Podcasts about alzheimer's disease

En este episodio Laura Miranda Olivera conversa con Édgar Cortés sobre el trastorno neurocognitivo más común, su neurobiología, una investigación presentada en Texas, y recomendaciones de estilo de vida.

Sinopsis:Carolina Alonso siempre creyó tener una vida perfecta en el pueblo que la vio crecer. Huérfana de madre desde los doce años y abandonada por su padre, encontró en sus abuelos, Emma y Armando, el refugio para una infancia feliz. De novia con Diego, apasionada por su trabajo como maestra y rodeada de amigas de toda la vida, nunca imaginó que todo cambiaría el día en que a su abuela le diagnosticaron Alzheimer. Decidida a estar a su lado, emprenderá un camino de transformación, sin saber que su destino también está por reescribirse.Con las estrellas de testigo nos sumerge en historias de amor que renacen, recuerdos que sanan y reflexiones que perduran. A través de sus páginas, descubriremos cómo, incluso en los momentos más oscuros, la fuerza del amor y el poder de la memoria pueden iluminar nuestro camino, brindándonos esperanza, consuelo y la certeza de que algunas emociones trascienden el tiempo. Una invitación a redescubrir el valor de los sentimientos genuinos y la magia de las segundas oportunidades.Editorial BarenhausAutora Andrea LagoReseña por @celinacocimano

“To navigate proof, we must reach into a thicket of errors and biases. We must confront monsters and embrace uncertainty, balancing — and rebalancing —our beliefs. We must seek out every useful fragment of data, gather every relevant tool, searching wider and climbing further. Finding the good foundations among the bad. Dodging dogma and falsehoods. Questioning. Measuring. Triangulating. Convincing. Then perhaps, just perhaps, we'll reach the truth in time.”—Adam KucharskiMy conversation with Professor Kucharski on what constitutes certainty and proof in science (and other domains), with emphasis on many of the learnings from Covid. Given the politicization of science and A.I.'s deepfakes and power for blurring of truth, it's hard to think of a topic more important right now.Audio file (Ground Truths can also be downloaded on Apple Podcasts and Spotify)Eric Topol (00:06):Hello, it's Eric Topol from Ground Truths and I am really delighted to welcome Adam Kucharski, who is the author of a new book, Proof: The Art and Science of Certainty. He's a distinguished mathematician, by the way, the first mathematician we've had on Ground Truths and a person who I had the real privilege of getting to know a bit through the Covid pandemic. So welcome, Adam.Adam Kucharski (00:28):Thanks for having me.Eric Topol (00:30):Yeah, I mean, I think just to let everybody know, you're a Professor at London School of Hygiene and Tropical Medicine and also noteworthy you won the Adams Prize, which is one of the most impressive recognitions in the field of mathematics. This is the book, it's a winner, Proof and there's so much to talk about. So Adam, maybe what I'd start off is the quote in the book that captivates in the beginning, “life is full of situations that can reveal remarkably large gaps in our understanding of what is true and why it's true. This is a book about those gaps.” So what was the motivation when you undertook this very big endeavor?Adam Kucharski (01:17):I think a lot of it comes to the work I do at my day job where we have to deal with a lot of evidence under pressure, particularly if you work in outbreaks or emerging health concerns. And often it really pushes the limits, our methodology and how we converge on what's true subject to potential revision in the future. I think particularly having a background in math's, I think you kind of grow up with this idea that you can get to these concrete, almost immovable truths and then even just looking through the history, realizing that often isn't the case, that there's these kind of very human dynamics that play out around them. And it's something I think that everyone in science can reflect on that sometimes what convinces us doesn't convince other people, and particularly when you have that kind of urgency of time pressure, working out how to navigate that.Eric Topol (02:05):Yeah. Well, I mean I think these times of course have really gotten us to appreciate, particularly during Covid, the importance of understanding uncertainty. And I think one of the ways that we can dispel what people assume they know is the famous Monty Hall, which you get into a bit in the book. So I think everybody here is familiar with that show, Let's Make a Deal and maybe you can just take us through what happens with one of the doors are unveiled and how that changes the mathematics.Adam Kucharski (02:50):Yeah, sure. So I think it is a problem that's been around for a while and it's based on this game show. So you've got three doors that are closed. Behind two of the doors there is a goat and behind one of the doors is a luxury car. So obviously, you want to win the car. The host asks you to pick a door, so you point to one, maybe door number two, then the host who knows what's behind the doors opens another door to reveal a goat and then ask you, do you want to change your mind? Do you want to switch doors? And a lot of the, I think intuition people have, and certainly when I first came across this problem many years ago is well, you've got two doors left, right? You've picked one, there's another one, it's 50-50. And even some quite well-respected mathematicians.Adam Kucharski (03:27):People like Paul Erdős who was really published more papers than almost anyone else, that was their initial gut reaction. But if you work through all of the combinations, if you pick this door and then the host does this, and you switch or not switch and work through all of those options. You actually double your chances if you switch versus sticking with the door. So something that's counterintuitive, but I think one of the things that really struck me and even over the years trying to explain it is convincing myself of the answer, which was when I first came across it as a teenager, I did quite quickly is very different to convincing someone else. And even actually Paul Erdős, one of his colleagues showed him what I call proof by exhaustion. So go through every combination and that didn't really convince him. So then he started to simulate and said, well, let's do a computer simulation of the game a hundred thousand times. And again, switching was this optimal strategy, but Erdős wasn't really convinced because I accept that this is the case, but I'm not really satisfied with it. And I think that encapsulates for a lot of people, their experience of proof and evidence. It's a fact and you have to take it as given, but there's actually quite a big bridge often to really understanding why it's true and feeling convinced by it.Eric Topol (04:41):Yeah, I think it's a fabulous example because I think everyone would naturally assume it's 50-50 and it isn't. And I think that gets us to the topic at hand. What I love, there's many things I love about this book. One is that you don't just get into science and medicine, but you cut across all the domains, law, mathematics, AI. So it's a very comprehensive sweep of everything about proof and truth, and it couldn't come at a better time as we'll get into. Maybe just starting off with math, the term I love mathematical monsters. Can you tell us a little bit more about that?Adam Kucharski (05:25):Yeah, this was a fascinating situation that emerged in the late 19th century where a lot of math's, certainly in Europe had been derived from geometry because a lot of the ancient Greek influence on how we shaped things and then Newton and his work on rates of change and calculus, it was really the natural world that provided a lot of inspiration, these kind of tangible objects, tangible movements. And as mathematicians started to build out the theory around rates of change and how we tackle these kinds of situations, they sometimes took that intuition a bit too seriously. And there was some theorems that they said were intuitively obvious, some of these French mathematicians. And so, one for example is this idea of you how things change smoothly over time and how you do those calculations. But what happened was some mathematicians came along and showed that when you have things that can be infinitely small, that intuition didn't necessarily hold in the same way.Adam Kucharski (06:26):And they came up with these examples that broke a lot of these theorems and a lot of the establishments at the time called these things monsters. They called them these aberrations against common sense and this idea that if Newton had known about them, he never would've done all of his discovery because they're just nuisances and we just need to get rid of them. And there's this real tension at the core of mathematics in the late 1800s where some people just wanted to disregard this and say, look, it works for most of the time, that's good enough. And then others really weren't happy with this quite vague logic. They wanted to put it on much sturdier ground. And what was remarkable actually is if you trace this then into the 20th century, a lot of these monsters and these particularly in some cases functions which could almost move constantly, this constant motion rather than our intuitive concept of movement as something that's smooth, if you drop an apple, it accelerates at a very smooth rate, would become foundational in our understanding of things like probability, Einstein's work on atomic theory. A lot of these concepts where geometry breaks down would be really important in relativity. So actually, these things that we thought were monsters actually were all around us all the time, and science couldn't advance without them. So I think it's just this remarkable example of this tension within a field that supposedly concrete and the things that were going to be shunned actually turn out to be quite important.Eric Topol (07:53):It's great how you convey how nature isn't so neat and tidy and things like Brownian motion, understanding that, I mean, just so many things that I think fit into that general category. In the legal, we won't get into too much because that's not so much the audience of Ground Truths, but the classic things about innocent and until proven guilty and proof beyond reasonable doubt, I mean these are obviously really important parts of that overall sense of proof and truth. We're going to get into one thing I'm fascinated about related to that subsequently and then in science. So before we get into the different types of proof, obviously the pandemic is still fresh in our minds and we're an endemic with Covid now, and there are so many things we got wrong along the way of uncertainty and didn't convey that science isn't always evolving search for what is the truth. There's plenty no shortage of uncertainty at any moment. So can you recap some of the, you did so much work during the pandemic and obviously some of it's in the book. What were some of the major things that you took out of proof and truth from the pandemic?Adam Kucharski (09:14):I think it was almost this story of two hearts because on the one hand, science was the thing that got us where we are today. The reason that so much normality could resume and so much risk was reduced was development of vaccines and the understanding of treatments and the understanding of variants as they came to their characteristics. So it was kind of this amazing opportunity to see this happen faster than it ever happened in history. And I think ever in science, it certainly shifted a lot of my thinking about what's possible and even how we should think about these kinds of problems. But also on the other hand, I think where people might have been more familiar with seeing science progress a bit more slowly and reach consensus around some of these health issues, having that emerge very rapidly can present challenges even we found with some of the work we did on Alpha and then the Delta variants, and it was the early quantification of these.Adam Kucharski (10:08):So really the big question is, is this thing more transmissible? Because at the time countries were thinking about control measures, thinking about relaxing things, and you've got this just enormous social economic health decision-making based around essentially is it a lot more spreadable or is it not? And you only had these fragments of evidence. So I think for me, that was really an illustration of the sharp end. And I think what we ended up doing with some of those was rather than arguing over a precise number, something like Delta, instead we kind of looked at, well, what's the range that matters? So in the sense of arguing over whether it's 40% or 50% or 30% more transmissible is perhaps less important than being, it's substantially more transmissible and it's going to start going up. Is it going to go up extremely fast or just very fast?Adam Kucharski (10:59):That's still a very useful conclusion. I think what often created some of the more challenges, I think the things that on reflection people looking back pick up on are where there was probably overstated certainty. We saw that around some of the airborne spread, for example, stated as a fact by in some cases some organizations, I think in some situations as well, governments had a constraint and presented it as scientific. So the UK, for example, would say testing isn't useful. And what was happening at the time was there wasn't enough tests. So it was more a case of they can't test at that volume. But I think blowing between what the science was saying and what the decision-making, and I think also one thing we found in the UK was we made a lot of the epidemiological evidence available. I think that was really, I think something that was important.Adam Kucharski (11:51):I found it a lot easier to communicate if talking to the media to be able to say, look, this is the paper that's out, this is what it means, this is the evidence. I always found it quite uncomfortable having to communicate things where you knew there were reports behind the scenes, but you couldn't actually articulate. But I think what that did is it created this impression that particularly epidemiology was driving the decision-making a lot more than it perhaps was in reality because so much of that was being made public and a lot more of the evidence around education or economics was being done behind the scenes. I think that created this kind of asymmetry in public perception about how that was feeding in. And so, I think there was always that, and it happens, it is really hard as well as a scientist when you've got journalists asking you how to run the country to work out those steps of am I describing the evidence behind what we're seeing? Am I describing the evidence about different interventions or am I proposing to some extent my value system on what we do? And I think all of that in very intense times can be very easy to get blurred together in public communication. I think we saw a few examples of that where things were being the follow the science on policy type angle where actually once you get into what you're prioritizing within a society, quite rightly, you've got other things beyond just the epidemiology driving that.Eric Topol (13:09):Yeah, I mean that term that you just use follow the science is such an important term because it tells us about the dynamic aspect. It isn't just a snapshot, it's constantly being revised. But during the pandemic we had things like the six-foot rule that was never supported by data, but yet still today, if I walk around my hospital and there's still the footprints of the six-foot rule and not paying attention to the fact that this was airborne and took years before some of these things were accepted. The flatten the curve stuff with lockdowns, which I never was supportive of that, but perhaps at the worst point, the idea that hospitals would get overrun was an issue, but it got carried away with school shutdowns for prolonged periods and in some parts of the world, especially very stringent lockdowns. But anyway, we learned a lot.Eric Topol (14:10):But perhaps one of the greatest lessons is that people's expectations about science is that it's absolute and somehow you have this truth that's not there. I mean, it's getting revised. It's kind of on the job training, it's on this case on the pandemic revision. But very interesting. And that gets us to, I think the next topic, which I think is a fundamental part of the book distributed throughout the book, which is the different types of proof in biomedicine and of course across all these domains. And so, you take us through things like randomized trials, p-values, 95 percent confidence intervals, counterfactuals, causation and correlation, peer review, the works, which is great because a lot of people have misconceptions of these things. So for example, randomized trials, which is the temple of the randomized trials, they're not as great as a lot of people think, yes, they can help us establish cause and effect, but they're skewed because of the people who come into the trial. So they may not at all be a representative sample. What are your thoughts about over deference to randomized trials?Adam Kucharski (15:31):Yeah, I think that the story of how we rank evidence in medicines a fascinating one. I mean even just how long it took for people to think about these elements of randomization. Fundamentally, what we're trying to do when we have evidence here in medicine or science is prevent ourselves from confusing randomness for a signal. I mean, that's fundamentally, we don't want to mistake something, we think it's going on and it's not. And the challenge, particularly with any intervention is you only get to see one version of reality. You can't give someone a drug, follow them, rewind history, not give them the drug and then follow them again. So one of the things that essentially randomization allows us to do is, if you have two groups, one that's been randomized, one that hasn't on average, the difference in outcomes between those groups is going to be down to the treatment effect.Adam Kucharski (16:20):So it doesn't necessarily mean in reality that'd be the case, but on average that's the expectation that you'd have. And it's kind of interesting actually that the first modern randomized control trial (RCT) in medicine in 1947, this is for TB and streptomycin. The randomization element actually, it wasn't so much statistical as behavioral, that if you have people coming to hospital, you could to some extent just say, we'll just alternate. We're not going to randomize. We're just going to first patient we'll say is a control, second patient a treatment. But what they found in a lot of previous studies was doctors have bias. Maybe that patient looks a little bit ill or that one maybe is on borderline for eligibility. And often you got these quite striking imbalances when you allowed it for human judgment. So it was really about shielding against those behavioral elements. But I think there's a few situations, it's a really powerful tool for a lot of these questions, but as you mentioned, one is this issue of you have the population you study on and then perhaps in reality how that translates elsewhere.Adam Kucharski (17:17):And we see, I mean things like flu vaccines are a good example, which are very dependent on immunity and evolution and what goes on in different populations. Sometimes you've had a result on a vaccine in one place and then the effectiveness doesn't translate in the same way to somewhere else. I think the other really important thing to bear in mind is, as I said, it's the averaging that you're getting an average effect between two different groups. And I think we see certainly a lot of development around things like personalized medicine where actually you're much more interested in the outcome for the individual. And so, what a trial can give you evidence is on average across a group, this is the effect that I can expect this intervention to have. But we've now seen more of the emergence things like N=1 studies where you can actually over the same individual, particularly for chronic conditions, look at those kind of interventions.Adam Kucharski (18:05):And also there's just these extreme examples where you're ethically not going to run a trial, there's never been a trial of whether it's a good idea to have intensive care units in hospitals or there's a lot of these kind of historical treatments which are just so overwhelmingly effective that we're not going to run trial. So almost this hierarchy over time, you can see it getting shifted because actually you do have these situations where other forms of evidence can get you either closer to what you need or just more feasibly an answer where it's just not ethical or practical to do an RCT.Eric Topol (18:37):And that brings us to the natural experiments I just wrote about recently, the one with shingles, which there's two big natural experiments to suggest that shingles vaccine might reduce the risk of Alzheimer's, an added benefit beyond the shingles that was not anticipated. Your thoughts about natural experiments, because here you're getting a much different type of population assessment, again, not at the individual level, but not necessarily restricted by some potentially skewed enrollment criteria.Adam Kucharski (19:14):I think this is as emerged as a really valuable tool. It's kind of interesting, in the book you're talking to economists like Josh Angrist, that a lot of these ideas emerge in epidemiology, but I think were really then taken up by economists, particularly as they wanted to add more credibility to a lot of these policy questions. And ultimately, it comes down to this issue that for a lot of problems, we can't necessarily intervene and randomize, but there might be a situation that's done it to some extent for us, so the classic example is the Vietnam draft where it was kind of random birthdays with drawn out of lottery. And so, there's been a lot of studies subsequently about the effect of serving in the military on different subsequent lifetime outcomes because broadly those people have been randomized. It was for a different reason. But you've got that element of randomization driving that.Adam Kucharski (20:02):And so again, with some of the recent shingles data and other studies, you might have a situation for example, where there's been an intervention that's somewhat arbitrary in terms of time. It's a cutoff on a birth date, for example. And under certain assumptions you could think, well, actually there's no real reason for the person on this day and this day to be fundamentally different. I mean, perhaps there might be effects of cohorts if it's school years or this sort of thing. But generally, this isn't the same as having people who are very, very different ages and very different characteristics. It's just nature, or in this case, just a policy intervention for a different reason has given you that randomization, which allows you or pseudo randomization, which allows you to then look at something about the effect of an intervention that you wouldn't as reliably if you were just digging into the data of yes, no who's received a vaccine.Eric Topol (20:52):Yeah, no, I think it's really valuable. And now I think increasingly given priority, if you can find these natural experiments and they're not always so abundant to use to extrapolate from, but when they are, they're phenomenal. The causation correlation is so big. The issue there, I mean Judea Pearl's, the Book of Why, and you give so many great examples throughout the book in Proof. I wonder if you could comment that on that a bit more because this is where associations are confused somehow or other with a direct effect. And we unfortunately make these jumps all too frequently. Perhaps it's the most common problem that's occurring in the way we interpret medical research data.Adam Kucharski (21:52):Yeah, I think it's an issue that I think a lot of people get drilled into in their training just because a correlation between things doesn't mean that that thing causes this thing. But it really struck me as I talked to people, researching the book, in practice in research, there's actually a bit more to it in how it's played out. So first of all, if there's a correlation between things, it doesn't tell you much generally that's useful for intervention. If two things are correlated, it doesn't mean that changing that thing's going to have an effect on that thing. There might be something that's influencing both of them. If you have more ice cream sales, it will lead to more heat stroke cases. It doesn't mean that changing ice cream sales is going to have that effect, but it does allow you to make predictions potentially because if you can identify consistent patterns, you can say, okay, if this thing going up, I'm going to make a prediction that this thing's going up.Adam Kucharski (22:37):So one thing I found quite striking, actually talking to research in different fields is how many fields choose to focus on prediction because it kind of avoids having to deal with this cause and effect problem. And even in fields like psychology, it was kind of interesting that there's a lot of focus on predicting things like relationship outcomes, but actually for people, you don't want a prediction about your relationship. You want to know, well, how can I do something about it? You don't just want someone to sell you your relationship's going to go downhill. So there's almost part of the challenge is people just got stuck on prediction because it's an easier field of work, whereas actually some of those problems will involve intervention. I think the other thing that really stood out for me is in epidemiology and a lot of other fields, rightly, people are very cautious to not get that mixed up.Adam Kucharski (23:24):They don't want to mix up correlations or associations with causation, but you've kind of got this weird situation where a lot of papers go out of their way to not use causal language and say it's an association, it's just an association. It's just an association. You can't say anything about causality. And then the end of the paper, they'll say, well, we should think about introducing more of this thing or restricting this thing. So really the whole paper and its purpose is framed around a causal intervention, but it's extremely careful throughout the paper to not frame it as a causal claim. So I think we almost by skirting that too much, we actually avoid the problems that people sometimes care about. And I think a lot of the nice work that's been going on in causal inference is trying to get people to confront this more head on rather than say, okay, you can just stay in this prediction world and that's fine. And then just later maybe make a policy suggestion off the back of it.Eric Topol (24:20):Yeah, I think this is cause and effect is a very alluring concept to support proof as you so nicely go through in the book. But of course, one of the things that we use to help us is the biological mechanism. So here you have, let's say for example, you're trying to get a new drug approved by the Food and Drug Administration (FDA), and the request is, well, we want two trials, randomized trials, independent. We want to have p-values that are significant, and we want to know the biological mechanism ideally with the dose response of the drug. But there are many drugs as you review that have no biological mechanism established. And even when the tobacco problems were mounting, the actual mechanism of how tobacco use caused cancer wasn't known. So how important is the biological mechanism, especially now that we're well into the AI world where explainability is demanded. And so, we don't know the mechanism, but we also don't know the mechanism and lots of things in medicine too, like anesthetics and even things as simple as aspirin, how it works and many others. So how do we deal with this quest for the biological mechanism?Adam Kucharski (25:42):I think that's a really good point. It shows almost a lot of the transition I think we're going through currently. I think particularly for things like smoking cancer where it's very hard to run a trial. You can't make people randomly take up smoking. Having those additional pieces of evidence, whether it's an analogy with a similar carcinogen, whether it's a biological mechanism, can help almost give you more supports for that argument that there's a cause and effect going on. But I think what I found quite striking, and I realized actually that it's something that had kind of bothered me a bit and I'd be interested to hear whether it bothers you, but with the emergence of AI, it's almost a bit of the loss of scientific satisfaction. I think you grow up with learning about how the world works and why this is doing what it's doing.Adam Kucharski (26:26):And I talked for example of some of the people involved with AlphaFold and some of the subsequent work in installing those predictions about structures. And they'd almost made peace with it, which I found interesting because I think they started off being a bit uncomfortable with like, yeah, you've got these remarkable AI models making these predictions, but we don't understand still biologically what's happening here. But I think they're just settled in saying, well, biology is really complex on some of these problems, and if we can have a tool that can give us this extremely valuable information, maybe that's okay. And it was just interesting that they'd really kind of gone through that kind process, which I think a lot of people are still grappling with and that almost that discomfort of using AI and what's going to convince you that that's a useful reliable prediction whether it's something like predicting protein folding or getting in a self-driving car. What's the evidence you need to convince you that's reliable?Eric Topol (27:26):Yeah, no, I'm so glad you brought that up because when Demis Hassabis and John Jumper won the Nobel Prize, the point I made was maybe there should be an asterisk with AI because they don't know how it works. I mean, they had all the rich data from the protein data bank, and they got the transformer model to do it for 200 million protein structure prediction, but they still to this day don't fully understand how the model really was working. So it reinforces what you're just saying. And of course, it cuts across so many types of AI. It's just that we tend to hold different standards in medicine not realizing that there's lots of lack of explainability for routine medical treatments today. Now one of the things that I found fascinating in your book, because there's different levels of proof, different types of proof, but solid logical systems.Eric Topol (28:26):And on page 60 of the book, especially pertinent to the US right now, there is a bit about Kurt Gödel and what he did there was he basically, there was a question about dictatorship in the US could it ever occur? And Gödel says, “oh, yes, I can prove it.” And he's using the constitution itself to prove it, which I found fascinating because of course we're seeing that emerge right now. Can you give us a little bit more about this, because this is fascinating about the Fifth Amendment, and I mean I never thought that the Constitution would allow for a dictatorship to emerge.Adam Kucharski (29:23):And this was a fascinating story, Kurt Gödel who is one of the greatest logical minds of the 20th century and did a lot of work, particularly in the early 20th century around system of rules, particularly things like mathematics and whether they can ever be really fully satisfying. So particularly in mathematics, he showed that there were this problem that is very hard to have a set of rules for something like arithmetic that was both complete and covered every situation, but also had no contradictions. And I think a lot of countries, if you go back, things like Napoleonic code and these attempts to almost write down every possible legal situation that could be imaginable, always just ascended into either they needed amendments or they had contradictions. I think Gödel's work really summed it up, and there's a story, this is in the late forties when he had his citizenship interview and Einstein and Oskar Morgenstern went along as witnesses for him.Adam Kucharski (30:17):And it's always told as kind of a lighthearted story as this logical mind, this academic just saying something silly in front of the judge. And actually, to my own admission, I've in the past given talks and mentioned it in this slightly kind of lighthearted way, but for the book I got talking to a few people who'd taken it more seriously. I realized actually he's this extremely logically focused mind at the time, and maybe there should have been something more to it. And people who have kind of dug more into possibilities was saying, well, what could he have spotted that bothered him? And a lot of his work that he did about consistency in mass was around particularly self-referential statements. So if I say this sentence is false, it's self-referential and if it is false, then it's true, but if it's true, then it's false and you get this kind of weird self-referential contradictions.Adam Kucharski (31:13):And so, one of the theories about Gödel was that in the Constitution, it wasn't that there was a kind of rule for someone can become a dictator, but rather people can use the mechanisms within the Constitution to make it easier to make further amendments. And he kind of downward cycle of amendment that he had seen happening in Europe and the run up to the war, and again, because this is never fully documented exactly what he thought, but it's one of the theories that it wouldn't just be outright that it would just be this cycle process of weakening and weakening and weakening and making it easier to add. And actually, when I wrote that, it was all the earlier bits of the book that I drafted, I did sort of debate whether including it I thought, is this actually just a bit in the weeds of American history? And here we are. Yeah, it's remarkable.Eric Topol (32:00):Yeah, yeah. No, I mean I found, it struck me when I was reading this because here back in 1947, there was somebody predicting that this could happen based on some, if you want to call it loopholes if you will, or the ability to change things, even though you would've thought otherwise that there wasn't any possible capability for that to happen. Now, one of the things I thought was a bit contradictory is two parts here. One is from Angus Deaton, he wrote, “Gold standard thinking is magical thinking.” And then the other is what you basically are concluding in many respects. “To navigate proof, we must reach into a thicket of errors and biases. We must confront monsters and embrace uncertainty, balancing — and rebalancing —our beliefs. We must seek out every useful fragment of data, gather every relevant tool, searching wider and climbing further. Finding the good foundations among the bad. Dodging dogma and falsehoods. Questioning. Measuring. Triangulating. Convincing. Then perhaps, just perhaps, we'll reach the truth in time.” So here you have on the one hand your search for the truth, proof, which I think that little paragraph says it all. In many respects, it sums up somewhat to the work that you review here and on the other you have this Nobel laureate saying, you don't have to go to extremes here. The enemy of good is perfect, perhaps. I mean, how do you reconcile this sense that you shouldn't go so far? Don't search for absolute perfection of proof.Adam Kucharski (33:58):Yeah, I think that encapsulates a lot of what the book is about, is that search for certainty and how far do you have to go. I think one of the things, there's a lot of interesting discussion, some fascinating papers around at what point do you use these studies? What are their flaws? But I think one of the things that does stand out is across fields, across science, medicine, even if you going to cover law, AI, having these kind of cookie cutter, this is the definitive way of doing it. And if you just follow this simple rule, if you do your p-value, you'll get there and you'll be fine. And I think that's where a lot of the danger is. And I think that's what we've seen over time. Certain science people chasing certain targets and all the behaviors that come around that or in certain situations disregarding valuable evidence because you've got this kind of gold standard and nothing else will do.Adam Kucharski (34:56):And I think particularly in a crisis, it's very dangerous to have that because you might have a low level of evidence that demands a certain action and you almost bias yourself towards inaction if you have these kind of very simple thresholds. So I think for me, across all of these stories and across the whole book, I mean William Gosset who did a lot of pioneering work on statistical experiments at Guinness in the early 20th century, he had this nice question he sort of framed is, how much do we lose? And if we're thinking about the problems, there's always more studies we can do, there's always more confidence we can have, but whether it's a patient we want to treat or crisis we need to deal with, we need to work out actually getting that level of proof that's really appropriate for where we are currently.Eric Topol (35:49):I think exceptionally important that there's this kind of spectrum or continuum in following science and search for truth and that distinction, I think really nails it. Now, one of the things that's unique in the book is you don't just go through all the different types of how you would get to proof, but you also talk about how the evidence is acted on. And for example, you quote, “they spent a lot of time misinforming themselves.” This is the whole idea of taking data and torturing it or using it, dredging it however way you want to support either conspiracy theories or alternative facts. Basically, manipulating sometimes even emasculating what evidence and data we have. And one of the sentences, or I guess this is from Sir Francis Bacon, “truth is a daughter of time”, but the added part is not authority. So here we have our president here that repeats things that are wrong, fabricated or wrong, and he keeps repeating to the point that people believe it's true. But on the other hand, you could say truth is a daughter of time because you like to not accept any truth immediately. You like to see it get replicated and further supported, backed up. So in that one sentence, truth is a daughter of time not authority, there's the whole ball of wax here. Can you take us through that? Because I just think that people don't understand that truth being tested over time, but also manipulated by its repetition. This is a part of the big problem that we live in right now.Adam Kucharski (37:51):And I think it's something that writing the book and actually just reflecting on it subsequently has made me think about a lot in just how people approach these kinds of problems. I think that there's an idea that conspiracy theorists are just lazy and have maybe just fallen for a random thing, but talking to people, you really think about these things a lot more in the field. And actually, the more I've ended up engaging with people who believe things that are just outright unevidenced around vaccines, around health issues, they often have this mountain of papers and data to hand and a lot of it, often they will be peer reviewed papers. It won't necessarily be supporting the point that they think it's supports.Adam Kucharski (38:35):But it's not something that you can just say everything you're saying is false, that there's actually often a lot of things that have been put together and it's just that leap to that conclusion. I think you also see a lot of scientific language borrowed. So I gave a talker early this year and it got posted on YouTube. It had conspiracy theories it, and there was a lot of conspiracy theory supporters who piled in the comments and one of the points they made is skepticism is good. It's the kind of law society, take no one's word for it, you need this. We are the ones that are kind of doing science and people who just assume that science is settled are in the wrong. And again, you also mentioned that repetition. There's this phenomenon, it's the illusory truth problem that if you repeatedly tell someone someone's something's false, it'll increase their belief in it even if it's something quite outrageous.Adam Kucharski (39:27):And that mimics that scientific repetition because people kind of say, okay, well if I've heard it again and again, it's almost like if you tweak these as mini experiments, I'm just accumulating evidence that this thing is true. So it made me think a lot about how you've got essentially a lot of mimicry of the scientific method, amount of data and how you present it and this kind of skepticism being good, but I think a lot of it comes down to as well as just looking at theological flaws, but also ability to be wrong in not actually seeking out things that confirm. I think all of us, it's something that I've certainly tried to do a lot working on emergencies, and one of the scientific advisory groups that I worked on almost it became a catchphrase whenever someone presented something, they finished by saying, tell me why I'm wrong.Adam Kucharski (40:14):And if you've got a variant that's more transmissible, I don't want to be right about that really. And it is something that is quite hard to do and I found it is particularly for something that's quite high pressure, trying to get a policymaker or someone to write even just non-publicly by themselves, write down what you think's going to happen or write down what would convince you that you are wrong about something. I think particularly on contentious issues where someone's got perhaps a lot of public persona wrapped up in something that's really hard to do, but I think it's those kind of elements that distinguish between getting sucked into a conspiracy theory and really seeking out evidence that supports it and trying to just get your theory stronger and stronger and actually seeking out things that might overturn your belief about the world. And it's often those things that we don't want overturned. I think those are the views that we all have politically or in other ways, and that's often where the problems lie.Eric Topol (41:11):Yeah, I think this is perhaps one of, if not the most essential part here is that to try to deal with the different views. We have biases as you emphasized throughout, but if you can use these different types of proof to have a sound discussion, conversation, refutation whereby you don't summarily dismiss another view which may be skewed and maybe spurious or just absolutely wrong, maybe fabricated whatever, but did you can engage and say, here's why these are my proof points, or this is why there's some extent of certainty you can have regarding this view of the data. I think this is so fundamental because unfortunately as we saw during the pandemic, the strident minority, which were the anti-science, anti-vaxxers, they were summarily dismissed as being kooks and adopting conspiracy theories without the right engagement and the right debates. And I think this might've helped along the way, no less the fact that a lot of scientists didn't really want to engage in the first place and adopt this methodical proof that you've advocated in the book so many different ways to support a hypothesis or an assertion. Now, we've covered a lot here, Adam. Have I missed some central parts of the book and the effort because it's really quite extraordinary. I know it's your third book, but it's certainly a standout and it certainly it's a standout not just for your books, but books on this topic.Adam Kucharski (43:13):Thanks. And it's much appreciated. It was not an easy book to write. I think at times, I kind of wondered if I should have taken on the topic and I think a core thing, your last point speaks to that. I think a core thing is that gap often between what convinces us and what convinces someone else. I think it's often very tempting as a scientist to say the evidence is clear or the science has proved this. But even on something like the vaccines, you do get the loud minority who perhaps think they're putting microchips in people and outlandish views, but you actually get a lot more people who might just have some skepticism of pharmaceutical companies or they might have, my wife was pregnant actually at the time during Covid and we waited up because there wasn't much data on pregnancy and the vaccine. And I think it's just finding what is convincing. Is it having more studies from other countries? Is it understanding more about the biology? Is it understanding how you evaluate some of those safety signals? And I think that's just really important to not just think what convinces us and it's going to be obvious to other people, but actually think where are they coming from? Because ultimately having proof isn't that good unless it leads to the action that can make lives better.Eric Topol (44:24):Yeah. Well, look, you've inculcated my mind with this book, Adam, called Proof. Anytime I think of the word proof, I'm going to be thinking about you. So thank you. Thanks for taking the time to have a conversation about your book, your work, and I know we're going to count on you for the astute mathematics and analysis of outbreaks in the future, which we will see unfortunately. We are seeing now, in fact already in this country with measles and whatnot. So thank you and we'll continue to follow your great work.**************************************Thanks for listening, watching or reading this Ground Truths podcast/post.If you found this interesting please share it!That makes the work involved in putting these together especially worthwhile.I'm also appreciative for your subscribing to Ground Truths. All content —its newsletters, analyses, and podcasts—is free, open-access. I'm fortunate to get help from my producer Jessica Nguyen and Sinjun Balabanoff for audio/video tech support to pull these podcasts together for Scripps Research.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years.A bit of an update on SUPER AGERSMy book has been selected as a Next Big Idea Club winner for Season 26 by Adam Grant, Malcolm Gladwell, Susan Cain, and Daniel Pink. This club has spotlighted the most groundbreaking nonfiction books for over a decade. As a winning title, my book will be shipped to thousands of thoughtful readers like you, featured alongside a reading guide, a "Book Bite," Next Big Idea Podcast episode as well as a live virtual Q&A with me in the club's vibrant online community. If you're interested in joining the club, here's a promo code SEASON26 for 20% off at the website. SUPER AGERS reached #3 for all books on Amazon this week. This was in part related to the segment on the book on the TODAY SHOW which you can see here. Also at Amazon there is a remarkable sale on the hardcover book for $10.l0 at the moment for up to 4 copies. Not sure how long it will last or what prompted it.The journalist Paul von Zielbauer has a Substack “Aging With Strength” and did an extensive interview with me on the biology of aging and how we can prevent the major age-related diseases. Here's the link. Get full access to Ground Truths at erictopol.substack.com/subscribe

Too many people in the UK are stuck anxiously waiting up to a year for a dementia diagnosis — and even longer in more deprived areas. In this episode, we explore why early and accurate diagnosis matters, and what must change to fix the system. Host Sarah Dawood is joined by Samantha Benham-Hermetz, Executive Director at Alzheimer's Research UK; Chris Bane, Alzheimer's Research UK supporter; and Professor Vanessa Raymont, Consultant Psychiatrist and Associate Professor at the University of Oxford. Our panel discusses the urgent need for early and accurate dementia diagnosis, the impact of delayed diagnosis and the potential for new technologies, such as blood tests, to revolutionise the diagnosis pathway. They also explore the challenges facing the UK's memory services, new treatments becoming available and how the government's 10-Year Health Plan could reshape the future of dementia diagnosis so nobody faces dementia unseen. This New Statesman podcast episode is sponsored by Alzheimer's Research UK. Hosted on Acast. See acast.com/privacy for more information.

“Truth, Lies & Alzheimer's – Its Secret Faces” continues Skinner's quest of working with dementia-related illnesses and teaching families and caregivers how to better understand the daunting challenges that accompany these brain diseases. As someone who has had eight family members diagnosed with dementia, and a successful 30 yr career, Lisa has found her calling in helping others through the struggles so they can have a better-quality relationship with their loved ones - through education and by learning new strategies and techniques that offer effective solutions and tools to help them effectively manage the symptoms of brain disease. Through a rich trove of stories culled from her years in the eldercare industry, author Lisa Skinner offers insights into the difficult questions families face, including: - How do I respond to a loved one's false belief? - Am I abandoning my parent if I place them in the care of professionals? - How do we make the best of our time left together?

EP. 219: This one shook me. A brand new 2024 study in Advanced Science shows that botulinum toxin, the active ingredient in Botox, Dysport, and Xeomin, can travel to the brain, trigger inflammation, damage synapses, and create changes that closely resemble early Alzheimer's. In this episode, I break down what the researchers found, how it connects to microglial activation, chronic pain, memory, and hormone shifts. Topics Discussed: → Can Botox travel to your brain? → Does Botox increase your risk of Alzheimer's? → What does Botox do to brain cells? → Is microglial activation linked to Botox use? → Are neuromodulators like Dysport and Xeomin safe long-term? Sponsored By: → Sundays | As a Listener of The Dr Tyna Show, you can Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. → Puori | Go to Puori.com/drtyna and use code DRTYNA to get 20% off → LMNT | Get your free Sample Pack with any LMNT purchase at drinkLMNT.com/drtyna On This Episode We Cover:  → 00:00:00 - Introduction  → 00:05:23 - The brain & your immune system  → 00:07:24 - The microglial system → 00:09:29 - Study breakdown and findings  → 00:14:25 - Different forms of botox & side effects   Show Links: → Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflammatory Responses Further Listening:  → EP. 185 | 10 Health Trends We Are Ditching in 2025 | Solo Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

In this solo show I break down what Alzheimer's disease is, why so many studies show that tobacco smokers have higher risk for Alzheimer's, how the vitamin K shot given to infants differs from vitamin K supplements, and the specific and multiple mechanisms of how vitamin K2 works to prevent the development of Alzheimer's disease. I talk about the relationship between cadmium, lead, and Alzheimer's disease. I spend quite a bit of time talking about the difference between nicotine supplements and smoking tobacco, and why smoking may not be as bad as everyone says if other things are done to mitigate the harmful products of combustion. I name a unique terpene found in high amounts in tobacco that acts as a precursor to Coenzyme Q10 and vitamin K2 and it also has anti-inflammatory, neuroprotective, anti-tumor and antimicrobial properties. This episode is very detailed and technical. Get supercharged. Study referenced: https://www.mdpi.com/2072-6643/13/7/2206 My website: www.matt-blackburn.com Mitolife products: www.mitolife.co Music by Nicholas Jimenez: https://spoti.fi/4cte2nD

Anne Grey, President & CEO of Make-A-Wish Orange County & the Inland Empire, shares the organization's mission to bring hope to children with critical illnesses. She discusses the types of wishes granted, the qualification process, and the importance of community and volunteer involvement. Anne also reflects on her first year leading the chapter and the lasting impact of each wish. Anne Grey is a seasoned nonprofit leader with over 25 years of experience driving growth and impact at organizations such as Vivalon, the Alzheimer's Association, and the Pancreatic Cancer Action Network. Recognized as one of OC Register's Most Influential People in 2020, Anne is known for her strategic leadership and community-driven focus. She currently resides in both Irvine and Rancho Mirage, bringing a unique regional perspective to her work with Make-A-Wish. Anne holds a BA in International Relations from the University of San Diego and an MBA from Pepperdine University, and she actively volunteers with several local organizations.In this episode:Introducing this year's benefit charity: Make-A-Wish Orange County & the Inland EmpireAnne Grey shares the mission and impact of Make-A-WishTypes of wishes granted and how families are involved in the processAnne reflects on her first year as President & CEO and the emotional impact of wish experiencesUnderstanding the wish qualification process, including the urgency of rush wishesFundraising strategies and Make-A-Wish's financial goals for 2025The powerful impact of wishes on children, families, and communitiesThe vital role of volunteers in delivering hope and creating meaningful experiencesThe Norris Group originates and services loans in California and Florida under California DRE License 01219911, Florida Mortgage Lender License 1577, and NMLS License 1623669.  For more information on hard money lending, go www.thenorrisgroup.com and click the Hard Money tab.Video LinkRadio Show

Are you confident when amyloid is positron emission tomography (PET) is  appropriate, and how to avoid addendums to imaging reports?  Credit available for this activity expires: 6/23/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002659?ecd=bdc_podcast_libsyn_mscpedu

Attention: The first clinical trial testing creatine for Alzheimer's just dropped, and the results are absolutely mind-blowing. In this episode, I've sat down with Max Lugavere at The White House to discuss the new research on creatine. This pilot study gave 20 Alzheimer's patients 20 grams of creatine daily for 8 weeks. The results? Statistically significant improvements across nearly every cognitive measurement.  Join the Ultimate Human VIP community and gain exclusive access to Gary Brecka's proven wellness protocols today!: https://bit.ly/4ai0Xwg Get Max Lugavere book, “Genius Foods”: https://theultimatehuman.com/book-recs Want to dive deeper into brain health? Watch Max's documentary "Little Empty Boxes" here: https://bit.ly/47Qf8Y9 Listen to Max Lugavere's "The Genius Life" podcast weekly on all your favorite platforms: https://bit.ly/47MyoWK Connect with Max Lugavere: Website: https://bit.ly/3XLOGdN YouTube: https://bit.ly/4eJc6r7 Instagram: https://bit.ly/3BsEf7y Facebook: https://bit.ly/3Y4QkZr TikTok: https://bit.ly/3Y8ov2w X.com: https://bit.ly/3ZMQgPk LinkedIn: https://bit.ly/4eGVrEw Thank you to our partners: H2TABS - USE CODE “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg BODYHEALTH - USE CODE “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV BAJA GOLD - USE CODE "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa EIGHT SLEEP - SAVE $350 ON THE POD 4 ULTRA WITH CODE “GARY”: https://bit.ly/3WkLd6E COLD LIFE - THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp WHOOP - GET 1 FREE MONTH WHEN YOU JOIN!: https://bit.ly/3VQ0nzW MASA CHIPS - GET 20% OFF YOUR FIRST ORDER: https://bit.ly/40LVY4y VANDY - USE CODE “ULTIMATE20” FOR 20% OFF: https://bit.ly/49Qr7WE AION - USE CODE “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD HAPBEE - FEEL BETTER & PERFORM AT YOUR BEST: https://bit.ly/4a6glfo CARAWAY - USE CODE “ULTIMATE” FOR 10% OFF: https://bit.ly/3Q1VmkC HEALF - GET 10% OFF YOUR ORDER: https://bit.ly/41HJg6S BIOPTIMIZERS - USE CODE “ULTIMATE” FOR 10% OFF: https://bit.ly/4inFfd7 RHO NUTRITION - USE CODE “ULTIMATE15” FOR 15% OFF: https://bit.ly/44fFza0 GENETIC TEST: ⁠https://bit.ly/3Yg1Uk9 Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka: Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X.com: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps: 00:00 Intro 01:30 Getting Back to the Basics 02:17 Clinical Trial on Creatine  05:57 Impact of Creatine on Health 11:26 Spreading Awareness on Positive Healthcare Choices The Ultimate Human with Gary Brecka Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The Content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Learn more about your ad choices. Visit megaphone.fm/adchoices

For a more than a century, the Food and Drug Administration has worked to protect public health. In his research, Harvard University physician-researcher Jerry Avorn has examined how the FDA's once-rigorous gold standard approval process has been affected by a powerful shortcut known as the Accelerated Approval Program—originally designed for desperate AIDS and cancer patients. He says that change in the 1990s has allowed more than half of all new drugs onto the market before drug companies have proven they actually help people.In his new book Rethinking Medications: Truth, Power and the Drugs We Take, Avorn cites numerous examples: from a cold medicine that doesn't de-congest to billion-dollar cancer treatments that only shrink lab results to the controversial Alzheimer's drug Aduhelm—approved despite no clear cognitive benefits. In this episode, Avorn explores whether some prescriptions in your medicine cabinet are safe, effective and worth the money.

Matias and Greg interview Ying-Hui Fu, PhD, is a Professor of Neurology at UCSF and a world leader in the genetics of sleep. Her lab has discovered the first-known genes behind “natural short sleepers”. Her work bridges human genetics and neuroscience to uncover how to modulate sleep for brain health, aging, and neurodegenerative diseases.In this episode, we discuss:How some people thrive on 4–6 hours of sleep with rare genetic mutationsWhy sleep efficiency is more important than total hours sleptWhat short sleeper genes reveal about preventing Alzheimer's and autismWhy current sleep research tools miss deeper brain activity patternsWhat's next in sleep science with potential therapiesCredits:Created by Greg Kubin and Matias SerebrinskyHost: Matias Serebrinsky & Greg KubinProduced by Caitlin Ner & Nico V. Rey Find us at businesstrip.fm and psymed.venturesFollow us on Instagram and Twitter!Theme music by Dorian LoveAdditional Music: Distant Daze by Zack Frank

When a creative project lasts for many years, how do you create a cohesive story? How do you gather and organize that much research? At what point do you begin writing? How do you handle the changing of an editor? What happens when you don't know the ending? And what if you hoped for a different ending? We cover all these questions with Jennie Erin Smith, author of Valley of Forgetting, a book ten years in the making, about a vast Columbian family and the Alzheimer's researchers who studied them.Jennie Erin Smith is the author of Valley of Forgetting: Alzheimer's Families and the Search for a Cure. She is a regular contributor to The New York Times and has written for The Wall Street Journal, The Times Literary Supplement, The New Yorker, and others. She is a recipient of the Rona Jaffe Foundation Writers' Award; the Waldo Proffitt Award for Excellence in Environmental Journalism in Florida; and two first-place awards from the Society for Features Journalism. She lives in Florida and Colombia. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit emergingform.substack.com/subscribe

In a galaxy far far away ... there was a super spy named Cassian Andor and we love him! Join Kaiti, Phil, Robbie and Kris on this episode where the four talk all things secretive from the lastest season of Andor on Disney+. Hear opinions and details about the well written show by acclaimed screenwriter Tony Gilroy, known for Michael Clayton, The Bourne Series, Rogue One and many more. Rebellions are built on hope! And we hope you enjoy this episode of Muggle with a Mic!For more information on the Alzheimer's Association:alz.orgSupport our Walk Team here:https://act.alz.org/site/TR?team_id=945420&pg=team&fr_id=18816For more information on Final Boss Con:finalbosscon.comHelp support us by listening to episodes, liking posts, sharing our episodes with friends and family and subscribing on all the social media platforms including YouTube! All of these forms of support are free and easy to do but very much appreciated!Find more Muggle with a Mic content and YouTube videos here: linktr.ee/mugglewithamicMusic from this episode: "Take a Chance", Kevin MacLeod (incompetech.com) Licensed under Creative Commons

Erawadi Singh grew up sleeping on a sofa in the living room of her family's one-bedroom apartment in one of New Jersey's most difficult neighborhoods. Determined to give back, she would complete her schoolwork on the floor of her parents' bedroom, earning academic scholarships for higher educational pursuits while working to contribute to school tuition and helping care for her grandmother as she suffered from Alzheimer's dementia. Era earned a fine arts degree from Emerson College in Boston, where she graduated with honors, and then pursued her lifelong interest in medicine. She studied at Touro College (graduated with honors) and then took up residency at the University of Virginia, where she was chief resident and a finalist for the Medical Society of Virginia's doctor of the year in her final year. From there Era went to Yale University, where as a Geriatric Psychiatry fellow she was elected to represent members in training for the American Association of Geriatric Psychiatrists. Unfortunately, her efforts were sidelined by sustaining a thoracic level incomplete spinal cord injury on her graduation day! I had the great pleasure of meeting Era, and her AMAZING parents, at Kessler Institute for Rehabilitation last year. I'm thrilled that she has joined me, to tell us the rest of her story. So without further ado, I am proud to present, A Whole New Era…

Send us a textYour loved one's behavior isn't the source of your stress—your reaction to it is." This powerful insight forms the foundation of Rick Henkin's transformative approach to dementia caregiving, which he shares in this deeply moving episode.When Rick's wife Sonia was diagnosed with Alzheimer's at 65, their world shifted dramatically. From her developing Capgras syndrome (believing Rick was an imposter) to the heartbreak of seeing her relationship with their granddaughters deteriorate, Rick faced the crushing weight that so many caregivers experience. The turning point came not from changing his circumstances, but from changing his mindset.Rick takes us through his journey of discovery—how he went from anger and frustration to finding what he calls his "heaven on earth" state of peace and acceptance. He shares candid stories that will resonate with anyone who's cared for someone with dementia, from Sonia putting toothpaste in her hair to "borrowing" pancakes from strangers in restaurants. Rather than sources of stress, these moments became cherished memories through Rick's transformed perspective.Most powerfully, Rick reveals how his relationship with Sonia evolved to where spending time with her became his source of respite rather than stress. "Caregivers have the ability to make the rest of their loved one's life miserable or joyful," he notes—a profound responsibility and opportunity.Whether you're caring for someone with dementia or facing any caregiving challenges, Rick's practical wisdom offers a path forward. By focusing on what you can control—your own thoughts and reactions—rather than what you can't, you'll discover how to lift the burden of caregiving stress while providing better care for both your loved one and yourself.

We're getting bad news from what seems like every direction these days. Governments and media are all talking about wars and destruction. But this is not new.  We've been through these kinds of events before, too many times, and we're still here and moving forward. We can't let panic, wars and market crashes control our choices.  These thnigs happen without our input. We can control our clarity, courage and conviction to stay on course. If you've been considering planning for future extended care needs, or if you've been working on your plan, don't stop now.  Too many find a reason to pause and then forget their reasons for planning in the first place.  Then, 10 or 20 years go by, and something happens to them or someone close to them, and they restart their search. At that point, plans are much more expensive or not available due to age or health concerns. Let's work together to design your plan today and protect those you love most tomorrow. Schedule

Today, our podcast is all about the connection between stress and Alzheimer's disease, how stress affects brain health, what the science says, and most importantly, what we can do about it. Alzheimer's is tough, whether you're dealing with it yourself, caring for a loved one, or just trying to keep your brain sharp. And stress? We all have it, but too much of it can take a real toll on memory and overall health. That's why we're here—to break things down, talk to an expert, hear real stories, and share practical tips to help you manage stress and protect your mind.

Existen muchas deficiencias nutricionales que pueden causar inestabilidad en el cerebro, sobre todo en los niños. Hay muchos estudios que indican que el DMG y el Inositol pueden ayudar a niños con autismo y dificultades para aprender. La combinación de estos dos nutrientes con Cerebrin puede ayudar aún más, no solo a niños, sino también a adultos con problemas de enfoque y concentración, Alzheimer, depresión y tensión emocional. Puede obtener este Programa en LA Farmacia Natural en Los Angeles, Van Nuys, Huntington Park, El Monte, Arleta, Pico Rivera, Long Beach y en Burbank o llamando a la Línea de la Salud, al 1-800-227-8428 si desean que se lo enviemos a su casa.

June is Alzheimer's and Brain Awareness Month. We talk with Dr. Michele Longo from Tulane about what we know about Alzheimer's, what some of the symptoms and warning signs are, and how you can help take care of your brain in general as you age.

* Is there a conflict of interest in having the state education department run the GATOR program for private schools? * June is Alzheimer's and Brain Awareness Month.

* Is there a conflict of interest with the GATOR scholarship program? * How pharmacy benefit managers work...and what it means for patients * Churchill Downs tried to bluff lawmakers with the Fair Grounds future * City Park has a plan for the future. Here are the details * Buy Now, Pay Later plans will soon affect your credit score * Breaking down the Pelicans picks and moves in the first round * What we know about Alzheimer's and what to watch for

All Home Care Matters and our host, Lance A. Slatton were honored to welcome Michael Herrington & Kevin Hansen as guests to the show.   About Michael Herrington:   Michael Herrington is a passionate advocate for senior well-being and caregiver support. As President and Co-Founder of Ways 2 Wellness, he leads initiatives that combat loneliness and cognitive decline through engaging activity books and resources that keep seniors mentally sharp and emotionally connected.   With a strong background in publishing and marketing, Michael previously led large-scale sales and distribution efforts for major brands like Time Inc. and Comag Marketing Group. Now, he channels that expertise into Ways 2 Wellness, helping organizations create impactful, customized materials that enhance cognitive well-being and strengthen community connections.   About Ways 2 Wellness:   Ways 2 Wellness creates engaging, custom-branded activity books designed to reduce loneliness and enhance cognitive health in seniors. By combining mental stimulation with meaningful branding, these resources not only promote well-being but also support organizations in strengthening their presence and outreach.   About Kevin Hansen:   Kevin has helped hundreds of businesses with their branding/logo development, website presence, and digital marketing. For the last 8 years, he's worked with home care agencies throughout the country in satisfaction management and, more recently, in business development. He's the author or Branded by Design: Home Care / Home Health Edition, which serves as a guide to agencies creating a new brand, redesigning an existing brand, or striving to improve their brand messaging.   About Home Care Ops:   Home Care Ops offers resources, templates, operational methodologies, and training for every leadership level. Through easy-to-follow courses, information-packed webinars, and Summits with some of the greatest minds across any industry, owners and operators can stop the cycle of reaction and start taking true control over their business's success. Our team strives to help home care owners solve more problems at every level - Build | Grow | Scale.

Totally Booked: LIVE! In this special episode of the podcast (in-person at the Whitby Hotel with a live audience!), Zibby interviews New York Times bestselling author Amy Bloom about I'LL BE RIGHT HERE, a sweeping multigenerational story that begins in occupied Paris and spans 50 years. She reflects on her signature themes (family, love, sex, and death), the moral complexity of her writing, and her fascination with found families, marginalized characters, and hidden histories. She also touches on the impact of her memoir, IN LOVE, which tells the story of her late husband's Alzheimer's and death.Purchase on Bookshop: https://bit.ly/3IaM7h4Share, rate, & review the podcast, and follow Zibby on Instagram @zibbyowens! Hosted on Acast. See acast.com/privacy for more information.

Episode 25:26 The Signs, Symptoms And Blood Tests That Define Insulin Resistance Believe it or not, there's a really good chance that the cells of your body are Insulin Resistant. That's not good because Insulin Resistance is THE cause of many major chronic conditions. Conditions such as heart disease, fatty liver disease, high blood pressure, stroke, diabetes, cancer, obesity, Alzheimer's, PCOS, erectile dysfunction and infertility. Unfortunately, most doctors know very little about Insulin Resistance. How to identify it or how to treat it. That's not good. The truth is, EVERYONE should know about Insulin Resistance. - What it is. - How to know if you have it. - Steps you can take to reverse it. On this episode I address what Insulin Resistance is and the blood tests you need to have done to see if you have it. It's information that I feel is extremely valuable and should be taught to everyone. So please be sure to give it a good listen and then share it with a friend.  Thanks! ———————- Want to learn more? Continue the conversation regarding this episode, and all future episodes, by signing up for our daily emails. Simply visit: GetHealthyAlabama.com  Once there, download the “Symptom Survey” and you will automatically added to our email list. ———————- Also, if you haven't already, we'd appreciate it if you'd subscribe to the podcast, leave a comment and give us a rating. (Thanks!!!)  On Facebook? Connect with us at Facebook.com/GetHealthyAlabama

               * This podcast is for informational and educational purposes only. It is not intended to diagnose or treat any disease. Please consult with your health care provider before making any health-related changes.

Digging into ATP, Glutathione, and more:Scott Mulvaney and Dr. Nyan Patel discuss the benefits of glutathione, a powerful antioxidant crucial for detoxification and overall health. Dr. Patel, a pharmacist with 30 years of experience, explains the challenges of delivering glutathione orally and the success of his patented transdermal glutathione technology. He highlights the importance of maintaining high glutathione levels to combat oxidative stress and prevent diseases like Alzheimer's and Parkinson's. Dr. Patel shares his personal journey and success stories, including his father's significant health improvements after using his product. They emphasize the need for personal health accountability and the potential of glutathione to enhance brain function and athletic performance. Nayan Patel shared the story of his father, who at 84 underwent double knee replacements and quickly recovered, walking out of the hospital two days post-surgery. Despite being advised to rest, his father traveled extensively, including to India and Africa. Despite a fall resulting in a skull fracture and internal bleeding, his father remained positive and resilient. Nayan emphasized the importance of mindset and glutathione supplementation, which he believes played a crucial role in his father's recovery. He also discussed the broader impact of his work, aiming to help millions through his company, Auro Wellness, and his book, "The Glutathione Revolution."Quote: Fight Disease, Slow Aging, and Increase Energy with the Master Antioxidant! ~ Dr. Nayan Patel Your Co-Host Today:DR. NAYAN PATEL is a sought after pharmacist, wellness expert, and thought leader in his industry. He has been working with physicians since 1999 to custom develop medication for their clients and design a patient specific drug and nutrition regimen. He has been the pharmacist of choice to celebrities, CEOs and physicians themselves. He recently published his first comprehensive book, The Glutathione Revolution: Fight Disease, Slow Aging & Increase Energy. After 11 years of clinical research on the master antioxidant, glutathione, Dr. Patel and his team developed a patented technology to deliver Glutathione topically, changing the game on how best to absorb GSH systemically. From this technology he additionally developed The Auro GSH Antioxidant Delivery System to create a skincare line to deliver antioxidants more efficiently and effectively than ever before at potent concentrations. Today's Top 3 Takeaways:The topical delivery method of glutathione is far superior to oral, consumable, IV forms of delivery. Positive healthy impacts of glutathione use again oxidative stress, brain fog, neuroplasticity, cellular repair, and more. The benefits of serving yourself as an N-1 experiement, investing in functional medicine, regular blood work anlysis, and more. Today's Guest Co-Host Links:https://aurowellness.com/https://www.instagram.com/Aurowellness/https://www.facebook.com/aurowellnesshttps://www.tiktok.com/@auro.wellnesshttps://www.youtube.com/@aurowellness Watch us on YouTube:

Newsflash! Private detective A-I is on the Alzheimer's case!

Send us a textIn this first episode of our new series, The Real Thing, we confront a subtle but powerful lie many of us have believed: that following Jesus means managing our lives better. From color-coded binders to constant striving, we've both fallen into the trap of believing that more control equals more freedom. But Jesus didn't come to help us manage our sin—He came to give us life to the full. That doesn't mean a perfect life, but a deep, soul-satisfying connection with Him that begins now.We share personal stories of how “management mode” drained us—Heidi in her struggles with fear-driven weight control, and Christina in the midst of her mom's Alzheimer's journey, where surrender brought surprising peace. We're learning that true freedom comes not through tighter grip, but through trust. We close with simple breath prayers and practical steps to help you move from self-reliance to relationship. You were made for more than managing—you were made for real life with God.Support the showLearn more about our Revelation Within Community: https://www.revelationwithin.org

Steve and Virginia sit down with Andrea Hughes, a dedicated caregiver whose mother was diagnosed with early-onset Alzheimer's Disease. Featured in the PBS documentary Matter of Mind: My Alzheimer's, Andrea shares her personal journey navigating the challenges of caregiving at a young age, balancing work and family responsibilities, and finding strength through community and storytelling. To learn more, visit the PBS documentary page, follow Andrea on Instagram @itsandreakrystal, and explore her work at candidcaregiverscollective.com.

Creatine, Brain Health, And Alzheimer's: The Research, Explained “A new pilot study on creatine and Alzheimer's disease has caused a stir in the science, health, and wellness circles of social media, with many viral videos making bold claims like “creatine reverses memory loss” or “creatine reduces the risk of dementia. But what does the science actually show?” By Dr Ayesah Sherzai at @thebraindocs. #vegan #plantbased #plantbasedbriefing #braindocs #creatine #alzheimers #dementia #cognitivedecline ===================== Original post: https://thebraindocs.com/creatine-alzheimers-study-explained/  ===================== Ayesha and Dean Sherzai are co-directors of the Alzheimer's Prevention Program at Loma Linda University. They're both practicing neurologists, scientists, authors, parents, and a husband and wife duo that know the value of healthy lifestyle choices and they've  seen the impact that their NEURO Plan framework has in making the sick healthy and in taking healthy to the next level.  They met as young physicians and in their first conversation learned that both of their grandparents had spent their remaining days on this Earth suffering from dementia. They vowed to do whatever they could to help others avoid this fate and build healthy minds and bodies. They conduct research, treat patients, and serve as professors at Georgetown University, Columbia University, the National Institutes of Health, Mount Sinai, and Loma Linda University, where they serve as the co-directors of The Alzheimer's Prevention Program. They've worked with devastatingly disease-ridden populations and some of the healthiest people in the world – the Loma Linda 7th Day Adventist population (a Blue Zone community, defined by living measurably longer and healthier lives due to optimal nutrition, exercise, stress management, and social support.) ============================= FOLLOW THE SHOW ON: YouTube: https://www.youtube.com/@plantbasedbriefing     Spotify: https://open.spotify.com/show/2GONW0q2EDJMzqhuwuxdCF?si=2a20c247461d4ad7 Apple Podcasts: https://podcasts.apple.com/us/podcast/plant-based-briefing/id1562925866 Your podcast app of choice: https://pod.link/1562925866 Facebook: https://www.facebook.com/PlantBasedBriefing   LinkedIn: https://www.linkedin.com/company/plant-based-briefing/   Instagram: https://www.instagram.com/plantbasedbriefing/   

Alzheimer's disease is one of the most challenging diagnoses for patients, families, and caregivers alike. With cases on the rise globally, the urgency to better understand, detect, and treat this complex brain disorder has never been greater. In this episode, our host Cathy Wurzer, explores the latest research breakthroughs that are offering new hope in the fight against Alzheimer's with Amy Goldman, CEO & Chair of GHR Foundation; Dr. Vijay Shah, Executive Dean of Research at Mayo Clinic and Heidi Dieter, Chair at the Mayo Clinic Department of Research Administration. Get the latest health information from Mayo Clinic's experts, subscribe to Mayo Clinic's newsletter for free today:  https://mayocl.in/3EcNPNc

Dr. Jay Anders, Chief Medical Officer at Medicomp Systems, discusses the issue of dirty data — inaccurate and inconsistent medical data — and its origins, as well as how technology can be used to maintain correct health records. These kinds of errors can lead to incorrect diagnoses, inappropriate treatment, and negative consequences for patients, providers, and payers. AI and other technologies are being leveraged to help identify and flag inconsistencies, providing stakeholders with the tools to prioritize accuracy over efficiency.  Jay explains, "What we do at Medicomp is a clinical knowledge engine with a knowledge graph that's built in that helps clinicians document, sort data, and clean up data. That engine was developed 46 years ago, and it's been done over again in different iterations for those 46 years. We're now incorporating new technologies inside of it to make it more efficient. But we handle medical data in documentation, presentation, and cleanup."   "Well, dirty data has been around since physicians got a chisel and a hammer and etched it in a rock. Because if you think about the old days of dictation, when physicians didn't follow what they dictated or read it very carefully, things got into that medical record that may or may not be correct.  What I mean by dirty data is, does the documentation of that patient's data actually represent what's going on with the patient?" "The other thing that happens, and it's happening more now with ambient listing technologies and other things, is that a family history of a terminal disease will all of a sudden be applied to the patient that's in front of you. So my father had Alzheimer's, now I have Alzheimer's, and it gets into the medical record that way. Gender changes. I have seen this back in the days of dictation, where he turns to her and back and forth again in the same note, which is obviously not correct. So when I say dirty data, that's the kind of thing I'm talking about. Basically, it's incorrect or misconstrued, and it gets propagated through the medical record, and with interoperability, that medical record tends to follow you everywhere you go now, and getting rid of some of that is a daunting task at best."  #Medicomp #MedAI #MedicalRecords #PatientInformation #EHR medicomp.com Listen to the podcast here

Dr. Jay Anders, Chief Medical Officer at Medicomp Systems, discusses the issue of dirty data — inaccurate and inconsistent medical data — and its origins, as well as how technology can be used to maintain correct health records. These kinds of errors can lead to incorrect diagnoses, inappropriate treatment, and negative consequences for patients, providers, and payers. AI and other technologies are being leveraged to help identify and flag inconsistencies, providing stakeholders with the tools to prioritize accuracy over efficiency.  Jay explains, "What we do at Medicomp is a clinical knowledge engine with a knowledge graph that's built in that helps clinicians document, sort data, and clean up data. That engine was developed 46 years ago, and it's been done over again in different iterations for those 46 years. We're now incorporating new technologies inside of it to make it more efficient. But we handle medical data in documentation, presentation, and cleanup."   "Well, dirty data has been around since physicians got a chisel and a hammer and etched it in a rock. Because if you think about the old days of dictation, when physicians didn't follow what they dictated or read it very carefully, things got into that medical record that may or may not be correct.  What I mean by dirty data is, does the documentation of that patient's data actually represent what's going on with the patient?" "The other thing that happens, and it's happening more now with ambient listing technologies and other things, is that a family history of a terminal disease will all of a sudden be applied to the patient that's in front of you. So my father had Alzheimer's, now I have Alzheimer's, and it gets into the medical record that way. Gender changes. I have seen this back in the days of dictation, where he turns to her and back and forth again in the same note, which is obviously not correct. So when I say dirty data, that's the kind of thing I'm talking about. Basically, it's incorrect or misconstrued, and it gets propagated through the medical record, and with interoperability, that medical record tends to follow you everywhere you go now, and getting rid of some of that is a daunting task at best."  #Medicomp #MedAI #MedicalRecords #PatientInformation #EHR medicomp.com Download the transcript here

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/CEH865. CME/AAPA credit will be available until July 3, 2026.Alzheimer's Disease Neuroradiology Case Conference: Mastering the New Frontier in Diagnosis and Treatment In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

 Nuestro economista de cabecera, Santiago Niño Becerra, analiza la actualidad económica en 'La Ventana de los Números'. Guillermo Martín, conocido como Farmaenfurecida, habla de los bulos sobre la salud más virales. Hablamos con José María Frade, investigador del Instituto Cajal del CSIC, sobre la búsqueda de la cura del Alzheimer en el ojo de un pollo. 

Did you know you can detect Alzheimer's risk in your 20s with a simple blood test? In this Habits and Hustle episode, I sit down with Dr. Dale Bredesen, the first scientist to successfully reverse Alzheimer's disease. We explore the three major causes of cognitive decline, why your brain fog might be pre-Alzheimer's, and the shocking truth about everyday toxins like sushi, hair dye, and microplastics. We also dive into the KetoFlex 12-3 protocol and why 45 million Americans are headed for Alzheimer's. From sleep apnea's brain damage to the surprising benefits of saunas and cold plunges, this episode transforms everything you thought you knew about brain health. Dr. Dale Bredesen is an internationally recognized expert in neurodegenerative diseases and creator of the ReCODE Protocol™. He earned his M.D. from Duke University, served as founding President and CEO of the Buck Institute, and is author of the New York Times bestseller The End of Alzheimer's. What We Discuss:  (01:00) - Reversing Alzheimer's (14:53) - Toxins and Brain Health (21:31) - Brain Health and Sleep Quality (36:01) - Toxins and Dietary Choices (41:16) - Optimizing Brain Health Through Lifestyle (50:55) - Reversing Inflammation and Brain Decline (58:23) - Toxins, Mitochondria, and Cognitive Health (01:19:40) - Differentiating Dementia From Alzheimer's (01:23:59) - Achieving Optimal Brain Health Through Diet (01:27:50) - Restoring Brain Energy With Ketones …and more! Thank you to our sponsors: Momentous: Shop this link and use code Jen for 20% off Therasage: Head over to therasage.com and use code Be Bold for 15% off  TruNiagen: Head over to truniagen.com and use code HUSTLE20 to get $20 off any purchase over $100. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. Bio.me: Link to daily prebiotic fiber here, code Jennifer20 for 20% off.  David: Buy 4, get the 5th free at davidprotein.com/habitsandhustle.   Find more from Jen:  Website: https://www.jennifercohen.com/ Instagram: @therealjencohen   Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagement Find more from Dr. Dale Bredesen: Website: https://www.apollohealthco.com/dr-bredesen/  Instagram: https://www.instagram.com/apollohealthco/

You're going to want to listen to this one! We're answering all the hard questions about creatine with one of the top researchers in the industry, Dr. Darren Candow! We cover popular myths, how to figure out your exact dose, troubleshooting issues like bloating and sleep issues, and talk about the latest in the evidence-based literature. Let's geek out!Timestamps:[1:37] Intro[4:28] Conversation with Dr. Darren Candow[5:24] What has happened in the literature in the past few decades that's gotten people talking so much about creatine and supplementing with it?[6:41] How does creatine actually support lean body mass, exercise performance, and every day activities?[13:13] If somebody's completely new to creatine, where do they start with dosage and timing?[17:18] Do men and women need the same amount of creatine or does weight and muscle mass determine how much a person needs?[19:18] Should you maintain the 3-5 grams dose for someone working out a few times a week?[27:42] Is there any benefit in taking creatine pre-workout vs. post-workout, and why we should note our caffeine intake?[31:57] Do you need to cycle creatine, and if so, what's a good schedule?[32:41] Can creatine support health and bone density for people going through perimenopause and menopause? [38:43] What does the data say about creatine use for children and teens?[42:41] Is creatine safe to use during pregnancy and breastfeeding?[47:29] Are there any contraindications that should avoid creatine if you have a pre-existing condition?[48:56] Does creatine cause hair loss in men?[50:15] Why is bloating so common, and if someone is experiencing thing, what should they do? [51:29] Does our water consumption need to increase when taking creatine?[52:23] Can creatine cause muscle cramping?[53:01] Can taking creating help with PMS symptoms in women?[53:56] A popular biohacker says creatine is bad for fertility - is there any credence to that perspective? [54:43] Can you take creatine if you have stage 1 kidney disease but are asymptomatic?[55:59] I was using creatine monohydrate for a few weeks but had joint pain and swelling - is that related?[56:30] I'm noticing that if I have creatine in the afternoon I have trouble sleeping - can that be the case?[58:54] I break out when taking creatine and it clears up when I stop. Is there anything specific I can do?[59:44] Should someone who's prone to rhabdo take creatine?[1:00:34] I recently saw a study related to improved cognition in Alzheimer's that creatine was 5x the normal does. Episode Links:Follow Dr. Darren on InstagramGet Pure Creatine hereRelative method: 0.1g of creatine per kgCaffeine dose is less than 300mgSponsors:Go to https://thisisneeded.com/  and use coupon code WELLFED for 20% off your first order.Go to boncharge.com/WELLFED and use coupon code WELLFED to save 15% off any order.Go to mdlogichealth.com/defend and use coupon code WELLFED for 10% off.Go to wellminerals.us/creatine and use code WELLFED to get 10% off your order.

It's clear that artificial intelligence is going to be one of the most powerful forces shaping the future of humanity and the planet today and over the next two decades. Much of the AI discourse is negative or dystopian themed. Far too little AI news is highlighting how the planet's problems and the challenges humans face can be solved. In this conversation, futurist Jack Uldrich paints a picture of how we can collectively benefit from the advancements in artificial intelligence. Given the moving target of forecasting the future, Jack provides AI scenarios that he is 99% certain will occur, 75% certain, and 50% certain. He even provides a few scenarios that have a 25% and even 1% chances of happening. Jack says that we will see great leaps in diagnosing cancer and Alzheimer's Disease sooner. He is optimistic that AI can be used to address the effects of climate change and greatly assist in the pursuit of nuclear fusion. In what is becoming known as the “compressed century” - where there will be a century's worth of change in just a decade, Jack points out that “AI is doubling in capacity and capability every seven months” which means that the capabilities of AI in six years could be a thousand times more powerful than they are today. Jack doesn't see AI as a panacea. He points out that there will be job losses because of AI. He says that trust could be further eroded as a result of AI-generated deep fakes and fake news. He also points out that the “internet is broken” as we move from “social media to social production.” The conversation ends with Jack sharing his ideas around how purpose, faith, and trust will grow in importance to cope with the disruption AI is certain to bring. Jack Uldrich is a well-recognized global futurist, speaker, and the author of thirteen books, including a number of award-winning best sellers. He is a frequent speaker on technology, change management and leadership and has addressed hundreds of corporations, associations and not-for-profit organizations on five continents. He regularly makes television appearances on PBS's Frontline, the Science Channel, and the Discovery Channel, and is a frequent guest on major media outlets, including CNN, CNBC, Fox and National Public Radio.

Jason and Paul return to their Playlist series with the ongoing protests around America as the context. Pearl Jam have always been champions of the oppressed, activists with a catalog to match...so which songs compiled would make the best EP for standing one's ground?Please considering donating to our June 2025 fundraiser benefitting Alzheimer's Association HEREBuy Pod MerchBecome a PatronWatch Us on YouTubeFollow Us on InstagramFollow Us on FacebookFollow Us on Twitter Hosted on Acast. See acast.com/privacy for more information.

Navigating dementia care can be overwhelming. Traditional healthcare systems often fall short, leaving families without adequate support. However, a significant shift is underway. The federal government has launched GUIDE, a program acknowledging nationwide gaps in dementia care. This innovative initiative sets new standards, urging healthcare systems to adopt a different approach. We delve into the future of dementia care, exploring scalable, specialized solutions. Furthermore, we uncover how expert teams, like Remo Health's, provide comprehensive support for both patients and caregivers. This includes virtual clinical care, evidence-based education, and a vital community network. Additionally, proactive risk identification and on-demand access are becoming crucial. This model offers cost-effective, deeply personalized support. Moreover, it aligns perfectly with GUIDE's call for fundamental change. Tune in to discover how this new era promises better outcomes and essential assistance. Our Guest: Sabrina Chugani Sabrina is a co-founder and Chief Growth Officer at Remo Health, where she oversees partnerships, marketing, and account management. Sabrina has deep expertise in value-based care and has spent her career working at the forefront of innovative payment models, including MSSP, CKCC, and Direct Contracting, that change the way care is delivered nationwide. About Remo Health Remo Health is a virtual dementia care company. Our world-class neurologists diagnose and manage all types of dementia. Remo provides peer support, comprehensive and personalized care plans, and 24/7 access to experts for people living with dementia and those who care for them. Remo Health is a trusted participant in the Centers for Medicare & Medicaid Services' Guiding an Improved Dementia Experience (GUIDE) Model. ++++++++++++++++++++++++++++++++++++++++ Related Episodes: Brain Rejuvenation: Stem Cell Therapy and Alzheimer's Disease The Brain's Fountain of Youth: Innovative Paths to Dementia Prevention ++++++++++++++++++++++++++++++++++++++++ Sign Up for more Advice & Wisdom - email newsletter. Please help us keep our show going by supporting our sponsors. Thank you. ++++++++++++++++++++++++++++++++++++++++ Make Your Brain Span Match Your LifeSpan Relevate from NeuroReserve With Relevate nutritional supplement, you get science-backed nutrition to help protect your brain power today and for years to come. You deserve a brain span that lasts as long as your lifespan. ++++++++++++++++++++++++++++++++++++++++ Feeling overwhelmed? HelpTexts can be your pocket therapist. Going through a tough time? HelpTexts offers confidential support delivered straight to your phone via text message. Whether you're dealing with grief, caregiving stress, or just need a mental health boost, their expert-guided texts provide personalized tips and advice. Sign up for a year of support and get: Daily or twice-weekly texts tailored to your situation Actionable strategies to cope and move forward Support for those who care about you (optional) HelpTexts makes getting help easy and convenient. ++++++++++++++++++++++++++++++++++++++++ List of the Top 20 Alzheimer's Podcasts via FeedSpot! See where we rank. Join Fading Memories On Social Media! If you've enjoyed this episode, please share this podcast with other caregivers! You'll find us on social media at the following links. Instagram LinkedIn  Facebook Contact Jen at hello@fadingmemoriespodcast.com Or learn more at Our Website

When someone with Alzheimer's gets upset about something that isn't actually happening, it can be easy to dismiss their feelings. But what if we approached those feelings not as problems to get rid of, but mysteries to solve? In this bonus episode, psychologist Claudia Drossel unpacks the feelings of people with Alzheimer's and how to decode them to use as a guide to give better care.To listen to the full bonus episode, sign up to become a Patreon member. You'll get ad-free episodes, monthly exclusive bonus interviews, and other goodies.From the episode:  Learn more about Claudia Drossel's work at Eastern Michigan University Caregiving resources from Claudia Sign up for our free newsletter. Follow us on Instagram: @proxypodcast @yoweishawGet in touch at proxythepod@gmail.com

In this episode, you'll learn the 10 most important things to know about APOE4, including its connection to Alzheimer's disease, heart disease, and stroke. Dr. Robert Todd Hurst, MD, FACC, FASE shares proven prevention strategies, lifestyle interventions, and cutting-edge technology to help you take control of your cognitive and cardiovascular future.  Key Time Stamps:  00:30 – What APOE4 is and what you will learn here today  01:15 – What does APOE4 mean, Alzheimer's and heart disease risks   02:05 – How dementia risk is growing and how genetics play a role  02:30 – How do you get APOE4 carrier and should you be screened  02:55 – Dementia may be preventable, what the science says  03:55 – The FINGER Trial and how lifestyle changes can improve brain function  04:30 – What's coming next in dementia prevention research  05:18 – A 15-minute cognitive assessment using eye-tracking technology  08:17 – APOE4 and your risk for heart disease and stroke  08:40 – Why waiting for symptoms is no longer an option  09:25 – What's included in the Cognitive Enhancement Program at HealthspanMD  10:35 – Why a team of experts is the path we take at HealthspanMD  12:25 – Why this is not just a checkup, but a strategy for long-term health  13:55 – How to take the first step toward protecting your future  This information is for educational purposes only and is not medical advice. Don't make any decisions about your medical treatment without first talking to your doctor.    Connect with HealthspanMD:  https://www.linkedin.com/company/healthspanmd/   https://www.facebook.com/healthspanmd   https://www.instagram.com/healthspanmd/  https://quiz.healthspanmd.com/    

The Risk of Alzheimers

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter BJ Miller, a hospice and palliative care physician, and Bridget Sumser, a licensed social worker specializing in serious illness and end-of-life care, join Peter to share insights from their decades of work supporting people at the end of life. In this episode, they explore the emotional and physiological processes of dying, the cultural barriers that prevent meaningful conversations about death, and how early engagement with mortality can lead to greater clarity and connection. The conversation highlights the distinctions between hospice and palliative care, the nature of suffering beyond physical pain, and the transformative role of honesty, forgiveness, and relational awareness in the dying process. Through stories and reflections, BJ and Bridget reveal what truly matters in the end—and how the dying can teach the living not only how to face death but how to live more fully. We discuss: The personal journeys of BJ and Bridget into end-of-life care, and the connection between living and dying [3:30]; What dying looks like: the physical, cognitive, and emotional realities at the end of life [13:15]; How historical perspectives on death contrast with modern experiences of dying [25:30]; The difference between palliative care and hospice care [30:45]; The systemic challenges surrounding hospice care: why patients often enter it too late to receive its full benefits [35:30]; How delayed hospice referrals and unspoken preferences often prevent patients from dying where and how they truly want [39:30]; The realities of home hospice: challenges, costs, and burdens placed of families [43:45]; How proactively engaging with the reality of death can avoid unnecessary suffering and promote a more peaceful ending [53:30]; How palliative care is misunderstood and underutilized—especially in cancer care [1:02:45]; Palliative care in the case of Alzheimer's disease: emotional support, future planning, and family involvement [1:12:15]; The importance of having an advance directive: defining what matters most before it's too late [1:23:00]; The differences between how young and old individuals experience dying from cancer [1:30:15]; The difference between pain and suffering, role of medicine in pain relief, and why emotional healing is essential at the end of life [1:35:45]; Dying well: the power of self-honesty and human connection at the end of life [1:47:00]; How psychedelics like psilocybin can unlock emotional breakthroughs and deepen connection for patients near the end of life [1:55:15]; Lessons from the dying on how to live well [1:57:30]; The physical process of active dying, and the emotional and practical considerations for loved ones [2:09:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

What if we could delay--or even prevent--Alzheimer's, cancer, and heart disease? What if much of what you know about aging is wrong? Listen as cardiologist and author Eric Topol of the Scripps Research Institute talks about his new book Super Agers with EconTalk's Russ Roberts. They discuss why your genes matter less than you think, how your immune system can help prevent cancer and Alzheimer's, and why a simple shingles vaccine could reduce the risk of dementia. From the surprising anti-inflammatory powers of Ozempic to the critical importance of deep sleep for brain detoxification, Topol shares insights that can extend your healthy lifespan.

All Home Care Matters and our host, Lance A. Slatton were honored to welcome Dr. Rob Winningham the Co-Author of the Cranium Crunches Workbook by Activity Connection.   About Dr. Rob Winningham:   Dr. Rob Winningham received his Ph.D. in neuroscience from Baylor University. He joined the faculty at Western Oregon University in 2000 where he serves as a Professor of Psychological Sciences and Gerontology. He helped create the Gerontology Department, when he was Division Chair of the Behavioral Sciences Division. And, he has served as College Dean, Provost and Vice President for Academic Affairs at Western Oregon University. His scholarship and publications have generally focused on maximizing older adults' quality of life, cognitive stimulation, physical activity, intergenerational programs, and social engagement throughout the lifespan.   In addition to publishing many peer-reviewed scientific articles, Dr. Winningham has been invited to give nearly 2000 presentations at various conferences, workshops and community settings. He has participated in the development of a number of popular products for senior living and healthcare, including LinkedSenior, SMARTfit, and resources available through Activity Connection.   His book, Train Your Brain: How to Maximize Memory Ability in Older Adulthood was published by Routledge Publishing and his latest book, co-written by Nancy Ewald, is entitled Cranium Crunches, both books can be found on Amazon.   About Activity Connection:   Activity Connection is a trusted leader in life enrichment programming, serving nearly 20,000 senior living communities. Each month, the platform delivers over 400 original, high-quality resources across nearly 40 categories—including themed activities, crafts, games, trivia, reminiscence programs, Montessori-based engagement, lifelong learning, virtual travel experiences, holiday celebrations, and more.   While many programs are designed for broad community engagement, versions of select activities are specially created for those in memory care. These thoughtfully developed resources help promote connection and purpose for residents at varying ability levels. Many also encourage intergenerational engagement, providing meaningful opportunities for families and volunteers to participate.   All content aligns with person-centered care standards and complies with state regulations—empowering activity professionals and caregivers with tools that are not only engaging, but deeply enriching for our aging loved ones.

Welcome to episode 300! In this eye-opening episode, we dive into the latest cutting-edge research shaking up the wellness world. First, we explore how creatine—a supplement long known for its fitness benefits—is showing promise in combating Alzheimer's disease, potentially offering a new line of defense for cognitive decline. We also unpack emerging research linking Parkinson's disease to pesticides commonly found on golf courses, raising important questions about environmental exposure and neurodegeneration.The conversation then shifts to our latest biohacking experiments, including the use of Delta Sleep Inducing Peptide (DSIP) to improve deep sleep, the powerful ingredient paraxanthine as a cleaner caffeine alternative, and even the overlooked practice of coffee enemas for detoxification and mental clarity.The episode wraps with a deep dive into cycle syncing, a popular but often misunderstood strategy for aligning lifestyle choices with the menstrual cycle. We break down the biological reasoning behind syncing your workouts, diet, and supplements with each phase of the cycle. We separate fact from fiction, tackle common myths, and discuss both the pros—like optimized energy and hormonal harmony—and cons, including potential over-complication and the risk of becoming overly rigid.Whether you're a seasoned biohacker or just curious about the intersection of science and wellness, this episode delivers a potent mix of science-backed insights, personal experimentation, and myth-busting clarity.SHOW NOTES:0:39 Welcome to the podcast!3:19 Creatine for Alzheimer's7:12 Golf courses & Parkinson's11:45 Coffee enemas19:11 Delta-Sleep-Inducing Peptide20:24 Gupta Program22:45 Timeline nutrition25:52 Paraxanthine x UPDATE27:26 Lauren's Red Light stack28:32 **ALIGN MAT*30:31 Hack for back pain31:49 Cycle Syncing headline36:14 Benefits of cycle syncing39:46 Supporting muscle protein synthesis43:01 Tracking your menstrual cycle47:02 Is Cycle Syncing a trend?49:32 Thanks for tuning in for 300!RESOURCES:Creatine: Kion - code: biobabes15 & Puori - code: biohackerbabesPompa Program Cellular DetoxHappy Bum Coffee Enema Kit - Discount code: BIOHACKERBABESGupta ProgramLimbic Retraining: Primal Trust, DNRSTimeline Nutrition - code: BIOHACKERBABESDrink UpdateAlign Mat - code: BIOHACKERBABES to save $250 OURA RingOur Sponsors:* Check out Puori: https://Puori.com/BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands