Podcasts about alzheimer's disease

“We can choose our brain's destiny,” says David Perlmutter, MD. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, and brain health. He is on the Board of Directors of the American College of Nutrition and the Editorial Board of the Journal of Alzheimer's Disease. His books, including the #1 bestseller Grain Brain, has been published in 32 languages and sold over a million copies. Perlmutter lectures globally at leading institutions and has been featured on major media outlets including 20/20, CNN, The Today Show, and Oprah. His new book, Brain Defenders, focuses on the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience, and is now available for pre-order. 00:00 - Treating the symptoms, not the cause  02:37 - Microglial cells & their evil twin state  05:44 - How metabolism affects the brain  08:00 - Gut bacteria, inflammation, & brain degeneration  11:38 - Why lifestyle beats the APOE4 gene  16:25 - Perlmutter's daily routine 23:55 - Loneliness & oxytocin  26:21 - The effects of long COVID on the brain 32:18 - Glyphosate & other environmental factors  39:20 - Reprogramming microglia & mitochondrial transplants  41:35 - Own your brain's destiny Referenced in the episode:  For more about Perlmutter, visit his website: https://drperlmutter.com/  Alzheimers & UPFs study: https://doi.org/10.1016/j.tjpad.2024.100042  POINTER study - https://jamanetwork.com/journals/jama/fullarticle/2837046  20-week Alzheimer's study:  https://link.springer.com/article/10.1186/s13195-024-01482-z  Golf course & Parkinson's study: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

PhenoNet Cleared By FDA To Begin Phase 3 Trial Of Inhaled Alzheimer's Drug PhenoNet has received FDA clearance to begin a Phase 3 trial of PHENOGENE-1A, an inhaled formulation of cromolyn sodium, an asthma drug with decades of safety data. Unlike most Alzheimer's therapies, which target only APOE4 gene carriers, this ~648-person trial stratifies both carriers and non-carriers by genotype, testing whether reducing amyloid aggregation, inflammation, and microglial dysfunction can benefit a broader Alzheimer's population than current treatments reach. Host Dave Asprey explains why this genotype-inclusive design challenges the field's narrow focus on APOE4 carriers, and what it means for families with Alzheimer's history who don't carry the gene. Sources: https://www.morningstar.com/news/business-wire/20260813649121/phenonet-cleared-by-fda-to-begin-phase-3-trial-of-inhaled-phenogene-1a-in-early-alzheimers-disease https://www.businesswire.com/news/home/20260813649121/en/ https://www.phenonet.us ~~~University Of Zurich Researchers Discover The Adult Brain Can Repair Itself Better Than Believed Researchers at the University of Zurich identified a population of "regenerative astrocytes" in living mouse brains that repair damaged tissue through a previously unknown mechanism: dividing cells send newly formed nuclei traveling across long cellular extensions to repopulate injured regions and rebuild the astrocyte network. The discovery overturns the long-standing assumption that adult brains have limited capacity to replace lost astrocytes after injury or autoimmune disease. Host Dave Asprey unpacks why this finding reframes brain injury recovery as something the body may already be equipped to handle, and what the newly identified genetic pathways could mean for future regenerative therapies. Sources: https://www.news.uzh.ch/en/articles/media/2026/regenerative-astrocytes.html https://www.sciencedaily.com/releases/2026/08/260812015158.htm https://www.eurekalert.org/news-releases/1139114 https://www.nature.com/articles/s41593-026-02354-5 ~~~Sheep's Wool-Derived Keratin Outperforms Collagen In Bone Regeneration Study Researchers at King's College London developed a keratin scaffold from sheep's wool, a farming industry waste product, and tested it against collagen, the current gold standard, in rats with non-healing skull defects. While collagen produced more total bone volume, the keratin scaffold generated bone that was more structurally organized and closer to natural bone architecture, while remaining stable and integrating cleanly with surrounding tissue. Host Dave Asprey explains why bone quality, not just quantity, matters for weight-bearing repair, and why a cheaper, more sustainable material outperforming the standard is a bigger deal than it sounds. Sources: https://medicalxpress.com/news/2026-04-scientists-wool-bone-material.html https://www.sciencedaily.com/releases/2026/08/260812015210.htm https://www.ivanhoe.com/news_flash/scientists-turn-sheeps-wool-into-a-material-that-helps-regrow-bone-click-here/ ~~~Oral GLP-1 Pill Aleniglipron Shows 12% Weight Loss In Phase 2b Trial Structure Therapeutics' oral small-molecule GLP-1 receptor agonist, aleniglipron, produced up to 12.1% weight loss at 36 weeks in a 230-person Phase 2b trial, with no apparent plateau and continued loss to 16% in the open-label extension, putting an oral pill in the same efficacy range as injectable GLP-1 drugs like Wegovy and Ozempic. Host Dave Asprey weighs the compliance advantage of an oral option against his ongoing concerns about muscle loss, rebound weight gain, and the fact that GLP-1 drugs treat a symptom rather than the underlying metabolic cause. Sources: https://pubmed.ncbi.nlm.nih.gov/42249138/ https://www.nature.com/articles/s41591-026-04476-6 https://ir.structuretx.com/news-releases/news-release-details/structure-therapeutics-announces-publication-nature-medicine/ https://www.fiercebiotech.com/biotech/structure-touts-16-weight-loss-aleniglipron-highest-efficacy-oral-glp-1 ~~~Study Finds 150 Minutes Of Weekly Exercise Falls Far Short Of Real Heart Protection A Macao Polytechnic University analysis of over 17,000 UK Biobank participants found that the standard 150-minute weekly exercise guideline only reduces cardiovascular risk by 8-9%, while achieving a substantial risk reduction of over 30% requires 560-610 minutes a week, three to four times current recommendations. Only 12% of participants hit that higher threshold. Host Dave Asprey breaks down why public health minimums are a floor, not an optimization target, and what listeners serious about cardiovascular protection should actually be aiming for. Sources: https://medicalxpress.com/news/2026-05-real-heart-weekly-climbs-current.html https://www.medicalnewstoday.com/articles/560-610-minutes-weekly-exercise-lower-cardiovascular-risk-heart-health https://bjsm.bmj.com/content/early/2026/05/19/bjsports-2025-111351 ~~~New Research Clarifies The Mechanism Behind IV Vitamin C's Anti-Cancer Effect Decades after Linus Pauling's high-dose vitamin C claims were dismissed following failed oral-dose trials, researchers have clarified that Pauling had the mechanism right and the delivery method wrong: IV vitamin C bypasses gut absorption limits to reach plasma concentrations up to 100 times higher than oral dosing, generating hydrogen peroxide that is selectively toxic to cancer cells due to their lower catalase levels. A 2024 University of Iowa study found IV vitamin C combined with chemotherapy doubled overall survival in advanced pancreatic cancer patients. Host Dave Asprey reflects on how this vindicates a decades-old idea that was dismissed for the wrong reasons, and what it means for anyone facing a cancer diagnosis. Sources: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01182/full https://www.cancer.gov/about-cancer/treatment/cam/hp/vitamin-c-pdq https://medicine.uiowa.edu/news/2024/11/high-dose-iv-vitamin-c-plus-chemotherapy-doubles-survival-advanced-pancreatic-cancer This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want the latest breakthroughs in neurodegenerative disease, regenerative medicine, metabolic health, and cancer therapeutics, translated into what actually matters for your biology right now. Host Dave Asprey connects clinical trial data, mechanistic research, and decades of context into practical frameworks for taking control of your own health decisions. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: PhenoNet PHENOGENE-1A, inhaled cromolyn Alzheimer's, APOE4 genotype Alzheimer's trial, regenerative astrocytes brain repair, University of Zurich brain regeneration, adult neuroplasticity, keratin bone scaffold, sheep's wool regenerative medicine, collagen vs keratin bone repair, aleniglipron oral GLP-1, Structure Therapeutics weight loss drug, oral semaglutide alternative, exercise minutes cardiovascular risk, 150 minutes exercise guideline, Macao Polytechnic University heart study, IV vitamin C cancer, Linus Pauling vitamin C, ascorbate hydrogen peroxide cancer cells, integrative oncology, biohacking news 2026, Thank you to our sponsors! - Visit www.myvitalc.com/davesfav to unlock Dave's discount - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Alzheimer's Drug Trial 01:43 – Brain Repair Cells 03:07 – Keratin Bone Scaffolds 04:45 – Oral GLP-1 Pill 05:59 – Minimum Effective Exercise 07:26 – IV Vitamin C Revisited 08:12 – Vitamin C Cancer Trial 09:30 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Huberman Lab Essentials episode, my guest is Dr. Sara Gottfried, M.D., a Harvard-trained, board-certified gynecologist and expert in female hormone health. We discuss the key biomarkers women should track at each stage of life and how cortisol, thyroid hormone, estrogen, progesterone, and testosterone shape energy, mood, metabolism, and long-term disease risk. We also discuss PCOS, the risks and benefits of oral contraceptives, and the shift in brain metabolism that begins in perimenopause. Dr. Gottfried explains actionable tools for hormone and micronutrient testing, nutrition, stress management, and cardiometabolic screening that women can use at any age. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (00:00:00) Female Hormone Health (00:00:24) Family History, Intergenerational Trauma; Endometriosis, Fibroids, PCOS (00:01:31) Biomarkers by Decade; Teens & Cortisol; 20s & Sex Hormones (00:03:35) Tool: Hormone Test Timing; Micronutrient Testing, Magnesium (00:05:41) Sponsor: LMNT (00:07:17) Tool: Smoothies, Greens Powders & Microbiome (00:08:12) Nutrient Panels, Antioxidants, B Vitamins, Glutathione (00:09:34) Constipation, Thyroid Dysfunction; Trauma & Female Physiology (00:11:50) Tools: Reduce Perceived Stress, Meditation, Yoga, Breathwork (00:13:30) Opportunities by Decade; Androgens & Testosterone Decline (00:14:50) PCOS, Diagnostic Criteria, Hirsutism, Cardiometabolic Risk (00:17:10) Insulin & Glucose; Tool: Continuous Glucose Monitors (00:18:05) Democratizing Health Data (00:18:52) Sponsor: AG1 (00:20:07) Longevity "Don'ts"; Chronic Cardio & Cortisol; Tool: Adaptive Exercise (00:22:46) Oral Contraceptives, Benefits & Ovarian Cancer Risk (00:24:27) Ovarian Cancer Symptoms, Bloating, CA-125 (00:25:51) Oral Contraceptive Risks, Progestins, Inflammation; SHBG & Testosterone (00:29:08) Clitoral Shrinkage; Tools: Alternatives for Painful Periods (00:30:14) Sponsor: Eight Sleep (00:31:32) Menopause & Perimenopause; 30s Hormonal Baseline (00:33:07) Female Brain, Cerebral Hypometabolism & Alzheimer's Risk (00:35:02) Slow Brain Energy, Hormone Therapy; Hot Flashes as Biomarkers (00:36:54) Tool: Coronary Artery Calcium Score Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

All Home Care Matters and our host, Lance A. Slatton were honored to welcome Dr. Dennis Dulniak, Mark Dulniak, and Craig Dulniak of Nana's Books Foundation for a meaningful conversation about Alzheimer's disease, family caregiving, children's literacy, empathy, and the lasting legacy of Nancy Dulniak.   About Nana's Books Foundation:   Nana's Books Foundation is a nonprofit 501(c)(3) organization dedicated to promoting literacy, empathy, and awareness through the power of books.   The Foundation was created in honor of Nancy Dulniak, a lifelong librarian who passed away from Early-Onset Alzheimer's disease at age 69. Nancy believed books could open minds, inspire compassion, and help children better understand the world around them.   Founded in 2020, Nana's Books Foundation provides age- and grade-appropriate books and educational resources focused on Alzheimer's disease, dementia, disabilities, caregiving, empathy, resilience, and acceptance. Through partnerships with schools, public libraries, and community organizations, the Foundation helps families begin important conversations that can otherwise be difficult to navigate.   Special emphasis is placed on supporting Title I schools and underserved communities.   Since its founding, Nana's Books Foundation has expanded across 16 states and the District of Columbia, distributing more than 26,000 books to nearly 12,000 students and classrooms, as well as 29 school libraries and 20 public libraries.   At its heart, the Foundation carries forward Nancy's lifelong commitment to children, education, libraries, and compassion.   About Dr. Dennis Dulniak:   Dr. Dennis Dulniak is Founder and President of Nana's Books Foundation.   After a 40-year career in higher education, including serving as University Registrar at the University of Central Florida and as a Vice President at Parchment, Dennis became a caregiver when Nancy was diagnosed with Early-Onset Alzheimer's disease in 2014.   For more than seven years, Dennis served as Nancy's care partner, gaining firsthand insight into dementia caregiving, changing relationships, communication, and advocacy.   Following Nancy's passing, he dedicated his retirement to honoring her through Nana's Books Foundation. Dennis is also a Co-Founder of Central Florida Dementia-Friendly Dining, a facilitator and resource for a large men's caregiver support group, and a member of the Central Florida Dementia Care and Cure Initiative.   Today, he shares his family's journey to help caregivers, children, and communities better understand dementia.   About Mark Dulniak:   Mark Dulniak, the eldest son of Nancy and Dennis Dulniak, is Co-Founder and Treasurer of Nana's Books Foundation.   The Foundation's roots began in 2018 when Mark started donating books to Knoxville-area classrooms in honor of his mother. Students wrote thank-you notes to Nancy, bringing her tremendous joy during her journey with Early-Onset Alzheimer's disease.   That tradition eventually grew into Nana's Books Foundation, ensuring Nancy's lifelong love of books and learning would continue to impact future generations.   Mark now helps expand the organization's reach to Title I schools, school libraries, public libraries, students, and families. He also advocates for families to begin age-appropriate conversations with children about dementia, using books as a compassionate way to help them understand what is happening to someone they love.   About Craig Dulniak:   Craig Dulniak, the youngest son of Nancy and Dennis Dulniak, serves as Secretary Emeritus of Nana's Books Foundation and lives with his wife and son in Philadelphia.   During one of Nancy's final visits to Philadelphia, Craig took her to his local public library to sign her grandson up for his first library card at just one year old—a fitting reflection of Nancy's lifelong connection to books and libraries.   Craig hopes Nana's Books Foundation will help children better understand dementia, Alzheimer's disease, disabilities, and caregiving by increasing access to books addressing topics often underrepresented in children's literature.   Through the Foundation, the Dulniak family continues Nancy's legacy through every book shared and every conversation inspired about kindness, empathy, understanding, and inclusion.

Edward Zuckerberg on AI, Dentistry, Oral Health & the Future of HealthcareWhat happens when 50 years of dental experience meets AI, robotics, venture capital, and the future of healthcare?In this episode of Holistic Investments, Constantin Kogan sits down with Dr. Edward Zuckerberg, pioneering dentist, technology adopter, AI advocate, educator, and advisor to entrepreneurs in oral healthcare.Dr. Zuckerberg shares his journey from starting his dental career in Brooklyn to becoming an advocate for transforming dentistry through technology, education, and better integration between oral health and systemic health.

Dr. David Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, and brain health. A Fellow of the American College of Nutrition, he serves on its Board of Directors and on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the #1 bestseller Grain Brain, have been published in 32 languages and sold over a million copies. Dr. Perlmutter lectures globally at leading institutions and has been featured on major media outlets including 20/20, CNN, The Today Show, and Oprah. His contributions have earned him numerous national and international awards for clinical innovation and leadership. Today on the show, we discuss why Alzheimer's may be driven more by lifestyle than genetics, how insulin resistance and blood sugar can quietly damage the brain, the foods and eating habits that may protect cognitive health, why sleep, exercise, and social connection are critical for preventing decline, what caffeine, nicotine, marijuana, and alcohol actually do to the brain, and the simple changes you can start making today to protect your memory for decades to come. Thank you to today's sponsor: Momentous Try Momentous Signature Spec Creatine: https://www.livemomentous.com Use code ADVERSITY for up to 35% off your entire first order Learn more about your ad choices. Visit megaphone.fm/adchoices

HEALTH NEWS Turmeric Extract CLE Improves Orientation and Attention in Middle-Aged Adults, Study Finds Healthy midlife habits linked to longer dementia-free years Industrial Chicken Farming Is Supercharging the Spread of a Dangerous Foodborne Bacterium How folic acid may protect a baby's developing brain and spinal cord Study: Exercise Prompts Liver Enzyme That May Protect Brain Barrier Turmeric Extract CLE Improves Orientation and Attention in Middle-Aged Adults, Study Finds August 10 2026 (Natural News) A 24-week clinical trial published in Frontiers in Nutrition has found that a non-curcumin turmeric extract known as CLE (curcuma longa extract) improved two cognitive functions – orientation and attention – in healthy adults aged 40 to 69. The study tested 35 cognitive measures and reported statistically significant improvements on only two: awareness of time, place and surroundings (orientation) and the ability to focus and ignore distractions (attention). Alzheimer's disease affects about 5.3 million Americans, making it the leading cause of dementia and the sixth leading cause of death in the U.S. The CLE extract tested in this trial contains different compounds – turmeronols A and B and bisacurone – which have shown anti-inflammatory effects in laboratory models. The trial enrolled 40 participants with subtle cognitive changes still considered within the normal range. They were randomly assigned to take either two CLE capsules daily or a placebo for 24 weeks. Cognitive assessments were administered at baseline, at 12 weeks, and at 24 weeks using standard screening tools and an eye-tracking platform. After six months, participants in the CLE group scored higher on orientation compared with the placebo group, according to both an eye-tracking cognitive test and the Montreal Cognitive Assessment – Japanese version (MoCA-J). The CLE group also demonstrated better attention – the ability to focus and ignore distractions – based on the eye-tracking assessment. Healthy midlife habits linked to longer dementia-free years New York University Langone Health, August 6 2026 (News-Medical) Having normal blood pressure, no diabetes, and not smoking from age 48 to 68, are associated with nearly 13 additional years on average of dementia-free life, a new study shows. Led by NYU Langone Health researchers, the new work also found that, no matter how many risk factors they had, women lived longer without dementia than men, and that white study participants had more dementia-free years than Black participants. The findings argue that people need to actively avert these factors in midlife as a strategy for preserving brain health for more than a decade. The current study looked at 12,409 people with an average age of 56 who were free of dementia. Participants were assessed for three risk factors: high blood pressure, diabetes, and smoking. They were then followed for an average of 26 years. Those who had no risk factors lived without developing dementia nearly 13 years longer than people with the three risk factors (30 years total after the study's start versus 17 years). The team also sought to determine how cardiovascular risk factors in midlife influenced dementia-free survival across demographics. Women with all three risk factors lived an average of 18.1 years from the start of tracking without developing dementia, compared to 16.6 years for male study participants. White participants with all three risk factors lived an average of 19.6 years without developing dementia, compared to 16 years for Black participants. Industrial Chicken Farming Is Supercharging the Spread of a Dangerous Foodborne Bacterium Oxford University, August 10, 2026 (SciTech Daily) Commercial poultry farms now hold billions of chickens, creating a vast habitat where bacteria can move, mix and adapt. An analysis from the Ineos Oxford Institute for Antimicrobial Research at the University of Oxford found that industrial poultry production has increased the movement of Campylobacter more than 100 times, allowing strains once associated with wild birds to circulate widely among farmed chickens. Campylobacter is the world's most common bacterial cause of diarrhea. Treatment is also becoming more difficult as antimicrobial resistance (AMR), the ability of bacteria to withstand drugs intended to kill them, continues to rise. Researchers analyzed nearly 2,800 Campylobacter genomes collected from chickens and wild birds in 30 countries (including the UK and USA) between 1979 and 2024. Their study, published in the Proceedings of the National Academy of Sciences (PNAS), indicates that the global growth of chicken production has given different strains more opportunities to spread, exchange genetic material and acquire traits that support survival. Chickens now represent about 70% of all bird biomass on Earth. The findings suggest that enormous, densely packed flocks may function as ecological ‘pathogen sponges,' taking in bacterial strains from different sources and amplifying them. How folic acid may protect a baby's developing brain and spinal cord Hebrew University of Jerusalem, August 11 2026 (Medical Xpress) For more than 30 years, one piece of pregnancy advice has been remarkably consistent: Take folic acid. The reason is clear. Folic acid, or vitamin B9, can lower the risk of neural tube defects, serious birth defects that happen when the early structure that becomes the brain and spinal cord does not close properly. What has been much less clear is how folic acid works. Now, researchers may have found an important part of the answer. In a new study published in the Proceedings of the National Academy of Sciences, scientists discovered that folic acid appears to rely on an enzyme called ALDH1L1. That enzyme helps produce retinoic acid, a powerful developmental signal made from vitamin A. Scientists have long known that folic acid can help prevent many of these defects. But the vitamin seems to be doing more than simply supplying nutrients. The new research suggests that folic acid helps switch on ALDH1L1, a gene that makes the ALDH1L1 enzyme. That enzyme can then help turn a vitamin A-related molecule called retinaldehyde into retinoic acid. Retinoic acid acts like a set of instructions, telling developing cells when to grow, what to become, where to go and when to stop dividing. Study: Exercise Prompts Liver Enzyme That May Protect Brain Barrier University of California at San Francisco, August 10 2026 (Natural News) Researchers at the UC San Francisco Bakar Aging Research Institute have found that exercise prompts the liver to release an enzyme that travels through the bloodstream to the brain and repairs the blood-brain barrier, according to a study published in the journal Cell. The enzyme, called GPLD1, removes a protein called TNAP that accumulates on blood-brain barrier cells over time, the report stated. The findings describe a direct liver-to-brain pathway that partly explains how physical activity protects the brain. The study identified TNAP as a protein that builds up on blood-brain barrier cells over time, according to the researchers. GPLD1 acts to remove TNAP, restoring the barrier's ability to admit nutrients and oxygen while blocking toxins, pathogens, and inflammatory molecules. The findings suggest that consistent, moderate exercise may trigger GPLD1 release, according to the report. Activities such as walking, cycling, and yoga may support cognitive health through this liver-brain connection, the researchers said.       Discussion about this episode

Can changing what you eat treat depression, anxiety, and even psychosis more effectively than medication alone? In this episode of Food Junkies, Dr. Vera Tarman sits down with Dr. Matt Bernstein, MD, psychiatrist and CEO of Accord, to unpack the emerging field of metabolic psychiatry — and what it means for people recovering from food addiction. Dr. Bernstein trained at Columbia, Penn, and the MGH-McLean Psychiatry Program before shifting from traditional hospital-based psychiatric care toward lifestyle-based interventions: nutrition, sleep, light, and movement. He now serves on the advisory board of Metabolic Mind and helped organize the first public conference on metabolic psychiatry in 2023. In this conversation, Dr. Bernstein and Dr. Tarman explore how brain energy metabolism — not just neurotransmitters — may be a root driver of conditions like depression, bipolar disorder, schizophrenia, and Alzheimer's, and why ketogenic and low-carbohydrate approaches are showing early but compelling results for food cravings, food noise, and psychiatric symptom relief. In This Episode, You'll Learn: Why Dr. Bernstein moved away from conventional psychiatric medication models toward metabolic approaches How brain insulin resistance can contribute to depression, bipolar disorder, and schizophrenia The role of mitochondria, oxidative stress, and the gut-brain axis in mental illness How ketones act as an alternative brain fuel — and why that matters for insulin-resistant neurons The connection between brain insulin resistance and Alzheimer's risk decades before symptoms appear How ketogenic and low-carb diets naturally reduce food cravings and "food noise" for people with food addiction What a day in the Accord immersive metabolic psychiatry program actually looks like Why combining diet, exercise, circadian rhythm alignment, and mind-body practices produces faster results than any single intervention alone How GLP-1 medications compare to ketogenic diets for reducing food noise and cravings — and where each may fall short The risks of rapid or unsupported psychiatric medication tapering, and why "hyperbolic tapering" matters What to watch for (and troubleshoot) if a ketogenic diet isn't producing results after several weeks Guest Dr. Matt Bernstein, MD is a psychiatrist and CEO of Accord, an immersive metabolic psychiatry program near Boston. He is a leading voice in metabolic psychiatry, sits on the advisory board of Metabolic Mind, and helped organize the first public conference dedicated to the field in 2023. Connect with Dr. Matt Bernstein & Accord Website: https://accordmh.com/   Releasing What's Not Ours: Healing Food & Body Struggles Through IFS with Vanessa Kredler

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Can hearing loss increase your risk of dementia? Can you have a normal hearing test but still struggle to understand conversations? These are some of the biggest questions in hearing science—and the answers may change the way you think about brain health, cognitive decline, and longevity.In this episode of the Crackin' Backs Podcast, internationally recognized hearing researcher Dr. Nicholas Reed explains the powerful connection between hearing loss, brain health, cognitive load, memory, aging, and dementia prevention. Learn why traditional hearing tests may miss important problems, how the brain—not just the ears—processes sound, and why hearing could become one of the most important vital signs for healthy aging.You'll discover:Why people struggle to hear in noisy restaurants despite a normal hearing testThe connection between hearing loss, cognitive decline, and dementiaHow hearing affects memory, attention, and brain functionWhether concussions, whiplash, and head injuries can impact hearingCan the brain be trained to hear better?What everyone should know to protect hearing and brain health for lifeIf you're interested in longevity, Alzheimer's prevention, cognitive health, healthy aging, hearing loss, brain optimization, auditory processing, concussion recovery, or evidence-based health, this conversation is for you.Subscribe to Crackin' Backs for weekly documentary-style conversations with the world's leading experts in longevity, performance, neuroscience, and human health.We are two sports chiropractors, seeking knowledge from some of the best resources in the world of health. From our perspective, health is more than just “Crackin Backs” but a deep dive into physical, mental, and nutritional well-being philosophies. Join us as we talk to some of the greatest minds and discover some of the most incredible gems you can use to maintain a higher level of health. Crackin Backs Podcast

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What happens when you know something is wrong, but no one believes you?In this heartfelt episode of Love Conquers Alz, Susie Singer Carter and Don Priess welcome Nancy Treaster, co-founder of  The Caregiver's Journey, to discuss her husband, Kim Treaster's battle with Frontotemporal Dementia (FTD) and the long road to an accurate diagnosis. Nancy is a certified caregiving consultant and co-founder of The Caregiver's Journey, Nancy shares the subtle behavioral changes that first raised concerns, the frustration of being told it was "just anxiety," and why caregivers must trust their instincts when something doesn't feel right. Together, they explore the differences between Alzheimer's disease and Frontotemporal Dementia, the challenges of language loss (primary progressive aphasia), and the importance of advocating for a loved one when the medical system falls short.The conversation also dives into some of the most emotional aspects of caregiving:• Recognizing the early signs of FTD• Why spouses and family members often notice symptoms first• How to advocate for an accurate diagnosis• Protecting your loved one's dignity throughout the disease• Navigating aggression, incontinence, and difficult behaviors with compassion• What it means to become a "pragmatic caregiver" and find peace in the present moment• Why love can endure, even when memories fadeNancy's wisdom reminds us that while dementia changes relationships, it doesn't erase love.If you're caring for or walking beside someone living with FTD or any dementia diagnosis, this conversation will leave you feeling seen, supported, and inspired.* The short film mentioned in the podcast:  Love At First Sight starring British actors Sir John Hurt and Phyllida Law Send us Fan MailIf someone you love experienced neglect in a nursing home…Then you know how desperately the system needs to change.  History has shown us that It takes people power to change anything worthwhile. That's why we we're launching something that's never been done before. On September 27, communities across the country are coming together for the first-ever National Long-Term Care Reform Day.This is a peaceful national walk for dignity, accountability, and change in long-term care.We'rSupport the showNo Country For Old People; a Nursing Home Exposé is STREAMING NOW on Amazon Prime (https://www.amazon.com/gp/video/detail/B0F7D1RR5X/ref=atv_dp_share_cu_r) Visit the No Country For Old People Website for more information.Please watch. Review. Share.Be a ROAR-ior!! JOIN THE R.O.A.R. MOVEMENT (Respect, Oversight, Advocacy, Reform) for quality long term care! Visit the ROAR 4 LTC Website for more information and consider participating in the inaugural National National Long-Term Care Day, Sunday, September 27th The 1st ever ROAR 2026 National Walk for Long-Term Care Reform! Found out more here: https://www.roar4ltc.org/roar-2026-walkFollow us on Twitter, FB, IG, & TiK Tok

Tatiana Rojas was a former gym teacher and long-time social worker in New York when she decided to tackle her first marathon at nearly 50 years old. What started as a decades-long dream watched on television blossomed into a mission-driven journey across the World Marathon Majors. Growing up watching the New York City Marathon, Tatiana always vowed that one day she would cross that finish line herself. After immigrating to the United States and waiting 20 years—unaware that entry required a lottery draw—a casual conversation with a coworker finally set her journey in motion. She applied, won a spot, and finished her debut marathon in 7 hours, 37 minutes, and 11 seconds. That first race was a complete trial by fire. Naive about training, course logistics, and post-race recovery, she spent a full week recovering in bed and declared she would never run another. The pull of the distance proved too strong to walk away from. Tatiana returned to the marathon with structured coaching and a deeper purpose, dedicating her miles to raising funds for Alzheimer's and dementia research. From there, she committed to the NYRR 9+1 program, kept her momentum through virtual events during the pandemic, and systematically began checking off world majors. Throughout her journey, raising funds for causes bigger than herself became a central pillar. She has raised over $10,000 across various campaigns supporting children and families with disabilities, Catholic Charities, heart disease research, and animal welfare organizations. Just four years after stepping up her structured training, Tatiana completed the Boston Marathon—running alongside her friend Maria Fernanda—to officially earn her Six Star Finisher Medal. Her major marathon achievements include: New York City Marathon: Her foundational race, run multiple times including her debut and post-pandemic returns. Chicago Marathon: Site of her official marathon personal record of 5:48. Berlin & London Marathons: Completed as part of her international major series push. Tokyo Marathon: Completed while raising funds for animal rescue organizations. Boston Marathon: The final piece to lock in her Six Star Finisher Medal. Paris Marathon: Completed during the Olympic year, running the mass participation night marathon. Now turning 66, Tatiana views every mile as an investment in her health, longevity, and vitality. Rejecting the idea that age should dictate limits, she credits running with keeping her prescription-free and deeply connected to a global running community. Her race-day mental strategy relies on positive self-talk—literally speaking to her legs between miles 18 and 23 to overcome fatigue and finish strong. With upcoming plans to run the Sydney Marathon and target the new World Marathon Majors expansion stars, Tatiana continues to prove that passion and persistence have no expiration date. Our website: https://www.marathonjournal.comInstagram: https://www.instagram.com/runningpodcastYouTube: https://youtube.com/@marathonjournalFollow us on Strava: https://www.strava.com/athletes/30798607

When Caring for Someone With Dementia Means Learning to Care for Yourself TooAlzheimer's disease and other forms of dementia don't just change the life of the person diagnosed—they can transform the lives of everyone who loves and cares for them.In this powerful episode of The Raw Vibe Podcast, Chuck Tuck sits down with James Sylvan Russell and Carol Hosler for an honest and deeply personal conversation about Alzheimer's, dementia caregiving, family, love, loss, resilience, and the importance of supporting the caregiver as much as the person receiving care.James shares his firsthand experience caring for a loved one with dementia and the lessons he learned about the emotional and practical challenges caregivers face. We explore the loneliness, stress, exhaustion, and uncertainty that can accompany dementia caregiving—and why caregivers need their own support system to avoid becoming isolated and overwhelmed.A central part of our conversation is the four pillars of a Love Team: Care, Prepare, Share, and Repair.These four principles offer a practical framework for building a community around someone living with Alzheimer's or another form of dementia while also giving the primary caregiver the support they desperately need.CARE — Commit to being present and providing meaningful support.PREPARE — Learn how to connect with someone living with dementia through memories, music, stories, photographs, familiar objects, and meaningful experiences.SHARE — Communicate with other members of the support team, share experiences, celebrate successes, and learn from challenges.REPAIR — Recognize when something isn't working, adapt, try new approaches, and continually improve the caregiving experience.Carol and Jim also share their deeply personal journey of love, caregiving, loss, and finding meaning through one of life's most difficult chapters.This conversation is about much more than Alzheimer's or dementia. It's about human connection, compassion, community, and the understanding that no caregiver should have to do this alone.Whether you are caring for a parent, spouse, partner, family member, or friend living with dementia—or know someone who is—this episode offers hope, perspective, and practical ideas for creating a stronger support network.

When Jessica Guthrie's mom, Constance, was diagnosed with Alzheimer's disease at just 65 years old, Jessica was only 26. Nearly 12 years later, Jessica has experienced the caregiving journey through changing routines, wandering, researching memory care, hiring in-home caregivers, moving back into her childhood home, hospice and now providing around-the-clock care for her mom in the advanced stages of Alzheimer's. In this deeply personal conversation, Jessica returns to Desperately Seeking Senior Living to share what that journey has really looked like - including the things she wishes she had known earlier. ✓ Why Jessica ultimately left her life in Texas and moved home to Virginia ✓ How routines and a familiar environment helped her mom ✓ Why dementia caregiving requires trying, adjusting and trying again ✓ Her experience researching memory care and in-home care ✓ What families should know when hiring caregivers ✓ Why the energy caregivers bring into the room matters ✓ The reality of caring for someone with advanced Alzheimer's ✓ How Jessica thinks about hospice and the end of life ✓ The unexpected people who became part of her caregiving support system ✓ Why an Alzheimer's diagnosis doesn't mean joy, connection and making memories have to end Jessica also shares a powerful reminder for family and professional caregivers: you are the thermostat. The energy you bring into the room can help set the temperature for the person receiving care. And perhaps her most important message? A diagnosis is not the end. It can be an invitation to get closer, be present, continue making memories and keep finding moments of joy with the person you love. @jessica_c_guthrie Subscribe for practical dementia and senior care tips that help families go from desperate to doable.

Send us Fan MailAre you familiar with the term "ambiguous loss"? Just about all of us go through it at some point in our lives, but it's something Barb couldn't quite put a name to until her old friend and recurring guest Denise Torgerson described it to her. Ambiguous loss can come about in countless different ways, but most commonly, we feel it following the onset of Alzheimer's/dementia in a close family member or upon becoming estranged from family or friends. That ache we feel when someone leaves our lives without proper closure, or when a person has declined so much that we start to grieve the version of them we once knew? That's ambiguous loss. It happens to everyone, it's very hard to deal with, and surprisingly few people are actually talking about it.Thankfully, Denise is here to continue the conversation with Barb and help us all get a better understanding of what exactly causes those feelings of ambiguity, as well as what we can do to heal from it. They go over different types of loss, different coping strategies, some important realizations, and most importantly, that these feelings should not be ignored. As Denise says, if you are experiencing ambiguous loss right now, it is definitely worthy of your attention.Find us on Instagram @convoswithboomerspod.If you like our show, make sure you follow us on your favourite Podcast player. Feel free to rate and review our show and tell us what you'd like to hear, and what other topics you'd like Barb to explore!

AI can write the essay, calculate the answer, summarize the book, and solve the problem before you have really had to think. Jim Kwik's concern is not just cognitive offloading. It's cognitive surrender. After 34 years teaching people how to learn, remember, read, and focus, he believes the real risk of AI is that technology starts doing so much of the mental work that we stop building the abilities we need most. In this episode, Louisa sits down with Jim to unpack what happens when we outsource memory, judgment, creativity, and critical thinking. He explains why learning requires effort, why the brain follows a "use it or lose it" principle, and what research comparing students using ChatGPT, search engines, or no assistance suggests about cognitive engagement and recall. They also explore cognitive reserve, metacognition, attention, reading, sleep, and why doing difficult things may be one of the best ways to protect the brain. Jim also shares the brain injury that shaped his life, the period when severe sleep apnea left him sleeping around 90 minutes a night, and the habits he now uses to protect his cognition. You'll hear why he says "mind before media," why reading is exercise for the brain, and how to use AI as augmented intelligence without giving up your own. The goal isn't to reject technology. It's to stay the pilot of your brain, not the passenger.

Juliette isn't the first Francis we've had on our show, although she is married to one of them. We'll let you guess which. What we won't let you guess is how to help fight Alzheimer's, because that shouldn't be left to chance. Juliette is the new executive director of the Alzheimer's Association of Minnesota, North Dakota, and Montana. She's also, like Dan, raising funds for the Alzheimer's Association. Dan is biking, Juliette is walking. Now all we need is the sea and the sky covered and Alzheimer's won't have a chance. I think Sun Tzu wrote about that.To donate to Juliette's cause, visit https://act.alz.org/site/TR?team_id=1088692&pg=team&fr_id=19720.

SpaceTime Series 29 Episode 95 Spectacular vortices discovered on the Sun's surface Astronomers have for the first time observed swirling whirlpool like vortices deep in the Sun's photosphere – its visible surface. The event horizon of merging black holes seen for the first time Astronomers have for the first time picked up gravitational waves from the event horizon during the actual merger of two black holes. Starship recovery efforts underway off Western Australia SpaceX are towing their Test 13 Starship prototype back to shore after it survived its Indian Ocean soft splash down off the Western Australian coast. The Science Report Scientists develop a new blood test to help test for signs of Alzheimer's. E-scooter riders found to be 3.5 times more likely than motorcyclists to get traumatic brain injuries. Reshaping sciences understanding of mammal evolution during the age of dinosaurs. A new study shows how wireless charging for drones could be achieved using lasers. Skeptics guide to claims Artemis II was a hoax. This Week's Guests Professor Robert Ward from the Australian National University   Our regular guests: Alex Zaharov-Reutt from techadvice.life Tim Mendham from Australian Skeptics  

Episode 26-32 Insulin Resistance- The "Silent Killer" You Probably Have, But Don't Know It Do you have Insulin Resistance? That's a question you should know the answer to. Why? Because Insulin Resistance is linked to nearly every major chronic disease. Diseases such as High Blood Pressure, Diabetes, Alzheimer's, Stroke, Parkinson's, Fibromyalgia, Multiple Sclerosis, Obesity, Heart Disease, and Autoimmune Disorders.  Insulin Resistance is also something very few doctors talk about. Why? I honestly don't know. But what I DO know is this: YOU need to know about Insulin Resistance… AND you need to know how to find out whether or not you have it. This is especially true if you are over the age of 30 as the majority of American adults HAVE Insulin Resistance and don't even know it! On this episode I talk about Insulin Resistance and how to determine if you have it. Give this episode a good listen and, as always, be sure to share it with a friend.  Thanks!  ———————- Want to learn more? Continue the conversation regarding this episode, and all future episodes, by signing up for our daily emails. Simply visit: GetHealthyAlabama.com  Once there, download the "Symptom Survey" and you will automatically added to our email list. ———————- Also, if you haven't already, we'd appreciate it if you'd subscribe to the podcast, leave a comment and give us a rating. (Thanks!!!)  

           * This podcast is for informational and educational purposes only. It is not intended to diagnose or treat any disease. Please consult with your health care provider before making any health-related changes.

Send us Fan MailMitochondrial peptides act as stress signals that regulate metabolism, muscle mass, and neurodegeneration.TOPICS DISCUSSED:Mitochondria as Communication Hubs: Beyond ATP production, mitochondria encode peptides that regulate cell death, immunity, and inter-organ communication.Humanin Discovery: Identified independently by three labs; neuroprotective, longevity-linked, and capable of neutralizing APOE4 effects via a rare Jewish variant.Ethnic Genetic Variants: Ancestry-specific mutations in MOTS-c, MENTSH, and SHMOOSE influence diabetes, obesity, sarcopenia, and Alzheimer's risk.MOTS-c & Muscle Preservation: Exercise-induced peptide prevents atrophy and may offset muscle loss seen with GLP-1 drugs.Peptide Classes: Fragments of larger proteins, endogenous microproteins from small genes, and emerging AI-designed artificial peptides.Diet Modulation: Mediterranean diet adherence raises circulating levels of the peptides humanin and SHMOOSE.Clinical Reality Check: Early MOTS-c trials showed metabolic benefits; unregulated products often contain inaccurate doses.ABOUT THE GUEST: Pinchas Cohen, MD is Dean of the USC Leonard Davis School of Gerontology and a leading researcher on mitochondrial peptides in aging, metabolism, and neurodegeneration.RELATED CONTENT:Article | Metabolic Stress & the Peptide MOTS-c: How Much is Too Much?Podcast | MOTS-c & Mitochondrial Peptides in Health & Aging | David LeeSupport the showSupport my work:Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.For all the ways you can support my efforts.

We're digging into a reframe that can change the way a lot of us think about depression, anxiety, stress, and mental health treatment. The reframe has to do with the very common belief that there's one logical fix waiting to be found and that once found, we'd feel better and all will be fixed. The truth is that the way through overthinking, stress, and even anxiety and depression looks a little different for every person. Another thing we'll work to reframe in this episode is the culturally reinforced illusion that feeling better has to be just as heavy as feeling bad. The main strategy we'll lean on to go beyond these common obstacles is right in line with our Elements of Fun and Recreation... it's play! Truly, play is powerful.  Note: This is an encore episode, originally aired during Joy Lab's Element of Fun. It's replaying here during the month of Re-Creation because it grounds the science of play in some of the best research available — and because if you haven't heard it, now is exactly the right time. About: The Joy Lab Podcast is an Ambie-nominated podcast that blends science and soul to help you cope better with stress, anxiety, and depression. It's hosted by integrative psychiatrist Dr. Henry Emmons and holistic mental health researcher Dr. Aimee Prasek.   The podcast is best paired with the Joy Lab App.   Bonus: spread some joy and keep this podcast ad-free by donating (Joy Lab is powered by the nonprofit Pathways North and your donations are tax-deductible).   Full transcript here   Sources and Notes:  Joy Lab Experiments: Take the next leap in your wellbeing journey with step-by-step practices to help you build and maintain the elements of joy in your life. Joy Lab Episode #5 referenced: Let Go of Shoulds, Let In Fun More about Karl Popper (Also see: "Of Clouds and Clocks: An approach to the problem of rationality and freedom of man.") Maurice Sendak: https://www.sendakfoundation.org     FAQ Q: I know I should do something fun but I just can't make myself — what's actually going on? A: This episode names some main obstacles clearly: anhedonia (the inability to feel pleasure that is a red flag for depression), the belief that there's one logical fix waiting, metacognition blocking you from being present during play, and the fear of losing or not doing it right — and offers specific practical strategies for each one.   Q: Does healing from depression really have to be so heavy and hard, or can fun actually be part of it? A: This episode makes the direct case that play is a legitimate healing tool, not a distraction from "real" work. There's good scientific evidence to support play as a valuable adjunctive tool to treat depression.     Key moments: [00:00] Aimee introduces the encore: this episode gets practical about what blocks fun and how to get past it [02:30] First obstacle: anhedonia — the inability to feel pleasure, one of the clearest red flags for depression [03:00] The inertia problem: when you know you'd feel better if you played but can't get yourself to start [04:00] Henry: no shame in needing something to get over the hump — medication or natural therapy as a bridge, not a failure [05:00] "Fake it till you make it" — not denial, just good practice; changing what you do can move your mood [06:30] Second obstacle: waiting for the one logical solution — the single cause bias that makes us believe there's one fix [07:30] Karl Popper's clocks and clouds: clocks are tight, ordered, reducible; clouds are irregular and unpredictable [08:00] Mental health is a cloud — but we keep trying to treat it like a clock (one diagnosis, one medication, one solution) [09:00] Henry: the human brain is extraordinarily complex — one thing influences another influences another; the clock model just doesn't hold [10:30] The way out of anxiety and depression is a little different for everyone — just like fun looks different for everyone; C.S. Lewis: "Have fun, even if it's not the same kind of fun everyone else is having." [12:00] The clouds complexity is actually empowering: opening to more than one solution puts the power back in our hands [13:00] Third obstacle: metacognition — thinking about thinking — a useful skill that blocks fun when overused [14:00] Henry: metacognition from a Buddhism and neuroscience conference — observing yourself as a thinker, one of the main benefits of mindfulness [16:00] Aimee: metacognition can block you from starting to play AND take you out of it once you're there [18:00] Ted Lasso and Danny Rojas getting the yips — a vivid example of how overthinking destroys play even for the most joyful players [21:00] Preparing for fun: anticipation is part of the enjoyment — let yourself get excited in advance [21:30] Simple preparation: take a break from the phone or computer for an hour or two before a fun event [24:00] Strategy: pick a playful activity you did as a kid and do it for two or three minutes today; Don't overthink it — the activity is already part of you; just uncover it [25:00] Carl Jung: "The small child is still around and possesses a creative life which I lack, but how can I make my way to it?" — engaging in childhood play was Jung's own answer [27:00] Grounding practices and movement: research supports releasing fear, tension, and feeling more connected through physical grounding [28:30] Playful movement: fuller breaths, better digestion, reduced muscle tension, reduced fatigue — worth every minute [29:30] Henry: you can be less tired by expending more energy — paradoxical but true, and even one minute of movement can shift how you feel [30:00] Letting go of the outcome — the hardest obstacle, especially for overachievers and the competitive [32:30] Aimee: when you're not afraid to lose, the world opens up — you can play more, trust more, even love more [33:00] The path to feeling better doesn't have to be as depressing as how you've been feeling — the remedy doesn't have to always be bitter [33:30] Aimee's clubhouse story: caring for her mom with Alzheimer's, a hard week of financial and planning details, too much parenting [35:30] This was different from Netflix or a formal meditation — it was a fun break, and it created an upward spiral [37:00] Maurice Sendak on play: "It is through fantasy that children achieve catharsis. It's the best means they have for taming wild things." [37:30] Adults need this catharsis too — let's take fun more seriously as a tool for healing and for taming our wild things   If you enjoyed this episode, please rate and review us wherever you listen to your favorite podcasts!    Please remember that this content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Please consult your doctor or other qualified health professional before beginning any diet change, supplement, or lifestyle program. Please see our terms for more information. If you or someone you know is struggling or in crisis, help is available. Call the NAMI HelpLine: 1-800-950-6264 available Monday through Friday, 10 a.m. – 10 p.m., ET. OR text "HelpLine" to 62640 or email NAMI at helpline@nami.org. Visit NAMI for more. You can also call or text SAMHSA at 988 or chat 988lifeline.org. Find more mental health resources here.

  In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan welcomes renowned neurologist and bestselling author Dr. David Perlmutter to explore the emerging science behind brain health, neuroinflammation, and cognitive resilience. Drawing from his groundbreaking new book, Brain Defenders, Dr. Perlmutter explains how microglia—the brain's immune cells—play a central role in protecting or damaging the brain depending on our metabolism, lifestyle, and environment. Together they discuss why Alzheimer's and Parkinson's disease begin decades before symptoms appear, why inflammation and insulin resistance are major drivers of neurodegeneration, and what we can do today to protect lifelong brain health. Whether you're concerned about memory loss, dementia prevention, or optimizing cognitive performance, this episode offers science-backed strategies to build a healthier, more resilient brain.

Twenty-five years ago, a single participant enrolled in what would become the Wisconsin Registry for Alzheimer's Prevention (WRAP), now one of the largest and longest-running studies of Alzheimer's risk in the world. To celebrate this milestone, we're joined by Dr. Mark Sager, who co-founded WRAP, along with current multi-principal investigators Dr. Sterling Johnson and Dr. Jessica Caldwell, to discuss how the study has evolved, the discoveries that have reshaped our understanding of Alzheimer's prevention and what the next 25 years may hold for the field.  Guests: Mark Sager, MD, founder, Wisconsin Alzheimer's Institute (WAI), WRAP, Sterling Johnson, PhD, multi-principal investigator, WRAP, associate director, Wisconsin Alzheimer's Disease Research Center, WAI, Jessica Caldwell, multi-principal investigator, WRAP, visiting associate professor, department of neurology, University of Wisconsin-Madison Show Notes This episode was uploaded as an exclusive video episode on the Wisconsin ADRC YouTube page on August 12, 2026. Watch the video interview here. Listen to our episode with Dr. Gina Green-Harris, mentioned at 12:27, on our website. Learn more about WRAP on the WRAP website. Learn about Drs. Sager, Johnson and Caldwell at their profiles on the WAI website. Connect with us Find transcripts and more at our website. Email Dementia Matters: dementiamatters@medicine.wisc.edu Follow us on Facebook, Instagram and Twitter. Subscribe to the Wisconsin Alzheimer's Disease Research Center's e-newsletter. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer's. All donations go toward outreach and production. Learn about Dr. Chin's book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia.

What if some of what you've been told about exercise and aging is incomplete?Maybe you've heard you need to walk more. Lift heavy. Work on your grip strength. Or simply accept that more aches, less strength, and declining mobility are inevitable as you get older.But which of those things actually matter most if your goal is to protect your brain, stay independent, and keep doing the things you love 10, 20, or even 30 years from now?In this episode, I'm talking with Dr. Cody Sipe, co-founder of the Functional Aging Institute, about what an exercise program for healthy aging really needs to include.And we clear up a few ideas that sound convincing on social media but don't tell the whole story.Like why grip strength may not mean what you think it means.Why strength training alone isn't enough.And why one of the most valuable types of training for healthy aging also happens to be one of the easiest to overlook.Then we get practical.What if you have an hour to exercise? What if you only have 30 minutes? Or 15?And do those five-minute bursts of movement throughout your day actually count?If you want to exercise in a way that supports not just a longer life, but a stronger body, healthier brain, and greater independence, this conversation will help you rethink what deserves your time.What to Listen For[04:21]  Does getting older really mean everything goes downhill?[07:46]  Why Cody wants us to replace “retirement” with “refirement”[09:12]  What 4 elements belong in an ideal exercise program after 50?[11:17]  The question to ask before choosing your exercises[14:53]  When “just start lifting weights” may be the wrong advice[20:35]  Cardio or strength training: Which is more important for longevity?[22:45]  The surprisingly low-effort form of exercise with a big payoff[23:50]  The problem with all that advice about grip strength and longevity[25:33]  The “Miracle-Gro for your brain” that exercise helps stimulate[27:30]  What standing on one leg has to do with your brain[28:39]  The exercise connection to insulin resistance and brain health[53:19]  Only have 30 minutes? Here's what matters most[54:55]  Can 15 minutes really be enough?[55:21]  Do five-minute bouts of exercise count?One Big Idea to Take With YouI keep coming back to something Cody said early in our conversation:The purpose of exercise isn't simply to get better at exercise.It's to support the life you want to be able to live, so If you've been telling yourself you don't have enough time to exercise, I especially want you to listen through the end of this conversation.Thirty minutes counts.Fifteen minutes counts.And those little bursts of movement you fit between everything else in your life? Those may count more than you realize.Listen to the full episode of Happy and Healthy with Amy Lang, then follow the show on Apple Podcasts or Spotify so you don't miss future conversations about the habits that can help protect your health—and your brain—as you age.And send this episode to the friend who keeps telling you, “Getting older just means everything gets worse.”RESOURCES:Download the FREE Excerpt of Thoughts Are Habits TooPurchase Thoughts Are Habits TooBook a FREE Discovery Call with AmyDownload After Mom's Alzheimer's Diagnosis: The First 8 Things to Know and learn how to support her with more calm, clarity, and confidence.Download the RESTORED Protocol: Eight Essential Protective Factors to Build an Alzheimer's-Resistant BrainSchedule your Breakthrough Roadmap session with AmyFollow Amy on Instagram @amylangcoaching  and on Facebook @amylangcoachingSubscribe to Amy's YouTube channel @happyandhealthywithamy

Obstructive sleep apnea affects approximately one in four adults and is especially common among patients with neurologic disorders, including stroke, Parkinson disease, dementia, epilepsy, and neuromuscular conditions. In this episode, Dr. Stephanie Stahl discusses why neurologists should routinely screen for OSA, highlights key symptoms and risk factors, reviews important considerations when interpreting sleep studies, and outlines current treatment options beyond CPAP. Learn how recognizing and treating sleep apnea can improve quality of life, optimize management of neurologic disease, and reduce long-term health risks. In this episode, Aaron L. Berkowitz, MD, PhD, FAAN, speaks with Stephanie M. Stahl, MD, FAASM, author of the article "Obstructive Sleep Apnea" in the Continuum® August 2026 Sleep Neurology issue. Dr. Berkowitz is a Continuum® Audio interviewer and a professor of neurology in the Department of Neurology at the University of California, San Francisco, in San Francisco, California. Dr. Stahl is an Associate Professor of Clinical Medicine and Sleep Medicine Fellowship Program Director at Indiana University School of Medicine in Indianapolis, Indiana, where she also serves as Sleep Laboratory Medical Director in the Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine. Additional Resources Read the article: Obstructive Sleep Apnea Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @AaronLBerkowitz  Full episode transcript available here Dr Berkowitz: Obstructive sleep apnea is very common. It can cause or contribute to common neurologic symptoms, such as headache and impaired cognition, and it's a risk factor for stroke. And yet, if you're like me, you may not know too much more about sleep apnea than that. Today, I have the pleasure of talking to sleep expert Dr. Stephanie Stahl to learn what every neurologist should know about OSA.  Dr Jones:  This is Dr. Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast.  Dr Berkowitz: This is Dr. Aaron Berkowitz. Today I'm interviewing Dr. Stephanie Stahl about her article on obstructive sleep apnea. This article appears in the 2026 Continuum issue on Neurology of Sleep. Welcome to the podcast, Dr. Stahl, and could you please introduce yourself to our audience?  Dr Stahl: Yeah. Thank you for having me. I'm a sleep medicine physician and neurologist and medical director of the Indianapolis Sleep Lab at Indiana University Health. I serve as the director of the Sleep Medicine Fellowship program. I'm faculty advisor for our very first student interest group in sleep medicine at Indiana University School of Medicine. I'm also actively involved in some national leadership roles, including the incoming chair of the American Academy of Sleep Medicine's Education Committee and co-chair of the Academy's Inter-Scorer Reliability Gold Standard Panel. So, I really appreciate this opportunity. I look forward to our discussion.  Dr Berkowitz: Me too, and we appreciate the opportunity too to get to talk to you. You have so much expertise in this area, and I certainly encourage our listeners to look at your article, which is very comprehensive and up to date, and I learned a ton from it. I didn't get much exposure to sleep neurology as a trainee, and I've always worked in academic centers where we have a sleep group and we can refer patients there. So, I have to admit, sleep may probably be the area of neurology I know the least about, and felt like I was learning something new from pretty much every line of your article, and I know our readers will too. So, your article has a lot of excellent detail for our readers on the diagnosis and treatment of this very common condition. But I'd like to keep our interview relatively high level today and focus on the essentials for the practicing general neurologist. So, to start, can you just give us a sense of what obstructive sleep apnea is, and what every neurologist should know about it?  Dr Stahl: Yeah. So obstructive sleep apnea is characterized by either partial or full obstructions in the upper airway. That may sound pretty simple, but this leads to a whole bunch of issues. It leads to oxygen desaturations, arousals from sleep, leading to sleep fragmentation. This can then lead to sympathetic nervous system activation, cerebral hypoperfusion, leading to a whole bunch of symptoms or neurologic conditions.  Dr Berkowitz: Great. And you mentioned this in your article, but just to emphasize, how common is obstructive sleep apnea in the general population?  Dr Stahl: Yeah. So, about a quarter of the general population have obstructive sleep apnea. Much more common in many neurologic conditions.  Dr Berkowitz: Yeah, so very common disorder. We are seeing patients with it quite frequently, whether that's the reason they are seeing us in neurology or not. And this leads to my next question, which is what neurologic symptoms or presenting concerns of a patient should make us think about OSA and the differential diagnosis, and what factors based on the history or the exam or the context would make you suspicious for OSA as the cause of a neurologic symptom? In other words, the patient's presenting with classic symptoms of OSA, and that's why they're seeing a neurologist or seeing a primary care doctor, but is coming for evaluation of, say, headache or other symptoms. And what symptoms would make you think of wanting to consider OSA, and then what aspects of the history or otherwise would make you want to evaluate the patient for OSA?  Dr Stahl: I think a really important takeaway is for neurologists to know that obstructive sleep apnea is very common in neurologic conditions and has that potential to worsen a lot of these conditions or their associated symptoms. And so, it should be on our radar. There are certainly some basic questions and signs and symptoms that we can ask patients about or, or take a look at on exam. And so particular symptoms include snoring. Anybody that snores loudly or frequently, that's a strong risk factor for obstructive sleep apnea. If someone's seeing them stop breathing in their sleep, if they are waking up a lot throughout the night. There are some other symptoms that we may not necessarily attribute upfront to obstructive sleep apnea, such as nocturia, nocturnal reflux, night sweats. There are some daytime symptoms, of course, too, like unrefreshing sleep, daytime sleepiness, morning headaches, an important one in neurology. And then we take a look at the patient's exam. And so, some things that neurologists might want to be thinking about are people with obesity are certainly at a risk for obstructive sleep apnea. But it's also very important to know that someone does not need to have obesity in order to have obstructive sleep apnea. We look at neck size, other morphologic characteristics, such as how much that we can see in the back of their mouth. Can we see their uvula? Does their tongue size appear large in their mouth? And then some other risk factors too, such as male gender, older age, family history, post-menopausal state in women. All that being said, though, sometimes in neurologic conditions, we don't have all of those symptoms or risk factors to be thinking about. And so, in certain neurologic conditions such as stroke where obstructive sleep apnea is very common and has the potential to increase the risk of another stroke, we may need to be thinking about testing these patients even with minimal symptoms or other risk factors.  Dr Berkowitz: That's very helpful. So, you mentioned their headache might be the presenting symptom, right, to a neurologist, and we should certainly be thinking about obstructive sleep apnea as a potential diagnosis, even the cause of the patient's headache, particularly you said patients with morning headache. I often try to think about in patients presenting with, for memory loss, or other cognitive concerns, and that may be due more to inattention from poor sleep, so asking about sleep and symptoms of sleep apnea in those contexts. Are there any other presenting neurologic symptoms not particularly related to sleep? I'm thinking of headache, memory loss, other symptoms that would make you think, "Oh, I should actually screen this patient for sleep apnea also."  Dr Stahl: Yeah, other symptoms to think about in pediatrics, hyperactivity, people that have impaired vigilance, as you alluded to, that poor attention. Sometimes people get misdiagnosed with ADHD, and it's actually just a manifestation of obstructive sleep apnea.  Dr Berkowitz: You alluded to this, Dr. Stahl, that stroke, for example, patients are at higher risk of developing sleep apnea as a result of stroke, and it's also a risk factor for stroke. What other neurologic conditions, primary neurologic diseases, put patients at a higher risk of OSA? And again, similar to the last question I asked you, what are some clues that we should evaluate for? We might be following a patient for their post-stroke care over time and not necessarily thinking about diagnosing a separate condition in them since we're following them for their stroke or their degenerative disease. What are the conditions that put patients at a higher risk of OSA as a result of the condition, and then when would you think about screening them for it?  Dr Stahl: Some particular neurologic conditions where obstructive sleep apnea are very common, in addition to stroke and, and TIA, include Parkinson disease. It can worsen a lot of the motor, cognitive symptoms, sleep disruption that we can see in Parkinson disease. Very common in all causes of dementia, but in particular Alzheimer disease and Lewy body dementia. Very common in neuromuscular conditions. We should definitely have obstructive sleep apnea and all forms of sleep-disordered breathing high on our radar. In conditions like myotonic dystrophy. Charcot-Marie-Tooth is another one where obstructive sleep apnea is very common. Myasthenia gravis, it can worsen the symptoms of that. In particular, a pearl is if somebody has morning weakness in myasthenia gravis, obstructive sleep apnea should be high on your radar. And also, as you mentioned, any forms of headaches. There are some other things too. If somebody has poor seizure control, especially nocturnal seizures, you might have obstructive sleep apnea on your radar as well.  Dr Berkowitz: So, I think you've covered essentially every category of neurologic disease, right? We have cerebrovascular, movement, neurodegenerative, neuromuscular, epilepsy, all conditions where either the disorder itself, such as stroke or the, correct me if I'm wrong, the neurodegenerative disease puts the patient at risk. Or the patient may be at risk for exacerbations of their disease, as you mentioned in myasthenia. I love that pearl. Not fatiguable at the end of the day, but if the patient with myasthenia is telling you they're feeling weaker at the beginning of the day, then think about obstructive sleep apnea and that obstructive sleep apnea worsening control of epilepsy due to poor sleep. So really a lot of bidirectional interactions with this common condition. Okay, so if we're concerned about obstructive sleep apnea, again, myself, a general neurologist speaking perhaps on behalf of other general neurologists, we see a patient with headache or reporting memory loss that we find to be impaired attention, or we see exacerbation of their underlying primary neurologic disease. As you mentioned, we think, "Oh, I've listened to this podcast. I've read Dr. Stahl's article. I should probably be thinking about OSA in this patient, and I should order a sleep study." Now, I admit when I get the sleep study back, I scroll to the bottom, I see they do have obstructive sleep apnea, I'm going to send them over to a sleep specialist. But for the general neurologist, what are some high-yield pearls and some pitfalls to be aware of when we get sleep studies for obstructive sleep apnea, and we are looking at the results? Dr Stahl: The first thing is to understand that there are two main types of sleep studies: in-lab polysomnography and home sleep apnea test. In-lab studies are typically what we consider the more accurate type of study. Main reason for that is that we have EEG, so we can see if someone is awake versus asleep. Most home sleep apnea tests do not utilize EEG, and so when we're looking at respiratory events, apneas or hypopneas, we're looking at over the total recording time rather than the total sleep time. So, we know we're going to capture some time where a person is awake, where we don't have sleep apnea events, and that can be a big amount of time in people with insomnia, poor sleep efficiency. And as a result of that, it can lead to an underestimation of the apnea-hypopnea index. That's really important for people to understand that that means we can end up with a false negative home sleep apnea test, or it can put them in a category of lower severity than what they actually have. And so, if you get a home sleep study report back that's negative for sleep apnea and you remain concerned, you need to go on to do an in-lab study, where about twenty to fifty percent of people will go on to have a positive in-lab study. You can also get false positives with home sleep apnea tests too, and so ideally, we should only be doing home sleep apnea tests in people that are at high risk of having obstructive sleep apnea to decrease our chance of false positive study. When we get that sleep study report, what's important to take a look at? So the main number that we look at currently is the apnea-hypopnea index. The number of apneas, which are full obstructions in that upper airway, or hypopneas, partial obstructions in the upper airway where either there's an oxygen desaturation or an arousal associated with that. Less than five is considered to be normal. Anything five or more gives them a diagnosis of obstructive sleep apnea, and then we stratify them based on the AHI. But it's important to take a look at more than just the apnea-hypopnea index. And while my eyes too on various reports like echocardiograms want to jump to the impression, it is important to take a look at that full report, see what their oxygen levels averaged and what they dipped down to. The arousal index, which is how many times a patient may have woken up briefly throughout the night. Take a look at the histogram, usually an image at the bottom of their report that shows what sleep fragmentation may have been like so that you can take that all in and make that decision. How important are these study findings, and is this a person that would benefit from treatment?  Dr Berkowitz: That's a fantastic overview of sleep studies and some of the highlights to look out for, even if we won't be understanding every detail as you would to know most importantly the caveats about home sleep testing having a fairly high percentage of false negative and false positive results. So being wary if our suspicion is high, and that test is normal or inconclusive to get an in-lab sleep study. And if our suspicion is low or maybe we haven't ordered the test and the patient has had it done elsewhere, and the history doesn't really match up to know that there are false positives on the home studies as well, and again, an in-lab study to settle the diagnosis. Is that right?  Dr Stahl: Yes.  Dr Berkowitz: Okay. Now, for most neurologists, probably if we diagnose OSA, we will be referring the patient to a sleep specialist like yourself for treatment. I think we're all familiar with CPAP and patients being on CPAP. Your article mentions a number of treatment modalities I admit I have not heard of before or maybe heard of in passing, acknowledging most general neurologists are not going to be prescribing or knowing with the nuance that you do as an expert how to decide which treatment a patient would most benefit from or most qualify for. So, can you just give us a broad overview, again, for the general neurologist acknowledging we might see a patient whose past medical history says OSA being treated with fill in the blank. What are the different treatment modalities, and how do you think, just so we can learn from you in broad brush strokes, about particular treatments for particular patients?  Dr Stahl: As you mentioned, most people are familiar with positive airway pressure or PAP therapy, and that does remain our most efficacious treatment. The way I explain it to patients is why PAP therapy is the most effective treatment is it's the only treatment that can take all of the tissues of that upper airway and open them up. Whereas all of our other treatments, we're going to target smaller spaces of that upper airway. So, our first option is if we can get somebody on PAP therapy, we know that that's going to be the best option for the majority. PAP therapy works by basically acting as an air splint to open up the air tissues. Know that masks are not interchangeable. There are masks that cover the nose and go over the nose and mouth and under the nose. Full face masks that cover the nose and mouth, they do typically require higher pressures, also tend to be less comfortable for a lot of patients as well. In addition to different PAP masks, there's different modalities of positive airway pressure therapy too. There are machines that auto-adjust, some that provide fixed pressure, bi-level PAP that provides a higher inspiratory pressure, lower expiratory pressure. Then outside of PAP therapy, there are, as you alluded to, a lot of options and more, continuing to come down the pipeline as well. Mandibular advancement devices or a form of oral appliances has been around for a while. This is device that somebody wears in their mouth. It's preferably customized for their teeth and titratable, meaning that they can make adjustments that pulls their mandible forward in relation to the maxilla in order to pull those tongue tissues further away from the back of the upper airway. That's ideally managed by a qualified sleep dentist or someone that specializes in oral appliance management. Other treatments include surgical options, including hypoglossal nerve stimulation, which is an implanted device that causes the tongue to protrude repetitively throughout their sleep period to hopefully open up the airspace. There's some other surgical options too that open up various places of the upper airway. There's a daytime treatment of obstructive sleep apnea, transoral neuromuscular electrical stimulation that changes the muscle fiber type of the tongue. And then there's some adjunctive treatments that can be helpful too, such as positional therapy, oral facial myofunctional therapy that helps a person breathe better through their nose and may help train the upper airway muscles.  Dr Berkowitz: Great. Well, that's a very helpful overview, and again, I refer our listeners to your article, which talks about all of those modalities in very comprehensive detail. So, Dr. Stahl, as we wrap up our conversation, you have a captive audience of neurologists and neurology trainees here. What would you like to leave us with that every neurologist should know about obstructive sleep apnea?  Dr Stahl: The most important, again, is for neurologists to know that obstructive sleep apnea is so common in your patient population, and it can have a significant negative impact on quality of life and health, including many neurologic conditions. And at the same time, obstructive sleep apnea is very treatable. We have so many options nowadays that we can usually get someone onto adequate treatment. And treatment has that potential to improve several neurologic symptoms and disorders, even at times when you don't think that there's an opportunity to improve symptoms such as say in, headache. So, neurologists really should be screening for signs and symptoms of obstructive sleep apnea, as well as considering testing in high-risk, potentially asymptomatic or minimally symptomatic patients.  Dr Berkowitz: That's a fantastic overview of some of the many pearls that you shared with us today, as well as in your article. So, thank you so much again. Today, I've been interviewing Dr. Stephanie Stahl about her article on obstructive sleep apnea. This article appears in the August 2026 Continuum issue on neurology of sleep. Be sure to check out Continuum Audio episodes from this and other issues. And thank you so much to our listeners for joining today, and thank you again, Dr. Stahl.  Dr Stahl: Thank you again for having me.  Dr Monteith: This is Dr. Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.  

When Caring Becomes Exhausting: Michelle on Caregiver Fatigue, Aging Parents, and Knowing Your Limits In this episode of Conversations with a Chiropractor, Dr. Stephanie Wautier talks with Michelle about something millions of families quietly struggle with: caregiver fatigue. Michelle moved home to help care for her nearly 90-year-old mother after a series of falls and a stroke changed what independent living looked like. What began as a decision rooted in love and safety gradually became a much larger responsibility, affecting Michelle's work, relationships, sleep, stress levels, freedom, and even the way she experiences her relationship with her mother. Stephanie and Michelle talk openly about the role reversal that happens when an adult child becomes a caregiver, the guilt that can come with setting boundaries, the constant worry about falls and safety, and the emotional difficulty of considering assisted living or higher levels of care when a parent desperately wants to remain at home. They also discuss something caregivers do not always give themselves permission to admit: loving someone deeply does not make caregiving easy. Sometimes the greatest challenge is acknowledging that the responsibility has become too heavy to carry alone. Listener Offer This episode of Conversations with a Chiropractor is supported by Lemongrove Oil. Use code DRSTEPHANIE at checkout for 10% off your order. https://www.lemongroveoil.com/ In This Episode Michelle and Stephanie discuss caregiver burnout, moving home to care for an aging parent, personality and relationship changes after a stroke, the mental strain of constantly worrying about safety, losing independence as both caregiver and parent, setting boundaries, respite care, assisted living, guilt, family dynamics, support groups, and recognizing when caregiving has begun to affect your own physical and emotional health. Caregiver Support & Resources Caregiving can feel isolating, but support is available. Alzheimer's Association Support Groups In-person and virtual groups are available for caregivers, including family caregivers and people supporting someone with dementia or cognitive changes. https://www.alz.org/help-support/community/support-groups Alzheimer's Association Michigan Chapter Michigan caregiver groups, online communities, and local support resources: https://www.alz.org/mglc/support Caregiver Action Network Free education, caregiver resources, peer support, and a Caregiver Help Desk: https://www.caregiveraction.org/ These resources can help caregivers connect with people who understand the emotional, physical, and practical realities of caring for someone they love. Conversations with a Chiropractor YouTube: http://www.youtube.com/@ConversationswithaChiro Facebook: https://www.facebook.com/wautierwellness Email: drstephaniewautier@yahoo.com Want to be a guest? Send Stephanie Wautier a message on PodMatch: https://www.podmatch.com/hostdetailpreview/drstephanie Credits Podcast production by Brand|Sound. Start your podcast journey by emailing brandsoundpodcasts@gmail.com. Chapters 00:00 Introduction 00:55 Michelle's Caregiving Reality 03:46 Moving Home to Care for Mom 06:05 How a Stroke Changed Their Relationship 09:34 Recognizing Caregiver Burnout 13:38 When Is More Care Necessary? 16:58 The Rollercoaster of Good Days and Bad Days 20:59 Promises, Guilt, and Medical Necessity 24:32 Putting Your Own Life on Hold 25:58 Boundaries, Vacations, and Respite Care 28:31 What We Would Want for Our Own Children 29:37 Finding Support From People Who Understand 33:36 Admitting That Caregiving Is Hard

This summer, we're revisiting some of Hina and Marla's greatest hits from the first 11 seasons of The LowDOWN. On Season 7, Episode 7 of The LowDOWN: A Down Syndrome Podcast, Dr. Elizabeth Head gives us the lowdown on Down syndrome and Alzheimer's disease.Support the showThe LowDOWN: A Down Syndrome Podcast is produced by the Down Syndrome Resource Foundation. Learn more and support the podcast at DSRF.org.Follow @DSRFCanada on Facebook, Instagram, and Twitter.Leave us a rating and review on Apple Podcasts.

On this episode of Groove with Portia, I sit down with Erica Baccus, author of A Promise Kept, to talk about her love story with her husband, John, his Alzheimer's diagnosis, and their deeply personal decision to travel outside the United States so John could choose how his life ended.We discuss grief, faith, love, Alzheimer's, dying with dignity, and why conversations about our end-of-life wishes need to happen long before a crisis forces our families to make difficult decisions.Connect with Erica Baccus: https://ericabaccus.com/Connect with Portia: https://linktr.ee/portiabkrInterested in being a future guest on Groove with Portia?Send your story or interview pitch to: portiatheproducer@gmail.com

Urinary tract infections (UTIs) are among the most common infections in older adults, but in people living with dementia, they can trigger a sudden and dramatic change in behavior and cognition. A UTI that might cause mild discomfort in a younger, healthier person can instead set off delirium — an acute, fluctuating state of confusion — in someone with Alzheimer's or a related dementia.Dr. Shouri Lahiri is director of the Neurosciences Critical Care Unit and Neurocritical Care Research at Cedars-Sinai and leads the Lahiri Lab. His research focuses on the inflammatory mechanisms that link acute illnesses and infections to delirium and cognitive decline, including the role of immune signaling in brain changes during infection.In this conversation with Being Patient founder Deborah Kan, Lahiri explained why up to one-third of older adults with a UTI can develop delirium, and why that risk is even higher for people with dementia, who have less cognitive reserve to draw on. He discussed why early antibiotic treatment is critical and what caregivers can do — from monitoring hydration and sleep-wake cycles to recognizing subtle signs of urinary discomfort — to help prevent and manage delirium at home. He also shared where his lab's research into anti-inflammatory treatments currently stands.----If you loved this Live Talk, visit our website to find more of our Alzheimer's coverage and subscribe to our newsletter: https://www.beingpatient.com/Follow Being Patient: Twitter: https://twitter.com/Being_Patient_Instagram: https://www.instagram.com/beingpatientvoices/Facebook: https://www.facebook.com/beingpatientalzheimersLinkedIn: https://www.linkedin.com/company/being-patientBeing Patient is an editorially independent journalism outlet for news and reporting about brain health, cognitive science, and neurodegenerative diseases. In our Live Talk series on Facebook, former Wall Street Journal Editor and founder of Being Patient, Deborah Kan, interviews brain health experts and people living with dementia. Check out our latest Live Talks: https://beingpatient.com/live-talks/

Disclaimer: This episode and article are for educational purposes only and are not a substitute for individualized medical advice. Always consult your physician before making changes to your diet, exercise routine, or medications.TL;DR* The CDC's top 10 causes of death account for roughly 74% of all deaths in the US each year, and up to 80% of chronic disease is estimated to be driven by lifestyle factors — diet, movement, sleep, stress, and toxin exposure. * This episode goes cause by cause (heart disease, cancer, COVID/respiratory disease, accidents, stroke, Alzheimer's, diabetes, kidney disease, flu/pneumonia, and suicide) and lays out what the peer-reviewed research says about preventing, slowing, or reversing each one.* Ready to build your own plan? Book a free Metabolic Blueprint Session →The List, and the Number That Should Keep You Up at NightAccording to the CDC, ten conditions account for about 74% of all deaths in the United States every year:* Heart disease* Cancer* COVID-19 / chronic lower respiratory diseases* Accidents (unintentional injuries)* Stroke* Alzheimer's disease* Diabetes* Kidney disease* Influenza and pneumonia* SuicideHere's the part that doesn't get said enough: research estimates that up to 80% of chronic disease is driven by lifestyle factors — diet, movement, sleep, stress, and toxin exposure. Those aren't destinies. They're decisions, and decisions can change.A landmark paper in the Journal of the American Medical Association found that poor diet alone accounts for more deaths in the US than tobacco use. The fork may be more dangerous than the cigarette. And yet, most patients who end up on four to six medications were never once asked what they eat, how they sleep, or whether they move their bodies before those prescriptions were written. That's the difference between a sick care system and a healthcare system.Heart Disease and Stroke: The Most Reversible Disease We KnowHeart disease kills one American every 34 seconds and has held the #1 spot for over a century. But it's also one of the most reversible conditions in medicine.In 1990, Dr. Dean Ornish's landmark Lifestyle Heart Trial showed that intensive lifestyle changes — diet, exercise, stress management, and social support — could reverse coronary artery disease without drugs or surgery. Arterial plaques reduced. Blood flow improved. Chest pain decreased. A 2019 study in the Journal of the American College of Cardiology confirmed it: a plant-predominant diet, regular aerobic exercise, not smoking, and a healthy weight reduced cardiovascular risk by over 80%.What that looks like in practice:* A Mediterranean or whole-food, plant-based diet rich in omega-3s and antioxidants (this isn't the only diet that works — it's the broadest evidence-backed baseline)* Zone 2 cardio (low-intensity aerobic work, three to five times a week — a brisk walk counts)* Managing chronic inflammation, the real driver of arterial plaque formation* Reducing refined sugar and seed oils, which damage the endothelial lining of the arteries* Prioritizing sleep, since poor sleep spikes cortisol and directly harms the heartStroke follows the same playbook: control blood pressure through diet, exercise, and stress reduction. The DASH diet in particular has been shown in multiple studies to lower blood pressure as effectively as medication in many patients.Cancer: 30–50% Preventable, and Possibly More Metabolic Than GeneticTo be clear, this isn't a claim about curing cancer — it's about how much prevention research is available and underused. The World Health Organization estimates that 30–50% of cancers are preventable. The American Institute for Cancer Research has identified lifestyle factors that dramatically reduce risk across multiple cancer types:* Diet. A 2022 meta-analysis in The Lancet linked poor dietary patterns — low fiber, low fruit/vegetable intake, high processed meat — to one in five cancer deaths globally.* Obesity. Excess weight is now the second-leading risk factor for cancer after smoking, because fat tissue is metabolically active and produces hormones like estrogen and inflammatory cytokines that fuel cancer growth.* Exercise. A 2019 study of over 1.4 million people found higher physical activity was associated with lower risk across 13 cancer types, including breast, colon, and endometrial cancer.* Fasting and metabolic health. Emerging research on intermittent fasting and time-restricted eating shows it can lower insulin-like growth factor, a key promoter of cancer cell proliferation.* Toxin reduction. Chronic low-grade exposure to pesticides, plastics (BPA, phthalates), and environmental pollutants has been linked to increased cancer risk. Choosing organic where possible, filtering water and air, and reducing plastic in cookware and storage all matter.There's also a deeper shift happening in how researchers understand cancer itself. It's long been treated primarily as a genetic disease, but the evidence is increasingly pointing toward cancer as a metabolic disease. Dr. Thomas Seyfried at Boston College has done groundbreaking work showing that cancer cells overwhelmingly rely on glucose and glutamine fermentation for energy — which is why a ketogenic or low-glycemic approach may help starve cancer cells while protecting healthy ones. The research is still evolving, but it's compelling.Think of your body like a garden. You can water it, enrich the soil, and pull the weeds — or you can dump sugar and chemicals on it and wonder why nothing grows right. Disease doesn't happen to you. It grows in an environment you create, consciously or not. The good news: you can change that environment starting today.Alzheimer's: “Type 3 Diabetes”Alzheimer's is rising, and it's terrifying to watch someone go through it. But emerging science shows it has a strong lifestyle and metabolic component — researchers now sometimes call it “type 3 diabetes” because of the profound link between insulin resistance and neurodegeneration.Dr. Dale Bredesen's ReCODE Protocol, published in the Journal of Aging, showed that a multimodal lifestyle intervention — diet, exercise, sleep optimization, hormone balancing, and stress reduction — reversed early cognitive decline in the majority of patients treated. In his 2014 case series, 9 of 10 patients with early Alzheimer's or mild cognitive impairment showed measurable improvement, with several returning to work.Key strategies from the research:* Sleep is non-negotiable. The brain's glymphatic (waste clearance) system activates primarily during sleep, flushing out amyloid beta plaque. Poor sleep means plaque buildup.* Exercise. A 2020 study showed aerobic exercise increases BDNF (brain-derived neurotrophic factor) — essentially fertilizer for neurons — and reduces dementia risk by up to 35%.* Mediterranean-MIND diet. Shown to slow cognitive aging by an estimated 7.5 years in adherent individuals.* Blood sugar management. Insulin resistance in the brain disrupts its ability to use glucose for energy, effectively starving neurons.* Social connection. Harvard's 80-year longitudinal study found relationship quality was the single strongest predictor of cognitive health and longevity in old age.Type 2 Diabetes and Kidney Disease: One Disease Driving AnotherOver 37 million Americans have type 2 diabetes, and another 96 million are pre-diabetic. Here's the part that surprises people: type 2 diabetes is reversible in the majority of cases, and this isn't controversial — the science is overwhelming.The 2019 DiRECT trial, published in The Lancet, found that nearly half of type 2 diabetics achieved full remission through an intensive dietary intervention alone, with no medication. Other studies using low-carbohydrate and very-low-calorie diets have replicated these results consistently.Diabetic nephropathy — kidney damage from chronically high blood sugar — is the leading cause of kidney failure in the US. Control the upstream issue (blood sugar and metabolic dysfunction) and you protect the downstream organ.The diabetes reversal framework from the research:* Dramatically reduce refined carbohydrates and added sugars to blunt insulin spikes and reduce fat storage in the liver and pancreas* Practice time-restricted eating or intermittent fasting to improve insulin sensitivity* Add resistance training — muscle is your biggest glucose sink, so more muscle means better blood sugar control* Reduce visceral fat (the fat around and inside your organs), a key driver of insulin resistance and inflammationIf this list feels like a lot, that's fair. But it's not about blame — it's about empowerment. You have more control over your health outcomes than the medical system has typically told you.Respiratory Disease, Flu, and PneumoniaChronic lower respiratory diseases like COPD and emphysema are largely driven by smoking and air quality. Quitting smoking remains the single most impactful intervention here, full stop.For flu and pneumonia risk, immune resilience matters: vitamin D optimization, zinc and elderberry, and gut microbiome health (roughly 70% of your immune system lives in your gut). Even mild sleep deprivation has been shown to quadruple susceptibility to viral infection.Suicide and Mental HealthThis is the cause of death nobody wants to talk about, but it's in the top 10 — and it's the leading cause of death for men under 50, and the second-leading cause of death for people ages 10–34.While this is complex and deeply personal, research points to several lifestyle levers:* Exercise functions as an effective antidepressant, largely through endorphin release* The gut-brain axis matters more than most people realize — over 75% of the body's serotonin is produced in the gut, so gut health directly shapes brain chemistry* Social connection and purpose. Viktor Frankl's Man's Search for Meaning, written while he was in a Nazi concentration camp, captured this: meaning and connection to purpose are essential for survival, and perspective shapes both physiology and outcome* Reducing alcohol, a central nervous system depressant that worsens anxiety and depression despite short-term reliefIf you or someone you love is struggling, crisis hotlines are available 24/7. There's often a reason it's happening, and there's often a way through it.The Common ThreadAcross every single one of these conditions — heart disease, stroke, cancer, Alzheimer's, diabetes, kidney disease, respiratory disease, immune function, mental health — the same five levers keep showing up: diet, exercise, sleep, toxin reduction, and blood sugar balance.Your daily habits are either building disease or building resilience. Every meal, every walk, every night of good sleep compounds — just like interest in a bank account.This Week's Action Plan* Do a food audit. For the next three days, write down everything you eat. No judgment, just awareness — you can't change what you can't see.* Walk 30 minutes a day. It lowers blood pressure, improves insulin sensitivity, boosts BDNF, and reduces cortisol. Simple, not easy — do it anyway.* Optimize your sleep. Consistent bedtime, dark room, cool temperature, no screens.* Get your labs done. Know your fasting glucose, A1C, CRP, vitamin D, triglycerides, and LDL — these are your early warning systems.* Address one stress source this week. A conversation you need to have, a boundary you need to set, or ten minutes of breathwork. Chronic stress is silently killing you — take action on it.Ready for a Real Plan?If you're ready to take your health seriously and want a clear roadmap instead of guesswork, book a Metabolic Blueprint Session. In 30–45 minutes, we'll walk through your top three priority areas and how programs like the Metabolic Momentum Accelerator, the Cellular Reboot Accelerator, and the Total Health Restore Protocols can help.Schedule your complimentary consult →Know someone this could help? Share this episode with them — it might change or even save their life.If this episode was valuable, leaving a review on Spotify or Apple Podcasts helps this show reach more people.ReferencesStudies and sources cited in this episode:* CDC — Leading Causes of Death data* Journal of the American Medical Association (JAMA) — poor diet and US mortality* Ornish, D. et al. (1990) — The Lifestyle Heart Trial* Journal of the American College of Cardiology (2019) — plant-predominant diet, exercise, and cardiovascular risk reduction* DASH diet research on blood pressure control* World Health Organization (WHO) — cancer preventability estimates* American Institute for Cancer Research — lifestyle and cancer risk* The Lancet (2022 meta-analysis) — dietary patterns and cancer deaths* Physical activity and cancer risk study (2019, ~1.4 million participants)* Seyfried, T., Boston College — cancer as a metabolic disease* Bredesen, D., Journal of Aging — the ReCODE Protocol; 2014 case series* BDNF and exercise study (2020) — dementia risk reduction* Mediterranean-MIND diet and cognitive aging research* Harvard Study of Adult Development (80-year longitudinal study) — relationships and longevity* DiRECT Trial, The Lancet (2019) — type 2 diabetes remission through dietary intervention* Frankl, V. — Man's Search for MeaningThis article summarizes claims and studies as presented in the podcast episode. Listeners are encouraged to review primary sources directly and consult their own physician before making health decisions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit tripleplaydoc.substack.com/subscribe

We tend to think of genius as something you're born with. A rare quality possessed by people with extraordinary memories, mathematical abilities, or problem-solving skills.But what if many of the abilities we associate with genius can actually be trained?In this episode, I'm joined by Nelson Dellis, a six-time USA Memory Champion, Guinness World Record holder, and author of Everyday Genius, about the practical skills we can all develop to make better use of our minds.Nelson explains how he went from having what he describes as a fairly ordinary memory to becoming one of the world's top memory athletes. He shares the techniques he uses to memorise enormous amounts of information, including numbers, names and lists, and explains why the ability to remember information still matters in an age when we can ask our phones or AI to retrieve almost anything for us.We also get into mental maths, problem-solving, curiosity, intuition and the fascinating question of whether our minds may be capable of more than we currently understand.Show HighlightsHow Nelson became interested in memory after watching his grandmother struggle with Alzheimer'sWhat it actually takes to become a competitive memory athleteWhy Nelson believes memory is a skill that can be trained rather than a fixed abilityThe SEE, LINK, GO framework for remembering almost anythingHow to build and use a memory palaceHow to remember people's names — and why most of us forget them in the first placeWhy making information vivid, unusual and even ridiculous helps it stickHow to remember lists, speeches, numbers and everyday tasksWhy reviewing and practising memory techniques eventually makes them feel almost automaticHow to develop better number sense and perform calculations in your headWhy mental arithmetic is worth practising when we have calculators in our pocketsHow curiosity can play a role in developing intelligenceWhether technology and AI are making us mentally weaker or simply changing the way we thinkNelson's thoughts on intuition, dreams and remote viewingWhy exercising your brain can be approached much like exercising your bodyThe Big IdeaOne of the most interesting ideas in this conversation is that genius may be less about having an extraordinary brain and more about learning how to use an ordinary brain extraordinarily well.Nelson's own story is a good example. He didn't grow up believing he had a remarkable memory. He discovered techniques that worked, practised them, and gradually transformed his abilities.The lesson is encouraging: there may be considerably more room for improvement in our mental abilities than we assume.Try This Memory TechniqueNelson's SEE, LINK, GO system provides a simple starting point.SEE: Turn the information you want to remember into a vivid mental image.LINK: Connect that image to something else you already know or to a specific location.GO: Retrieve the information by mentally returning to that image or location.The stranger, more vivid, emotional or humorous you can make the mental image, the better.Try it the next time someone gives you a short list of things to remember. Instead of repeating the list over and over, turn each item into an exaggerated mental picture and link the pictures together.You may be surprised by how much easier they are to recall.Resources MentionedEveryday Genius by Nelson DellisNelson Dellis's work on memory and mental performanceMemory palacesMemory competitionsMental mathematics and number senseIntuition, dreams and remote viewingConnect With Nelson Dellishttps://www.nelsondellis.com/Find out more about Nelson, his memory techniques and his work through his website and social channels.And if you enjoyed this episode, subscribe to the podcast, leave a review, and share it with someone who would enjoy learning how to get more out of their own mind.Final ThoughtYou don't have to be born a genius.You can train your memory. You can improve your focus. You can become better at solving problems. You can develop your curiosity.The question isn't simply “How smart am I?”It's “What could I become better at if I actually trained it?”Question or comment? Send us a text message.www.undercurrentstories.com

Recently, a dear friend asked me: "Do you and your husband actually get along all the time? Tell me the truth." So this week on Laugh Lines, we are pulling back the curtain on what it's actually like to be married, raise kids, AND work together every single day. We talk about the things we'll probably never agree on, why I have decision fatigue, and how sometimes it's okay to go to bed angry.We also get an update on Penn's Alzheimer's prevention journey. He recently overdid it at the gym and developed rhabdomyolysis, but what doctors learn from his bloodwork could have important implications for how new Alzheimer's blood tests are interpreted. Plus, we hear from you about the Gen X movies that hit VERY differently when you watch them with your kids. Clueless, Spaceballs, and Stand By Me. (Listen, it was a different time!)Finally, one thing we don't always agree on is what videos we make. So we also ask our Laugh Liners to let us know: Should we publish Penn's "Peeing In The Pool" parody? Buckle up for the world premiere right here on Laugh Lines. The decision is up to you! We love to hear from you! Leave us a message at 323-364-3929 or write the show at podcast@theholdernessfamily.com. You can also watch our podcast on YouTube.Pre-order Get It Done & Have FunVisit Our ShopJoin Our NewsletterFind us on SubstackFollow us on InstagramFollow us on TikTokFollow us on FacebookLaugh Lines with Kim & Penn Holderness is an evolution of The Holderness Family Podcast, which began in 2018. Kim and Penn Holderness are award-winning online content creators known for their original music, song parodies, comedy sketches, and weekly podcasts. Their videos have resulted in over three billion views and over nine million followers since 2013. Penn and Kim are also authors of the New York Times Bestselling Books, ADHD Is Awesome: A Guide To (Mostly) Thriving With ADHD and All You Can Be With ADHD. They were also winners on The Amazing Race (Season 33) on CBS. Laugh Lines is hosted and executive produced by Kim Holderness and Penn Holderness, with original music by Penn Holderness. Laugh Lines is also written and produced by Ann Marie Taepke, and edited and produced by Sam Allen. It is hosted by Acast. Thanks for listening!00:00 Welcome to Laugh Lines!2:57 Do We Get Along16:01 Creative Differences20:08 Should We Post This?25:41 Things We Never Agree On30:45 Penn's Gonna Talk About Alzheimer's41:20 Reflecting On Gen X Movies Hosted on Acast. See acast.com/privacy for more information.

In this episode of Revolution Health Radio, Chris Kresser sits down with renowned neurologist and bestselling author Dr. David Perlmutter to discuss the emerging science of microglia—the brain's immune cells—and why they may hold the key to preventing cognitive decline and Alzheimer's disease. Drawing from his new book, Brain Defenders, Dr. Perlmutter explains how lifestyle factors such as nutrition, exercise, sleep, metabolic health, and gut health influence whether microglia protect the brain or contribute to chronic inflammation and neurodegeneration. Together, they challenge the outdated notion that dementia is largely predetermined by genetics, highlighting growing evidence that proactive lifestyle interventions can preserve—and even improve—brain function throughout life. The post RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter appeared first on Chris Kresser.

What does it really mean to be part of The Sandwich Generation? This is a really personal one for me and I'm honored to welcome back Jill McNamara, LICSW, Vice President of Senior Care at Care.com and a senior care and aging expert, to talk about the emotional realities of caring for aging parents while raising a family. Following the release of Care.com's first-ever Sandwich Generation Report, Jill shares insights from a survey of 1,000 caregivers, revealing just how common and often invisible this experience has become. Together, we get into why so many caregivers don't recognize themselves as caregivers until they're already overwhelmed, the emotional weight of decision fatigue and anticipatory grief, why asking for help can feel so difficult, and the surprising personal growth that can emerge through caregiving. I open up about what's currently going on as my siblings and I continue to navigate our mom's Alzheimer's diagnosis and all the difficult decisions that comes with it as we figure out the best way forward. Whether you're currently caring for aging parents or simply want to be better prepared for the future, this conversation offers practical guidance, reassurance, and a powerful reminder that you don't have to navigate caregiving alone. To learn more, explore Care.com's 2026 Sandwich Generation Report and caregiver resources at care.com/sandwich, and follow @WeAreTheSandwichGen for ongoing support and practical tips. And if you're looking for care for your own family, whether that's childcare, senior care, or anything in between, you can use code WHITNEY35 for 35% off a Care.com membership.This episode is brought to you by Starbucks:At Starbucks, full- and part-time baristas can build meaningful careers, while getting industry-leading benefits. Learn more at Starbucks.com/partnersThis episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct, or indirect financial interest in products, or services referred to in this episode.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Yvette Nicole Brown and Keke reunite for a heartfelt conversation filled with laughs, memories, and surprises. Yvette opens up about marrying at 53, caring for her father through Alzheimer's, speaking up for what she believes in, and whether a Community movie is finally happening. They revisit Drake & Josh, relive their viral Password “Titanic” moment, and Lady Miss Jacqueline makes a surprise appearance to celebrate their new Audible series, The Weddings of Lady Miss Jacqueline.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Patrick brings the question of Sunday Mass front and center, tackling what happens when someone knowingly skips and clearing up confusion straight from the Catechism. He fields listeners’ tough scenarios (baseball games, illness, caring for aging parents) and draws a sharp line between true obstacles and mere preference, even addressing arguments about “man-made” laws with a blunt challenge for sincerity. Listeners throw in questions about deaconesses, godparent choices, and offering up suffering, and Patrick responds with direct, practical advice and scriptural clarity. George – Is it a mortal sin if you intentionally miss mass on Sunday? (00:25) Marlene (email) - What would you say to someone who says missing Mass is a man-made law therefore excusable? (09:33) David (email) - I fear I may have to lie on a life insurance medical survey (13:01) Dee - My son has a mental illness, and he gets paranoid when there’s a large gathering, so he doesn’t go to Sunday mass. (17:29) Joe - I do not attend mass in person, but I do watch mass on YouTube? (19:23) Stephanie - The choice of a godparent should not be honorarium. They should be practicing Catholics and not in mortal sin. (22:49) Jonathan - When will the Church celebrate the Feast of Tabernacles mentioned Zechariah 14? (24:44) Martin - I have the same situation as previous caller about Alzheimer's mother and bringing her to mass after many years. (31:20) James (email) – Women in the diaconate (35:14) Sarah (email) - How should I handle it if my ex-Catholic stepdad (who believes baptism alone lets him receive) wants Communion at Mass with me, given past conflicts and my need to respect the Eucharist without judging him? (44:43)

¿Cuándo fue la última vez que te hiciste un examen de la vista?En este episodio de Café en Mano Podcast me siento con el Dr. Ernesto Collazo, oftalmólogo y cirujano especializado en cataratas, para hablar de algo que va mucho más allá de los ojos.Hablamos de cómo un examen oftalmológico puede detectar diabetes, hipertensión, colesterol elevado e incluso señales tempranas de Alzheimer, años antes de que aparezcan síntomas. También conversamos sobre cataratas, cirugía láser, luz azul, sueño, inteligencia artificial, Neuralink, el futuro de la medicina y por qué Puerto Rico sigue perdiendo médicos especialistas.Si quieres vivir más años, prevenir enfermedades y entender cómo cuidar tu salud antes de que sea demasiado tarde, este episodio es para ti.En este episodio hablamos sobre:* Cómo detectar Alzheimer mirando la retina.* La prueba de sangre que todo adulto debería pedir una vez al año (A1C).* Diabetes silenciosa y retinopatía diabética.* Cataratas: causas, prevención y cirugía.* ¿La luz azul realmente afecta el sueño?* Mitos sobre espejuelos, miopía y cirugía láser.* Inteligencia Artificial, Neuralink y el futuro de la oftalmología.* La escasez de médicos en Puerto Rico.☕ Este episodio es traído por Café Dos CaminosEl café 100% puertorriqueño que llega directo a tu casa.cafedoscaminos.comUsa el código CAFÉENMANO para obtener un 10% de descuento.⚡ Gracias también a FUSE Telecom por mantenernos conectados episodio tras episodio.Suscríbete, comparte este episodio y activa las notificaciones para más conversaciones con expertos en salud, negocios y desarrollo personal.00:00 Introducción e IV Liv02:20 ¿Qué hace realmente un oftalmólogo?04:00 El 70% descubre su enfermedad cuando ya es demasiado tarde07:15 La prueba A1C que todo el mundo debería hacerse10:22 Miopía, astigmatismo y cómo funciona el ojo14:40 Luz azul, pantallas y calidad del sueño18:30 Los problemas más comunes que llegan al oftalmólogo20:50 Cirugía láser: ¿vale la pena?24:38 Cómo un examen de los ojos puede detectar Alzheimer27:30 Diabetes, hipertensión y colesterol vistos desde la retina30:40 Cataratas: causas, prevención y cirugía36:00 Mitos sobre la vista y la nutrición41:30 ¿Por qué hacen falta tantos oftalmólogos en Puerto Rico?48:30 Inteligencia Artificial, Neuralink y el futuro de la medicina58:30 ¿Cómo será la medicina dentro de 10 años?1:07:00 Reflexión final y consejos para cuidar tu salud

For those with family members struggling against dementia or Alzheimers, the two most terrifying words in our language are, "They forgot." Today we're discussing a kind of spiritual dementia that people can suffer from because they fail to heed the warning signs.

En el programa de hoy hablamos sobre el consuelo que Dios ofrece a quienes atraviesan pérdidas, dolor emocional y circunstancias familiares complejas. Acompañamos a nuestros oyentes en temas como el duelo, la salud emocional, la recuperación de adicciones, el cuidado de padres ancianos, decisiones familiares difíciles y la búsqueda de una comunidad espiritual saludable. Un espacio para recordar que Dios está cerca de los quebrantados de corazón y que nunca tenemos que caminar solos en medio del dolor.¿Cómo recuperar la paz cuando siento que he perdido el control de mis emociones?¿Cómo pueden los cristianos afrontar el duelo y la pérdida de seres queridos?¿Cómo convencer a un hijo adulto de que busque atención médica?¿Puedo asistir a Alcohólicos Anónimos y al mismo tiempo acercarme a Dios?¿Debo asistir a la boda de mi hijo homosexual?¿Cómo discernir si una comunidad cristiana es saludable y qué hacer si mi esposo no quiere salir de ella?¿Es normal sentir culpa por no poder cuidar personalmente a una madre con Alzheimer?

More than 90 active wildfires are burning across British Columbia, with tens of thousands forced from their homes (many of which are destroyed). It's prompted a province-wide state of emergency, yet B.C.'s not alone. More than 300 wildfires are active across Canada as we record this conversation with award-winning environmental journalist Arno Kopecky (3:00), who lays out the reality of the situation, what it'll take to turn around the "wildfire season" trend, and the political implications of it all. Feature interviews on Real Talk are presented by Mercedes-Benz Edmonton West.  THIS EPISODE IS PRESENTED BY RapidEX FINANCIAL. THE CRYPTO WORLD MOVES FAST, AND YOUR TRUST IN AN EXCHANGE SHOULDN'T BE A GAMBLE. RapidEX IS SECURE, FINTRAC-REGISTERED, AND NON-CUSTODIAL. SAVE 50% ON FEES ON ONLINE INTERAC E-TRANSFER TRADES WITH PROMO CODE RYAN50 AT https://rapidexfinancial.com/. MBEW: https://www.mercedes-benz-edmontonwest.ca/ 1:19:30 | Arno takes us into his reporting for Maclean's on B.C.'s Cowichan decision and what it means for property owners in the Lower Mainland and beyond. We wrap with touching insights on Alzheimer's and Dementia (1:36:10), which prompted Arno's National Magazine Award-winning essay for The Walrus.  ARNO'S PIECE on MARK CARNEY and CLIMATE CHANGE: https://thewalrus.ca/carney-endorses-pipeline/ ARNO'S COWICHAN PIECE: https://macleans.ca/longforms/richmond-cowichan-land-claim/ A SON, A SCIENTIST, and THE SECRET OF BIOLUMINESCENCE: https://thewalrus.ca/a-son-a-scientist-and-the-secret-of-bioluminescence/ OUR JUNE 2023 INTERVIEW with JOHN VAILLANT on A HOTTER, MORE FLAMMABLE WORLD: https://rtrj.info/062023JV OUR JULY 2026 INTERVIEW with BRANDI MORIN on ALBERTA SEPARATION and TREATY RIGHTS: https://rtrj.info/072426Brandi REAL TALK'S LIVE CHAT IS POWERED BY PARK POWER. SAVE on INTERNET, ELECTRICITY, and NATURAL GAS: https://parkpower.ca/realtalk/ REAL TALK'S LIVE STREAM IS PRESENTED BY CALIFORNIA CLOSETS. BOOK YOUR FREE CONSULTATION: https://californiaclosets.ca/ REAL TALK HIGHLIGHTS ARE PRESENTED BY KUBY ENERGY AND CANADIAN GREEN TECH, YOUR TRUSTED SOLAR PROVIDERS. LEARN MORE AT https://kuby.ca/ or in-store at Costco. SIGN UP for YEGplus, CANADA'S FIRST AIRPORT REWARDS PROGRAM: https://yegplus.com/realtalk SAVE 10% on ONLINE MEN'S CLOTHING PURCHASES at THE HELM with promo code REALTALK: https://thehelmclothing.com/ FOLLOW US ON TIKTOK, X, INSTAGRAM, and LINKEDIN: @realtalkrj & @ryanjespersen JOIN US ON FACEBOOK: @ryanjespersen REAL TALK MERCH: https://ryanjespersen.com/merch RECEIVE EXCLUSIVE PERKS - BECOME A REAL TALK PATRON: patreon.com/ryanjespersen THANK YOU FOR SUPPORTING OUR SPONSORS! https://ryanjespersen.com/sponsors The views and opinions expressed in this show are those of the host and guests and do not necessarily reflect the position of Relay Communications Group Inc. or any affiliates.

Conscious Caregiving with L & L is "Tackling the Tough Conversations."   The topic of this episode is "Covering Care Costs" featuring hosts Lori La Bey and Lance A. Slatton.   About Lori La Bey:   Lori La Bey is the founder of Alzheimer's Speaks and is co-founder of Dementia Map global resource directory and the co-host of Conscious Caregiving with L & L.   Lori's mother who lived with dementia for 30 years. Her goal has always been to shift dementia care from crisis to comfort around the world.   She offers a variety of free resources to educate, empower, connect, and decrease stigmas; helping families and professionals live graciously alongside dementia.   Lori is an international speaker known for her multiple platforms and training programs.   About Lance A. Slatton - known as "The Senior Care Influencer"":   Known as "The Senior Care Influencer" Lance is a Writer, Author, Influencer, and Healthcare professional with over 20 years in the healthcare industry.   Lance A. Slatton is a senior case manager at Enriched Life Home Care Services in Livonia, MI. He is also host of the award winning podcast & YouTube channel All Home Care Matters and Co-Host of Conscious Caregiving with L & L with Lori La Bey along with The Care Advocates and The Caregiver's Journal.   Lance is also the new President of AlzAuthors.   Lance's book, "The All Home Care Matters Official Family Caregivers' Guide" was the recent recipient of the 2024 International Impact Book Awards.   To learn more about Lance A. Slatton and Lori La Bey you can visit their websites.

I interviewed Kate Voet & Victor Maes about A Long Goodbye on Saturday, August 30, 2025 at Venice Immersive in Venice, Italy. Here is the story synopsis for A Long Goodbye: "A Long Goodbye tells the story of Ida, a 72-year-old pianist living with dementia. In this animated, interactive VR experience, we walk in Ida's shoes. We experience a day in her life, as her reality is fading. The apartment, where she spent a lifetime with her beloved husband Daniel, first feels empty and undefined. When we interact with objects and play the tape recordings of her husband, her playful world gradually comes to life, as if drawn in paint before our eyes. Like pieces of a puzzle, memories and conversations help Ida to rediscover herself. But we also discover Daniel's struggles, as he hopes to stay connected and realises their remaining time together may be short. A Long Goodbye is a poetic experience about the impact of dementia, but above all it is about love and the long goodbye of two lovers who shared a life together." Here are the contextual domains that are explored: Self and Identity [1], and the loss [8] of memory [1]. All the ways that we capture and record our identity [1]. "Like pieces of a puzzle, memories and conversations help Ida to rediscover herself." Artifacts of shared experiences and memories shared within the spatial context of a home [4], Husband [7] caretaker [7] of the main character with Ida, "72-year-old pianist living with dementia." Music [5], wihch was a part of her career [10], and the various adventures they had together [9] Here is the Elemental Center of Gravity: 1st Center of Gravity of Emotional Presence: Narrative-driven, animation with lots of immersive & interactive components. The pacing is gated with interactive actions, and the movement of your body seamlessly blends into various things like change blindness edits. An incredible score with different themes for different characters, and the world starts to change and dissolve as the main protagonists memory also fades giving you a sense of time, and unfolding processes. Victor is also a cinematographer, and so there's lots of canny translations of cinematic grammar into an emerging spatial grammar. VERY EMOTIONALLY IMPACTFUL2nd Center of Gravity of Earth Element / Environmental and Embodied Presence: An incredibly transportative world with a very distinct water coloreque aesthetic. Lots of embodied movement through this piece. Also some mashing up of contexts between these worlds that is reminescent of Meow Wolf. There's quite a lot of void space to help direct attention, but also makes excellent use of available space. There's physical movements paired with virtual locomotion. And the physical installation with post-it notes also helped created a strong magic cirlce for the piece. You are also embodied as Ida - as you learn about yourself as she has to do each and every day. From their artist statement, Kate and Victor said, "When we put the VR headset on, the first questions that come to mind are: Who am I? And where am I? This confusion is exactly what our protagonist is dealing with and this became the starting point of the story."3rd Center of Gravity of Fire Element / Active Presence: Interactions that gate the narrative in order to help modulate the pacing of the story. Free to physically move within space, but also paired with virtual locomotion. They aspired to allow people to be able to wander through the story and you get a bit lost along the way. So TRUE!4th Center of Gravity of Air Element / Mental and Social Presence: Dialogue amongst the characters, and also tape recording. Nice blend of metaphoric memory and dream logic with an amazingly well-written script. But also a puzzle-like structure as you piece together the story. Archetypal Themes and Character Explored: Memory. Loss, Grief, Death. The slow dissolving of the structures of memory as reflected within the sparse void-like architecture of the piece itself reflecting this slipping away into liminality. The love that they share within their partnership. "a poetic experience about the impact of dementia, but above all it is about love and the long goodbye of two lovers who shared a life together." So talking about the details of the condition, but also the caretaker / partner who is living with this condition "A Long Goodbye is at once a personal and a universal story about human connection. It serves as a reminder that people are always so much more than their illness. Instead of focusing on what is lost, we need to stay close and hold on to shared affection." Artist Statement: "When we put the VR headset on, the first questions that come to mind are: Who am I? And where am I? This confusion is exactly what our protagonist is dealing with and this became the starting point of the story. We were drawn to this theme because of Victor's grandfather who lived with Alzheimer's disease, and whose health declined rapidly after Victor's grandmother passed. The experience of having witnessed this emotional transformation close by, made us explore how dementia is experienced and how it influences the relationship with your past, with yourself and with your loved ones. A Long Goodbye is at once a personal and a universal story about human connection. It serves as a reminder that people are always so much more than their illness. Instead of focusing on what is lost, we need to stay close and hold on to shared affection." https://www.youtube.com/watch?v=9-kttoua1PA This is a listener-supported podcast through the Voices of VR Patreon. Music: Fatality

Hey, it's Amy Newmark with your Chicken Soup for the Soul and I'm excited about sharing stories with you from Chicken Soup for the Soul: Care for the Caregiver. The stories in this book provide support and tips and plenty of humor for people who are involved in caregiving for family members with dementia, whether it's Alzheimer's or one of the other kinds. These stories are incredibly helpful to someone who is starting to navigate the caregiving journey, and they are also helpful and supportive for people who have been doing it for years, because it DOES go on for years. Everyone can benefit from the wise words and the humorous anecdotes shared by people who have been there, done that, and maybe are still in the middle of doing it. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Detroit is not playing around when it comes to dementia support, and we want you to see what we saw. We're pulling back the curtain on our second Parenting Up tour stop in Detroit with Wayne State University and the team that helped make this three-part run happen. Along the way, we share the little moments that make tour life feel real plus the big moments that make you rethink what “living with dementia” can look like.The theme is simple and bold: Detroit cares about dementia. We talk about why it matters to hear directly from people living with dementia, especially when so many are still working, driving, and finding ways to live fully. Their courage challenges the stigma that keeps families quiet and isolated. We also dig into dementia-friendly communities and safe public spaces, from Alzheimer's Association advocacy to faith communities building routines, training volunteers, and making everyday places feel welcoming instead of scary.We also get practical about early detection and cognitive testing. We unpack what “baseline” means, why clinics and outreach programs can help, and how inexpensive screening can give you something every caregiver needs more of: options. Knowledge really is power when you're trying to plan care, protect independence, and make decisions on your own terms.If you're a caregiver, a family member, or just trying to understand Alzheimer's awareness without the doom, come ride with us and take what works back to your own community. Subscribe, share this with someone who needs it, and leave a review so more families can find us.Support the show"Alzheimer's is heavy but we ain't gotta be!"IG: https://www.instagram.com/parentingupFB: https://www.facebook.com/parentingupYT: https://www.youtube.com/@parentingupTEXT  'PODCAST"  to  +1 404 737 1449  - to give J topic ideas, feedback, say hi!Be sure to leave us a review! 

In this episode of the MindHealth360 Show, I sit down with Judy whose remarkable journey has challenged long-held assumptions about Alzheimer's disease and cognitive decline. Diagnosed with Alzheimer's at the age of 67 after watching her mother and four uncles die from the disease, Judy believed her future had already been written. Instead, she became Dr. Dale Bredesen's 'patient zero' – his first human patient to follow the personalised precision medicine approach that would later become the RECODE Programme. Together, they explored whether identifying and addressing the many factors contributing to cognitive decline could alter the course of the disease. Judy's experience went on to help shape one of the most widely discussed personalised approaches to Alzheimer's disease. Together, we explore why Alzheimer's may not be driven by a single cause, but by a combination of underlying factors that differ from person-to-person. Judy explains how nutrition, sleep, exercise, stress reduction, detoxification and other personalised interventions became the foundation of her approach and why consistency has been just as important as the interventions themselves. Fourteen years after her diagnosis, at the age of 81, Judy is fitter, healthier and cognitively sharper than ever. To prove it, she walked 3,000 miles across America to raise awareness of Dr. Bredesen's work and to share a message of hope for others facing cognitive decline. Now, at 82, she is currently walking from Land's End to London, across the UK.. Her extraordinary and inspirational story invites us to reconsider what is possible when cognitive decline is addressed through a personalised, whole-person approach. In this episode, you'll learn: What it was like to receive an Alzheimer's diagnosis after watching dementia affect five close members of Judy's family. How Judy became Dr. Dale Bredesen's 'patient zero' and helped inspire the personalised approach that became the RECODE Programme. Why Alzheimer's may be driven by multiple underlying factors rather than a single disease process. Why identifying and addressing those underlying factors supports better brain health, and better overall health. Why early intervention, lifestyle changes and long-term consistency have been central to Judy's experience. How Judy went from an Alzheimer's diagnosis at 67 to walking 3,000 miles across America at the age of 81 and now, at the age of 82, Judy is walking 530 miles across the UK. What Judy's story reveals about emerging precision medicine approaches to cognitive decline. Why Judy believes hope and taking an active role in your health makes all the difference. Take the conversation further at IMMH 2026 At this year's Integrative Medicine for Mental Health (IMMH) Conference, Judy Benjamin will join Dr. Kat Toups, Dr. Dale Bredesen and Dr. Richard Horowitz for a dedicated session on reversing cognitive decline through personalised, precision medicine. The session will explore groundbreaking results from a randomised controlled trial of precision medicine in Alzheimer's disease, alongside the clinical approaches being used to identify and address the individual drivers of cognitive decline. Join Judy and leading experts in neurodegeneration at IMMH 2026, October 8–11 in San Diego.

A viral documentary sent thousands of people rushing to pull their teeth. The theory behind it — the focal infection theory — dates back to a dentist in the 1920s named Weston Price, was largely rejected by the mid-twentieth century, and yet has roared back to life on the internet with enough force to create genuine panic. Dr. Chris Motley isn't here to add to that panic. He's here to do something more useful: look at the science and arguments behind both sides of the issue, and surface the conversation about oral health and the whole-body connection that nobody in mainstream dentistry wants to have. In this episode you'll discover: The focal infection theory explained — where it came from, why it was rejected, and why it went viral again a hundred years later The verified research finding that should be in every dentist's waiting room: oral bacteria linked to Alzheimer's disease has been found in patients' brains, and gum bacteria has been found in heart arteries What the meridian tooth chart is — the ancient Chinese medicine map that connected every single tooth to a specific organ thousands of years before modern diagnostics existed How EAV testing (electroacupuncture according to Voll) measures the electrical conductivity of meridian points — and what it reveals about the organ connected to a tooth with a root canal Why some patients live perfectly well with root canals — and the acupuncture assessment Dr. Motley uses to determine when a tooth is creating systemic stress and when it isn't The truth about metal fillings and mercury vaporization — and why drilling out a stable filling could actually cause more harm than leaving it in place Why a cone beam 3D scan reveals hidden infections that a standard flat dental X-ray completely misses The questions Dr. Motley recommends asking your dentist before agreeing to a root canal — including whether the nerve is still alive and what happens if the procedure fails How MicrogenDX oral testing screens for over 50,000 bacterial species in the mouth — and why standard dental culture tests miss the vast majority of what's living there The oral bacteria most strongly linked to gingivitis, Alzheimer's disease and cardiovascular disease — and the herbal protocol Dr. Motley uses to reduce bacterial load naturally Why oil pulling with coconut oil, Golden Thread Supreme, Melia Supreme and Noni (Morinda) are Dr. Motley's go-to tools for oral microbiome health How the lung meridian connects to skin health, and what sores or chronic inflammation inside the nostrils are actually signalling about deeper organ function Why finding a dentist who understands and respects the mouth-body connection is Dr. Motley's single most important first step for anyone dealing with chronic oral or dental health issues Whether you have a root canal already, are considering one, or have simply been told your teeth are fine while the rest of your body isn't — this episode will permanently change the way you think about your mouth. Products and Testing Mentioned: MicrogenDX oral bacterial testing — microgendx.com Golden Thread Supreme — Supreme Nutrition Products: https://shorturl.at/qmIIX Melia Supreme — Supreme Nutrition Products: https://shorturl.at/7eaTX Noni / Morinda Supreme — Supreme Nutrition Products: https://shorturl.at/7NgJm Cone Beam CT Scan — ask your biological or holistic dentist Disclaimer: This episode is for educational and informational purposes only and does not constitute dental or medical advice. Dr. Motley is not a dentist. Always consult a qualified dental professional before making any decisions about your oral health care. 00:00 The documentary that scared everyone about their teeth 02:20 Weston Price and the era of the tooth pull 05:20 What a root canal actually does 08:28 One mile of branching: the case against 11:40 What the heart research really shows 13:24 Four questions to ask before you consent 14:30 Reading the body's electrical current 15:59 The meridian tooth chart 16:38 If it is not broken, do not fix it 17:20 Metal fillings and the mercury argument 19:51 Gum bacteria in the Alzheimer's brain 20:43 How to actually test your mouth 23:00 The woman who could not swallow 25:55 My own cracked tooth, and what it meant 28:06 Teeth conduct electricity 29:49 Every tooth, every organ: the full map 32:00 What to do about it 34:33 Take your mouth seriously Want more of The Ancient Health Podcast? Subscribe to the YouTube channel. ------  Follow Doctor Motley! Instagram TikTok Facebook Website ------  *You can get cell support in gummy form: Mitopure now starts at $79, when you go to timeline.com/DRMOTLEY. *Join Doctor Motley's newsletter for TCM insights and regular podcast updates https://www.doctormotley.com/ *Do you have a ton more in-depth questions for Doctor Motley? Check out his course on emotions and the body in his membership. You'll find other courses full of his expertise and clinical wisdom, plus bring all your questions to his weekly lives! To try risk-free for 15 days click here https://www.doctormotley.com/15

Alzheimer, demencia, pérdida de memoria, cuidadores y duelo anticipado: ¿qué pasa cuando alguien que amas empieza a irse poco a poco, aunque todavía esté frente a ti? El actor, Alan Slim, nos comparte su experiencia sobre el Alzheimer de su papá y el impacto profundo que esta enfermedad tiene en toda la familia. Una conversación íntima sobre las primeras señales del Alzheimer, el dolor de cuidar, la culpa de soltar, las decisiones difíciles y el amor que aprende a acompañar sin discutir, sin confrontar y sin romperse por dentro. Si tú o alguien que conoces está viviendo el Alzheimer, la demencia o el cuidado de un adulto mayor, este episodio puede ayudarte a mirar este proceso con más compasión, información y amor. Este episodio nos recuerda que nada está garantizado, ni la memoria, ni el tiempo, ni las personas que amamos. Por eso 21 Días de Gratitud es una invitación a hacer una pausa, volver al presente y agradecer hoy lo que ya forma parte de tu vida.

Alzheimer's disease doesn't happen overnight. In many cases, the changes that contribute to cognitive decline can begin decades before symptoms appear, which means the choices you make today may have a meaningful impact on your brain health in the future.   The good news is that there are proactive steps you can take to support your brain and reduce your risk of cognitive decline.    On today's show, I break down the Bredesen Protocol and explore the 5 key areas that can help support long-term brain health and healthy aging.   So join me on today's Cabral Concept 3835 to discover the 5-part protocol for supporting your brain, reducing your risk of cognitive decline, and taking a more proactive approach to Alzheimer's prevention.   Enjoy the show, and let me know your thoughts!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3835 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!