FX Omics

How do our genetics influence our fertility? Rates of infertility are on the rise, with one in six couples experiencing infertility. In this episode naturopath Amie Skilton discusses the range of potential causes, what has the biggest impacts on fertility and reproduction, and how genetics might contribute to the growing issue of infertility.  Find today's show notes and transcript here: https://www.fxmedicine.com.au/omicspodcast/genetic-polymorphisms-and-fertility-amie-skilton *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

We know ovulation is important for reproduction, but did you know that it’s a critical indicator of general health? In this episode, Lara Briden delves into the physiological role of ovulation outside of reproduction and takes us through the many health benefits women gain from quality ovulatory cycling. Lara shares how oestrogen helps regulate metabolic flexibility, why the brain loves oestrogen, and the importance of progesterone for immunity, neurological health and inflammation. Lara also goes into why shutting down ovulation with hormonal birth control is detrimental to women's wellbeing as well as how to differentiate between PCOS and hypothalamic amenorrhoea.Find today's show notes and transcript here: https://www.fxmedicine.com.au/omicspodcast/ovulation-beyond-reproduction-lara-briden *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

How often are you thinking about a patient's choline status? In this episode, Dr Jonathan Bortz discusses his journey into developing pharmaceuticals and supplements, and how it brought him to look at choline in a different light. He talks about the story of choline as a “one carbon metabolism,” as well as the various uses of choline in the body, including its role in methylation, genetics, and non-alcoholic fatty liver disease (NAFLD).Find today's show notes and transcript here: https://www.fxmedicine.com.au/omicspodcast/more-methylation-crucial-role-choline-dr-jonathan-bortz *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

We can alter the human genome, but is that really a good idea? In this brave new world, biohacking, a new system called CRISPR and gene editing may possibly be rewriting our futures. In today's episode, we talk to Dr Nessa Carey about the complex world of genetics and epigenetics, including discussions on the true purpose of so-called “junk DNA”. We also discuss how viruses may alter our genetic code, as well as the future of genetic and epigenetic editing and the moral dilemma surrounding this technology. Find today's podcast transcript and show notes here: https://www.fxmedicine.com.au/omicspodcast/hacking-genetic-code-dr-nessa-carey *****DISCLAIMER: The information provided on FX Omics is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

What if we completely reimagined the way we deliver healthcare, what would it look like and how would you do it? In this inspiring look into the future of functional medicine, entrepreneur and health advocate James Maskell discusses his work in revolutionising the medical model from one on one sessions with a doctor to shared healthcare with groups of people and teams of doctors, coaches, and practitioners in order to prevent and predict disease before it happens. Find today's show notes and transcript here: https://www.fxmedicine.com.au/content/evolution-functional-medicine-james-maskell *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

Are we thinking about genetics all wrong? Today we are joined by genomic analyst Lynda Sedley to tackle the controversial subject of nutritional epigenetics, modern genomic technologies and why clinicians need to be optimistically open to evolve epigenomics into personalised medicine. Find todays show notes and transcript here: https://www.fxmedicine.com.au/content/epigenome-rethinking-genetics-lynda-sedley *****DISCLAIMER: The information provided on FX Omics is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

The rate of Alzheimer's disease is predicted to triple by the year 2056. The question in personalised medicine is, can genetic screening and targeting modifiable risk factors downgrade the disease onset in identified at-risk individuals? In this week’s episode, nutritional genomics consultant Dr Sasja Beetstra-Hill guides us through the emerging connection the ApoE4 gene is showing as a predictive screening option for Alzheimer's disease risk. Could this assessment lead to earlier intervention and help clinicians and patients get out in front of Alzheimer's disease before it's progressed beyond the reach of therapy? Find today's transcript and show notes here: https://www.fxmedicine.com.au/content/apoe-alzheimers-connection-dr-sasja-beetstra-hill *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

How do we take a big picture approach to our patient's personalised health journey? Today we are joined by Alessandra Edwards who is well versed in using a vast variety of technology and testing to yield ideal results from her clients no matter where they are on their journey to wellbeing. Find today's transcript and show notes here: https://www.fxmedicine.com.au/content/technology-and-testing-personalised-medicine-alessandra-edwards *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

What dietary, environmental and lifestyle factors pose a risk to our DNA? Today we are joined by Professor Michael Fenech, an internationally recognised researcher in nutritional genomics and genetic toxicology. Prof Fenech shares with us the mechanisms of DNA damage and the role that the assessment of micronuclei may play in evaluating a person's genetic status regarding exposure to environmental genotoxins and dietary deficiencies. Find today's transcript and show notes here: https://www.fxmedicine.com.au/content/mechanisms-dna-damage-prof-michael-fenech *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

In the words of Dr Yael Joffe, health practitioners of all disciplines need to engage in learning about genetics and genomics or risk being left behind. Tune in to today's episode as Mark and Yael discuss the differences between nutrigenetics and nutrigenomics, why nutrition is a more sustainable choice over drug therapies, the role of Nrf2 as a master regulator and why MTHFR was nutrigenomics 'darkest hour'. Find today's show notes and transcript here: https://www.fxmedicine.com.au/content/nutrigenomics-and-future-healthcare-dr-yael-joffe *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

Don’t underestimate the power of food in our past, present and future evolutionary biology. Today, Mark is talking with Dr Christine Houghton who has amassed over three decades of wisdom in clinical nutrition and has a passion for the interplay of nutrigenomics with the food and nutrients we consume. Christine takes us back to the basics with a review of the terminology that makes up the field of genetics in healthcare. She navigates us through the epigenetic and gene expression effects of the foods we eat, the microbiome and the influence our genes have on many pathways of the body including methylation, inflammation and detoxification. One message is resoundingly clear: when it comes to positively influencing our genes, there is no single supplementary intervention that can substitute for the complexities of the phytonutrients we obtain from having a diet rich in diverse foods. Find todays show notes and transcript here: https://www.fxmedicine.com.au/content/nutrigenomics-you-are-what-you-eat-dr-christine-houghton *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

Elizma Lambert is a complex-case detective who enjoys identifying patterns in her patients' signs and symptoms, genetics, environment and functional testing. In today's interview she shares with us how she selects the screening tools she uses to guide her clinical decisions. Elizma discusses, with some great clinical examples, why she chooses organic acid testing, genetic SNP testing, microbiological testing and heavy metal screening in her complex cases to help her uncover the blocks in a person's healing journey. Find today's show notes and transcript here: https://www.fxmedicine.com.au/content/biomarker-patterns-personalised-medicine-elizma-lambert *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

In Australia, if you've heard about MTHFR chances are you've come across the work of Carolyn Ledowsky. Carolyn is the founder of MTHFR Support Australia and has long been a trailblazer for personalised medicine using genetic testing. Today Carolyn shares how MTHFR SNPs first came on her radar and how it changed the way she practiced and opened up the world of interpreting genetic results to maximise clinical outcomes. Find today's show notes and transcript here: https://www.fxmedicine.com.au/content/methylation-epigenetics-and-beyond-carolyn-ledowsky *****DISCLAIMER: The information provided on FX Omics is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

Is the ketogenic diet suitable for everyone? Today we are joined by Dr Dominic D'Agostino who is an associate professor and research scientist with interests in neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology.Dr D'Agostino is a world leading expert in the scientific applications of keto nutrition, his laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, seizures, cancer and metabolic wellness. Dr D'Agostino's expertise in ketosis has led to him working with astronauts, athletes and the military. In today's episode Dr D'Agostino shares how the body uses ketones, the difference between pathological and therapeutic ketosis and the reasons why not everyone may be bio-compatible with a ketogenic diet. Find today's show notes and transcript here: https://www.fxmedicine.com.au/content/understanding-therapeutic-ketosis-dr-dominic-dagostino *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

Once described as “part Freud, part Sherlock Holmes”, Dr Jay Lombard is an internationally acclaimed neurologist, author, and keynote speaker. Dr Lombard’s discoveries are widely regarded as fundamentally shifting the paradigm of psychiatric medicine. In today’s episode, Dr Lombard untangles the genetics of mental illness and shares his wholistic approach to brain health and neuropsychiatric conditions. Find today's transcript and show notes here: https://www.fxmedicine.com.au/content/untangling-genetics-mental-health-dr-jay-lombard   *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

What is culinary genomics? Today we are joined by Amanda Archibald, founder of "The Genomic Kitchen." Amanda has a vision for bringing genomic science into the public health system and onto the plates of everyday consumers. Amanda takes us through the steps she's taken to get hospitals in California to pilot a program to bring a nutrigenomic approach to the foods they're serving. She also discusses how genomics helps us to see nutritional biochemistry in 3D and how it can help us to connect the dots and move away from the traditional, reductionist approach to food selection. Find today's transcript and show notes here: https://www.fxmedicine.com.au/content/culinary-genomics-matching-your-food-your-genes-amanda-archibald *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

Personalised medicine is in high demand and more and more people are turning to genetic testing to better understand the nuances of their individualised health care. As a foremost expert in genetics, particularly nutrigenomics, Dr Denise Furness is in high demand as an educator to both clinicians, researchers and consumers on this growing area of healthcare. Denise joins us today to give us a "Genetics 101," highlighting the many opportunities that genetic testing opens up in clinical practice for delivering personalised, empowered health choices to patients. Today's transcript and show notes can be found here: https://www.fxmedicine.com.au/content/clinical-opportunities-genetic-testing-dr-denise-furness *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

FX Omics