Podcasts about b12

To learn more about the Kairo app, visit their website here: https://kairoapp.co/ In this episode, Jon and Adam are joined by sports psychologist Jim Doorley to explore how visualization can improve both the mental and physical sides of golf. Jim explains why effective visualization is really a form of multisensory mental rehearsal, how it can help golfers prepare for pressure, refine movement patterns, and manage anxiety, and why it works best alongside physical practice rather than replacing it. Jon also shares how a structured visualization routine with the Kairo app helped him feel more prepared for a wedge shot that had caused significant anxiety in tournament play—and ultimately helped him execute it under pressure. They also discuss the research behind visualization, common misconceptions, and practical ways golfers can build it into their weekly routine. Thank you to our show sponsors Lagoon Sleep, Momentous, and Ultra Pouches Lagoon Sleep helps you find the right pillow for your sleep position and body type with a quick two-minute quiz, giving you a more personalized setup for better rest and recovery. Their adjustable pillows are trusted by elite athletes and can help with neck support, cooling, and waking up without aches or pains. Sweet Spot listeners can get 15% off by going to ⁠⁠lagoonsleep.com/sweetspot⁠⁠ and using promo code SWEETSPOT. • The supplement industry can be hard to trust, but Momentous is built around quality, transparency, and third-party testing. Every product is NSF Certified for Sport®, tested for contaminants, banned substances, and label accuracy, so you know exactly what you're putting in your body. Get up to 35% off your first order at ⁠livemomentous.com⁠ with promo code SWEETSPOT. • Ultra Pouches are nicotine-free and caffeine-free pouches designed to provide smooth energy, focus, and mental clarity without the usual crash. They're made with ingredients including Enfinity® PX, L-theanine, Alpha GPC, and vitamins B6 and B12, and come in five flavors ranging from Cool Mint to Blue Razz. They're an easy option to keep at your desk, in your gym bag, or anywhere you want a quick boost without nicotine or caffeine. New customers can get 15% off at TakeUltra.com with code SWEETSPOT Learn more about your ad choices. Visit megaphone.fm/adchoices

If you've ever donated to a GoFundMe after reading one heartbreaking Instagram caption... this episode is for you. This week, Chelsea and Iman are joined by bestselling author, speaker, and advocate Molly Burke (@mollyburkeofficial) to unpack The Cult of Charity Scams, where good intentions become the perfect recruiting tool. From fake fundraisers and disaster relief grifts to organizations that promise to change the world while exploiting the people behind the scenes, we're following the money and asking why doing good has become such good business. Molly shares her firsthand experience working for a charity that quickly turned from nonprofit to cult, complete with charismatic leadership, staff housing, company slogans, loyalty tests, and yes... workplace B12 butt shots. So before you Venmo, donate, or click "monthly recurring gift," give this episode a listen. Your wallet may thank you! Subscribe to Sounds Like A Cult on Youtube!Follow us on IG @soundslikeacultpod, @amanda_montell, @reesaronii, @chelseaxcharles, @imanharirikia.  Pre-order Iman's new book, Once in a Timeline, here! Your pre-order helps make more books possible! Thank you to our sponsors! To Save 10% off your first purchase of a website or domain, Head to ⁠⁠⁠⁠⁠⁠⁠⁠https://www.squarespace.com/CULT⁠⁠⁠⁠ If your glasses are overdue for a refresh, now is the time. Use code PODCAST15 for fifteen percent off your first order at ⁠⁠⁠⁠bit.ly/3OdtU5X Learn more about your ad choices. Visit podcastchoices.com/adchoices

Roughly half of the average American's daily calories now come from ultra-processed foods — and cutting them out changes how you feel faster than you'd expect. Nurse Doza breaks down five shifts that show up within weeks: steadier blood sugar and energy, a healing gut, lower inflammation, clearer thinking, and hunger hormones that finally reset. Learn what really separates processed from ultra-processed food, and why just two weeks of whole food can change everything. Featured Product: Boost by MSW Nutrition When you're riding the ultra-processed blood-sugar roller coaster, energy is the first casualty — the mid-afternoon crash, the brain fog, the reach for the next quick fix. Boost is the multivitamin you can actually feel: 2,500 mcg of methylated B12, a full multivitamin plus B-complex, electrolytes, and plant-based antioxidants including S-acetyl-L-glutathione. Clean, slow-release energy from one stick in water — no added sugar, no crash — so real food finally has a fair shot at steadying you out.

Vitamin B12 Deficiency--The “Aging” Symptoms You Shouldn't Ignore: Leyla Muedin, a registered dietitian nutritionist in New York City, discusses vitamin B12 deficiency as a common problem that can mimic normal aging, noting adults need only about two micrograms daily to support red blood cells, nerves, and DNA. She reviews the history of liver treatment for pernicious anemia and explains that deficiency remains common in older adults, vegans/vegetarians, and people with impaired absorption due to low stomach acid, autoimmune gastritis, weight loss surgery, or medications such as metformin and proton pump inhibitors. Symptoms can develop slowly and include fatigue, weakness, shortness of breath, numbness/tingling, poor balance, memory issues, and brain fog; she advises medical evaluation and B12 testing rather than assuming aging or relying on wellness-clinic injections when levels are normal. She emphasizes B12 is primarily in animal foods, so vegans need supplements, and notes broader nutrient shortfalls she sees in vegan clients.

Was ist eigentlich aus Project No Time geworden? Nach der Challenge Roth ziehen Nick und Nils eine ehrliche Bilanz: Aus lockerem Training ohne Zeitdruck wurde in den letzten Wochen doch wieder ein Alltag, der sich um Einheiten, Heat-Training, Ernährung und Regeneration drehte. Die große Frage: Kann eine Langdistanz überhaupt ein Hobby bleiben – oder übernimmt sie zwangsläufig das ganze Leben?Außerdem sprechen die beiden über Perfektionismus und Trainings-Gamification, die Balance zwischen Sport, Familie und Beruf sowie den berüchtigten Ironman Blues nach dem großen Rennen. Warum weniger Training nicht automatisch Formverlust bedeutet, weshalb neue Ziele und lockere Bewegung helfen können – und warum eine Halbdistanz manchmal einfach die bessere Idee ist. Zum Abschluss gibt's die Race-Prediction für den Ironman Lake Placid und die Frage, wie realistisch Freds nächster Schritt in Richtung Kona ist. Werbung: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠PUSHING LIMITS CLUB⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Deine All-in-One Trainingsapp für Triathlon, Radfahren und mehr! Alles, was du für dein Training brauchst – immer griffbereit.

Episode 2857 - In this wide-ranging episode, Ted and Austin Broer connect B12 deficiency mimicking multiple sclerosis, egg price manipulation earning a $3.3 million fine, Sam Neill's vitamin D deficiency cytokine storm death, J.D. Vance's Joe Rogan allegations about Israeli propaganda campaigns, glyphosate's gluten sensitivity connection, alcohol's cortisol and dehydration cycle, and the Vision Zero red light camera initiative into a broadcast that delivers both urgent health science and pointed institutional accountability.

☎️ Book Your COACHING INQUIRY Call: https://calendly.com/d/386-k9q-4cg/coaching-inquiry-call-zoom☎️ Book Your COMPLEMENTARY CONSULTATION and CALORIE CALCULATION Call: https://calendly.com/d/2p8-mxx-dgf/free-consultation-call-zoom⁠⁠⁠⁠⁠⁠➤ B Vitamin Guide: https://www.vitalityoet.com/bvitamins➤ Gallbladder Hormone Connection - What you need to know whether you have one or not | MMP Ep. 312: https://open.spotify.com/episode/78FCAHtbEgmxJJ15d6mvd5?si=QwdLyC4bSkWk9m7VKIuGUw➤ MTHFR, Methylation & Menopause: The Hidden Link Between Genes, Detox, and Fat Loss | MMP Ep. 246: https://open.spotify.com/episode/5zEgHSoV4RfB9xgG5x2kVv?si=rmhhcKhkT7SPFDhA3AzOHwYou eat well, you take your vitamins, and you're still running on empty — and the scale won't move. In this episode, Stephanie breaks down what B vitamins are really doing inside your body. They don't hand you energy; they're the crew that turns the food you're already eating into energy your body can burn. When they're depleted, you feel exhausted and your body gets bad at burning calories — the same problem wearing two faces. And in perimenopause and menopause, that crew gets depleted faster than you can replace it.You'll learn:Why B vitamins sit at the center of both energy and fat lossThe four jobs the B's run: converting food, making stress hormones, steadying blood sugar, and methylationWhy stress, alcohol, caffeine, low stomach acid, PPIs, metformin, and oral contraceptives quietly drain youWhy a “normal” B12 lab can hide a real deficiencyThe exact order to fix it — and why throwing a B-complex at the problem does nothing if you do it backwardsThis episode is educational and not a substitute for individual medical advice. Talk to your provider before changing any medication or starting new supplements.

Beans are cheap, filling, and weirdly controversial, and that's exactly why we wanted bean.supporter on the show. She's a bean recipe developer who's built a whole online identity around getting more people to eat legumes, not by selling perfection, but by telling the truth about what works. We talk about how beans helped her through real-life health issues, why a 30-day only-beans challenge sparked her creativity, and what she learned from watching the internet react to fiber like it's a horror movie.We get into the practical nutrition too: fiber and gut health, why many people feel better when they finally eat enough beans, and what a beans-only approach still misses from a nutrition standpoint (hello, vitamin B12 and fat-soluble vitamins). Then we go deep on recipes, including the difference between “this is a healthier dessert” and “this tastes exactly like cookie dough” and why that distinction matters if you want sustainable eating habits. You'll also hear our takes on bean desserts that genuinely deliver, like chocolate bean cake and black bean brownies, plus savory staples that keep life simple.Finally, we zoom out to bean culture: Berkeley bean-ups in the park, the canned vs dried beans debate, and why premium beans can taste completely different from the mushy stuff that turned you off years ago. If you want budget-friendly protein, high-fiber meal ideas, and a realistic way to eat more plant-based foods without getting preached at, this one's for you. Subscribe, share with a bean skeptic, and leave a review with your most-used bean and the dish you swear by. Support the showYou can find us on social media here:Rob TiktokRob InstagramLiam TiktokLiam Instagram

This week I had my regularly schedule phone-in with syndicated radio host Michael DelGiorno. We discussed nutritional strategies for health as we age.LONGEVITY AND NUTRITION: 7-NUTRIENTS TO PAY ATTENTION TO AS YOU AGE. DR. JOE GALATI EXPLAINS…1. CalciumWhy it's needed: Keeps bones and teeth strong, helps muscles contract, and assists neurotransmitter release. As you age, the body leaches calcium from bones if you don't consume enough.Best Sources: Dairy (yogurt, cheese, milk), canned salmon/sardines with bones, kale, chia seeds, and fortified plant milks.2. Vitamin DWhy it's needed: Promotes calcium absorption and supports immune and brain health. Seniors often spend more time indoors and their skin becomes less efficient at producing Vitamin D from sunlight.Best Sources: Fatty fish (salmon, trout), egg yolks, and fortified foods like orange juice and cereals.3. Vitamin B6Why it's needed: Vital for metabolism and brain health. Older bodies break down B6 more quickly and absorb it less efficiently.Best Sources: Chickpeas (one cup provides over half the daily goal), chicken breast, bananas, and potatoes.4. Vitamin B12Why it's needed: Essential for the nervous system and red blood cell production. Roughly 10-30% of seniors have trouble absorbing B12 from food, often due to lower stomach acid or medications (like Metformin).Best Sources: Beef, seafood, and eggs. Experts recommend seniors get at least half their B12 from fortified foods (like nutritional yeast or cereals) because they are easier to absorb.5. ProteinWhy it's needed: To blunt sarcopenia(the gradual loss of muscle mass and strength). Nearly one-third of seniors do not eat enough protein.Requirements: Aim for 0.45 to 0.54 grams per pound of body weight (approx. 68–81g for a 150lb person).Best Sources: Greek yogurt, eggs, beans, tofu, and lean meats.6. FiberWhy it's needed: To prevent constipation and lower the risk of cardiovascular disease. Most seniors fall well short of the recommended intake.Requirements: Men (51+) need 30g; Women (51+) need 21g daily.Best Sources: Lentils, whole grains, berries, and leafy greens.7. Total Calories (Energy Intake)Why it's needed: Appetite often declines with age, leading to unintended weight loss and weakness.The Approach: If appetite is low, focus on nutrient-dense, high-calorie foods rather than large volumes of food.Best Strategy: Use healthy fats like olive oil, avocados, peanut butter, and full-fat dairy, or drink smoothies with protein powder to ensure energy needs are met.How To Reach Dr. Joe Galati and his Team:For an on-line consultation or press inquiries, contact Teresa Reyes at 713-794-0700Dr. Galati's Newsletter Sign-UpLiver Specialists of TexasGet a Copy of Dr. Galati's BookDr. Galati on FacebookMessage Dr. Galati and his team Hosted on Acast. See acast.com/privacy for more information.

Despite receiving treatment for Hashimoto's disease, do you still experience fatigue, brain fog, hair loss, or iron deficiency? Autoimmune gastritis could be the missing component. In this episode, Dr. Anshul Gupta explores the hidden connection between Hashimoto's thyroiditis and autoimmune gastritis (thyrogastric syndrome), a condition that can silently affect nutrient absorption, vitamin B12 levels, iron status, and overall thyroid health.Learn the warning signs of autoimmune gastritis; the tests you should ask for, including anti-parietal cell antibodies, intrinsic factor antibodies, ferritin, and B12 levels; and discover evidence-based strategies to support gut and immune health.#Hashimotos #AutoimmuneGastritis #ThyroidHealth #VitaminB12 #IronDeficiency #GutHealth #Hypothyroidism #FunctionalMedicine #DrAnshulGupta

Dr. John Gaitanis, a pediatric neurologist, joins Shannon to discuss common misconceptions about ASD and Motor disorders.  Leucovorin and metabolic interventions are discussed.  The jargon of the day is Methylation Cycle. 00:00 Introduction & Guest Preview 02:27 Autism Live Updates, Podcast & Community Resources 06:31 The Mission of Autism Live & Supporting the Autism Community 09:52 Jargon of the Day: What Is the Methylation Cycle? 13:54 Methylation, Detoxification & Autism Explained 16:22 Meet Pediatric Neurologist Dr. John Gaitanis 18:18 Is Autism Really One Condition? Rethinking the Spectrum 22:04 Autism Phenotypes, Brain Regions & Personalized Care 27:46 Medical Bias, Diagnostic Labels & Presuming Intelligence 32:21 Autism, Healthcare Discrimination & Advocacy for Non-Speakers 36:33 What Is MEDMAPS? Root Cause Medicine Explained 37:43 Developmental Regression, Inflammation & Methylation Dysfunction 46:20 Leucovorin, Folate Deficiency & Autism Treatment Options 53:50 Glutathione, B12, Gut Health & Systems Biology Approaches 57:15 Whole-Body Medicine, Brain Health & Final Takeaways

Dr. John Gaitanis, a pediatric neurologist, joins Shannon to discuss common misconceptions about ASD and Motor disorders.  Leucovorin and metabolic interventions are discussed.  The jargon of the day is Methylation Cycle. 00:00 Introduction & Guest Preview 02:27 Autism Live Updates, Podcast & Community Resources 06:31 The Mission of Autism Live & Supporting the Autism Community 09:52 Jargon of the Day: What Is the Methylation Cycle? 13:54 Methylation, Detoxification & Autism Explained 16:22 Meet Pediatric Neurologist Dr. John Gaitanis 18:18 Is Autism Really One Condition? Rethinking the Spectrum 22:04 Autism Phenotypes, Brain Regions & Personalized Care 27:46 Medical Bias, Diagnostic Labels & Presuming Intelligence 32:21 Autism, Healthcare Discrimination & Advocacy for Non-Speakers 36:33 What Is MEDMAPS? Root Cause Medicine Explained 37:43 Developmental Regression, Inflammation & Methylation Dysfunction 46:20 Leucovorin, Folate Deficiency & Autism Treatment Options 53:50 Glutathione, B12, Gut Health & Systems Biology Approaches 57:15 Whole-Body Medicine, Brain Health & Final Takeaways

Does this mean I have a vitamin B12 deficiency?

Metformin is one of the most commonly prescribed medications for type 2 diabetes and prediabetes, but did you know it can increase the risk of vitamin B12 deficiency? In this episode, Dr Jedha explains why this happens, the symptoms to watch for, and when it's worth talking to your doctor about a simple vitamin B12 blood test.You'll also hear two inspiring member stories showing how sustainable nutrition and lifestyle changes helped improve blood sugar, lower A1c, and avoid or stop medication. Whether you're taking metformin or simply want to better understand your treatment options, this episode provides practical, evidence-based insights to help you make informed decisions about your diabetes health.For show notes and resources, please visit: https://Type2DiabetesTalk.comTo share your questions and suggestions, leave us a voice message or email at: https://Type2DiabetesTalk.com/messageExplore our proven programs and services, visit: https://Type2DiabetesTalk.com/programsSubscribe to our free weekly newsletter for podcast updates, valuable nutrition tips and more: https://Type2DiabetesTalk.com/subscribe

Estrogen dominance is the hidden imbalance behind why your PMS, weight gain, and mood swings all hit at the same time — and most doctors never test for it. Nurse Doza breaks down four clinical reasons your cycle goes sideways: inflammation, dysregulated estrogen, your gut microbiome (the estrobolome), and an inflamed liver. Learn how your gut and liver actually regulate estrogen, why birth control isn't the fix, and the daily habits that restore a healthier, calmer cycle. Featured Product: Boost by MSW Nutrition When your hormones go sideways before your period, energy is usually the first thing to crash — the afternoon wall, the brain fog, the "I could nap standing up" fatigue Nurse Doza describes in this episode. Boost is the multivitamin you can actually feel: 2,500 mcg of methylated B12, a full multivitamin plus B-complex, electrolytes, and plant-based antioxidants including S-acetyl-L-glutathione — with a built-in liver detox support blend to help your body do the clearing work we talked about today. Clean, slow-release energy from one stick in water. No sugar, no crash.

Danielle is breaking down five of the biggest things women are told are "normal" that deserve a much closer look. She dives into chronic fatigue, perimenopause, thyroid health, IBS, gut health, painful sex, pelvic floor dysfunction, and why so many women continue struggling despite being told that everything looks fine.   We dive into why a "normal" ferritin, vitamin D, B12, or thyroid result doesn't always mean you're thriving, why comprehensive lab testing matters, and why symptoms should never be ignored simply because they fall within a laboratory reference range.   One of the biggest frustrations Danielle hears every single week is women feeling dismissed by the healthcare system. Whether you're looking for answers about hormone imbalance, perimenopause, thyroid dysfunction, chronic bloating, IBS symptoms, low energy, or painful sex, you deserve a provider who listens, investigates, and is willing to say, "I don't know—let's figure it out together." This episode is about helping you advocate for yourself, ask better questions, and remember that you—not anyone else—are the CEO of your own health.   empoweredmedicine.co consult for empowered medicine  

Check Out BioVitalis Peptides: https://biovitalis.org/ (Use Promo Code: GSD10 for 10% off)   Check Out Jim Brown's Substack Blog: https://substack.com/@forj   *Disclaimer: This NOT medical advice. Please make sure to seek your own medical professional for medical advice.   Questions Asked/Discussed On This Podcast:   Question1 : I just bought DSIP and Pinealon to help with sleep. I'm trying to find a dosing recommendation for using the 2 in conjunction. Thanks guys, LOVE THE PODCAST!   Question 2: Thanks for the great information every week. What do u guys consider healthy fasted blood sugar levels when running HGH , and at what point do you consider coming off and resetting insulin sensitivity? Thank you   Question 3: What did you use gluathione for and when do you think its useful? I used to drink heavily and thinking of adding for liver health/repair   Question4 : Thank you both for all the valuable information. Watch you guys every Sunday. Couple of questions. 1st I just ordered some 5mg PDE 5 capsules and I want to use them to help with enlarged prostate. I read that it really helps improve the weak urinary flow by relaxing the prostate muscle. Doesn't actually shrink the prostate but helps with the flow. I also take finasteride to help shrink the prostate. Any knowledge on this. And question 2 interested in Kisspeptin myself but im on TRT and I heard I does nothing for you if your on TRT. Again their is always various of options. What do you guys think on this subject. Thanks again for all that you guys do. Keep up the great work.

Los tratamientos con agonistas GLP-1 han supuesto un antes y un después en el manejo de la obesidad. Pero, como ocurre con cualquier herramienta terapéutica, no todo consiste en perder peso y, aunque estos fármacos ofrecen muy buenos resultados, también conllevan una gran responsabilidad: evitar perder salud metabólica por el camino.Porque, ¿qué pasa con el músculo? ¿Por qué es tan importante asegurar un adecuado consumo de proteínas? ¿Qué papel juega la fibra cuando comemos menos? ¿Y qué micronutrientes conviene vigilar, como el hierro, la vitamina B12, la vitamina B1, vitamina D o la colina?En este episodio hablamos de la parte del tratamiento de la que menos se habla: cómo conseguir que la pérdida de peso sea, además, una pérdida de grasa… y no de salud. Porque adelgazar no debería significar perder fuerza, funcionalidad ni aumentar el riesgo de déficits nutricionales.Si tú o alguien cercano está siguiendo un tratamiento con un agonista GLP-1, creo que este episodio puede ayudaros a entender cómo acompañarlo desde la fisiología y la evidencia científica para obtener los mejores resultados.Y si, además, quieres profundizar en otros aspectos relacionados con estos tratamientos, te recomiendo escuchar también los episodios 77 y 111, donde encontrarás información complementaria que te ayudará a entender mejor su funcionamiento, sus beneficios y cómo utilizarlos de la forma más segura y eficaz posible.Como siempre digo: saber más para temer menos y elegir mejor.Para mas información ya sabéis que me tenéis en mi instagram @isabelvina dónde te comparto contenido diario Mi TikTok @isabelvinabasEn mi canal de YouTube Canal YoutubeY los suplementos formulados por mi en mi web  Mi web

The Cobalamin is the gateway brain vitamin. Since B12 plays a role in so many foundational processes that power our minds and bodies, people should begin their Biohacking by ensuring they are getting enough of the B vitamins before diving into hardcore Nootropic or pharmaceutical solutions.Being the "King of B Vitamins," there's an abundance of research done on it; over 8000 articles of relevant research are published on PubMed, and over 700 human clinical trials in this century alone. Here we'll break down the recent performance enhancement studies...3:09 The Cobalamins4:44 Scientific research: Recent performance enhancement studies13:54 The Gateway Brain Vitamin 15:02 Energizing Nootropic19:40 Mitochondrial support21:02 Empowering neuroplasticity27:21 Vs Depression29:49 Deficiency32:22 Anti-Aging Vitamin34:19 Cognitive Enhancer35:56 Food Sources38:24 Cyanocobalamin vs Methylcobalamin vs Hydroxocobalamin41:00 Sources44:28 Getting B12 from a multivitamin?47:52 Recommended Daily50:19 Side Effects51:03 B12 misinformation01:00:49 ConclusionRead Meta-Analysis

Are fatigue, brain fog, and low energy really just signs of aging? In this episode, I explore emerging research on vitamin B12 deficiency, why absorption matters just as much as intake, and who may be at greater risk for low B12 levels. Then I revisit one of today's most talked-about supplements, creatine, and explain why it's gaining attention far beyond the fitness world. We'll discuss the evidence behind creatine's benefits for muscle, brain health, recovery, and healthy aging, along with practical tips for choosing a quality supplement and using it safely.Links mentioned during this episode:All about creatine: https://www.thelyonsshare.org/2025/02/04/all-about-creatine-why-its-making-waves-in-the-health-world-and-if-you-should-take-it/B12 release: https://www.sciencedaily.com/releases/2026/06/260623083116.htmFree Initial Consultation: https://p.bttr.to/3a9lfYkJoin our free weekly newsletter: www.thelyonsshare.org/newsletterInstagram: www.instagram.com/thelyonsshareLyons' Share website: www.thelyonsshare.org

Episode 5 - The Real Cause of Autism - It Will Shock You! Folate, B12 and brain health with Professor Edward Quadros - autoantibodies, the FRAT test, folinic acid, autism research and prenatal nutrition explained.Disclaimer: Please note that all information and content on the UK Health Radio Network, all its radio broadcasts and podcasts are provided by the authors, producers, presenters and companies themselves and is only intended as additional information to your general knowledge. As a service to our listeners/readers our programs/content are for general information and entertainment only.  The UK Health Radio Network does not recommend, endorse, or object to the views, products or topics expressed or discussed by show hosts or their guests, authors and interviewees.  We suggest you always consult with your own professional – personal, medical, financial or legal advisor. So please do not delay or disregard any professional – personal, medical, financial or legal advice received due to something you have heard or read on the UK Health Radio Network.

Wie jedes Jahr kommt heute die Campingplatz-Challenge-Roth Edition. Dieses mal mit Stammgast Jan Stratmann. Wir sprechen über sein Hitze Rennen, dem Ironman Frankfurt und mit Jan Orakeln wir, wie das Renne in Roth am Sonntag ausgehen könnte.Werbung: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠PUSHING LIMITS CLUB⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Deine All-in-One Trainingsapp für Triathlon, Radfahren und mehr! Alles, was du für dein Training brauchst – immer griffbereit.

If the words “dementia test” make you picture needles, scary machines, and a verdict you cannot take back, we get it. That fear keeps a lot of families stuck in delay, denial, and quiet panic. From Detroit's Rosa Parks Geriatric Center at Wayne State University, we sit down with practitioners to make dementia screening feel simple, practical, and worth doing sooner than later. We walk through what a real memory screening looks like, including the Mini-Cog: three words, a clock drawing, and a quick check that can become a baseline for your brain health. We also untangle screening versus testing, what happens if the screen shows concern, and why a full evaluation may include paper-and-pencil cognitive tests, depression screening, lab work for reversible causes like thyroid or B12 issues, and brain imaging such as MRI. Dr. Deol also explains newer Alzheimer's blood tests that look at biomarkers like tau, plus the crucial nuance: a positive marker without symptoms is not the same as a dementia diagnosis. From missed bills and medication slip-ups to personality changes, cooking hazards, and driving confusion, we share the real-world signs families notice and why “it's just aging” can be a costly myth. We also name the biggest barriers, including stigma and limited access, and point you toward support like the Alzheimer's Association and your local Area Agency on Aging. If this conversation helps you, subscribe, share it with someone you love, and leave a review so more families find it when they need it most.This is episode 3 of a 3-part series. Many thanks to the Rosa Parks Clinic, Wayne State University and everyone involved in this series. For more information about the A.G.R.E.E.D/GWEP grant, visit: https://agreed.wayne.edu/community-impactExecutive Producer/Host: J Smiles ComedyProducer: Mia Hall Director of Photography/Editor: Annelise Udoye Support the show"Alzheimer's is heavy but we ain't gotta be!"IG: https://www.instagram.com/parentingupFB: https://www.facebook.com/parentingupYT: https://www.youtube.com/@parentingupTEXT  'PODCAST"  to  +1 404 737 1449  - to give J topic ideas, feedback, say hi!Be sure to leave us a review! 

Your body has been talking to you your whole life. The question is whether anyone ever taught you to listen. In this episode, I want to widen the lens on how you read your own body. We have lost so much of the generational knowledge our mothers and grandmothers once passed down, and now we tend to wait until something hurts before we pay attention. But your body speaks in subtleties long before that. I share one of my great loves, Ayurveda, the 5,000-year-old healing system I studied for three years, and its practice of observation called the eightfold examination. What fascinates me most is how closely it aligns with modern functional nutrition's Nutrition Focused Physical Exam. We walk through what your tongue, skin, hair, nails, and eyes may be reflecting about your gut health, your nutrient status, your oxidative stress, and even your blood sugar, backed by research going back nearly 80 years. Here is what matters most. This is not about self-diagnosis. None of these signs are proof of anything on their own. They are invitations to pay attention, not verdicts to fear. My hope is that noticing your body builds confidence instead of anxiety, the quiet confidence of a woman in a loving conversation with her body rather than at war with it. If you take one small thing from this episode, try this. Tomorrow morning, look at your tongue and just notice. Do it for a week. That is the practice.   Resources Mentioned: Work with Laura: https://www.thebreastcancerrecoverycoach.com/health  Download for iPhone:  https://apps.apple.com/us/app/kajabi/id1485646310 Download for Android:  https://play.google.com/store/apps/details?id=kajabi.kajabiapp&hl=en_US Here is the link to the FREE Ayurveda Mini-Course that I talked about in this episode: https://www.thebreastcancerrecoverycoach.com/mybody   Here are the references: Foundational Asif T, Mohiuddin A, Hasan B, Pauly RR. Importance of Thorough Physical Examination: A Lost Art. Cureus. 2017;9(5):e1212. Newton C. The Functional Nutrition-Focused Physical Exam. IFNA Track 3 Module 2. Tongue Jeghers H. Nutrition: the appearance of the tongue as an index of nutritional deficiency. New England Journal of Medicine. 1942;227:221-8. Khayamzadeh M, Najafi S, Sadrolodabaei P, Vakili F, Kharrazi Fard MJ. Determining salivary and serum levels of iron, zinc and vitamin B12 in patients with geographic tongue. J Dent Res Dent Clin Dent Prospects. 2019;13(3):221-226. Chiang CP, Chang JY, Wang YP, Wu YH, Wu YC, Sun A. Atrophic glossitis: Etiology, serum autoantibodies, anemia, hematinic deficiencies, hyperhomocysteinemia, and management. J Formos Med Assoc. 2020;119(4):774-780. Skin Salem I, Ramser A, Isham N, Ghannoum MA. The Gut Microbiome as a Major Regulator of the Gut-Skin Axis. Front Microbiol. 2018;9:1459. Wang X, Li Y, Wu L, et al. Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression. Biomed Pharmacother. 2021;137:111065. Jafferany M, Franca K. Psychodermatology: Basics Concepts. Acta Derm Venereol. 2016;96(217):35-7. Reunala T, Salmi TT, Hervonen K, Kaukinen K, Collin P. Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease. Nutrients. 2018;10(5):602. Stefanadi EC, Dimitrakakis G, Antoniou CK, et al. Metabolic syndrome and the skin: a more than superficial association. Diabetol Metab Syndr. 2018;10:9. Hair O'Connor K, Goldberg LJ. Nutrition and hair. Clin Dermatol. 2021;39(5):809-818. Arck PC, Overall R, Spatz K, et al. Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J. 2006;20(9):1567-9. Zhang B, Ma S, Rachmin I, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577(7792):676-681. Poonia K, Bhalla M. Premature Graying of Hair: A Comprehensive Review and Recent Insights. Indian Dermatol Online J. 2024;15(5):721-731. Nails Singal A, Arora R. Nail as a window of systemic diseases. Indian Dermatol Online J. 2015;6(2):67-74. Cashman MW, Sloan SB. Nutrition and nail disease. Clin Dermatol. 2010;28(4):420-5. Eyes Knapp A. The Eye as a Guide to Latent Nutritional Deficiency Diseases. Bull N Y Acad Med. 1946. Wakamatsu TH, Dogru M, Tsubota K. Tearful relations: oxidative stress, inflammation and eye diseases. Arq Bras Oftalmol. 2008;71(6 Suppl):72-9. Seydou A, Arnould L, Gabrielle PH, et al. Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study. Nutrients. 2022;14(11):2290. Bu Y, Shih KC, Tong L. The ocular surface and diabetes, the other 21st Century epidemic. Exp Eye Res. 2022;220:109099. Rahman A, Yahya K, Ahmed T, Sharif-Ul-Hasan K. Diagnostic value of tear films tests in type 2 diabetes. J Pak Med Assoc. 2007;57(12):577-81. Seifart U, Strempel I. Trockenes Auge und Diabetes mellitus [The dry eye and diabetes mellitus]. Ophthalmologe. 1994;91(2):235-9. Campagnoli LIM, Varesi A, Barbieri A, Marchesi N, Pascale A. Targeting the Gut-Eye Axis: An Emerging Strategy to Face Ocular Diseases. Int J Mol Sci. 2023;24(17):13338. Let's Connect! If this episode helped you breathe a little easier, please share it with a friend or leave a review. Every share helps spread this message of hope, healing, and whole-person wellness.

Ever been mid-sentence and the exact word you need just completely vanishes? If you are in perimenopause, you've likely experienced this deeply disorienting form of brain fog. But despite what you may have been told, you are not losing your mind, and it is not "just stress." In this episode, we break down the real clinical explanations behind perimenopausal cognitive changes. We look at how fluctuating hormones affect your brain, why standard labs often miss the full picture, and how to have a more useful conversation with your doctor so you can get your sharpness back. In This Episode, You Will Learn: How shifting estrogen levels directly impact the parts of your brain responsible for memory, focus, and word retrieval. Why hormones spike and drop erratically during this transition, making a single, standard blood draw mostly useless. Why a "normal" standard thyroid test (TSH) doesn't guarantee your brain cells are actually getting the energy they need. How low iron stores mimic brain fog, and why "not anemic" is not the same thing as having enough iron for optimal brain function. The exact tests to ask for at your next appointment including a full thyroid panel, ferritin, Vitamin D, and B12 to get real answers.   Take the Why Am I So Tired assessment at whyamisotired.hopenaturalhealth.com   For more on Dr. Erin: Join The Hope Circle Community: https://hormonehealingproject.drerinellis.com/communities/groups/the-hope-circle/home?invite=69120d498b7e3f60397656b8 Work with Dr. Erin here: https://p.bttr.to/3E88ps4 Buy Dr. Erin's Supplements here: https://drerinellis.com/shop Get the Period Productivity Planner here: https://www.amazon.com/dp/B0BBYBRT5Q?ref_=pe_3052080_397514860 Download the FREE Menstrual Cycle Nutrition Guide here: https://detox.drerinellis.com/ Watch The Free Video "7 Hormones Affecting Your Weight Loss Goals" here: https://weightloss.drerinellis.com/ Let's Be Friends: Follow Dr. Erin on Instagram: https://www.instagram.com/dr.erinellis/ Follow Dr. Erin on Facebook: https://www.facebook.com/drerinellisnmd Follow Dr. Erin on TikTok: https://www.tiktok.com/@dr.erinellis?lang=en Join the Free Hope Circle Community: https://hormonehealingproject.drerinellis.com/communities/groups/the-hope-circle/home?invite=69120d498b7e3f60397656b8 Bookmark Dr. Erin's Website: www.drerinellis.com Subscribe to Hope Natural Health on YouTube: https://www.youtube.com/channel/UChHYVmNEu5tKu91EATHhEiA Follow Hope Natural Health on FB: https://www.facebook.com/hopenaturalhealth Sign up for Newsletters here: https://booking.hopenaturalhealth.com/widget/form/VUubL7MNYELduwQL8ssI

Broadcast on KSQD, Santa Cruz on 6-18-2026:>/p> Dr. Dawn opens with Virginia Tech research showing yellow fever mosquitoes can learn to associate DEET with blood meals after just four pairings, with over 60% of trained mosquitoes lunging at DEET alone. She emphasizes using DEET at sufficient concentration since under-application could teach mosquitoes a "life lesson" that compromises one of our best protections against malaria, dengue, and Zika. A controversial new theory from the University of Bonn proposes that iron-rich macrophages in the pigeon liver serve as the long-elusive magnetic compass. Pigeons given drugs that wiped out their liver macrophages became completely disoriented when released on a cloudy day, though critics argue the trace iron is too weakly magnetic and birds may have been agitated by the drug itself. A COVID-era crowd-movement study found that in 32 of 33 trials, people preferred to turn counterclockwise regardless of handedness or culture (Spain and Japan). Animals show no such bias, suggesting a uniquely human biochemical asymmetry—Dr. Dawn speculates this may relate to left-hemisphere language centers near the inner ear, and notes racetracks worldwide run counterclockwise. A caller in Ben Lomond reports mouth irritation from FYGG nanohydroxyapatite toothpaste. Dr. Dawn suspects bystander ingredients (flavorings, paste-consistency agents) rather than the hydroxyapatite itself—which acts as remineralizing "grout" filling tiny tooth cracks—and recommends switching to a different fluoride-free brand like Tom's after the caller confirmed reaction on rechallenge. The same caller asks about turmeric liver toxicity. Dr. Dawn explains that reputable companies following good manufacturing practices stay within 5-10% accuracy on dosing, and her recommended dose (one teaspoon turmeric, one-eighth teaspoon black pepper, around 5g daily) stays far below toxic levels. Curcumin inhibits NF-kappa-B, the master switch for inflammatory cascades. An emailer in Bonny Doon asks about treating chemotherapy-induced peripheral neuropathy. Dr. Dawn recommends electrical acupuncture which works more than half the time, combined with methylated B12 (2,000 micrograms daily), methylated folate (1,000 micrograms twice daily), alpha lipoic acid (300mg twice daily, also effective for tinnitus), and acetyl-L-carnitine (1,500mg daily). She also recommends photomodulation devices using 635nm red light with near-infrared. A caller raises magnetic field effects on humans. Dr. Dawn discusses human adaptability, referencing Chernobyl black moths that increased melanin epigenetically and ongoing efforts to upregulate radiation-resistance genes via mRNA for future space travel. The conversation turns to evolution of unique human hair patterns, with Dr. Dawn proposing sexual selection (armpit/pubic hair for pheromones) and neoteny (women's facial smoothness resembling infants triggering protective responses) as explanations. Dr. Dawn responds to a crowdsourced question about why Santa Cruz "makes people weird," attributing it to the area's low penalties for aberrant behavior and high tolerance for nonconformity. She explains how mirroring within small subgroups creates internal conformity even amid outward "weirdness," with sixties counterculture as a foundational influence. For another crowdsourced question on vitamins for women in their mid-twenties, Dr. Dawn recommends prenatal vitamins because they include extra iron for menstruating women plus adequate B vitamins. For those eating standard American diets or in dorms, she suggests B100 complex, 500mg calcium, and vitamin C.

Today on Beating Cancer Daily, Saranne focuses on anemia, an often overlooked but critical topic for cancer patients, survivors, and anyone experiencing persistent fatigue. Drawing from her personal experiences with anemia during both childhood and years of cancer treatment, Saranne combines humor and insight while welcoming cancer expert Jacqui Bryan for a detailed discussion. Together, they unpack what anemia really is, the many types it encompasses, from iron deficiency to those linked with chronic illness and cancer, and what symptoms signal a need for medical attention. With practical strategies for those in active treatment or survivorship, the conversation empowers listeners to become strong advocates for their own health.Jacqui Bryan is a certified nutrition specialist, whole health educator, certified health coach, and registered nurse, celebrated for her multi-decade cancer survivorship and expertise in nutrition and wellness. Having appeared in over 140 episodes, Jacqui is known for translating complex medical issues into actionable advice, supporting both patients and loved ones through every step of the cancer journey."I think anemia is an awesome topic today because it's often overlooked, yet it affects more than 2 billion people worldwide." ~Jacqui Bryan Today on Beating Cancer Daily:·     Anemia is not a single disease but a wide-ranging symptom signaling underlying health issues, especially common during cancer treatment·     More than 2 billion people globally are affected by anemia, including significant numbers of cancer patients and survivors·     There are over 400 types of anemia, most commonly from iron, vitamin B12, or folate deficiency, as well as those linked to chronic diseases or blood loss·     Symptoms go beyond just feeling tired; look for shortness of breath, pale or yellow skin, heart palpitations, dizziness, headaches, and problems with concentration·     Treatments must be personalized; iron supplements help some, but others require B12, folate, transfusions, or addressing chronic inflammation·     Pairing iron-rich foods with vitamin C increases absorption, while coffee, tea, and dairy can inhibit it·     Anemia caused by cancer or cancer therapies often leads to profound, overwhelming fatigue that requires compassion and specific support from loved ones·     Patients are encouraged to keep a symptom journal, communicate proactively with healthcare teams, and advocate for tests and treatments tailored to their specific needs Guest Contact Information:Jacqui Bryan: JacquiBryan.com 2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 148 countries across 7 continents and features over 420+ original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_SuggestionsTo sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

00:00 – 29:39 – JMV opens with his reaction to last night’s severe weather. Does JMV mind the Knicks victory lap after their NBA Finals victory? And what were his thoughts on Jalen Brunson’s comments during the victory parade? 29:40 – 46:15 - Indy Eleven forward Pat Hogan joins the show! Pat and JMV discuss the Eleven postponing last night’s game due to the weather. Pat gives his thoughts on the USA’s win over Paraguay. He previews tomorrow’s match again Australia! 46:16 – 51:25 – JMV wraps up the 1st hour of the show! 51:26 – 1:11:14 – Is JMV vitamin B12 deficient? JMV takes a call from a listener of the show! 1:11:15 – 1:29:24 – Comedian Joe Gatto, formerly of Impractical Jokers, joins the show! Joe and JMV talk about his career in comedy, how soon he knew his accounting degree would not be put to use, and his upcoming comedy shows at Helium! 1:29:25 – 1:36:00 – JMV previews Fever-Dream as the 2nd hour ends! 1:36:01 – 2:01:59 – Mike Chappell from FOX59 and CBS4 joins JMV! Will the Colts give extensions to Jonathan Taylor, Quenton Nelson and others? What options are still out there at wide receiver? 2:02:00 – 2:11:33 – JMV takes more calls from listeners of the show! 2:11:34- 2:15:46 – JMV wraps up the show! Support the show: https://1075thefan.com/the-ride-with-jmv/See omnystudio.com/listener for privacy information.

Most athletes get routine blood work.Very few understand which biomarkers truly matter for performance, recovery, and longevity.In this episode of Find Your Edge, Coach Chris Newport and dietetic intern Emily Qiu break down the special lab values endurance athletes should know about and why they matter.We discuss:• CBC and CMP basics• ApoB and cardiovascular risk• Magnesium and athletic performance• Vitamin B12 and MMA• Homocysteine and longevity• Vitamin D and bone health• Why athletes need personalized interpretation• How biomarker trends help you make smarter decisionsIf you've ever felt like you're doing everything right but still not seeing the results you want, this episode is for you.Because the goal isn't more information.The goal is clarity.Learn more about the Endurance Edge Longevity Lab:https://www.theenduranceedge.com/longevity/Check out the episode here: https://www.theenduranceedge.com/special-lab-values-endurance-athletes-biomarkers Support the show

JUN. 10, 2026God has given you seed to SOW!"The kingdom of heaven is like a mustard seed." Mt 13:31 NIVJesus said: "The kingdom of heaven is like a mustard seed, which a man took and planted in his field. Though it is the smallest of all seeds, yet when it grows, it is the largest of garden plants and becomes a tree, so that the birds come and perch in its branches" (vv. 31-32 NIV). A mustard seed is only two millimeters in diameter and comes in three primary varieties: yellow, black, and white. Within that seed is a remarkable nutritional profile, including vitamins A, B6, B12, C, E, and K. It's also a source of calcium, iron, magnesium, phosphorus, potassium, sodium, and zinc. It has anti-inflammatory and anti-cancer properties. Jesus pointed out that when it's planted, it can grow up and become one of the largest trees in the garden, blessing the birds of the air by providing them with a home. Paul wrote: "Now may He who supplies seed to the sower...multiply the seed you have sown and increase the fruits of your righteousness" (2Co 9:10 NKJV). Who does God give "seed" to? Sowers, not hoarders! What does God do with your seed when you sow it? He multiplies it! The seed you sow can be in the form of time, service, wisdom, money, compassion, etc. And God promises that when you sow, you will reap His blessing."God is able to bless you abundantly, so that in all things at all times, having all that you need, you will abound in every good work" (2Co 9:8 NIV). God has given you seed-sow it!God has given you seed to sow Sowers, not hoardersShare This DevotionalSend us Fan MailSupport the showChanging Lives | Building Strong Family | Impacting Our Community For Jesus Christ!

“What's good for the heart is good for the head.”  Key Links & Resources  Watch the How Not to Die  documentary:  https://nutritionfacts.org/video/how-not-to-die-documentary/  Get How Not to Die  by Dr. Michael Greger: https://amzn.to/49Ffmni   Visit NutritionFacts.org:  https://nutritionfacts.org/  Dr. Greger's Daily Dozen:  https://nutritionfacts.org/daily-dozen/  Lower LDL Cholesterol Naturally with Food:  https://nutritionfacts.org/book/portfolio/  Subscribe to Age Better Cheat Sheet on Substack:  https://barbarahannahgrufferman.substack.com/  How Not to Die Too Soon: Dr. Michael Greger on Food, Cholesterol & Aging Better  In this episode of Age Better,  I'm joined by Dr. Michael Greger, one of the most recognized voices in lifestyle medicine and evidence-based nutrition, and the New York Times bestselling author of How Not to Die, How Not to Diet, and How Not to Age.  We're talking about the new How Not to Die  documentary, created to celebrate the 10th anniversary of his landmark book, and what its message means now — especially for women in their 60s and beyond who want to protect their heart, brain, bones, muscles, energy, and independence.  Dr. Greger shares why food is not just about weight or willpower, but one of the most powerful tools we have to influence how we age. We talk about the connection between artery health and brain health, why cholesterol matters so much, what to do if a whole-food, plant-based diet does not lower LDL enough, and his take on one of the most debated foods in the kitchen: olive oil.  We also get into protein, muscle, bone health, B12, vitamin D, omega-3s, creatine, and why this way of eating does not have to be all-or-nothing.  What You'll Learn in This Episode  Why the message of How Not to Die  may be even more urgent 10 years later  How Dr. Greger's grandmother helped shape his mission as a physician  Why heart health and brain health are deeply connected  What women should understand about cholesterol, LDL, and the Portfolio Diet  Which foods may help support healthier cholesterol levels  Dr. Greger's current thinking on olive oil  How women can get enough protein on a whole-food, plant-based diet  What nutrients deserve special attention, especially B12, vitamin D, and omega-3s  Why resistance training still matters for muscle and strength  How creatine may fit into the conversation around aging and muscle  Why it's never too late to start eating better  The three foods Dr. Greger most wants people to add: berries, dark leafy greens/cruciferous vegetables, and legumes  The three things he suggests cutting back on first: trans fats, processed meats, and sugar-sweetened beverages  As always, talk with your own healthcare provider before making major changes to your diet, medications, or supplements — especially if you have heart disease, high cholesterol, osteoporosis, or other medical concerns.  And I'd love to hear from you. If you have an idea for a future episode or a guest you'd like me to interview, send me a note at  agebetterpodcast@gmail.com.  Please subscribe or follow Age Better  wherever you listen, and don't forget to check out my newsletter, Age Better Cheat Sheet, on Substack for more smart, science-backed tools to help you stay strong, healthy, and independent for the long haul. 

On this episode of Vitality Radio, Jared launches a new series on ancestral nutrition by diving into the world of glandular supplements and organ-based nutrition. From beef liver and heart to spleen, adrenal, and pancreas, Jared explains what glandulars are, why they've become so popular again, and how they've been used historically in both traditional cultures and functional medicine practices. He breaks down the nutrient density of organ meats, the role of peptides and cofactors, and why freeze-dried, New Zealand-sourced organ supplements may offer unique nutritional support for energy, stress resilience, immune health, and overall vitality. Jared also discusses the concept of “like supports like,” the importance of sourcing and processing, and practical guidance for anyone curious about adding glandular supplements to their wellness routine.Organ/Glandular ProductsVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

🧭 REBEL Rundown Click here for Direct Download of the Podcast. 💨 What Is Nitrous Oxide? Nitrous Oxide (N2O) is a colorless, odorless inhaled anesthetic that has been used for centuries, particularly in the surgical world. Mechanistically, it can induce euphoria, anxiolysis, and intoxication via NMDA receptor antagonism.During the late twentieth century, nitrous oxide was increasingly used recreationally due its accessibility and perceived benign nature.The modern day slang term for nitrous oxide is “whippets” – which tends to refer to the canisters that contain this agent and are frequently used as whipped cream foaming agents.Despite the legal nature and benign perception of nitrous, frequent use can lead to lasting and permanent neurologic effects. 🧠 How Nitrous Oxide Causes Toxicity Nitrous oxide toxicity results from its ability to oxidize the cobalt moiety in Vitamin-B12, thus leading to a functional B12 deficiency, despite adequate consumption and absorption.1Functioning B12 is needed as a cofactor for methionine synthase.2 This enzyme has two critical roles:The conversion of 5-methyl tetrahydrofolate to tetrahydrofolate; tetrahydrofolate is essential for the synthesis of our DNA.And the conversion of homocysteine to methionine; methionine is needed to maintain the integrity of the myelin sheath of our axons.As a result, nitrous toxicity leads to: a megaloblastic anemia and demyelination of both the dorsal columns and the lateral corticospinal tracts (also known as subacute combined degeneration). 🚶‍️ Clinical Manifestations of Nitrous Oxide Toxicity These patients will have a combination of both upper and lower motor neuron symptoms due to demyelination of the dorsal columns, lateral corticospinal tracts, and peripheral nerves. As a result, the following may manifest:Dorsal Columns: diminished sense of proprioception, vibration, and fine touch.Lateral Corticospinal Tracts: upgoing plantars, hyperreflexia, weakness of voluntary distal muscle controlPeripheral Nerves: numbness/tingling and weakness in a glove and stocking pattern (symptoms that start initially in the feet and hands that progressively spread proximally to the ankles and wrists)Taking all of this into account, patients may present with difficulty ambulating, positive Romberg sign, dysmetria (difficulty with finger to nose or heel to shin), upgoing Babinski reflex, and decreased strength and sensation in a glove and stocking pattern. 🔍 How to Diagnose Nitrous Oxide Neurotoxicity History is key! As with a lot of pathologies in toxicology, identifying the exposure will expedite management.A thorough neurologic exam will narrow the differential – with a particular focus to fine, peripheral motor and sensory deficits, dysmetria, proprioception, and ability to ambulate.Magnetic resonance imaging of the spine may identify enhancement and/or edema of the dorsal columns, specifically on T2 weight axial imaging – sometimes referred to as the “inverted V” or “inverted rabbit ears appearance.”3Serum B12 concentrations may be normal as the issue is with a functional deficiency as opposed to a vitamin absence. However, patients have elevated concentrations of both homocysteine and methylmalonic acid, both of which are metabolized in the presence of functional B12. 💉 Management of Nitrous Oxide Toxicity First and foremost, cessation of nitrous oxide abuse is crucial to limit/prevent toxicity.While there is no universally agreed upon treatment regimen, supplementation with intramuscular B12 is recommended.Approaches vary from daily or every other day injections until symptoms improve at which point injections can be spaced out to weekly and then monthly.Physical and occupational therapy may be needed depending on the degree of functional debility.It is important to note, that depending of the severity and chronicity of toxicity, some proportion of patients may not fully return to their baseline. 📌 Take-Home Points Though legal and seemingly benign, nitrous oxide abuse can lead to permanent neurologic dysfunction.Nitrous oxide toxicity can affect the dorsal columns, lateral corticospinal tracts, and peripheral nerves.Thus leading to a constellation of both upper and lower motor neuron deficits, particular in a glove and stocking pattern: deficits in proprioception and fine motor skills, positive Romberg, upgoing Babinski, peripheral numbness, tingling, and weakness.Magnetic resonance imaging may identify symmetric high signal intensity in the dorsal columns.Treatment includes B12 supplementation and physical/occupational therapy as needed. 📚 References Long H. Chapter 81. Inhalants. In: Nelson LS, et al. Goldfrank’s Toxicologic Emergencies. 11th ed. New York: McGraw-Hill; 2019Shah K, Murphy C. Nitrous Oxide Toxicity: Case Files of the Carolinas Medical Center Medical Toxicology Fellowship. J Med Toxicol. 2019 Oct;15(4):299-303. doi: 10.1007/s13181-019-00726-x. Epub 2019 Aug 6. PMID: 31388940; PMCID: PMC6825085.Schmitz ZP, Hoffman RS. Magnetic resonance imaging in a patient with nitrous oxide-induced subacute combined degeneration of the spinal cord. Clin Toxicol (Phila). 2023 Nov;61(11):1006-1008. doi: 10.1080/15563650.2023.2286205. Epub 2023 Dec 19. PMID: 38060330. Post Peer Reviewed By: Marco Propersi, DO (Twitter/X: @Marco_propersi), and Mark Ramzy, DO (X: @MRamzyDO) 👤 Associate Editor Anand Swaminathan MD, MPH All Things REBEL EM Meet The Team 🔎 Your Deep-Dive Starts Here REBEL Core Cast – Pediatric Respiratory Emergencies: Beyond Viral Season Welcome to the Rebel Core Content Blog, where we delve ... Pediatrics Read More REBEL Core Cast 143.0–Ventilators Part 3: Oxygenation & Ventilation — Mastering the Balance on the Ventilator When you take the airway, you take the wheel and ... Thoracic and Respiratory Read More REBEL Core Cast 142.0–Ventilators Part 2: Simplifying Mechanical Ventilation – Most Common Ventilator Modes Mechanical ventilation can feel overwhelming, especially when faced with a ... Thoracic and Respiratory Read More REBEL Core Cast 141.0–Ventilators Part 1: Simplifying Mechanical Ventilation — Types of Breathes For many medical residents, the ICU can feel like stepping ... Thoracic and Respiratory Read More REBEL Core Cast 140.0: The Power and Limitations of Intraosseous Lines in Emergency Medicine The sicker the patient, the more likely an IO line ... Procedures and Skills Read More REBEL Core Cast 139.0: Pneumothorax Decompression On this episode of the Rebel Core Cast, Swami takes ... Procedures and Skills Read More Showing Slide 1 of 7 The post REBEL Core Cast—Nitrous Oxide Toxicity: Whippets and Neurologic Injury appeared first on REBEL EM - Emergency Medicine Blog.

A sardinha é um dos peixes mais saudáveis do verão: rica em ómega-3, proteína, vitamina D e B12. A Nutricionista Mariana Chaves explica qual a quantidade certa e como deve vir acompanhada.See omnystudio.com/listener for privacy information.

How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable, and the proven strategies to grow your brain back, protect your memory, and slash your Alzheimer's risk regardless of your genetics. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Majid Fotuhi, a neuroscientist and neurologist who earned his PhD from Johns Hopkins University and his medical degree from Harvard Medical School. He currently serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in clinical practice, teaching, and neuroscience research, Dr. Fotuhi pioneered the Brain Fitness Program, a multidisciplinary approach to cognitive performance and brain vitality at any age that has produced measurable results documented in peer-reviewed journals. He is the author of three books including the bestselling The Invincible Brain and one of the world's leading experts on neuroplasticity, hippocampus growth, and successful aging. If anyone has earned the right to tell you your brain can get better, it is him. Dr. Fotuhi and Dave break down why Alzheimer's is not a single disease but a soup of modifiable problems, why your lab results can show "normal" while your brain is starving, and how the five pillars of brain health connect directly to longevity, mitochondria function, and human performance. They also get into the brain effects of GLP-1s, the therapeutic promise of psychedelics like psilocybin and ketamine, the role of nootropics and supplements like B12, lithium orotate, and CoQ10, and why your VO2 max may be the single most important number for brain aging. . You'll Learn: Why 97% of Alzheimer's cases involve multiple modifiable causes and what to do about each one How to physically grow your hippocampus through exercise, meditation, and nutrition Why "normal" lab ranges are actively harming millions of people and what optimal actually looks like The 7 everyday things that are shrinking your brain right now How stress, loneliness, and isolation cause measurable brain atrophy Which supplements including B12, lithium orotate, CoQ10, and nootropics support long-term brain health Why VO2 max predicts brain aging better than almost any other marker What psychedelics like psilocybin and ketamine actually do to your brain according to a Johns Hopkins neurologist How the APOE4 gene affects Alzheimer's risk and why exercise can erase that risk entirely Why mitochondria health is the foundation of both brain function and longevity Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Pique | Go to Piquelife.com/dave for 20% off. - BodyHealth | Visit BodyHeath.com and use code DAVE20 for 20% off your first purchase Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Majid Fotuhi, Dr. Majid Fotuhi, The Invincible Brain, brain health, cognitive decline, Alzheimer's prevention, hippocampus, neuroplasticity, brain fog, memory loss, APOE4, brain shrinkage, B12 deficiency, lithium orotate, CoQ10, nootropics, VO2 max, mitochondria, longevity, anti-aging, biohacking, brain optimization, sleep optimization, stress reduction, functional medicine, human performance, psilocybin, ketamine, GLP-1, semaglutide, telomeres, BDNF, brain training, cognitive performance Resources: • Learn More About Dr. Fotuhi's Work At: https://drfotuhi.com/ • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:59 – Intro 03:00 – Cannabis & Nicotine 04:15 – Understanding Alzheimer's 05:38 – Five Pillars Explained 07:55 – Best Cognitive Training 09:08 – Brain Size & Growth 12:36 – B12 & Lab Ranges 17:48 – Head-to-Toe Evaluation 24:17 – Sex & Brain Health 25:43 – Loneliness & Isolation 33:59 – ApoE4 Genetics 35:28 – Alzheimer's Declining 48:44 – Lithium & Brain 59:38 – VO2 Max & Fitness 1:06:42 – Psychedelics 1:09:38 – GLP-1s & Brain 1:12:38 – Closing & Action Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dietitians Torwen Eerkens and Aidan Muir discuss the key vitamins and minerals to consider when trying to conceive, including their role in supporting fertility and promoting healthy development during pregnancy. While nutrition is only one piece of the fertility puzzle, ensuring adequate intake of these nutrients through food and, where appropriate, supplements can help optimise fertility and support maternal and infant health. (1:38) - Folate (4:19) - Iron (5:27) - Omega-3s (6:44) - Vitamin D (8:24) - Other Essential nutrients: B12, C, Choline, Selenium, Zinc, and CoQ10 (10:52) - Practical Recommendations   WEBSITE:  https://www.idealnutrition.com.au/ PODCAST:  https://www.idealnutrition.com.au/podcast/ INSTAGRAM:  https://www.instagram.com/idealnutrition__/?hl=en Our dietitians

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

You can build strong bones and muscles as you age without eating meat or dairy foods. Registered dietitian Brenda Davis joins Chuck Carroll on The Exam Room Podcast to explain how a well-planned plant-based diet can support strength, bone health, and independence after 50. Can plant protein really support muscle? What nutrients matter most for preventing osteoporosis and sarcopenia? And how much protein do older adults actually need?

In this episode, Dr. Jockers breaks down the five nutrient deficiencies most closely linked to memory loss, brain fog, and Alzheimer's disease. You'll learn why these deficiencies are more common than most people realize and how they can impact cognitive health long before a diagnosis occurs.   You'll discover the warning signs of low magnesium, vitamin D, and vitamin B12, along with the role each nutrient plays in supporting healthy brain function. The conversation also explores key lab markers that may reveal hidden deficiencies affecting memory, mood, and focus.   You'll also learn how folate and vitamin B6 influence neurotransmitters, inflammation, and long-term cognitive health. Plus, you'll hear practical strategies for identifying nutrient gaps and supporting your brain through targeted nutrition and lifestyle changes.   In This Episode:  00:00 B12 Aging Warning 00:16 Podcast Welcome 04:18 Top Deficiencies Overview 05:33 Magnesium Brain Calm 08:43 Magnesium Labs And Fixes 14:02 Vitamin D, Mood And Labs 18:40 B12 Dementia Mimic 23:20 B12 Causes And Absorption 27:19 B12 Labs Foods Supplements 31:40 Folate Dementia Risk 37:45 Folate Supplements MTHFR 39:04 Vitamin B6 Neurotransmitters 41:54 B6 Labs Foods Dosing 43:46 Wrap Up And Next Steps   If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday. If you're feeling wired, tired, and depleted, it's time to replenish your electrolytes with Relyte from Redmond. Made with Redmond's Real Salt, this clean formula provides essential electrolytes like sodium, potassium, and magnesium without any sugar or artificial ingredients. Perfect for those under stress, fasting, or living an active lifestyle, Relyte helps restore hydration, improve energy, and support mental clarity. Visit RedmondLife.com/DrJockers and use code JOCKERS for 15% off today!   Support your heart, brain, and immune system with Paleovalley's Wild Caught Fish Roe, a whole food source rich in Omega-3s like EPA and DHA. It's more bioavailable and stable than traditional fish oil, offering benefits for cardiovascular health, mood, and brain function. Go to paleovalley.com/jockers for 15% off your order!   Support your gut-hormone balance and curb cravings naturally with Wonder Biotics, a clinically proven, doctor-formulated probiotic featuring Bifidobacterium B420. Feel less bloating and reduce cravings within 3–6 months. Save 10% using code DRJOCKERS10 at wonderbiotics.com   "Red light therapy on the thyroid for 10 minutes a day helped nearly 75% of women reduce or stop their thyroid meds."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Get 15% off at RedmondLife.com/DrJockers using code JOCKERS. Save 15% at Paleovalley.com/Jockers with code JOCKERS. Save 10% using code DRJOCKERS10 at wonderbiotics.com     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

Episode 2829 - In this wide-ranging and practically grounded Monday episode, Ted and Austin Broer connect weight training longevity research, statin alternatives including Berberine and nattokinase, B12 cognitive protection, magnesium's role in vitamin D activation, US military strategic failures in the Middle East, and ashwagandha cortisol management into a broadcast that delivers both urgent health science and pointed geopolitical analysis.

You have done IVF more than once. Maybe twice. Maybe three times. Maybe more. Each cycle they tweaked the protocol. Higher dose. Lower dose. Different stimulation drug. Different trigger. Added growth hormone. Added DHEA. Mini IVF. Dual stim. Each cycle the protocol changed. And now they are telling you donor eggs. Here is the question this episode is about. They changed the protocol every time. Did anyone look at what was already in your body when each of those protocols arrived? That is what this episode is about. The layer underneath every protocol. In this episode: - Protocol vs system: what your clinic was trained to adjust, and what nobody adjusted across any of your cycles - Why the donor egg conversation arrives after the only variable your clinic was trained to address has been exhausted, not after a full review of your body - The thyroid, iron, B12, vitamin D, inflammation, gut, cortisol, mineral, vaginal microbiome, and blood sugar markers that did not change between cycle 1 and cycle 5 - Why we look at ferritin against 80 to 100 going into IVF, not the lab reference of 15 - What a 2024 study in Archives of Gynecology and Obstetrics found about ovarian reserve markers and natural conception — and why donor eggs gets recommended on markers the literature itself does not support If this is the first episode you have landed on in this series, go back and listen to "Told Donor Eggs Are Your Only Option? Ask This First," then "How Long Should I Try With My Own Eggs Before Donor Eggs?" and "The Gut Findings Your Clinic Did Not Look For." This episode builds on all three. ——— WHAT YOUR CLINIC MISSED The full thyroid panel, not just a TSH. The iron panel that flags ferritin against the fertility target. The gut microbiome testing your REI does not order. The inflammatory markers they tell you are normal. And the male side that almost nobody investigates. Email hello@fabfertile.ca, subject line MISSED, and we will send you the guide. ——— FUNCTIONAL FERTILITY SECOND OPINION A free 45-minute call where I review your labs, your history, and your partner's results with you. You leave knowing what your biology has been telling you and what your next decision could be. Email hello@fabfertile.ca, subject line FERTILE, or book here. ——— ABOUT THE HOST I'm Sarah Clark, founder of Fab Fertile and host of Get Pregnant Naturally, a podcast with over one million downloads. My functional fertility team works with couples navigating low AMH and failed IVF, reviewing functional lab results, gut microbiome, food sensitivity, vaginal microbiome, nutrigenomics, HTMA, DUTCH, toxin testing, and bloodwork alongside nervous system work, to help identify patterns that may not have been considered. We work alongside your medical team, not instead of them. Sarah Clark, founder of Fab Fertile, host of Get Pregnant Naturally (1M+ downloads), and author of Fabulously Fertile. ——— If this episode helped, leave a review on Apple Podcasts. It is how other women find this work. ——— TIMESTAMPS 00:00 The Protocol Changed Every Time. Did Anyone Change You? 01:00 Who's Reviewing Your Case at Fab Fertile 02:00 Protocol vs System: The Layer Underneath Every IVF 03:00 What Your Body Brought to Every Cycle 04:30 What the 2024 Research Says About AMH 06:00 The Markers That Did Not Change Between Cycles 07:30 Why Multiple Tests Are Not One Test 09:00 The Donor Egg Recommendation With Half the Data 10:30 The Functional Fertility Second Opinion

This podcast is listener-supported. To receive new posts and support my work, consider becoming a free or paid subscriber.When we think about staying healthy, we naturally focus on daily habits like a balanced diet, exercise, and stress management. But there is a critical, often overlooked window into our body's internal workings that tells us exactly how those efforts are paying off: regular blood work.In this episode, I dive deep into the world of biomarkers and explore why tracking these numbers is the most powerful tool we have for detecting potential health issues before they ever show physical symptoms.I break down what is actually being measured in standard lipid and metabolic panels, debunk common misconceptions about “optimal” cholesterol levels, and look at the real-life numbers from my own recent blood work for reference. Whether you are curious about how a plant-based diet impacts your numbers or want to know which hidden tests you need to request at your next checkup, this episode serves as your comprehensive guide to owning your health.CAMBODIA 2027: Join me on an unforgettable journey from the breathtaking temples of Angkor to the vibrant streets of Phnom Penh. Join us for Culture, Cuisine & Conservation. Enter JOYFULVEGAN when booking to redeem the special offer of a one-on-one or private cooking class with me.In this episode we cover:* Why serious cardiovascular issues can develop silently without physical symptoms, and how early screening acts as a lifesaver* A simple “garbage truck” analogy to easily understand the differing roles of LDL and HDL cholesterol in your bloodstream* What clinical data reveals about the ideal total cholesterol threshold for eliminating heart attack risk* The chemical difference between animal-based saturated fats and plant-based options like coconut oil* The biological differences between Type 1 and Type 2 diabetes, and how to prevent insulin resistance naturally* How to meet your iron requirements effortlessly on a plant-based diet without unnecessary and dangerous supplementation* Key vitamins, minerals, and inflammation markers that are omitted from standard panels but are vital to request* A look at my own recent blood numbers and a personal story regarding hair thinning, perimenopause, zinc, and B12.

Broadcast from KSQD, Santa Cruz on 6-04-2026: A caller with previously normal platelets now bouncing between 40-60 asks whether to accept her doctor's recommendation of high-dose dexamethasone. Dr. Dawn suggests checking homocysteine and methylmalonic acid for hidden B12 issues, getting an ultrasound to rule out splenic sequestration, and confirming actual autoimmune antibody testing before committing to steroids. Researchers invented a fake disease called "Bixonimania" (periorbital hyperpigmentation supposedly caused by blue light) with obvious tells including a fictional Asteria Horizon University and Starfleet Academy acknowledgment. By 2026, AI chatbots were routinely describing it as real, and three Indian researchers even cited the fake preprint in a peer-reviewed paper that was subsequently retracted. A 75-year-old caller asks about intermittent fasting patterns. Dr. Dawn advises against fasting longer than 24 hours after age 75 due to muscle catabolism, and recommends time-restricted eating instead—starting with protein at 10am to prevent muscle breakdown. For rebuilding lost muscle she prescribes resistance bands, 30g protein including 5g branched-chain amino acids before exercise, and total daily protein matching one's age in grams. A male caller with a T-score of -4.0 on DEXA (diagnostic of severe osteoporosis) asks about pulsed electromagnetic frequency therapy for his hip. Dr. Dawn explains bone's piezoelectric properties mean that compression and electrical stimulation both activate osteoblasts. She recommends checking parathyroid hormone (tumors cause silent calcium loss), notes that vitamin D above 10,000 IU daily can paradoxically activate osteoclasts and worsen osteoporosis. She discusses how decades of proton pump inhibitor use cause achlorhydria leading to both B12 deficiency (elevated MCV) and calcium malabsorption. The same caller asks whether AI has genuine empathy after seeing Claude express regret about military use, and Dr. Dawn explains AI is a statistical mirror — the illusion of empathy from frequency-based word selection trained on human text, not genuine feeling. Daraxonrasib, an oral monoclonal drug from Revolution Medicines, doubled survival time in metastatic pancreatic cancer trials from 7 to 13 months, prompting FDA expanded access. Dr. Dawn explains KRAS—the long-elusive target with no binding pockets—was finally tackled using Gregory Verdine's "molecular glue" approach, where small molecules first attach to bystander proteins to create complexes capable of binding KRAS. A high school in San Francisco has seen seven active and 241 latent TB cases since November 2025, with 18% of the school community infected. Dr. Dawn notes California reached a 12-year high of 2,150 TB cases in 2025, and connects the unusually high latent-infection rate to recent Medi-Cal cuts and immigration-related healthcare avoidance. She argues healthcare access for vulnerable populations is a practical disease-prevention measure.

Welcome to this week's Midlife Minute. Today, I'm focusing on all the questions I received about gallbladder health, including HRT-provoking symptoms, supplements that improve gallbladder health, and evidence-based food interventions. IN THIS EPISODE, YOU WILL LEARN: Why the risk of gallstones and gallbladder inflammation increases during the menopause transition How estrogen and progesterone HRT have different effects on gallbladder functioning The differences in risk between transdermal and oral HRT How the progesterone in HRT can cause gallbladder issues in some women What TUDCA is, and how it supports gallbladder health The value of TUDCA for women who have had their gallbladders removed How various nutrients and supplements support bile flow and gallbladder health What can contribute to gallstone formation Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Gallbladder Research: Cabrera D, Arab JP, Arrese M. UDCA, NorUDCA, and TUDCA in liver diseases: a review of their mechanisms of action and clinical applications. Seminars in Liver Disease. 2019;39(4):397–404. doi:10.1055/s-0039-1696799  Vang S, Longley K, Steer CJ, Low WC. The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases. Global Advances in Health and Medicine. 2014;3(3):58–69. doi:10.7453/gahmj.2014.017  Bai M, Yang L, Liao H, et al. Tauroursodeoxycholic acid improves nonalcoholic fatty liver disease by regulating gut microbiota and bile acid metabolism. Journal of Agricultural and Food Chemistry. 2024;72(41):22655–22668. doi:10.1021/acs.jafc.4c04630  Simon JA, Hudes ES. Relation of serum ascorbic acid to serum vitamin B12, serum ferritin, and kidney stones in US adults. *Archives of Internal Medicine.*1999;159(6):619–624. doi:10.1001/archinte.159.6.619  Walcher T, Haenle MM, Kron M, et al. Vitamin C supplement use may protect against gallstones: an observational study on a randomly selected population. BMC Gastroenterology. 2009;9:74. doi:10.1186/1471-230X-9-74  Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Long-term intake of dietary fiber and decreased risk of cholecystectomy in women. American Journal of Gastroenterology. 2004;99(7):1364–1370. doi:10.1111/j.1572-0241.2004.30281.x  Leitzmann MF, Stampfer MJ, Willett WC, Spiegelman D, Colditz GA, Giovannucci EL. Coffee intake is associated with lower risk of symptomatic gallstone disease in women. Gastroenterology. 2002;123(6):1823–1830. doi:10.1053/gast.2002.37085  Moerman CJ, Smeets FW, Kromhout D. Dietary risk factors for clinically diagnosed gallstones in middle-aged men — a 25-year follow-up study. Annals of Epidemiology. 1994;4(3):248–254. doi:10.1016/1047-2797(94)90099-x Association between dietary magnesium intake and gallstones: the mediating role of atherogenic index of plasma. Lipids in Health and Disease. 2024;23(1):82. doi:10.1186/s12944-024-02074-4  Pitt HA, Doty JE, Murphy MM, Schwarz MB. Progesterone alters biliary flow dynamics. Annals of Surgery. 1999;229(2):205–209. doi:10.1097/00000658-199902000-00008

Can topical B12 help relieve itching?The types of doctors to avoidGetting back to basicsA case study of lavender oil helping to relieve itchingYou say you're dairy sensitive but you use whey protein. Please explain.What are your thoughts on a lactose relief patch that is on offer?

Dr. Joel Kahn dives into a groundbreaking Phase 1 trial of Verve 102, a one-time intravenous gene-editing treatment that silences the PCSK9 gene to produce lasting LDL cholesterol reduction. Among 35 participants, the high-dose group saw LDL drop by 62% with mostly mild side effects — promising results, though Phase 2 and 3 trials and 15 years of follow-up still lie ahead. Also covered: updated colorectal cancer screening guidelines now starting at age 45, healthy lifestyle habits cutting mortality risk in cancer survivors by one-third, real-world weight regain data after stopping GLP-1 medications, why your B12 "normal" range may be too low, a blood test that may predict Alzheimer's years in advance, and a longevity preparedness tool from MIT AgeLab. Sponsored by Igennus — visit igennus.com/drkahn for 20% off.

Serotonin does far more than regulate mood — 90% of it is made in your gut, not your brain. In this episode, Nurse Doza breaks down exactly what serotonin does, why so many people are unknowingly depleted, and how to naturally restore levels through gut health, B vitamins, sunlight, and targeted supplementation.   FEATURED PRODUCT Bliss by MSW Nutrition Serotonin production depends on methylation — and if your methylation pathways are sluggish, you can be doing everything right and still come up short. Bliss is a lemon-flavored sublingual powder featuring TMG (trimethylglycine), a powerful methyl donor that directly supports the methylation reactions your body needs to synthesize serotonin and dopamine. As discussed in this episode, the MTHFR gene, B vitamins, and SAMe are all essential cofactors in serotonin production — and Bliss is formulated to address exactly that gap. Just place it on your tongue and let it absorb in seconds. One serving a day is all it takes.

Your clinic told you donor eggs. You walked out wondering how much time you actually have left. Whether waiting six months means missing your window. Whether trying with your own eggs one more time is brave or stupid. The honest answer is longer than your clinic implied. And the window is not your AMH number. In this episode: - Why a 2024 study in Archives of Gynecology and Obstetrics found that ovarian reserve markers like AMH do not significantly predict natural conception in women with regular cycles - What the 90-day window before ovulation actually is, and why the eggs you work with six months from now are not the eggs you are working with today - The inputs your clinic's timeline assumed would not change: mitochondrial function, inflammation, iron, B12, zinc, vitamin D, cortisol patterns, toxic load - The clinical pattern we see over more than a decade of cases: month zero to six is where the picture comes into view, twelve to eighteen months is where it can start to move substantially - Why some pictures do not move, and why that is still a reason to look before you decide If this is the first episode you have landed on in this series, go back and listen to "Told Donor Eggs Are Your Only Option? Ask This First" and then "The Gut Findings Your Clinic Did Not Look For." This episode builds on both. ——— WHAT YOUR CLINIC MISSED The full thyroid panel, not just a TSH. The iron panel that flags ferritin. The gut microbiome testing that your REI does not order. The inflammatory markers no one notices. The male side that almost no one investigates. Email hello@fabfertile.ca, subject line MISSED, and we will send you the guide. ——— FUNCTIONAL FERTILITY SECOND OPINION A free 45-minute call where I review your labs, your history, and your partner's results with you. You leave knowing what your biology has been telling you and what your next decision could be. Email hello@fabfertile.ca, subject line FERTILE, or book here. ——— ABOUT THE HOST Now in its eighth year, Get Pregnant Naturally was one of the first podcasts dedicated to the functional fertility approach for low AMH and failed IVF. Hosted by Sarah Clark, founder of Fab Fertile, author of Fabulously Fertile, and host of a podcast with over one million downloads. Fab Fertile is a functional fertility team that works with couples to review the lab work most fertility clinics do not run: gut microbiome, food sensitivity, vaginal microbiome, nutrigenomics, HTMA, DUTCH, full thyroid panel, the iron panel, and inflammation markers, alongside nervous system work. Each week Sarah brings you what the team sees across more than a decade of cases. Sarah Clark, founder of Fab Fertile, host of Get Pregnant Naturally (1M+ downloads), and author of Fabulously Fertile. ——— If this episode helped, leave a review on Apple Podcasts. It is how other women find this work. ——— TIMESTAMPS 00:00 The Donor Egg Recommendation and the Real Question 01:00 Who's Reviewing Your Case at Fab Fertile 01:30 AMH Is Not the Countdown Clock 03:00 The 90-Day Window Before Ovulation 04:30 What Actually Changes In 90 Days 07:00 The Fab Fertile Method: What We Investigate 08:30 Why Some Cases Do Not Shift 09:30 The Functional Fertility Second Opinion

In this episode of the Hormone Genius Podcast, the hosts sit down with Dr. Marina Suri, an OB-GYN with more than 30 years of experience in restorative reproductive medicine and women's health. Together, they explore a refreshing and hopeful perspective on fertility, longevity, and what women can do naturally to support their hormone health and reproductive lifespan. Dr. Marina introduces the idea of “biological age” versus chronological age. While we cannot stop time, she explains that the health of our bodies is deeply influenced by lifestyle choices. The same habits that support longevity. The conversation dives into practical, foundational approaches that often get overlooked in conventional medicine. Rather than focusing first on expensive biohacking trends, Dr. Marina encourages women to start simple: eat whole foods, reduce ultra-processed foods and sugar, move the body regularly, and prioritize nutrient sufficiency. She shares how deficiencies in nutrients like vitamin D, B12, magnesium, and omega-3s are incredibly common in her patients and can significantly impact hormone health and fertility. The hosts also discuss the overwhelming amount of health information women encounter online today. Dr. Marina reminds listeners that the basics matter most. A Mediterranean-style diet, reducing inflammatory foods, regular exercise, and stress management are still some of the most evidence-based ways to improve fertility and overall wellness. Another major topic of the episode is low-dose naltrexone (LDN), a therapy gaining attention in restorative reproductive medicine.More recently, she has seen promising use in fertility support, particularly for women with inflammatory conditions such as endometriosis and PCOS. She discusses both the potential benefits and considerations of using LDN, including common side effects like vivid dreams and sleep changes. The discussion also highlights the growing concern surrounding endocrine-disrupting chemicals in modern life. From plastics and water contaminants to personal care products and cleaning supplies, Dr. Marina explains how environmental toxins may be impacting fertility, hormone balance, and even sperm counts. She shares practical ways women can reduce exposure without becoming fearful, including using water filters, cleaner products, and tools like the Environmental Working Group's Healthy Living App. The episode closes with a beautiful reflection on body literacy and the importance of women understanding their cycles and hormones. Dr. Marina encourages women not to take fertility for granted and to become more in tune with the natural rhythms of their bodies. Her mission is simple but powerful: to help women understand that they are not powerless when it comes to their health and fertility. This episode is packed with practical wisdom, encouragement, and empowering reminders that small lifestyle changes can truly transform hormone health, fertility, and long-term wellness. Interested in being a Podcast Sponsor with THE HORMONE GENIUS? Check out these links next to get more detailson our SPONSORSHIP VISION! PODCAST PARTNER: https://docs.google.com/forms/d/e/1FAIpQLSdffY6WpATSUZfVtaQDlgCH1TDvvR5o3u-1G_sxUzQ0iRgHqg/viewform MONTHLY SPONSOR: https://docs.google.com/forms/d/e/1FAIpQLSeBmq62f7FcAs6aGqD_2wrHyWlXRm66bhzvqF2M1Pal5nkGyA/viewform BRAND PARTNER: https://docs.google.com/forms/d/e/1FAIpQLSfBu46XqvMbmi8dqt8LBzUE0r22Gj39Ou9tbXSeN6d8-G5qaA/viewform We love partnering with brands that align with our mission of empowering women through hormone education and whole-body health. Visit WeHeartNutrition.com and use code GENIUS for 20% off your first order. The information shared on the Hormone Genius Podcast is intended for educational and informational purposes only and should not be considered medical advice. The views and opinions expressed by guests are their own and do not necessarily reflect those of the podcast hosts or sponsors.

Can we get too much B12?