh in die Lösung, und oft sogar in Minute 3. Sobald PowerPoint läuft, verlierst du aber leicht die Gesprächsführung, weil der Kunde dann bewertet, während du lieferst. Genau deshalb musst du zuerst Problem und Prozess klären, und du musst frühzeitig den Entscheider identifizieren, bevor du in die Demo rutschst. Kundenergründung 3.0 akzeptiert drei harte Realitäten, und genau deshalb funktioniert sie so gut: Mehr Stakeholder: Du verkaufst selten an eine Person, sondern ans Buying Center. Mehr Risiko: Der Kunde entscheidet nicht nur für, sondern auch gegen den Status quo, und das fühlt sich intern riskant an. Mehr "No Decision": Viele Deals sterben nicht am Wettbewerb, sondern an Aufschieberitis, Unsicherheit oder fehlender Priorität. Die PowerPoint-Falle: Warum "früh präsentieren" deine Bedarfsermittlung zerstört Sobald du präsentierst, passiert Folgendes: Der Kunde lehnt sich zurück, du arbeitest, und er bewertet. Am Ende kommt dann oft der Satz: "Schicken Sie mal ein Angebot." Das klingt wie ein Kaufsignal, ist aber häufig nur ein höfliches "Ich will jetzt aus dem Call raus." Die Alternative ist simpel, aber nicht leicht: Du bleibst im Dialog, und du gräbst tiefer, damit am Ende wirklich Klarheit entsteht. Außerdem erkennst du dadurch viel früher, ob der Deal echt ist oder nur "mal schauen". Und du kannst nebenbei direkt den Entscheider identifizieren, statt später hinterherzulaufen. Bedarfsermittlung heißt heute: Entscheidung ermöglichen Der moderne Verkäufer ist nicht nur Problemlöser, sondern auch Entscheidungs-Architekt. Du hilfst dem Kunden, intern zu erklären, warum eine Veränderung nötig ist, und warum sie jetzt passieren muss. Gleichzeitig sorgst du dafür, dass die richtigen Menschen beteiligt sind, weil du sonst zwar diskutierst, aber nie abschließt – daher: Entscheider identifizieren. Warum wir etwas ändern müssen Warum wir es jetzt ändern müssen Warum wir es mit dieser Lösung ändern können Und wer dazu "Ja" sagen muss Das ist Kundenergründung 3.0. Und das ist Bedarfsermittlung, die wirklich Umsatz macht. Das wahre Problem finden: Vom Symptom zur Diagnose (Basis jeder Bedarfsermittlung) Ich nutze dafür gern ein Bild: Arzt vs. Apotheke. Der Kunde kommt rein und sagt: "Ich hab Kopfschmerzen." Wenn du jetzt direkt "Aspirin" verkaufst, bist du Apotheke, aber nicht Berater. Fragst du dagegen "Seit wann? Wo genau? Was war vorher, und was haben Sie schon probiert?", dann wirst du zum Arzt – und erst eine saubere Diagnose macht deine Bedarfsermittlung wertvoll. Für eine stabile Bedarfsermittlung brauchst du drei Ebenen, und jede Ebene baut auf der vorherigen auf: Ebene 1: Das Symptom (was der Kunde sagt) "Unsere Leads sind schlecht." "Unser Forecast wackelt." "Wir brauchen ein neues Tool." Ebene 2: Die Ursache (warum es passiert) Fehlt eine saubere Qualifizierung, oder fehlt ein gemeinsames Verständnis? Ist der Entscheidungsprozess unklar, und deshalb bleibt alles hängen? Gibt es keinen Champion, obwohl das Thema wichtig wäre? Ebene 3: Der Impact (was es kostet) Jetzt wird's spannend: Sobald du den Impact sauber machst, verändert sich das Gespräch, weil aus "nice to have" ein "müssen wir lösen" wird. Damit wird deine Bedarfsermittlung automatisch schärfer, und du hast außerdem einen klaren Aufhänger, um den Entscheider identifizieren-Part sauber anzustoßen. Fragen, die dich sofort tiefer bringen "Was passiert, wenn Sie das nicht lösen?" "Woran merken Sie das konkret – in Zahlen, Zeit oder Risiko?" "Was haben Sie bisher probiert, und warum hat's nicht gereicht?" "Wer merkt den Schaden am stärksten?" (Denn dort sitzt oft der Sponsor – und manchmal auch der echte Entscheider.) Merksatz: Bedarfsermittlung entsteht nicht durch "mehr reden", sondern durch Zusammenhänge, die der Kunde intern weitergeben kann. Schmerz in Euro: So wird Bedarfsermittlung messbar und wirksam Viele Verkäufer sind nett, und das ist grundsätzlich gut. Ohne Dringlichkeit gewinnt jedoch immer der Status quo, weshalb du in Richtung Entscheidung einen harten Schritt brauchst: Quantifizierung. Du machst keinen Druck, sondern du schaffst Klarheit, und dadurch wird auch deutlich, wer intern wirklich entscheiden muss – also: Entscheider identifizieren. Die Kosten der Nicht-Entscheidung Hilf dem Kunden nicht nur beim "Warum kaufen?", sondern auch beim "Warum NICHT warten?". Das gelingt, wenn du den Schaden greifbar machst und gleichzeitig die Logik sauber hältst: "Was kostet Sie das Problem pro Monat?" "Wie viele Stunden gehen dabei verloren, und wo genau?" "Welches Risiko tragen Sie, wenn das so bleibt?" Das Ziel ist nicht, den Kunden zu grillen, sondern ihm eine Rechnung zu geben, die er intern verwenden kann. Gute Bedarfsermittlung fühlt sich für den Kunden an wie: "Endlich versteht mich jemand." Critical Event: Warum jetzt? Wenn du Deals beschleunigen willst, brauchst du ein Ereignis, ein Datum oder einen Auslöser. Ohne dieses "Warum jetzt?" wird alles vertagt, obwohl das Problem real ist. Und wenn vertagt wird, verschwimmt fast immer auch, wer zuständig ist – deshalb: Entscheider identifizieren und Verantwortlichkeiten festzurren. "Was muss bis wann stehen – und warum genau dann?" "Was passiert, wenn Sie das Datum reißen?" "Welche internen Meilensteine hängen daran, und wer verantwortet sie?" Klärst du das nicht, bekommst du "Wir melden uns", und dann meldet sich: niemand. Preis ohne Drama: Obergrenze & Preis-Fragmentierung Viele Verkäufer trauen sich nicht über Geld zu reden, und dadurch entstehen falsche Erwartungen. Zwei saubere Wege, die Entscheidung zu erleichtern, sind: Obergrenze: Du nennst eine klare Decke (mit Pause), sodass der Kunde sofort einordnet. Beispiel: "Wenn Sie befürchtet haben, dass Sie 35.000 Euro investieren müssen: da liegen wir auf jeden Fall drunter." Fragmentierung: Du brichst den Preis auf eine verdauliche Einheit runter (pro Verkäufer/Monat oder pro Standort/Woche), damit es entscheidbar wird. Das ist keine Manipulation, sondern es reduziert Unsicherheit, und Unsicherheit ist der natürliche Feind jeder guten Bedarfsermittlung. Den echten Entscheider finden: Buying Center, Economic Buyer & Bedarfsermittlung Jetzt wird's politisch, aber im besten Sinne: Unternehmensrealität. In komplexen Deals gibt es selten "den Entscheider", sondern mehrere Rollen, und du musst sie trennen, damit deine Bedarfsermittlung nicht zur Blackbox wird. Kurz gesagt: Entscheider identifizieren ist dein Sicherheitsgurt im komplexen Vertrieb. Der Mythos "Mein Chef macht, was ich sage" Ich höre ständig: "Ich bin nah dran am Chef." Das ist gut, aber Nähe ist kein Unterschriftrecht. Wenn du nur mit Beeinflussern sprichst, bekommst du schöne Gespräche, jedoch keine Entscheidung. So fragst du den Entscheidungsprozess ab (ohne peinlich zu wirken) Diese Formulierung funktioniert fast immer, weil sie den Kunden schützt und dich gleichzeitig führt: "Damit ich Ihnen nichts Falsches baue: Wie wird so eine Entscheidung bei Ihnen typischerweise getroffen?" Danach gehst du strukturiert weiter, und zwar mit einer Decision Map, die intern tragfähig ist. Ziel: Nicht raten, sondern sauber Entscheider identifizieren: Decision Criteria: "Woran machen Sie die Auswahl fest, und was ist 'must have'?" Decision Process: "Welche Schritte kommen nach diesem Gespräch, und wann?" People: "Wer muss am Ende zustimmen – fachlich, finanziell und operativ?" Risiko: "Wer trägt den Ärger, falls es schiefgeht?" Der Entscheider-Test: Der Konditionalabschluss Jetzt kommt ein Hebel, der vielen Bauchschmerzen macht, aber brutal effektiv ist: der Konditionalabschluss. Das ist eine geschlossene Frage, weil du Klarheit willst und nicht Hoffnungen sammelst. "Wenn ich Ihnen das so zuschicke: sind wir dann auf dem Weg zur Entscheidung?" Warum ist das so stark? Weil du echte Informationen bekommst. Entweder es gibt ein Ja (mit Bedingungen), oder es gibt ein Nein (mit Gründen), und beides bringt dich weiter. Und vor allem zeigt es dir, ob du wirklich den Entscheider identifizieren-Schritt schon erledigt hast. Das Angebot als Entscheidungsdokument: "Heiratsantrag" statt PDF-Friedhof Ein Angebot ist kein Preisblatt, und es ist auch kein Roman. Es ist ein Entscheidungsdokument, das intern weitergeleitet werden kann, ohne dass du daneben sitzt. Damit das klappt, musst du vorher Problem, Impact und Rollen geklärt haben – inklusive "Entscheider identifizieren". Was in ein gutes B2B-Angebot gehört (und was nicht) Ich mag Angebote, die klar, kurz und intern verwertbar sind. Drei Bausteine reichen, wenn sie sauber sind: Ausgangslage: Was ist heute? (Symptom + Ursache, wie ihr es verstanden habt) Zielbild: Was soll danach besser sein? (Kennzahlen, Outcome, Nutzen) Hindernisse: Warum ging's bisher nicht? (Risiken, interne Blocker, fehlende Ressourcen) Erst dann kommen Lösung, Vorgehen, Investment und nächste Schritte. So wird aus Interesse eher eine Entscheidung, statt ein "Wir prüfen mal". Und ja: Eine saubere Bedarfsermittlung macht genau diesen Unterschied. Die stärkste Angebotsfrage überhaupt Wenn du nur eine Frage vor dem Angebot stellst, dann diese, weil sie alles fokussiert: "Was muss im Angebot stehen, damit Sie entscheiden können?" Damit baust du nicht dein Lieblingsangebot, sondern das Angebot, das intern durchkommt. KI-Boost: So machst du Bedarfsermittlung schneller und sauberer Fast alle Calls sind online, und das ist eine Chance, wenn du sie sauber nutzt. Mit Einwilligung kannst du Transkripte verwenden, sodass du besser zuhörst und trotzdem alles sauber dokumentierst. Gerade bei Stakeholdern hilft das, weil du Aussagen besser zuordnen kannst und schneller Entscheider identifizieren kannst. Transkript aktiv einschalten (und dadurch besser zuhören) "Ich würde gern das Transkript einschalten, damit ich Ihnen noch besser zuhören kann. Ist das für Sie okay?" Wichtig: Hol dir immer eine klare Zustimmung und beachte eure Regeln, weil Vertrauen die Basis ist. Wenn der Kunde nein sagt, ist das okay, und dann schreibst du klassisch mit. Vom Gespräch direkt ins Angebot (ohne Copy-Paste-Hölle) Mit einem sauberen Protokoll baust du in Minuten: Zusammenfassung in 7 Zeilen (Problem, Ursache, Impact, Ziel, Timeline) Decision Map (wer, wann, wie, womit) Risiken & Einwände (und wie du sie im Angebot vorweg nimmst) Das spart Zeit, und es reduziert Missverständnisse, sodass deine Bedarfsermittlung nicht nur schneller wird, sondern auch stabiler. Sales-Training als "Flugsimulator": schneller besser werden Ich liebe das Bild: Im Flugsimulator darfst du Fehler machen, während du im echten Flugzeug besser keine machst. Genau so ist Vertrieb, weshalb du Discovery und Decision Map trainieren solltest, bevor du Einwände übst. Und im Training kannst du gezielt üben, wie du den Entscheider identifizieren-Teil sauber, ruhig und ohne Druck formulierst. Quick Takeaways: Die wichtigsten Punkte zur Bedarfsermittlung Bedarfsermittlung gewinnt, wenn Problem, Impact und Entscheidungsweg glasklar sind. Geh vom Symptom zur Ursache, und mach danach den Impact in Euro, Zeit oder Risiko sichtbar. Kläre ein Critical Event, sonst gewinnt der Status quo, obwohl alle nicken. Baue eine Decision Map: Kriterien, Prozess, Rollen und Risiko-Träger. Entscheider identifizieren ist kein "später", sondern Teil der Bedarfsermittlung. Nutze den Konditionalabschluss, damit du Klarheit bekommst und nicht rätst. Mach dein Angebot zum Entscheidungsdokument, damit es intern funktioniert. Anleitung: Bedarfsermittlung im B2B in 9 Schritten (Discovery-Checkliste) So führst du Gespräche, die Problem, Impact und Entscheider sauber klären, damit eine Entscheidung möglich wird – und zwar ohne Präsentations-Falle und ohne endlose Follow-ups. Das ist Bedarfsermittlung, die im Alltag funktioniert. Eröffnung mit Erwartungsmanagement Sag kurz, wie ihr vorgeht: erst Kontext und Ziele, dann Entscheidungsweg und nächste Schritte – Demo später (wenn nötig). Symptom verstehen Lass den Kunden erzählen, und frag nach Beispielen, bevor du Lösungen ansprichst. Ursache finden Frag nach dem "Warum", und klär gleichzeitig, was bisher versucht wurde. Impact quantifizieren Euro, Zeit oder Risiko, damit Dringlichkeit entsteht und Entscheidungen logisch werden. Decision Map aufbauen Kriterien, Prozess und Rollen klären, damit du nicht rätst, sondern den Entscheider identifizieren kannst. Critical Event klären Bis wann muss was stehen, und was passiert, wenn nicht? Echten Entscheider identifizieren Frag nach Budget- und Freigaberechten, und klär, wer final "Ja" sagt. Ziel: Entscheider identifizieren statt hoffen. Entscheider-Test setzen Nutze eine klare Frage, damit du weißt, ob ihr wirklich vorankommt. Nächste Schritte verbindlich machen Termine, Verantwortliche und Deliverables festlegen, damit es nicht im Sande verläuft. FAQ: Häufige Fragen zur Bedarfsermittlung im B2B Was bedeutet Bedarfsermittlung im B2B? Bedarfsermittlung bedeutet, dass du Symptom, Ursache und Impact klärst und zusätzlich Entscheidungsweg und Rollen im Buying Center sichtbar machst, damit der Kunde intern entscheiden kann. Warum ist "Entscheider identifizieren" so wichtig? Weil viele Deals nicht am Produkt scheitern, sondern daran, dass niemand final verantwortlich ist. Wenn du den Entscheider identifizieren kannst, werden nächste Schritte klarer, und Entscheidungen fallen schneller. Wie frage ich den Entscheidungsprozess ab, ohne unangenehm zu wirken? Nutze eine Schutz-Formulierung wie: "Damit ich Ihnen nichts Falsches baue: Wie wird so eine Entscheidung bei Ihnen typischerweise getroffen?" Das wirkt professionell, weil es Klarheit schafft. Welche Fragen machen die Bedarfsermittlung besser? Fragen zu Impact und Dringlichkeit ("Was kostet das pro Monat?", "Warum jetzt?") und Fragen zur Decision Map ("Wer muss zustimmen?", "Woran wird entschieden?"). Wie nutze ich KI, ohne dass es komisch wirkt? Hol dir eine klare Zustimmung für Transkript/Mitschrift, erkläre den Nutzen ("damit ich besser zuhören kann"), und halte dich an eure Datenschutzregeln. Dann wird es normal und hilfreich.

Low-dose aspirin, often called baby aspirin, is one of the most commonly recommended medications in pregnancy today. But despite how frequently it's prescribed, many patients still ask the same questions: Why do I need it? Is it safe? When should I start or stop? And who actually benefits? In this episode, we take a clear, evidence-based look at baby aspirin in pregnancy—cutting through myths, confusion, and mixed messaging. In this episode, we cover: What "baby aspirin" actually is (dose, formulation, and how it works) Why it's recommended in pregnancy, especially for preventing preeclampsia Who should take it—including high-risk and moderate-risk patients When to start and when to stop (timing matters) What the research says about safety for both parent and baby Common concerns and misconceptions, including bleeding risk What to do if you're unsure or were told conflicting advice Why baby aspirin matters: Preeclampsia remains one of the leading causes of pregnancy complications worldwide. Decades of high-quality research now show that low-dose aspirin, started early in pregnancy for the right patients, can significantly reduce risk—with an excellent safety profile. For many patients, this simple intervention can make a meaningful difference in pregnancy outcomes. Who this episode is for: Pregnant patients wondering "Do I really need this?" Anyone with a history of preeclampsia, hypertension, infertility, IVF, or pregnancy complications Clinicians counseling patients on aspirin use Anyone navigating pregnancy advice that feels unclear or contradictory The takeaway: Baby aspirin isn't about doing more—it's about doing the right thing at the right time, guided by evidence and individualized care. If you've been prescribed baby aspirin—or think you might benefit—this episode will help you understand why it's recommended and how to take it with confidence.   Got something you want to share or ask? Keep it coming.  We love hearing from you. Email us or send a voice memo, and you might just hear it on the next episode. Don't forget to like, comment, and subscribe—your questions could be featured in our next episode! For additional resources and information, be sure to visit our website at Maternal Resources: https://www.maternalresources.org/. You can also connect with us on our social channels to stay up-to-date with the latest news, episodes, and community engagement: YouTube: Dive deeper into pregnancy tips and stories atyoutube.com/maternalresources . Instagram: Follow us for daily inspiration and updates at @maternalresources . Facebook: Join our community at facebook.com/IntegrativeOB Tiktok: NatureBack Doc on TikTok Grab Our Book! Check out The NatureBack Method for Birth—your guide to a empowered pregnancy and delivery. Shop now at naturebackbook.myshopify.com .  

Join Kate, Gary and Mark (Henry has the day off) as we discuss 3 useful new studies: colorectal cancer screening reminders, aspirin or clopidogrel for secondary prevention of CV events, and lipid lowering drugs and dementia risk

Alannah Connealy is a health entrepreneur and author redefining how the world understands wellness. She is the founder of Raena Health, a company dedicated to making hormone support simple, safe, and accessible. Alannah also co-wrote Celluverse, a groundbreaking book that explores cancer through the lens of cellular health and energy. Alannah helps unpack Dr. Ray Peat's bioenergetic approach. Learn why sugar powers cells, meat fuels metabolism, and stress (not cholesterol) harms the heart. Discover PUFA dangers and easy hacks like gelatin gummies and fruit-milk combos to exit "hibernation mode." From the Randle Cycle to cancer as stress response, get practical steps for energy, hormones, and family meals. Reclaim effortless vitality. Some Topics Covered: Keto burnout → pro-metabolic awakening Sugar as cellular fuel, not fat-maker Meat + gelatin: thyroid & anti-inflammatory Randle Cycle, PUFAs, and diabetes traps Aspirin for thyroid, inflammation, energy Cholesterol as protector, not villain Cancer as stress defense, not sugar crime Sponsored By: → CURED | Stack my 20% off code: CLAUDIA on the 10% off Tranquility Bundle! Visit curednutrition.com/claudia and use code CLAUDIA at checkout. → JASPR | Get $400 off for their Black Friday Sale. Just go to jaspr.co/claudia and use my code CLAUDIA → PIQUE | Wake up rested and stay hydrated all day. Get 20% off for life, a complimentary gift, and explore Pique's clean, pure-ingredient products at Piquelife.com/healingthesource. Resources: Check out Raena (discount code: HEALINGTHESOURCE10) for natural hormone support + testing Listen to Alannah's podcast, Celluverse (with Dr. Erin Leigh Connealy and Jess Donovan) Follow Alannah and Raena on Instagram Follow the host, Claudia, on Instagram, check out HealingTheSource.co & Elham's Liquid Gold 100% Organic Castor Oil, and enjoy her deep-dives on Substack

Join us as we review recent articles and news featured in The DIGEST #70, including PSA screening, acetaminophen and autism, COVID19 vaccines and cancer, and aspirin and anticoagulation in coronary artery disease. Fill your brain hole with a delicious stack of hotcakes! Featuring Drs. Paul Williams (@PaulNWilliamz), Nora Taranto (@norataranto), Rahul Ganatra (@rbganatra), Laura Glick (@lauraglick) and Matt Watto (@doctorwatto). Claim free CME for this episode at curbsiders.vcuhealth.org! Episodes | Subscribe | Spotify | Swag! |Mailing List | Contact | CME! Credits Written and Hosted by: Nora Taranto MD; Rahul Ganatra MD MPH, Laura Glick MD, Paul Williams, MD, FACP, Adam Cifu MD, Matthew Watto MD, FACP Cover Art: Rahul Ganatra, MD MPH Reviewers: Rahul Ganatra MD MPH; Paul Williams, MD, FACP, Matthew Watto MD, FACP; Sai S Achi MD, MBA, FACP Technical Production: Pod Paste Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Show Segments Intro, disclaimer Prostate Cancer Screening Acetaminophen and Autism COVID19 vaccines and cancer risk Aspirin and anticoagulation in coronary artery disease Outro Sponsor: Aura Frames For a limited time, save on the perfect gift by visiting AuraFrames.com to get $35 off Aura's best-selling Carver Mat frames by using promo code CURB at checkout. Sponsor: DoxGPT by Doximity Visit doxgpt.com  and see how it can simplify your clinical workflow, from patient care to paperwork.  Sponsor: Continuing Education Company Use promo code Curb30 to get 30% off all online courses and webcasts—just for Curbsiders Listeners. Visit CMEmeeting.org/curbsiders to learn more. Sponsor: Freed Use code: CURB50 to get $50 off your first month when you subscribe!

1872 gelingt es dem Chemiker Wilhelm Haarmann erstmals Vanillin aus Rindensaft von Bäumen herzustellen. Das macht Vanillin zum ersten synthetischen Duftstoff der Welt und seine Herstellung läutete gleichzeitig den Beginn der modernen Duft- und Aromastoffindustrie ein. Wir sprechen in der Folge über Vanille, Vanillin und warum der Vanillerostbraten nach Knoblauch schmeckt. //Erwähnte Folgen * GAG263: Lavoisier und die Entdeckung des Sauerstoffs – https://gadg.fm/263 * GAG444: Die Erfindung von Heroin und Aspirin – https://gadg.fm/444 * GAG284: "There is death in the pot" - Friedrich Accum und die Lebensmittelfälscher – https://gadg.fm/284 * GAG279: Muskat und Manhattan – https://gadg.fm/279 * GAG527: Botanik, Baret und Bougainville – https://gadg.fm/527 * GAG483: Bounty, Brotfrucht und die Rum-Rebellion – https://gadg.fm/483 // Literatur * Björn Bernhard Kuhse, Wilhelm Haarmann auf den Spuren der Vanille: Forscher, Unternehmer und Pionier der Riechstoffe, 2012. * Klaus Stanzl, Die Geburtsstätten der Riechstoffindustrie. Wie die organische Chemie eine Industrie erblühen lässt, 2024. //Aus unserer Werbung Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte: https://linktr.ee/GeschichtenausderGeschichte //Geschichten aus der Geschichte jetzt auch als Brettspiel! Werkelt mit uns am Flickerlteppich! Gibt es dort, wo es auch Becher, T-Shirts oder Hoodies zu kaufen gibt: https://geschichte.shop // Wir sind jetzt auch bei CampfireFM! Wer direkt in Folgen kommentieren will, Zusatzmaterial und Blicke hinter die Kulissen sehen will: einfach die App installieren und unserer Community beitreten: https://www.joincampfire.fm/podcasts/22 //Wir haben auch ein Buch geschrieben: Wer es erwerben will, es ist überall im Handel, aber auch direkt über den Verlag zu erwerben: https://www.piper.de/buecher/geschichten-aus-der-geschichte-isbn-978-3-492-06363-0 Wer unsere Folgen lieber ohne Werbung anhören will, kann das über eine kleine Unterstützung auf Steady oder ein Abo des GeschichteFM-Plus Kanals auf Apple Podcasts tun. Wir freuen uns, wenn ihr den Podcast bei Apple Podcasts oder wo auch immer dies möglich ist rezensiert oder bewertet. Wir freuen uns auch immer, wenn ihr euren Freundinnen und Freunden, Kolleginnen und Kollegen oder sogar Nachbarinnen und Nachbarn von uns erzählt! Du möchtest Werbung in diesem Podcast schalten? Dann erfahre hier mehr über die Werbemöglichkeiten bei Seven.One Audio: https://www.seven.one/portfolio/sevenone-audio

“Study” that's not even a study spreads panic about dubious melatonin-heart failure link; Should you ignore dr's advice to take powerful acid-blocking drugs? Novel implantable electrical pacemakers may bring relief to sufferers of severe constipation; Benefits of cocoa flavanols for heart, brain, athletic performance. Give the gift of healthy chocolate! Go to FlavaNaturals.com and use coupon code HOFFMAN20 for 20% off site-wide. Plus get free shipping on all orders over $30. 

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Preeclampsia affects around 1 in 10 pregnancies, and increasingly we are learning new ways to lower risks. Here's how.In this episode, we are joined by OBGYN and maternal health leader Dr. Amanda P. Williams to talk about what every parent and perinatal professional should know about preeclampsia prevention, warning signs and treatment.Yes, this episode is all about safer pregnancies and healthier babies.You'll learn who's at higher risk, why low-dose aspirin and a home blood pressure cuff can be lifesaving, the postpartum warning signs that should never be ignored, and how doulas, partners, and families can advocate when it matters most - we even include scripts so you will know exactly what to say.Enjoy!Full show notes fourthtrimesterpodcact.comConnect with Dr Amanda P Williams LinkedIn | Instagram | Twitter | Stanford MedicinePreeclampsia Prevention Guides Guide for Parents from March of Dimes | Guide for Clinical Teams from March of Dimes | Low-dose Aspirin to Prevent Preeclampsia & Related Preterm Birth Initiative by CMQCCEssential at-home tools for pregnancy & postpartum Blood Pressure Cuff | AWHONN Post-Birth Warning Signs one-pager to hang on the fridgeWebinar for Health Professionals on Dec 4th 2025 Understanding Preeclampsia Risk and Low-Dose Aspirin – A Global and US PerspectiveLearn more California Maternal Quality Care Collaborative (CMQCC) | The State of Postpartum Maternal Health with Dr Amanda P Williams | Data-Driven Parenting With Dr Amanda P WilliamsOur favorite Fourth Trimester Books The First Forty Days: The Essential Art of Nourishing the New Mother | Becoming the Parent You Want to Be: A Sourcebook of Strategies for the First Five Years | Growing Together: Doula Wisdom & Holistic Practices for Pregnancy, Birth & Early Motherhood |

Ready for your personalized care plan?: Call us Now: 859-721-1414 or visit https://prevmedhealth.com/ Get My 7- Step Heart Attack Prevention Protocol free ebook here: https://45413573.hs-sites.com/ebook

On today's Good Day Health Show - ON DEMAND…Host Doug Stephan and Dr. Ken Kronhaus of Lake Cardiology (352-735-1400) cover a number of topics affecting our health. First up, Doug and Dr. Ken discuss the biggest news stories in the medical world, starting with the cardio-protection that's coming from some of the GLP-1 drugs, an investigative study into how GLP-1 drugs my affect people's risk for developing cancer, how many of these studies are funded by government grants that seem to be in jeopardy vs what is funded by drug companies.Moving on, research shows highlights that the duration of walking matters, with a daily 60-minute walk contributes to longevity and a healthier heart. Another study brings the conversation to low-dose aspirin (AKA baby aspirin) and how it helps those with Type II diabetes. Once upon a time, baby aspirin was given to nearly everyone to prevent he first heart attack, but now the pendulum has swung to far the other way with people who could benefit from it not having the conversations with their doctors about whether or not it's beneficial.Next, there is a new three-pronged blood test that can predict heart attack risk, a surprising find that melatonin to help with sleep may be putting themselves at risk for future heart problems, and how AI can help doctors detect sepsis.Lastly, Doug and Dr. Ken address listener questions, including the benefits of listening to music for those above the age of 70, is there such a thing as too much protein and what are the side effects, and the best multivitamins to add to your health plan.  Website: GoodDayHealthrShow.com Social Media: @GoodDayNetworks

Review of aspirin's mechanism of action, indications, contraindications, and administration for patients with acute coronary syndrome (ACS) or stroke.Aspirin's mechanism of action & benefits for Acute Coronary Syndrome (ACS) patients.Contraindications and considerations for aspirin's use.The dose and route of administration of aspirin for ACS patients.The use of aspirin in the ACLS Stroke algorithm.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Faking It! A new trend is the unfortunate and fraudulent use of "Service Dog" credentials for owners wanting to bring their dogs into restaurants, airlines, and hotels. Pawtopia's Colleen Demling explains the problem and why the disabled suffer. Listen Now Aspirin and Pets Did you know that Aspirin can be toxic to your pet? Dr. Debbie dispels the myths about pain relief for your pet. Listen Now Josh Duhamel Guests Besides a flourishing acting career, Josh Duhamel spends a lot of time speaking for the animals. He has a web series and he's back to talk about it...and to flirt with the ladies. Listen Now A Shot To The Tail Don't be surprised if the next time your cat gets an injection, it's in the tail. Recent concerns have come up over treating rare but potentially deadly injection site sarcomas. Some vets then shifted the site to the hind legs, since an amputation, if necessary, would be easier and more successful. Listen Now Pet ONLY Apartments Octogenarian and Landlord Judy Guth only allows tenants with pets in her apartment complex. Is this discrimination? Judy doesn't care. And if one of her tenants loses their pet, she'll even take them out to dinner and then to the shelter to find another roommate. Listen Now Pet Spending At All Time High The American Pet Products Association reports we're shelling out nearly 60-Billion+ bucks a year on our animals. Research shows empty-nesters are now spending more on their four-legged children. Listen Now Read more about this week's show.

My guest is Dr. David Fajgenbaum, MD, professor of translational medicine and human genetics at the University of Pennsylvania. He explains how, unbeknownst to most doctors, many approved medications can successfully treat or even cure diseases other than the ones they are typically used to treat. He shares his story of escaping death from Castleman's disease by discovering a life-saving treatment using repurposed drugs that were approved for other purposes. Our conversation explores how researchers, physicians, and you—the general public—can explore novel treatments and cures to conditions the medical profession has deemed untreatable, including cancers. We also discuss the crucial role of mindset in battling diseases and the lesser-known use of compounds to promote health and longevity. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman Eight Sleep: https://eightsleep.com/huberman Rorra: https://rorra.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman Timestamps (0:00) David Fajgenbaum (4:06) Self-Agency in Healthcare; New Uses for Old Medicines (6:44) Other Uses of Aspirin & Viagra; Drug Development & Approved Use (8:53) Lidocaine & Breast Cancer; Pharmaceutical Companies & Incentives (11:36) Sponsors: Eight Sleep & Rorra (14:16) Pharmaceutical Companies, Patents & New Uses; Lithium (18:40) Tools: Finding Reliable Health Sources, Asking Questions & Disease Organizations; DADA2 Treatment (21:53) Medical Community & Connections; Integrated Medical Databases (24:36) Drug Repurposing, Thalidomide, Pembrolizumab (28:45) Medical Research Databases, Mapping Disease Connections (33:51) Every Cure Database & Programs, Bachmann-Bupp Syndrome; Colchicine & Heart Disease (37:57) Sponsors: AGZ by AG1 & David (40:41) David's Medical & Career Journey, Glioblastoma, Castleman Disease (49:10) Autoimmune Disease, Driven Personality, Stress & Immune System (52:52) Castleman Disease, Treatment, Chemotherapy (55:54) Physician Continuing Education, Santa Claus Theory of Civilization; Science Collaboration (1:03:32) Medical School, Relapse & “Overtime”, Finding a New Treatment, Rapamycin (1:12:46) Sport, Football & Resilience; Challenge & Personal Growth, Family (1:18:41) Sponsor: Function (1:20:29) Social Support; “Overtime”, Gratitude (1:23:19) Business School, Castleman Disease Treatment; Repurposing Drugs & AI (1:28:29) Drug Repurposing, POEMS Syndrome; Mitigating Risk (1:35:32) Nicotine, Compounds for Preventive Health; GLP-1 Agonists (1:40:51) Bioprospecting, Drug Development; AI, Prioritization & Novel Connections (1:46:18) Healthcare & Children; Hope, Action & Impact Circuit; Challenge & Super-Agers (1:52:50) Get Involved with Every Cure (1:56:20) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications:1. Step Accumulation Patterns and Risk for Cardiovascular Events andMortality Among Suboptimally Active Adults – Annals of Internal Medicine 2025.  Discussion by:Guest:Kathryn Donnelly, DO Resident - Family Medicine Residency ProgramJefferson Health - Abington2. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Obesity – The New England Journal of Medicine 2025. Discussion by:Guest:Ajay Rau, MDChief - Section of Endocrinology, Diabetes and Metabolism Lewis Katz School of Medicine at Temple University3. Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation. New England Journal Of Medicine 2025.  Discussion by: Guest:Jasmin Walker, MD Resident – Family Medicine Residency Program Jefferson Health – AbingtonMedical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

This week, Gary, Kate, Mark and Henry discuss the optimal duration of anticoagulation after a provoked DVT, using low doses of mirtazapine or amitriptyline in adults with insomnia, whether a lower dose of semaglutide is still effective for weight loss, and adding aspirin for patients with coronary heart disease, a stent and who are also on a DOAC for another indication.Links:NICE Barrett Esophagus guideline: https://pubmed.ncbi.nlm.nih.gov/38553042/ Essential Evidence Plus: www.essentialevidenceplus.comDuration of anticoagulation: https://pubmed.ncbi.nlm.nih.gov/40888734/ Mirtazapine or amitriptyline for insomnia: ttps://pubmed.ncbi.nlm.nih.gov/39814428/ Lower dose semaglutide for obesity: https://pubmed.ncbi.nlm.nih.gov/40934115/ Adding aspirin: N Engl J Med . 2025 Oct 23;393(16):1578-1588https://pubmed.ncbi.nlm.nih.gov/40888725/

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter revisits the “proven, promising, fuzzy, noise, nonsense” scale and applies it to a variety of popular topics. He begins with a refresher on what each category represents before classifying a range of interventions based on the strength of their supporting evidence. The conversation spans three main areas: drugs for geroprotection (including GLP-1 receptor agonists, SGLT2 inhibitors, methylene blue, and telomere-lengthening supplements), the use of low-dose aspirin for cardiovascular disease prevention, and strategies to improve muscle mass through optimal protein intake and follistatin gene therapy. This episode provides a clear, evidence-based overview for listeners seeking to understand where these popular health and longevity interventions stand on the spectrum of scientific credibility. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #76 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: A scale for evaluating scientific claims: proven, promising, fuzzy, noise, or nonsense [1:30]; Strong convictions, loosely held: the mindset that separates great scientists from the rest [7:30]; GLP-1 receptor agonists: are there benefits beyond improving metabolic health and promoting weight loss? [12:45]; GLP-1 drugs and the brain: exploring the potential cognitive benefits [18:45]; GLP-1 drugs and lifespan: examining the evidence for potential geroprotective effects [23:00]; Rapamycin and geroprotection: why it remains in the “promising” category [25:45]; SGLT2 inhibitors and their potential geroprotective effect [27:30]; Methylene blue: examining the evidence of an anti-aging effect [34:45]; Methylene blue's potential neuroprotective effects: limited and inconsistent evidence in humans, and the challenges of dosing and safety [41:15]; Telomeres: what they are, how they relate to aging, and why telomere-lengthening supplements lack credible scientific evidence [43:45]; Does the idea of targeting telomere length to extend lifespan have scientific merit? [50:15]; Low-dose aspirin for cardiovascular disease prevention: weighing its clot-prevention benefits against bleeding risks across different populations [55:00]; Rethinking the protein RDA: why most people need twice the recommended amount for muscle health [1:00:45]; Debunking the protein–cancer myth: why higher protein intake doesn't promote tumor growth [1:06:15]; The biology of follistatin and myostatin, and why follistatin gene therapy has become an emerging topic of interest for muscle growth [1:13:15]; Follistatin gene therapy for muscle growth: state of the evidence in animals and humans, and the technical challenges and regulatory barriers [1:17:00]; Why injectable follistatin is theoretically possible but impractical for real-world use [1:23:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

People who've had colorectal cancer and have a known mutation should likely take aspirin to help prevent disease recurrence, according to a new study. The benefit of aspirin in preventing cancers has been shown before in the skin cancer melanoma, … Aspirin may be of benefit in a number of cancers, Elizabeth Tracey reports Read More »

For decades, clinical trial recruitment has been the biggest challenge in the industry. Christine Senn, senior vice president of Site-Sponsor Innovation at Advarra, offers insights into why the struggle continues, such as delays in getting regulations updated after a quarter of a century, and how to overcome the deadlock in clinical trial recruitment that is tied to current obsolete marketing guidelines. Also, host Deborah Borfitz shares the latest on beta blockers, low dose aspirin lowering the risk of recurring colorectal cancer, repurposing drugs for breast cancer relapse prevention, remote participation research on why athletes and military members face higher ALS risk, and the first agentic AI platform for life sciences from Medable. Show Notes News Roundup Rethinking beta blockers Press release on the Mount Sinai website Subgroup analysis study in the European Heart Journal Aspirin lowers risk of colorectal cancer recurrence Study in The New England Journal of Medicine  CLEVER study to prevent breast cancer relapse Study in Nature Medicine News release on Penn Medicine website   Champion Insights ALS initiative News release on Answer ALS website Medable's Agent Studio Press release on the Medable website Disseminating research findings Systematic review in PLOS Medicine  Guest Christine Senn, Ph.D., senior vice president of site-sponsor innovation at Advarra The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News senior writer, Deborah Borfitz, welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider's look at clinical research today.

NSFW Jokes - 07, Oct, 2025 Get the official NSFW Joke Button on here: https://amzn.to/4aF3dxR/ Episodes are produced every Monday and Thursday. Be sure to subscribe via your podcast app and get notified of new episodes! Search for "NSFW Jokes" in your podcast player! These jokes are sourced from reddit.com/r/dadjokes, /r/unclejokes, r/3amjokes and r/Jokes Joke credits: AdJaded9340, CrassTick, dadvsspawn, Upstairs_Breath9063, ReasonableGator, Joel_Boyens, Joel_Boyens, AccountantFront1560, TheGypsyThread, ReasonableGator, Cheap-Expression2853, onesole, PM_ME_UR_HANDBRA, pat85754

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning speaks with Dr. Anders Jeppsson, a cardiothoracic surgeon at Sahlgrenska University Hospital in Gothenburg, Sweden, about his paper on “Ticagrelor and Aspirin or Aspirin Alone After Coronary Surgery for Acute Coronary Syndrome,” published in The New England Journal of Medicine. Chapters 00:00 Intro  01:54 Ghana Mission Trip  06:23 JANS 1, Pig-to-Human Transplant  08:08 JANS 2, CABG Acute Type A AD  10:06 JANS 3, Chylothorax Lymph Node Management  11:22 JANS 4, ICU Resternotomy Adoption  13:38 JANS 5, Octogenarians Repair vs MV Surgery  15:10 Career Center  15:31 Video 1, MVR Patent Bilateral IMammary Grafts  16:36 Video 2, Repeat RA Thoracotomy  17:39 Video 3, Vascular Injuries in Robotics  19:12 Dr. Jeppsson Interview  33:30 EACTS 2025 & Upcoming Events  They began by providing an overview of the study, including the reason for conducting it, the expansion of the study to other Nordic countries, and its results. They also discuss the funding for the research and the recruitment process. Additionally, they cover dual antiplatelet therapy and compare this study with similar research. Finally, they explore registry-based studies and future research on ticagrelor and aspirin, or aspirin alone, following coronary surgery for acute coronary syndrome.  Joel also highlights recent JANS articles exploring whether protective coronary artery bypass grafting improves surgical outcomes in acute type A aortic dissection with coronary ostial involvement, the association of chylothorax with aggressiveness of lymph node management during pulmonary resection, if intensive care unit resternotomy should be practiced in all facilities that perform cardiac surgery, transcatheter edge-to-edge repair vs mitral valve surgery in octogenarians, and research using pig-to-human lung xenotransplantation into a brain-dead recipient.  In addition, Joel explores robotic mitral valve replacement in a patient with patent bilateral internal mammary grafts, repeat right axillary thoracotomy as a safe and feasible approach for repair of recurrent LAVVR after previous AVSD repair, and handling vascular injuries in robotic thoracic surgery. Before closing, Joel highlights upcoming events in CT surgery.    JANS Items Mentioned  1.) Protective Coronary Artery Bypass Grafting Improves Surgical Outcomes in Acute Type A Aortic Dissection With Coronary Ostial Involvement  2.) The Association of Chylothorax With Aggressiveness of Lymph Node Management During Pulmonary Resection  3.) Expert Opinion: Intensive Care Unit Resternotomy Should Be Practiced in All Facilities That Perform Cardiac Surgery  4.) Transcatheter Edge-to-Edge Repair Versus Mitral Valve Surgery in Octogenarians: Comparative Analysis of Safety, Durability, and Survival  5.) Pig-to-Human Lung Xenotransplantation Into a Brain-Dead Recipient  CTSNet Content Mentioned  1.) Robotic Mitral Valve Replacement in a Patient With Patent Bilateral Internal Mammary Grafts: A Case Video  2.) Repeat Right Axillary Thoracotomy Is a Safe and Feasible Approach for Repair of Recurrent LAVVR After Previous AVSD Repair   3.) Handling Vascular Injuries in Robotic Thoracic Surgery: Real-Life Cases Using a Fibrin-Based Hemostatic Technique  Other Items Mentioned  1.) Ticagrelor and Aspirin or Aspirin Alone After Coronary Surgery for Acute Coronary Syndrome   2.) Perfecting TAVR Removal | Skills Sharpening With Vince Gaudiani  3.) Career Center   4.) CTSNet Events Calendar  Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

In this episode, we review the high-yield topic of⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Salicylate/Aspirin Overdose ⁠⁠from the Pharmacology section.Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets

TARGET-FIRST: Early Aspirin Discontinuation After PCI in Acute MI Patients

Host Doug Stephan and Dr. Ken Kronhaus of Lake Cardiology (352-735-1400) cover a number of topics affecting our health. First up, Doug and Dr. Ken discuss the biggest news stories in the medical world, starting with a targeted itch-relief for the various types of bee/wasp/hornet stings, raising the question of what is in bee/hornet/wasp venom that causes pain, itching, as well as the more severe allergic reactions that can lead to anaphylaxis. Next up, new research linking prenatal exposure to acetaminophen (like in Tylenol) with Autism and ADHD and why some medical professionals are pushing back. Then, Doug and Dr. Ken continue the pain-reliever conversation and the benefits of routinely taking low-dose Aspirin, but the importance that a routine like this should be done under a doctor's supervision as there can be adverse effects if you are not someone that needs to be taking low-dose Aspirin regularly. Moving on, the focus shifts to brain injuries and how it affects young athletes, college-age and younger, with early neuron loss and CFE's. It's a finding that highlights long-term risk associated with sports, like football and soccer, leading to new guidelines for player safety and concussion protocols. More warnings on pregnancy and cannabis use, as use has climbed due to wider legalization and social acceptance, with many turning to marijuana to curb morning sickness and pregnancy pain symptoms. Lastly, new research explains a phenomenon how exercise suppresses appetite through a previously-unknown molecular pathway, questioning why bugs bite us, and the latest on the screwworm.  Website: GoodDayHealthrShow.com Social Media: @GoodDayNetworks

On February 4, 1941, Bronx police officers were called to the home of John and Catherine Pappas for a report of a homicide. Based on the evidence, detectives theorized that someone had been invited into the Pappas apartment while Catherine was home alone and that same someone had strangled her to death, then ransacked the apartment looking for valuables. To investigators the scene resembled a fairly straightforward robbery-homicide; however, to detective Ed Burns, there were elements of the crime scene that bore a striking similarity to another assault and robbery case he'd been assigned to just two weeks earlier in another part of the Bronx. What followed was an investigation that exploded in size from a single robbery-gone-wrong that resulted in a murder to a sprawling serial sexual assault case that would eventually involve more than eighty victims in eight states, all victimized by the same man. The hunt for the Aspirin Bandit is among the more remarkable cases in New York criminal history, not only because of the number of victims, but also because of the tremendous effort and coordination put forth to catch the killer—effort and coordination that, in 1941, was virtually unheard of.Thank you to the Amazing Dave White (of BRING ME THE AXE PODCAST) for research and writing assistance!ReferencesBrooklyn Eagle. 1941. "Papas slayer, faced by victims, confesses." Brooklyn Eagle, March 4: 1.Connor, Christine, and Elise Greven. 2017. "Gentleman Killer." A Crime to Remember. Janaury 3.Dillon, Edward, and Howard Whitman. 1941. "Cigarets, aspirin clues to woman's strangler." Daily News (New York, NY), February 6: 4.New York Times. 1941. "Alarm for burglar sent in Pappas case." New York Times, February 8: 32.—. 1941. "Cvek found guilty of Pappas murder." New York Times, May 20: 46.—. 1941. "Cvek tells court he killed in anger." New York Times, May 16: 24.—. 1941. "Mystery cloaks woman's murder." New York Times, February 6: 15.—. 1941. "Pappas strangler admits 15 crimes." New York Times, March 5: 1.—. 1941. "Slayer of woman 'rebukes' press." New York Times, March 8: 34.—. 1941. "Sun lamp halts trial." New York Times, April 22: 23.Rice, William. 1941. "Cvek a killer? No surprise to his relatives." Daily News (New York, NY), March 5: 4. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Program notes:0:40 Private equity takeover of hospitals1:40 Reduced salaries or staffing2:40 Patients likely to cost system3:30 Use of anti thymocyte globulin to slow down T1D in youth4:30 Diagnosed within 9 weeks prior5:30 Serum sickness in 82% of highest dose group6:30 Incidence increasing by 2% per year over 20 years7:00 Aspirin in CRC8:00 1100 patients with mutation9:00 Can this mutation be acquired?9:15 Alcohol and dementia10:15 Confounding factors relative to alcohol use11:15 Is there a safe level of consumption?12:40 End

Send us a textWelcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial looking at aspirin in patients with chronic coronary syndrome receiving oral anticoagulation. Here we go!Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (0:00 – 9:43).Throwback to EPIC-CAD: The Rounds Table Episode 94: Top Papers from the 2024 European Society of Cardiology Congress The Good Stuff:Trial Files is a free monthly newsletter on practice-changing trials, delivered straight to your inbox (https://trialfiles.substack.com/).Guidelines summaries coming to Trial Files soon!Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

NEO-MINDSET: Early Withdrawal of Aspirin After PCI for ACS

A large meta-analysis in The Lancet found clopidogrel superior to aspirin for long-term secondary prevention in coronary artery disease, reducing major cardiovascular events by 14% without added bleeding risk. The REBOOT trial in NEJM showed no benefit of beta-blockers in post-MI patients with preserved ejection fraction, and even potential harm in women on high doses, prompting reevaluation of routine use. Finally, a phase 2 trial in JAMA Internal Medicine showed daily azelastine nasal spray reduced COVID-19 incidence by 67% and shortened illness duration, though larger studies are needed to confirm its prophylactic role.

-Cause & effect of chronic illness-Mold exposure, toxicity, & testing your home & remediation-Polio-Heart disease (CVD)-Magnesium-Reversing blockages in arteries-Cholesterol is not the villain-Aspirin vs. Neprinol-Healing IBS To find out how we can help you on your health journey, book a free 15-minute Discovery Call with one of our New Client Coordinators! Click the link: https://www.spiritofhealthkc.com/discoverycallFor more health tips and information visit: http://www.spiritofhealthkc.comTo buy natural health supplements visit: http://store.spiritofhealthkc.com To find out how we can help you on your health journey, book a free 15-minute Discovery Call with one of our New Client Coordinators! Click the link: https://www.spiritofhealthkc.com/discoverycall For more health tips and information visit: https://www.spiritofhealthkc.com/To buy natural health supplements visit: http://store.spiritofhealthkc.com Facebook: https://www.facebook.com/SpiritofHealth/ Instagram: https://www.instagram.com/spiritofhealthkc/ Pinterest: https://www.pinterest.com/spiritofhealthkc/YouTube: https://www.youtube.com/channel/UCwRcNSxR3kMYi9wP8OmxlQQ Spotify: https://open.spotify.com/show/7yfBBUjWKk3yJ3auK71O7H?si=295c77ed21f14568&nd=1&dlsi=af01c00121ed4aed

The Defense Department has finalized the core rule for its Cybersecurity Maturity Model Certification program, laying out how contractors must safeguard sensitive data. While the framework is now official, the rollout may hinge on the readiness and capacity of third-party assessors. Here to explain what's in the rule and what comes next is , partner at Hunton, Andrews, Kurth--Eric Crusius.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Millions of us take aspirin daily to ward off heart attack or stroke, but a new study has found an alternative blood thinner, clopidogrel, could be more effective. We find out how it compares.An oral health check-up at least two weeks before surgery has shown to reduce the risk of post-operative infections such as pneumonia as well as reduce the length of a patients' hospital stay. Dr Kristina Wanyonyi-Kay Research Programme Leader at The Healthcare Improvement Studies Institute at the University of Cambridge assesses what this Japanese study tells is about the connection between oral health and the rest of our bodies.The Africa CDC and WHO have just launched ambitious targets to cut Cholera by 90% across Africa. Global health journalist Andrew Green assesses if this target is likely to be met with the measures proposed.We meet a Chilean football team who've all had organ transplants. They're trying to raise awareness and improve the number of donors in the country. Our reporter Jane Chambers went to Santiago to find out more.Could music help or worsen travel sickness? A study in China found happy music improved symptoms whilst sad music made them worse.Presenter: Claudia Hammond Producers: Katie Tomsett & Hannah Robins

Review of aspirin's mechanism of action, indications, contraindications, and administration for patients with acute coronary syndrome (ACS) or stroke.Aspirin's mechanism of action & benefits for Acute Coronary Syndrome (ACS) patients.Contraindications and considerations for aspirin's use.The dose and route of administration of aspirin for ACS patients.The use of aspirin in the ACLS Stroke algorithm.**American Cancer Society (ACS) Fundraiser This is the seventh year that I'm participating in Men Wear Pink to increase breast cancer awareness and raise money for the American Cancer Society's life-saving mission.I hope you'll consider contributing.Every donation makes a difference in the fight against breast cancer! Paul Taylor's ACS Fundraiser Page: http://main.acsevents.org/goto/paultaylorTHANK YOU for your support! Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Have you been told to take a daily baby aspirin to protect your heart?     What if that common advice isn't as beneficial—or safe—as it seems?     And, what if there was an even more effective dosing schedule of aspirin for those that want to partake?     I'll also share the natural alternatives we use in our practice to support heart health safely.     So join me on today's Cabral Concept 3476 to learn why other approaches may work better than daily baby aspirin.      Enjoy the show, and let me know your thoughts! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3476 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

In this fascinating episode, you’ll get to explore some eye-opening insights that can transform your approach to health and daily living. You’ll discover how I unexpectedly gained nearly 20 pounds of muscle—without major changes to my training—just by increasing my intake of collagen and essential amino acids, and how you can apply this strategy yourself. You’ll also dive into shocking new research on smartphone addiction and brain activity, learning about both the risks and surprising cognitive benefits of tech use, plus how music therapy and analog habits like memorization and family games can help keep your mind sharp. Whether you’re a biohacker, a health enthusiast, or simply someone looking to live a more boundless and fulfilling life, this episode will give you actionable tips, science-backed insights, and real-world strategies you can start applying today. Full show notes: https://bengreenfieldlife.com/490 Episode Sponsors: Truvaga: Balance your nervous system naturally with Truvaga's vagus nerve stimulator. Visit Truvaga.com/Greenfield and use code GREENFIELD30 to save $30 off any Truvaga device. Calm your mind, focus better, and recover faster in just two minutes. Our Place: Upgrade to Our Place today and say goodbye to forever chemicals in your kitchen. Go to fromourplace.com and enter my code BEN at checkout to receive 10% off sitewide. Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20–25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. BIOptimizers Mushroom Breakthrough: A blend of four mushrooms and collagen that gives you maximum brain power, healthier skin, hair and nails, and supports the immune system. Go to bioptimizers.com/ben now and enter promo code BEN10 to get 10% off any order. Timeline Nutrition: Give your cells new life with high-performance products powered by Mitopure, Timeline's powerful ingredient that unlocks a precise dose of the rare Urolithin A molecule and promotes healthy aging. Go to shop.timeline.com/BEN and use code BEN to get 20% off your order. See omnystudio.com/listener for privacy information.