Podcasts about b12

On this episode, we define anemia and describe its clinical presentations, classifications, and underlying etiologies. We evaluate current guidelines and evidence-based strategies for diagnosing and managing different types of anemia, including iron-deficiency, vitamin B12/folate-deficiency, and anemia of chronic disease.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. For existing Unlimited (Gold) freeCE members, this CE option is included in your membership benefits at no additional cost! A password, which will be given at some point during this episode, is required to access the post-activity test. To earn credit for this episode, visit the following link below to go to freeCE's website: https://www.freece.com/ If you're not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their website and earn CE for listening to this podcast. Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. If you purchase an annual membership, you'll also get a free digital copy of High-Powered Medicine 3rd edition by Dr. Alex Poppen, PharmD. HPM is a book/website database of summaries for over 150 landmark clinical trials.You can visit our Patreon page at the website below:  www.patreon.com/corconsultrx We want to give a big thanks to Dr. Alex Poppen, PharmD and High-Powered Medicine for sponsoring the podcast..  You can get a copy of HPM at the links below:  Purchase a subscription or PDF copy - https://highpoweredmedicine.com/ Purchase the paperback and hardcover - Barnes and Noble website We want to say thank you to our sponsor, Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx We also want to thank our sponsor Freed AI. Freed is an AI scribe that listens, prepares your SOAP notes, and writes patient instructions. Charting is done before your patient walks out of the room. You can try 10 notes for free and after that it only costs $99/month. Visit the website below for more information: https://www.getfreed.ai/  If you have any questions for Cole or me, reach out to us via e-mail: Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com

Blind since birth, Mike Hingson was on the 78th floor of the World Trade Center when the planes hit on September 11th, 2001. With his guide dog Roselle, he navigated chaos, panic, and smoke to escape.In this powerful conversation, Mike shares:What really happened inside the TowersLessons of leadership, resilience, and griefHow to face the unexpected with courage

Dr. Pedro Barata and Dr. Rana McKay discuss the integration of innovative advances in molecular imaging and therapeutics to personalize treatment for patients with renal cell and urothelial carcinomas. TRANSCRIPT Dr. Pedro Barata: Hello, I'm Dr. Pedro Barata, your guest host of By the Book, a podcast series featuring insightful conversations between authors and editors of the ASCO Educational Book. I'm a medical oncologist at University Hospitals Seidman Cancer Center and an associate professor of medicine at Case Western Reserve University in Cleveland, Ohio. I'm also an associate editor of the ASCO Educational Book. Now, we all know the field of genitourinary cancers (GU) is evolving quite rapidly, and we have new innovations in molecular imaging as well as targeted therapeutics. Today's episode will be exploring novel approaches that are transforming the management of renal cell and urothelial carcinomas and also their potential to offer a more personalized treatment to patients. For that, joining for today's discussion is Dr. Rana McKay, a GU medical oncologist and professor at University of California San Diego. Dr. McKay will discuss her recently published article titled, “Emerging Paradigms in Genitourinary Cancers: Integrating Molecular Imaging, Hypoxia-Inducible Factor-Targeted Therapies, and Antibody-Drug Conjugates in Renal Cell and Urothelial Carcinomas.”  Our full disclosures are available in the transcript of this episode.  And with that, Rana McKay, great to have you on the podcast today. Dr. Rana McKay: Oh, thank you so much, Dr. Barata. It's really wonderful to be here with you. So, thanks for hosting. Dr. Pedro Barata: No, thanks for taking the time, and I'm looking forward to this conversation. And by the way, let me start by saying congrats on a great article in the Educational Book. Really super helpful paper. I'm recommending it to a lot of the residents and fellows at my own institution. I would like to first ask you to kind of give our listeners some context of how novel approaches in the molecular imaging as well as targeted therapeutics are actually changing the way we're managing patients with GU, but specifically with renal cell carcinoma and urothelial carcinoma. So, what are the areas you would call out as like being big areas for innovation in this context, and why are they important? Dr. Rana McKay: Very good question. And I think this is really what this article highlights. It highlights where are we going from an imaging diagnostics standpoint? Where are we going from a therapeutic standpoint? And I think if we have to step back, from the standpoint of diagnostics, we've seen PET imaging really transform diagnostics in prostate cancer with the advent of PSMA PET imaging, and now PSMA PET imaging is used as a biomarker for selection for theranostics therapy. And so, we're starting to see that enter into the RCC landscape, enter into the urothelial cancer landscape to a lesser extent. And I think it's going to potentially be transformative as these tools get more refined. I think when we think about therapeutics, what's been transformative most recently in the renal cell carcinoma landscape has been the advent of HIF2α inhibition to improve outcomes for patients. And we have seen the approval of belzutifan most recently that has reshaped the landscape. And now there's other HIF2α inhibitors that are being developed that are going to be further important as they get refined. And lastly, I think when we think about urothelial carcinoma, the greatest transformation to treatment in that context has been the displacement of cisplatin and platinum-based chemotherapy as a frontline standard with the combination of enfortumab vedotin plus pembrolizumab. And we've seen antibody-drug conjugates really reshape treatment and tremendously improve outcomes for patients. So, I think those are the three key areas of interest. Dr. Pedro Barata: So with that, let's focus first on the imaging and then we'll get to the therapeutic area. So, we know there's been a paradigm shift, really, when prostate-specific targets emerged as tracers for PET scanning. And so, we now commonly use prostate-specific membrane antigen, or PSMA-based PET scanning, and really transform how we manage prostate cancer. Now, it appears that we're kind of seeing a similar wave in renal cell carcinoma with the new radiotracer against the target carbonic anhydrase IX. What can you tell us about this? And is this going to be available to us anytime soon? And how do you think that might potentially change the way we're managing patients with RCC today? Dr. Rana McKay: First, I'll step back and say that in the context of PSMA PET imaging, we have actually been able to better understand RCC as well. So, we know that PSMA is expressed in the neovasculature of tumors, and it can actually be used to detect renal cell carcinoma tumors. It has a detection rate of about 84% when used for detection. And so, you know, I don't think it's just restricted to carbonic anhydrase IX, but we will talk about that. So, PSMA expressed in the neovasculature has a detection rate of around 84%, particularly if we're looking at clear cell RCC. CAlX is overexpressed in clear cell RCC, and it's actually used in diagnosing renal cell carcinoma when we think of CAlX IHC for diagnosing clear cell RCC. And now there are CAlX PET tracers. The first foray was with the ZIRCON study that was actually an interestingly designed study because it was designed to detect the likelihood of PET imaging to identify clear cell RCC. So, it was actually used in the early diagnostics setting when somebody presents with a renal mass to discriminate that renal mass from a clear cell versus a non-clear cell, and it was a positive study. But when I think about the potential application for these agents, you know, I think about the entire landscape of renal cell carcinoma. This is a disease that we do treat with metastasis-directed therapy. We have certainly seen patients who've undergone metastasectomy have long, durable remissions from such an approach. And I think if we can detect very early onset oligometastatic disease where a metastasis-directed therapy or SABR could be introduced - obviously tested in a trial to demonstrate its efficacy - I think it could potentially be transformative. Dr. Pedro Barata: Wonderful. It's a great summary, and I should highlight you are involved in some of those ongoing studies testing the performance of this specific PET scanning for RCC against conventional imaging, right? And to remind the listeners, thus far, for the most part, we don't really do FDG-PET for RCC. There are some specific cases we do, but in general, they're not a standard scanning. But maybe that will change in the future. Maybe RCC will have their own PSMA-PET. And to your point, there's also emerging data about the role of PSMA-PET scanning in RCC as well, as you very elegantly summarized. Wonderful. So, let me shift gears a little bit because you did, in your introduction, you did highlight a novel MOA that we have in renal cell carcinoma, approved for use, initially for VHL disease, and after that for sporadic clear cell renal cell carcinoma. We're talking about hypoxia-inducible factor 2-alpha inhibitors, or HIF2α inhibitors, such as belzutifan. But there's also others coming up. So, as a way to kind of summarize that, what can you tell us about this breakthrough in terms of therapeutic class, this MOA that got to our toolbox of options for patients with advanced RCC? Tell us a little bit what is being utilized currently in the management of advanced RCC. And where do you see the future going, as far as, is it moving early on? Is it getting monotherapy versus combinations? Maybe other therapies? What are your thoughts about that? What can you tell us about it? Dr. Rana McKay: Belzutifan is a first-in-class HIF2α inhibitor that really established clinical validation for HIF2α as a therapeutic target. When we think about the activity of this agent, the pivotal LITESPARK-005 trial really led to the approval of belzutifan in patients who were really heavily pretreated. It was patients who had received prior IO therapy, patients who had received prior VEGF-targeted therapy. And in the context of this study, we saw a median PFS of 5.6 months, and there did seem to be a tail on the curve when you looked at the 12-month PFS rate with belzutifan. It was 33.7% compared to 17.6% with everolimus. And then when we look at the response rate, it was higher with belzutifan on the order of 22-23%, and very low with everolimus, as we've previously seen. I think one of the Achilles heels of this regimen is the primary PD rate, which was 34% when used in later line. There are multiple studies that are testing belzutifan in combination across the treatment landscape. So, we have LITESPARK-011, which is looking at the combination of belzutifan plus lenvatinib in the second-line setting. We've got the MK-012 [LITESPARK-012] study, which is looking at belzutifan in various combinations in the frontline setting. So there is a combination with IO plus belzutifan. And so this is also being looked at in that context. And then we also have the LITESPARK-022 study, which is looking at pembrolizumab with belzutifan in the adjuvant setting. So there's a series of studies that will be exploring belzutifan really across the treatment landscape. Many of these studies in combination. Additionally, there are other HIF2α inhibitors that are being developed. We have casdatifan, which is another very potent HIF2α inhibitor. You know, I think pharmacologically, these are different agents. There's a different half-life, different dosing. What is going to be the recommended phase 3 dose for both agents, the EPO suppression levels, the degree of EPO suppression, and sustainability of EPO suppression is very different. So, I think we've seen data from casdatifan from the ARC-20 trial from monotherapy with a respectable response rate, over 30%, primary PD rate hovering just around 10%.  And then we've also seen data of the combination of casdatifan with cabozantinib as well that were recently presented this year. And that agent is also being tested across the spectrum of RCC. It's being looked at in combination with cabozantinib in the PEAK-1 study, and actually just at the KCRS (Kidney Cancer Research Summit), we saw the unveiling of the eVOLVE-RCC trial, which is going to be looking at a volrustomig, which is a PD-1/CTLA-4 inhibitor plus casdatifan compared to nivo-ipi in the frontline setting.  So, we're going to see some competition in this space of the HIF2α inhibitors. I think when we think of mechanism of action in that these are very potent, not a lot of off-target activity, and they target a driver mutation in the disease. And that driver mutation happens very early in the pathogenesis. These are going to be positioned much earlier in the treatment landscape. Dr. Pedro Barata: All these studies, as you're saying, look really promising. And when we talk about them, you mentioned a lot of combinations. And to me, when I think of these agents, it makes a lot of sense to combine because there's not a lot of overlapping toxicities, if you will. But perhaps for some of our listeners, who have not used HIF2α inhibitors in practice yet, and they might be thinking about that, what can you tell us about the safety profile? How do you present it to your patients, and how do you handle things like hypoxia or anemia? How do you walk through the safety profile and tolerability profile of those agents like belzutifan? Dr. Rana McKay: I think these drugs are very different than your traditional TKIs, and they don't cause the classic symptoms that are associated with traditional TKIs that many of us are very familiar with like the rash, hand-foot syndrome, hypertension, diarrhea. And honestly, these are very nuanced symptoms that patients really struggle with the chronicity of being on a chronic daily TKI. The three key side effects that I warn patients about with HIF2α inhibitors are: (1) fatigue; (2) anemia; and (3) hypoxia and dysregulation in the ability to sense oxygen levels. And so, many of these side effects - actually, all of them - are very dose-dependent. They can be very well-managed. So, we can start off with the anemia. I think it's critically important before you even start somebody on belzutifan that you are optimizing their hemoglobin and bone marrow function. Make sure they don't have an underlying iron deficiency anemia. Make sure they don't have B12 or folate deficiency. Check for these parameters. Many patients who have kidney cancer may have some hematuria, other things where there could be some low-level blood loss. So, make sure that those are resolved or you're at least addressing them and supplementing people appropriately. I monitor anemia very closely every 3 to 4 weeks, at least, when people start on these medications. And I do initiate EPO, erythropoietin, should the anemia start to worsen. And I typically use a threshold of around 10g/dL  for implementing utilization of an EPO agent, and that's been done very safely in the context of the early studies and phase 3 studies as well. Now, with regards to the hypoxia, I think it's also important to make sure that you're selecting the appropriate individual for this treatment. People who have underlying COPD, or even those individuals who have just a very high burden of disease in their lung, lymphangitic spread, pleural effusions, maybe they're already on oxygen - that's not an ideal candidate for belzutifan. Something that very easily can be done in the clinic before you think about initiating somebody on this treatment, and has certainly been integrated into some of the trials, is just a 6-minute walk test. You know, have the patient walk around the clinic with one of the MAs, one of the nurses, put the O2 sat on [measuring oxygen saturation], make sure they're doing okay. But these side effects, like I said, are very dose-dependent. Typically, if a patient requires, if the symptoms are severe, the therapy can be discontinued and dose reduced. The standing dose is 120 mg daily, and there's two dose reductions to 80 mg and 40 mg should somebody warrant that dose modification. Dr. Pedro Barata: This is relatively new, right? Like, it was not that we're used to checking oxygen levels, right? In general, we're treating these patients, so I certainly think there's a learning curve there, and some of the points that you highlight are truly critical. And I do share many of those as well in our practice. Since I have you, I want to make sure we touch base on antibody-drug conjugates as well. It's also been a hot area, a lot of developments there. When I think of urothelial carcinoma and renal cell carcinoma, I see it a little bit different. I think perhaps in urothelial carcinoma, antibody-drug conjugates, or ADCs, are somewhat established already. You already mentioned enfortumab vedotin. I might ask you to expand a little bit on that. And then in renal cell carcinoma, we have some ADCs as well that you include in your chapter, and that I would like you to tell us what's coming from that perspective. So, tell us a little bit about how do you see ADCs in general for GU tumors, particularly UC and RCC? Tell us a little bit about the complexity or perhaps the challenges you still see. At the same time, tell us about the successes. Dr. Rana McKay: Stepping back, let's just talk about like the principles and design of ADCs. So, most ADCs have three components. There's a monoclonal antibody that typically targets a cell surface antigen, which is conjugated by a linker, which is the second component, to a payload drug. And typically, that payload drug has been chemotherapy, whether it be topoisomerase or whether it be MMAE or other chemotherapeutic. We can start in the RCC space. There's been multiple antibody-drug conjugates that have been tested. There's antibody-drug conjugates to CD70, which is expressed on clear cell RCC. There's been antibody-drug conjugates to ENPP3, which is also expressed on RCC. There's antibody-drug conjugates to CDH6. And they have different payloads, like I said, whether it be topoisomerase I or other microtubule inhibitors. Now, when we think about kidney cancer, we don't treat this disease with chemotherapy. This disease is treated with immunotherapy. It is treated with treatments that target the VEGF pathway and historically has not been sensitive to chemo. So, I think even though the targets have been very exciting, we've seen very underwhelming data regarding activity, and in some context, seen increased toxicity with the ADCs. So, I think we need to tread lightly in the context of the integration and the testing of ADCs in RCC. We just came back from the KCRS meeting, and there was some very intriguing data about a c-Kit ADC that's being developed for chromophobe RCC, which is, you know, a huge unmet need, these variant tumors that really lack appropriate therapeutics. But I just caution us to tread lightly around how can we optimize the payload to make sure that the tumor that we're treating is actually sensitive to the agent that's targeting the cell kill. So, that's a little bit on the ADCs in RCC. I still think we have a long way to go and still in early testing. Now, ADCs for UC are now the standard of care. I think the prototypical agent, enfortumab vedotin, is a nectin-4-directed ADC that's conjugated to an MMAE payload and was the first ADC approved for advanced urothelial, received accelerated approval following the EV-201 trial, which was basically a multicenter, single-arm study that was investigating EV in cisplatin-ineligible patients with advanced urothelial carcinoma, and then ultimately confirmed in the EV-301 study as well. And so, that study ended up demonstrating the support superiority of EV from an overall survival standpoint, even PFS standpoint. Building on that backbone is the EV-302 study, which tested EV in combination with pembrolizumab versus platinum-based chemotherapy in the frontline setting. And that was a pivotal, landmark study that, like I said, has displaced platinum therapy as a frontline treatment for people with advanced urothelial carcinoma. And when we think about that study and the median overall survival and just how far we've come in urothelial cancer, the median OS with EV-pembro from that trial was 31 and a half months. I mean, that's just incredible. The control arm survival was 16 and a half months. The hazard ratio for OS, 0.47. I mean this is why when this data was presented, it was literally a standing ovation that lasted for several minutes because we just haven't seen data that have looked that good. And there are other antibody-drug conjugates that are being tested. We've all been involved in the saga with sacituzumab govitecan, which is a trophoblast cell surface antigen 2 (Trop-2) targeted ADC with a topoisomerase I payload. It was the second ADC to receive approval, but then that approval was subsequently withdrawn when the confirmatory phase 3 was negative, the TROPiCS-04 trial. So, approval was granted based off of the TROPHY-U-01, single-arm, phase 2 study, demonstrating a response rate of around 28% and a PFS of, you know, about 5 and a half months. But then failure to show any benefit from an OS standpoint. And I think there's a lot of controversy in the field around whether this agent still has a role in advanced urothelial carcinoma. And I think particularly for individuals who do not have molecular targets, like they're not HER2-amplified or have HER2-positivity or FGFR or other things like that. Dr. Pedro Barata: Fantastic summary, Rana. You were talking about the EV, and it came to mind that it might not be over, right, for the number of ADCs we use in clinical practice in the near future. I mean, we've seen very promising data for ADC against the HER2, right, and over-expression. It also can create some challenges, right, in the clinics because we're asking to test for HER2 expression. It's almost like, it's not exactly the same to do it in breast cancer, but it looks one more time that we're a little bit behind the breast cancer field in a lot of angles. And also has vedotin as a payload. Of course, I'm referring to disitamab vedotin, and there's very elegant data described by you in your review chapter as well. And it's going to be very interesting to see how we sequence the different ADCs, to your point as well. So, before we wrap it up, I just want to give you the opportunity to tell us if there's any area that we have not touched, any take-home points you'd like to bring up for our listeners before we call it a day. Dr. Rana McKay: Thank you so much. I have to say, you know, I was so excited at ASCO this year looking at the GU program. It was fantastic to see the progress being made, novel therapeutics that really there's a tremendous excitement about, not just in RCC and in UC, but also in prostate cancer, thinking about the integration of therapies, not just for people with refractory disease that, even though our goal is to improve survival, our likelihood of cure is low, but also thinking about how do we integrate these therapies early in the treatment landscape to enhance cure rates for patients, which is just really spectacular. We're seeing many of these agents move into the perioperative setting or in combination with radiation for localized disease. And then the special symposium on biomarkers, I mean, we've really come a long, long way. And I think that we're going to continue to evolve over the next several years. I'm super excited about where the field is going in the treatment of genitourinary malignancies. Dr. Pedro Barata: Oh, absolutely true. And I would say within the Annual Meeting, we have outstanding Educational Sessions. And just a reminder to the listeners that actually that's where the different teams or topics for the Educational Book chapters come from, from actually the educational sessions from ASCO. And your fantastic chapter is an example of that, right, focusing on advanced GU tumors. So, thank you so much, Rana, for taking the time, sharing your insights with us today on the podcast. It was a fantastic conversation as always. Dr. Rana McKay: My pleasure. Thanks so much for having me, Dr. Barata. Dr. Pedro Barata: Of course.  And thank you to our listeners for your time today. You will find the link to the article discussed today in the transcript of this episode. I also encourage you to check out the 2025 ASCO Educational Book. You'll find an incredible wealth of information there. It's free, available online, and you'll find, hopefully, super, super important information on the key science and issues that are shaping modern oncology, as we've heard from Dr. McKay and many other outstanding authors. So, thank you, everyone, and I hope to see you soon. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:        Dr. Pedro Barata @PBarataMD Dr. Rana McKay @DrRanaMcKay Follow ASCO on social media:        @ASCO on X (formerly Twitter)        ASCO on Bluesky       ASCO on Facebook        ASCO on LinkedIn        Disclosures:     Dr. Pedro Barata: Stock and Other Ownership Interests: Luminate Medical Honoraria: UroToday Consulting or Advisory Role: Bayer, BMS, Pfizer, EMD Serono, Eisai, Caris Life Sciences, AstraZeneca, Exelixis, AVEO, Merck, Ipson, Astellas Medivation, Novartis, Dendreon Speakers' Bureau: AstraZeneca, Merck, Caris Life Sciences, Bayer, Pfizer/Astellas Research Funding (Inst.): Exelixis, Blue Earth, AVEO, Pfizer, Merck  Dr. Rana McKay: Consulting or Advisory Role: Janssen, Novartis, Tempus, Pfizer, Astellas Medivation, Dendreon, Bayer, Sanofi, Vividion, Calithera, Caris Life Sciences, Sorrento Therapeutics, AVEO, Seattle Genetics, Telix, Eli Lilly, Blue Earth Diagnostics, Ambrx, Sumitomo Pharma Oncology, Esiai, NeoMorph, Arcus Biosciences, Daiichi Sankyo, Exelixis, Bristol Myers Squibb, Merck, Astrazeneca, Myovant Research Funding (Inst.): Bayer, Tempus, AstraZeneca, Exelixis, Bristol Myers Squibb, Oncternal Therapeutics, Artera    

Osteopathic medical student Scarlett Saitta discusses her article "Integrating vitamin education in mental health care," highlighting the growing evidence that nutritional deficiencies can profoundly impact psychiatric outcomes. Scarlett explains how deficiencies in vitamin D, B12, and folate are common in patients with depression, and how targeted supplementation can dramatically improve treatment response and reduce hospitalizations. She emphasizes that nutritional psychiatry is evidence-based, not alternative medicine, and advocates for its integration into medical education and clinical practice. Listeners will gain actionable insights on screening for deficiencies, reframing nutrition as science-based care, and adopting low-cost, high-yield strategies to support better mental health outcomes. Our presenting sponsor is Microsoft Dragon Copilot. Microsoft Dragon Copilot, your AI assistant for clinical workflow, is transforming how clinicians work. Now you can streamline and customize documentation, surface information right at the point of care, and automate tasks with just a click. Part of Microsoft Cloud for Healthcare, Dragon Copilot offers an extensible AI workspace and a single, integrated platform to help unlock new levels of efficiency. Plus, it's backed by a proven track record and decades of clinical expertise—and it's built on a foundation of trust. It's time to ease your administrative burdens and stay focused on what matters most with Dragon Copilot, your AI assistant for clinical workflow. VISIT SPONSOR → https://aka.ms/kevinmd SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

We're continuing the protein conversation I started in Are You Getting Enough Protein? (Part One and Part Two). In those episodes, I unpacked why amino acids from plant and animal sources are identical, why the RDA is just a minimum, and why being intentional about protein matters as we level up in age and fitness.Paid subscribers enjoy printable resources and my recipe for Homemade Seitan, so join the club today!In this episode,* I explain why “lean protein” really means plants.* I show why plant protein being “less concentrated” is actually a feature, not a bug.* I share why the protein-to-calorie ratio is such a helpful measurement, especially if your goal is fat loss and muscle gain.* I focus on plant foods that are both protein-rich and practical to eat (spoiler: I'm not eating 5 tablespoons of spirulina a day).* I parse out the 4 categories of protein-rich plant foods:*

Donatas Urbonas, Jonas Miklovas ir Augustas Šuliauskas tiesioginėje „BasketNews.lt podkasto” transliacijoje aptaria fantastinę Lietuvos rinktinės pergalė Europos čempionato aštuntfinalyje. Rimo Kurtinaičio auklėtiniai 88:79 pranoko Latvijos rinktinę ir žengė tarp aštuonių stipriausių pirmenybių komandų. Tinklalaidės partneriai: – Antėja“ siūlo stiprų „dvigubą dublį“ – vitamino D ir vitamino B12 tyrimų paketas vos už 29 Eur. Imunitetas + (plius) energija viename pasiūlyme – kad rudens dienos būtų stipresnės ir gyvybingesnės! https://www.anteja.lt/menesio-pasiulymai/imunitetas-energija – EuroBasket 2025 žiūrėkite per Telia Play. Krepšinis, filmai, serialai – viskas vienoje vietoje, visur, kur tik norit. Daugiau: https://www.telia.lt/privatiems/televizija/planai – Nealkoholinis alus „Gubernija”, daugiau informacijos – https://gubernija.lt/ Temos: Susipažinkite: Arnas Žvėrička (0:00); Genialiai laimėta trenerių dvikova (4:46); 24 mestos baudos per ketvirtąjį kėlinį (9:33); Kas kuo tikėjo ir netikėjo? (10:34); Ar tai – latvių fiasko? (13:17); Deivido Sirvydžio prisikėlimas (15:08); Trečias iš eilės Ąžuolo Tubelio dvigubas dublis (16:54); Ikoninė minutės pertraukėlė (19:56); Nereikalingos JV emocijos (21:56); Kaip su Velička baudėme latvius (29:06); Fantastiniai „Neptūno” pasirinkimai (30:30); Graikija ar Izraelis ketvirtfinalyje? (32:43); Veličkos motyvacija prieš rungtynes (41:42); Laukia dar vienas revanšas? (43:22); Nereikalingas žurnalistų ir rinktinės supriešinimas (48:38); Pirmoji atkrintamųjų pergalė nuo 2015 m. (52:06); Šturmuojame Rygą! (55:31).

In this encore episode, we highlight the stomach's role in vitamin B12 absorption and bioavailability, detailing the cellular composition of the gastric mucosa and further highlighting mucous cells, parietal cells, and chief cells. We also briefly discuss Helicobacter pylori and common symptoms, while detailing H. pylori's potential impacts on the gastric mucosal barrier. Topics:1. Introduction- Overview of the stomach's role in B12 absorption- Helicobacter pylori  2. H. pylori Overview- Gram-negative bacterium, can colonize the stomach lining- Many individuals remain asymptomatic- Symptoms - Can contribute to gastritis and peptic ulcers- Produces urease, hydrolyzes urea into ammonia (NH₃) andcarbon dioxide (CO₂)- Ammonia neutralizes stomach acid locally, protective microenvironment- H. pylori damages the mucosal barrier and contributes to persistence- Possesses additional virulence factors 3. Gastric Anatomy  -  Stomach is divided into the cardia, fundus, body, and pylorus- The gastric mucosa - The epithelial lining; mucous cells, parietal cells, chief cells, and more 4. Mucous Cells and Mucosal Protection  - Line the gastric pits and secrete thick, viscous mucus- Mucus composed of water, mucin glycoproteins, and other low-molecular-weight molecules- Traps bicarbonate ions (HCO₃⁻)- Shields the stomach lining 5. Parietal Cells  - Located in the gastric glands, predominantly in the fundus and body- Secrete hydrochloric acid (HCl)- Secrete intrinsic factor (IF) 6. Vitamin B12 Overview - Cobalamin: DNA synthesis, red blood cell formation, neurological function, methylation, and more- Methylcobalamin and 5-deoxyadenosylcobalamin- Non-active forms include hydroxocobalamin and synthetic cyanocobalamin   7. Vitamin B12 Absorption Pathway  - B12 is released from proteins by HCl and pepsin- Binds first to haptocorrin- In the small intestine, pancreatic enzymes degrade haptocorrin- B12 binds intrinsic factor - Absorption in the ileum - Impairment  8. Chief Cells  - Located in the gastric glands- Secrete pepsinogen, activated by acid into pepsin- Also secrete gastric lipase 9. Hydrochloric Acid (HCl) - Secreted by parietal cells- Denatures dietary proteins and activates pepsinogen- Acts as a defense mechanism by aiding in sterilizing ingested food 10. Relevance of H. pylori - Produces urease that breaks down urea into NH₃ and CO₂- Ammonia neutralizes acid locally, forming a protective “bubble”- Enhances mucosal damage and microbial persistence 11. B12 Absorption  - Multiple factors and root causes can impair absorption- H. pylori 12. Hypochlorhydria  - Symptoms- Absorption: vitamin B12, iron, calcium, magnesium, more- Small Intestinal Bacterial Overgrowth (SIBO)  13. Conclusion- Multi-factorial, root cause approachThank you to our episode sponsor: 1. ⁠⁠⁠⁠⁠⁠OmneDiem®'s⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Histamine Digest®⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠Histamine Digest® PureMAX⁠⁠⁠⁠⁠⁠ : Use code STXAL9VI for 15% off.2. ⁠⁠⁠⁠⁠⁠Histamine Digest® Histamine Complete⁠⁠⁠⁠⁠⁠ with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

Chorea describes involuntary movements that are random, abrupt, and unpredictable, flowing from one body part to another. The most common cause of genetic chorea in adults is Huntington disease, which requires comprehensive, multidisciplinary care as well as support for care partners, who may themselves be diagnosed with the disease. In this episode, Aaron Berkowitz, MD, PhD FAAN speaks with Kathryn P. L. Moore, MD, MSc, author of the article “Huntington Disease and Chorea” in the Continuum® August 2025 Movement Disorders issue. Dr. Berkowitz is a Continuum® Audio interviewer and a professor of neurology at the University of California San Francisco in the Department of Neurology in San Francisco, California. Dr. Moore is an assistant professor and director of the Parkinson's Disease and Movement Disorders Fellowship in the department of neurology at Duke University in Durham, North Carolina. Additional Resources Read the article: Huntington Disease and Chorea Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @AaronLBerkowitz Guest: @KatiePMooreMD Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Berkowitz: This is Dr Aaron Berkowitz with Continuum Audio, and today I'm interviewing Dr Kathryn Moore about her article on diagnosis and management of Huntington disease and chorea, which appears in the August 2025 Continuum issue on movement disorders. Welcome to the podcast, Dr Moore. Could you please introduce yourself to our audience? Dr Moore: Yeah, thank you so much. I'm so excited to be here. I'm Dr Moore. I'm an assistant professor of neurology at Duke University, where I work as a movement disorder specialist. I run our fellowship there and help with our residency program as well. So, I'm excited to speak with our listeners about chorea today. Dr Berkowitz: Fantastic. And we're excited to talk to you about chorea. So, as a general neurologist myself, I only see chorea pretty rarely compared to other movement disorders like tremor, myoclonus, maybe the occasional tic disorder. And like anything I don't see very often, I always have to look up the differential diagnosis and how to evaluate a patient with chorea. So, I was so glad to read your article. And next time I see a patient with chorea, I know I'll be referring to your article as a great reference to have a framework for how to approach it. I hope our readers will look at all these helpful tables on differential diagnosis based on distribution of chorea in the body, potential etiologies, time course of onset and evolution, associated drug-induced causes, what tests to send. So, I highly recommend our listeners read the article. Keep those tables handy for when a patient comes in with chorea. I'm excited to pick your brain about some of these topics today. First, how do you go about distinguishing chorea from other hyperkinetic movement disorders when you see a patient that you think might have chorea? Dr Moore: One of the wonderful things about being a movement disorder specialist is we spend a lot of time looking at movements and training our brain to make these distinctions. The things that I would be looking out for chorea is involuntary, uncontrolled movements that appear to be brief and flowing from one part of the body to another. So, if you can watch a patient and predict what movements they're going to do, this probably isn't chorea. And it should be flowing from one part of the body to another. So, not staying just in one part of the body or having sustained movements. It can be difficult to distinguish between a tic or dystonia or myoclonus. Those things tend to be more predictable and repetitive than the chorea, which tends to be really random and can look like dancing. Dr Berkowitz: That's very helpful. So, once you've decided the patient has chorea, what's your framework for thinking about the differential diagnosis of the cause of the patient's chorea? Dr Moore: Well, that could be really challenging. The differential for chorea is very broad, and so the two things that I tend to use are age of the patient and acuity of onset. And so, if you're thinking about acute onset of chorea, you're really looking at a structural lesion like a stroke or a systemic issue like infection, hyperglycemia, etc. Where a gradually progressive chorea tends to be genetic in nature. When you're thinking about the difference between a child and an adult, the most common cause of chorea in a child is Sydenham's chorea. And actually, the most common cause of chorea that I tend to see is Parkinson's disease medication. So, if anybody's seen dyskinesia in Parkinson's disease, you've seen chorea. But it's those two things that I'm using, the age of the patient and the acuity. Somewhere in the middle, though---so, if you have subacute onset of chorea---it's important to remember to think about autoimmune conditions or paraneoplastic conditions because these are treatable. Dr Berkowitz: That's very helpful. So, like in any chief concern in neurology, we're using the context like the age and then the time course. And then a number of other helpful points in your article about the distribution of chorea in the body. Any comments you'd like to make about- we have this very helpful table that I thought was very interesting. So, you really get deep into the nuances of chorea and the movement disorder specialist expert level. Are there any aspects of parts of the body affected by chorea or distribution of chorea across the body that help you hone your differential diagnosis? Dr Moore: Certainly. I think where the chorea is located in the body can be helpful, but not as helpful as other conditions where you're localizing a lesion or that sort of thing. Because you can have a systemic cause of chorea that causes a hemichorea; that you can have hyperglycemia causing a hemichorea, or even Sydenham's chorea being a hemichorea. But things that we think about, if the forehead is involved, I would think about Huntington's disease, although this is not pathognomonic. And if it's involving the face or the mouth, you can think about neuroacanthocytosis or, more commonly, tardive dyskinesia. Hemichorea would make me think about some of those systemic issues like hyperglycemia, Sydenham's chorea, those sorts of things, but I would rely more on the historical context and the acuity of presentation than the distribution itself. Dr Berkowitz: Got it. That's very helpful. So those can be helpful features, but not sort of specific for any particular condition. Dr Moore: Exactly. Dr Berkowitz: Yeah, I often see forehead chorea mentioned as sort of specific to Huntington's disease. Since I don't see much Huntington's disease myself, what does forehead chorea look like? What is the forehead doing? How do you recognize that there is chorea of the forehead? It's just sort of hard for me to imagine what it would look like. Dr Moore: It's really tricky. I think seeing the eyebrows go up and down or the brows furrow in an unpredictable way is really what we're looking for. And that can be hard if you're having a conversation. My forehead is certainly animated as we're talking about one of my favorite topics here. One of the tricks that I use with the fellows is to observe the forehead from the side, and there you can see the undulation of the forehead muscles. And that can be helpful as you're looking for these things. I think where it's most helpful to use the forehead is if you're trying to determine if someone with a psychiatric history has tardive dyskinesia or Huntington's disease, because there can be quite a lot of overlap there. And unfortunately, patients can have both conditions. And so, using the forehead movement can be helpful to maybe direct further testing for Huntington's disease. Dr Berkowitz: Oh, wow, that's a very helpful pearl. So, if you see, sort of, diffuse chorea throughout the body and the forehead is involved, to my understanding it may be less specific. But in the context of wondering, is the neuropsychiatric condition and movement disorder related by an underlying cause in the case of seeing orofacial dyskinesias, is the relationship a drug having caused a tardive dyskinesia or is the whole underlying process Huntington's, the absence of forehead might push you a little more towards tardive dyskinesia, presuming there is an appropriate implicated drug and the presence of forehead chorea would really clue you in more to Huntington's. Did I understand that pearl? Dr Moore: That's exactly right, and I'm glad you brought up the point about making sure, if you're considering tardive dyskinesia, that there has been an appropriate drug exposure. Because without that you can't make that diagnosis. Dr Berkowitz: That's a very helpful and interesting pearl, looking at the forehead from the side. That is a movement disorders pearl for sure. Sort of not just looking at the forehead from one angle and trying to figure out what it's doing, but going to look at the patient in profile and trying to sort it out. I love that. Okay. So, based on the differential diagnosis you would have crafted based on whether this is sort of acute, subacute, chronic, the age of the patient, whether it's unilateral, bilateral, which parts of the body. How do you go about the initial evaluation in terms of laboratory testing, imaging, etc.? Dr Moore: Well, certainly in an acute-onset patient, you're going to get a number of labs---and that's listed out for you in the paper---and consider imaging as well, looking for an infarct. One thing our learners will know is that sort of the typical answer to what's the infarct causing hemichorea would be the subthalamic nucleus. But really, those infarcts can be almost anywhere. There are case reports for infarcts in a wide variety of places in the brain leading to hemichorea. So, I think some general blood work and an MRI of the brain is a good place to start. For someone who has a more chronic course of the development of chorea, there are certain labs that I would get---and an MRI, because if you get an MRI and there's heavy metal deposition or other disease, structurally, that indicates a certain condition, that can help you pretty considerably. But otherwise, I'm looking for inflammatory markers, heavy metals, HIV, some general other things that are outlined, to help make sure that I'm not missing something that's treatable before I go down the route of genetic testing. And we may talk about this in a little bit, but if you start out with genetic testing and then you sort of have to back up and do more systemic testing, that can be very disjointed when it comes to good patient care. Dr Berkowitz: That's very helpful. So yeah, if it's acute, obviously this is the most straightforward scenario, acute and unilateral. We're imagining something lesional, as you said, either a stroke or---not sort of sudden, but fast, but not sudden---you might think of another structural lesion. Toxoplasmosis, right, has an affinity for the basal ganglia if you were seeing this in a patient who is immunocompromised. But in a case that, probably as you alluded to, sort of what we would see most commonly in practice, those still relatively rare, sort of subacute to chronic symmetric chorea. There's a long list of tests that are recommended. In your article and in other texts, I've read lupus testing, anti-phospholipid antibodies… but the list is long. I'll refer readers to your article. Out of curiosity as a specialist, how often do you see any of these labs come back revealing any underlying diagnosis in a patient who's otherwise healthy and just has developed chorea and comes to you with that chief concern? I feel like I've sent that mega-workup a few times; I'm obviously a general neurologist, but not nearly as many times as you have been. It's- I can't remember a time where something has come up, maybe an ANA one to forty or something like this that we don't think is relevant. But in your practice, how often do you end up finding a reversible cause in the laboratory testing versus ending up starting to go down the genetic testing route, which we'll talk about in a moment? Dr Moore: It's not common, but it is important that we capture these things. Because for a lot of those laboratory tests, there are treatments that are available, or other health implications if those come back positive. So, the case I think of is a polycythemia vera patient who had diffused subacute onset chorea and was able to be treated, was temporarily managed with medication for her chorea, and as her PV improved, she was able to come off those medications. As I was alluding to before---and I'm sure we'll talk about genetic testing---if you test for HD and it's negative, do you go down the route of additional expensive genetic testing, or do you then circle back and go, oops, I missed this treatable condition? As we talk about genetic testing as well, getting HD testing is a pretty involved process. And so, we want to make sure we are checking all those boxes before we move forward. So, it's not common, but we do catch some treatable conditions, and that's really important not to miss. Dr Berkowitz: That's very interesting. So, you diagnosed that polycythemia vera by blood smear, is that how you make the diagnosis? Dr Moore: Yes. Dr Berkowitz: And is that a once-in-a-career-so-far type of thing, or does that happen time to time? Dr Moore: For me, that's a once-so-far, but I don't doubt that I'll see it again. Dr Berkowitz: Great. And how about lupus and some of these other things we look for in the absence of other systemic features? Have you picked up any of these or heard of colleagues picking up something on laboratory testing? They said, oh, this patient came in for a referral for genetic testing, negative Huntington's disease. And good news, we found polycythemia vera; good news, we found undiagnosed lupus and we reversed it. I'm just curious, epidemiologically, seeing these long lists and not having the subspecialty practice that you do, how often you find a reversible cause like we do for neuropathy all the time, right? Oh, it's diabetes, it's B12---maybe not reversible, but preventing progression---or reversible dementia work up. You get so excited when you find low B12 and you replete the patient's B12, and they get better when they had been concerned they were developing an irreversible condition. How often does one in your subspecialty find a reversible cause on that initial mega-lab screen? Dr Moore: I think it's really uncommon, and maybe the folks that do are caught by someone else that never make it to Huntington's clinic, but I don't tend to see those cases. There are, of course, case reports and well-described in the literature about lupus and movement disorders and things of that nature, but that doesn't come to our clinic on a regular basis for sure. Dr Berkowitz: Got it. That's helpful to hear. Well, we've alluded to genetic testing a number of times now, so let's go ahead and talk about it. A lot of your article focuses on Huntington disease, and I was thinking about---in the course of our medical training in medical school, and then neurology residency, for those of us who don't become movement disorder experts like yourself---we learn a lot about Huntington disease. That's sort of the disease that causes chorea, until we later learned there are a whole number of diseases, not just the reversible causes we've been talking about, but a number of genetic diseases which you expertly reviewing your article. So, what are some of the red flags that suggest to you that a patient with chronically progressive chorea---and whom you're concerned for Huntington's or another genetic cause---what are some things you notice about the history, about the exam, the symptoms, the signs, the syndrome, that suggest to you that, actually, this one looks like it might not turn out to be HD. I think this patient might have something else. And as you have alluded to, how do you approach this? Do you send HD testing, wait for it to come back, and then go forward? Are there genetic panels for certain genetic causes of chorea? Do you skip just a whole exome sequencing, or will you miss some of the trinucleotide repeat conditions? How do you approach this in practice? Dr Moore: I'll try to tackle all that. One thing I will say is that a lot of patients with chorea, regardless of the cause, can look very similar to one another. So, if you're looking at chronic onset chorea, perhaps with some neuropsychiatric features, I'm going to most often think about HD because that's the most common cause. Certainly, as we mentioned before, if there's a lot of tongue protrusion, I would think about the acanthocytic conditions, neurocanthocytosis and McCloud syndrome. But generally in those conditions, we're looking at HD as the most likely cause. Certainly, if there is epilepsy or some other syndromic types of things going on, I may think more broadly. But it's important to know that while HD, as you mentioned, is the cause of chorea, many of our patients will have parkinsonism, tics, dystonia, a whole host of other movement phenomenologies. So, that wouldn't dissuade me from thinking about HD. When we think about the kind of patients that you're describing, upwards of 95% of those people will have Huntington's disease. And the process for genetic testing is fairly involved. The Huntington's Disease Society of America has organized a set of recommendations for providers to go about the process of genetic testing in a safe and supportive way for patients and their families. And so that's referred to in the article because it really is important and was devised by patients and families that are affected by this disease. And so, when we're thinking about genetic testing for HD, if I reveal that you have HD, this potentially affects your children and your parents and your siblings. You can have a lot of implications for the lives and health and finances of your family members. We also know that there is high suicidality in patients with HD, in patients who are at risk for HD; and there's even a higher risk of suicidality in patients who are at risk but test negative for HD. So, we do recommend a supportive environment for these patients and their families. And so, for presymptomatic patients or patients who are at risk and don't have chorea, this involves making sure we have, sort of, our ducks in a row, as it were, when we think about life insurance, and, do you have somebody supportive to be with you through this journey of genetic testing, no matter what the results are? So, oftentimes I'll say to folks, you know, there's this 20-page policy that I encourage you to look at, but there are Huntington's Disease Centers of Excellence across the country that are happy to help you with that process, to make sure that the patients are well supported. This is an individual genetic test because, as you mentioned, it is a CAG repeat disorder. And unfortunately, there is no chorea panel. So, if an HD test comes back negative, what we'll do then is think about what's called the HD phenocopies. As I mentioned before, some of these patients who look like they have HD will have a negative HD test. And so, what do you do then? Well, there's a handful of phenocopies---so, other genetic mutations that cause a very similar presentation. And so, we try to be smart, since there's not a panel, we try to be smart about how we choose which test to do next. So, for instance, there's a condition called DRPLA that is present in an African-American family here in my area, in North Carolina, as well as in Japan. And so, if someone comes from those backgrounds, we may decide that that's the next test that we're going to do. If they are white European descent, we may consider a different genetic test; or if they're sub-Saharan African, we may choose a different one from that. However, even if you do a really thorough job, all those blood tests, all those genetic tests, you will occasionally get patients that you can't find a diagnosis for. And so, it's important to know even when you do a good job, you may still not find the answer. And so, I think trying to do things with this complex of the presentation in a systematic way for yourself so you're not missing something. So, going back to our answer about, how do I look at lupus and polycythemia vera and all of that, to think about it in a systematic way. That when you get to the end and you say, well, I don't have an answer, you know you've tried. Dr Berkowitz: That's very helpful to hear your approach to these challenging scenarios, and also how to approach the potential challenging diagnosis for patients and their families getting this diagnosis, particularly in the presymptomatic phase. And your article touches on this with a lot of nuance and thoughtfulness. So, I encourage our listeners to have a read of that section as well. So, last here, just briefly in our final moments, you discuss in your article the various symptomatic treatments for chorea. We won't have time to go into all the details of all the many treatments you discussed, but just briefly, how do you decide which medication to start in an individual patient with chorea for symptomatic management? What are some of the considerations related to the underlying condition, potential side effect profiles of the particular medications, or any other considerations just broadly, generally, as you think about choosing one of the many medications that can be used to treat chorea? Dr Moore: Certainly. So, there is a group of FDA-approved medications, VMAT2 inhibitors, that we can choose from, or the off-label use of neuroleptics. And so, there's a lot of things that go into that. Some of that is insurance and cost and that sort of thing, and that can play a role. Others are side effects. So, for the VMAT2 inhibitors, they all do have a black box warning from the FDA about suicidality. And so, if a patient does struggle with mental health, has a history of suicidality, psychiatric admissions for that sort of thing, then I would be more cautious about using that medication. All patients are counseled about that, as are their families, to help us give them good support. So, the neuroleptics do not tend to have that side effect and can help with mood as well as the chorea and can be helpful in that way. And some of them, of course, will have beneficial side effects. So, olanzapine may help with appetite, which can be important in this disease. So, the big considerations would be the black box warning and suicidality, as well as, are we trying to just treat chorea or are we treating chorea and neuropsychiatric issues? Dr Berkowitz: Fantastic. Thank you for that overview. And again, for our listeners, there's a lot more detail about all of these medications, how they work, how they're used in different patient populations, their side effects, etc, to be reviewed in your excellent article. Again, today, I've been interviewing Dr Kathryn Moore about her article on diagnosis and management of Huntington's disease in chorea, which appears in the August 2025 Continuum issue on movement disorders. Be sure to check out Continuum Audio episodes from this and other issues. And thank you so much to our listeners for joining today. And thank you again, Dr Moore. Dr Moore: Thanks for having me. Dr Monteith: This is Dr Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

You can't see it, smell it, or taste it,  but it could be one of the biggest stressors on your body today.   In this episode, I sit down with Nicolas Pineault to explore how non-native EMFs (from Wi-Fi, phones, smart meters, and 5G) impact our biology, our sleep, and our nervous system, and why most people have no idea they're being affected.   We break down what the science really says (and what gets ignored), how EMFs dysregulate your cellular function and mitochondria, and why sensitive individuals are often the canaries in the coal mine for what's happening to all of us.   We also talk about simple, practical ways to reduce EMF exposure at home, the future of safer tech, and how to take control of your environment without living in fear.   If you're serious about upgrading your health, this episode is non-negotiable.   RESOURCES & LINKS: Follow Nicolas: @theemfguyExplore his work + free EMF resources: https://theemfguy.com Check out our previous episode here.   THIS SHOW IS BROUGHT TO YOU BY:   ZEOCHARGE Go to zeolitelabs.com and use code IDEAL10 to save 10% on this powerful, broad-spectrum zeolite binder for daily detox support.   ESSENTIAL ENERGY Visit essentialenergy.solutions and use code IDEAL10 to save 10% on their EMF tech, designed to balance and harmonize your body's natural electromagnetic circuit.   OYSTERMAX Head to marinehealthfoods.com and use code IDEAL10 to save 10% on this ultra-pure oyster extract, rich in zinc, copper, vitamin B12, and naturally occurring iodine.   Follow us on Instagram → @idealdayadam  

Nutrients are far more than supplements on a shelf—they are life-sustaining molecules that determine how well the body ages and resists disease. For years, their importance was overlooked because many studies were poorly designed, failing to consider existing nutrient levels or how vitamins and minerals work together. Strong evidence now shows multivitamins can slow brain aging, omega-3s can extend life expectancy, and shortages of vitamin D, magnesium, and B12 are widespread drivers of inflammation and chronic illness. Knowing and addressing individual deficiencies is critical, as these nutrients power billions of chemical reactions every second and are foundational to vitality and longevity. In this episode, I discuss, along with Dr. Rhonda Patrick and Steve Martocci, why nutrients are essential for a healthy body and how to choose the highest quality supplements. Dr. Rhonda Patrick is a scientist and health educator recognized for her leadership in aging and disease prevention. As the founder of FoundMyFitness, she provides evidence-based insights to a global audience through her website and podcast. On YouTube, she engages millions in in-depth discussions on evidence-based strategies for well-being. Dr. Patrick's focus areas include genetic influences in dietary response, micronutrients, sleep, non-pharmacological approaches to mental well-being, and the surprising and paradoxical benefits of biological stressors such as exercise, heat, cold exposure, and plant phytochemicals. As an associate scientist and board member at the Fatty Acid Research Institute, she advances understanding of omega-3 fatty acids in aging and health. Her research has been published in high-impact journals like Nature Cell Biology, Experimental Gerontology, and FASEB. Steve Martocci is the co-founder and CEO of Suppco, a smart supplement tracking platform helping people take the right supplements with confidence. After years of struggling with his health and hitting 300 pounds, Steve turned to functional medicine and supplements to reclaim his well-being. That personal transformation—and the confusion he faced along the way—inspired him to build Suppco. Suppco helps users track what they're taking, avoid unnecessary or low-quality products, and personalize their supplement routine with tools like brand TrustScores, protocol guides, and stack analysis. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here: The Nutrient Gaps That Could Be Aging You Faster My Favorite Supplements for Optimal Health & Longevity How to Choose the Right Supplements (and Avoid the Wrong Ones)

Unlock sharper focus and support long-term brain health with Ketone-IQ — clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. In this episode of the Optimal Protein Podcast, I'm joined by Dr. Andy Galpin — world-renowned muscle physiologist, strength coach, and leading expert in human performance optimization. We dive deep into the cutting-edge science of muscle, metabolism, fat loss, and how to train smarter at every stage of life. NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with magnesium and vitamin B12. Get 20% off at puori.com/VANESSA This conversation covers the latest research on muscle fiber types, how to maintain fast-twitch muscle into your 40s and beyond, and why many women are far more predisposed to strength and power than we've been led to believe. Dr. Galpin also shares actionable strategies to break out of fat loss plateaus, reverse chronic dieting, improve metabolic flexibility, and strategically use tools like intermittent fasting, pre-sleep protein, and creatine to maximize fat loss and muscle retention. You'll learn: What actually happens to fat when you lose it (hint: it leaves your body when you exhale!) Why most people are eating way less protein than they think — and how that sabotages recomposition The truth about sarcoplasmic vs. myofibrillar hypertrophy How to train if you're stuck at 1200 calories and not seeing progress The surprising impact of sleep on fat metabolism and why pre-sleep protein may boost your overnight fat burning How to use your circadian rhythm to schedule workouts for maximum performance What Dr. Galpin recommends if your peak energy window is in the late afternoon — including ideal wake-up and bedtimes Whether Pilates, intermittent fasting, or creatine actually work for fat loss and muscle building And how women can use strength training to build muscle, reverse aging, and become “metabolically bulletproof” If you're looking to overcome metabolic resistance, finally see results from your fat loss efforts, and train in a way that respects your biology — this episode is a masterclass in practical, science-backed strategies from one of the top experts in the world. Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide  Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at https://ketogenicgirl.com with the code VANESSA Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

Rabbi Manis Friedman joins me on DEAD Talks to unpack some of life's biggest questions: Why are we here? Why do we fear death? What really happens after we die?From Judaism's view on the afterlife, reincarnation, heaven, and resurrection, to the universal search for meaning and purpose — Rabbi Friedman breaks it all down with wisdom, clarity, and humor.

Is veganism a healthy lifestyle or social cult with nutritional gaps? Decades-long vegan Jessica Wynn weighs in on this Skeptical Sunday!Welcome to Skeptical Sunday, a special edition of The Jordan Harbinger Show where Jordan and a guest break down a topic that you may have never thought about, open things up, and debunk common misconceptions. This time around, we're joined by writer and researcher Jessica Wynn!Full show notes and resources can be found here: jordanharbinger.com/1203On This Week's Skeptical Sunday:There's a myth that it's impossible to properly nourish the human body on a vegan diet — but nutritional planning is crucial for optimizing one's health on any diet. B12 supplementation is essential for vegans, and iron absorption improves when paired with vitamin C. Done wrong, any diet can lead to deficiencies."Junk food veganism" defeats the health purpose of this lifestyle. Oreos and processed fake meats are technically vegan but nutritionally empty. Ultra-processed foods aren't healthy regardless of origin.Factory farming ethics drive many vegans. Animals experience pain, fear, and joy, yet ag-gag laws hide slaughterhouse conditions. Environmental impact includes massive water usage and pollution.True veganism extends beyond diet. Hidden animal products lurk in cosmetics (fish scales in mascara), clothing (leather), and processed foods. Reading labels becomes investigative work.Focus on whole foods regardless of diet. Shop the grocery store perimeter for fresh produce, minimize processed foods, and listen to your body's needs for optimal health and balance.Connect with Jordan on Twitter, Instagram, and YouTube. If you have something you'd like us to tackle here on Skeptical Sunday, drop Jordan a line at jordan@jordanharbinger.com and let him know!Connect with Jessica Wynn at Instagram and Threads, and subscribe to her newsletter: Between the Lines!And if you're still game to support us, please leave a review here — even one sentence helps! Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom!Do you even Reddit, bro? Join us at r/JordanHarbinger!This Episode Is Brought To You By Our Fine Sponsors:Constant Contact: Go to constantcontact.com for more infoBrain.fm: Free for 30 days: brain.fm/jordanThe Cybersecurity Tapes: thecybersecuritytapes.comHomes.com: Find your home: homes.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When was the last time you got quiet enough to hear what your life is already telling you?What powers your best decisions—hustle or quiet? Chef-founder and former actor Vikki Krinsky shares how she turned premonition-level intuition, elite-client kitchen experience, and stubborn resilience into VK Bars, a clean B12 energy bar now landing in luxury hotels—without venture money. From a life-altering choice at 15 to follow her inner signal, to staging in Europe, to cooking for A-listers, to saying “no” to additives and “yes” to athletes, Vikki shows how to stack wins, slow down, and let feelings inform execution. Show Notes00:00 – Who is Vikki? “Fuel” as a life theme; movement, mind, and food as energy.02:00 – Immigrating S. Africa → Canada; early journaling; adversity shaping drive.04:30 – Premonitions as a kid; learning to nurture intuition.07:00 – Pivotal choice at 15: soccer scholarship dreams vs. TV pilot—listening to guidance.10:30 – Industry pressure to get “camera-ready”; shifting into nutrition & training.13:30 – Walking away from acting; backpacking to Paris; invited to stage in elite kitchens.18:00 – Self-taught path, asking for a shot in Swiss & Spanish kitchens.22:00 – Back to LA: Equinox → first celeb client; learning by doing (and owning mistakes).24:00 – Her real edge: empathy + energy with talent under body-image pressure.26:00 – Underpaid → create the VK Method → A-List Appetite food delivery.29:00 – Quiet practices: “staring at walls,” micro-pauses, best-case intention setting.37:00 – “Stack the wins” as fuel.38:00 – Cooking for Seth MacFarlane; caffeine problem → B12 exploration.40:00 – Prototyping energy bites on set; cold-calling manufacturers.41:00 – Everyone says “don't do it” → she does it anyway; 2020 launch, pause, reformulate.42:00 – Clean label differentiators (rosemary as preservative; no “natural flavors”).43:00 – Door-to-door selling; wins with Four Seasons, Bel-Air, Rosewood; bootstrapping grit.45:00 – New nudge: fueling female athletes with real ingredients. ****Release details for the NEW BOOK. Get your copy of Personal Socrates: Better Questions, Better Life Connect with Marc >>> Website | LinkedIn | Instagram | Drop a review and let me know what resonates with you about the show!Thanks as always for listening and have the best day yet!*A special thanks to MONOS, our official travel partner for Behind the Human! Use MONOSBTH10 at check-out for savings on your next purchase. ✈️*Special props

Language doesn't simply describe reality—it shapes how we see it, how we feel about it, and whether we act. The words we use around climate aren't neutral: they can spark urgency, create fatigue, or open the door to hope.Research shows that familiar terms like climate change and global warming elicit more urgency and willingness to act than newer, heavier terms like climate crisis or climate emergency.In this episode of Food for Thought, I explore which words inspire, which ones backfire, and how choosing clearer, calmer language can move people toward solutions.(A written version of this episode can be found at colleenpatrickgoudreau.com)

Learn how a farmer changed from cotton to sheep to be profitable, share red meat health insights, plus outdoor college programs can earn you college credits, upcoming events & News! Join radio hosts Rebecca Wanner aka ‘BEC' and Jeff ‘Tigger' Erhardt (Tigger & BEC) with the latest in Outdoors & Western Lifestyle News!   NEWS TOPICS: Farming, Outdoors, College, Red Meat, & Upcoming Events Hang on tight - Lots of news and topics covered here... let's ride! Upcoming Events: Rodeo, Horse Sale, Pheasant Hunt Devils Lake Shoot Out Rodeo When: September 5 - 7, 2025 Where: Devils Lake, North Dakota at the Western State Bank Event Center (7823 Hwy 19, Devils Lake, ND). Watch: Saturday night and Sunday afternoon performances will air on https://www.bek.tv/ Stock Contractor & Producer: Abrahamson Rodeo Company PRCA Announcer: Jeff 'Tigger' Erhardt PRCA Music Director: Rebecca Wanner Froelich Legacy Quarter Horses Sale Selling: Blue Roan & Grullo Quarter Horse Fillies & Colts Offering: 2025 Weanlings with Superior Bloodlines, Disposition and Confirmation. Full Details available Here. When: September 20, 2025 Where: Froelich Ranch near Selfridge, North Dakota How To Buy: Bid Live In-person or Online Bidding with DV Auction. Full Details & Catalog Request: https://ranchchannel.com/froelich-legacy-quarter-horses/ Cattlemen's Week Pheasant Hunt by Jorgensen Land & Cattle When: November 20-23, 2025 Where: Ideal, South Dakota Location: Lazy J Grand Lodge at Jorgensen Land & Cattle Information & Contact HERE. Texas Farmer Ditches Cotton for Sheep, Finds Success Grazing on Solar Farms In a dusty field in Texas, Chad Raines is living a new reality — as a shepherd. After four generations of cotton farming, Raines faced years of bad harvests and rising debt, forcing him to rethink his future and to think outside the box. That led him to a growing trend called solar grazing, where farmers rent out sheep to keep vegetation in check at solar farms. Raines now works with Enel North America, helping manage one of the largest solar farms in the U.S., near Waco. The sheep are the perfect lawn mowers, working in all conditions, day or night, even when it's muddy or rainy. While small farms across the country struggle—40% operated at a loss last year—Raines has found success. By grazing 6,000 sheep across 20,000 acres, he turned a profit of nearly $300,000, compared to a loss of $200,000 had he stuck with cotton. It's a profitable venture that also supports his family's future, as his sons are set to join the business. From struggling farmer to thriving shepherd, Raines is a prime example of adapting to change in the world of agriculture. Reference: https://www.cbsnews.com/news/solar-farm-texas-sheep-grazing-farming/ New Study Says Red Meat Can Support Mental and Gut Health — In the Right Diet A new study out of South Dakota State University suggests red meat should not be getting a bad rap — at least when it's part of a high-quality diet. Researchers looked at data from nearly 5,000 adults in the American Gut Project and found that people who ate lean red meat within a healthy eating plan had better levels of nutrients that support brain health — things like choline, selenium, vitamin B12, and zinc. They also had greater gut microbial diversity, which is linked to overall well-being. Samitinjaya Dhakal, the lead researcher, says the takeaway isn't to cut out red meat entirely, but to focus on balanced, high-quality diets where lean meat can play a positive role. The study was supported by the National Cattlemen's Beef Association and could help reshape how we think about red meat in healthy eating. University & Colleges Offer Outdoors Courses  Penn State's Aurora Outdoor Orientation Program offers a unique nature experience plus the opportunity to earn 3 General Health & Wellness Credits as a bonus!   Personal Review: Gregory Clarke, Pennsylvania Hear how this parent of a college freshman took part in the program August 2025 in order to get ready for freshman year, have one more outdoors experience, and make new friends! Check out: https://hhd.psu.edu/rptm/aurora Red Lobster - New! Mariner's Seafood Boil In an attempt to bring you back, Red Lobster has added Seafood Boils to the menu! The new Mariner's Seafood Boil offers a Maine lobster tail, a dozen shrimp, snow crab legs, corn and red potatoes. Served in a hot shake-and-serve bag with your choice of flavor. Flavors include Roasted Garlic Butter, Cajun Butter or Old Bay & Parmesan, and YES you can mix or match those flavors plus there's the option to add Extra Spice! Wanting that infamous Cajun Sausage? You're in luck, it can be added. There are various price points depending on location and if feeding for one to the whole family. Just so you know - Red Lobster is not a sponsor, with us living in an area with few if any options for Seafood Boils had me excited to share the news… and am hoping that Tigger gets the hint that I've got a hankering for a shake the bag kinda dive in, get messy meal! OUTDOORS FIELD REPORTS & COMMENTS We want to hear from you! If you have any questions, comments, or stories to share about bighorn sheep, outdoor adventures, or wildlife conservation, don't hesitate to reach out. Call or text us at 305-900-BEND (305-900-2363), or send an email to BendRadioShow@gmail.com. Stay connected by following us on social media at Facebook/Instagram @thebendshow or by subscribing to The Bend Show on YouTube. Visit our website at TheBendShow.com for more exciting content and updates! https://thebendshow.com/ https://www.facebook.com/thebendshow WESTERN LIFESTYLE & THE OUTDOORS Jeff 'Tigger' Erhardt & Rebecca 'BEC' Wanner are passionate news broadcasters who represent the working ranch world, rodeo, and the Western way of life. They are also staunch advocates for the outdoors and wildlife conservation. As outdoorsmen themselves, Tigger and BEC provide valuable insight and education to hunters, adventurers, ranchers, and anyone interested in agriculture and conservation. With a shared love for the outdoors, Tigger & BEC are committed to bringing high-quality beef and wild game from the field to your table. They understand the importance of sharing meals with family, cooking the fruits of your labor, and making memories in the great outdoors. Through their work, they aim to educate and inspire those who appreciate God's Country and life on the land. United by a common mission, Tigger & BEC offer a glimpse into the life beyond the beaten path and down dirt roads. They're here to share knowledge, answer your questions, and join you in your own success story. Adventure awaits around the bend. With The Outdoors, the Western Heritage, Rural America, and Wildlife Conservation at the forefront, Tigger and BEC live this lifestyle every day. To learn more about Tigger & BEC's journey and their passion for the outdoors, visit TiggerandBEC.com. https://tiggerandbec.com/

What if your 60s could feel better than your 20s?   In this episode, I sit down with Ian Clark, founder of Activation Products, who shares his extraordinary journey from life-threatening illness in his 40s to vibrant health and sharp mental clarity well into his 60s, and how you can do the same.   We talk about the biggest health myths holding people back, why you must become the CEO of your own body, and how powerful solutions, like Solaris, can activate the body's repair and detox systems at a cellular level.   If you feel stuck in survival mode, or want to radically shift the way you age, this episode is a masterclass in reclaiming your vitality.   RESOURCES & LINKS: Follow Ian: @ianclarkactivated Follow Activation Products: @activationproducts   THIS SHOW IS BROUGHT TO YOU BY:   ZEOCHARGE Go to zeolitelabs.com and use code IDEAL10 to save 10% on this powerful, broad-spectrum zeolite binder for daily detox support.   ESSENTIAL ENERGY Visit essentialenergy.solutions and use code IDEAL10 to save 10% on their EMF tech, designed to balance and harmonize your body's natural electromagnetic circuit.   OYSTERMAX Head to marinehealthfoods.com and use code IDEAL10 to save 10% on this ultra-pure oyster extract, rich in zinc, copper, vitamin B12, and naturally occurring iodine.   Follow us on Instagram → @idealdayadam

Ricki Lake joins David on DEAD Talks to share her deeply personal journey through grief, resilience, and rediscovering joy. She opens up about losing her husband, the challenges of navigating heartbreak, and finding love again later in life. With candor and warmth, Ricki reflects on her career, her personal struggles, and the life lessons that emerged from loss.If you've ever faced grief or wondered how to rebuild a meaningful life after tragedy, this conversation offers both comfort and inspiration.Support the show for $5:Join the ⁠⁠⁠DEAD Talk Patreon⁠⁠⁠ to support our mission and get episodes early and ad free!MERCH:"Dead Dad Club" & "Dead Mom Club": ⁠⁠⁠Shop Here⁠⁠⁠DISCOUNTS:⁠⁠10% off Neurogum⁠⁠⁠ made with sustainably-sourced natural caffeine, L-theanine, as well as vitamins B6 and B12, which have been scientifically shown to boost attention and enhance focus. ABOUT:DEAD Talks with David Ferrugio engages death a little bit differently. Each new guest shares their experience with grieving or perspective on death in a way that shatters the “don't talk about death” taboo. Grief doesn't end; it evolves. Having lost his father on September 11th when he was 12, he learned the importance of discussion and sharing other people's stories. DEAD Talks Podcast hopes to make it a little easier to talk about grief, loss, death, mourning, trauma, or whatever it may be. You may cry, but you also may laugh. ⁠Follow DEAD Talks Podcast on ⁠⁠⁠YouTube⁠⁠⁠, ⁠⁠⁠Facebook⁠⁠⁠, ⁠⁠⁠Instagram⁠⁠⁠, ⁠⁠⁠TikTok⁠⁠⁠ + ⁠⁠⁠more⁠⁠⁠⁠⁠⁠⁠⁠www.deadtalks.net⁠⁠⁠⁠

Grandpa Bill's Brain Fuel: The Top Supplements Dr. Amen Recommends for a Healthier MindGrandpa Bill here. For the past few days, we've been on a mission to improve our brain health. We've talked about a great workout for the mind, but today, we're going to dive into what to feed it. Dr. Daniel Amen, a man who has looked at more brain scans than almost anyone, teaches us that you can't have a healthy mind without the right fuel. So, let's talk about his top supplement suggestions—the brain-boosting heroes you might want to add to your daily routine.Remember, always talk to your doctor before starting any new supplement. They're your co-pilot on this journey.If you think of your brain as a house, Omega-3s (like DHA and EPA) are the high-quality lumber. They are a core component of your brain cell membranes. Dr. Amen considers them foundational for memory, mood, and overall brain structure.This trio of B vitamins works together to create energy in the brain. They also help clear away a substance that can be harmful to our blood vessels, keeping the pathways clear for good blood flow. Think of them as the team that keeps the lights on in your mind, ensuring your brain has the juice to function optimally.Choline is a key nutrient your body uses to create a messenger for memory called acetylcholine. Having enough choline is like having a reliable mail carrier—it helps ensure that your memory messages get delivered quickly and accurately.You might think these are just for your stomach, but your gut is often called your "second brain." The healthy bacteria in your gut send signals to your mind that can help manage stress and anxiety. A happy gut often means a happier brain!Dr. Amen points to mushrooms like Cordyceps and Reishi. These are known as "adaptogens," meaning they help your body and brain handle stress more effectively. They don't create a buzz; they train your brain to be more resilient, like a personal trainer building strength.These are powerful compounds that fight inflammation throughout your body, including your brain. Inflammation can harm brain cells over time, so Curcumin and Quercetin act like a cleanup crew, reducing swelling and protecting your mind from damage.This one is crucial for everyone! Vitamin D is vital for mood and overall brain health. Studies show that a lack of Vitamin D is common and can be tied to feelings of sadness. Getting enough of this "sunshine vitamin" can make a world of difference.Rounding out the list, Saffron is a great mood booster, while Ginkgo Biloba helps promote healthy blood flow to the brain.So, there you have it, folks. By giving your brain the right fuel, you're not just taking supplements; you're building a healthier, happier you from the inside out.Keep that body and mind moving!1. Omega-3s (The Brain's Building Blocks)2. B12, B6 & Folate (The Power Plant)3. Choline (The Memory Messenger)4. Probiotics (The Gut-Brain Connection)5. "Smart Mushrooms" (Resilience Trainers)6. Curcumin & Quercetin (The Cleanup Crew)7. Vitamin D (The Sunshine Vitamin)8. Saffron & Ginkgo Biloba#supplements,#BrainHealth,#BrainSupplements,#DanielAmen,#HolisticHealth,#WorkoutsForGeriatrics,#WorkoutsForGeriatrics#SilverStreakers,#HealthyAging,#CognitiveHealth,#Wellness,#Nootropics,#GrandpaBill,

If you haven't listened to Part 1 yet, I encourage you to start there—we covered the basics of protein: what it is, how it functions in the body, why plant and animal amino acids are identical, and why the RDA is just the minimum.In Part 2, I talk about what's shifted for me now that I'm at Level 55 (a language reframe I now love for “aging”), and why I had to “level up” when it came to both strength training and protein intake. Here's what I share:* Why my perspective on protein has deepened—not because I'm vegan, but because I'm 55, post-menopausal, and also highly active* The game-changing role of resistance training (and why lifting heavier is essential as we age)* Why peri- and post-menopausal women—and older men—need more protein to counter muscle loss and support bone health* Practical ways to hit daily targets* The results I've experienced since increasing my protein and lifting heavier

Send us a textOur conversation about Black hair takes an unexpected turn when a clip that almost went viral before I turned off the comments to slow down the engagement, showcasing the messy yet necessary path toward healing from texturism and lenthism in our community.• Addressing the fallout when a short TikTok clip from a longer conversation about "long hair for a black woman" sparked cruel comments• Examining how the same content created different reactions across platforms; war on TikTok versus reserved engagement on Instagram• Clarifying that repeating harmful language to examine it is not the same as endorsing it• Challenging the myth that Black women cannot grow long hair; it's a retention problem, not a growth issue• Providing specific medical tests to request if experiencing hair loss (thyroid, iron/ferritin, vitamin D, B12, hormones, cortisol, blood sugar)• Understanding that coily textures have physical properties that make moisture retention more challenging• Offering alternatives for respectful correction: "I hear how that language can sting. Can we unpack why?"• Encouraging description of hair by its properties (texture, density, porosity) rather than perceived valueShare this with a friend who needs the reminder that her hair can thrive, her voice matters, and her words have weight.Support the showAre you a part of our Patreon Community and Family?Join us today and let's continue building and fostering healthier connections with our hair—from the inside out. As a member, you'll get access to bonus episodes, behind-the-scenes content, limited e-books, early access, and a supportive space for real conversations that go beyond the mic.

Episode 2621 - War in Mexico? Anxiety and B12. Abortions wiped out a generation? More weapons to destroy Gaza! Are we going to become batteries to feed AI? Great show today!

Rick & Kelly join you from Palm Desert with birthday wishes for Rick's mom, a conversation about B12, some wild storm surge video from North Carolina during Hurricane Erin, Denise Richards is trying to kick her ex out of their house and a Justin Bieber impersonator fools Las Vegas IN THE NEWS!For ALL THE THINGS KELLY LOVES, CLICK HERE:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://shopmy.us/kellyandrick⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Rick & Kelly are PROUD to be the OFFICIAL LAUNCH PARTNERS with SOULLIFE MINERAL SUPPLEMENTS here in America! Get the Rick & Kelly DOUBLE discount of $20 off per bottle by buying 2 or more bottles & hitting AUTO ORDER at:⁠⁠⁠⁠⁠https://soullife.com/rickandkelly⁠⁠⁠⁠Check out Rick & Kelly's favorite MAKE WELLNESS ingestible peptides HERE:https://boards.com/a/vL3gBe.kypDicRick & Kelly proudly reveal their new DAILY SMASH MERCH WEBSITE is UP!!! Get your Smash hats, mugs, sweats and more at: dailysmashmerch.spiritsale.comFor more info on how to book Kelly, Rick or the two of them for coffee, lunch, dinner or drinks, go to:https://www.fansocial.coRick & Kelly would love for you to join them on Patreon, where they post hour-plus long, commercial free episodes every week, including celebrity interviews, cooking segments and other videos you won't find on their YouTube channel!Sign up for the Rick & Kelly Show on Patreon.com now!⁠⁠ https:// www.patreon.com/rickkellyshow  ⁠⁠#hurricaneerin #flooding #coastalflooding #superstormsandy #newjersey #northcarolina #surge #deniserichards #divorce #eviction #justinbieber #wynn #wynnlasvegas #imposter #xs #huntingtonbeach #beach #sand #ocean #summer #summertime #dailywalk #walking #grounded #cooking #cookingwithkelly #siriusxm #cancelled #farmersmarket #eggs #basket #lawyerup #tiktok #tea #herbaltea #laryngitis #haters #sad #jealous #bicycles #bikes #minerals #peptides #foxnews #newsmax #newsmax2 #theleventhalreport #live #demonstrations #rhoc #kellydodd #cooking #kitchen #newkitchen #badasskitchen #zline #homeimprovements #tile #backsplash #paint #kitchen #remodel #fansocial #kellydodd #kellyleventhal #rickleventhal #make #ingestible #ingestiblepeptides #peptides #kitchen #irondoors #pinkys #beverlyhills #rhobh #realhousewives #patreon #jefflewislive #siriusxm #mulberrystreet #pickleballpartytown⁠⁠⁠⁠⁠

Water isn't just something you drink, it's something you're in constant relationship with.   In this episode, I sit down with Laura Korchulanin, also known as The Water Whisperer, to explore how water serves as a teacher, a healer, and a connector and why reconnecting with its intelligence is one of the most important steps in restoring our personal and planetary health.   Laura shares her journey with hydrosophy (the wisdom of water), the emotional and energetic impact of dehydration, and why most people are drinking water, but not truly hydrating at a cellular level.    We also explore the difference between tap, bottled, structured, and hydrogen-enriched water, and how quantum devices like LumiVitae are reshaping the way we view hydration, vitality, and coherence.   If you've ever felt drawn to the healing power of water, this episode offers a completely new lens to experience it through.   RESOURCES & LINKS: Follow Laura: @water_whisperer_laura Learn more about her work: waterwhisperer.life Explore LumiVitae: @lumivitae_official Use code IDEAL10 at checkout for 10% off LumiVitae THIS SHOW IS BROUGHT TO YOU BY:   ZEOCHARGE Go to zeolitelabs.com and use code IDEAL10 to save 10% on this powerful, broad-spectrum zeolite binder for daily detox support.   ESSENTIAL ENERGY Visit essentialenergy.solutions and use code IDEAL10 to save 10% on their EMF tech, designed to balance and harmonize your body's natural electromagnetic circuit.   OYSTERMAX Head to marinehealthfoods.com and use code IDEAL10 to save 10% on this ultra-pure oyster extract, rich in zinc, copper, vitamin B12, and naturally occurring iodine.   Follow us on Instagram → @idealdayadam  

In this deeply moving episode of DEAD Talks, David Ferrugio speaks with Anita Moorjani, internationally bestselling author and speaker, about her extraordinary near-death experience during end-stage cancer.Anita shares how she slipped into a coma, left her body, and experienced a state of pure love, awareness, and connection — and how this transformed her understanding of life, death, and healing. Within weeks of returning, her cancer was gone.We explore:* What Anita experienced beyond her body during her NDE* How the feeling of unconditional love changed her forever* The connection between fear, illness, and healing* Why she no longer fears death — and what that means for living* Practical wisdom for living fully now, not later

Is Your Thyroid Lab Test Lying to You? Hidden Signs of Cellular Hypothyroidism with Dr. Eric Balcavage | Podcast #461 Dr. Balcavage Website: https://drericbalcavage.com/

This Gene's a Real MTHFR—Here's What It's Doing to Your Body This episode unpacks the powerful effects of the MTHFR gene mutation—on your heart, liver, brain, and mood. Learn how this tiny genetic hiccup can impact energy, detox pathways, mental health, and longevity—and what to do if you've got it.   5 KEY TAKEAWAYS Heart Disease Connection – MTHFR mutations elevate homocysteine, increasing risk for arterial inflammation, stroke, and dementia. Liver Strain – MTHFR dysfunction contributes to fatty liver and reduces the body's ability to detox. Glutathione Production – The gene impacts your ability to make antioxidants like glutathione and NAC, which protect against oxidative stress. Mood & Mental Health – MTHFR affects neurotransmitter production, especially serotonin and dopamine, increasing risk of depression and ADHD. You Need Methyl Donors – Supplements like methylfolate, P-5-P, SAMe, and betaine are crucial to bypass genetic bottlenecks and restore methylation function.   FEATURED PRODUCT Bliss, featuring SAMe and betaine (trimethylglycine), supports healthy methylation by donating methyl groups—essential for mood, energy, and detox. With sublingual delivery for rapid absorption, Bliss is ideal for those with MTHFR mutations needing extra support for neurotransmitter production, glutathione synthesis, and liver detox. A must-have if you struggle with low mood, brain fog, or inflammation. Get it here: https://www.mswnutrition.com/products/bliss   TIMESTAMPS 00:00 START – Welcome to the School of Doza 01:00 – Introducing the MTHFR gene and its reputation 02:00 – Genetic testing and what a consult reveals 03:00 – Homocysteine, inflammation, and heart disease 05:00 – Nitric oxide, artery stiffness, and dementia risk 07:00 – Why everyone should test for MTHFR and homocysteine 08:00 – The liver's overlooked connection to MTHFR 09:30 – How inflammation triggers liver enzymes 11:00 – Why even "normal" genes need lifestyle support 12:00 – Folate (B9) deficiency and its link to depression 13:30 – Personal story: low folate, high homocysteine, and recovery 14:30 – MTHFR, liver enzymes, and antioxidant production 16:00 – Glutathione and NAC: made in the liver, suppressed by MTHFR 18:00 – Methylation, DNA repair, and cancer risk 20:00 – GGT as a liver marker for oxidative stress 21:00 – Neurotransmitters and the B vitamins behind serotonin 22:00 – MTHFR, ADHD, and mental health 23:00 – How Bliss supports brain function and neurotransmitters 25:00 – Methyl donors vs. methylated B12 shots 26:30 – Why Bliss works better for many than other B complexes 27:00 – Research on betaine and SAMe: brain, mood, addiction 30:00 – Methylation and NAD, COMT, and why Bliss helps both 32:00 – Final thoughts: lifestyle can suppress even a “normal” gene   RESOURCES MTHFR Overview: https://www.ncbi.nlm.nih.gov/books/NBK66131/ Homocysteine and Heart Disease: https://pmc.ncbi.nlm.nih.gov/articles/PMC12027316/ GGT, Liver, and Glutathione: https://pmc.ncbi.nlm.nih.gov/articles/PMC2696075/ Antioxidants and Diabetes Risk: https://pubmed.ncbi.nlm.nih.gov/39442756/ Neurotransmitters and Depression: https://pmc.ncbi.nlm.nih.gov/articles/PMC4750636/ Methyl Donors and Mental Health: https://pmc.ncbi.nlm.nih.gov/articles/PMC10556504/ Betaine for Addiction and Mood: https://www.sciencedirect.com/science/article/abs/pii/S0278584624001611  

Discover why the standard B12 test might be missing your deficiency, and learn the better biomarkers that could reveal if brain fog, fatigue, and cognitive decline are actually nutrition-related rather than age-related.In this deep dive with Dr. Martin Warren, Chief Scientific Officer at the Quadrum Institute and leading B12 researcher, we explore why vitamin B12 deficiency is far more common and complex than most people realize. Dr. Warren explains why standard B12 blood tests are unreliable (with only 50/50 accuracy for detecting deficiency), why the current deficiency cutoff of 148 picomolar may be too low, and how homocysteine and methylmalonic acid are better indicators of functional B12 status. He reveals that B12 deficiency can masquerade as normal aging—causing brain fog, fatigue, and cognitive decline—but is often reversible with proper treatment. The discussion covers why plant-based diets create deficiency risks, how absorption changes with age due to intrinsic factor decline, the connection between B12 and brain health (including white matter damage), and practical testing and supplementation strategies. Dr. Warren also makes a compelling case for revolutionizing healthcare through regular micronutrient monitoring rather than waiting for disease symptoms to appear.

Ben Greenfield Fitness: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In this episode, you’ll get to explore the fascinating world of photobiomodulation and cutting-edge light therapy with one of its true innovators, Kris Sweeting. You'll dive deep into the science, application, and surprising real-world stories behind the red, UVA, and UVB light devices that are making waves in health, wellness, and even the celebrity circuit. Whether you’re interested in getting the most from light therapy for your brain, skin, or mitochondria—or you want to geek out over the bleeding edge of biohacking tech—you’ll find a treasure trove of insights in this episode. Full show notes: https://bengreenfieldlife.com/emrpodcast Episode Sponsors: Pique: Pique Teas are where plants and science intersect to produce teas and supplements of unrivaled efficacy, purity, and convenience. Go to Piquelife.com/Ben to get 20% off for life, plus a free starter kit with a rechargeable frother and glass beaker to elevate your ritual. Organifi Green Juice: Reset your body with Organifi Green Juice! With 11 superfoods, 600mg of ashwagandha, and certified organic ingredients, it curbs cravings, supports stress, and fuels your day. Go to organifi.com/Ben for 20% off! Seatopia: Seatopia delivers lab-tested, sushi-grade seafood that’s verified to be mercury-safe and free from detectable microplastics. Frozen at peak freshness, you'll receive the benefits of super nutrients like EPA, DHA, selenium, zinc, and vitamin D. Right now, you can save 15% on your first box and get a FREE 1:1 chef-led cooking class to kick-start your journey to cooking gourmet seafood at home by going to seatopia.fish/ben or by using code BEN at checkout. MOSH: MOSH's signature blend offers a plant-based high-protein bar. They are a great source of vitamin D and an excellent source of vitamin B12. Head to moshlife.com/BEN to save 20% off, plus FREE shipping on either the Best Sellers Trial Pack or the new Plant-Based Trial Pack. Unmatched: Outlier by Unmatched is the world's first pre-workout featuring Paraxanthine instead of caffeine, delivering sustained energy and focus without the crash, plus premium ingredients like Cognizin for cognitive enhancement and NO3-T for incredible muscle pumps. Try it at unmatchedsupps.com/bengreenfield with special bulk discounts: 15% off one, 20% off two, or 25% off three.See omnystudio.com/listener for privacy information.

For decades, U.S. dietary guidelines have linked “protein” with animal products. Even as the visuals evolved—from the “Basic Four” to the Food Pyramid to MyPlate—the message stuck: protein means meat.But protein isn't a food group at all. It's a macronutrient made of amino acids—the building blocks your body uses to build muscle, repair tissue, produce enzymes and hormones, and support immune health. And here's the thing: your body doesn't care if those amino acids come from lentils or chicken. They're identical at the molecular level.So why does animal protein still get the reputation for being “better”? And what does the science actually say about how much protein we need—and from what sources?In this episode, I talk about:* How U.S. dietary guidelines shaped our view of protein — and why many still think “protein” means “meat”* How protein functions in the body, what amino acids are, and why plant and animal amino acids are identical* Why the RDA for protein is a minimum, not necessarily optimal, especially as we age or increase activity* What top plant-based nutrition experts recommend for daily protein intake and how it compares to the RDA* How protein needs change with age, activity level, and life stage* Why I've doubled my own protein intake — and the results I've seenWhether you're in your 20s or your 80s, plant-based or not, active or just getting started, understanding protein is key to thriving long-term. And yes, you can do it 100% with plants.

Kit de resucitación metabólica: caldos, vitaminas B12 y D3, fitoplancton, magnesio y jugos verdes para devolver energía y salud a quienes más lo necesitan

In this episode, you’ll get to explore the fascinating world of photobiomodulation and cutting-edge light therapy with one of its true innovators, Kris Sweeting. You'll dive deep into the science, application, and surprising real-world stories behind the red, UVA, and UVB light devices that are making waves in health, wellness, and even the celebrity circuit. Whether you’re interested in getting the most from light therapy for your brain, skin, or mitochondria—or you want to geek out over the bleeding edge of biohacking tech—you’ll find a treasure trove of insights in this episode. Full show notes: https://bengreenfieldlife.com/emrpodcast Episode Sponsors: Pique: Pique Teas are where plants and science intersect to produce teas and supplements of unrivaled efficacy, purity, and convenience. Go to Piquelife.com/Ben to get 20% off for life, plus a free starter kit with a rechargeable frother and glass beaker to elevate your ritual. Organifi Green Juice: Reset your body with Organifi Green Juice! With 11 superfoods, 600mg of ashwagandha, and certified organic ingredients, it curbs cravings, supports stress, and fuels your day. Go to organifi.com/Ben for 20% off! Seatopia: Seatopia delivers lab-tested, sushi-grade seafood that’s verified to be mercury-safe and free from detectable microplastics. Frozen at peak freshness, you'll receive the benefits of super nutrients like EPA, DHA, selenium, zinc, and vitamin D. Right now, you can save 15% on your first box and get a FREE 1:1 chef-led cooking class to kick-start your journey to cooking gourmet seafood at home by going to seatopia.fish/ben or by using code BEN at checkout. MOSH: MOSH's signature blend offers a plant-based high-protein bar. They are a great source of vitamin D and an excellent source of vitamin B12. Head to moshlife.com/BEN to save 20% off, plus FREE shipping on either the Best Sellers Trial Pack or the new Plant-Based Trial Pack. Unmatched: Outlier by Unmatched is the world's first pre-workout featuring Paraxanthine instead of caffeine, delivering sustained energy and focus without the crash, plus premium ingredients like Cognizin for cognitive enhancement and NO3-T for incredible muscle pumps. Try it at unmatchedsupps.com/bengreenfield with special bulk discounts: 15% off one, 20% off two, or 25% off three.See omnystudio.com/listener for privacy information.

“We would never dream of taking a Ferrari and putting water and sugar and cow feces in the tank and expect it to run. And we wouldn't do that yet. We do it to our bodies every single day of the week. And we expect our bodies to work well, not just to work well, but to perform like race cars. ” Marco Borges brings inspiration and passion to the podcast as he tells us about his own personal healthy habits, practices, and philosophies while encouraging us to create our own. Based in Miami with his wife and four kids, Marco leads a life of example and follows a plant-based diet and lifestyle. Ove the past twenty years, Marco has worked with some of the world's more well-known celebrities, guiding them to live plant-based as well. Having studied physiology and biology, he is a well-balanced nutritionist, personal trainer, and coach. He created the groundbreaking “22 Greenprint Laws” which teaches folks how to eat, exercise, and live in a way that is sustainable for them and the planet.  On today's show we learned about how life changed for Marco during the pandemic, his approach to guiding people into plant-based diets, why examining our own personal habits is important, and how to find our “why” the fuels important change in our lives. He has a can-do and optimistic attitude that can often be rare in today's world, so you'll leave this episode feeling energized and ready to make necessary changes in your own life!   What we discuss in this episode:  Alexandra talks about how she made a mistake when talking about the history of indigenous lands in a previous podcast episode Dotsie asks guests to join her on a 22-day journey to rework her relationship with wine  Good news Marcos received during the pandemic and how his life changed during the past two years How he instructs people to wade into a plant-based diet when it seems very overwhelming to them Why he ended up living a plant-based life and wanting to help others live happy and healthier How his Cuban family reacted to his decision to go 100% plant-based and peruse personal training instead of being a doctor  Why examining our own personal habits can help lead us to the success that we want  How every meal is a chance to choose health or disease  How food addiction starts and continues The importance of bouncing back from mistakes and changing our habits  How to find our “why” that can motivate us to change our lives  Connect with 22 Days Nutrition - https://mealplanner.22daysnutrition.com Use code SWITCH for 25% off your order at MaxinesHeavenly.com Purality B12 Deal: https://puralityhealth.com/liposomal-b12/ to buy one B12 and get one free plus 35% off the rest of Purality's products   Click the link below to support the FISCAL Act https://switch4good.org/fiscal-act/ Share the website and get your resources here https://kidsandmilk.org/ Send us a voice message and ask a question. We want to hear from you! Switch4Good.org/podcast Dairy-Free Swaps Guide: Easy Anti-Inflammatory Meals, Recipes, and Tips https://switch4good.org/dairy-free-swaps-guide SUPPORT SWITCH4GOOD https://switch4good.org/support-us/ ★☆★ JOIN OUR PRIVATE FACEBOOK GROUP ★☆★  https://www.facebook.com/groups/podcastchat ★☆★ SWITCH4GOOD WEBSITE ★☆★ https://switch4good.org/ ★☆★ ONLINE STORE ★☆★ https://shop.switch4good.org/shop/ ★☆★ FOLLOW US ON INSTAGRAM ★☆★ https://www.instagram.com/Switch4Good/ ★☆★ LIKE US ON FACEBOOK ★☆★ https://www.facebook.com/Switch4Good/ ★☆★ FOLLOW US ON TWITTER ★☆★ https://twitter.com/Switch4GoodOrg ★☆★ AMAZON STORE ★☆★ https://www.amazon.com/shop/switch4good ★☆★ DOWNLOAD THE ABILLION APP ★☆★ https://app.abillion.com/users/switch4good

Send us a textThe battle against cognitive decline begins long before memory problems appear. Dr. Holly Thacker delivers a fascinating deep dive into the nutrients and supplements proven to protect your brain as you age, with startling revelations about how women's brains age differently than men's.At the heart of this episode is a treasure trove of practical knowledge about brain-protective nutrients. A newly available over-the-counter supplement called CerefolinNAC Brain Wellness (formerly prescription-only) combines active folate, methylated B12, and NAC to support brain health.Perhaps most fascinating is the discussion of magnesium's profound impact on brain volume – particularly in women. Despite its vital role in over 300 enzymatic systems, nearly half of Americans consume insufficient amounts. Beyond supplements, Dr. Thacker emphasizes the critical role of physical activity, social engagement, and cognitive challenges in maintaining brain health. For anyone concerned about maintaining mental sharpness through midlife and beyond, this episode provides the roadmap you've been searching for.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts Spotify Strength, Energy & Breaking Barriers ft. Smriti Mandhana | Live Your Best Life, UnscriptedInspiring stories & wellness insights from icons to help you live your best life. Listen on: Apple Podcasts SpotifySupport the show

In this episode of The Keto Vegan, I'm picking up where I left off in the last episode — helping you avoid those face-palm moments

In this deeply moving episode of Dead Talks, host David interviews Patricia Oliver, mother of Joaquin Oliver, who lost her son during the Parkland tragedy. Patricia shares her path from grief to advocacy—creating a foundation, launching art-driven campaigns, and supporting other families impacted by school campus violence. Listen as she recounts messages, personal resilience, spiritual healing, and the creation of Change the Ref, a movement inspired by Joaquin's spirit. Links to Patricia Oliver's work:⁠Change The Ref⁠⁠Lush Sonflower Bath Bomb Fund Raising⁠Support the show for $5:Join the ⁠⁠⁠DEAD Talk Patreon⁠⁠⁠ to support our mission and get episodes early and ad free!MERCH:"Dead Dad Club" & "Dead Mom Club": ⁠⁠⁠Shop Here⁠⁠⁠DISCOUNTS:⁠⁠10% off Neurogum⁠⁠⁠ made with sustainably-sourced natural caffeine, L-theanine, as well as vitamins B6 and B12, which have been scientifically shown to boost attention and enhance focus. ABOUT:DEAD Talks with David Ferrugio engages death a little bit differently. Each new guest shares their experience with grieving or perspective on death in a way that shatters the “don't talk about death” taboo. Grief doesn't end; it evolves. Having lost his father on September 11th when he was 12, he learned the importance of discussion and sharing other people's stories. DEAD Talks Podcast hopes to make it a little easier to talk about grief, loss, death, mourning, trauma, or whatever it may be. You may cry, but you also may laugh. ⁠Follow DEAD Talks Podcast on ⁠⁠⁠YouTube⁠⁠⁠, ⁠⁠⁠Facebook⁠⁠⁠, ⁠⁠⁠Instagram⁠⁠⁠, ⁠⁠⁠TikTok⁠⁠⁠ + ⁠⁠⁠more⁠⁠⁠⁠⁠⁠⁠⁠www.deadtalks.net⁠⁠⁠⁠

In this episode we chat with Aleks Rybchinskiy, co-founder of Berski organ meat sticks, about why organ meats are among nature's most nutrient-dense foods and how they can support overall health. Aleks explains the impressive macronutrient and micronutrient profiles of liver, heart, and other organs—rich in vitamin A, vitamin B12, iron, and choline—nutrients essential for energy, mental clarity, fertility, and immune strength. He shares how Berski incorporates organs, primarily beef liver from regeneratively raised cattle, into convenient, flavorful meat sticks, offering an easy way to get ancestral nutrition without relying solely on supplements. The conversation also unpacks the truth behind food labels like “pasture-raised,” “grass-fed,” and “grass-finished,” exposing industry loopholes and emphasizing the importance of asking farmers the right questions to ensure ethical, regenerative sourcing. Beyond nutrition, Aleks weaves in a holistic perspective on health, encouraging listeners to reconnect with ancestral wisdom, simplify their approach to wellness, and embrace foods and practices that truly nourish body and mind.Aleks Rybchinskiy is the co-founder of Primal Fusion Health, specializing in wellness education and primal integration to live well. As a Master CHEK Practitioner, Neurosomatic & Holistic Therapist with over 15 years of clinical experience working with celebrities, pro athletes, and all walks of life, Aleks guides clients and students globally to live in harmony with themselves and others - mentally, physically, emotionally and spiritually.SHOW NOTES:0:40 Welcome to the show!3:38 Aleks Rybchinskiy's bio4:22 Welcome him to the podcast!5:17 Pottenger's Cats study8:03 How animals prefer organ meats10:33 Palate & taste changes12:23 Benefits of organs15:05 Comparison to bioregulators19:13 Micronutrient density of organs21:14 Conventional vs Organic vs Grass-Fed vs Regenerative27:32 Renee's story about Regenerative farms29:35 *MIMIO HEALTH*31:27 Animal feeds35:08 Berski macronutrients & nutrition38:13 Thyroid, airways, kidneys & cortisol44:01 Organ correlations45:47 Eating feedlot animals51:02 Local farmers, chickens & eggs57:55 About Berski!59:59 Vitamin A toxicity1:04:15 His final piece of adviceRESOURCES:EatBerski.com - code: BIOHACKERBABES to save 20%Primal Fusion HealthBodhi Building InstituteMIMIO HEALTH - code: BIOHACKERBABES to save 20%PUORI - code: BIOHACKERBABES to save 20%Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Angela and Dr Jacey Folkers present a bitesize focusing upon the critical role of B vitamins and other supplements in energy production and overall health. They discuss the importance of understanding how B vitamins, particularly B12 in its methylcobalamin form, are essential for red blood cell maturation and energy levels, especially in individuals with genetic mutations like MTHFR KEY TAKEAWAYS: Importance of B Vitamins: B vitamins, particularly B6, B12 (in the form of methylcobalamin), and folate, are crucial for energy production and red blood cell maturation. Impact of Caffeine on B Vitamins: Caffeine acts as a diuretic and stimulant, leading to the depletion of B vitamins in the body Role of CoQ10: CoQ10 is essential for energy production in the body, and its levels can decline with age or due to the use of statin medications Holistic Approach to Health: While supplements can support health, they are not a substitute for a healthy lifestyle TIMESTAMPS AND KEY TOPICS: [00:02:39] Importance of B vitamins for energy. [00:03:48] CoQ10 and energy production. [00:07:49] Oxidative stress and longevity. VALUABLE RESOURCES Make Longevity a Lifestyle — Not by doing more, but by doing what matters. Join a powerful community of women who get you inside Live Younger: Longevity for Women, my brand-new membership designed to help you reverse your biological age with science-backed strategies that fit real life. Founding Member offer is open for a limited time —Learn more here Join The High Performance Health Community Link to the full episode - https://lnk.to/EP315 A BIG thank you to our sponsors who make the show possible: Want to Age in Reverse? Join the Longevity Membership built for Women where Science meets Sisterhood & Soul.  Limited time founding member offer.  Learn more here at Live Younger Timeline: Supercharge your energy and upgrade your mitochondria with Mitopure - go to timeline.com/angela  and enter code ANGELA to save 10% ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. CONTACT DETAILS Instagram Facebook LinkedIn Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast. This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/

Can you perform at your best as a plant-based athlete? Absolutely, but it takes the right plan. In this episode of the High School Athlete Nutrition Podcast, host and sports dietitian Stephanie shares exactly how to stay energized, build muscle, and recover faster without relying on meat. She explains the most common mistakes plant-based athletes make, from not eating enough to missing key nutrients like protein, iron, vitamin B12, and vitamin D. You'll learn easy swaps, smart food pairings, and quick snack ideas to keep your fuel levels high. Whether you're fully vegan, vegetarian, flexitarian, or just adding more plants to your plate, these strategies will help you stay strong and ready for game day. Resources & Links Join the Academy. Your online sports nutrition library for athletes and their parents Free Game Day Nutrition Checklis Join my community! Follow me on Instagram @highschool.athlete.nutritionGot a question or topic idea? Message me here Episode highlights: (1:37) What “plant-based” really means(2:33) The biggest mistake athletes make when going plant-based(2:47) Protein needs and best sources(4:43) Why iron matters and how to boost absorption(6:33) The role of vitamin B12 and D(8:18) Power snack ideas for lasting energy(9:37) Top mistakes to avoid(11:14) The bottom line for fueling on plants

Why is my B6 so high when I only take a small amount of it?Can nocturia be associated with dehydration?Please weigh in on allulose. Is it too good to be true?My husband's hemoglobin is lower than his previous lab test. Is this a cause for concern? 

Reducing food waste Please share your thoughts concerning controversies about the significance of telomere length

Dr. Daina Parent, ND and Dr. Sarah Clarke, DC, IFMCP engage in an informative clinical conversation about all things folate. From whole food forms to folate's influence on epigenetics, they transform complex biochemistry into a clear, easy-to-follow, and engaging conversation with clinical gems. They discuss the relationship between folate, vitamin B12, and homocysteine on mental health, brain function, and cardiovascular health and cover biomarkers to help clinicians properly test patients for deficiencies. Drs Parent and Clarke highlight throughout the episode the importance of consuming a whole foods diet that emphasizes foods high in natural forms of folate to support whole body health. Podcast Summary 2:10 Folate (vitamin B9) overview – why is folate important and what is it's role in the body? 4:30 Methylation: a folate-dependent process – how is methylation connected to epigenetics and overall healthy functions of body systems 7:00 Foods that contain methyl donors for methylation - including turnip greens, collard greens and other leafy greens 9:00 Methylation and aging 10:00 Natural forms of folate vs. synthetic folic acid 15:10 Why folic acid isn't the ideal for everyone 17:45 Plant sources of folate when consumed in a whole foods diet 21:00 Dangers of the SAD Diet (Standard American Diet) and over consumption of fortified foods with folic acid 23:35 How malabsorption of nutrients due to GI conditions can impact levels of folate in the body 25:00 When we need more folate and lifestyle habits and medications that impact absorption of folate 27:58 Folate's role in mental health, mood and cognition – brain health, brain function, and aging 32:10 Folate and it's connection to cardiovascular health and the importance of B12 and folate in creating balanced homocysteine levels 35:27 Golden Chlorella – superfood with folate and vegetarian source of B12 35:58 How to measure homocysteine and other important biomarkers 41:52 The benefits of running a CBC to help determine folate or B12 deficiencies 44:20 Clinical case that demonstrates the need to find the right form of folate and B12 for each person 45:44 Benefits of whole food form of folate and B vitamins

Subtitle: Holistic Prevention and Treatment Approaches for Autism Spectrum Disorder Introduction In this episode of Pediatric Perspectives, Dr. Paul welcomes Dr. James “Neu” Neuenschwander, president of the Medical Academy of Pediatric Special Needs (MAPS). Together, they explore whether autism is preventable and treatable, sharing the latest insights on environmental, nutritional, and biomedical strategies for families seeking answers and hope. Dr. Neuenschwander draws on decades of clinical experience to outline practical steps for both prevention and intervention, emphasizing the importance of individualized care and the power of real food1. Key Points with Time Stamps • 00:00:40 – Dr. Paul introduces the new VAX FACTS book and where to order it. • 00:01:35 – Dr. Paul welcomes Dr. Neuenschwander, highlighting his role with MAPS and his expertise in treating children on the autism spectrum. • 00:02:42 – Dr. Neuenschwander shares his experience, having treated over a thousand children with autism, and discusses the evolving landscape of autism severity and outcomes. • 00:05:24 – Both doctors agree that biomedical interventions—addressing the gut, brain, and immune system—can make a significant difference in most children with autism. • 00:05:52 – Prevention strategies: Dr. Neuenschwander stresses the importance of maternal detoxification, optimal nutrition (methylated B vitamins, folate, iodine, vitamin D), and a non-inflammatory, toxin-free environment before and during pregnancy. • 00:08:17 – Risks of immune activation in pregnancy: Dr. Paul and Dr. Neuenschwander discuss concerns about vaccinating during pregnancy due to the lack of long-term neurodevelopmental safety data and the potential for immune activation. • 00:10:04 – RSV vaccine concerns: Dr. Neuenschwander highlights miscarriage risks associated with the RSV vaccine and the lack of adequate safety studies. • 00:11:41 – MAPS practitioner training: Dr. Neuenschwander explains the MAPS conference structure and the importance of individualized approaches—there is no one-size-fits-all protocol for autism. • 00:15:54 – Core interventions for children on the spectrum: o Start with a gluten-free, casein-free, soy-free, and corn-free diet. o Focus on real, unprocessed foods. o Address gut health and brain inflammation. o Treat cerebral folate deficiency and consider methyl B12 injections. o Detoxify the environment and avoid further toxin exposures. • 00:18:08 – Advanced strategies: o Address gut over

Is your inner critic running the show? What if the voice inside your head isn't even yours—but a residue of trauma, stress, or dysfunction? In this eye-opening episode of Healthy Waves, host Avik dives deep into the science behind cellular healing with Claire Martinsen, CEO of Biobloom Injectables. Claire breaks down the truth about NADH and B12—how these molecules work at the mitochondrial level to support energy, mental clarity, emotional regulation, and trauma recovery. We explore how NADH + B12 injections can outperform oral supplements, support therapy and somatic work, and offer real, bioavailable healing—not just hype. Claire shares her personal journey of transformation, including relief from ADHD symptoms, hormonal imbalances, and chronic fatigue—all by supporting her cells instead of suppressing symptoms. This isn't just about wellness trends—it's molecular repair from the ground up. Whether you're a high achiever on the edge of burnout or someone healing from trauma, this episode offers powerful, science-backed insights for real transformation. ABOUT THE GUEST:Claire Martinsen is the CEO of Biobloom Injectables, a science-driven wellness company focused on bioavailable solutions for mental clarity, energy, and healing. With a background in biology and public health, Claire bridges cutting-edge research with practical application, helping people unlock their potential—cell by cell. KEY TAKEAWAYS: NADH (Nicotinamide Adenine Dinucleotide + Hydrogen) is a stable, bioavailable form that supports cellular energy (ATP production), brain health, and DNA repair. Unlike NAD+, which needs conversion and loses potency through digestion, NADH IM injections bypass the gut and deliver 100% absorption. Combined with methylated B12, NADH boosts dopamine, serotonin, and oxygenation in the brain—enhancing focus, mood, and nervous system resilience. Claire shares how NADH helped with her ADHD, back pain, gluten intolerance, immune response, and hormonal balance—without side effects. Bioavailable supplements like NADH+B12 complement trauma therapy and somatic work by stabilizing the nervous system and accelerating healing. Biobloom Injectables is committed to accessible wellness grounded in science, with transdermal patches and sublingual formats underway. Claire's mission is rooted in loss—creating this work in honor of her best friend who died by suicide. Her goal is to make mental wellness and biological repair available to all.   CONNECT WITH THE GUEST:Claire Martinson is available on all social platforms under @wheretoclaire. Her company, BioBloom Injectables, offers services globally, including in India. Visit her page or reach out via social to learn more about her wellness offerings and research-backed products.  WANT TO BE A GUEST ON HEALTHY MIND, HEALTHY LIFE?DM on PodMatchDM Me Here:https://www.podmatch.com/hostdetailpreview/avik CHECK PODCAST SHOWS & BE A GUEST: Tune to all our 19 podcasts: https://www.podbean.com/podcast-network/healthymindbyavik Subscribe To Newsletter: https://healthymindbyavik.substack.com/ Join Community: https://nas.io/healthymind OUR SERVICES Business Podcast Management - https://ourofferings.healthymindbyavik.com/corporatepodcasting/ Individual Podcast Management - https://ourofferings.healthymindbyavik.com/Podcasting/ Share Your Story With World - https://ourofferings.healthymindbyavik.com/shareyourstory STAY TUNED AND FOLLOW US!Medium - https://medium.com/@contentbyavikYouTube - https://www.youtube.com/@healthymindbyavikInstagram - https://www.instagram.com/healthyminds.pod/Facebook - https://www.facebook.com/podcast.healthymindLinkedIn Page - https://www.linkedin.com/company/healthymindbyavikLinkedIn - https://www.linkedin.com/in/avikchakrabortypodcaster/Twitter - https://twitter.com/podhealthclubPinterest - https://www.pinterest.com/Avikpodhealth/ SHARE YOUR REVIEW Share your Google Review - https://www.podpage.com/bizblend/reviews/new/ Share a video Testimonial - https://famewall.healthymindbyavik.com/ #podmatch #healthymind #healthymindbyavik #NADH #biohacking #mentalhealthpodcast #neuroscience #B12 #healingjourney #traumarecovery #mindbodyconnection #wellnessjourney #selfcare #mitochondria #consciousliving #mentalhealthawareness #podcastlife #newpodcast #trending #youtube #wellbeing #mindfulness #healthandwellnesspodcast #HealthyMindHealthyLife

What happens after we die? In this episode, David sits down with New Testament scholar Dr. Eric Zito to explore the Bible's real teachings on death, heaven, and resurrection.They dive into the misunderstood Christian hope, near-death experiences, the concept of hell, reincarnation debates, and whether mediums align with scripture.Follow Dr. Eric Zito on Instagram: @zeetstagramSupport the show for $5: Join the ⁠⁠DEAD Talk Patreon⁠⁠ to support our mission and get episodes early and ad free!MERCH:"Dead Dad Club" & "Dead Mom Club": ⁠⁠Shop Here⁠⁠DISCOUNTS:⁠10% off Neurogum⁠⁠ made with sustainably-sourced natural caffeine, L-theanine, as well as vitamins B6 and B12, which have been scientifically shown to boost attention and enhance focus. ABOUT: DEAD Talks with David Ferrugio engages death a little bit differently. Each new guest shares their experience with grieving or perspective on death in a way that shatters the “don't talk about death” taboo. Grief doesn't end; it evolves. Having lost his father on September 11th when he was 12, he learned the importance of discussion and sharing other people's stories. DEAD Talks Podcast hopes to make it a little easier to talk about grief, loss, death, mourning, trauma, or whatever it may be. You may cry, but you also may laugh. ⁠Follow DEAD Talks Podcast on ⁠⁠YouTube⁠⁠, ⁠⁠Facebook⁠⁠, ⁠⁠Instagram⁠⁠, ⁠⁠TikTok⁠⁠ + ⁠⁠more⁠⁠⁠⁠⁠⁠www.deadtalks.net⁠⁠⁠

Did you know that a staggering number of individuals are deficient in vitamin B12? If you're constantly battling fatigue, experiencing low moods, or struggling with memory issues, you might just be one of them!Vitamin B12 is a vital nutrient that our bodies can't produce on their own, making it imperative that we take proactive steps to ensure we're getting enough. It plays a pivotal role in red blood cell production, brain function, and heart health, laying the foundation for overall wellness.But here's the catch: over 50% of people harbor a mutation of the MTHFR gene, hindering their ability to reap the benefits of vitamin B12. That's where I come in! In this episode, I'll reveal how you can determine if you carry this mutation and, most importantly, what actionable steps you can take to address it. Don't miss out on this essential information to reclaim your vitality!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Story at-a-glance Research shows vitamin B12 rapidly replenishes adenosine triphosphate (ATP) levels in pancreatic cells, preventing destructive enzyme activation that causes acute pancreatitis inflammation People with naturally higher vitamin B12 levels show significantly lower risk of developing acute pancreatitis, independent of lifestyle factors Vitamin B12 enhances energy metabolism by converting methylmalonyl-CoA to succinyl-CoA, stabilizing cell membranes and containing digestive enzymes properly Early vitamin B12 administration provides greatest protection, with 1,000-2,000 micrograms daily recommended for supplementation or monthly injections for severe deficiency Combine vitamin B12-rich foods like grass fed liver alongside minimal vegetable oil intake and regular exercise to support overall pancreatic health

Heard you've got MTHFR? Don't panic. This episode breaks down what the MTHFR gene mutation really means (and what it doesn't). We cover methylation, detox, B vitamins (especially methylated forms like methylfolate and methyl B12), homocysteine, and functional bloodwork. We explain why MTHFR isn't a diagnosis, why your protocol should start with the gut and minerals, and what to do if your practitioner threw a bunch of supplements at you without a plan. You'll walk away understanding how to support your body with the right order of operations, proper cofactors, and personalized labs. *** Get Your Tickets Now: Use code REVIVAL for $100 discount ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FitMom | UNSTUCK: The Women's Health & Hormone Summit⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ *** Gut & Hormones all messed up? ⁠⁠⁠⁠➡️ Take the quiz⁠⁠⁠⁠ ***

In this episode, you’ll get to explore what it really means to have a healthy gut—and why most gut tests only skim the surface. With the guidance of Dr. Alex Mohr, Director of Microbiomics at Theriome, you’ll move beyond generic advice and start decoding the true complexity of your own microbiome. Whether you're biohacking your way to peak performance or just want to feel better day-to-day, this episode gives you a powerful roadmap for making your gut data work for you, not just overwhelm you. Full show notes: https://bengreenfieldlife.com/theriome Episode Sponsors: Qualia: Qualia NAD+ is clinically proven, in multiple double-blind, placebo-controlled studies, to increase NAD+ levels by an average of 67%. Visit qualialife.com/boundless and use code BOUNDLESS for 15% off your order, backed by a 100-day money-back guarantee. Just Thrive: For a limited time, you can save 20% off a 90-day bottle of Just Thrive Probiotic and Just Calm at justthrivehealth.com/ben with promo code BEN. That’s like getting a month for FREE—take control today with Just Thrive! RoXiva: Experience the world-class RX1 lamp—an immersive, multisensory tool designed to transport you into deeper, expanded states of awareness through meticulously crafted light and sound journeys. Get yours now by going to roXiva.com/ben! Seatopia: Seatopia delivers lab-tested, sushi-grade seafood that’s verified to be mercury-safe and free from detectable microplastics. Frozen at peak freshness, you'll receive the benefits of super nutrients like EPA, DHA, selenium, zinc, and vitamin D. Right now, you can save 15% on your first box and get a FREE 1:1 chef-led cooking class to kick-start your journey to cooking gourmet seafood at home by going to seatopia.fish/ben or by using code BEN at checkout. MOSH: MOSH's signature blend offers a plant-based, high-protein bar that is a great source of vitamin D and an excellent source of vitamin B12. Head to moshlife.com/BEN to save 20% off, plus FREE shipping on either the Best Sellers Trial Pack or the new Plant-Based Trial Pack.See omnystudio.com/listener for privacy information.