Podcasts about cyp

In this episode, we review the pharmacology, indications, adverse effects, monitoring, and unique drug characteristics of angiotensin receptor blockers (ARBs).  Key Concepts ARBs are equally efficacious as ACE inhibitors when used for hypertension, heart failure with reduced ejection fraction (HFrEF), chronic kidney disease (CKD) with proteinuria, and post-MI care. Some limited evidence suggests that they might be better in reducing albuminuria in patients with diabetes. ARBs are generally better tolerated than ACEi due to a lower risk of angioedema and dry cough.  While most ARBs are comparable to each other, small differences exists regarding hepatic metabolism (CYP metabolism for losartan, telmisartan, and azilsartan), degree of blood pressure lowering (generally better with azilsartan, olmesartan, valsartan, and candesartan), and additional pharmacological effects (telmisartan with PPAR-Y agonism, losartan with uricosuric effect). ARBs are contraindicated in pregnancy, those with bilateral renal artery stenosis, and those with previous angioedema to ARBs. The most common adverse effects include hypotension and hyperkalemia, but in rare cases acute renal impairment can also occur. Baseline serum creatinine and potassium should be monitored in patients taking ARBs. After initiation or dose adjustment, blood pressure, serum creatinine, and potassium should be repeated in 1-2 weeks. Signs and symptoms of hypotension as well as angioedema should be monitored throughout the treatment period.

In this episode of the SENDcast, Dale discusses informal SEND provision in mainstream primary schools with Kate Browning, an experienced SEND consultant. They explore the increasing demand for inclusive education amid a rise in children with complex needs and the challenges schools face in effectively supporting these students. Kate highlights what good practice looks like when thinking about establishing an informal SEND provision and what the potential dangers and unintended consequences are.  Key points include:  Growing Inclusion Needs Parental Choice vs. School Capability Positive Impact of Informal Provision Importance of High Expectations Collaborative Support Normalisation of Differences “Share, develop, widen, broaden and resource appropriately so that we can really evolve what that mainstream education offer can look like.” Kate Browning Overall, the episode highlights the importance of thoughtful implementation of informal provisions and the need for ongoing support and collaboration to ensure all children can succeed in inclusive educational settings. About Kate Browning For over 25 years, I have been passionately committed to supporting schools to improve outcomes for children and young people with SEND. Over this time, I have worked as a SENCo, a SEN Advisory teacher, a Local Authority School Improvement Officer for SEND and interim Education Development Officer for NASEN. I now work as an independent consultant specialising in school improvement for SEND.   I have supported NASEN in writing guidance and delivering national training on the SEND Code of Practice for SENCOs. I have a successful track record of working with individual schools Trusts and Universities to improve outcomes for children and young people with SEND thorough consultancy, training and producing written guidance. I also support Local Authorities in reviewing and developing their strategy for identifying, making provision and improving outcome for CYP with SEND.   I taught the National Award for SEN Coordination and now teach on the NPQ SENCO. I facilitate SENCo Networks for schools across Leicestershire, Warwickshire and Coventry. I am an experienced Chair of Governors and SEND Governor of a large Junior school. My approach is wholly collaborative, positive and focused on empowering those I work with to make a sustainable difference to improving outcomes for children with SEND.  Contact Kate kate.browning2@gmail.com www.x.com/@kate_browning2 Useful Links B Squared Website – www.bsquared.co.uk  Meeting with Dale to find out about B Squared - https://calendly.com/b-squared-team/overview-of-b-squared-sendcast  Email Dale – dale@bsquared.co.uk  Subscribe to the SENDcast - https://www.thesendcast.com/subscribe The SENDcast is powered by B Squared We have been involved with Special Educational Needs for over 25 years, helping show the small steps of progress pupils with SEND make. B Squared has worked with thousands of schools, we understand the challenges professionals working in SEND face. We wanted a way to support these hardworking professionals - which is why we launched The SENDcast! Click the button below to find out more about how B Squared can help improve assessment for pupils with SEND in your school.

Before I share the replay of this open coaching call I want to tell you… Wednesday, April 2nd is the last day to sign up for Create Your Program in 2025. Do you have a sense of what having your own course or program could do for your career? If you've been sitting on an idea for a while, I want to invite you to create your program with me. This is the process where you take your incredible strengths as a therapist or healer and you create a signature program so that you can serve more people, make more money, and get your best ideas out of your head and into a unique container you'll be able to offer over and over. We go through an 11 week process together step by step so that you are actually launching your program during our time together with my support. I ran a free and open coaching call recently for everyone in our audience, including clients and listeners. We had such great questions that I decided to share the recording with you. Here are some of the questions I answered and expanded on: Can I create my first program with minimal tech? How can I carve out time to work on my program when I've got a full private practice? I have a few ideas for programs. How can I choose one? Is it best to wait to do CYP until I have a fully formed program idea, or do plenty of people figure it out along the way? How do you support therapists like me who are constantly taking courses and never creating? How far in advance of my course should I start promoting it? I sometimes think “I have no good ideas.” How do I get past this and tap into an offer I feel clear and confident about? How do you support therapists in being visible. I'm worried how my therapy clients might react if I share more of my personal story in a newsletter. With the economy quickly changing, how do we factor that in as we choose which program to create? Show notes at https://rebeltherapist.me/podcast/243

Contributor: Jorge Chalit-Hernandez, OMS3 Educational Pearls: CYP enzymes are responsible for the metabolism of many medications, drugs, and other substances CYP3A4 is responsible for the majority Other common ones include CYP2D6 (antidepressants), CYP2E1 (alcohol), and CYP1A2 (cigarettes) CYP inducers lead to reduced concentrations of a particular medication CYP inhibitors effectively increase concentrations of certain medications in the body Examples of CYP inducers Phenobarbital Rifampin  Cigarettes St. John's Wort Examples of CYP inhibitors -azole antifungals like itraconazole and ketoconazole Bactrim (trimethoprim-sulfamethoxazole) Ritonavir (found in Paxlovid) Grapefruit juice Clinical relevance Drug-drug interactions happen frequently and often go unrecognized or underrecognized in patients with significant polypharmacy A study conducted on patients receiving Bactrim and other antibiotics found increased rates of anticoagulation in patients receiving Bactrim Currently, Paxlovid is prescribed to patients with COVID-19, many of whom have multiple comorbidities and are on multiple medications Paxlovid contains ritonavir, a powerful CYP inhibitor that can increase concentrations of many other medications A complete list of clinically relevant CYP inhibitors can be found on the FDA website: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers  References Glasheen JJ, Fugit RV, Prochazka AV. The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens. J Gen Intern Med. 2005;20(7):653-656. doi:10.1111/j.1525-1497.2005.0136.x Lynch T, Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am Fam Physician. 2007;76(3):391-396. PAXLOVID™. Drug interactions. PAXLOVIDHCP. Accessed March 16, 2025. https://www.paxlovidhcp.com/drug-interactions Summarized & Edited by Jorge Chalit, OMS3 Donate: https://emergencymedicalminute.org/donate/  

#borderwars #thaboxingvoice #tbvpodcast ☎️Border Wars 15: Betting Line Open Keem -115 Vs. CYP -105

#borderwars #thaboxingvoice #tbvpodcast ☎️Border Wars 15: Betting Line Open Keem -115 Vs. CYP -105

In this episode, hosts Drs. Temara Hajjat and Jenn Lee talk to Dr. Rachel Chevalier. Dr. Chevalier is a pediatric gastroenterologist and physician scientist at Children's Mecy Hospital. She is an Associate Professor at the University of Missouri-Kansas City School of Medicine. In this episode, we'll explore treatment options for eosinophilic esophagitis, discuss steroid complications and emerging therapies, and dive into the role of drug metabolism and genetics in optimizing patient care. Learning Objectives:Discuss available corticosteroid options, dosing strategies, administration techniques, and challenges like insurance coverage and FDA limitations.Highlight potential complications of steroid use, mitigation strategies, and emerging treatments like orodispersible tablets.Explain the role of CYP enzymes, genetic variability, and personalized approaches to optimize treatment based on Dr. Rachel Chevalier's research.Support the showThis episode may be eligible for CME credit! Once you have listened to the episode, click this link to claim your credit. Credit is available to NASPGHAN members (if you are not a member, you should probably sign up). And thank you to the NASPGHAN Professional Education Committee for their review!As always, the discussion, views, and recommendations in this podcast are the sole responsibility of the hosts and guests and are subject to change over time with advances in the field.Check out our merch website!Follow us on Bluesky, Twitter, Facebook and Instagram for all the latest news and upcoming episodes.Click here to support the show.

Today's guest is a grad of CYP. If you want this to be the year you finally launch your course or make a pivot to coaching, do what she did. Get my support in a step-by-step process to create and launch it. Head over to https://rebeltherapist.me/. Don't know what your topic will be? No idea where to start? You'll be in good company. You do have a program in you. As this is going live, you can still get into the cohort that's about to start. You'll be launching your course by a few months from now. If you're too late, get on the notification list for next time. That's https://rebeltherapist.me/create Now to today's conversation: Dr. Jenn Kennedy is a clinical sexologist and licensed marriage and family therapist based in Santa Barbara. Dr. Jenn supports clients in the areas of relationships, sex, addiction and LGBT. In 2023, Dr. Jenn launched The Pleasure Project, which is dedicated to helping us all have a better sex life. Through this venture, Dr. Jenn hosts a podcast called Pleasure Project: Sex & Relationships and she offers small group intensives for women and couples. She is coming out with an asynchronous course in 2025. Dr. Jenn has been quoted in Redbook, Reader's Digest, Forbes Health, DailyOm, Shondaland, Parade, Allure, Yahoo!life and others. She is often tapped to discuss intimacy and sexuality for therapists and physicians. And she's a grad of Create Your Program. You're about to hear why she created a program called The Pleasure Circle, to help women who want to want sex more. Here's some of what we talked about: Creating a program for women 40 and over about desire Emotional barriers Dr. Jenn experienced in creating and sharing the program Getting feedback partway through and making adjustments each time How she handles sharing her personal stories (which she does more of in this program than in therapy). Being out as lesbian How she markets her program and brings in participants Annie coaches Dr. Jenn on a pain point around making sales calls Show notes at https://rebeltherapist.me/podcast/237

Stop waiting for something outside of you to change - you are the new beginning. In this episode, we're getting real about why nothing changes if nothing changes—and how to take your power back starting right now. You already have everything you need to create the life you want. Let's talk about shifting your energy, breaking out of waiting mode, and claiming yourself as the catalyst for your own transformation. This is your reminder: it all starts with you. 2025 LIVE Manifestation Workshop on Jan 4th!

Your focus is your superpower, and in this episode, we're breaking down how to use it to completely transform your life. I'm sharing the science and spirituality behind why what you give your energy to grows—and how to shift from focusing on lack to creating more abundance, love, and alignment in your reality✨

Sometimes, the hardest thing to do is walk away from what no longer serves us. In this episode, we dive into the power of letting go and creating space for what's truly meant for you. Tune in to learn how walking away isn't just an ending—it's the beginning of your next chapter❤️ This episode is brought to you by BetterHelp. Give online therapy a try at betterhelp.com/cyp and get on your way to being your best self❤️ Get 15% off OneSkin with the code [CYP] at https://www.oneskin.co/ #oneskinpod JOIN CLAIM YOUR POWER FREE WHATSAPP CHAT (a safe space for like-minded women to connect

Wednesday, November 20th is the last day to sign up for early access to create your program. Do you have a sense of what having your own course or program could do for your career? If you've been sitting on an idea for a while, I want to invite you to create your program with me. This is the process where you take your incredible strengths as a therapist or healer and you create a signature program so that you can serve more people, make more money, and get your best ideas out of your head and into a unique container you'll be able to offer over and over. We go through an 11 week process together step by step so that you are actually launching your program during our time together with my support. Head to https://rebeltherapist.me/create to enroll now. I ran a free and open coaching call recently for everyone in our audience, including clients and folks on my email list. We had such great questions that I decided to share the recording with you. Here are the questions I answered and expanded on: What questions should I ask myself to decide what kind of program to create? Do you think in-person or online programs are more in demand right now? Are there any prompts or guidance on how to go about spotlight coaching on group calls? Do I have to set up coaching programs separate from my therapy business? What goals should we aim for when starting a group? How many members? Cost? Time commitment? What's the best way to fill the group? What are some great niches for women's groups in particular? And what makes a great niche? Do therapists need to be trained as coaches? How do you go from a general to a more specific niche topic? Is trauma healing specific enough? How would you get more specific? If I'm trying to reach people across the country or world, does it still make sense to build up local connections and local networking? The idea of creating a group program and running a group call makes my head explode. Do you have any sense of if individual or group programs tend to be more successful in enrollment? For group programs, how essential is it to use social media as a tool to grow our niche community? Might it work to write articles and listicles as a way to grow my audience? Do I need some type of insurance for liability if I decide to switch from therapy to coaching? Plus we hear from a grad of CYP about an experiment she has been running in her business. Show notes at https://rebeltherapist.me/podcast/234

Sometimes, life has a way of guiding us, even when we feel lost or frustrated. Those detours, delays, and unexpected changes aren't just random—they're often signs that something greater is unfolding. In this episode, we're diving into the 6 subtle—and sometimes not-so-subtle—signs that life is redirecting you toward the path meant for you

November Q&A...but special this time because it includes you guys! I asked you a couple weeks ago on my Instagram to submit me a voice memo with your question and I incorporated it into the episode, I hope you guys love it❤️ This episode is sponsored by BetterHelp. Give online therapy a try at betterhelp.com/CYP and get on your way to being your best self Resource For You✨

Today I'm talking about how to run engaging and effective group calls in your signature program, rather than calls that leave people bored or frustrated or just not showing up. When I say PROGRAM, I'm talking about a niched, outcome oriented, structured container. Your program might be a workshop, retreat, group coaching program, course, or some hybrid of different formats. These are the kinds of programs that are always in demand because they actually help people make significant transformations. I'm not talking about flimsy self-led courses here. I'm talking about programs where your participants get to interact with you in a meaningful way. Therapists and healers make the best programs. We've got training and experience in how to help people get from point A to point B. We know how to work with resistance, emotions, and all of the other things that make change difficult. If you've been a participant in a lot of programs, you know that some group leaders have no idea what they're doing! You as a therapist or healer have the potential to be a very skilled group leader for your program. BUT there's some stuff that therapists also need to learn about running calls in their structured, niched and outcome oriented programs. A question I get a lot is: “How can I facilitate group calls well in my new program?” And I'm excited to share my answer with you here. THE TROUBLE WITH THERAPISTS Our biggest mistakes as therapists are that we tend to run our program calls like group therapy sessions when we need to be doing something different. I'll use myself as an example. I really fucked this up at the beginning. In the beginning, I ran my program calls a lot like group therapy sessions, and that wasn't what my business coaching program needed. I tended to go towards depth and bigger emotional material because I was comfortable there and that's what I was used to doing with groups. I had been moving that way during years and years of working as a therapist. If a person brought up feeling stuck in perfectionism or imposter syndrome, I'd expand and encourage that conversation to the point that it took up most of the session. Then I'd try to rush through some business concepts. I didn't know how to balance that beautiful depth with the need to direct the group towards the goal of the program. My group calls left people feeling understood, bonded to others in the group, and probably with less shame about their experiences. The calls didn't give the participants enough help with taking strategic steps in their businesses. Were the calls bad? It depends what you think the purpose of the calls was. People who primarily wanted space to process about their emotions about their businesses probably thought the calls were great. People who wanted to move forward with strategy probably felt frustrated. Lots of participants probably felt pretty good about the calls while they were happening, but then bummed out at the end of the program that we hadn't gotten enough business stuff done. As therapists, we still get to use our attunement skills, but we need to harness them differently. The problem was that I hadn't chosen ONE clear purpose for my calls. CHOSE A PURPOSE That brings me to one of my favorite thought leaders around running groups: Priya Parker. She's an author and a facilitator, and she's NOT a therapist. Her book, The Art Of Gathering, has changed how I think about groups forever. Priya Parker says that for any gathering, you need to choose ONE clear purpose. You definitely need one clear purpose for your program. The purpose of your program is the outcome it helps people move towards. For example: Let's pretend your program helps couples in blended families to strengthen their relationships. (That's a juicy niche by the way. Grab it if you want!) This program is designed to get the couple from point A to point B. Point A is where the couple is now, feeling distress in their bond. point B is feeling stronger in their relationship. Every single decision you make about your program should be in service of helping your couples towards the goal of a stronger relationship. Your whole program has a purpose. Within that program, each of the group calls needs to have one clear purpose as well. For each session, you can ask yourself: “What is the one thing that this call needs to do well?” Is the purpose of each meeting to internalize a concept? To feel connected to other participants? To hear each other's stories? Choose ONE purpose to build the call around. Yes, they'll get additional benefits out of those meetings too. But choosing just one purpose saves us from this bias we all tend to have. We overestimate our ability to prioritize lots of things at once and do all of them well. That's when calls get boring and frustrating for the participants, and you notice that people stop showing up. That's also when you as the leader get stressed out and maybe even resentful. You're trying to do SO much and it's not working. Here's something I hate to hear from the leader at the beginning of a workshop or a meeting: “We've got way more stuff to cover than we have time for!” We've all learned to humble brag about being over committed and doing too much, but when a group call doesn't have enough time to accomplish the goal, it's just not as valuable. RUN YOUR CALLS IN A WAY THAT PROTECTS THE PURPOSE Once you know the purpose of the program and specifically of each of calls, it's your job to protect that purpose. When people signed up for your program, you promised them a process to get from point A to point B. I'm gonna talk about some things you can do in structuring your calls to make that happen. THINGS TO DO ON THE FIRST CALL Your first meeting will be different from the subsequent ones because the purpose of the first call is to get everyone set up for success in the program. (If what you're running is a multi-hour workshop or a retreat, this applies to the beginning of that event.) Start on time. If you wait to start until everyone has arrived, people will take that cue and show up late next time. Don't start the first meeting with logistics because that's a missed opportunity. Start the very first moment of the very first meeting with something that brings people into more presence. Logistics can be the second thing you do. You might start with a breathing exercise, an inspiring story, or a simple experiential exercise. Name and ask for acknowledgement of group agreements. Ask participants to share other desired agreements, and allow them to email you with suggested additions if they don't want to bring them up in the group. Tell people how you'd like participants to behave on the group calls. Talk explicitly about what's in the range of desired behavior, including things like eating, turning their cameras off, coming late or leaving early. There's no one right answer to these things, so you need to tell them what's expected here. Model taking care of yourself. For example, take a sip of water and stretch when you need to. Tell people to expect that you'll interrupt them sometimes, always with loving kindness, because you're going to be driving this bus towards a particular direction. Tell people what kinds of feedback or comments are welcome. Unlike in a therapy group, their feedback to each other might not be the priority on these calls. If that's the case, tell them. Tell them how to get the most out of these calls and the whole program. If there's homework, give them a sense of how much time that will take, and help them plant seeds for themselves about how they'll get that done and what they'll do if they fall behind. STRUCTURING THE REST OF YOUR CALLS Start with a ritual in each meeting to help people arrive. Briefly tell people after that ritual what will happen during that call. When that plan changes partway through the call, acknowledge that you're pivoting. They won't care that you're pivoting. They'll just be glad you're still driving the bus. If you've got multiple group calls, a structure that often works well is one portion for teaching, then a portion for spotlight coaching or discussion. 90 minutes tends to be a good length for calls where both teaching and discussion and coaching happen. If you've got 6 people or more, breakout rooms of 2 or 3 people can be a helpful tool for discussion. When you use breakout rooms, give them a prompt and tell them to use the time as feels best. When you're teaching something, teach! Keep the focus rather than going into too much discussion in the middle of teaching. Every time you teach a concept, include something experiential so that participants can grapple with what they're learning. That could be as simple as pausing for silent reflection or journaling. You could fill in a worksheet together. You could lead folks through a visualization. Try to show a visual like a slide every time you teach a big concept. You might include spotlight coaching in place of or in addition to more open ended group discussion. This might move you away from your comfort zone if you've been a group therapist. In spotlights, you coach one person in front of the group. If you've got a lot of expertise in this topic, and people have paid big bucks to learn from you, so don't shy away from spotlight coaching. Sometimes therapists are so used to saying “you're the expert on you” or “the group has all the wisdom” that we don't step into our authority enough. Return to the purpose of your group call. If spotlight coaching will fulfill that purpose better than open ended discussion, do it. Remember when you said you'll interrupt in order to protect the purpose of the calls? As someone is talking, it is YOUR job to decide if this discussion serves the purpose of the call. If it doesn't, explain that kindly and move on. On the other hand, If what's happening with a person does serve the purpose particularly well, you might spend MORE time on one person's spotlight. At the end of your very last session, do something that brings people into being present, not logistics. That means you'll need to talk logistics before the end. EXPERIMENT WITH DIFFERENT STRUCTURES I'm a participant in a group right now in which we learn and internalize a new concept each week. The leader summarizes in one sentence what she would like us to internalize. Then she teaches on that. Then we have a discussion to further internalize the concept. In my container, Create Your Program, people do all of the short video lessons and work between sessions. By the way, I do NOT recommend that you prerecord videos. I recommend that you teach everything live at least the first time you run your program. I taught CYP live many times before I recorded the curriculum. In CYP, the purpose of the weekly calls is to move through obstacles to getting your program created and launched. The structure of most of my calls is a quick ritual, then spotlight coaching, and sometimes a 10 minute breakout with groups of 2 or 3. People get other benefits from the calls, but by focusing on that one purpose, I know the calls do that one thing really well. I've also been a participant in a group where we met two times a week. One session was all about learning a concept, and the other session was for discussion and Q&A. DIFFICULT MOMENTS Handling difficult moments might come easily to you as a therapist. We know how to have some really tricky conversations while staying present. One difficult thing you'll deal with is shame. Your participants will sometimes experience shame during calls because they're learning big stuff and making changes. Rather than expanding in that direction, which might be too much for the container, you might want to normalize and contain shame. You're containing the group process, not the person. One way to do that is to say out loud what you see in others (” I see lots of head nods” or “I see a lot of resonance on people's faces”) to show that the person is not alone in their experience. You can also name it if you have struggled in a similar way yourself. If a participant seems to be in fight or flight or freeze, you might acknowledge that things got big, and that this is big stuff. Name that you'll circle back with the person if that feels right. Don't feel you have to tie a bow on every interaction. You won't always be able to fix or resolve everything, and that's OK. When you're the one who gets dysregulated, especially if you cause any kind of harm, name it. Say “that was about me.” Don't over apologize, because then participants are likely to feel they need to take care of you. Circle back next time if you've got more accountability to take. Even if you're not normally available between calls, you'll need to be available if a conflict happened and harm happened. Now remember what I said about talking about homework in the first session? It's gonna come up in subsequent sessions. If you've got a program where there's homework, you'll need to acknowledge many times that it's hard to get the work done. Whether you give 5 minutes of homework or 3 hours of homework, it will be hard for people to get it done. If there's any way to get people to the outcome without homework, don't assign homework! This is gonna go against your therapist sensibility, but you've got to contain the conversation around how hard it is to get the homework done. Don't allow your program to become a group only about how hard it is to do the homework. That will not serve the purpose of the group. In my program, there's a LOT of homework. The homework is broken down into bite sized pieces, but it's a lot, because people are creating their programs. I have a lot of practice at normalizing the struggle to get things done, and strategizing with people about what to prioritize and what to let go of. BE WILLING TO BE LESS LIKED This is something you might already be good at as a therapist. Running a group program is great for getting over people pleasing because you can't people please 4 or 8 or 25 people at once. I used to have the habit of scanning for the person who looked least happy on the call and focusing on them. I rarely do that anymore. Partly because I've done a lot of trauma healing recently and partly also just because I'm 52, I just don't need everyone to like me at every moment. It's also helped me to be a participant and watch group leaders who don't take it personally when someone is struggling or unhappy in the moment. I've noticed how calm that makes me feel. I've watched myself as a participant and noticed when I'm the “difficult person”. It's fine and helpful to be redirected in those moments. When someone else is the “difficult person”, it's very comforting to watch the group leader handle it with compassion and clear boundaries. I work to allow myself to be a conduit for anger, frustration, or whatever a participant might need to feel in a particular moment. It's always generous to protect the purpose of the group. Therapists and healers really do create the best programs. Once you harness what you're already great at and grow your skills around this particular kind of facilitation, my prediction is that you're going to be hooked on running group programs. The energy and mutual support that happen make group calls my favorite part of my whole job. Show notes at https://rebeltherapist.me/podcast/233

Warning.........We start this month with a rather embarresing moment as Mark delves into his porn collection stories and how his hiding spot got rumbled by his mum during his absence in America. We soon get back on track with a dissection of Gaz and Elliotts recent underwater film series, Submerge on CYP. We discuss line angles, colour, teritorial carp, rigs and hooked ratios, a must watch and a superb series. Following on from our usual ramblings we have an epic special guest, the big carp Ninja, Matt Townend.  Most will know Matt from his editorial days at Total Carp but he's also got an album of big carp that he rarely talks about. I got a chance to pick his brains on his free lining approach and talk through a vintage year that saw Matt catch some incredible Colve Valley carp to over 50lb, a serious achievement by such a humble guy and one that rarely shouts about his successes. Enjoy. 

This month I caught up with Elliott Gray and jumped straight into his Burghfield campaign. A challenge that's seen him invest alot of time in search of what many believe to be the pinnacle of carp here in the UK. As you'll get to hear, his first year on this ball breaking venue resulted in some incredible carp, doing things his own way and keeping focussed on a plan that came good in the end. We also delve into some recent changes to CYP and why Elliott and Rich decided to re-brand this popular stream of content and focus heavily on underwater filmmaking. El is always open and honest with his opinions and views and considering he's hardly spoken about his own fishing in recent times it was great to hear his trials and tribulations in search of the BC. In addition me and Mark somehow delve into the world of cremation, having both experienced some rather random moments with relatives ashes. However, we do discuss the recent Korda underwater episode and delve into how our carp fishing has changed over the years since the arrival of kids! Enjoy. 

In today's episode, taken from live recordings at PREMIER 2024, we dive into an increasingly common treatment for type 1 diabetes: hybrid closed loop insulin pumps. We'll begin with a brief overview of traditional insulin pumps and explain how hybrid closed loops are different. The core of our discussion will be centered around three case studies, illustrating potential scenarios you might encounter in a pediatric emergency department and how to manage them effectively. With NICE's recent technology appraisal advocating for universal access to hybrid closed loop systems for all type 1 diabetes patients, it's crucial to understand these devices. Over the next few years, you'll likely encounter these systems frequently. We'll cover the essentials of how these pumps work, their benefits, and potential issues that might arise, such as connectivity problems, cannula issues, and handling intercurrent illnesses. Join us as we explore the revolutionary impact of hybrid closed-loop systems, which offer better glucose control and significantly improve the quality of life for those with type 1 diabetes. Dr Nicola Trevelyan has been the Clinical Lead for the Paediatric Diabetes Service in Southampton for the last 20 years. During this time, she has seen huge changes in the management of CYP with diabetes.  She has been involved in several large multicentre trials for paediatric diabetes,  helping to better our understanding of how best to use new technologies in diabetes management in children and move forward access to new treatment technologies.  She was one of the founding committee members for the Assoc of Children's Diabetes Clinicians (ACDC) in 2006 and has been on working parties for BSPED helping evidence base and re-write the national DKA guidelines in 2020 and for the National Paediatric Diabetes Audit.  For the last 4 years, she has been on the Clinical Advisory Group for the RCPCH Quality Improvement Programme for Paediatric Diabetes. 

This is a short episode and it's really about you giving yourself permission to do the work that is going to feel most joyful and sustainable for you. I'm going to talk about two different roles we might choose for ourselves as therapists, healers and coaches: A catalyst who helps people through a big and clear change in a particular area of their lives. OR An integrator who helps people grow and maintain changes over a long period of time in many areas of their lives. I know there's a lot of overlap and nuance between these 2 roles. Therapists I work with who want to create signature programs beyond private practice often want to be in the role of catalyst more of the time, and long-term integrator less of the time. They're feeling over-full on the long-term work of helping their clients day-by-day, week-by-week, month-by-month and year-by-year. They value that long-term work and are honored to get to do it, but they fear that if they keep doing it full time, they're going to burn out, or maybe just not love their work so much. In the programs they create, these therapists want to be in the role of short-term change catalyst. They want to step further into their role as teacher, presenter, and facilitator. They want to create a container that moves participants through a process of profound growth in a particular area that they really care about. The topics of these programs include: sexuality, relationships, parenting, money, business, and particular life experiences like divorce and grief…and on and on. I'll give you a few examples of programs folks have created in a minute. These programs are time-limited, usually happening over a number weeks or just a few days. These therapists find it satisfying to watch their people have big insights and make big changes and progress in their programs. But when folks are getting ready to create their programs, they sometimes think… “Wait a minute. Even if I help people create a lot of change quickly, maintaining those changes takes long-term work. It's not just one and done. So then is my program valuable enough if it doesn't help people through the long-term maintenance of that change?” Here's my answer: YES. The focused change your program creates is highly valuable. Both kinds of work are totally valuable and necessary. Neither kind of work is more or less valuable. As a therapist, I was trained with a bit of either/or thinking. I remember learning that REAL change takes time, and that rapid change is probably fleeting. Perhaps as therapists, sometimes this is a defensive stance. Sometimes the long-term, subtler work of a therapist doesn't get enough credit because it's less obvious than the change that happens during something like a retreat or a workshop. But you, my friend, are not going to devalue that long-term work. AND you still might not always want to do that long-term work yourself. You can choose to run a time-limited program and you can also encourage your participants to keep doing long-term work after they are done with your program. Think of this from the participant's point of view. I'll use myself as an example. When a topic really matters to me, I want to work with someone who is obsessed with that topic for a period of time. I want to be held in a container where I'll get to focus on topic only. I want a curated experience that is designed to help me make a significant change. This happened to me recently. I was a participant last year in Deb Benfield's program: Aging With Vitality And Body Liberation. As a 52 year old who has a body, I loved the idea of putting myself in Deb's hands to go through a big transformative experience over 8 weeks. I wanted to deprogram myself from ageism and step further into body liberation. I know Deb is an expert in both of these areas, and is one of the ONLY people who is really a badass in both areas. In the venn diagram of body liberation and pro-aging, you find Deb and few others in that intersection. she was a grad of my programs, so I know her work well and I trust her. In signing up for Deb's program, I wanted a focused experience to bring about some big changes in perspective and to jump start a process to serve me for as long as I'm lucky enough to keep on aging. I had already done some learning about pro-aging. I'd done years and years of work around body liberation. And within the first session interacting with Deb and the small group, I had some insights that shifted my trajectory permanently. I got to focus on this one topic with Deb so those insights and shifts kept coming. Could I have gone into individual long-term work instead for the same result? Not really. I wouldn't have had the curated experience Deb was able to provide. In long-term work, I would have been busy integrating all the other areas of my life as a parent, partner, business owner, friend, and person healing from childhood trauma. I benefited from the container being ALL about change within this one topic. Now I can take those insights and all the transformation that happened over those 8 weeks and integrate them long term. You better bet that even though the 8 weeks are over, from time to time whenever anything comes up around aging, health, food, or bodies, I say “well Deb Benfield says…” Now I'll share a few more examples of programs that folks in the most recent cohort of CYP have created. All of these are designed to bring about big changes in a particular area over a short period of time. All of them are on topics that are profoundly important to the creator of the program as well as the participants who will enroll. All of these are delivered live by the the creator. Aliza Septimus created an Anxiety Relief Program to help people manage worrying thoughts, calm their bodies, and confidently face things they tend to avoid. Alana Jaeck created Not Just A Pet, a program to help people navigate the loss, or the impending loss of a pet and find their own unique way through the grief. Salina Bambic created a program to help young adults struggling with social anxiety to build confidence so they can form relationships. Ali Schaffer created Wandering In Spain, a retreat for women who are ready to experience transformation through exploration and engagement with nature. Emily Germain created Connected Relationships, a program for busy, motivated couples who are struggling with disconnection. I'll be sharing more examples in future episodes because I LOVE to brag on what our grads have created AND because many of you tell me you crave examples so that you can imagine what's possible. Now after hearing all of this, do you still find yourself wondering whether it's OK to just be a change catalyst? Do you still question whether it's enough to take people through a valuable and time-limited process and then let them turn to other long-term support? Maybe there's some part of you that believes you that you've got to suffer in order to be enough. Maybe there's a part of you that withholds permission to work in the way you will find most joyful and sustainable. If that resonates, I would encourage you to sit with that belief and see if your wisest self agrees. My bet is no. Remember, this week is the time to enroll in CYP to get early access to the curriculum all summer AND a bonus training to help you fill your program. Go to https://rebeltherapist.me/create. I can't wait to support you. Show notes at https://rebeltherapist.me/podcast/227

Speaker Dr Anirban Majumdar: consultant Paediatric Neurologist Blurb Join GP Ruth Bowen exploring the challenging topic of chronic headaches with consultant Paediatric Neurologist Dr Anirban Majumdar. We discuss management of migraines and tension headaches including alternative medicines and supplements, the often challenging overlap between headache phenotypes in CYP, red flags and indications for referral. Resources Headsmart (https://www.mybrainfirst.org/) Migraine trust (https://migrainetrust.org/) Bristol Children's Hospital: Paediatric headache for Primary Care (https://uhbw.mystaffapp.org/diliboards/46/diliboard_contents/307/document_view.pdf) British Paediatric Neurology Association: CHaT (Children's Headache Training) (https://courses.bpna.org.uk/index.php?page=childrens-headache-training)

On ne serait pas le CCS si on avait pas une bonne dose d'autodérision ! Dans cet épisode, nous revenons sur la mock draft publiée par Cyprien sur notre site. En particulier, quels choix sont les plus discutables, et nécessitent un différent point de vue ? Une fois les 32 choix analysés, Hugo et Cyp discutent de la position de LB à la draft. Pourquoi aucun backer ne sera choisi au 1er tour, et qu'est-ce qui rend cette position si difficile à prédire ? Bonne écoute !

Speaker  Helen Tapson -South Gloucestershire Public Health Consultant. Lead for health inequalities in CYP. "We are all in the same storm but we are not all in the same boat".  What local and national projects are striving to tackle health inequalities in Children and Young People? What part do we play in Primary Care?  Play on to find out more as South Gloucestershire Public Health consultant Helen Tapson guides us through the challenging topic of CYP health inequalities: highlighting exciting current national and local projects  and using cases to explore practical tips and resources to empower us in Primary Care. Resources South Gloucestershire Director of Public Health Report: Giving Children the Best Start in Life One stop shop (South Gloucestershire) Virtual hub for financial support (North Somerset) Citizens advice (Bristol, South Gloucestershire, North Somerset) Cost of living advice (South Gloucestershire) Cost of living advice (North Somerset) Cost of living support (Bristol) Healthy start vouchers NHS stop smoking app The Haven (BNSSG)

If you fear bothering people with your marketing, this is for you. I recently got the worst email I've opened in over a year. I'm gonna share the actual email with you and I'm gonna share my internal reactions and the decisions I made after. In the context of life, this email is really NOT that bad at all. No trigger warning necessary. I'm sharing this because I know many of you are really afraid of getting an email like this. I'm hoping hearing about my experience will help you feel less afraid of getting an email like this. I'm hoping that you feeling less afraid will help you make aligned decisions. I'll explain all of that in a moment. The email I'll share was a response to one of my sales emails promoting Create Your Program, the high touch program I run 3 times a year. Here's what the email said: “Way too many emails with not much info. Blocking your email and please remove me from your waitlist. Feels like clickbait.” I said “ouch!” My partner looked over my shoulder and said “that's not nice!” I had a moment of panic. I thought: Am I a fraudster? Am I a villian? Am I a jerk who never provides value? AND…Does this person hate me? And then paused and I said to my partner: “No it's OK. She's right to tell me. She's annoyed.” Now I did feel a little peeved with the email sender. I thought: “She could have just unsubscribed. There's a link in every single email to unsubscribe! Why didn't she just unsubscribe? Why be like that?” And I wished I could write back to her and explain about unsubscribing and also say I'm sorry you didn't get value…and maybe you should check out this or that free resource I provide. But I couldn't write her back because she told me not to contact her. But you know what? She might not know that unsubscribing works. She's totally within her rights to tell me about her experience and to set a digital boundary. She was clear. She did not call me names or behave abusively. She let me know that she's withdrawn her consent to be emailed. I very much WANT people to be able to withdraw their consent. So as she asked, I went into my email platform and deleted her from it. Then while I was there I looked into what emails I had sent her, so I could better understand her experience. She had signed up for a free workshop through an instagram ad that I run. Then she'd gotten follow up emails reminding her to watch that free workshop, and then some sales emails about my program. It's likely that she didn't actually watch the workshop…which is totally understandable. I've signed up for a free workshop or class and then not hit play on it. She also signed up for the waitlist for Create Your Program. She received the maximum amount of emails someone could ever get from me, about 2 a day for a handful of days. That's because she signed up for my free workshop and then my waitlist, all during a launch of my program, I took a step back and considered…is there anything I want to change about this email flow going forward? In this case, there's not much I wanted to change. I want people who are new to my list to have a chance to jump on the wait list for CYP, which functions as an interest list. Often people find me right when they're looking for a program like mine, and it's important that they CAN sign up right away if that's what they want. I only run CYP 3 times a year right now, so I don't want people to have to wait months to have a chance to jump in. I did make one change to my email flow. I already have an opt OUT email that I send to my list when I'm launching. It basically says: “I'm gonna be promoting my program for a couple of weeks. If you want to stay on my list but you don't want to hear about CYP this round, click here. I'll be quiet for a couple weeks.” I learned this opt-out approach from Kelly Diels, and I always hat tip to her in that email. Here's the change: I added a quick opt-out option in just about every sales email. Now if someone on my list opens ANY sales email before the final day of enrollment, they'll have a chance to opt out of receiving more sales emails in that round. This change took about 10 minutes. Done! I feel pretty great about how that went. When I get criticized, I'm tempted to either collapse into shame OR get mad at the person who criticized me. I felt really good noticing that I didn't do either in this situation. I felt twinges of shame and anger, and then I quickly found a more grounded spot. On the shame side I felt: “Hmmmm. this feels upsetting. But also, I know I'm a good person who's striving to do good work. I don't need to collapse into shame.” On the anger side I felt: “I'm irritated at the person who sent the email. BUT also I know she's standing up for herself as best she can and I KNOW that's exactly what people should do. So I don't really need to be mad.” When I teach people about email marketing and guide them to create a practice of emailing their list regularly, they often tell me they're terrified of getting a response like the one I got. Here's the thing: If you email your list, you might get an email like this. But probably not very often. This is the worst email I had gotten in several years. The people I work with and the people who listen to my podcast and read my emails are here to do important work. They're NOT just here to make money. They want to make good money AND they are invested in creating meaningful work that helps people. The people I work with are critical of any kind of tactics that are manipulative. The people who want to connect with Rebel Therapist LOVE consent. So when people like you email your lists, you're probably doing so thoughtfully. The good news is that when you send emails, you'll probably enjoy a LOT of feedback telling you that your work is helpful. When our team member Taitlyn saw the email, she said “this is the FIRST time in the year I've worked here that I've ever seen an email like that.” What a good perspective. I also noticed that on that same DAY, I got an email thanking me for the valuable free content and naming a specific takeaway they got from it. If you're increasing how much you're communicating with your email list, or you are getting more frequent or more bold with your messaging, and you're fearing some kind of push back…I'm here to tell you it's probably gonna be OK. You're going to be able to consider the feedback, take useful stuff from it, leave the rest, and keep doing your important work. Before I close this topic, I need to tell you where this kind of thinking doesn't apply: I have gotten some really mean and abusive comments on social media. Like someone recently sharing that I am hideous. That feels bad of course, but that kind of comment is so clearly NOT something to let in. It's coming from a person who is trying to harm a stranger by insulting that stranger's appearance. I inherently don't believe that's a good thing to be doing. When people are dehumanizing in their communication with you, I DON'T suggest you consider their feedback. Fuck that. That's not feedback. Want to get help from me to create your signature program? Get on the interest list for Create Your Program. You'll be notified first when we open early access registration. In CYP I work with you and a small group of ethical therapists and healers to create signature programs and start working and making money in new ways. —> Get on the list. ( https://rebeltherapist.me/create) Yes, that's the very interest list this person requested being removed from. You can easily unsubscribe at any time. Show Notes at: https://rebeltherapist.me/podcast/222

Speaker: Dr Dinesh Giri, consultant Paediatric Endocrinologist (Bristol Children's Hospital)   With rates of obesity in Children and Young people on the rise, consultant Paediatric Endocrinologist Dr Dinesh Giri gives tips on approaching this tricky subject, what we can do in Primary Care to support and appropriately manage these children and onward referral, including the new government commissioning of severe obesity in CYP clinics.   Resources NHS: fussy eaters  BeeZees bodies: top tips to tackle fussy eating Change4life (renamed 'healthier families')  Live well: advice for parents of overweight children  Healthy start (money for healthy food for 0-4s with a carer on benefits) Health Education England Childhood Obesity elearning

Speakers: Dr Anthony Crabb: Associate Clinical Director for CAMHS in Devon and founder of Held Health Limited, a private healthcare provider of assessment and intervention for CYP with neurodiversity or mental health needs. In this episode Dr Anthony Crabb explores common Primary Care presentations of CYP non-school attendance. He shares knowledge and experience helping families navigate school support, community resources and thresholds for CAMHS input.    Episode resources www.nhs.uk: ADHD  www.nhs.uk: Autism  ADHD UK  National Autistic Society  The Autism Education Trust  Ambitious About Autism  ADHD foundation  Papyrus  Great Ormond Street: ADHD  Great Ormond Street:  Autistic Spectrum Disorder  Bristol Autism Support  Bristol syndiass  Bristol.gov.uk: EHCPs  Bristol.gov.uk: parenting courses  Addressing Education and Health Inequality: Perspectives from the North: 

On this episode of the Real Life Pharmacology podcast, I take a dive into the most common mechanisms of drug interactions. Below I list some of the common drug interactions seen in practice and how they work! Opposing Effects Many drugs will work on various receptors throughout the body. To use as an educational point, there is no better example to point to than the beta receptor. Beta-blockers are frequently used in clinical practice for their ability to lower blood pressure and slow the heart rate. Both of these beneficial actions are primarily achieved by blocking the effects of beta-1 receptors. Some beta-blockers have action on alternative beta receptors. Propranolol is one such beta-blocker that is classified as a non-selective beta-blockers. This means that in addition to the positive effects on beta-1 receptors, it can also have blocking effects on beta-2 receptors. The blockade of the beta-2 receptor by propranolol can also be life-changing. It can directly oppose beta-2 agonists like albuterol from having their beneficial effects of opening up the airway. Enzyme Inhibition Medication metabolism is arguably the largest and most clinically significant source for drug interactions. Medications that are primarily metabolized by enzymes in the liver can be greatly affected if we affect how those enzymes work. CYP3A4 is one of the most well studied and well-known enzymes that can impact hundreds to maybe even thousands of drugs. Apixaban is an oral anticoagulant that is broken down at least in part by CYP3A4. By using a CYP3A4 inhibitor like erythromycin, there is the potential to raise concentrations of apixaban. This could lead to a higher risk of bleeding. Enzyme Induction Carbamazepine is a drug that you must know. This drug is a potent enzyme inducer. This differs significantly from an enzyme inhibitor and will have the exact opposite clinical effect. Drugs that are inactivated by liver enzymes will be inactivated more quickly in a patient taking an enzyme inducer. Going back to our prior apixaban example above, carbamazepine can induce CYP3A4 and facilitate a more efficient and swifter breakdown of the drug. Bleeding will be less likely. The risk for treatment failure, usually in the form of a blot clot, will be more likely.  Here's more information from the past on carbamazepine. Alteration in Absorption Binding interactions can be consequential and are one of the most common types of drug interactions. Many medications have the potential to bind one another in the gut. This can lead to lower concentrations of a specific medication. Calcium and iron are two of the most common examples of medications that can bind other drugs. Alteration in Protein Binding By remembering that unbound drug is an active drug, you should appreciate the risk for protein binding alterations. A significant number of medications can bind proteins in the bloodstream. As this occurs, that drug is not freely available to create physiologic effects. When another medication is added that can also bind these proteins, this can displace other medications and increase the quantity of free drug in the bloodstream. This essentially allows for enhanced physiologic effects. Warfarin is a medication that is highly protein-bound. When another drug is added that can kick warfarin off of those protein binding sites, it can free up warfarin which will increase the likelihood of elevating the patient's INR and increase their bleed risk. Alteration in Renal Elimination Some drugs can alter the way other medications are eliminated through the kidney. Chlorthalidone, like all thiazide diuretics, has the potential to block the excretion of lithium from the kidney. This can lead to lithium toxicity. This type of interaction, while significant, is much less common than drug interactions involve the liver and CYP enzyme pathways.   Effects on Transporters One of the last types of drug interactions is the effe...

As this episode goes live, registration for Create Your Program is open. This is my process to help you create and launch your signature program beyond private practice. If you'd like to start growing another part of your business and make money in a new way, this is the best time to jump into Create Your Program. If you register by Sunday, January 7th, you're going to get lifetime access to a bonus training that has helped grads of CYP to fill their programs. Go to https://rebeltherapist.me/create now to register. I can't wait to see you inside. Today I want to talk about a few really important things that set apart the people who launch programs and succeed from those who wish they had. Here are 3 things people who succeed with their programs are WILLING to do. 1: Be willing to work through discomfort in your marketing. My last guest, Samantha Fox, is great at this. Just like most people who sign up to work with me, Samantha was really nervous about getting more visible and sharing her work with large audiences. Her program is called Unbox Your Sexuality. She helps women all over the world who are realizing they are not as straight as they thought they were. She had to work through her discomfort with being known as a queer thought leader. A few years later, she's so glad she did! She's constantly creating content, including videos, and sharing it with people all over the world. She's guested on about 20 podcasts and gotten comfortable using her voice in that way. She gets to hear from people she's never met about how much her work has changed their lives. So even though she is an introvert and she used to be afraid of visibility, she's now a very public leader who feels abundant love and energy for the people who find her from all over the planet. 2: Be willing to talk about your program with a lot of enthusiasm, and ask people to help you share it. Thing is something that the prior guest, Sonya Brewer, knows how to do! This one sounds obvious, but asking for help is NOT natural or easy for many folks who sign up to work with me. Sonya said that she shared the news about her program, badass boundaries for trauma survivors, with everyone she knows. She asked people: “Who do you have for me?” Sonya was able to do this because she knows her program is excellent. She sees the transformations her participants are able to make, and so she's willing to spread the word. Many people start to shrink or hide or even apologize when it's time to sell their programs. Even if this doesn't come easily to you, I know that you CAN learn to ask for referrals with enthusiasm! I used to shrink when it was time to talk about my work, and now I ask for referrals with ease. I no longer feel like hiding how awesome I know Create Your Program is. I've iterated it over 28 times. I've worked over 200 therapists through it. I've worked with a curriculum designer. We've got the best expert guest teachers who come in and teach particular vital things. CYP has grads like Sonya and Samantha and so many others who have created SO much value. Now when I talk about Create Your Program, I exude a lot of enthusiasm. I also don't care any longer if some folks don't like me because of my confidence. For every person who feels annoyed at my confidence, there are a few people who are encouraged to be a bit more confident themselves. So follow Sonya's lead and shout your program from the rooftops.

Food is essential for life. However, so much of our food is contaminated, whether it be from BPA in food packaging, heavy metals in spices, parabens as preservatives, and more. ⁠ ⁠ One of the worst offenders is glyphosate, a common herbicide found in #RoundUp. A study on rats found that glyphosate reduced levels of the CYP enzyme, which is essential for our liver to detox. This could potentially cause health problems.⁠ ⁠ Why is glyphosate used? How do we limit our exposures? What can we do as citizens to prevent the use of glyphosate?⁠ ⁠ We discussed all of this and more on IG Live with J Gulinello MS, CNSc, FNTP. J Gulinello is a Clinical Nutritionist/Functional Nutritional Therapy Practitioner and founder of @perpetualhealthco.⁠ Learn more about J's services: https://linktr.ee/perpetualhealthco Get tested for BPA, phthalates, parabens, and other hormone-disrupting chemicals with Million Marker's Detect & Detox Test Kit: https://www.millionmarker.com/

On pourrait en parler toute l'année, mais c'est cette semaine qu'on a décidé de s'y coller. On continue de le répéter, il y a trop de receveurs en NFL pour n'en garder que 10, et il est très cruel de laisser autant d'excellents joueurs sur la touche. Mais voilà, il faut bien poser les bases du débat : qui sont les 10 meilleurs à ce poste si important en NFL ? Hugo et Cyp vous donnent leur avis.

Cynata Therapeutics Ltd (ASX:CYP) CEO Dr Kilian Kelly speaks with Proactive soon after announcing the company has initiated the first site in the USA in its Phase 2 clinical trial of CYP-001, in patients with High-Risk acute Graft versus Host Disease (HR-aGvHD). The trial opened for recruitment in Australia in August 2023. Cynata Therapeutics is an Australian clinical-stage stem cell and regenerative medicine company focused on the development of therapies based on Cymerus™ - a proprietary therapeutic stem cell platform technology. #ProactiveInvestors #CynataTherapeutics #ASX #biotech #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

In this episode, I discuss oxymorphone pharmacology, adverse effects, drug interactions, and more! Oxymorphone is approximately 3 times more potent than morphine. I break down some common opioid comparisons in this episode. Oxymorphone avoids many of the CYP interactions. I discuss some of the common interactions in this episode. I discuss histamine release in relation to opioids and oxymorphone and specifically how this may impact our patients.

Ruth is the Resilience Coordinator at Manchester Mind. She designs and delivers courses and workshops to help improve people's mental health and improve their emotional resilience. Specialising in stress management, well-being at work, and confidence building. Manchester Mind is an independent local mental health charity which delivers services to young people and adults. Offering a range of services including:- CYP, our young person's service for 15-25 year-olds.- Advice - free and impartial advice on welfare benefits, housing and debt to people with mental health needs living in Manchester.- Manchester Engagement Team - Manchester Mind support Manchester Mental Health and Social Care Trust in the delivery of Assertive Outreach.- Community and Workplace training - free mental health training for residents of Manchester, as well as a range of open-access courses and short courses on mental health and wellbeing for employers in Manchester.- Food for All - addressing some of the issues around food poverty for people with mental health problemsConnect with Ruth here - https://www.linkedin.com/in/ruth-rosselson-07970/Find more details on Manchester Mind here - https://www.manchestermind.org/In this episode, the key points covered are: How do we spot someone heading to burn outhow can we become more mindfulHow can we ensure we all feel supported in our well-beingHow can we support those going through menopauseHow can we support our local mind-------------The Recruiter's Recruitment Podcast is proudly sponsored by Paiger and partners to Needi and Inclusion Crowd.Our Sponsor: Paiger - Making Recruiters Smarter and Faster. Paiger helps recruiters build personal brands, identify new business opportunities, attract candidates, and have better conversations.Find out more details on Paiger here - https://paiger.co/?utm_source=podcast&utm_medium=sponsor&utm_campaign=recruiters-recruiterOur Partners: Needi is a concierge gift-matching service using psychology and AI, to pinpoint the perfect gifts and experiences for your recipient, from the best, local independent businesses. Their team of expert gift finders, save companies time and money, with their complimentary corporate gifting service . Find out more here -https://needi.co.uk/Inclusion Crowd works with organisations to create a credible and authentic DEI programme, they help clients attract & retain talent - as well as improve culture & engagement. Their vision is to make organisations reflective of the societies in which they operate. Find out more here https://inclusioncrowd.biz/Watch the episode here - https://youtu.be/3cEPJWuVkPk****SPECIAL ANNOUNCEMENT****We are so pleased to announce that we are hosting our first LIVE event on November 23rd in Manchester! Every single penny from ticket sales will be going to charity and our nominated charities are: Lifeshare Manchester Mind For more details on the event and to purchase your ticket follow the link - https://www.eventbrite.co.uk/e/the-recruiters-recruitment-podcast-live-event-manchester-tickets-720877121877?aff=oddtdtcreatorThis podcast uses the following third-party services for analysis: Chartable - https://chartable.com/privacy

Deuxième épisode de la saison 2 du stud avec : Cyp'FPV On y parlera de son parcours et de bando ! La chaine de Cyp : https://www.youtube.com/user/airsoft972 Sa page facebook : https://www.facebook.com/CypFpv Son insta : https://www.instagram.com/cyp_fpv/ La saison 2 du stud est réalisé avec le soutien de StudioSPORT : https://bit.ly/3vRmjL3

Wanneer is zo'n screening van de CYP enzymen van je lever nou interessant en relevant voor je? Ilonka stelde me deze vraag naar aanleiding van een eerdere podcast die ze van me hoorde. In deze aflevering deel ik met je wanneer en waarom het goed kan zijn om zo'n screening te laten maken. Tipje van de sluier: histamine en het niet (lijken te) werken van supplementen komen aan bod!

This is Garrison Hardie with your CrossPolitic Daily News Brief for Friday, March 17th, 2023. Happy Friday everyone! New Saint Andrews: Today’s culture shifts like sand, but New Saint Andrews College is established on Christ, the immovable rock. The college is a premier institution that forges evangelical leaders who don’t fear or hate the world. Guided by God’s word, equipped with the genius of classical liberal arts and God-honoring wisdom, with a faculty dedicated to academic rigor and to God’s kingdom, New Saint Andrews College offers an education that frees people. Logic and language, hard work and joyful courage, old books and godly professors — New Saint Andrews Colleges provides time-tested resources that can equip your student for any vocation. To find out more, visit: nsa.edu https://www.theepochtimes.com/health/american-children-are-dying-at-highest-rate-in-50-years_5124568.html?utm_source=partner&utm_campaign=BonginoReport American Children Are Dying at Highest Rate in 50 Years Mortality rates among American children and adolescents rose by almost 20 percent in just two years, with non-COVID injuries being a top reason for increased deaths. Between 2019 and 2020, all-cause mortality rates for Americans in the age group of 1 to 19 years jumped by 10.7 percent, according to data collected and published by JAMA Network from the American Medical Association. This was followed by an 8.3 percent spike between 2020 and 2021. The total mortality rate in the two years between 2019 and 2021 was 19 percent—the biggest increase in at least 50 years. “These increases, the largest in decades, followed a period of great progress in reducing pediatric mortality rates,” the editorial stated. “This reversal in the pediatric mortality trajectory was caused not by COVID-19, but by injuries,” the editorial stated. “In 2020, the COVID-19 mortality rate at ages 1 to 19 years was 0.24 deaths per 100 000, but the absolute increase in injury deaths alone was nearly 12 times higher (2.80 deaths per 100 000).” Between 2019 and 2020, injury mortality rose by 22.6 percent among those between the ages of 10 and 19, with homicides rising by 39.1 percent and drug overdose deaths jumping by 113.5 percent. Among children aged 1 to 9 years, injuries accounted for 63.7 percent of the increase in all-cause mortality in 2021. “We’ve now reached a tipping point where the number of injury-related deaths is so high that it is offsetting many of the gains we’ve made in treating other diseases,” said Elizabeth Wolf, an author of the editorial and an assistant professor in the department of pediatrics at the Virginia Commonwealth University’s School of Medicine. The editorial points out that the increase in injury deaths predates the pandemic. For instance, suicides among individuals between 10 and 19 years of age began to rise in 2007, with homicide rates starting to increase in 2013. Between 2007 and 2019, mortality rates for suicide rose by 69.5 percent. Between 2013 and 2019, homicide rates increased by 32.7 percent. The editorial blamed the increase in suicide and homicide rates on a “deepening” mental health crisis and access to firearms. Despite the fear created by the pandemic, the share of COVID-19 in deaths among children and young people (CYP) was lower when compared to other causes, according to a Jan. 30 study published in JAMA Network. The study identified 821 deaths among CYP aged 0 to 19 years between August 1, 2021, and July 31, 2022, in the United States and compared it with other causes of death in 2019 prior to the pandemic. COVID-19 was ranked eighth among all causes of death within this demographic, accounting for 2 percent of all causes of death. According to data from the National Center for Health Statistics, unintentional injuries were the leading cause of death among children in 2020, accounting for 12.5 percent of deaths below the age of 12 and 31.4 percent of deaths among adolescents aged 12-17. COVID-19 accounted for 0.3 percent of deaths in children under the age of 12 and 0.8 percent of deaths among those aged 12-17. Mental health among children and adolescents worsened during the pandemic per a paper published in The Lancet Psychiatry that analyzed emergency department visits. The analysis found a 22 percent jump in youth visits for suicide attempts when comparing the period prior to the pandemic to the pandemic period until July 2021. This surge in suicide visits happened even though there was a 32 percent reduction in pediatric emergency department visits for health-related reasons during the pandemic. In addition, there was also an 8 percent increase in visits for suicidal ideation—referring to individuals who entertain suicidal thoughts. A study on the National Poison Data System found that suspected suicide attempts through self-poisoning among children rose by 26.7 percent between 2015 and 2020. Speaking of children… https://hotair.com/david-strom/2023/03/15/fda-pushing-vaccine-boosters-for-infants-based-upon-trials-in-just-24-children-n537177 FDA pushing vaccine boosters for infants based upon trials in just 24 children The FDA has approved the use of a new bivalent COVID-19 booster for children 6 months old to 4 years old based upon trials that included almost no children. 24 participants for the 6-month-23-month cohort, and 36 for the 2 years through 4 years old cohort. 60 children in all. There are tens of millions of children in these age cohorts, and while this sort of trial is better than one where only 9 mice are given the jab, it strikes me as bizarre that the FDA is pushing this out the door and recommending that all children in America be vaccinated with a jab that has barely been tested. Particularly given that the COVID virus presents almost no threat to any children those ages. European countries have pulled back from recommending or even giving COVID vaccines to people under 50, except in cases where the patient is in a high-risk category. It beggars belief that the United States FDA is still going full steam ahead recommending vaccines that are not actually approved–they are being given under an Emergency Use Authorization, not full approval–to millions of children at little risk for serious disease. Even the FDA admits that there are side effects, because of course there are. There are with everything. Side effects can be justified if the benefits outweigh the downsides, but there really is no evidence that the benefits are there. Alps Precious Metals Group The Word of God in Genesis 2:10-12b teaches this: “…And a river went out of Eden to water the garden; and from thence it was parted, and became into four heads. The name of the first is Pison: that is it which compasseth the whole land of Havilah, where there is gold; And the gold of that land is good…” Gold maintains God’s stamp of approval if used with the wisdom He gives us by His Grace. Since the creation of the Federal Reserve and all of the other Central Planning Banks around the world, tumultuous modern financial markets have been the natural consequence. In the midst of these tempests, such as the one that is upon us now, Gold has maintained an impeccable record of preserving the labor and wealth of individuals, families and institutions. Alps Precious Metals is a U.S.-based company formed for the purpose of re-establishing the essential role of Physical Precious Metals within investment portfolios. Whether as a compliment or replacement for bank/brokerage accounts and/or Retirement accounts, Physical Precious Metals allow the investor to own *the* bedrock asset that has weathered all financial storms. Call James Hunter of Alps at 251-377-2197, and visit our website at www.alpspmg.com to begin the discussion of the trading and Vaulting of Physical Precious Metals. https://townhall.com/tipsheet/spencerbrown/2023/03/16/biden-administration-pursuing-a-taxpayer-funded-bailout-for-moderna-n2620646 The Biden Administration Is Trying to Bail Out Moderna While Americans' eyes and justified outrage are aimed at the Biden administration's "not a bailout" bailout of failed banks, there's an even larger bailout — and potentially a new scandal for Biden — his administration is pursuing. Specifically, the Biden Department of Justice has inserted the federal government — and with it hardworking American taxpayers — into a patent infringement dispute alleging that Moderna stole intellectual property from smaller biotech companies and used it to create and produce its COVID-19 mRNA vaccine that's since been administered more than 250 million times in the U.S. and sent the company's revenue soaring. According to the two small biotech companies alleging patent infringement — called Arbutus and Genevant — Moderna stole their vaccine delivery method that uses lipid nanoparticles (LNPs) to protect vaccine-introduced mRNA in the bloodstream and help ensure it reaches the intended target to become effective. Moderna's response to Arbutus and Genevant has not focused on the companies' claims, but sought to have the case dismissed entirely. Moderna says that, under a World War I-era law found in Section 1498 of U.S. Code, its vaccine development and production is shielded from patent claims because it was under contract to provide the vaccine to the federal government. Moderna maintains its COVID vaccine did not infringe on intellectual property, but said that "dispute is for later." Rather than allowing the case to play out on its own, the Biden administration — via Delaware U.S. Attorney David Weiss — filed a statement of interest in the dispute last month "to relieve Moderna of any liability for patent infringement resulting in performance of the ’-0100 Contract and to transfer to the United States any liability for the manufacture or use of the inventions claimed in the Patents-in-Suit resulting from the authorized and consented acts." The "-0100 Contract" mentioned by the U.S. attorney in its statement of interest is an $8.2 billion contract between Moderna and the Department of Defense coded as "pharmaceutical preparation manufacturing." So, the Biden administration appears to be stepping in and seeking to put hardworking American taxpayers on the hook for what could be potentially billions of dollars worth of liability claims caused by Moderna's alleged theft of intellectual property to make its COVID vaccine. Why would the Biden administration, after the federal government has already poured billions of dollars into Moderna for its COVID vaccine, now seek to bail them out for, potentially, billions more? And why did the Biden DOJ wait until February of 2023 to file a statement of interest when the case against Moderna has been in motion since early 2022? And that's where another twist complicates the Biden DOJ's intervention and raises more questions about how the decision to intervene was made. The U.S. attorney filed the statement of interest on behalf of the Biden DOJ on February 14 and, one day later on February 15, Moderna announced its "commitment to patient access in the United States." The company's announcement states that "Moderna remains committed to ensuring that people in the United States will have access to our COVID-19 vaccines regardless of ability to pay" and Americans who are uninsured or underinsured will still be able to get Moderna's COVID vaccines at pharmacies and doctors' offices at "no cost" to them. In 2019, the company's revenue was $60 million. It increased to $803 million in 2020, then surged to more than $18 billion in 2021. It seems as though the federal government has done enough to help Moderna by now, and yet the U.S. government intervened on Moderna's behalf in the patent infringement case to say American taxpayers should assume liability for claims stemming from the company's alleged intellectual property theft. So far, the judge hearing claims against Moderna has not sided with the company's — or the Biden DOJ's — claims that the federal government (again, read: taxpayers) should be held liable instead, and has ruled against motions to dismiss the case outright. Next week, Moderna's CEO Stéphane Bancel will testify before the Senate Health, Education, Labor and Pensions (HELP) Committee. That hearing, led by HELP Chairman Bernie Sanders (I-VT), is titled "Taxpayers Paid Billions For It: So Why Would Moderna Consider Quadrupling the Price of the COVID Vaccine?" And finally… https://www.washingtonexaminer.com/restoring-america/community-family/california-pushes-360k-person-reparations-despite-major-deficit California pushes for $360,000 per person in reparations despite major deficit The state-endorsed California Reparations Task Force is pushing to give every black resident $360,000 in reparations despite a major budget deficit. In 2020, the United States Census Bureau recorded approximately 2.251 million black people residing in California, of whom 1.8 million had at least one ancestor who was a slave, Fox News reported , making the total reparations cost around $640 billion. It is unknown where the state will come up with the funds, however, as Gov. Gavin Newsom (D-CA) reported that California is facing a budget deficit of $22.5 billion for this coming fiscal year. Chas Alamo, the state's Legislative Analyst's Office's principal fiscal and policy analyst, appeared at the Reparation Task Force's second in-person meeting, in which he proposed further steps that could be taken to fulfill the reparations plan. He proposed several different paths the task force could take to make reparations state law, including the creation of a new agency that would oversee the dispensation of reparations. "The creation of a new agency would be initiated through the governor's executive branch and reorganization process, but other options exist," Alamo said, California Black Media reported. "Regardless of the path, to initiate a new agency or enact any other recommendation that makes changes to state law, fundamentally both houses from the state legislature would have to approve the action and the governor will have to sign it." The task force is due to submit a final report and its accompanying recommendations by July 1. The state legislature, which created the commission amid the fallout from George Floyd's death in 2020, will then vote on the proposal, at which point it will be sent to Newsom to sign. So far, neither the panel nor any government agency has suggested how the reparations will be paid for. Meanwhile, a separate, city-appointed reparations task force in San Francisco recommended giving $5 million in reparations to every black resident, which would total nearly $225 billion.

This is Garrison Hardie with your CrossPolitic Daily News Brief for Friday, March 17th, 2023. Happy Friday everyone! New Saint Andrews: Today’s culture shifts like sand, but New Saint Andrews College is established on Christ, the immovable rock. The college is a premier institution that forges evangelical leaders who don’t fear or hate the world. Guided by God’s word, equipped with the genius of classical liberal arts and God-honoring wisdom, with a faculty dedicated to academic rigor and to God’s kingdom, New Saint Andrews College offers an education that frees people. Logic and language, hard work and joyful courage, old books and godly professors — New Saint Andrews Colleges provides time-tested resources that can equip your student for any vocation. To find out more, visit: nsa.edu https://www.theepochtimes.com/health/american-children-are-dying-at-highest-rate-in-50-years_5124568.html?utm_source=partner&utm_campaign=BonginoReport American Children Are Dying at Highest Rate in 50 Years Mortality rates among American children and adolescents rose by almost 20 percent in just two years, with non-COVID injuries being a top reason for increased deaths. Between 2019 and 2020, all-cause mortality rates for Americans in the age group of 1 to 19 years jumped by 10.7 percent, according to data collected and published by JAMA Network from the American Medical Association. This was followed by an 8.3 percent spike between 2020 and 2021. The total mortality rate in the two years between 2019 and 2021 was 19 percent—the biggest increase in at least 50 years. “These increases, the largest in decades, followed a period of great progress in reducing pediatric mortality rates,” the editorial stated. “This reversal in the pediatric mortality trajectory was caused not by COVID-19, but by injuries,” the editorial stated. “In 2020, the COVID-19 mortality rate at ages 1 to 19 years was 0.24 deaths per 100 000, but the absolute increase in injury deaths alone was nearly 12 times higher (2.80 deaths per 100 000).” Between 2019 and 2020, injury mortality rose by 22.6 percent among those between the ages of 10 and 19, with homicides rising by 39.1 percent and drug overdose deaths jumping by 113.5 percent. Among children aged 1 to 9 years, injuries accounted for 63.7 percent of the increase in all-cause mortality in 2021. “We’ve now reached a tipping point where the number of injury-related deaths is so high that it is offsetting many of the gains we’ve made in treating other diseases,” said Elizabeth Wolf, an author of the editorial and an assistant professor in the department of pediatrics at the Virginia Commonwealth University’s School of Medicine. The editorial points out that the increase in injury deaths predates the pandemic. For instance, suicides among individuals between 10 and 19 years of age began to rise in 2007, with homicide rates starting to increase in 2013. Between 2007 and 2019, mortality rates for suicide rose by 69.5 percent. Between 2013 and 2019, homicide rates increased by 32.7 percent. The editorial blamed the increase in suicide and homicide rates on a “deepening” mental health crisis and access to firearms. Despite the fear created by the pandemic, the share of COVID-19 in deaths among children and young people (CYP) was lower when compared to other causes, according to a Jan. 30 study published in JAMA Network. The study identified 821 deaths among CYP aged 0 to 19 years between August 1, 2021, and July 31, 2022, in the United States and compared it with other causes of death in 2019 prior to the pandemic. COVID-19 was ranked eighth among all causes of death within this demographic, accounting for 2 percent of all causes of death. According to data from the National Center for Health Statistics, unintentional injuries were the leading cause of death among children in 2020, accounting for 12.5 percent of deaths below the age of 12 and 31.4 percent of deaths among adolescents aged 12-17. COVID-19 accounted for 0.3 percent of deaths in children under the age of 12 and 0.8 percent of deaths among those aged 12-17. Mental health among children and adolescents worsened during the pandemic per a paper published in The Lancet Psychiatry that analyzed emergency department visits. The analysis found a 22 percent jump in youth visits for suicide attempts when comparing the period prior to the pandemic to the pandemic period until July 2021. This surge in suicide visits happened even though there was a 32 percent reduction in pediatric emergency department visits for health-related reasons during the pandemic. In addition, there was also an 8 percent increase in visits for suicidal ideation—referring to individuals who entertain suicidal thoughts. A study on the National Poison Data System found that suspected suicide attempts through self-poisoning among children rose by 26.7 percent between 2015 and 2020. Speaking of children… https://hotair.com/david-strom/2023/03/15/fda-pushing-vaccine-boosters-for-infants-based-upon-trials-in-just-24-children-n537177 FDA pushing vaccine boosters for infants based upon trials in just 24 children The FDA has approved the use of a new bivalent COVID-19 booster for children 6 months old to 4 years old based upon trials that included almost no children. 24 participants for the 6-month-23-month cohort, and 36 for the 2 years through 4 years old cohort. 60 children in all. There are tens of millions of children in these age cohorts, and while this sort of trial is better than one where only 9 mice are given the jab, it strikes me as bizarre that the FDA is pushing this out the door and recommending that all children in America be vaccinated with a jab that has barely been tested. Particularly given that the COVID virus presents almost no threat to any children those ages. European countries have pulled back from recommending or even giving COVID vaccines to people under 50, except in cases where the patient is in a high-risk category. It beggars belief that the United States FDA is still going full steam ahead recommending vaccines that are not actually approved–they are being given under an Emergency Use Authorization, not full approval–to millions of children at little risk for serious disease. Even the FDA admits that there are side effects, because of course there are. There are with everything. Side effects can be justified if the benefits outweigh the downsides, but there really is no evidence that the benefits are there. Alps Precious Metals Group The Word of God in Genesis 2:10-12b teaches this: “…And a river went out of Eden to water the garden; and from thence it was parted, and became into four heads. The name of the first is Pison: that is it which compasseth the whole land of Havilah, where there is gold; And the gold of that land is good…” Gold maintains God’s stamp of approval if used with the wisdom He gives us by His Grace. Since the creation of the Federal Reserve and all of the other Central Planning Banks around the world, tumultuous modern financial markets have been the natural consequence. In the midst of these tempests, such as the one that is upon us now, Gold has maintained an impeccable record of preserving the labor and wealth of individuals, families and institutions. Alps Precious Metals is a U.S.-based company formed for the purpose of re-establishing the essential role of Physical Precious Metals within investment portfolios. Whether as a compliment or replacement for bank/brokerage accounts and/or Retirement accounts, Physical Precious Metals allow the investor to own *the* bedrock asset that has weathered all financial storms. Call James Hunter of Alps at 251-377-2197, and visit our website at www.alpspmg.com to begin the discussion of the trading and Vaulting of Physical Precious Metals. https://townhall.com/tipsheet/spencerbrown/2023/03/16/biden-administration-pursuing-a-taxpayer-funded-bailout-for-moderna-n2620646 The Biden Administration Is Trying to Bail Out Moderna While Americans' eyes and justified outrage are aimed at the Biden administration's "not a bailout" bailout of failed banks, there's an even larger bailout — and potentially a new scandal for Biden — his administration is pursuing. Specifically, the Biden Department of Justice has inserted the federal government — and with it hardworking American taxpayers — into a patent infringement dispute alleging that Moderna stole intellectual property from smaller biotech companies and used it to create and produce its COVID-19 mRNA vaccine that's since been administered more than 250 million times in the U.S. and sent the company's revenue soaring. According to the two small biotech companies alleging patent infringement — called Arbutus and Genevant — Moderna stole their vaccine delivery method that uses lipid nanoparticles (LNPs) to protect vaccine-introduced mRNA in the bloodstream and help ensure it reaches the intended target to become effective. Moderna's response to Arbutus and Genevant has not focused on the companies' claims, but sought to have the case dismissed entirely. Moderna says that, under a World War I-era law found in Section 1498 of U.S. Code, its vaccine development and production is shielded from patent claims because it was under contract to provide the vaccine to the federal government. Moderna maintains its COVID vaccine did not infringe on intellectual property, but said that "dispute is for later." Rather than allowing the case to play out on its own, the Biden administration — via Delaware U.S. Attorney David Weiss — filed a statement of interest in the dispute last month "to relieve Moderna of any liability for patent infringement resulting in performance of the ’-0100 Contract and to transfer to the United States any liability for the manufacture or use of the inventions claimed in the Patents-in-Suit resulting from the authorized and consented acts." The "-0100 Contract" mentioned by the U.S. attorney in its statement of interest is an $8.2 billion contract between Moderna and the Department of Defense coded as "pharmaceutical preparation manufacturing." So, the Biden administration appears to be stepping in and seeking to put hardworking American taxpayers on the hook for what could be potentially billions of dollars worth of liability claims caused by Moderna's alleged theft of intellectual property to make its COVID vaccine. Why would the Biden administration, after the federal government has already poured billions of dollars into Moderna for its COVID vaccine, now seek to bail them out for, potentially, billions more? And why did the Biden DOJ wait until February of 2023 to file a statement of interest when the case against Moderna has been in motion since early 2022? And that's where another twist complicates the Biden DOJ's intervention and raises more questions about how the decision to intervene was made. The U.S. attorney filed the statement of interest on behalf of the Biden DOJ on February 14 and, one day later on February 15, Moderna announced its "commitment to patient access in the United States." The company's announcement states that "Moderna remains committed to ensuring that people in the United States will have access to our COVID-19 vaccines regardless of ability to pay" and Americans who are uninsured or underinsured will still be able to get Moderna's COVID vaccines at pharmacies and doctors' offices at "no cost" to them. In 2019, the company's revenue was $60 million. It increased to $803 million in 2020, then surged to more than $18 billion in 2021. It seems as though the federal government has done enough to help Moderna by now, and yet the U.S. government intervened on Moderna's behalf in the patent infringement case to say American taxpayers should assume liability for claims stemming from the company's alleged intellectual property theft. So far, the judge hearing claims against Moderna has not sided with the company's — or the Biden DOJ's — claims that the federal government (again, read: taxpayers) should be held liable instead, and has ruled against motions to dismiss the case outright. Next week, Moderna's CEO Stéphane Bancel will testify before the Senate Health, Education, Labor and Pensions (HELP) Committee. That hearing, led by HELP Chairman Bernie Sanders (I-VT), is titled "Taxpayers Paid Billions For It: So Why Would Moderna Consider Quadrupling the Price of the COVID Vaccine?" And finally… https://www.washingtonexaminer.com/restoring-america/community-family/california-pushes-360k-person-reparations-despite-major-deficit California pushes for $360,000 per person in reparations despite major deficit The state-endorsed California Reparations Task Force is pushing to give every black resident $360,000 in reparations despite a major budget deficit. In 2020, the United States Census Bureau recorded approximately 2.251 million black people residing in California, of whom 1.8 million had at least one ancestor who was a slave, Fox News reported , making the total reparations cost around $640 billion. It is unknown where the state will come up with the funds, however, as Gov. Gavin Newsom (D-CA) reported that California is facing a budget deficit of $22.5 billion for this coming fiscal year. Chas Alamo, the state's Legislative Analyst's Office's principal fiscal and policy analyst, appeared at the Reparation Task Force's second in-person meeting, in which he proposed further steps that could be taken to fulfill the reparations plan. He proposed several different paths the task force could take to make reparations state law, including the creation of a new agency that would oversee the dispensation of reparations. "The creation of a new agency would be initiated through the governor's executive branch and reorganization process, but other options exist," Alamo said, California Black Media reported. "Regardless of the path, to initiate a new agency or enact any other recommendation that makes changes to state law, fundamentally both houses from the state legislature would have to approve the action and the governor will have to sign it." The task force is due to submit a final report and its accompanying recommendations by July 1. The state legislature, which created the commission amid the fallout from George Floyd's death in 2020, will then vote on the proposal, at which point it will be sent to Newsom to sign. So far, neither the panel nor any government agency has suggested how the reparations will be paid for. Meanwhile, a separate, city-appointed reparations task force in San Francisco recommended giving $5 million in reparations to every black resident, which would total nearly $225 billion.

On this episode, I discuss the pharmacology, adverse effects, and drug interactions of ramelteon (Rozerem). Ramelteon is primarily only helpful for sleep onset and generally is not that helpful in sleep maintenance. CNS depressant drug interactions will be a common concern to monitor. Opioids, benzodiazepines, and alcohol are common sedatives that can add to the effects of ramelteon. Some of the CYP enzymes break down Ramelteon. I discuss this in greater length in this podcast episode.

I thought this episode was going to be titled “A Little Dose Of Healthy Narcissism.” One of my brilliant past clients pointed out that a little dose of healthy narcissism seems to be necessary in order to grow a program beyond private practice and step into the world of marketing. Their idea was that perhaps you've got to step into a tiny bit of narcissism to have the courage to grow your audience and sell your offer. Disclaimer: We're not talking about narcissism like what we see in Elon Musk or Donald Trump. We're not talking about a diagnosis either. We're really talking about a bit of bold inner confidence. I mentioned this concept to a coach I was working with and she said “That's a great podcast episode!” So I put “A Little Dose Of Healthy Narcissism” in my list of future podcast episodes. And it sat there…and sat there… for a year. Then I realized that a little dose of healthy narcissism isn't really what I focus on or where my clients, friends or colleagues who are making great money with simple businesses are focusing. Even that coach who told me it would be a great episode doesn't run on narcissism or bold confidence. Side note: If you do have a little dose of healthy narcissism going for you, wonderful! Especially if you're queer, you're a person of color, you're a woman, and/or you hold any marginalized identity, your confidence is a beautiful and radical thing. I love it. I just don't believe you've got to cultivate bold confidence before you can make your business fly. You don't need to wait until you feel confident, and you don't need to focus your energy on building your confidence. For those of us raised as girls, confidence can be extra tricky. We've been taught forever NOT to act too confident. Confidence is tricky for MANY of us. So if it isn't about stepping into a little dose of healthy narcissism, what DOES help you feel confident selling your offer? It's about falling in love with and geeking out on your work, and specifically on your signature offer. I've had the best year ever in my business. Again. And it's not because I've cracked the code on being super confident. My confidence goes up and down throughout the day and throughout the seasons. My confidence depends on what's happening with my hormones, what's going on with my kids, maybe even whether something reminds me of high school when I didn't sit in the lunchroom but instead hid in the library. But I've got confidence in my offer. My offer is great at helping therapists create and sell their programs, and I'm getting more and more known for it. I've totally fallen in love with my own offer. I created it for people I care about and listened carefully to, based on what I do best. I've then improved it with every iteration. The program also has amazing guest teachers who do things I can't. I've put my best work and resources into it. CYP is an amazing process and there's nothing else like it for therapists in private practice to create and sell an offer beyond private practice. So every time I get ready to talk about my offer as a podcast guest or on my podcast or I run an open house or update my sales page, I think: “Dang this is an amazing offer!” Putting your best work into your offer is the foundation of having confidence in selling that offer. Sometimes that confidence might look like a bit of narcissism. Like…maybe I seem narcissistic right now.

Rabbi Mayshe Schwartz: Connecting Two Generations Of Rabbis In A Boston NICU"Somebody please get me a Chabad rabbi. The surgery is going to take place in 2 hours. I just need someone to come and pray.” - Jacer Collins"I ran over, dropped everything, and went to Children's Hospital, the 7th floor... She pulled me towards the crib, tiny little crib. You know, what do you say?... The only thing that came out of my mouth was the following; "G-d can do anything. Let's pray for a miracle." - Rabbi Mayshe SchwartzProduced by: Gary Waleik & Shneur Brook for Lubavitch International/Lubavitch.comAvailable on all major podcast platforms - and online at Lubavitch.com/podcastDid you enjoy listening to this episode? Leave us a review and/or email us at Podcast@Lubavitch.com - we truly value your feedback!To inquire about dedicating an episode - please email podcast@lubavitch.com

In Episode 3, we invite Lieutenant Commander Shane Beener from N9 department to discuss job opportunities around CFAY, what the child youth program can do for you, as well as the newly opened teen center.

Drugs n Stuff 159 Dave Crosland & Scott McNally - Navy Seals on Steroids? Persiflage & Steroid QA TIME STAMPS BELOW

People ask me all the time “What should I do now to grow my business?” Often they say: “I heard….is a good idea. Should l do that?” Every online business expert is selling their thing to us. (Including me!) Our friends and colleagues tell us that what they are doing now is THE thing that works. It's confusing to figure out what to invest our time and money in and what to try. What should YOU focus on next? People ask me whether they should: Figure out their visual Branding. Uplevel their Website design. Learn Copywriting skills Learn email marketing skills Dive into Social media strategy Get on Tiktok Buy legal templates Redesign their curriculum Join a high priced mastermind Buy another business course Learn how to run paid ads Start a podcast Start being a guest on podcasts Create a self-led course Hire a virtual assistant or an online business manager Invest in a new tech platform to get organized Create a monthly membership How do you figure out what you should do? I've gotten really clear that before we talk about WHAT you should do, we need to talk WHEN you should do certain things. If you ask me whether you should hire a social media manager or create a monthly membership or take a copywriting course or really anything…my first question will be: Where are you in your business right this minute? I used to be way more agnostic about this. If you worked with me in 2018 you might have heard me say…sure it might not be ideal but…you COULD try a monthly membership as your first thing. I didn't want to take anyone's freedom away. I got clear pretty fast that doing things in the wrong order sets us up to lose money and feel miserable. As you're creating a business beyond private practice, and stepping into the world of online services that are not therapy, you can waste a TON of time and money doing things in the wrong order. Even if those are not the wrong things to do. I sometimes hear very sad stories from people who started with the wrong things. People tell me they invested in 20K coaching programs as one of their first steps in business beyond private practice. Those programs taught them to use complicated funnels including paid ads and webinars. I've talked to other folks who started hiring a team as their first thing. They figured since the marketing felt hard, they'd start by hiring someone to “take over all of their marketing.” Other people got advice that they should grow a huge social media following as their first step. Their businesses were not at the right stage for any of those moves, and their frustration and sadness comes from feeling like they've failed, they've wasted tons of money, and even believing it's their fault. Any of those moves might make sense at the right time. I'm not saying coaching programs should never cost 20k. That's not the takeaway. For some business owners, hiring someone to help you implement your marketing strategy might make sense when you're at a certain stage. And developing a social media following is still part of a sound strategy for some business owners. Here's a small tangent on that one. Growing a huge audience as your first step used to work. That's why people keep teaching it. Tara McMullin, one of my mentors, and my guest in the last episode, wrote a wonderful article titled: You Can't Grow an Audience Like You Used To (and That's Okay) Tara walks us through the history of online marketing and explains why the strategy of growing a huge audience and THEN starting to sell stuff to them worked in the past and is not working any longer. If you're thinking…"but that's what Pat Flynn did! That's what Amy Porterfield did!" you might want to read that article. End of tangent. You've gotta take steps to create and then grow your business in the right order. Just like you have to build a house in the right order. You shouldn't start with the roof. So what ARE the first things to do when you're in stage one of a new business? (Perhaps you've already got a private practice, but we're talking about creating a NEW business beyond private practice. Any new business starts at stage 1.) Stage one has 3 steps. Those 3 steps are to identify a viable niche, create a highly valuable offer for that niche, and sell that offer. Let's go through each of those for a moment. The first step is to identify a viable niche. If you want to hear me talk through the process of choosing your niche, head to my episode titled The Best Niches Beyond Private Practice. Sometimes therapists and healers want to skip or rush through this step. Niche work can feel tedious. It can feel limiting. It can feel…NOT like what you want to do first! And maybe you know you can serve a whole bunch of different niches really well. Maybe in your private practice you haven't niched and you're very successful. Well… creating a signature program and a business beyond private practice with a vague or broad niche is VERY difficult and sets you up to feel discouraged and sad. So go listen to that niching episode to hear examples of viable niches and what makes a great niche. Step two is to create and a pilot or beta offer for that niche. Do this quickly so that you find out whether your idea works and so that you can start making money. Your pilot is going to be highly interactive, and you're going to deliver it 1:1 or to a very small group. You're crafting your pilot for the people in your niche, based on exactly what they need from you and what you're great at delivering. Sometimes therapists want to skip over this step and create a passive online course or start building a monthly membership. Don't start there. Because: That only possibly works when you've got a lot of people aware of your work and in your audience. Even if you have a big audience, every offer should start live and interactive. That's how you're gonna build the best offer. If you pre-record videos for your pilot, you're going to be re-recording them for round 2. You might as well save yourself ALL of those hours. The formats I recommend for a pilot are: Small-group coaching 1:1 coaching Training or consulting package for an organization Workshop Retreat Once you've done those first 2 steps, identifying your niche and crafting your pilot offer, you're ready for the next step. Step 3 is to sell your program. You'll do this through a relational/soft launch. You're going to tell everyone you know that you've created this pilot, and you're going to invite your first participants. A relational launch will include reaching out personally to your colleagues, announcing your offer in communities you belong to, sending personal invites to potential participants, offering discovery calls to people who are considering signing up, and maybe running free interactive events like a Q&A or a free workshop over zoom. If you're not sure whether enough people are aware of your work and ready to make those referrals, you're going to start with a 1:1 offer even if you KNOW you're going to turn it into a group offer soon. A lot of people ask me how long it takes to move through those 3 steps. You can go through them in 8 weeks or you can take up to a year. That length of time depends on: your focus whether you get led away to other opportunities how much time you can dedicate to the process whether you try out some vague niches or wrong-fit pilots whether the tech involved in these steps trips you up your willingness to ask people to spread the word your willingness to invite people to your program your ability to communicate your understanding of your right fit person's situation your ability to communicate the value of your offer There's one more thing you might want to do in stage one. You're probably going to want to start an email list. If there's a good chance you're going to stick with this niche, you'll likely regret not having started an email list. And don't do ANYTHING else until you're through stage one. Don't focus on branding or naming or Tiktok or anything else. Those activities will take you away from your first 3 steps. And you won't get much value from those things until you've done those 3 steps. Any skilled branding expert or web designer or copywriter is going to ask you to tell them about and show them your foundation. Then they can help you amplify it. If you don't have a business, there's nothing to amplify. But what about tech platforms? The only tech/platform things you might need or want are: A simple, DIY, one or 2 page website for describing and selling your offer A simple checkout process so that people can pay you The minimal platforms needed to deliver the program (like zoom) And perhaps you'll want Legal templates An email marketing service so that interested people can get on your email list Invest in a working with a business coach in stage one ONLY if you think they will help you get it done faster, you can pay for that help without going into debt, and it costs an amount you can soon make back. Find a person or program who will help you only focus on those first 3 steps until you've gotten through them. Once you've served some people with your pilot, you've got a business and you can start discerning what you're going to do next grow your business. You're in stage 2. Stage 2 is when you can focus on reaching more people, honing your messaging, and reiterating and improving your offer. I've got a program for you to get you all the way through those first 3 steps of stage 1 in 8 weeks. It's called Create Your Program. I designed CYP to help you start a solid business beyond private practice, whether that's gonna be your main thing or a profitable side hustle. Some people come to CYP as their first move beyond private practice. Other folks come to CYP after they've invested in programs where they learned marketing strategies their businesses weren't ready for. After CYP they're in a much better position to use what they learned in those other programs. ->The waitlist is open now. Get on it so you hear when I open registration. In CYP I guide you step-by-step from niching all the way through launching a pilot program. This is a small group experience where you'll get a lot of brave work done in a supportive group of driven and open hearted entrepreneurs like you. If you're worried about the legal part of this, you are not alone. We have a guest attorney come in to answer your legal questions and recommend your first steps in that area. The last two times I opened registration, CYP filled early, so do make sure you're on the waitlist so that you hear as soon as it opens. Show notes at https://rebeltherapist.me/podcast/188

On this episode of the Real Life Pharmacology podcast, I discuss carvedilol pharmacology, drug interactions, and adverse effects. Carvedilol is one of the few beta-blockers that has alpha-blocking activity. Carvedilol is almost exclusively metabolized by various CYP enzymes so renal function changes typically don't change drug concentrations to a significant extent. Beta-blockers like carvedilol are well known to cause the adverse effects of fatigue and sexual dysfunction.

CYP 36 - Credit where Credit is dueYes, I did post a toilet on my Instagram feed this week. I was hesitant but then I thought….WHY the heck not…… and I'll tell you why…..Listen in....its a good one.Hey everyone…….If you love this or know someone that needs it, share it!! Or get over to apple podcasts and leave a quick positive review. Also check out any links in today's show notes for the Instagram page where you can also find some amazing resources and a little tough love  If you are ready for some help or even a conversation, hit me up! I am always ready to chat.  Take care and have a great day and I'll see ya next week……..

On this episode of the PAIN POD, Mark “Pain Guy” Garofoli will chat with Dr. Eric Christianson, a nationally recognized pharmacology expert, about drug interactions with particular attention in the pain management realm. CYP-450, of course, Serotonin Syndrome, we'll give the down and dirty on explain what all the hub bub is about, and might even have a conversation for our snowbirds out there and everyone else who enjoys grapefruit juice! Considering drug interaction database flag every medication known to mankind, and yet with completely different recommendations, it's best to hear it from the source as to how in the world to best help our patients in pain. Listen in, right here, right now, on the Pain Pod. Come one, come all, to the Pain Pod!!! MedEd101 https://www.meded101.com/ Real Life Pharmacology (Grapefruit Juice Interaction Podcast Episode) https://www.reallifepharmacology.com/grapefruit-juice-interactions/ AGS Beers List (2019) https://geriatricscareonline.org/toc/american-geriatrics-society-updated-beers-criteria/CL001 Chicago Tribune Drug Interaction Secret Patient Article (2016) https://www.chicagotribune.com/investigations/ct-drug-interactions-pharmacy-met-20161214-story.html Learn more about your ad choices. Visit megaphone.fm/adchoices

When do post-marketing tests required by FDA not indicate a reasonable expectation of success for a drug combination? And, what is the interplay between reasonable expectation of success and disclosed ranges in prior art? Allison Schmitt (BCLT) and Brian Matsui (MoFo) discuss the Teva v. Corcept decision (18 F.4th 1377 (Fed. Cir. 2021)). Featuring Allison Schmitt (BCLT) and Brian Matsui (MoFo). SPEAKERS Brian Matsui, Allison Schmitt Allison Schmitt 00:00 Hello and welcome to the Berkeley Center for Law and Technology's expert series podcast. My name is Allison Schmitt, and I'm the director of the life sciences project at BCLT. Today, Brian Matsui for Morrison and Forester is joining us for our podcast series beyond the holding a nuanced look at the Federal Circuit's patent decisions. Thanks for joining us again, Brian. Brian Matsui 00:19 Thanks, Ellison. Allison Schmitt 00:21 So today we're going to discuss the recent Life Sciences decision. Teva Pharmaceutical versus Corcept Therapeutics. This is an appeal from a p tag decision on obviousness from a post grant review. We'll go ahead and let Brian take it, take it away. Walk me through the decision. Brian Matsui 00:36 Great. Yeah. So this is a decision that came out in December 7. And it's it's an interesting obviousness decision. It's one of those decisions where you you take a look at it. And I think the first reaction that a lot of people have is there was clearly strong motivation. And it's one of those cases where people think, well, the claims here really seemed like they might be obvious, just as a bit of background. This involves the patent owner Corcept. And basically, they did a clinical trial on a drug mifepristone for Cushing syndrome. And they basically found out from their clinical trial that there are good results for dosages of 300 to 1200 milligrams per day, and they, you know, submitted a new drug application to the FDA, which got approved, but during the approval, they FDA included some post marketing requirements. They basically require the patent owner to do a clinical trial to see if there was a drug to drug interaction between Mfu Crosstown and another type of drug like a strong CYP three a inhibitor, the FDA wanted to see if there's a safety risk if you use those together. So basically, they had to do this additional clinical study. But the drug was approved for 300 milligrams all the way up to 1200 milligrams. But there was a bit of a limitation on that, that you were only supposed to dose at 300 milligrams per day with that other drug that they wanted the patent owner to do a study on. And so this is where it got interesting because course up did a study. And they found out that you could tolerate up to 600 milligrams per day with this strong CYP three a inhibitor and they got a patent on that. And so basically, the FDA told them, you know, in what would be a prior art document that you need to do this, and they did it. And they ended up getting a patent on that. So as a result, Teva sought post grant review, and they thought they had a pretty strong obviousness case, I would think, because they basically had the FDA saying do the study to the patent owner, the patent owner does the study. And then that's what leads to the actual grant of the patent. Well,

Episode 21 of Cracking Addiction explores methadone pharmacokinetics, breakdown and interactions within the body and interactions with other drugs. Methadone is a drug with a wide variability in its absorption with oral bio-availability ranges from 35% to 100%. This is a significant amount of variability and explains why the same dose of Methadone can impact different patients differently. Methadone is metabolised within the liver by the cytochrome P450 enzymes but mainly 3A4. There is a 17-fold inter-individual variation of methadone blood concentration for a given dosage and variations in metabolism account for a large part of this variation. Kinetic interactions influenced by the CYP 450 enzyme can affect plasma methadone levels. • Inducers of CYP450 can • Accelerate the metabolism of methadone • lower methadone plasma levels • Precipitate opioid withdrawal • Inhibitors of CYP450 can • Slow the metabolism of methadone • Increase plasma levels • Produce opioid toxicity (sedation, overdose) Methadone is excreted renally with approximately 10% of drug renally eliminated unchanged. Renal excretion of methadone urinary pH dependent with increased Methadone excretion noted at pH less than 6 and decreased Methadone excretion at higher pH levels. About Meducate ® Meducate provides online education for doctors, clinicians, health professionals and the public. See the website to browse the many different talks and courses availablehttps://www.meducate.com.au

Ben, Demetrius, and Cyp (one of the founders of ReDefine:RVA) get together and discuss the current climate including racism, police, BLM, and other things that contribute to what we're seeing today. Such an amazing conversation

In this episode, we have John Lenkey and another special guest, Jason Arntz. We talked about products, contest history, as well as anabolics and other compounds. Topics: Jason's products His thoughts on intra workout nutrition What Ornithine is The biggest highlights of his amateur and professional careers The reason he left bodybuilding Trevor's gym business Why John likes to use anabolics Why work ethic is less and less in everything New equipments in the gym Links: TGB Supplements Email Address: info@tgbsupplements.com TGB Supplements on Facebook TGB Supplements on Instagram