Podcasts about CRISPR

Imaginez la scène : un poisson préhistorique, il y a des centaines de millions d'années. À cette époque, pas de doigts, pas de mains, juste des nageoires. Et pourtant, selon une étude publiée le 17 septembre 2025 dans la revue Nature, c'est dans cette créature aquatique qu'il faut chercher l'origine… de nos doigts. Et, encore plus étonnant, le secret se cache dans un organe qu'on n'aurait jamais soupçonné : son anus, ou plutôt son cloaca, cette ouverture unique qui servait à la fois à digérer, à uriner et à se reproduire.L'étude a révélé quelque chose de fascinant. Les chercheurs ont identifié un ensemble de séquences génétiques appelées “paysages régulateurs”. Ces petites régions d'ADN ne fabriquent pas de protéines, mais elles contrôlent l'activité de gènes essentiels. Parmi eux, les gènes Hox, qui orchestrent le développement du corps chez l'embryon. Or, chez les poissons, ce fameux paysage régulateur n'était pas du tout lié aux nageoires. Il était actif dans la formation du cloaca.Avec l'outil CRISPR, les scientifiques ont fait une expérience cruciale. Quand ils suppriment ce paysage régulateur chez la souris, les doigts et les orteils ne se forment pas correctement. Mais quand ils le suppriment chez un poisson, les nageoires se développent normalement… tandis que le cloaca, lui, est gravement perturbé. Autrement dit, la machinerie génétique qui a servi à construire nos doigts venait à l'origine d'un système utilisé pour bâtir un orifice digestif.C'est un exemple parfait de ce que les biologistes appellent la co-option évolutive. L'évolution n'invente pas à partir de rien. Elle réutilise des circuits anciens, elle détourne des mécanismes existants pour leur donner une nouvelle fonction. Dans ce cas, un “programme génétique” d'abord destiné au cloaca a été recyclé pour façonner des doigts lorsque nos ancêtres ont quitté l'eau pour marcher sur la terre ferme.Alors, quand vous bougez vos mains ou quand vous pianotez sur un clavier, souvenez-vous que ce geste quotidien porte la trace d'une histoire bien plus ancienne qu'on ne l'imagine. Vos doigts ne sont pas seulement les héritiers des nageoires d'un poisson, mais aussi le fruit d'un bricolage génétique qui, il y a très longtemps, concernait… un anus préhistorique. Voilà une image inattendue, presque poétique, qui nous rappelle à quel point l'évolution sait transformer le trivial en extraordinaire. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Lords: * Danny * https://nightbrunchband.com/ * Walker * https://nightbrunchband.com/ Topics: * You Probably Think This Song is About You * The Perfect r/crappymusic Post: An audio tour of Archetypes * https://media24.fireside.fm/file/fireside-uploads-2024/images/3/3597ddeb-e52e-4cda-a59c-c64600489fea/0291r0zf.png * https://www.youtube.com/watch?v=6EIwP0zerbk * Sample-based film scores in the 80s * https://www.tumblr.com/mogwaipoet/786937779224461312/terminator-2-1991-and-the-princess-bride-1987 * Do Not Stand at My Grave and Weep, by Clare Harner actually * https://en.wikipedia.org/wiki/DoNotStandatMyGraveand_Weep * Being a Video Game Newb in Your 40s Microtopics: * Is it a Topic or is it Just Banter? * Cleaning Lords, Lunch Lords and Cat Lords. * Have you heard the good word about the Gaylady? * Night Brunch. * Wearing your own band's t-shirt. * A thing that could happen for a while and then was no longer able to happen. * Hi Cindy! * Motivating yourself to work harder via self loathing. * Feeling the need to act all angsty so that people take you seriously as an artist. * A Touch of Grandiosity. * How many tracks get uploaded to SoundCloud every day? * Continuing to discover music from the 1970s. * It's called "Topic Lords," not "Correct Lords." * Once it becomes impossible to make new music, and we go back and start listening to all the SoundCloud uploads with 0 listens. * All the kids at Rock & Roll Camp getting excited about Lofey. * Pretending a topic is about one thing when it's actually about something else. * Canadian Actor Dave Coulier. * Tuesday at 3:01pm. * Learning a new chord on your Electric Tenor Guitar. * Bringing Pokemon Puzzle League characters into your love song. * Having a whole week to dial in that wub wub patch. * What art is for and what art should be for. * Fun is our only reward. * The objective best pitch wheel range. * The Funky Worm preset. * Synthesizers that can save and load patches but only when plugged into your phone. * Coming up with a Rube Goldberg machine to upload patches from a web server to your CZ-5000. * thisdx7cartridgedoesnotexist.com * In a convex optimization problem, there is no gradient to descend. * Fiddling with the synthesizer sliders until you reach a corner of the parameter space that doesn't make any noise and giving up. * Camp Counselor Grant hastily drawing all the synthesizer waves on the board. * Ask any Geometer, the triangle has three sides. Love triangles are actually just two love segments. * The All Topic Fakeouts episode. * The gulf between how an artist thinks they're presenting themselves and how they're being received. * A Beautiful Rainbow of the Human Experience. * Elderly rappers with excellent flow but terrible drip. * Piling onto propaganda music. * Someone doing their own thing with confidence and authenticity. * Graffiti with immaculate copyediting. * With improved access to art tools, taste is one of the only things left to get wrong. * Only the best crappy music. * Promoting your music in r/crappymusic. * Tori the Clown Rap Gal. * The audacity of extreme autotune. * All Youtube thumbnails converging on the same cognitive attention hacks. * Singing the comments on your last video. * Situations where echo chamber amplification is fun and good for the world. * Obscure Music That Slaps. * Serbian Kolos. * The Ketron Event Chrom. * The Nightmare Klaxon that Represents Dread. * All the Fairlight CMI presets used in the Terminator 2 soundtrack. * Growing up playing samples at every possible speed in Impulse Tracker. * Slowly sucking dog food out of a can to simulate the sound of a mimetic polyalloy passing through steel bars. * It's been a long day and you're ready to go home but you need to slam 1000 more inverted glasses into bowls of yogurt, let's hurry it up guys. * That one sample library squeaking metal door sound that everyone uses. * Calling out comb filtering whenever you hear someone exhale deeply while sitting down at a desk. * The sound guy instructing all the actors when to breathe to minimize comb filtering. * Rubber Baby Knopfler Romplers. * All the things you are after you die. * The purpose of suffering. (So we can write cool poems about it.) * Making art about how trauma used to exist. * Why wireheading will not solve our problems. (Because everything uses bluetooth now.) * Who needs trauma when we have CRISPR? * Shepherding noobs. * Play Any Video Game Day. * Complicated goose controls. * Trying to play Portal as your first 3D game. * Learning video games vs. learning board games. * Trying to get into video game series that don't change. * Looking at the screen and/or ants until it coalesces into an image. * Video games filled with really gross blood squirt sounds. * Jumping on and off of buildings. * Playing Breath of the Wild and just collecting mushrooms and herbs. * Grass simulation in Breath of the Wild vs. in Horizon Zero Dawn. * Putting yourself in the head-space of the protagonist in order to do protagonist stuff. * Spelling brunch the secret way.

When Jesus said the End Times would be as the Days of Noah, one thing He was getting at is genetic tampering with the human race Pastor Gene Pensiero Find audio, video, and text of hundreds of other prophecy updates at: https://calvaryhanford.com/prophecy Read along with us at https://calvaryhanford.substack.com Follow us on YouTube at https://youtube.com/calvaryhanford — […]

Join Dr. Paloma Giangrande, Editor-in-Chief of Molecular Therapy Nucleic Acids, as she discusses a recently published MTNA article, Controlling CRISPR-Cas9 genome editing in human cells using a molecular glue degrader, with its authors Drs. Krishanu Saha and Namita Khajanchi (UW-Madison). If you enjoy this episode, check out our hybrid event this fall that will allow you to engage with pioneering researchers in gene editing! Breakthroughs in Targeted In Vivo Gene Editing will be held in San Diego and virtually November 20-21, 2025. Music: 'Electric Dreams' by Scott Buckley - released under CC-BY 4.0. www.scottbuckley.com.auShow your support for ASGCT!: https://asgct.org/membership/donateSee omnystudio.com/listener for privacy information.

In the four years since the book’s publication, CRISPR has revolutionized the world of medical treatments and possibilities. But our world has changed drastically, too. As AI’s impact grows, U.S scientists are facing funding cuts like never before. For our final episode, we bring you a live conversation between Walter Isaacson and Jennifer Doudna at the New Orleans Book Festival. In her own words, you’ll hear Doudna explain how CRISPR blossomed from an idea to a phenomenon, and the challenges scientists faces in this politically fraught moment.See omnystudio.com/listener for privacy information.

A public murder, a public act of forgiveness, and a public reckoning with what courage really costs—this conversation starts where the news won't and moves into the places most of us live: trust, discernment, and the daily habits that shape our conscience. We open with the assassination of Charlie Kirk and the surprising witness that emerged from the memorial—clear gospel, costly grace, and a reminder that God can draw purpose from tragedy without excusing evil. The question beneath the headlines is personal: what risks will we take for truth, and how do we respond when our enemies give us every reason not to love them?From there, we move through the thickets of modern medicine, where vaccine skepticism collides with scientific claims and shifting guidance. Instead of trading slogans, we slow down to practice discernment—separating correlation from causation, weighing evidence, and remembering that loving our neighbor includes doing our homework. That same careful posture anchors a frank look at xenotransplantation, as researchers push the boundaries of pig-to-human organ transplants. We unpack somatic versus germline concerns, the special dignity of human life, and how to balance innovation, transparency, and moral guardrails when the stakes are life and death.Finally, we tackle AI's ethical drift. New studies show the more people rely on AI, the easier cheating becomes and the harder it is to think for ourselves. We share practical ways to use AI without losing integrity—designing assessments that test real understanding, cultivating intellectual friction, and resisting the algorithmic echo chambers that tell us only what we want to hear. Through it all, one thread remains: a call to rebuild the muscles of clear thinking, mercy, and courage so we can serve our neighbors and witness to Christ with honesty and hope.If this resonates, subscribe, share it with a friend, and leave a review to help others find the show. Then tell us: which topic do you want us to dig into next?SHOW NOTES:Pig Lung Xenotransplant to Human: Chinese scientists have successfully transplanted a pig lung into a human being for the first time, with the organ partially functioning before it was removed. Researchers used CRISPR technology to make six gene edits to the left lung of a pig whose organs are roughly human-sized. They transferred the lung into a brain-dead 39-year-old man. Initially, the lung delivered oxygen to his blood and removed carbon dioxide. Within 24 hours, however, signs of damage appeared, and the body began to reject the organ. Scientists ended the experiment following fluid buildup. The patient was removed from life support per his family's wishes. (Source: https://tinyurl.com/24ccpehj  accessed 8-26-25)Which Diseases Will You Have in 20 Years? Using AI Increases Unethical Behavior Support the showThe ministry of Christian Life Resources promotes the sanctity of life and reaches hearts with the Gospel. We invite you to learn more about the work we're doing: https://christianliferesources.com/

In this episode, I talked to Dr. Alexander Marson, cofounder of Arsenal Biosciences and director of the Gladstone-UCSF Institute of Genomic Immunology. He is one of the pioneers of non-viral T-cell editing and is a serial biotech entrepreneur. We talked about Car T-cell Therapy, using CRISPR to edit T-cells, biotech, and his collaboration with Sean Parker, cofounder of Napster. ---------------------------------------------------------------Thanks to the sponsors:Audible: Use my link for a 30-day free trial: http://audibletrial.com/diamondgoatNewsly: https://newsly.mepromo code to receive a 1-month free premium subscription: EARLYMORNING Libysn: https://libsyn.compromo code: DG Dubby Energy: https://www.dubby.ggpromo code for 10% off: DIAMONDGOATOpus Clips:  https://www.opus.pro/?via=diamondgoat----------------------------------------------------------------------------------Listen on:Podcast website: https://www.spreaker.com/podcast/dg-early-morning-show--5943922Spotify: https://open.spotify.com/show/0EuhA6WyuerHtVAqcFrFeOPodcast YT channel clips: https://www.youtube.com/@dgearlymorningshowTiktok: @dgearlymorningshowApple Podcast: https://podcasts.apple.com/us/podcast/dg-early-morning-show/id1575451533Amazon Music: https://music.amazon.com/podcasts/f050b86c-1dad-4bc3-b12f-6aa5fa62438c  Goodpods: https://goodpods.com/podcasts/dg-early-morning-show-211830RadioPublic: https://radiopublic.com/dg-earlymorning-show-WoML4rBreaker: https://www.breaker.audio/dg-early-morning-showReason: https://reason.fm/podcast/dg-earlymorning-show--------------------------------------Check out my other stuff:Instagram: @itzdiamondgoatTwitter: @lildiamondgoatMain YT channel: youtube.com/diamondgoatTiktok: @lildiamondgoatSoundcloud: @Lil DiamondgoatSpotify: @Lil DiamondgoatMerch store: https://diamondgoat.creator-spring.com

Broadcast from KSQD, Santa Cruz on 10-02-2025: Dr. Dawn opens by explaining how blood pressure treatment guidelines have been corrected back to 140/90 after the problematic 2015 SPRINT study temporarily changed recommendations to 120/80. That study used ideal measurement conditions - five minutes of quiet sitting, perfect cuff sizes, compliant patients - creating unrealistic targets that caused elderly patients to faint and break hips. The Veterans Administration and major cardiology organizations now recommend treating to 140/90, with statins only for LDL above 190 or 12% ten-year cardiovascular risk. An emailer asks about claims linking Tylenol to autism. Dr. Dawn thoroughly debunks this, explaining that Swedish studies of 2.5 million children found no association when controlling for sibling comparisons. She notes autism rates remained flat from 1960-1990 despite widespread Tylenol use, then spiked after DSM-4 in 1994 and DSM-5 in 2013 broadened diagnostic criteria. Recall bias skews studies since mothers of autistic children are asked leading questions about past Tylenol use during pregnancy when fever treatment was medically necessary. She discusses RFK Jr.'s mixed positions, comparing him to Isaac Newton who excelled at physics but believed in astrology. While criticizing vaccine misinformation, Dr. Dawn strongly supports RFK's stance on ultra-processed foods. She describes NIH researcher Kevin Hall's studies showing people consume 500 extra calories daily on ultra-processed diets versus whole foods, even when nutrients are matched. The US produces 15,000 calories per person daily, with the food industry engineered to promote overconsumption through hyper-palatable fat-sugar-salt combinations. A caller asks about Healthcare 4.0 plans for biometric tracking bracelets and digital twins. Dr. Dawn discusses privacy concerns around constant health monitoring and data collection, noting that while early disease detection could be valuable, mandatory participation raises serious civil liberties issues. She acknowledges voluntary research projects like the Million Man Study but emphasizes the importance of consent and protection against unauthorized data access by advertisers or government agencies. An emailer shares research on ultrasound brain stimulation helmets as alternatives to surgical electrode implants. Dr. Dawn explains how 256-element phased ultrasonic arrays can target brain regions like the visual cortex with high precision mechanical perturbation, potentially treating Parkinson's, Alzheimer's, and depression without surgery. The technology remains experimental, requiring MRI guidance, but could become portable and dramatically improve quality of life for neurological conditions currently requiring invasive deep brain stimulation. A caller with adrenal cancer asks about fasting-mimicking diets. Dr. Dawn explains that 14-hour fasting before chemotherapy improves outcomes because healthy cells can downshift metabolism while cancer cells cannot. Cancer cells rely only on glycolysis without mitochondrial function, making them vulnerable during fasting states. She recommends chronotherapy - scheduling treatments during fasting periods - and expresses optimism about new cancer therapies like CAR-T cells and CRISPR technologies. An emailer asks about inulin fiber for fatty liver disease. Dr. Dawn explains how this fiber found in chicory, Jerusalem artichokes, and root vegetables stimulates gut bacteria to break down fructose before it reaches the liver, preventing fructose-induced hepatic lipogenesis. Inulin supplementation protects against fatty liver disease, increases antioxidant production, and helps with obesity by reshaping the gut microbiome to better process dietary sugars.

Join Jay Gunkelman, QEEGD (the man who has analyzed over 500,000 brain scans), Dr. Mari Swingle (author of i-Minds), and host Pete Jansons for another engaging NeuroNoodle Neurofeedback Podcast episode discussing neuroscience, psychology, mental health, and brain training.✅ Autism & EEG: Jay and Dr. Mari explore autism's rise, EEG patterns, and why autism isn't “one thing” but a spectrum with genetic clusters and neurophysiological signatures.✅ Dehydration & Mental Health: How hydration, cortisol, and electrolyte balance impact EEG readings, stress, and mental performance.✅ Neurofeedback Setup Essentials: From sleep, hydration, and no gum to avoiding “wet dog” hair — the panel shares real-world stories of EEG prep gone wrong (and right).✅ Additional Topics:

As the gene editing field kept growing, so did the dangers. Back in 2018, Jennifer Doudna received an email from a Chinese scientist claiming that he had genetically edited two twin babies. The news reverberated across the world and made Doudna and her colleagues urgently consider the implications of what their discovery could mean for humanity. Walter Isaacson sits down with Evan and tells him why the field has always been ripe with ethical questions, and how the COVID-19 pandemic pushed researchers to recalibrate their priorities.See omnystudio.com/listener for privacy information.

Explore the transformative impact of artificial intelligence and automation on the produce and floral industries with host Vonnie Estes and guest Joe Don Zetzsche. With insights from Joe's extensive experience, the episode delves into AI's role in reshaping retail, revolutionizing floriculture breeding, and redefining supply chains. Discover strategies for growers and retailers to adapt and thrive amid rapid technological advancements. As AI models grow exponentially, understand how embracing these changes can unlock abundance and sustainability in everyday business practices.Key Takeaways• Exponential Growth Understanding: Joe explains the concept of exponential tech growth and its implications on human understanding and industry evolution.• AI in Retail: AI is revolutionizing retail operations, with companies like Amazon and Walmart leading through data integration and automation.• Impact on Medium and Small Retailers: Smaller retailers may face challenges without strategic adoption of AI technologies, potentially paying other companies to fill those gaps.• AI's Role in Floriculture: AI's integration in breeding processes is leading to more resilient and higher-performing floral varieties, highlighting future potentials for genomics and CRISPR technologies.• Cultural and Economic Shifts: Consumer acceptance of AI-driven services, like delivery of perishables, signals a cultural shift towards automation-enhanced convenience.Guest Resources• Joe Don Zetzsche: Currently supporting the floral and retail industries through consulting.• International Fresh Produce Association (IFPA): Fresh ProduceFor more insights into how AI and technology are reshaping industries, listen to the full episode and stay tuned to “Fresh Takes on Tech” for more thought-provoking discussions.Show LinksInternational Fresh Produce Association - https://www.freshproduce.com/Fresh Takes on Tech - https://www.freshproduce.com/resources/technology/takes-on-tech-podcast/Facebook - https://www.facebook.com/InternationalFreshProduceAssociation/Twitter - https://twitter.com/IntFreshProduce/LinkedIn - https://www.linkedin.com/company/international-fresh-produce-association/Instagram - https://www.instagram.com/intlfreshproduceassn/

We are playing God | Slavoj Žižek and Yuval Noah Harari on CRISPR, AI, and the future of humanity https://youtu.be/V66hlLruZTU?si=MdlJRiceXyWigZ0R have you ever seen a parasailing spider?  https://youtube.com/shorts/qjUAhaRdVb4?si=YMC2EVKTw2jP3CHU How India's unplanned hydropower dams and tunnels are disrupting Himalayan landscapes https://theconversation.com/how-indias-unplanned-hydropower-dams-and-tunnels-are-disrupting-himalayan-landscapes-261956 The Ganges River is drying faster than ever – here's what it means for the ... Read more The post quando perdemos a curiosidade? aranhas que voam! o risco de brincarmos de Deus appeared first on radinho de pilha.

2/4: HEADLINE: High-Profile Corruption and Genetic Manipulation: The Cases of Lieber and He Jiankui GUEST NAME: Brandon Weichert 50 WORD SUMMARY: Brandon Weichert details how the Thousand Talents Program corrupted US scientists like Harvard's Charles Lieber, who shared military-grade nanotech research with China. The discussion pivots to the dual-use threat of CRISPR, an American genetic tool used by He Jiankui to modify unborn twins, potentially causing unintended brain augmentations. Biohacked: China's Race to Control Life. Brandon J. Weichert  (Author) 1968 MAO AND LIN

TWiV explains experiments to create genetically modified chickens that are resistant to avian influenza infection, and discovery of combination antiviral therapy for HTLV-1 infection. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Creating avian influenza virus resistant chickens (Nat Comm) Antiretroviral therapy and apoptosis inhibition for HTLV-1 (Cell) HTLV-1 infection (Cleveland Clinic) Letters read on TWiV 1257 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Rich – Chagas Disease, an Endemic Disease in the United States Alan – Archive of molecular biology artifacts ends its long, strange trip at a museum Vincent – The World's Oceans Are Hurtling Toward Breaking Point Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

It's a dystopian new spin on spirituality in the digital age – and one that just might be poised to change the face of religion itself. Pastor Gene Pensiero Find audio, video, and text of hundreds of other prophecy updates at: https://calvaryhanford.com/prophecy Read along with us at https://calvaryhanford.substack.com Follow us on YouTube at https://youtube.com/calvaryhanford — […]

This week, we’re bringing you the first episode of Season 3 of the podcast ON CRISPR. Walter Isaacson — the bestselling biographer behind Musk, Einstein and Steve Jobs – and journalist Evan Ratliff (Shell Game, Mastermind, Longform) take a behind-the-scenes look at the story of Jennifer Doudna, one of the scientific pioneers behind the gene editing software, CRISPR. In this episode, Evan sits down with Walter Isaacson to discuss Doudna’s upbringing, the history of DNA’s discovery and gene editing, and Baby KJ, a CRISPR patient who represents a milestone for both researchers and patients.See omnystudio.com/listener for privacy information.

Jennifer Doudna thought she had won the race. She thought she had beaten out all scientific competitors when she and her co-author had shocked the world with their groundbreaking technology for gene editing. But turned out, the race had just gotten fiercer. Walter Isaacson sits down with Evan to talk about how one of the most cutthroat scientific competitions in biotech got started around one goal — making CRISPR work for humans, and getting the credit for it.See omnystudio.com/listener for privacy information.

Tonight, Evangelical Press Association Members David Paxton and JD Williams Present, "As in the Days of Noah – Man's Final Attempt to Play God"  Exploring the shocking scientific breakthroughs redefining life itself. Artificial wombs designed to carry children outside the mother's body, synthetic sperm and eggs engineered in laboratories, CRISPR gene editing promising “designer humanity,” and transhumanist dreams of merging man with machine. Video Version Available at https://www.lastchristian.net/Far from harmless progress, these developments echo the rebellion of Genesis 11, when mankind declared, “Let us build… let us make a name for ourselves.” Today's laboratories have become a new Tower of Babel, driven by pride, seeking to rewrite creation apart from the Creator.This show draws powerful prophetic parallels between modern technology and biblical warnings. From the “image of the beast” that speaks (Revelation 13) to the pharmakeia sorceries of Babylon (Revelation 18), the signs are clear, we are living in days Jesus foretold. “As it was in the days of Noah, so it shall be at the coming of the Son of Man.”With urgency and clarity, we expose the dangers of humanity's attempt to play God, while pointing to the only true hope, the return of Jesus Christ, the rightful Creator and Redeemer.For More Information Please Visit https://www.lastchristian.net/

In this episode of IDEA Collider, we are joined by Alex Telford, a biotech founder, writer, and thinker based in the San Francisco Bay Area. As the co-founder of Convoke Bio, Alex discusses his journey from studying biochemistry at UCL to founding a company that develops software tools for streamlining biopharmaceutical workflows.The conversation dives into the impact of AI and language models on the biotech industry, addressing inefficiencies in drug development, and exploring the potential of synthetic biology and personalized medicine. The discussion also touches on the future of drug discovery, China's role in biotech, and the challenges of understanding neuroscience and consciousness. Don't miss this insightful discussion on the future of biopharma innovation! 00:00 Welcome to Idea Collider00:04 Introducing Alex Telford01:59 Alex's Journey from UCL to Convoke Bio05:29 The Mission and Work of Convoke Bio07:57 Challenges in Pharma Decision Making14:05 The Role of AI in Pharma18:26 Knowledge Management and AI27:58 Staying Updated in the Fast-Moving AI Field30:25 AI's Impact on Industry Economics31:38 AI in Clinical Trials and Drug Development35:56 China's Role in Drug Discovery39:24 Neuroscience and AI: Blurring the Lines46:05 Future Predictions in Pharma51:20 Addressing Cognitive Bias in Pharma53:13 Concluding Thoughts and Future Directions Keep up with Alex Telford;LinkedIn: https://www.linkedin.com/in/alexander-telford/Website: atelfo.github.ioX: https://twitter.com/atelfoSubstack: atelfo.substack.com Follow Mike Rea On;Website: https://www.ideapharma.com/X: https://x.com/ideapharmaLinkedIn: https://www.linkedin.com/in/bigidea/ Listen to more fantastic podcast episodes: https://podcast.ideapharma.com/

How new genomic approaches are helping diagnose and treat our tiniest patientsWelcoming a new baby brings boundless love, joy, and the usual sleepless nights of early parenthood. But in the NICU, when a newborn is unexpectedly sick, it's the uncertainty that keep parents awake.In this episode, our investigation takes us inside the neonatal intensive care unit, where genomic tools are mapping medical mysteries in record time. You'll hear the remarkable story of “Baby KJ,” the first newborn to receive a personalized CRISPR treatment; insights from pediatric geneticist Dr. Tara Wenger on how new approaches to testing are changing care; and the story of Meredith Thomas– a mother whose fight for answers helped uncover a diagnosis that saved her daughter's life.From faster diagnoses to fairer care, join Dr. Kaylee Byers to learn how these genomic breakthroughs are redefining what's possible for newborns and their families.Resources1. World's First Patient Treated with Personalized CRISPR Gene Editing Therapy at Children's Hospital of Philadelphia- Children's Hospital of Philadelphia2. SeqFirst: Building equity access to a precise genetic diagnosis in critically ill newborns- The American Journal of Human Genetics3. Implementation of First-Line Rapid Genome Sequencing in Non–Critical Care Pediatric Wards- The Journal of Pediatrics4. Genetic Non-Discrimination Act- The Government of Canada

We discuss the sketchy "science by press release" of Colossal Biosciences and the controversies lurking in the history of its lead scientist. Have they resurrected dire wolves? No. Definitely not. If only overblown celebrity endorsed hype was the only problem…Did they make a Dire Wolf? (Spoiler: NOT EVEN REMOTELY CLOSE)George Church's explanation of Epstein tiesJames Arthur Ray - Guru of Death?Tony Robbins (more from Quora and Reddit)Peter Jackson and the MoaGeorge R. R. Martin and the Dire WolfFor a more… salacious take on this, check out the 2-part "Behind the Bastards" coverage of this topic. Part 1 and Part 2.--- on a more positive note ---What is CRISPR?Become a supporter of this podcast: https://www.spreaker.com/podcast/monstertalk--6267523/support.Some product links may be affiliated with Amazon revenue sharing.

We're fascinated by the microbiome — and for good reason. But how do we protect this invisible ecosystem that plays such a vital role in our health?From engineering live, programmable therapeutics that disarm dangerous gut pathogens to creating a global “doomsday vault” to safeguard the diversity of human gut microbes, we dive deep into the cutting-edge science shaping the future of microbiome research.Show notes1. Ronda, C., Perdue, T., Schwanz, L. et al. Precise virulence inactivation using a CRISPR-associated transposase for combating Enterobacteriaceae gut pathogens. Nat. Biomed. Eng (2025). https://doi.org/10.1038/s41551-025-01453-12. 2. Dominguez-Bello, M.G., Steiger, D., Fankhauser, M. et al. The microbiota vault initiative: safeguarding Earth's microbial heritage for future generations. Nat Commun 16, 5373 (2025). https://doi.org/10.1038/s41467-025-61008-5

Back in the 1990s, a young microbiologist in Alicante, Spain became obsessed with a strange pattern he observed in the genes of tiny organisms — a series of inexplicable clusters. And he wasn’t alone. All around the world, a network of scientists were growing curious as to what these genetic knots could be and all of their potential functions. Their curiosity would prove to be the foundation for a history altering discovery: the ability to edit our genetic code. See omnystudio.com/listener for privacy information.

¿Y si tu plato fuera un documento histórico? En este directo con JM Mulet leemos el mundo a través de la comida: del tuétano prehistórico al fast food, del garum romano al CRISPR, desmontando mitos y entendiendo por qué no “somos lo que comemos”, sino que comemos lo que somos. En una conversación ágil, divertida y muy documentada, hablamos de cómo la cultura, la religión, el comercio, la ciencia y la tecnología han cocinado lo que hoy llamamos “nuestra” cocina. ¿De verdad lo “natural” es siempre mejor? ¿Por qué el pan fue una infraestructura de poder? ¿Qué aprendió Europa del mundo árabe con el azúcar y la fritura? ¿Y qué cuenta de nosotros la comida rápida además de calorías? Qué te llevarás si ves este directo - Una historia cultural de la comida contada como nadie te la ha contado. - Mitos desmontados con evidencia (sin moralinas). - Claves para entender por qué comemos lo que comemos… y cómo podría cambiar mañana. - Preguntas afiladas para mirar tu despensa con otros ojos. Dale a “Recordatorio”, suscríbete y comparte con quien disfrute de pensar (y comer) mejor. Deja en comentarios la pregunta que te gustaría hacerle a Mulet: la leeremos en directo. JM Mulet (Denia, 1973) Licenciado en química y doctor en bioquímica y biología molecular por la Universidad de Valencia. Hizo una estancia postdoctoral de tres años en la Universidad de Basilea (Suiza). Actualmente es catedrático de bioquímica y biología molecular en el departamento de biotecnología de la Universidad Politécnica de Valencia (UPV) y dirige una línea de investigación en el Instituto de Biología Molecular y Celular de Plantas, centro mixto del CSIC y la UPV del que además es vicedirector, tratando de desarrollar plantas tolerantes a sequía o a frío, con numerosas publicaciones científicas, patentes y algún premio. En paralelo a su labor académica e investigadora desarrolla una amplia actividad como divulgador científico. Es autor de 10 libros, entre ellos Comer sin Miedo del que se han vendido más de 20.000 ejemplares y se ha publicado en varios países, y de otros títulos como Medicina sin Engaños, La Ciencia en la Sombra, Transgénicos sin miedo o de Ecologismo real. Escribe la sección “Ciencia sin Ficción” en El País Semanal y Fotogramas de ciencia en Métode. Es colaborador en varios programas de radio. Conferenciante habitual sobre temas relacionados con la alimentación o la biotecnología y su cuenta de X/twitter es una de las más seguidas de un científico en activo de habla hispana (@jmmulet). Su último libro es Comemos lo que somos. que puedes adquirir preferiblemente en tu libreria de confianza o aquí: https://amzn.to/3I9598c Síguenos en Redes Twitter: https://twitter.com/radioelrespeto Instagram: https://www.instagram.com/radioelrespeto/ Facebook: https://www.facebook.com/radioelrespeto Redes Sociales del Equipo: | Pablo Fuente | https://www.instagram.com/pablofuente/ | Nacho Sevilla | https://twitter.com/nachorsevilla | Fernando Sierra | https://twitter.com/Peeweeyo1

00:45 Attributing extreme heat events to major energy producersMajor energy producers increased the likelihood and intensity of heatwaves, according to research published in Nature. Using data from an international disaster database, a team developed a methodology to investigate how much anthropogenic climate change had influenced heatwaves. They conclude that many of these events would have been “virtually impossible” without climate change, and that nearly a quarter of the heatwaves recorded from 2000 to 2023 can be directly linked to the greenhouse-gas emissions from individual energy giants.Research Article: Juvé et al.News and Views Forum: Heatwaves linked to emissions of individual fossil-fuel and cement producersNews: Dozens of heatwaves linked to carbon emissions from specific companies10:47 Research HighlightsHow shifting coastal tides may have spurred the rise of the world's oldest civilization — plus, the liquid crystal lenses that can refocus in a flash.Research Highlight: Changing tides ushered in the world's first civilizationResearch Highlight: Liquid-crystal specs refocus with the push of a button12:40 The growing resistance to the US war on scienceScience in the United States is facing an increasing crisis, in the face of swinging cuts and President Donald Trump's ongoing attack on anything with a connection to diversity, equity and inclusion. In the face of this crisis, many researchers are fighting back — we hear about some of their efforts, and what they think about their chances of success.News Feature: Scientists take on Trump: the researchers fighting back27:28 Briefing ChatHow CRISPR-edited pancreas cells could offer new hope for those with type 1 diabetes, and what brain scans reveal about how we process colour.Nature: Hope for diabetes: CRISPR-edited cells pump out insulin in a person — and evade immune detectionNature: My blue is your blue: different people's brains process colours in the same waySubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Football Team Valuations Sexy is back - Retail What winning the Powerball Jackpot means A little 1,000,000 revision... PLUS we are now on Spotify and Amazon Music/Podcasts! Click HERE for Show Notes and Links DHUnplugged is now streaming live - with listener chat. Click on link on the right sidebar. Love the Show? Then how about a Donation? Follow John C. Dvorak on Twitter Follow Andrew Horowitz on Twitter Warm-Up - Stagflation - as payrolls drop - People in glass houses ....Stupid Politics - We are still here - which means we did not win the Powerball Jackpot - They say it will never happen - Ban on stock ownership for Congress Markets - CRISPR Chocolates? - Tech - again the driver - Sexy is back - Retail - Take in stride - on 900k less workers - ORACLE!!!!!! Powerball Jackpot - $1.8 Billion - Two winners - Texas and Missouri - Each winning ticket holder can choose either an annuitized prize of $893.5 million or a lump sum payment of $410.3 million – both before taxes. - Additionally, two lucky tickets sold in Kansas and Texas won a $2 million prize and 18 tickets sold across 13 states won $1 million. - Back to just $20 million now... - The odds of winning were 1 in 292.2 million, according to the Multi-State Lottery Association, which oversees the game. Glass Houses - Pulte - Accuses Fed's Cook and with simple accusations Trump looking to Fire ... - Close relatives of the federal official who has accused a Federal Reserve governor of improperly claiming primary residence on two properties have declared the same status on two homes in two different states, public records show. - Mark and Julie Pulte, the father and stepmother of Bill Pulte, President Donald Trump's appointee as director of the Federal Housing Finance Agency, since 2020 have claimed so-called “homestead exemptions” for residences in wealthy neighborhoods in both Michigan and Florida, according to the records. The exemption is meant to give a discount to homeowners on taxes for properties they use as their primary residence. - Local tax officials in both states told Reuters that claiming more than one home as a primary residence isn't generally allowed in their jurisdictions and could be punishable by fines or back taxes. - After Reuters contacted tax officials in Bloomfield Township, Michigan, to inquire about the dual claims, Darrin Kraatz, director of assessing, on Thursday said the township “as of today” would revoke the exemption on the Pultes' residence there. Beat Your Ass - Seems at a recent dinner- Pulte got under Scott Bessent's skin and bessent was pissed - F You - I am going to beat your ass - punch you in the F'n mouth for bad talking me to president Trump - Class act these children Chocolate Editing - Candy maker Mars said Wednesday it has partnered with biotech company Pairwise to speed up the development of more resilient cocoa using CRISPR-based gene editing technology. - CRISPR technology is a gene-editing tool that makes changes to DNA and can be used in farming. - The goal is to create cacao plants that can better withstand disease, heat and other climate-related stresses that can put global chocolate supply at risk. ---- Public Service: The main difference between cocoa and cacao: cacao is minimally processed and remains largely raw and nutrient-dense, while cocoa is made from roasted cacao beans that have been processed at high temperatures. This heat and processing affect cacao's nutrient profile and flavor, making cacao powder more bitter and richer in nutrients, and cocoa powder milder and more suitable for baking. GOOGLE for the win - Google shares popped 8% on Wednesday last week as investors celebrated what they viewed as minimal consequences from a historic defeat last year in the landmark antitrust case. - Last year, Google was found to hold an illegal monopoly in its core market of internet search. - U.S.

Earlier this year, when the world learned the news of baby KJ successfully undergoing the first personalized genetic treatment, it represented a milestone for researchers and patients. But behind this scientific feat there’s the story of the technology that made it possible, CRISPR, and one of the key pioneers behind it — Jennifer Doudna. Evan sits down with Walter Isaacson to understand how Doudna’s upbringing in Hilo, Hawaii influenced her trajectory as a gene editing scientist. And how the history of gene editing might have started with understanding DNA, but soon after, it became clear the real secret lay with its underrated sibling molecule, RNA.See omnystudio.com/listener for privacy information.

In this special episode, host Jeremy Schrand sits down with Jill Brinck, Executive Director of CancerFree KIDS, and Dr. Genevieve Kendall, a CancerFree KIDS grant recipient and pediatric cancer researcher at Baylor College of Medicine. Together, they explore the power of early-stage research funding, the challenges and breakthroughs in treating childhood cancers, and the inspiring mission behind CancerFree KIDS. Dr. Kendall shares insights into her lab's work on fusion-driven rhabdomyosarcoma and how innovative models like transgenic zebrafish are helping uncover new therapeutic targets. Whether you're a parent, a scientist, or someone passionate about making a difference, this episode offers a compelling look at how collaboration and curiosity are driving real change in pediatric oncology. Learn more - CancerFree KIDS home page Learn more about Dr Kendall's research - Kendall Lab | Nationwide Children's Hospital Learn more about CTI - CTI - CRO Specializing In Clinical Research And Consulting  02:03 Jill Brink shares her personal and professional journey that led her to become Executive Director of CancerFree KIDS.  04:02 Why funding early-stage, high-risk research is essential for pediatric cancer, highlighting the lack of profitability and federal support in this space. 05:46 Securing funding for early-stage research presents major challenges, including the need for collaboration between scientists and business leaders.  07:06 How CancerFree KIDS selects research projects, outlining the role of their Scientific Advisory Council and the grant scoring process. 09:26 Success stories driven by CancerFree KIDS funding, including early support for clinical trials and advancements in flash proton therapy. 11:22 Dr. Genevieve Kendall explains the nature of fusion-driven rhabdomyosarcoma and why its aggressive behavior and lack of targeted therapies make it difficult to treat. 13:51 How the CancerFree KIDS grant supported a new partnership and provided seed funding to test a promising research idea. 14:50 The significance of identifying HAS3 as a novel target and how it opens new possibilities for treating rhabdomyosarcoma. 16:35 Dr. Kendall describes the role of transgenic zebrafish in her research and how they help uncover therapeutic targets through comparative oncology. 19:33 Both guests share what excites them most about the future of pediatric cancer research, including innovations in CRISPR and immunotherapy. 22:32 How CancerFree KIDS measures the long-term impact of its grants, citing follow-up funding, startup companies, and FDA projects. 24:19 Jill highlights impactful partnerships and community initiatives, such as Jersey Mike's Day of Giving and the 100-Mile Challenge. 26:15 Details about the 100-Mile Challenge, including its structure and supporting events throughout September. 27:51 How CancerFree KIDS engages with families affected by cancer, ranging from support programs to events that honor children and their journeys. 29:51 The future direction of CancerFree KIDS, including expansion, collaboration, and advocacy efforts with the state of Ohio. 

Microsoft reportedly plans to begin using Anthropic's latest Claude models to power some of the Copilot features in its Office 365 apps. In a report published Tuesday, The Information said the tech giant would announce the change "in the coming weeks." Microsoft currently relies on OpenAI's tech to power the majority of AI features found inside of Word, Excel, Outlook and PowerPoint. Also, the FDA approved the biotech company eGenesis to begin human trials of pig-to-human kidney transplants. eGenesis provides pigs with CRISPR-modified genes. These genetic changes reduce the chances of organ rejection in human recipients. Learn more about your ad choices. Visit podcastchoices.com/adchoices

UC Davis scientists use CRISPR to help wheat boost soil bacteria and cut fertilizer costs for farmers.

Walter Isaacson - bestselling biographer behind Musk, Einstein and Steve Jobs - in conversation with Evan Ratliff brings you behind the scenes of The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. The story of the third great technological revolution in modern times. See omnystudio.com/listener for privacy information.

On todays show the Future Foursome talk about Google antitrust, AI developments, Starlink demand, quantum computing, biomedical advancements, autonomous vehicles, AI in sports, global warming, cybersecurity, robotics, AI in healthcare, LASIK without lasers, microplastics in blood, brain-computer interfaces, CRISPR in mosquitoes. Don't miss it!

Een nieuw Nerdland maandoverzicht! Met deze maand: Robot games! Flosdraad! Wavy Dave! Tattoos! GPT-5! Teken! Inbelmodems! Wevermieren! Garum! En veel meer... Shownotes: https://podcast.nerdland.be/nerdland-maandoverzicht-september-2025/ Gepresenteerd door Lieven Scheire met Hetty Helsmoortel, Marian Verhelst, Peter Berx, Jeroen Baert en Els Aerts. Opname, montage en mastering door Jens Paeyeneers en Els Aerts.(00:00:00) Intro (00:02:03) ROBOT OLYMPICS in Beijing (00:10:53) Iedereen wil robot olympics: ook Athene (00:12:49) Unitree R1 kost nu 6000 euro! (00:14:24) Figure robot kan wasmachine inladen (00:21:25) Neen, er is geen zwangerschapsrobot… (00:25:12) Tekenbeet kan je allergisch maken voor… vlees (00:31:00) Met Alphafold gewassen weerbaarder maken tegen bacteriën (00:36:54) Mannetje nieuwe tarantulasoort durft vrouwtje niet te benaderen (00:42:48) De inbelmodem is officieel overleden… (00:49:33) AI meets CRISPR for precise gene editing (00:54:07) Vaccin toedienen met dental floss (00:56:41) UGent doet nieuwe vaccinatietesten en zoekt vrijwilligers (01:00:04) SILICON VALLEY NEWS (01:00:22) GPT-5 stelt teleur, alweer wordt de AI crash voorspeld (01:11:41) OpenAI lanceert downloadbaar reasoning model (01:16:49) DeepSeek schakelt terug over op Nvidia chips tegen de wil van China in (01:21:38) Succesvolle 10e lancering Starship (01:24:05) X 37B gelanceerd met “quantum equipment” aan boord (01:29:00) We weten eindelijk welke vis er in garum zit (01:31:51) Krabrobot zwaait naar vioolkrabben (01:38:02) Artemis II crew doet uitgebreide testen met Orion (01:43:03) Krachtmeting van wevermieren (01:49:24) TRAPPIST – 1d is minder aardachtig dan gedacht (01:52:25) Dieet van enkel mieren is 12 keer afzonderlijk ontstaan in de evolutie (01:59:05) 2500 jaar oude tattoos gereconstrueerd, en die zijn verbazend mooi (02:04:01) Studie van vlinderstichting offline na doodsbedreiging (02:06:23) De patat is een dochter van de tomaat (02:07:51) Belgische tak van palingmaffia opgerold (02:11:13) De stormvogel poept alleen in de lucht, en niemand weet waarom (02:13:18) Aankondigingen (02:19:57) Sponsor SIEMENS

Gene therapy is no longer reserved for rare diseases or billionaire tech founders. In this episode, I sit down with Jay Spall, senior executive at MiniCircle, to discuss how gene therapy has entered a new era—one where optimizing your health, building muscle, and extending your lifespan can be done safely, affordably, and effectively.Jay shares how MiniCircle's first breakthrough product, Follistatin, uses plasmid-based delivery to boost muscle growth, reduce fat, and improve metabolic health—all from a single injection. We break down what gene therapy really is, how it compares to CRISPR, how long the effects last, and what to expect in terms of results and safety. Plus, Jay offers a look into the company's future therapies and his powerful personal journey from chronic illness to radical transformation.We cover the science, the stories, and the surprising benefits you might not expect.Interested in receiving Follistatin gene therapy? Contact our clinic, Chara Health, at 818-356-8232 or email info@chara-health.comKey Takeaways:Introduction (00:00)Jay's personal health journey and introduction to gene therapy (02:24)Minicircle's gene therapy technology and initial success (08:29)Follistatin's benefits and real-world applications (11:14)Clinical study results and broader health benefits (13:52)Muscle gain, fat loss, and strength benefits (19:08)How long does Follistatin's benefit last (22:48)How involved is Follistatin treatment (28:01)Follistatin side effects (33:08)Challenges and future directions of gene therapy (42:24)Additional Resources:If you are interested in receiving Follistatin gene therapy, please contact our clinic Chara Health at 818-356-8232, or email info@chara-health.com.✨ Connect with Jay SpallWebsite: https://minicircle.io/our-therapies/follistatin/Instagram: https://www.instagram.com/minicircledna/—✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

Why billionaire tech mogul Peter Thiel’s lecture series on the Antichrist is a sign that biblical end-time prophecies are stage-setting for the Rapture. Pastor Gene Pensiero Find audio, video, and text of hundreds of other prophecy updates at: https://calvaryhanford.com/prophecy Read along with us at https://calvaryhanford.substack.com Follow us on YouTube at https://youtube.com/calvaryhanford — The signs of […]

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: CRISPR modified cell transplant for type 1, risk of T1D if parent has a different type of diabetes, Metformin and the brain, oral GLP-1, and more! Find out more about Moms' Night Out  Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom   Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links: Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX A 42-year-old man who has lived most of his life with type 1 diabetes has become the first human to receive a transplant of genetically modified insulin-producing cells. This marks the first pancreatic cell transplant in a human to sidestep the need for immunosuppressant drugs. “This is the most exciting moment of my scientific career,” says cell biologist Per-Ola Carlsson of Uppsala University in Sweden, who helped develop the procedure. The new treatment, he says, “opens the future possibility of treating not only diabetes but other autoimmune diseases.” This procedure uses the gene editing technique, CRISPR, to discourage the auto immune attack on the donor cells. Before the transplant, the participant had no measurable naturally produced insulin and was receiving daily doses of the hormone. But within four to 12 weeks following the transplant, his levels rose slightly on their own after meals—showing that the new beta cells were releasing some insulin in response to glucose. even though the new study is promising, it involved just one participant and is therefore preliminary. And longer-term monitoring is needed to confirm the therapy's safety before it can be offered to more people. She also notes that the injected cells produced only 7 percent of the insulin needed for a person to be fully independent of additional medication. The researchers supplied the recipient with insulin doses to maintain healthy blood sugar levels. While Herold thinks it's still too early to consider this approach for a cure, “these options are now here to change the disease in ways that have never been possible before,” he says. “There's tremendous hope.” https://www.scientificamerican.com/article/type-1-diabetes-patients-insulin-production-restored-with-new-cell/ XX   This one is interesting… a recent study shows that children of mothers with gestational diabetes or fathers with type 2 diabetes have higher chances of developing type 1 diabetes than kids whose parents do not have any type of diabetes. Specifically, the study found that children whose mothers had gestational diabetes during pregnancy were 94% more likely to develop type 1 diabetes compared to children of mothers without diabetes. Similarly, having a father with type 2 diabetes was linked to a 77% higher risk. The study also suggests a possible link between maternal type 2 diabetes and type 1 diabetes in children, although more data are needed to confirm whether the risk is real.   "What is interesting is that type 1 diabetes is a disease of lack of the hormone insulin while gestational diabetes and type 2 diabetes stem mostly from the body's resistance to the hormone. What may be happening is that genes, environments and behaviors that create insulin resistance may also, in some cases, trigger the immune reactions that lead to type 1 diabetes," adds Dr. Dasgupta. A 2019 meta-analysis by researchers at Soochow University in China found that gestational diabetes was linked to a 66% higher risk of type 1 diabetes in children. This new study, which includes more than twice as many studies, offers a robust synthesis of current evidence and shows the risk is even greater than previously estimated. It is also the first meta-analysis to examine the link between paternal type 2 diabetes and type 1 diabetes in offspring. "Several mechanisms may be at play. Families often share lifestyle and eating habits, which can raise the likelihood that children will be affected. But beyond that, high blood sugar levels may also cause biological changes in parents that could increase their children's risk of developing type 1 diabetes," explains Laura Rendon, co-first author of the study, who completed an MSc in experimental medicine at The Institute and, as someone living with type 1 diabetes herself, finds deep personal meaning in conducting this research. For instance, the authors suggest that high blood sugar during pregnancy may stress the fetus's insulin-producing beta cells, reducing their number at birth or making them more vulnerable to damage later in life. It may also trigger epigenetic changes—modifications to proteins and molecules attached to DNA—that increase the risk. Likewise, high blood sugar in fathers with type 2 diabetes may cause epigenetic changes in their sperm, potentially influencing their child's risk of developing type 1 diabetes. https://medicalxpress.com/news/2025-08-diabetes-children-linked-parents.html XX Can a CGM help you lose weight? The company Signos is banking on it – the just got FDA approval for their system, which uses the over the counter Dexcom Stelo. The claim here is that the system will help track how food choices, activity, stress and sleep can all affect metabolism. Signos also works in partnership with the digital nutrition counseling startup Nourish. It currently offers a quarterly subscription plan, including six CGM sensors, for $139 per month. And they tell you don't take any medical actions based on the app's output without consulting a physician. https://www.fiercebiotech.com/medtech/fda-clears-signos-over-counter-cgm-powered-weight-loss-app XX Good news for T1D1, a free mobile app that helps people calculate insulin doses, track daily data, and share insights with healthcare providers. After being pulled off the market with similar apps a few years ago, it's now back and FDA approved. Drew Mendelow created the app after his diagnosis at age 13. He came on the show last year and I'll link his story up in the show notes. Diabetes Center Berne provided the initial funding to support the T1D1 efforts to redesign the app per FDA standards.  Comerge AG , the registered manufacturer, enlisted a team of software engineers, regulatory experts, and design professionals to ensure T1D1 was FDA-ready. Dexcom graciously conducted the Human Factors study to ensure safety and accuracy.  ​ ​T1D1 is now FDA-cleared as a Class II medical device and is the first over-the-counter insulin calculator cleared for individuals aged 2 and older. T1D1 is expected to be live in the AppStore and Google Play Store by October 2025. https://diabetes-connections.com/the-fda-took-down-this-teens-free-bolus-calculator-he-needs-your-help-to-bring-it-back/ XX Metformin has been the standard treatment for type 2 diabetes for more than six decades, yet scientists still do not fully understand how it works. A team from Baylor College of Medicine, working with international collaborators, has now identified an unexpected factor in its effectiveness: the brain. Their findings reveal a brain pathway involved in metformin's glucose-lowering action, pointing to new strategies for treating diabetes with greater precision. The study was published in Science Advances. The researchers concentrated on a small protein called Rap1, located in a region of the brain known as the ventromedial hypothalamus (VMH). They discovered that metformin's ability to lower blood sugar at clinically relevant doses depends on suppressing Rap1 activity in this brain area.   “This discovery changes how we think about metformin,” Fukuda said. “It's not just working in the liver or the gut, it's also acting in the brain. We found that while the liver and intestines need high concentrations of the drug to respond, the brain reacts to much lower levels.”     https://scitechdaily.com/after-60-years-scientists-uncover-hidden-brain-pathway-behind-diabetes-drug-metformin/   XX Looks like GLP-1 pills are moving ahead. Lilly says it's version helped overweight adults with type 2 lose 10% of their body weights and lower A1C. Just two weeks ago, we were talking about how the same drug in people without diabetes had less than the stellar expected results. Orforglipron is a small-molecule pill that is easier to manufacture and package than wildly popular injectable drugs for obesity, such as Lilly's Zepbound and Novo Nordisk's NOVOb.CO rival treatment Wegovy, which are peptide mimics of the appetite-controlling GLP-1 hormone. In the 72-week study of more than 1,600 overweight or obese adults with type 2 diabetes, those who received the 36-milligram highest dose of orforglipron on average shed 10.5% of their weight, or about 23 pounds (10.43 kg), versus 2.2% for those who received a placebo, achieving the main goal of the trial. Patients on the lowest 6 mg dose of the Lilly drug lost 5.5% of their weight. https://www.usatoday.com/story/news/health/2025/08/26/lilly-glp-1-pill-weight-loss/85830686007/ XX     An intervention that combined a low-calorie Mediterranean diet and exercise led to less diabetes incidence in older adults. Men had a greater diabetes risk reduction with the intervention than women. The study was based in Spain, and the diet may not be as easy to adhere to in the U.S. Among nearly 5,000 adults with metabolic syndrome and overweight or obesity in the PREDIMED-Plus trial, those who followed this intervention had a 31% lower risk for type 2 diabetes over 6 years relative to those who received only ad libitum Mediterranean diet advice (aHR 0.69, 95% CI 0.59-0.82). the Mediterranean diet focuses on high intake of plant-based foods, moderate consumption of fish, poultry, and dairy with optional red wine, and low intake of red meats, sweets, and sugar-sweetened beverages. Common foods featured in the diet include extra-virgin olive oil, fruits, vegetables, legumes, nuts, and whole grains. However, Sharon Herring, MD, MPH, and Gina Tripicchio, PhD, MSEd, both of Temple University in Philadelphia, pointed out that this study was conducted solely in Spain, and sticking to this type of diet may be more challenging in countries like the U.S.   "Participants in the study received extra-virgin olive oil to support adherence and retention; in the United States, prices of extra-virgin olive oil have nearly doubled since 2021 due to a combination of factors including climate change, rising production costs, supply chain disruptions, and now tariffs," they noted in an accompanying editorial. "[T]he large number of dietitian contacts during the study may prove difficult to scale broadly in the United States given challenges with health care access and reimbursement for prevention services."         https://www.medpagetoday.com/primarycare/diabetes/117151 XX A group of Canadian researchers has identified an unexpected way to lower blood sugar and protect the liver: by capturing a little-known fuel produced by gut bacteria before it enters the body and causes harm. The findings, published in Cell Metabolism, could open the door to new therapies to treat metabolic diseases like type 2 diabetes and fatty liver disease. Scientists from McMaster University, Université Laval, and the University of Ottawa discovered that a molecule generated by gut microbes can cross into the bloodstream, where it drives the liver to overproduce glucose and fat. By designing a method to trap this molecule in the gut before it reaches circulation, they achieved striking improvements in blood sugar regulation and fatty liver disease in obese mice. https://scitechdaily.com/scientists-discover-a-surprising-new-way-to-fight-diabetes/ XX Dexcom, which specializes in technology for glucose biosensing, will lay off 350 workers, with nearly 200 of them in San Diego, according to the San Diego Union Tribune. The bulk of the local jobs being lost are focused on Dexcom operations and manufacturing. The Dexcom development follows cutbacks to Verily, a life sciences company that is a subsidiary of Alphabet, Google's corporate parent. Verily's work included a project with Dexcom on wearable glucose sensors. CEO Stephen Gillett, in a memo obtained by the publication, said there will be “workforce reductions across Verily.” A representative for Verily confirmed to Business Insider that “we have made the difficult decision to discontinue manufacturing medical devices and will no longer be supporting them going forward.” https://timesofsandiego.com/business/2025/08/27/report-life-sciences-firm-dexcom-lay-off-200-san-diego-workers/ XX Front office changes at Insulet. Eric Benjamin, former chief product and customer experience officer, will take the role of chief operating officer, effective immediately. Manoj Raghunandanan Mu-NOHJ Rug-a-nun-da-nun to the position of chief growth officer, leading Insulet's new growth organization. The appointments are some of CEO Ashley McEvoy's first changes since she was hired in April. The appointments come after McEvoy outlined four priorities for Insulet on an August earnings call:   enhancing the company's commercial capabilities, building Insulet's brand and direct-to-consumer capabilities, driving growth outside of the U.S. and accelerating the pace of innovation. https://www.medtechdive.com/news/insulet-eric-benjamin-manoj-raghunandanan-appointments/758668/ XX   XX Want to highlight The Children's Diabetes Foundation in Colorado – they held a medal ceremony for patients of the Barbara Davis Center who've lived with Type 1 diabetes for 50 years or more. There were 87 medal recipients in the ceremony including Dana Davis, Executive Director of the Children's Diabetes Foundation and the daughter of the founders of the Barbara Davis Center. Davis shared: "When you got Type1 diabetes in the 70s, they thought you shouldn't have children. They thought you weren't going to live past 30 or 40. It was definitely very different," Davis said.   https://www.cbsnews.com/colorado/news/barbara-davis-center-celebrates-colorado-type-1-diabetes-patients-milestone/

We love to hear from our listeners. Send us a message.In this episode of Cell & Gene Podcast episode, Host Erin Harris talks to Stanford School of Medicine Ph.D. student, Yuanhao Qu, about his work developing CRISPR-GPT, an AI-driven multi-agent system designed to automate genetic experimental design and data analysis, making CRISPR experiments more efficient and accessible, even for non-experts. Qu explains how CRISPR-GPT addresses key challenges such as guide design, delivery methods, off-target prediction, and protocol generation, and shares how collaborations with Princeton helped shape the tool's architecture and evaluation. Qu also discusses Biomni, a general-purpose biomedical AI agent aimed at supporting a broad range of life science applications, and how the two systems complement each other as building blocks toward an "AI scientist" capable of accelerating discovery across biomedicine. Qu emphasizes the importance of rigorous evaluation, productivity gains, and ethical guardrails to ensure these tools are powerful yet safe for the future of biomedical research.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect with me on LinkedIn

El plástico usado en botellas y envases (PET) tarda siglos en degradarse y contamina mares, ríos y suelos. Pero, ¿y si unas bacterias pudieran comérselo? Manuel Ferrer, nuestro invitado en Hablando con Científicos, es uno de los investigadores del CSIC que, junto a colegas del Barcelona Supercomputing Center, ha logrado enseñar a la bacteria E. coli, muy común en los laboratorios, a degradar plástico. La clave es GenRewire, una técnica que combina inteligencia artificial, supercomputadores y CRISPR, el famoso “corta y pega” genético. En lugar de añadir genes de otras especies, los científicos reprogramaron las propias proteínas de E. coli para que aprendiera a romper el PET. ¿El resultado? La bacteria consiguió deshacer nanopartículas de plástico y transformarlas en compuestos que incluso pueden reutilizarse. Por ahora es solo una prueba de concepto, pero abre un camino fascinante: crear microbios “recicladores” capaces de convertir montañas de residuos en nuevos recursos.

El plástico usado en botellas y envases (PET) tarda siglos en degradarse y contamina mares, ríos y suelos. Pero, ¿y si unas bacterias pudieran comérselo? Manuel Ferrer, nuestro invitado en Hablando con Científicos, es uno de los investigadores del CSIC que, junto a colegas del Barcelona Supercomputing Center, ha logrado enseñar a la bacteria E. coli, muy común en los laboratorios, a degradar plástico. La clave es GenRewire, una técnica que combina inteligencia artificial, supercomputadores y CRISPR, el famoso “corta y pega” genético. En lugar de añadir genes de otras especies, los científicos reprogramaron las propias proteínas de E. coli para que aprendiera a romper el PET. ¿El resultado? La bacteria consiguió deshacer nanopartículas de plástico y transformarlas en compuestos que incluso pueden reutilizarse. Por ahora es solo una prueba de concepto, pero abre un camino fascinante: crear microbios “recicladores” capaces de convertir montañas de residuos en nuevos recursos.

On this episode of The Agronomists, host Lyndsey Smith is joined by guests Dr. Liping Wang from the University of Guelph and Chris Manchur from the Canola Council of Canada to discuss RNAi technology and CRISPR technology, how they work, and how these plant breeding techniques could impact cropping decisions in the future. From what... Read More

If DNA is just a string of letters, could AI learn to read it … or even write it? Bioengineering researcher Eric Nguyen reveals how AI has upended the rules of biology, potentially creating a future where disease is cured with personalized medicine, extinct species are resurrected (Jurassic Park, anyone?) and microbes designed for Mars make interplanetary life possible. Learn more about how the world's first AI-designed CRISPR model successfully edited genes — and what it means for our understanding of life itself.For a chance to give your own TED Talk, fill out the Idea Search Application: ted.com/ideasearch.Interested in learning more about upcoming TED events? Follow these links:TEDNext: ted.com/futureyouTEDSports: ted.com/sportsTEDAI Vienna: ted.com/ai-viennaTEDAI San Francisco: ted.com/ai-sf Hosted on Acast. See acast.com/privacy for more information.

For UC Berkeley's Jennifer Doudna, the revolutionary discovery of CRISPR-Cas9 gene editing began 15 years ago with a meeting at the campus's Free Speech Movement Cafe. “This is a quintessential story about Berkeley,” begins Doudna, a professor of molecular and cell biology and of chemistry, in a lecture she gave on campus in April. “The research that I'll talk about today wouldn't have happened … if I had been working anywhere else. And that's because we have a really collaborative environment on our campus.”At the cafe, Doudna listened while a Berkeley colleague described a possible adaptive immune system in bacteria that helps them fight off viral infection. Doudna's lab went on to research the molecules involved, discovering a pathway that allows bacteria to "learn" about viruses, store the information and use it for protection.The scientists realized this same system could be used to trigger DNA repair in plant, animal and human cells, effectively allowing them to "rewrite the code of life." The seminal paper on CRISPR was published in 2012 by Doudna and her key collaborator, French microbiologist Emmanuelle Charpentier. The pair went on to win the Nobel Prize in Chemistry in 2020.In this Berkeley Talks episode, Doudna discusses how CRISPR can be used to correct disease-causing genetic mutations, the impact that it's already having on people's lives and where she sees the technology going in the future. “We're in an era of programmable genome editing,” she says. “It's really exciting to see all the possible applications of this. We know that it can be safe and effective to treat and even to potentially cure human disease, and we need to continue to advance the technology so that it can be deployed more widely.”Not only will that require continual activity on the science and technology front, she adds, but also in developing appropriate guidelines and regulations to ensure that CRISPR's applications move forward responsibly. Doudna's talk took place on April 4 as part of Brilliance of Berkeley, a course offered every spring by the College of Letters and Science that celebrates the campus's exceptional faculty and their accomplishments. Each week, students listen to two guest lectures by top Berkeley scholars from an array of fields, followed by a Q&A. Watch the video on the Brilliance of Berkeley YouTube page. Listen to the episode and read the transcript on UC Berkeley News (news.berkeley.edu/podcasts/berkeley-talks).Music by HoliznaCC0.Photo by Glenn Ramit/IGI. Hosted on Acast. See acast.com/privacy for more information.

Joined by the amazing Heidi (Unfiltered Rise) to discuss the tangled web of CRISPR and bio-engineered "recreational" drugs. We dive deep into the co-opting of nature, ancient rituals, and spiritual attacks.  She shares a personal story of a loved one who suffered injury from one of these substances. What are the long-term health consequences? Are government-approved grow facilities regulated? Do substance abuse facilities take patients who suffer harmful effects from these altered natural substances? We discuss cognitive behavioral therapy and much more! Follow Heidi at www.unfilteredrisepodcast.com IG @unfilteredrise_podcast  X @UnfilteredRise On Patreon and Spotify   #CRISPR #co-opting #recreationaldrugs #healthconsequences #regulation #governance #safety

The fuss over Sydney Sweeney's jeans/genes ad, and there are those who accused her of "normalizing eugenics," misses an important point: we are already doing another round of eugenics. It's just that this round is about the Haves having access to surrogates, IVF, CRISPR, and other genetic assistance while the Have Nots have plummeting fertility rates and no longterm care options when they have children with health problems. Jessa and Nico talk about the history of eugenics, why it was a leftist cause for so long, and what a baby with a $5 million miracle cure says about the future of humanity. Shownotes and references: http://theculturewedeserve.substack.com

[01:00:44] EU Push for WarOpening monologue frames EU leaders' Oval Office visit as another step toward World War III, warning of elites driving conflict. [01:02:13] Chemo Costs & CorruptionKansas woman forced to sell baked goods for $10,000/month chemo illustrates Big Pharma greed and insurance industry corruption, with added discussion of chemo's brain damage. [01:20:33] Soros & Ukraine RevolutionsClips of George Soros admitting to funding Ukraine's revolution reinforce claims of Western-engineered regime change and manufactured conflict. [01:23:02] COVID Propaganda MachineActors and government PSAs compared to “I play a doctor on TV,” exposing taxpayer-funded psy-ops that pushed vaccines and lockdowns. [01:27:00] NATO & Endless WarsCriticism of NATO as an entangling alliance meant to drag the U.S. into European wars, with sanctions framed as acts of war. [01:42:00] Culture Wars: Tradwives & FuentesAnalysis of “tradwife” influencers like Lauren Southern and Nick Fuentes, accusing them of cosplaying tradition and discouraging real families, seen as controlled opposition undermining Western civilization. [02:25:03] Milo & the Right-Wing CircusDiscussion of Milo Yiannopoulos as an unstable provocateur, linked to Alex Jones, with comparisons to Laura Loomer; highlights the grifter culture. [02:25:44] AI as Modern IdolatryHealth Impact article sparks a segment framing AI as today's “talking idols,” reflecting human emptiness rather than true intelligence. [02:45:30] CRISPR & AI GeneticsConcerns raised that CRISPR gene editing is more like a chainsaw than a scalpel, with elites now turning to AI to “clean up” dangerous genetic manipulation. [02:49:19] De-Banking & StablecoinsDiscussion of Bank of America walking back “debanking” rules against religious groups, but warning that stablecoins are a Trojan horse for CBDCs and government financial control. [03:11:01] Trump Tariffs & Food CostsNew tariffs on Brazil, Switzerland, and Mexico predicted to raise prices on coffee, chocolate, olive oil, and groceries. Large corporations can absorb costs temporarily, but small businesses and consumers will feel the squeeze. [03:29:48] Israeli Official & Sex CrimesCoverage of an Israeli official caught in a Nevada sex crime sting but quietly returned to Israel, sparking discussion of influence, Epstein networks, and government protection of predators. [03:44:05] Pornography, AI & Spiritual WarAnalysis of how pornography addiction undermines churches, worsened by AI chatbots and virtual companions that manipulate users — framed as a spiritual battle for minds and families. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.

[01:00:44] EU Push for WarOpening monologue frames EU leaders' Oval Office visit as another step toward World War III, warning of elites driving conflict. [01:02:13] Chemo Costs & CorruptionKansas woman forced to sell baked goods for $10,000/month chemo illustrates Big Pharma greed and insurance industry corruption, with added discussion of chemo's brain damage. [01:20:33] Soros & Ukraine RevolutionsClips of George Soros admitting to funding Ukraine's revolution reinforce claims of Western-engineered regime change and manufactured conflict. [01:23:02] COVID Propaganda MachineActors and government PSAs compared to “I play a doctor on TV,” exposing taxpayer-funded psy-ops that pushed vaccines and lockdowns. [01:27:00] NATO & Endless WarsCriticism of NATO as an entangling alliance meant to drag the U.S. into European wars, with sanctions framed as acts of war. [01:42:00] Culture Wars: Tradwives & FuentesAnalysis of “tradwife” influencers like Lauren Southern and Nick Fuentes, accusing them of cosplaying tradition and discouraging real families, seen as controlled opposition undermining Western civilization. [02:25:03] Milo & the Right-Wing CircusDiscussion of Milo Yiannopoulos as an unstable provocateur, linked to Alex Jones, with comparisons to Laura Loomer; highlights the grifter culture. [02:25:44] AI as Modern IdolatryHealth Impact article sparks a segment framing AI as today's “talking idols,” reflecting human emptiness rather than true intelligence. [02:45:30] CRISPR & AI GeneticsConcerns raised that CRISPR gene editing is more like a chainsaw than a scalpel, with elites now turning to AI to “clean up” dangerous genetic manipulation. [02:49:19] De-Banking & StablecoinsDiscussion of Bank of America walking back “debanking” rules against religious groups, but warning that stablecoins are a Trojan horse for CBDCs and government financial control. [03:11:01] Trump Tariffs & Food CostsNew tariffs on Brazil, Switzerland, and Mexico predicted to raise prices on coffee, chocolate, olive oil, and groceries. Large corporations can absorb costs temporarily, but small businesses and consumers will feel the squeeze. [03:29:48] Israeli Official & Sex CrimesCoverage of an Israeli official caught in a Nevada sex crime sting but quietly returned to Israel, sparking discussion of influence, Epstein networks, and government protection of predators. [03:44:05] Pornography, AI & Spiritual WarAnalysis of how pornography addiction undermines churches, worsened by AI chatbots and virtual companions that manipulate users — framed as a spiritual battle for minds and families. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.

My guest is Dr. Sergiu Pașca, MD, professor of psychiatry and behavioral sciences at Stanford University. We discuss the biology and genetics of autism, why autism diagnoses are increasing and recent progress in using stem cells to understand and treat profound autism and other brain disorders. Dr. Pașca explains “organoids and assembloids”—human stem cell–derived tools he pioneered to study, treat and cure complex brain diseases. We also discuss ethical and safety issues with using gene editing and stem cells in humans. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Helix: https://helixsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00) Sergiu Pașca (02:08) Autism Spectrum Disorder, Incidence, Genetics (07:16) Is Autism More Common in Males? (09:35) Sponsors: David & Helix Sleep (11:56) Eye Contact in Babies, Fever; Proposed Causes of Autism; Genes (18:48) Genetic or Idiopathic Autism Diagnoses, Timothy Syndrome (21:37) Rise in Autism Diagnoses (26:46) Cause, Correlation & Neurological Disease; Schizophrenia, Do Vaccines Cause Autism? (31:34) Global Increase in Autism; Gene Therapy, CRISPR, Follistatin (41:05) Sponsors: AG1 & BetterHelp (43:41) Stem Cells, Ethics, Yamanaka Factors, Human Stem Cell Models (52:03) Umbilical Stem Cells; Stem Cell Injections & Dangers, Autistic Kids (59:30) Organoids, Modeling Brain Development, Intrinsic Development Timer (1:12:22) Assembloids, Brain Cell Migration & Circuit Formation, Self-Organization (1:21:22) Four-Part Assembloid, Sensory Assembloid, Pain Conditions (1:25:45) Sponsor: Function (1:27:33) Future Medical Therapies, Cell Banking, Immortalize Tissues, Rejuvenate Cells (1:34:56) Assembloids & Ethics, Importance of Nomenclature, Science Collaboration & Self-Correction (1:45:38) Cell Transplantation & Ethics, Timing (1:55:05) Genetic Testing for Parents, Genetic Penetrance (2:02:36) Assembloids, Timothy Syndrome, Epilepsy, Schizophrenia, Dystonia (2:14:30) Scientific Career, Walking, Art, Medical School (2:20:44) Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

About this episode:  Sickle cell disease affects an estimated 100,000 people in the United States. Recent advancements in gene therapies and medicines like hydroxyurea are diminishing extreme pain, reducing strokes, and extending survival times for those afflicted by the disease. In this episode: leading sickle cell disease expert Dr. Mark Gladwin explains how revolutionary new treatments work and discusses the challenges to access to life-saving care. Guest: Dr. Mark Gladwin is a physician-scientist and the Dean of the University of Maryland School of Medicine and Vice President for Medical Affairs at the University of Maryland, Baltimore. His research focuses include sickle cell disease and hypertension. Host: Dr. Josh Sharfstein is vice dean for public health practice and community engagement at the Johns Hopkins Bloomberg School of Public Health, a faculty member in health policy, a pediatrician, and former secretary of Maryland's Health Department. Show links and related content: New sickle cell gene therapies are a breakthrough, but solving how to pay their high prices is a struggle—CNBC Gene Therapy: What You Need to Know—Sickle Cell Disease Association of American No More Pain: Breakthrough Sickle Cell Treatment from Johns Hopkins Offers Curative Potential—Johns Hopkins School of Medicine Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌JohnsHopkinsSPH on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

What happens when creating a child becomes a consumer choice? In this provocative episode of Brave New Us, research associate at the Heritage Foundation Emma Waters joins host Samantha Stephenson to break down the rising trend of embryo screening, designer genetics, and artificial wombs. From Elon Musk's child-maxxing to CRISPR enhancements and Build-a-Baby startups like Nucleus Genomics and Orchid, we explore how reproductive technologies are reshaping what it means to become a parent—and what's at stake for the children created through these tools.If you've ever asked yourself: • Is embryo selection a form of modern eugenics? • Can we separate desire from design in the future of family building? • Are children becoming products instead of persons? • What's the difference between healing and enhancement in genetic medicine?Topics Covered:Why "have healthy babies" is a deceptive marketing sloganThe ethics of picking embryos based on IQ, personality, or sexThe rise of child-maxxing among elites like Elon MuskWhy "designer babies" deepen inequality and threaten parent-child loveWhat three-parent embryos and artificial gametes mean for the future of familyThe philosophy behind eugenics—and why it's rebranded, not goneWhen CRISPR gene editing might cross the line from healing to hubrisWhy strong families—not just birthrates—should be the goal of pronatalismMentioned in the EpisodeEmma Waters' work on pronatalism and reproductive ethicsConnect with Emma on X (Twitter)New Atlantis article: Stop Hacking HumansPublic Discourse article: The Pronatalism and Silicon ValleyLeave a Review + Share the Show If this conversation made you think differently about the future of family, science, and ethics, please:Rate and review Brave New Us on Apple Podcasts or SpotifyShare this episode with a friend or on social mediaKeep the conversation going at bravenewus.substack.com

A Chinese scientist, He Jiankui, made a shocking announcement to the world in 2018: He had secretly engineered the birth of the first gene-edited babies. The birth of the twins was seen as reckless and unethical by the scientific community. That's because, among other things, the CRISPR gene-editing technique Jiankui used was so new. NPR science correspondent Rob Stein has been following the controversial world of gene-editing and human reproduction, including some companies' recent quests to push gene-editing technology forward.Read more of Rob Stein's reporting on the topic here.Interested in more science news? Let us know at shortwave@npr.org. Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy