Podcasts about CRISPR

My fellow pro-growth/progress/abundance Up Wingers,Once-science-fiction advancements like AI, gene editing, and advanced biotechnology have finally arrived, and they're here to stay. These technologies have seemingly set us on a course towards a brand new future for humanity, one we can hardly even picture today. But progress doesn't happen overnight, and it isn't the result of any one breakthrough.As Jamie Metzl explains in his new book, Superconvergence: How the Genetics, Biotech, and AI Revolutions will Transform our Lives, Work, and World, tech innovations work alongside and because of one another, bringing about the future right under our noses.Today on Faster, Please! — The Podcast, I chat with Metzl about how humans have been radically reshaping the world around them since their very beginning, and what the latest and most disruptive technologies mean for the not-too-distant future.Metzl is a senior fellow of the Atlantic Council and a faculty member of NextMed Health. He has previously held a series of positions in the US government, and was appointed to the World Health Organization's advisory committee on human genome editing in 2019. He is the author of several books, including two sci-fi thrillers and his international bestseller, Hacking Darwin.In This Episode* Unstoppable and unpredictable (1:54)* Normalizing the extraordinary (9:46)* Engineering intelligence (13:53)* Distrust of disruption (19:44)* Risk tolerance (24:08)* What is a “newnimal”? (13:11)* Inspired by curiosity (33:42)Below is a lightly edited transcript of our conversation. Unstoppable and unpredictable (1:54)The name of the game for all of this . . . is to ask “What are the things that we can do to increase the odds of a more positive story and decrease the odds of a more negative story?”Pethokoukis: Are you telling a story of unstoppable technological momentum or are you telling a story kind of like A Christmas Carol, of a future that could be if we do X, Y, and Z, but no guarantees?Metzl: The future of technological progress is like the past: It is unstoppable, but that doesn't mean it's predetermined. The path that we have gone over the last 12,000 years, from the domestication of crops to building our civilizations, languages, industrialization — it's a bad metaphor now, but — this train is accelerating. It's moving faster and faster, so that's not up for grabs. It is not up for grabs whether we are going to have the capacities to engineer novel intelligence and re-engineer life — we are doing both of those things now in the early days.What is up for grabs is how these revolutions will play out, and there are better and worse scenarios that we can imagine. The name of the game for all of this, the reason why I do the work that I do, why I write the books that I write, is to ask “What are the things that we can do to increase the odds of a more positive story and decrease the odds of a more negative story?”Progress has been sort of unstoppable for all that time, though, of course, fits and starts and periods of stagnation —— But when you look back at those fits and starts — the size of the Black Plague or World War II, or wiping out Berlin, and Dresden, and Tokyo, and Hiroshima, and Nagasaki — in spite of all of those things, it's one-directional. Our technologies have gotten more powerful. We've developed more capacities, greater ability to manipulate the world around us, so there will be fits and starts but, as I said, this train is moving. That's why these conversations are so important, because there's so much that we can, and I believe must, do now.There's a widely held opinion that progress over the past 50 years has been slower than people might have expected in the late 1960s, but we seem to have some technologies now for which the momentum seems pretty unstoppable.Of course, a lot of people thought, after ChatGPT came out, that superintelligence would happen within six months. That didn't happen. After CRISPR arrived, I'm sure there were lots of people who expected miracle cures right away.What makes you think that these technologies will look a lot different, and our world will look a lot different than they do right now by decade's end?They certainly will look a lot different, but there's also a lot of hype around these technologies. You use the word “superintelligence,” which is probably a good word. I don't like the words “artificial intelligence,” and I have a six-letter framing for what I believe about AGI — artificial general intelligence — and that is: AGI is BS. We have no idea what human intelligence is, if we define our own intelligence so narrowly that it's just this very narrow form of thinking and then we say, “Wow, we have these machines that are mining the entirety of digitized human cultural history, and wow, they're so brilliant, they can write poems — poems in languages that our ancestors have invented based on the work of humans.” So we humans need to be very careful not to belittle ourselves.But we're already seeing, across the board, if you say, “Is CRISPR on its own going to fundamentally transform all of life?” The answer to that is absolutely no. My last book was about genetic engineering. If genetic engineering is a pie, genome editing is a slice and CRISPR is just a tiny little sliver of that slice. But the reason why my new book is called Superconvergence, the entire thesis is that all of these technologies inspire, and influence, and are embedded in each other. We had the agricultural revolution 12,000 years ago, as I mentioned. That's what led to these other innovations like civilization, like writing, and then the ancient writing codes are the foundation of computer codes which underpin our machine learning and AI systems that are allowing us to unlock secrets of the natural world.People are imagining that AI equals ChatGPT, but that's really not the case (AI equals ChatGPT like electricity equals the power station). The story of AI is empowering us to do all of these other things. As a general-purpose technology, already AI is developing the capacity to help us just do basic things faster. Computer coding is the archetypal example of that. Over the last couple of years, the speed of coding has improved by about 50 percent for the most advanced human coders, and as we code, our coding algorithms are learning about the process of coding. We're just laying a foundation for all of these other things.That's what I call “boring AI.” People are imagining exciting AI, like there's a magic AI button and you just press it and AI cures cancer. That's not how it's going to work. Boring AI is going to be embedded in human resource management. It's going to be embedded just giving us a lot of capabilities to do things better, faster than we've done them before. It doesn't mean that AIs are going to replace us. There are a lot of things that humans do that machines can just do better than we are. That's why most of us aren't doing hunting, or gathering, or farming, because we developed machines and other technologies to feed us with much less human labor input, and we have used that reallocation of our time and energy to write books and invent other things. That's going to happen here.The name of the game for us humans, there's two things: One is figuring out what does it mean to be a great human and over-index on that, and two, lay the foundation so that these multiple overlapping revolutions, as they play out in multiple fields, can be governed wisely. That is the name of the game. So when people say, “Is it going to change our lives?” I think people are thinking of it in the wrong way. This shirt that I'm wearing, this same shirt five years from now, you'll say, “Well, is there AI in your shirt?” — because it doesn't look like AI — and what I'm going to say is “Yes, in the manufacturing of this thread, in the management of the supply chain, in figuring out who gets to go on vacation, when, in the company that's making these buttons.” It's all these little things. People will just call it progress. People are imagining magic AI, all of these interwoven technologies will just feel like accelerating progress, and that will just feel like life.Normalizing the extraordinary (9:46)20, 30 years ago we didn't have the internet. I think things get so normalized that this just feels like life.What you're describing is a technology that economists would call a general-purpose technology. It's a technology embedded in everything, it's everywhere in the economy, much as electricity.What you call “boring AI,” the way I think about it is: I was just reading a Wall Street Journal story about Applebee's talking about using AI for more efficient customer loyalty programs, and they would use machine vision to look at their tables to see if they were cleaned well enough between customers. That, to people, probably doesn't seem particularly science-fictional. It doesn't seem world-changing. Of course, faster growth and a more productive economy is built on those little things, but I guess I would still call those “boring AI.”What to me definitely is not boring AI is the sort of combinatorial aspect that you're talking about where you're talking about AI helping the scientific discovery process and then interweaving with other technologies in kind of the classic Paul Romer combinatorial way.I think a lot of people, if they look back at their lives 20 or 30 years ago, they would say, “Okay, more screen time, but probably pretty much the same.”I don't think they would say that. 20, 30 years ago we didn't have the internet. I think things get so normalized that this just feels like life. If you had told ourselves 30 years ago, “You're going to have access to all the world's knowledge in your pocket.” You and I are — based on appearances, although you look so youthful — roughly the same age, so you probably remember, “Hurry, it's long distance! Run down the stairs!”We live in this radical science-fiction world that has been normalized, and even the things that you are mentioning, if you see open up your newsfeed and you see that there's this been incredible innovation in cancer care, and whether it's gene therapy, or autoimmune stuff, or whatever, you're not thinking, “Oh, that was AI that did that,” because you read the thing and it's like “These researchers at University of X,” but it is AI, it is electricity, it is agriculture. It's because our ancestors learned how to plant seeds and grow plants where you're stationed and not have to do hunting and gathering that you have had this innovation that is keeping your grandmother alive for another 10 years.What you're describing is what I call “magical AI,” and that's not how it works. Some of the stuff is magical: the Jetsons stuff, and self-driving cars, these things that are just autopilot airplanes, we live in a world of magical science fiction and then whenever something shows up, we think, “Oh yeah, no big deal.” We had ChatGPT, now ChatGPT, no big deal?If you had taken your grandparents, your parents, and just said, “Hey, I'm going to put you behind a screen. You're going to have a conversation with something, with a voice, and you're going to do it for five hours,” and let's say they'd never heard of computers and it was all this pleasant voice. In the end they said, “You just had a five-hour conversation with a non-human, and it told you about everything and all of human history, and it wrote poems, and it gave you a recipe for kale mush or whatever you're eating,” you'd say, “Wow!” I think that we are living in that sci-fi world. It's going to get faster, but every innovation, we're not going to say, “Oh, AI did that.” We're just going to say, “Oh, that happened.”Engineering intelligence (13:53)I don't like the word “artificial intelligence” because artificial intelligence means “artificial human intelligence.” This is machine intelligence, which is inspired by the products of human intelligence, but it's a different form of intelligence . . .I sometimes feel in my own writing, and as I peruse the media, like I read a lot more about AI, the digital economy, information technology, and I feel like I certainly write much less about genetic engineering, biotechnology, which obviously is a key theme in your book. What am I missing right now that's happening that may seem normal five years from now, 10 years, but if I were to read about it now or understand it now, I'd think, “Well, that is kind of amazing.”My answer to that is kind of everything. As I said before, we are at the very beginning of this new era of life on earth where one species, among the billions that have ever lived, suddenly has the increasing ability to engineer novel intelligence and re-engineer life.We have evolved by the Darwinian processes of random mutation and natural selection, and we are beginning a new phase of life, a new Cambrian Revolution, where we are creating, certainly with this novel intelligence that we are birthing — I don't like the word “artificial intelligence” because artificial intelligence means “artificial human intelligence.” This is machine intelligence, which is inspired by the products of human intelligence, but it's a different form of intelligence, just like dolphin intelligence is a different form of intelligence than human intelligence, although we are related because of our common mammalian route. That's what's happening here, and our brain function is roughly the same as it's been, certainly at least for tens of thousands of years, but the AI machine intelligence is getting smarter, and we're just experiencing it.It's become so normalized that you can even ask that question. We live in a world where we have these AI systems that are just doing more and cooler stuff every day: driving cars, you talked about discoveries, we have self-driving laboratories that are increasingly autonomous. We have machines that are increasingly writing their own code. We live in a world where machine intelligence has been boxed in these kinds of places like computers, but very soon it's coming out into the world. The AI revolution, and machine-learning revolution, and the robotics revolution are going to be intersecting relatively soon in meaningful ways.AI has advanced more quickly than robotics because it hasn't had to navigate the real world like we have. That's why I'm always so mindful of not denigrating who we are and what we stand for. Four billion years of evolution is a long time. We've learned a lot along the way, so it's going to be hard to put the AI and have it out functioning in the world, interacting in this world that we have largely, but not exclusively, created.But that's all what's coming. Some specific things: 30 years from now, my guess is many people who are listening to this podcast will be fornicating regularly with robots, and it'll be totally normal and comfortable.. . . I think some people are going to be put off by that.Yeah, some people will be put off and some people will be turned on. All I'm saying is it's going to be a mix of different —Jamie, what I would like to do is be 90 years old and be able to still take long walks, be sharp, not have my knee screaming at me. That's what I would like. Can I expect that?I think this can help, but you have to decide how to behave with your personalized robot.That's what I want. I'm looking for the achievement of human suffering. Will there be a world of less human suffering?We live in that world of less human suffering! If you just look at any metric of anything, this is the best time to be alive, and it's getting better and better. . . We're living longer, we're living healthier, we're better educated, we're more informed, we have access to more and better food. This is by far the best time to be alive, and if we don't massively screw it up, and frankly, even if we do, to a certain extent, it'll continue to get better.I write about this in Superconvergence, we're moving in healthcare from our world of generalized healthcare based on population averages to precision healthcare, to predictive and preventive. In education, some of us, like myself, you have had access to great education, but not everybody has that. We're going to have access to fantastic education, personalized education everywhere for students based on their own styles of learning, and capacities, and native languages. This is a wonderful, exciting time.We're going to get all of those things that we can hope for and we're going to get a lot of things that we can't even imagine. And there are going to be very real potential dangers, and if we want to have the good story, as I keep saying, and not have the bad story, now is the time where we need to start making the real investments.Distrust of disruption (19:44)Your job is the disruption of this thing that's come before. . . stopping the advance of progress is just not one of our options.I think some people would, when they hear about all these changes, they'd think what you're telling them is “the bad story.”I just talked about fornicating with robots, it's the bad story?Yeah, some people might find that bad story. But listen, we live at an age where people have recoiled against the disruption of trade, for instance. People are very allergic to the idea of economic disruption. I think about all the debate we had over stem cell therapy back in the early 2000s, 2002. There certainly is going to be a certain contingent that, what they're going to hear what you're saying is: you're going to change what it means to be a human. You're going to change what it means to have a job. I don't know if I want all this. I'm not asking for all this.And we've seen where that pushback has greatly changed, for instance, how we trade with other nations. Are you concerned that that pushback could create regulatory or legislative obstacles to the kind of future you're talking about?All of those things, and some of that pushback, frankly, is healthy. These are fundamental changes, but those people who are pushing back are benchmarking their own lives to the world that they were born into and, in most cases, without recognizing how radical those lives already are, if the people you're talking about are hunter-gatherers in some remote place who've not gone through domestication of agriculture, and industrialization, and all of these kinds of things, that's like, wow, you're going from being this little hunter-gatherer tribe in the middle of Atlantis and all of a sudden you're going to be in a world of gene therapy and shifting trading patterns.But the people who are saying, “Well, my job as a computer programmer, as a whatever, is going to get disrupted,” your job is the disruption. Your job is the disruption of this thing that's come before. As I said at the start of our conversation, stopping the advance of progress is just not one of our options.We could do it, and societies have done it before, and they've lost their economies, they've lost their vitality. Just go to Europe, Europe is having this crisis now because for decades they saw their economy and their society, frankly, as a museum to the past where they didn't want to change, they didn't want to think about the implications of new technologies and new trends. It's why I am just back from Italy. It's wonderful, I love visiting these little farms where they're milking the goats like they've done for centuries and making cheese they've made for centuries, but their economies are shrinking with incredible rapidity where ours and the Chinese are growing.Everybody wants to hold onto the thing that they know. It's a very natural thing, and I'm not saying we should disregard those views, but the societies that have clung too tightly to the way things were tend to lose their vitality and, ultimately, their freedom. That's what you see in the war with Russia and Ukraine. Let's just say there are people in Ukraine who said, “Let's not embrace new disruptive technologies.” Their country would disappear.We live in a competitive world where you can opt out like Europe opted out solely because they lived under the US security umbrella. And now that President Trump is threatening the withdrawal of that security umbrella, Europe is being forced to race not into the future, but to race into the present.Risk tolerance (24:08). . . experts, scientists, even governments don't have any more authority to make these decisions about the future of our species than everybody else.I certainly understand that sort of analogy, and compared to Europe, we look like a far more risk-embracing kind of society. Yet I wonder how resilient that attitude — because obviously I would've said the same thing maybe in 1968 about the United States, and yet a decade later we stopped building nuclear reactors — I wonder how resilient we are to anything going wrong, like something going on with an AI system where somebody dies. Or something that looks like a cure that kills someone. Or even, there seems to be this nuclear power revival, how resilient would that be to any kind of accident? How resilient do you think are we right now to the inevitable bumps along the way?It depends on who you mean by “we.” Let's just say “we” means America because a lot of these dawns aren't the first ones. You talked about gene therapy. This is the second dawn of gene therapy. The first dawn came crashing into a halt in 1999 when a young man at the University of Pennsylvania died as a result of an error carried out by the treating physicians using what had seemed like a revolutionary gene therapy. It's the second dawn of AI after there was a lot of disappointment. There will be accidents . . .Let's just say, hypothetically, there's an accident . . . some kind of self-driving car is going to kill somebody or whatever. And let's say there's a political movement, the Luddites that is successful, and let's just say that every self-driving car in America is attacked and destroyed by mobs and that all of the companies that are making these cars are no longer able to produce or deploy those cars. That's going to be bad for self-driving cars in America — it's not going to be bad for self-driving cars. . . They're going to be developed in some other place. There are lots of societies that have lost their vitality. That's the story of every empire that we read about in history books: there was political corruption, sclerosis. That's very much an option.I'm a patriotic American and I hope America leads these revolutions as long as we can maintain our values for many, many centuries to come, but for that to happen, we need to invest in that. Part of that is investing now so that people don't feel that they are powerless victims of these trends they have no influence over.That's why all of my work is about engaging people in the conversation about how do we deploy these technologies? Because experts, scientists, even governments don't have any more authority to make these decisions about the future of our species than everybody else. What we need to do is have broad, inclusive conversations, engage people in all kinds of processes, including governance and political processes. That's why I write the books that I do. That's why I do podcast interviews like this. My Joe Rogan interviews have reached many tens of millions of people — I know you told me before that you're much bigger than Joe Rogan, so I imagine this interview will reach more than that.I'm quite aspirational.Yeah, but that's the name of the game. With my last book tour, in the same week I spoke to the top scientists at Lawrence Livermore National Laboratory and the seventh and eighth graders at the Solomon Schechter Hebrew Academy of New Jersey, and they asked essentially the exact same questions about the future of human genetic engineering. These are basic human questions that everybody can understand and everybody can and should play a role and have a voice in determining the big decisions and the future of our species.To what extent is the future you're talking about dependent on continued AI advances? If this is as good as it gets, does that change the outlook at all?One, there's no conceivable way that this is as good as it gets because even if the LLMs, large language models — it's not the last word on algorithms, there will be many other philosophies of algorithms, but let's just say that LLMs are the end of the road, that we've just figured out this one thing, and that's all we ever have. Just using the technologies that we have in more creative ways is going to unleash incredible progress. But it's certain that we will continue to have innovations across the field of computer science, in energy production, in algorithm development, in the ways that we have to generate and analyze massive data pools. So we don't need any more to have the revolution that's already started, but we will have more.Politics always, ultimately, can trump everything if we get it wrong. But even then, even if . . . let's just say that the United States becomes an authoritarian, totalitarian hellhole. One, there will be technological innovation like we're seeing now even in China, and two, these are decentralized technologies, so free people elsewhere — maybe it'll be Europe, maybe it'll be Africa or whatever — will deploy these technologies and use them. These are agnostic technologies. They don't have, as I said at the start, an inevitable outcome, and that's why the name of the game for us is to weave our best values into this journey.What is a “newnimal”? (30:11). . . we don't live in a state of nature, we live in a world that has been massively bio-engineered by our ancestors, and that's just the thing that we call life.When I was preparing for this interview and my research assistant was preparing, I said, “We have to have a question about bio-engineered new animals.” One, because I couldn't pronounce your name for these . . . newminals? So pronounce that name and tell me why we want these.It's a made up word, so you can pronounce it however you want. “Newnimals” is as good as anything.We already live in a world of bio-engineered animals. Go back 50,000 years, find me a dog, find me a corn that is recognizable, find me rice, find me wheat, find me a cow that looks remotely like the cow in your local dairy. We already live in that world, it's just people assume that our bioengineered world is some kind of state of nature. We already live in a world where the size of a broiler chicken has tripled over the last 70 years. What we have would have been unrecognizable to our grandparents.We are already genetically modifying animals through breeding, and now we're at the beginning of wanting to have whatever those same modifications are, whether it's producing more milk, producing more meat, living in hotter environments and not dying, or whatever it is that we're aiming for in these animals that we have for a very long time seen not as ends in themselves, but means to the alternate end of our consumption.We're now in the early stages xenotransplantation, modifying the hearts, and livers, and kidneys of pigs so they can be used for human transplantation. I met one of the women who has received — and seems to so far to be thriving — a genetically modified pig kidney. We have 110,000 people in the United States on the waiting list for transplant organs. I really want these people not just to survive, but to survive and thrive. That's another area we can grow.Right now . . . in the world, we slaughter about 93 billion land animals per year. We consume 200 million metric tons of fish. That's a lot of murder, that's a lot of risk of disease. It's a lot of deforestation and destruction of the oceans. We can already do this, but if and when we can grow bioidentical animal products at scale without having all of these negative externalities of whether it's climate change, environmental change, cruelty, deforestation, increased pandemic risk, what a wonderful thing to do!So we have these technologies and you mentioned that people are worried about them, but the reason people are worried about them is they're imagining that right now we live in some kind of unfettered state of nature and we're going to ruin it. But that's why I say we don't live in a state of nature, we live in a world that has been massively bio-engineered by our ancestors, and that's just the thing that we call life.Inspired by curiosity (33:42). . . the people who I love and most admire are the people who are just insatiably curious . . .What sort of forward thinkers, or futurists, or strategic thinkers of the past do you model yourself on, do you think are still worth reading, inspired you?Oh my God, so many, and the people who I love and most admire are the people who are just insatiably curious, who are saying, “I'm going to just look at the world, I'm going to collect data, and I know that everybody says X, but it may be true, it may not be true.” That is the entire history of science. That's Galileo, that's Charles Darwin, who just went around and said, “Hey, with an open mind, how am I going to look at the world and come up with theses?” And then he thought, “Oh s**t, this story that I'm coming up with for how life advances is fundamentally different from what everybody in my society believes and organizes their lives around.” Meaning, in my mind, that's the model, and there are so many people, and that's the great thing about being human.That's what's so exciting about this moment is that everybody has access to these super-empowered tools. We have eight billion humans, but about two billion of those people are just kind of locked out because of crappy education, and poor water sanitation, electricity. We're on the verge of having everybody who has a smartphone has the possibility of getting a world-class personalized education in their own language. How many new innovations will we have when little kids who were in slums in India, or in Pakistan, or in Nairobi, or wherever who have promise can educate themselves, and grow up and cure cancers, or invent new machines, or new algorithms. This is pretty exciting.The summary of the people from the past, they're kind of like the people in the present that I admire the most, are the people who are just insatiably curious and just learning, and now we have a real opportunity so that everybody can be their own Darwin.On sale everywhere The Conservative Futurist: How To Create the Sci-Fi World We Were PromisedMicro Reads▶ Economics* AI Hype Is Proving to Be a Solow's Paradox - Bberg Opinion* Trump Considers Naming Next Fed Chair Early in Bid to Undermine Powell - WSJ* Who Needs the G7? - PS* Advances in AI will boost productivity, living standards over time - Dallas Fed* Industrial Policy via Venture Capital - SSRN* Economic Sentiment and the Role of the Labor Market - St. Louis Fed▶ Business* AI valuations are verging on the unhinged - Economist* Nvidia shares hit record high on renewed AI optimism - FT* OpenAI, Microsoft Rift Hinges on How Smart AI Can Get - WSJ* Takeaways From Hard Fork's Interview With OpenAI's Sam Altman - NYT* Thatcher's legacy endures in Labour's industrial strategy - FT* Reddit vows to stay human to emerge a winner from artificial intelligence - FT▶ Policy/Politics* Anthropic destroyed millions of print books to build its AI models - Ars* Don't Let Silicon Valley Move Fast and Break Children's Minds - NYT Opinion* Is DOGE doomed to fail? Some experts are ready to call it. - Ars* The US is failing its green tech ‘Sputnik moment' - FT▶ AI/Digital* Future of Work with AI Agents: Auditing Automation and Augmentation Potential across the U.S. Workforce - Arxiv* Is the Fed Ready for an AI Economy? - WSJ Opinion* How Much Energy Does Your AI Prompt Use? I Went to a Data Center to Find Out. - WSJ* Meta Poaches Three OpenAI Researchers - WSJ* AI Agents Are Getting Better at Writing Code—and Hacking It as Well - Wired* Exploring the Capabilities of the Frontier Large Language Models for Nuclear Energy Research - Arxiv▶ Biotech/Health* Google's new AI will help researchers understand how our genes work - MIT* Does using ChatGPT change your brain activity? Study sparks debate - Nature* We cure cancer with genetic engineering but ban it on the farm. - ImmunoLogic* ChatGPT and OCD are a dangerous combo - Vox▶ Clean Energy/Climate* Is It Too Soon for Ocean-Based Carbon Credits? - Heatmap* The AI Boom Can Give Rooftop Solar a New Pitch - Bberg Opinion▶ Robotics/Drones/AVs* Tesla's Robotaxi Launch Shows Google's Waymo Is Worth More Than $45 Billion - WSJ* OpenExo: An open-source modular exoskeleton to augment human function - Science Robotics▶ Space/Transportation* Bezos and Blue Origin Try to Capitalize on Trump-Musk Split - WSJ* Giant asteroid could crash into moon in 2032, firing debris towards Earth - The Guardian▶ Up Wing/Down Wing* New Yorkers Vote to Make Their Housing Shortage Worse - WSJ* We Need More Millionaires and Billionaires in Latin America - Bberg Opinion▶ Substacks/Newsletters* Student visas are a critical pipeline for high-skilled, highly-paid talent - AgglomerationsState Power Without State Capacity - Breakthrough JournalFaster, Please! is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit fasterplease.substack.com/subscribe

Grab your consent forms (but don't sign them yet) and your government-issued fetal monitoring bracelet, because today we're getting a broader understanding of what happens when people aren't treated like people but like data, vessels, and experiments. The body keeps the score- even when it's for medical horror stories. From Adriana Smith, kept alive against her will to serve as a human incubator under Georgia's abortion laws, to Henrietta Lacks, whose cells were stolen, immortalized, and monetized without her knowledge or family's consent, this episode unpacks the long, horrifying legacy of unethical medical research in America. We'll walk through the Tuskegee Syphilis Study, the Holmesburg Prison experiments, the HIV-tainted blood scandal that infected kids like Ryan White, while the government spent more money on the Tylenol murders than AIDS research. And this isn't ancient history, it's happening today- not just with Adriana Smith, or Terri Schiavo as a human prop before her but with forced sterilizations, CRISPR babies, and what happens when “the greater good” doesn't include you. This isn't an anti-science episode. I'm pro-science, but not when the most marganilzed among us have to die for it. And in a world where women, people of color, and the poor are still being used, sometimes even after death- it's more important than ever to ask: Who gets to be a patient? And who's just a test subject?Become a supporter of this podcast: https://www.spreaker.com/podcast/broads-next-door--5803223/support.

Last month, scientists reported a historic first: they gave the first personalized gene-editing treatment to a baby who was born with a rare life-threatening genetic disorder. Before the treatment, his prognosis was grim. But after three doses, the baby's health improved. So how does it work? What are the risks? And what could this breakthrough mean for the 30 million people in the US who have a rare genetic disease with no available treatments?To help get some answers, Host Flora Lichtman is joined by the physician-scientists who led this research: geneticist Dr. Kiran Musunuru and pediatrician Dr. Rebecca Ahrens-Nicklas.Guests: Dr. Rebecca Ahrens-Nicklas is an assistant professor of pediatrics and genetics at the Children's Hospital of Philadelphia and the University of Pennsylvania.Dr. Kiran Musunuru is a professor of translational research at the University of Pennsylvania.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Brian Frank, the founder and general partner at FTW Ventures, shares why he left his founder career to invest in startups solving real-world problems starting with the global food system. He explores the climate risks, supply chain fragility, and health challenges driving the need for innovation in food and agriculture. From AI and biotech to automation, Brian highlights where the biggest opportunities lie. He also offers candid advice for founders navigating slow-moving, regulation-heavy industries and calls for a more collaborative, mission-aligned approach to venture capital.In this episode, you'll learn:[03:35] How startup success as a student got Brian hooked on innovation early[05:54] Why Brian left startup life after seven companies to support founders solving global problems[09:18] The urgent reasons our food system needs reinvention—from climate to national security[12:33] FTW Ventures investment philosophy and focus areas[22:50] Hard truths for founders in food and agriculture[31:13] The story of a founder who proved his market, didn't wait for funding, and built trust[37:05] What needs to change in VC: stop party rounds, leave space for small funds, invest with purposeThe nonprofit organization Brian is passionate about: World Central KitchenAbout Brian FrankBrian Frank is the founder and general partner at FTW Ventures, a venture capital firm focused on technology solutions in food, agriculture, and health. A serial entrepreneur with a background in computer science and product development, Brian has launched and scaled seven startups. He brings that hands-on experience to founders tackling real-world challenges, backing science-backed and mission-driven companies that aim to improve life on the planet.About FTW VenturesFTW Ventures is a Silicon Valley-based venture capital firm investing in the future of food, agriculture, and human health. With a thesis grounded in problem-first investing, FTW backs early-stage startups applying biotechnology, artificial intelligence, automation, and sustainable systems to global challenges. Their portfolio includes companies advancing biomanufacturing, food-as-medicine, CRISPR-based crop innovation, and more—pursuing returns across people, planet, and profit. Companies in FTW's portfolio include Boston Bioprocess, ALTR, Sylvan Health, FreshFry, Izote Biosciences, Arise, Quorum Bio, Earthodic, Heritable, Brilliant Harvest, VoltAir, Geltor, Spoiler Alert, Plantible Foods, Galley, Phytoform, Nfinite Nanotech, Yali Bio, and Debut Biotechnology.Subscribe to our podcast and stay tuned for our next episode.

Christians mostly think of Iran as one of the nations that Ezekiel prophesies will invade Israel in the last days. There is a lesser-known prophecy which offers a glimpse of a restoration of Iran. Pastor Gene Pensiero Find audio, video, and text of hundreds of other prophecy updates at: https://calvaryhanford.com/prophecy Read along with us at […]

This week on The Nerdpocalypse Podcast, the guys return to discuss Duster, CRISPR new innovation on chromosome editing that creates some moral issues potentially, Tyler Perry accused of exactly what you'd assume he'd be accused of, first look at He-Man is interesting, Clayface solo film gets its lead, is Mindhunters going to return?, more Pirates movies, Rachel Brosnahan has a message for actors in superhero movies, and much more.CHECKED OUTDusterSCIENCE & TECH NEWSCRISPR used to remove extra chromosomesTOPICS - Section 1Tyler Perry accused of sexual assault in actor's $260m lawsuitFirst look at He-Man is well…ok sure. Umm okMike Flanagan's Clayface solo movie finds its leadTNP STUDIOS PREMIUM (www.TheNerdpocalypse.com/premium)$5 a month Access to premium slate of podcasts incl. The Airing of Grievances, No Time to Bleed, The Men with the Golden Tongues, Upstage Conversation, and full episodes of the Look Forward political podcastTOPICS - Section 2Mindhunters may make a return!More Pirates of the Caribbean movies in the works but with or with Jack Sparrow?Rachel Brosnahan on acting not standing by their comic book moviesWTF? by JayTeeDee from the “Edit That Out” PodcastMicah: https://tinyurl.com/hell2danawJay: https://tinyurl.com/gwarlivesTRAILERS40 Acres

Ep 215 | This week on Discover Ag, Natalie and Tara break down the chaos and charm of Clarkson's Farm Season 4 from surprise restaurant launches to red tape and that abrupt, buzzworthy finale. Plus, new cast member Harriet sparks mixed reactions from fans and hosts alike. Next, the DISCOs tackle viral confusion over “bioengineered” food labels at Whole Foods and how influencers are turning GMO fear into follower gold. Also: solo dinners get real (string cheese and pizza in a robe, anyone?), lab-grown meat bans sweep the U.S., and upcoming expert guests promise a clash of opinions on CRISPR, glyphosate, and the future of food. Whether you're in it for ag policy or just to feel better about your microwave meal habits, this episode's got you. What We Discovered This Week

Cory grew up in Maine and after spending time as a sea kayak guide and a ski instructor, found his way to biology and laboratory research. Currently a Postdoctoral Researcher in the Haller Lab at MDI Biological Laboratory, Cory is interested in the cell biology of kidney vascularization and uses renal organoids and zebrafish to investigate how we may, one day, be able to rebuild the kidney and develop non-donor solutions to kidney transplantation.Cory was one of the 5 Minute Genius™ speakers at this past year's Maine Science Festival; you can see his talk on our YouTube channel.This conversation was recorded in May 2025. ~~~~~The Maine Science Podcast is a production of the Maine Discovery Museum. It is recorded at Discovery Studios, at the Maine Discovery Museum, in Bangor, ME. The Maine Science Podcast is hosted and executive produced by Kate Dickerson; edited and produced by Scott Loiselle. The Discover Maine theme was composed and performed by Nick Parker. To support our work: https://www.mainediscoverymuseum.org/donate. Find us online:Maine Discovery MuseumMaine Discovery Museum on social media: Facebook Instagram LinkedIn Bluesky Maine Science Festival on social media: Facebook Instagram LinkedInMaine Science Podcast on social media: Facebook Instagram © 2025 Maine Discovery Museum

My guest today is someone whose work has shaped the very code of modern biology, and whose vision continues to ripple across fields as vast as genomics, synthetic biology, age reversal, and artificial intelligence.Dr. George Church is a a true pioneer, Professor of Genetics at Harvard Medical School,a molecular engineer, chemist and serial entrepreneur as the co-founder of more than 50 biotech companies. He has helped invent many of the technologies that now define the genomic era, from CRISPR optimization to DNA data storage, and he was one of the first humans to ever publicly share his full genome and medical history.In this conversation, we explore the edge where science meets spirit.We talk about synthetic biology as a modern myth, DNA as a vessel of intelligence, and what it means to engineer life with intention. We dive into radical transparency, longevity research, AI collaboration, and the philosophical gravity of rewriting the arc of aging.This episode is not just about technology. It is about becoming.It is about asking: What does it mean to choose our evolution, consciously, ethically, and with awe.Episode highlights:00:04:30 – Sleep states and engineered serendipity: tapping creativity through unconscious rhythms00:06:30 – Synthetic biology as a modern myth: Promethean fire and the sacred aesthetic of science00:08:30 – DNA as memory, medium, and myth: encoding images in bacterial genomes00:10:00 – Is DNA a vessel of intelligence beyond biology?00:13:30 – Preserving culture in encoded DNA: who might decode it in the far future?00:16:00 – Are we alone in the universe? Dr. Church's speculative yet grounded view00:18:30 – What should we preserve for the next million years? The humility of legacy00:21:00 – DNA as sacred text: what it teaches us about identity, ancestry, and consciousness00:24:00 – Radical transparency: the Personal Genome Project and sharing his own genome00:29:00 – Rethinking consent, privacy, and research ethics in human genomics00:32:00 – From printing press to gene sequencers: the dawn of programmable biology00:33:30 – From slowing aging to redesigning it: reprogramming human cells and organs00:36:00 – How smarter gene, cell, and organ therapies could surpass pharmaceuticals00:40:00 – Personalized vs. generic medicine: the case for affordable global health00:43:30 – Aging as a treatable condition: tackling multiple pathways at once00:46:30 – Ethical and spiritual questions at the threshold of biological reinvention00:49:00 – The risks of artificial general intelligence vs. the promise of scientific AI00:52:30 – Why narrow scientific AI (like protein design) offers real-world breakthroughs00:54:30 – Will synthetic intelligence ever hold ethical responsibility?00:55:00 – Final reflections: safety, accessibility, and helping humanity fulfill its potentialResources mentioned:WebsitesWyss Institute: https://wyss.harvard.edu/team/core-faculty/george-church/Harvard Department of Genetics: https://icgd.bwh.harvard.edu/team/george-churchBiophysics at Harvard: https://biophysics.fas.harvard.edu/people/george-m-churchChurch Lab:

Josh Peck talks about scientific achievements that point to us entering the days of Noah. Also included is an interview with Gary Stearman.To get the audio-only podcast version of full videos and Josh Peck's blog, which includes original articles, show notes, and more, subscribe to Josh's Substack at http://joshpeck.substack.comDonate: http://PayPal.me/JoshPeckDisclosureCashApp: $JoshScottPeck

From baby blood to breakthrough cures — we explore how unlocking fetal hemoglobin through gene editing (exa-cel/Casgevy) is transforming treatment for sickle cell disease and β-thalassemia.

The microbiome is emerging as a key player in the effectiveness of CAR-T therapy, and today, Dr. Melody Smith, Assistant Professor of Medicine at Stanford University, sheds light on this fascinating intersection. Join us as we explore how advancements in CAR T-cell therapy are reshaping patient demographics and treatment approaches. Dr. Smith will discuss the implications of genetic engineering techniques like CRISPR, the importance of a multidisciplinary treatment strategy, and the role of antibiotic stewardship in optimizing outcomes. With insights into innovative therapies and ongoing clinical trials, this conversation promises to deepen your understanding of CAR-T therapy and its complexities, offering a glimpse into the future of cancer treatment. Read Transcription CME Information: https://stanford.cloud-cme.com/medcastepisode107 Claim CE: https://stanford.cloud-cme.com/Form.aspx?FormID=3392

"Certainly, I've been anxious about data...I did an experiment, I put a lot of time into it, I'm hoping to get good results...we all know that feeling, right? The stakes are just so different here...this kid's life depends on whether this experiment worked." --Kiran Musunuru, MD, PhD One of the highlights of the ASGCT 28th Annual Meeting was the announcement on May 15 of a historic medical breakthrough: a child diagnosed with a rare genetic disorder had been successfully treated for the first time with a customized CRISPR gene editing therapy. The infant, KJ Muldoon, was born with a rare metabolic disease called severe carbamoyl phosphate synthetase 1 (CPS1) deficiency. When he was just six months old, KJ received his personalized therapy at the Children's Hospital of Philadelphia (CHOP), where ASGCT Members Kiran Musunuru, MD, PhD; and Rebecca Ahrens-Nicklas, MD, PhD; led the group of researchers who developed KJ's treatment. KJ is now growing and thriving. He recently left the hospital where he has spent the majority of his life. And the day after presenting the research that led to this first-of-its-kind development, Dr. Musunuru told us that there was so much more to the story. Listen to our first episode of Soundbites of the Annual Meeting with Dr. Kiran Musunuru. Did you attend the 28th Annual Meeting? Watch all sessions, including Dr. Musunuru's presentation, on demand on the virtual meeting platform through July 18! Not a member? Join now and receive 19 months of membership for the price of 12. Show your support for ASGCT!: https://asgct.org/membership/donateSee omnystudio.com/listener for privacy information.

AI Technology Series: https://www.soulreno.com/ai-future-tech-seriesInstagram: https://www.instagram.com/soulrenovation/?hl=en

A Note from James:Michael Dell. Founder of Dell. I remember in college, hearing about this kid who was building computers in his dorm and making millions. I thought it was a myth. It wasn't. He's the real thing—and he just kept going.I wanted to understand what drove him, what it felt like to deal with Carl Icahn trying to wrestle his company from him, and what success feels like after decades of being in the game. Also: I had to ask why Dell didn't invent Google. That, plus how he's now thinking about AI, cancer, and what “focus” really means.Episode Description:James Altucher sits down with Michael Dell, founder and CEO of Dell Technologies, to trace the entire arc of Dell's career—from building computers in a college dorm room to defending his company against Carl Icahn and taking it private. In this candid conversation, Dell shares how early obsession with tech and business turned into a multibillion-dollar global enterprise, the lessons he's learned about leadership, and how he's positioning for the future with AI, cybersecurity, and gene tech on the horizon.This is more than a business story. It's about risk, conviction, reinvention—and knowing when to walk away from Steve Jobs.What You'll Learn:How Dell's dorm-room business scaled to $80,000/month before he even left collegeWhat Michael Dell really thought during his showdown with Carl IcahnWhy most big companies fail to innovate—and how to keep a startup mindsetHow Dell Technologies is preparing for the explosion in AI and edge computingWhat makes a good leader at the head of a $100 billion companyTimestamped Chapters:[00:00] James introduces Michael Dell and the origin story of Dell Computers[01:00] The economics of building PCs in the early 1980s[03:00] Winning state bids with a bike and a dorm room[05:00] Pressure to become a doctor—and the 10-day “intervention”[10:00] Meeting Steve Jobs and licensing DOS from Bill Gates[13:00] Dell's early B2B focus and international expansion[15:00] Going public and the Icahn showdown[18:00] How activist investors play poker with billion-dollar stakes[21:00] What focus really means in business[24:00] Defining leadership at global scale[26:00] Encouraging innovation inside massive companies[28:00] The failed Mac OS licensing deal[30:00] Philanthropy, education, and urban poverty[33:00] COVID lockdowns and a $100M response[35:00] The future of work and city migration[39:00] AI, edge computing, and exponential data[42:00] Gene editing, mRNA vaccines, and solving cancer[45:00] Blockchain in enterprise (no bitcoin on Dell's balance sheet—yet)[47:00] Why cybersecurity is an arms raceAdditional Resources:Play Nice But Win – Michael Dell's memoir (Amazon)Dell Technologies – Official websiteJudge rejects Icahn's move on Dell buyout – CT InsiderRichard Florida on the future of cities – Vital City NYC interviewWhat is CRISPR? – Broad InstituteHistory of MS‑DOS – WikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In a medical first, a team at Children's Hospital of Philadelphia and Penn Medicine has successfully treated an infant diagnosed with a rare genetic disorder by using a customized CRISPR gene editing therapy. The work, led by Penn Medicine's Kiran Musunuru and CHOP's Rebecca Ahrens-Nicklas, points to the potential to use bespoke gene editing therapies to treat others with rare genetic diseases for which no available medicines exist. We spoke to P.J. Brooks, deputy director of the Office of Rare Disease Research at the National Institutes of Health's National Center for Advancing Translational Sciences, about the breakthrough treatment, how the researchers were able to move from diagnosis to treatment with great speed, and what it would take to scale such an approach.

Caller pot-shots: Long couple of calls! Ashli Babbitt: Maybe justified? Kush "fairy tale" rehashed! Should you forgive the unrepentant?The Hake Report, Wednesday, June 11, 2025 ADTIMESTAMPS* (0:00:00) Start* (0:00:56) Disclaimer, etc* (0:05:23) Hey, guys!* (0:10:10) News…* (0:12:50) CNN anti-2A propaganda* (0:21:23) CJ, WA: Sensitive; LYD; Spoiler Alert* (0:24:47) CJ: Ashli Babbitt…* (0:29:11) CJ: Kush vs Toynbee* (0:31:44) CJ: black societies, argument fallacies …* (0:38:26) CJ: Neanderthals, critically thinking out an argument* (0:44:07) CJ: Segregation won't happen; CRISPR genetics* (0:48:07) MARK, CA: Ashli wasn't justified* (0:53:25) MARK: "Historical community"* (1:00:50) MARK prays for Hake… Does he forgive CJ?* (1:13:48) Supers / Coffees / Rumble Rants* (1:26:11) ELIJAH, CA: Simping for black civilizations… Luba Sub-Saharan?* (1:30:30) ELIJAH: Ashli may still be alive; orchestrated events* (1:34:43) HADEN, TX: Kush, Mali, and Luba–bashing; multiculturalism* (1:40:14) ALLEN, MI… G.L. Rockwell, "Demons"* (1:44:47) HECTOR, L.A.: This is Aztlán; Women* (1:50:12) MANUEL, CA: India not doing well; Points* (1:54:00) OutroBLOG https://www.thehakereport.com/blog/2025/6/11/the-hake-report-wed-6-11-25PODCAST / Substack HAKE NEWS from JLP https://www.thehakereport.com/jlp-news/2025/6/11/jlp-wed-6-11-25–Hake is live M-F 9-11a PT (11-1CT/12-2ET) Call-in 1-888-775-3773 https://www.thehakereport.com/showVIDEO: YT - Rumble* - Pilled - FB - X - BitChute (Live) - Odysee*PODCAST: Substack - Apple - Spotify - Castbox - Podcast Addict*SUPER CHAT on platforms* above or BuyMeACoffee, etc.SHOP - Printify (new!) - Cameo | All My LinksJLP Network: JLP - Church - TFS - Nick - PunchieThe views expressed on this show do not represent those of BOND, Jesse Lee Peterson, the Network, this Host, or this platform. No endorsement or opposition implied!The show is for general information and entertainment, and everything should be taken with a grain of salt! Get full access to HAKE at thehakereport.substack.com/subscribe

What if we could rewrite the code of life—just like editing a Word doc?Gene-editing pioneer David Liu takes us behind the scenes of the revolutionary tools transforming medicine. He's the Harvard scientist who invented base editing—a breakthrough that lets scientists fix a single DNA letter to correct genetic disease at its root.This is science fiction come to life—and it's happening now. He edits DNA like we edit text. Come meet the man who's changing lives, one letter at a time. 

Jeremiah’s poetic picture of thriving livestock is a Millennial scene but we can see the stage being set for its fulfillment now. Pastor Gene Pensiero Find audio, video, and text of hundreds of other prophecy updates at: https://calvaryhanford.com/prophecy Read along with us at https://calvaryhanford.substack.com Follow us on YouTube at https://youtube.com/calvaryhanford — In Prophecy Update #824, […]

Brought to you by TogetherLetters & Edgewise!In this episode: The hottest new vibe coding startup may be a sitting duck for hackers​​Behind the Curtain: A white-collar bloodbathWindsurf says Anthropic is limiting its direct access to Claude AI modelsOpenAI slams court order to save all ChatGPT logs, including deleted chatsAfter groundbreaking CRISPR therapy, a homecoming​​Meta Apps Have Been Covertly Tracking Android Users' Web Activity for MonthsUsing AI to generate “UGC”Amazon set to test AI-powered humanoid robots for deliveries - reportWalmart is selling a $200 smartwatch for only $37, and shoppers say it's 'a great product for the money' WWDC is Upon UsThe Claude 4 System Card is a Wild ReadWeird and Wacky: 'No more floppy disks': Air traffic control overhaul faces some daunting obstaclesTech Rec:Joe - FlightyAdam - Zapiers new AI Agent BuilderFind us here:casabona.org & adamjwalker.comTech Talk Y'all is a proud production of Edgewise.Media.

Episode 10: The Future of Survival – Longevity Unlocked Episode Description What if living to 120—or even 150—becomes the norm? In this episode, we explore the explosive world of longevity science and how it could completely reshape prepping, survival, and society itself. From gene editing and AI-designed anti-aging drugs to population stress and a redefinition of retirement, it's time to think beyond your bug-out bag and start prepping for a second century of life. Episode Breakdown

South American cane toads were brought to Australia in 1935 to help eradicate native beetles that were destroying sugar cane crops. The toads didn't care much for the beetles, but they did spread across the coast of Queensland and beyond, with no natural predators to stop them. Their own deadly toxin devastated local reptiles along the way, and they now number over 200 million.Invasive biologists have long tried to curb Australia's cane toad population. The newest approach uses CRISPR gene-editing technology to create cannibalistic “Peter Pan” cane toad tadpoles: tadpoles that don't fully mature and instead feast on the tens of thousands of eggs that the toads produce.How was this approach developed, and how do these researchers think about making a potentially massive change to the ecosystem? Biologist Rick Shine, who has led the effort, joins Host Flora Lichtman to discuss it. Later, science journalist Elizabeth Kolbert talks about her experience reporting on similar monumental efforts to control nature—and what they say about us.Guests: Elizabeth Kolbert is a staff writer at The New Yorker and author of Under a White Sky: The Nature of the Future (Crown, 2021). She's based in Williamstown, Massachusetts.Dr. Rick Shine is a professor of biology at Macquarie University in Sydney, Australia.Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Show notes⁠ / Don't Die is more than just another health book. It mixes philosophy with science. Johnson sees aging as a disease we can beat. Read 1 million books in minutes. For free. Get the PDF, infographic, extended ad-free audiobook and animated version of this summary and unlimited bestselling book insights on the top-rated ⁠⁠StoryShots⁠⁠ app: ⁠⁠https://www.getstoryshots.com/ ⭐️⭐️⭐️⭐️⭐️ Don't forget to subscribe, rate and review the StoryShots podcast now.  What should our next book be? Suggest and vote it up on the ⁠⁠StoryShots⁠⁠ app. IN THIS EPISODE: Tech entrepreneur Brian Johnson proposes a radical, scientifically-backed approach to defeating aging through comprehensive health monitoring, strict lifestyle protocols, and cutting-edge experimental interventions. TOPICS: Longevity, nutrition, health, technology, biology KEY FIGURES: PayPal, Brian Johnson, CRISPR, Braintree, National Institute on Aging, don't die, StoryShots, Dr. Oliver Zollman, Blueprint Protocol SUMMARY: Brian Johnson, a tech entrepreneur and author of 'Don't Die', has developed an extreme approach to longevity that involves meticulously tracking and optimizing his health. At 47, he claims to have the body of an 18-year-old through a rigorous regimen that includes a strict 1,977-calorie vegan diet consumed within a five-hour window, taking over 100 pills daily, and following a comprehensive health protocol called Blueprint that monitors 81 different body systems. Johnson's methodology goes beyond traditional health practices, treating aging as a disease that can be conquered through systematic interventions. He uses advanced health tracking, including DNA methylation testing and inflammation markers, to guide his daily routines. His approach involves experimental therapies like blood exchange with his son and father, gene therapy interventions, and a unique sleep optimization strategy that creates an ideal rest environment. While Johnson's methods are controversial and expensive, costing over $2 million annually, he believes his work will eventually benefit everyone by pushing the boundaries of longevity research. His book 'Don't Die' presents a philosophical framework for understanding aging, emphasizing that most people live in 'slow suicide' by making short-term choices that harm long-term health. Johnson envisions a future where technology like gene editing, AI, and advanced biotechnology will make radical life extension possible and accessible. KEY QUOTES: • "As a species, we accept our decay, decline and death. I want to argue that the opposite should be true." - Brian Johnson • "Johnson says most people live in slow suicide. They make choices that feel good now but hurt their future selves." - Brian Johnson • "Johnson compares our body to computer software. We can update the code." - Brian Johnson • "Change is hard. Being miserable is harder." - Brian Johnson • "Before any decision, ask does this help me not die?" - Brian Johnson KEY TAKEAWAYS: • Brian Johnson views aging as a disease that can be 'solved' through systematic, data-driven interventions, spending over $2 million annually to track and potentially reverse his biological aging • Johnson's 'Don't Die' philosophy involves making every lifestyle choice through the lens of whether it helps or hurts long-term survival, including a strict 1,977-calorie vegan diet consumed within a 5-hour window and taking over 100 supplements daily • Johnson tracks 81 different body systems using advanced biomarkers like DNA methylation and inflammation markers, allowing him to make real-time adjustments to his health protocols • His approach combines cutting-edge experimental treatments like blood exchange with his son and gene therapy interventions, while acknowledging the current scientific uncertainty of these methods... Learn more about your ad choices. Visit megaphone.fm/adchoices

This week we talk about gene-editing, CRISPR/Cas9, and ammonia.We also discuss the germ line, mad scientists, and science research funding.Recommended Book: The Siren's Call by Chris HayesTranscriptBack in November of 2018, a Chinese scientist named He Jiankui achieved global notoriety by announcing that he had used a relatively new gene-editing technique on human embryos, which led to the birth of the world's first gene-edited babies.His ambition was to help people with HIV-related fertility problems, one of which is that if a parent is HIV positive, there's a chance they could transmit HIV to their child.This genetic modification was meant to confer immunity to HIV to the children so that wouldn't be an issue. And in order to accomplish that immunity, He used a technology called CRISPR/Cas9 to modify the embryos' DNA to remove their CCR5 gene, which is related to immune system function, but relevant to this undertaking, also serves as a common pathway for the HIV-1 virus, allowing it to infect a new host.CRISPR is an acronym that stands for clustered regularly interspaced short palindromic repeats, and that refers to a type of DNA sequence found in all sorts of genomes, including about half of all sequenced bacterial genomes and just shy of 90% of all sequenced archaea genomes.Cas9 stands for CRISPR-associated protein 9, which is an enzyme that uses CRISPR sequences, those repeating, common sequences in DNA strands, to open up targeted DNA strands—and when paired with specific CRISPR sequences, this duo can search for selected patterns in DNA and then edit those patterns.This tool, then, allows researchers who know the DNA pattern representing a particular genetic trait—a trait that moderates an immune system protein that also happens to serve as a convenient pathway for HIV, for instance—to alter or eliminate that trait. A shorthand and incomplete way of thinking about this tool is as a sort of find and replace tool like you have in a text document on your computer, and in this instance, the gene sequence being replaced is a DNA strand that causes a trait that in turn leads to HIV susceptibility.So that's what He targeted in those embryos, and the children those embryos eventually became, who are usually referred to as Lulu and Nana, which are pseudonyms, for their privacy, they were the first gene-edited babies; though because of the gene-editing state of the art at the time, while He intended to render these babies' CCR5 gene entirely nonfunctional, which would replicate a natural mutation that's been noted in some non-gene-edited people, including the so-called Berlin Patient, who was a patient in Germany in the late-90s who was functionally cured of HIV—the first known person to be thus cured—while that's what He intended to do, instead these two babies actually carry both a functional and a mutant copy of CCR5, not just the mutant one, which in theory means they're not immune to HIV, as intended.Regardless of that outcome, which may be less impactful than He and other proponents of this technology may have hoped, He achieved superstardom, briefly, even being named one of the most influential people in the world by Time magazine in 2019. But he was also crushed by controversy, stripped of his license to conduct medical research by the Chinese government, sent to prison for three years and fined 3 million yuan, which is more than $400,000, and generally outcast from the global scientific community for ethical violations, mostly because the type of gene-editing he did wasn't a one-off sort of thing, it was what's called germ-line editing, which means those changes won't just impact Lulu and Nana, they'll be passed on to their children, as well, and their children's children, and so on.And the ethical implications of germ-line editing are so much more substantial because while a one-off error would be devastating to the person who suffers it, such an error that is passed on to potentially endless future generations could, conceivably, end humanity.The error doesn't even have to be a botched job, it could be an edit that makes the edited child taller or more intelligent by some measure, or more resistant to a disease, like HIV—but because this is fringy science and we don't fully understand how changing one thing might change other things, the implications for such edits are massive.Giving someone an immunity to HIV would theoretically be a good thing, then, but if that edit then went on the market and became common, we might see a generation of humans that are immune to HIV, but potentially more susceptible to something else, or maybe who live shorter lives, or maybe who create a subsequent generation who themselves are prone to all sorts of issues we couldn't possibly have foreseen, because we made these edits without first mapping all possible implications of making that genetic tweak, and we did so in such a way that those edits would persist throughout the generations.What I'd like to talk about today is another example of a similar technology, but one that's distinct enough, and which carries substantially less long-term risk, that it's being greeted primarily with celebration rather than concern.—In early August of 2024, a gene-editing researcher at the University of Pennsylvania, Dr. Kiran Musunuru, was asked if there was anything he could do to help a baby that was being treated at the Children's Hospital of Philadelphia for CPS1 deficiency, which manifests as an inability to get rid of the ammonia that builds up in one's body as a byproduct of protein metabolism.We all generate a small amount of ammonia just as a function of living, and this deficiency kept the baby from processing and discarding that ammonia in the usual fashion. As a result, ammonia was building up in its blood and crossing into its brain.The usual method of dealing with this deficiency is severely restricting the suffer's protein intake so that less ammonia is generated, but being a baby, that meant it wasn't able to grow; he was getting just enough protein to survive and was in the 7th percentile for body weight.So a doctor at the Children's Hospital wanted to see if there was anything this gene-editing researcher could do to help this baby, who was at risk of severe brain damage or death because of this condition he was born with.Gene-editing is still a very new technology, and CRISPR and associated technologies are even newer, still often resulting in inaccurate edits, many of which eventually go away, but that also means the intended edit sometimes goes away over time, too—the body's processes eventually replacing the edited code with the original.That said, these researchers, working with other researchers at institutions around the world, though mostly in the US, were able to rush a usually very cumbersome and time-consuming process that would typically take nearly a decade, and came up with and tested a gene-editing approach to target the specific mutation that was causing this baby's problems, and they did it in record time: the original email asking if Dr Musunuru might be able to help arrived in August of 2024, and in late-February of 2025, the baby received his first infusion of the substance that would make the proper edits to his genes; they divided the full, intended treatment into three doses, the first being very small, because they didn't know how the baby would respond to it, and they wanted to be very, very cautious.There were positive signs within the first few weeks, so 22 days later, they administered the second dose, and the third followed after that.Now the research and medical worlds are waiting to see if the treatment sticks; the baby is already up to the 40th percentile in terms of weight for his age, is able to eat a lot more protein and is taking far less medication to help him deal with ammonia buildup, but there's a chance that he may still need a liver transplant, that there might be unforeseen consequences due to that intended edit, or other, accidental edits made by the treatment, or, again, that the edits won't stick, as has been the case in some previous trials.Already this is being heralded as a big success, though, as the treatment seems to be at least partially successful, hasn't triggered any serious, negative consequences, and has stuck around for a while—so even if further treatments are needed to keep the gene edited, there's a chance this could lead to better and better gene-editing treatments in the future, or that such treatments could replace some medications, or be used for conditions that don't have reliable medications in the first place.This is also the first known case of a human of any age being given a custom gene-editing treatment (made especially for them, rather than being made to broadly serve any patient with a given ailment or condition), and in some circles that's considered to be the future of this field, as individually tailored gene-treatments could help folks deal with chronic illnesses and genetic conditions (like cystic fibrosis, Huntington's disease, muscular dystrophy, and sickle cell), but also possibly help fight cancers and similar issues.More immediately, if this treatment is shown to be long-term efficacious for this first, baby patient, it could be applied to other patients who suffer the same deficiency, which afflicts an estimated 1 in 1.3 million people, globally. It's not common then—both parents have to have a mutant copy of a specific gene for their child to have this condition—but that's another reason this type of treatment is considered to be promising: many conditions aren't widespread enough to justify investment in pharmaceuticals or other medical interventions that would help them, so custom-tailored gene-editing could be used, instead, on a case-by-case basis.This is especially true if the speed at which a customized treatment can be developed is sped-up even further, though there are concerns about the future of this field and researchers' ability to up its efficiency as, at least in the US, the current administration's gutting of federal research bodies and funding looks likely to hit this space hard, and previous, similar victories that involved dramatically truncating otherwise ponderous developmental processes—like the historically rapid development of early COVID-19 vaccines—are not looked at favorably by a larger portion of the US electorate, which could mean those in charge of allocating resources and clearing the way for such research might instead pull even more funding and put more roadblocks in place, hobbling those future efforts, rather than the opposite.There are plenty of other researchers and institutions working on similar things around the world, of course, but this particular wing of that larger field may have higher hurdles to leap to get anything done in the coming years, if current trends continue.Again, though, however that larger context evolves, we're still in the early days of this, and there's a chance that this approach will turn out to be non-ideal for all sorts of reasons.The concept of tailored gene-editing therapies is an appealing one, though, as it could replace many existing pharmaceutical, surgical, and similar approaches to dealing with chronic, inherited conditions in particular, and because it could in theory at least allow us to address such issues rapidly, and without needing to mess around with the germ-line, because mutations could be assessed and addressed on a person-by-person basis, those edits staying within their bodies and not being passed on to their offspring, rather than attempting to make genetic customizations for future generations based on the imperfect knowledge and know-how of today's science, and the biased standards and priorities of today's cultural context.Show Noteshttps://www.nejm.org/doi/full/10.1056/NEJMoa2504747https://www.nih.gov/news-events/news-releases/infant-rare-incurable-disease-first-successfully-receive-personalized-gene-therapy-treatmenthttps://www.wired.com/story/a-baby-received-a-custom-crispr-treatment-in-record-time/https://www.wsj.com/tech/biotech/crispr-gene-editing-therapy-philadelphia-infant-8fc3a2c5https://www.washingtonpost.com/science/2025/05/15/crispr-gene-editing-breakthrough/https://www.npr.org/sections/shots-health-news/2025/05/15/nx-s1-5389620/gene-editing-treatment-crispr-inheritedhttps://interestingengineering.com/health/first-personalized-crispr-gene-therapyhttps://www.nature.com/articles/d41586-025-01496-zhttps://www.nytimes.com/2025/05/15/health/gene-editing-personalized-rare-disorders.htmlhttps://www.nytimes.com/2025/05/31/world/asia/us-science-cuts.htmlhttps://www.livescience.com/health/genetics/us-baby-receives-first-ever-customized-crispr-treatment-for-genetic-diseasehttps://en.wikipedia.org/wiki/He_Jiankui_affairhttps://en.wikipedia.org/wiki/CCR5https://en.wikipedia.org/wiki/Berlin_Patienthttps://en.wikipedia.org/wiki/CRISPR_gene_editinghttps://en.wikipedia.org/wiki/CRISPRhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6813942/ This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit letsknowthings.substack.com/subscribe

What happens when humans try to play God? The recent bombing of a fertility clinic in Southern California by an "anti-natalist" – someone opposed to human reproduction – reveals a disturbing philosophy gaining traction. These individuals believe bringing children into the world is fundamentally wrong, with many advocating for the eventual extinction of humanity.Behind this radical position lies a godless worldview where humans, not their Creator, determine the value of life. As Pastor Bob Fleischmann observes, "When people are godless, they become god themselves—they become the arbiters of right and wrong and who lives and who dies." This core insight connects seemingly disparate headlines we examine: from anti-natalism to a controversial Georgia case of a brain-dead pregnant woman kept on life support, to the miraculous development of a CRISPR-based treatment for an infant with a rare genetic disorder.Media bias features prominently in our discussion, particularly regarding ProPublica winning a Pulitzer Prize for reporting that allegedly linked pro-life laws to negative health outcomes—reporting our panel argues contained significant factual errors. This raises crucial questions about journalism as advocacy versus objective truth-seeking, and the responsibility Christians bear in consuming and sharing information critically.Throughout our conversation, the contrast becomes clear: worldviews centered on human autonomy inevitably create impossible burdens, placing responsibility for life-and-death decisions on individuals ill-equipped to bear them. Meanwhile, scientific breakthroughs like personalized genetic treatments demonstrate both human ingenuity and the temptation to cross ethical boundaries when God is removed from the equation.Have you noticed how difficult ethical decisions become when detached from a biblical framework? Join us as we navigate these complex waters and discover how faith provides the compass we desperately need in today's moral landscape. Share your thoughts or questions at lifechallengesus or email podcast@christianliferesources.com.SHOW NOTES:https://bit.ly/4mKarpShttps://bit.ly/43roBF2https://bit.ly/43HBtFXhttps://bit.ly/455FFBJFind strength and courage in your faith at this year's FEARLESS FAITH Conference. Inspired by Joshua 1:9, “Be strong and courageous,” join us for presentations on navigating life's storms, understanding God's peace, and engaging in crucial conversations about euthanasia, anorexia, abortion, prenatal genetic testing, and more. Hear powerful journeys of faith through loss and hope. Don't miss this empowering event! $50 in person or $40 virtual. Register now: https://christianliferesources.com/resources/events/2025-conference/Friar TimeThrough meaningful interviews and heartfelt conversations, Friar Time, hosted by Fr....Listen on: Apple Podcasts SpotifySupport the show

Men & Women's Wellbeing in the Age of TranshumanismWelcome to Take Your Power Back on Patriot TV Store, brought to you by Patriots Buying American! I'm your host, Kim Yeater, and I'm here with my co-host, Tammy Kelly. Today, we're tackling a critical topic: the decline of men's and women's wellbeing amidst transhumanism, low birth rates in the USA, and environmental toxins like heavy metals. These factors are disrupting men's testosterone levels and women's vaginal health, impacting vitality and quality of life. Transhumanism is the push to transcend human limits through technology—think AI implants, genetic editing, and synthetic biology. We're seeing it today in 2025 with advancements like Neuralink's brain-computer interfaces, CRISPR gene editing being used to alter human DNA, and the rise of biohacking to “upgrade” our bodies. But this movement often blurs the lines of what it means to be human—man and woman—replacing natural identity with a tech-driven, genderless ideal. This shift, combined with toxins lowering testosterone and disrupting vaginal microbiomes, is eroding our biological essence. That's why we're here to take our power back—reclaiming our God-given identities as men and women, not transhuman constructs. Patriots made.com/JJ is leading the charge, empowering patriots to reject big box stores and brands like Proctor & Gamble, Colgate, Palmolive, Johnson & Johnson, and Unilever, which use toxic ingredients like parabens, alcohols, sulfates, formaldehyde, and quaternary disinfectants. Instead, we're switching to our Patriots Made resources—named USA Today's Best Brand in 2025! This 40-year-old, family-owned, debt-free, and privately held manufacturer operates in 20 countries and over 2 million homes in the USA, providing everyday products that are better, safer, less expensive, and botanical, biodegradable, and bioavailable. That's the BIG difference! Visit PatriotsBuyingAmerican.com to take your masculine and feminine power back today.GIVE A THUMBS UP SUBSCRIBE & SHARE!!https://PatriotsBuying Americanhttps://PatriotTVBeef.comTo Support the Take Your Power Back Show & Keep Freedom Alive, go to: https://TakeYourPowerBackShow.comKim Yeater-Take Your Power Back Showhttps://KimYeater.com https://www.TakeYourPowerBackShow.com Rumble: https://rumble.com/c/TakeYourPowerBackShow Live Stream: https://rumble.com/TakeYourPowerBackShow/livePodcast Platforms: https://takeyourpowerbackshow.buzzsprout.com Patriot TV:  https://patriot.tv/take-your-power-back/  X @realkimyeaterFB kimberlyyeater & TakeyourpowerbackshowIG Takeyourpowerback_kimyeaterT takeyourpowerbackshowAll Media Inquiry here: TYPBProducer@gmail.comTake Our Border Backhttps://TakeOurBorderBack. Com https://rumble.com/c/TakeOurBorderBack Live Stream:  https://rumble.com/TakeOurBorderBack/live X @TobbconvoymainX @TobbconvoycaliforniaX @TobbconvoyarizonaX @TobbconvoytexasSend us a textSupport the show

Billionaire tech titan Elon Musk's time as a “special government employee” is coming to an end, but the DOGE team at the Defense Department will soon have greater influence on Pentagon contracting. Since President Donald Trump began his second term in January, Musk has spearheaded the Department of Government Efficiency's push across the federal government to find “waste, fraud and abuse,” slash certain types of spending and cut the workforce. A DOGE team was set up at the Pentagon — as well as other federal agencies — to implement those efforts. Musk wrote Wednesday night in a post on X that his time as a special government employee was coming to an end but: “The @DOGE mission will only strengthen over time as it becomes a way of life throughout the government.” In a sign that DOGE's influence will continue at the Pentagon, Secretary of Defense Pete Hegseth issued a new directive this week giving those personnel more oversight of contracting efforts. Hegseth wrote in a May 27 memo to senior Pentagon leadership, combatant commanders, and DOD agency and field activity directors that: “The Department of Defense (DoD) Department of Government Efficiency (DOGE) team will have the opportunity to provide input on all unclassified contracts. The Under Secretary of Defense for Acquisition and Sustainment (USD(A&S)), or its designee, will coordinate with DOGE to ensure that the opportunity for review of the Performance Work Statement/Statement of Work, accompanying estimates, deliverable descriptions, and requirements approval/validation documents, occurs when the requirements package is provided to a DoD contracting office to initiate a procurement or prior to the package being provided to a non-DoD assisting agency (e.g., General Services Administration).” In a video released Wednesday on X, Hegseth said the Pentagon had already saved more than $10 billion working with DOGE on previous efforts to review spending, including from a “line-by-line audit of over 50 contract vehicles.” Energy Secretary Chris Wright announced Thursday that the government would build a new supercomputer powered by NVIDIA chips and based at a department user facility at the Lawrence Berkeley National Laboratory. Officials said the supercomputer will be named Doudna after UC Berkeley scientist Jennifer Doudna, who co-invented CRISPR gene editing technology and won the Nobel Prize back in 2020. The Doudna supercomputer, which is geared toward high-performance computing and training artificial intelligence technology, will be based at the National Energy Research Scientific Computing Center. It is only the latest Energy Department project designed for the AI age: El Capitan, a supercomputer based at Lawrence Livermore National Laboratory and currently the world's fastest, is also designed with machine learning in mind, as is Frontier, a DOE supercomputer housed at the Oak Ridge National Laboratory in Tennessee. A spokesperson would not comment further on how the Doudna supercomputer's speeds might compare to other systems. Government supercomputing projects, including those focused on AI, are now supported by the same national laboratory system that incubated the Manhattan Project, which produced the world's first atomic weapons. The Daily Scoop Podcast is available every Monday-Friday afternoon. If you want to hear more of the latest from Washington, subscribe to The Daily Scoop Podcast  on Apple Podcasts, Soundcloud, Spotify and YouTube.

Episode 9: The Future of Survival – The Genetic Engineering Revolution Episode Description In this episode of The Future of Survival, we explore the rapidly accelerating world of genetic engineering. From CRISPR-edited crops and lab-grown organs to designer babies and enhanced humans, gene editing could change everything about survival. But are preppers ready to embrace a future where survival might be decided by your DNA? We break down the science, the ethical dilemmas, and how to prepare for a biotech-driven world. Episode Breakdown

Featuring Dave Beverley Sr (Jesus Freak Computer Geek), Pete Ohlinger (Days of Noah Podcast), & Dr. Alphonzo Monzo (DrMonzo.com)Join host Rod Smith on the Millennial Mustard Seed Podcast for a riveting exploration into how cutting-edge science and technology intersect with the spiritual realm. In this episode, our distinguished panel dives into the transformative worlds of CRISPR gene editing, Computational Bio, Energy Harvesting Beast Tech, W-Band, and self healing nephilim nano tech are just a few of the wild discussion points on this part two roundtable episode. share this one far and wide friends!Explore the possibility that modern science and technology are playing an unforeseen role in the cosmic battle between light and darkness.• Panel Perspectives: Hear from Dave Beverley Sr, Pete Ohlinger, and Dr. Alphonzo Monzo as they blend scientific insight with a biblical lens, challenging conventional narratives and inspiring deeper faith in Christ.• Plant a seed in time of need: ⁠⁠https://creators.spotify.com/pod/show/rodney-jay/subscribe⁠⁠• Email Rod Smith:⁠⁠⁠mmseed@proton.me⁠⁠⁠ Partner with Our Ministry: Consider supporting and partnering with us as we spread the Gospel through innovative media.• Buy a Copy of My New Book!⁠⁠ https://a.co/d/3Gf5sqK⁠⁠• Venmo:⁠⁠⁠@Rodney-Smith-368⁠⁠⁠• PayPal:⁠⁠⁠@creative775⁠⁠• Cash App:⁠⁠⁠$Rodsworth77⁠⁠⁠

"Every technology has a shelf life. It's just true, right? And, so, is that shelf life years? Is it months? Is it weeks? Is it days? You know, has it actually already been surpassed? That's just progress, right? That's great” In this episode, Johnny Hu, Principal at Menlo Ventures, unpacks his journey through neuroscience research at Genentech and Cambridge, the electrifying early days of CRISPR, and the fast-moving Boston biotech scene, revealing how academic culture, tool-building, and intentional company culture fuel breakthrough innovation. He offers a candid look at bridging academia and industry, the realities of risk and execution in biotech startups, and the collaborative and competitive dynamics of venture investing—showing what it really takes to thrive where science, startups, and investment meet.

Epicrispr Biotechnologies is using CRISPR to modulate the expression of disease-causing genes without making cuts to DNA. Its lead program is in development to treat FSHD, a genetic disorder that causes progressive weakness in the muscles of the face, shoulders, and upper arms. We spoke to Amber Salzman, CEO of Epicrispr, about how its one-and-done therapies work to target the epigenome, the company's lead program in FSHD, and the broader applications for its therapeutic approach.

Byron Goo, CEO of Tea Chest Hawaiʻi, talks about how tariffs are affecting the tea trade; Jennifer Doudna, Nobel Laureate in Chemistry, discusses developments in gene-editing with CRISPR

Welcome back to another eye-opening episode of Ditch the Lab Coat with Dr. Mark Bonta! While we usually dig into the science behind medicine's biggest questions, on this episode, Dr. Mark is joined by the extraordinary Dr. Erwin Loh — a powerhouse at the intersection of medicine, law, healthcare leadership, and medical futurology. Dr. Loh is not only the President of the Royal Australasian College of Medical Administrators and National Director of Medical Services for Calvary Healthcare in Australia, but he's also a trusted voice on LinkedIn, where he untangles medical breakthroughs and ethical dilemmas for his global audience on the daily (sometimes 5 to 10 times a day!)—all while juggling life as an executive and dad.Together, Mark and Erwin tackle some of the most pressing—and headline-worthy—topics in medicine today. They dig into Long Covid: what it is, why it's not just "all in your head," and why the recognition of this condition is also reshaping how we think about elusive illnesses like chronic fatigue syndrome and fibromyalgia. If you've wondered what's really happening with the mysterious gut microbiome, the resurgence of old viruses, or the risks of misinformation in today's media chaos, you'll find answers grounded in the latest evidence, not just the loudest opinions.But that's not all—they venture into the weird and wild wonders of scientific progress, from the looming issue of plastics in our cells to CRISPR gene editing and the promises (and perils) of AI in healthcare. Along the way, you'll hear why microplastics might be the “asbestos of our age,” how mixing vaccines can make you a lightning rod for online trolls, and why being cautiously optimistic about humanity's next steps—despite climate change, pandemics, and deepfake bioweapons—is not just reasonable, it's necessary.Whether you're a science junkie, a future-watcher, or simply want a hopeful, no-nonsense take on where medicine is headed (and how it affects your life), this episode delivers smart, ethical, and accessible conversation. Pour yourself something strong, turn your curiosity up to eleven, and get ready for a tour de force of myth-busting, insight, and inspiring optimism from two voices at the cutting edge of healthcare.Tune in for the kind of honest, evidence-based, and thought-provoking discussion you won't find anywhere else—right here on Ditch the Lab Coat!Dr Loh's Links( https://www.linkedin.com/in/erwinloh/ )( https://x.com/erwinloh )Episode HighlightsLong Covid: Real and Varied Long Covid is a legitimate, multifaceted syndrome. Most cases improve within two years, but symptoms and underlying mechanisms differ widely.Post-Viral Syndromes Aren't New Long-term illness after viral infections, like after influenza or Epstein Barr, has long existed—Covid just spotlighted this issue.Chronic Illness Recognition Grows Long Covid research is giving more credibility to conditions like chronic fatigue syndrome and fibromyalgia within the medical community.Silent Illnesses Challenge Healthcare Illnesses without definitive biomarkers, such as Long Covid, are harder to diagnose and treat, often leading to patient stigma.Microbiome's Expanding Influence Our gut, skin, and oral microbiomes profoundly affect physical and mental health, though much remains to be discovered about exactly how.Viruses and Chronic Disease Links Viruses may contribute to diseases like multiple sclerosis, cancers, and possibly Alzheimer's, highlighting new frontiers in research.Gene Editing: Transformative Power CRISPR technology lets us precisely edit human genes, promising cures for some diseases but raising major ethical and safety concerns.AI: Double-Edged Healthcare Tool AI accelerates medical discovery and innovation but can also enable harmful outcomes, including creation of bioweapons or misinformation.Plastics: Ubiquitous Unknown Threat Microplastics are everywhere, even in our cells. The true health risks are not fully understood but raise serious environmental and biological questions.Episode Timestamps4:22 – Long Covid: Global Challenge and Uncertainty9:31 – Recognizing Long Covid's Impact10:47 – Exploring Long Covid Treatments16:39 – Unknown Frontiers in Science18:22 – Understanding Microbiome and Disease Dynamics21:04 – COVID Vaccination Journey and Hybrid Immunity24:42 – LinkedIn: Fewer Trolls, Richer Conversations29:04 – Gene Therapy via Phage Infections31:58 – Genetic Correction: Hope and Ethics36:54 – AI and Humanity's Existential Challenges41:14 – Future of Microplastics and Society44:24 – AI, Cognition, and Future Governance46:28 – "Medical Futurology with Irwin Lowe48:31 – "AI in Medicine: Trust MattersDISCLAMER >>>>>>    The Ditch Lab Coat podcast serves solely for general informational purposes and does not serve as a substitute for professional medical services such as medicine or nursing. It does not establish a doctor/patient relationship, and the use of information from the podcast or linked materials is at the user's own risk. The content does not aim to replace professional medical advice, diagnosis, or treatment, and users should promptly seek guidance from healthcare professionals for any medical conditions.   >>>>>> The expressed opinions belong solely to the hosts and guests, and they do not necessarily reflect the views or opinions of the Hospitals, Clinics, Universities, or any other organization associated with the host or guests.    Disclosures: Ditch The Lab Coat podcast is produced by (Podkind.co) and is independent of Dr. Bonta's teaching and research roles at McMaster University, Temerty Faculty of Medicine and Queens University. 

In today's episode, we trace a record-speed rescue of an infant using CRISPR gene editing and weigh the growing calls to freeze the very science that pulled it off.

What happens when scientific advancement outpaces our ethical frameworks? As Christian Life Resources celebrates 42 years of ministry, this compelling discussion explores how a once primarily pro-life organization evolved to address the complex moral questions of our time and prepare for what's ahead.The conversation takes us from CLR's humble beginnings—marked by a watershed moment when U.S. Surgeon General C. Everett Koop spoke at their 1984 convention—to today's expanded mission addressing everything from surrogate parenting to end-of-life care. National Director Bob Fleischmann candidly shares how the organization matured from focusing solely on fetal development arguments to helping Christians navigate ethical dilemmas through a biblical lens.Looking forward, three critical frontiers demand our attention: revolutionary procreation technologies including artificial wombs, CRISPR gene editing that blurs the line between healing and enhancement, and artificial intelligence that's reshaping human interaction. These advancements arrive amid deepening social fragmentation, where truth increasingly becomes whatever opinion garners the most likes.Yet amidst these challenges, CLR maintains unwavering hope grounded in Scripture. The organization is preparing for the future with exciting initiatives: succession planning for leadership transition, a comprehensive "Debunk" series addressing common misconceptions about life issues, an AI-enhanced website launching this fall, and expansion of their New Beginnings - A Home for Mothers and elder care ministries.Have questions about navigating today's complex ethical landscape from a Christian perspective? Visit lifechallenges.us to explore our resources or contact us directly. Remember, while the challenges change, our foundation remains the same: honoring and glorifying God in all we do.SHOW NOTES:Find strength and courage in your faith at this year's FEARLESS FAITH Conference. Inspired by Joshua 1:9, “Be strong and courageous,” join us for presentations on navigating life's storms, understanding God's peace, and engaging in crucial conversations about euthanasia, anorexia, abortion, prenatal genetic testing, and more. Hear powerful journeys of faith through loss and hope. Don't miss this empowering event! $50 in person or $40 virtual. Register now: https://christianliferesources.com/resources/events/2025-conference/Friar TimeThrough meaningful interviews and heartfelt conversations, Friar Time, hosted by Fr....Listen on: Apple Podcasts SpotifySupport the show

My guest is Dr. Melissa Ilardo, Ph.D., professor of biomedical informatics at the University of Utah. We discuss the interplay between genes and behaviors, including how certain behaviors can improve resilience by changing gene and organ function, as well as natural selection events happening in humans today. We also discuss the immune system–related reasons people find the smells of potential mates attractive—or not. We explore how physical and psychological traits are passed from one generation to the next, and the specific behaviors that can influence gene expression to improve health and performance. Melissa explains her lab's pioneering research on breath-hold training and how activation of the dive reflex through breath holding can significantly improve oxygen availability by changing spleen size and function. We also delve into the medical uses and ethics of gene editing to cure disease in both babies and adults. For those interested in genes and inheritance, human performance, immune system function, and natural selection, this episode illustrates the remarkable interplay between human nature and nurture. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Melissa Ilardo 00:02:35 Nature vs Nurture, Gene Expression, Eye Color 00:07:06 Sponsors: Joovv & Eight Sleep 00:10:24 Epigenetics, Trauma, Mutations; Hybrid Vigor, Mate Attraction 00:15:47 Globalization; Homo Sapiens, Mating & Evolution; Mutations 00:25:28 Sea Nomads, Bajau & Moken Groups; Free Diving, Dangers & Gasp Reflex 00:32:52 Cultural Traditions, Free Diving & Families; Fishing 00:35:36 Mammalian Dive Reflex, Oxygen, Spleen, Cold Water & Face; Exercise 00:42:43 Sponsors: AG1 & LMNT 00:46:00 Free Diving, Spleen, Thyroid Hormone, Performance Enhancement 00:52:00 Dive Reflex, Immune System; Swimming & Health; Coastal Regions & Genetics 00:55:17 Female Free Divers, Haenyeo, Cold Water, Age, Protein 01:03:20 Human Evolution & Diet, Lactase, Fat 01:05:07 Korean Female Free Divers & Adaptations, Cardiovascular, Pregnancy 01:10:13 Miscarriages & Genetic Selection; Bajau, External Appearance, Mate Selection 01:17:15 Sponsor: Function 01:19:03 Free Diving, Underwater Vision; Super-Performers & Genetics 01:25:01 Cognitive Performance, Autism, Creativity; Genetic Determinism & Mindset 01:36:30 Genetics & Ethics, CRISPR, Embryo Genetic Screening 01:44:36 Admixture, Genetics; Are Humans a Single Species? 01:49:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Topics discussed on this episode include the benefits of marriage, David Hogg getting the axe, California taking a soft stance on child trafficking, the best frozen pizza, an American basketball player arrested in Indonesia, NFL Draft grades, the NBA Playoffs, genetically modified babies, a robot who attacked its handlers, what David Duchovny thinks about conspiracy theories, and the fantastic story of Indrid Cold.

Broadcast from KSQD, Santa Cruz on 5-22-2025: Dr. Dawn explores groundbreaking cancer research using high-throughput "digital twin" analysis to reverse colon cancer cells back to normal states, identifying three master molecular switches that can induce normal cell differentiation without killing the cancer cells, thus avoiding traditional chemotherapy side effects. She discusses remarkable results from Memorial Sloan Kettering showing 80% of patients with mismatch repair deficient tumors, including all 49 rectal cancer patients, saw complete tumor disappearance after six months of dostarlimab immunotherapy, with no recurrence at five years and minimal side effects. The program covers innovative CRISPR applications, including targeting previously "undruggable" cancer mutations like KRAS and BRAF by selectively degrading mutant RNA messages while preserving healthy genes, offering unprecedented precision in cancer treatment. Dr. Dawn explains a clever immunotherapy approach that disguises tumors as pig organs using Newcastle disease virus carrying alpha-gal enzyme, tricking the immune system into mounting fierce attacks against cancer cells, showing promising results in both monkey and human trials. She describes fascinating research using cryoshocked tumor cells as Trojan horses, where liquid nitrogen-treated cancer cells carrying CRISPR gene editing tools directly seek out tumors, offering superior targeting compared to injecting CRISPR. The show reveals how cancers create protective acid walls around themselves to repel immune cells, with individual cancer cells pumping lactic acid away from the tumor center to form pH 5.3 barriers that kill attacking CD8 T cells within hours. Dr. Dawn discusses breakthrough mRNA cancer vaccines for glioblastoma using patients' own tumor cells, showing rapid immune system activation within 48 hours and extending survival in both dogs and humans with this aggressive brain cancer. She explores the "flower code" mechanism where cancer cells gaslight healthy cells through epigenetic manipulation, expressing dominant "flower win" codes to overpower normal cells expressing "flower lose" codes in biological turf wars. The program addresses systemic problems in cancer classification, explaining how organ-based categorization delays access to effective treatments, with patients waiting years for drugs that could help based on molecular profiles rather than tumor location. Dr. Dawn concludes by highlighting medical discrimination against people with Duffy null phenotype, primarily affecting African Americans, whose naturally lower neutrophil counts lead to reduced chemotherapy doses and excluded clinical trial participation despite no increased infection risk.

In this episode, Jason chats with David Friedberg—CEO of Ohalo Genetics and co-host of the All-In Podcast—about how AI is transforming agriculture and startups. David introduces Ohalo's "Boosted Breeding" technology, which enables plants to inherit 100% of genes from both parents, potentially doubling crop yields. They also discuss building AI-first companies, genome language models, and the future of creativity in an AI-driven world.*Timestamps:(0:00) David Friedberg joins Jason to discuss AI Basics.(1:44) How AI leveled up hiring and operations at startups(5:46) AI and economic opportunities, complex problem-solving, and leadership's role(11:48) How to build an AI-first company culture(16:48) AI's transformative impact on biology and DNA sequencing(21:36) The “GLM” - GPT for DNA Is already in production(23:17) Biology meets AI: designing perfect plants with CRISPR and genome models(32:08) Is the “Age of Abundance” around the corner?(35:56) Democratization of creativity through AI: personalized Star Wars musicals & the future of media*Uncover more valuable insights from AI leaders in Google Cloud's 'Future of AI: Perspectives for Startups' report. Discover what 23 AI industry leaders think about the future of AI—and how it impacts your business. Read their perspectives here: https://goo.gle/futureofai*Check out all of the Startup Basics episodes here: https://thisweekinstartups.com/basicsCheck out Google Cloud: https://cloud.google.com/Check out Ohalo: https://www.ohalo.com/*Follow David:X: https://x.com/friedbergLinkedIn: https://www.linkedin.com/in/davidfriedberg/*Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanis*Follow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

00:03:50 - 00:18:12Trump's $175 billion Golden Dome missile defense system aims to use space-based interceptors to counter advanced missiles, but China warns it risks militarizing space and sparking an arms race. Congress estimates costs at $500 billion over 20 years. Russia's nuclear-powered Burevestnik missile, with unlimited range, could render it obsolete, raising concerns about budget overruns and SpaceX's involvement. 00:18:36 - 00:26:10Neocons push for war with Iran, demanding its nuclear program's dismantlement, while MAGA influencers like Bannon and Greene favor diplomacy. This reflects public exhaustion with Middle East wars, opposing defense contractors' agendas, with the host noting a hopeful shift against escalation. 00:31:12 - 00:38:12The Pentagon, citing unverified Chinese “super soldier” claims, proposes genetic experiments on U.S. troops using CRISPR and mRNA, alongside biosurveillance. Ethical concerns arise over human experimentation and CIA ties, with deregulation favoring biotech firms, risking taxpayer funds and safety. 00:44:45 - 00:53:36Trump grants asylum to 54 Afrikaner South Africans facing violence and land confiscation, confronting Ramaphosa with evidence of “white genocide.” The host supports this, criticizing media deflections and narrow refugee definitions, emphasizing the severe persecution Afrikaners endure. 01:17:37 - 01:36:07The FDA now requires trials for COVID-19 vaccines for healthy people aged 6 months to 64, but approved high-risk group vaccines without data, rushed by Trump's “warp speed.” A Senate report reveals Biden officials hid myocarditis risks in young men, delaying warnings despite early signals, driven by corporate interests. Low vaccine uptake (13% kids, 23% adults) and rising heart issues highlight the cover-up. 01:36:07 - 01:40:50Medpage Today confirms RFK Jr.'s claim that the MMR mumps vaccine is ineffective, admitting Merck's fraudulent data, but dismisses him as a lawyer. Failed lawsuits left untested, harmful vaccines on the market, with one-third of trial kids facing health issues, exposing systemic vaccine regulation flaws. 01:48:10 - 02:01:35A bill strips states' AI regulation rights for 10 years, a Trump-backed federal power grab seen as unconstitutional. States urged to block AI infrastructure. Vermont pauses its EV mandate, citing weak tech and infrastructure, resisting California's 2035 EV push, which could set a national standard. 02:04:03 - 02:08:48Rep. Luna's bill seeks to repeal the Patriot Act, blamed for post-9/11 surveillance and rights violations. The host sees 9/11 as a pretext for wars and a police state, urging the act's end to curb intelligence agency abuses and restore privacy. 02:10:21 - 02:34:23Cecile Richards, dead at 67 from brain cancer, is condemned for leading 3.5 million abortions at Planned Parenthood and alleged fetal part sales. Her unrepentant stance, Freedom from Religion awards, and Biden's Medal of Freedom are criticized as anti-God. Kushner's 2017 funding offer was rejected. Abortion's 2024 toll (45.1 million, 42% of deaths) and 60% of African American deaths are called “black genocide.” GOP's funding via CARES Act ($80 million) and MAGA's defense of Trump's vaccines are slammed. 02:37:05 - 02:49:03Brown Foods' “Unreal Milk” and Israeli lab-grown dairy, like Wilk, claim to cut emissions by 82%, backed by Gates and USDA despite no farming. Biomilq targets infants, tied to C40's no-dairy push. Called “tumor milk,” it's criticized as an anti-agriculture, climate-driven scam with lax FDA oversight. 02:50:39 - 03:00:36Trump's “Gold Card” visa, costing $5 million, claims 250,000 applicants to raise $1 trillion, but only 277,000 global millionaires qualify. Offering tax-free foreign income and no country caps, it's decried as a corrupt deal for Trump's allies, bypassing vetting and America-first values.Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.

00:03:50 - 00:18:12Trump's $175 billion Golden Dome missile defense system aims to use space-based interceptors to counter advanced missiles, but China warns it risks militarizing space and sparking an arms race. Congress estimates costs at $500 billion over 20 years. Russia's nuclear-powered Burevestnik missile, with unlimited range, could render it obsolete, raising concerns about budget overruns and SpaceX's involvement. 00:18:36 - 00:26:10Neocons push for war with Iran, demanding its nuclear program's dismantlement, while MAGA influencers like Bannon and Greene favor diplomacy. This reflects public exhaustion with Middle East wars, opposing defense contractors' agendas, with the host noting a hopeful shift against escalation. 00:31:12 - 00:38:12The Pentagon, citing unverified Chinese “super soldier” claims, proposes genetic experiments on U.S. troops using CRISPR and mRNA, alongside biosurveillance. Ethical concerns arise over human experimentation and CIA ties, with deregulation favoring biotech firms, risking taxpayer funds and safety. 00:44:45 - 00:53:36Trump grants asylum to 54 Afrikaner South Africans facing violence and land confiscation, confronting Ramaphosa with evidence of “white genocide.” The host supports this, criticizing media deflections and narrow refugee definitions, emphasizing the severe persecution Afrikaners endure. 01:17:37 - 01:36:07The FDA now requires trials for COVID-19 vaccines for healthy people aged 6 months to 64, but approved high-risk group vaccines without data, rushed by Trump's “warp speed.” A Senate report reveals Biden officials hid myocarditis risks in young men, delaying warnings despite early signals, driven by corporate interests. Low vaccine uptake (13% kids, 23% adults) and rising heart issues highlight the cover-up. 01:36:07 - 01:40:50Medpage Today confirms RFK Jr.'s claim that the MMR mumps vaccine is ineffective, admitting Merck's fraudulent data, but dismisses him as a lawyer. Failed lawsuits left untested, harmful vaccines on the market, with one-third of trial kids facing health issues, exposing systemic vaccine regulation flaws. 01:48:10 - 02:01:35A bill strips states' AI regulation rights for 10 years, a Trump-backed federal power grab seen as unconstitutional. States urged to block AI infrastructure. Vermont pauses its EV mandate, citing weak tech and infrastructure, resisting California's 2035 EV push, which could set a national standard. 02:04:03 - 02:08:48Rep. Luna's bill seeks to repeal the Patriot Act, blamed for post-9/11 surveillance and rights violations. The host sees 9/11 as a pretext for wars and a police state, urging the act's end to curb intelligence agency abuses and restore privacy. 02:10:21 - 02:34:23Cecile Richards, dead at 67 from brain cancer, is condemned for leading 3.5 million abortions at Planned Parenthood and alleged fetal part sales. Her unrepentant stance, Freedom from Religion awards, and Biden's Medal of Freedom are criticized as anti-God. Kushner's 2017 funding offer was rejected. Abortion's 2024 toll (45.1 million, 42% of deaths) and 60% of African American deaths are called “black genocide.” GOP's funding via CARES Act ($80 million) and MAGA's defense of Trump's vaccines are slammed. 02:37:05 - 02:49:03Brown Foods' “Unreal Milk” and Israeli lab-grown dairy, like Wilk, claim to cut emissions by 82%, backed by Gates and USDA despite no farming. Biomilq targets infants, tied to C40's no-dairy push. Called “tumor milk,” it's criticized as an anti-agriculture, climate-driven scam with lax FDA oversight. 02:50:39 - 03:00:36Trump's “Gold Card” visa, costing $5 million, claims 250,000 applicants to raise $1 trillion, but only 277,000 global millionaires qualify. Offering tax-free foreign income and no country caps, it's decried as a corrupt deal for Trump's allies, bypassing vetting and America-first values.Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.

In this episode of the Epigenetics Podcast, we talked with Ani Deshpande from Sanford Burnham Prebys about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. Throughout our discussion, we delve into Dr. Despande's journey into the field of biology and science, tracing his evolution from a literature enthusiast in Mumbai to a dedicated cancer researcher. He reflects on his formative experiences during his PhD at Ludwig Maximilian University in Munich, where she developed murine models for refractory acute myeloid leukemia (AML). We examine these models' contributions to therapeutic discovery and understanding the intricate mechanisms underscoring AML's complexities. Transitioning to his postdoctoral work at Scott Armstrong's lab in Boston, Dr. Despande shares his insights on the importance of epigenetic regulators, such as DOT1L, in leukemias, and how they can serve as strategic therapeutic targets. His ambitious pursuit of translational research is further highlighted through his efforts in developing a conditional knockout mouse model and his collaborative work utilizing CRISPR technology to refine our understanding of epigenetic regulation in cancer pathogenesis. Moreover, we engage in a conversation about the challenges and opportunities that arise when establishing his lab at Sanford Burnham Prebys. Dr. Despande candidly discusses the delicate balance between pursuing topics of genuine interest versus adhering to grant fundability, underlining the tension researchers face in the current scientific landscape. His emphasis on the critical need for innovation within lab settings serves as a motivational call for emerging scientists to venture beyond the established templates that often inhibit groundbreaking discoveries. We conclude our dialogue with an exploration of his recent projects, which involve targeting specific epigenetic modifiers and how his lab's findings can contribute to greater understanding and potential treatments for not only AML but also other pediatric cancers driven by gene fusions. Dr. Despande's insights into the integration of modern technologies, such as CRISPR libraries, exemplify his commitment to pushing the boundaries of cancer research. In addition to discussing his scientific contributions, we touch upon Dr. Despande's foray into podcasting (The Discovery Dialogues), shedding light on his motivation to bridge the communication gap between scientists and the broader public. He articulates his desire to demystify scientific discoveries and promote awareness about the intricate journey of research that lays the groundwork for medical advancements. This multidimensional discussion not only highlights his scientific achievements but also emphasizes the importance of effective science communication in fostering public understanding and appreciation of research.   References Deshpande AJ, Cusan M, Rawat VP, Reuter H, Krause A, Pott C, Quintanilla-Martinez L, Kakadia P, Kuchenbauer F, Ahmed F, Delabesse E, Hahn M, Lichter P, Kneba M, Hiddemann W, Macintyre E, Mecucci C, Ludwig WD, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006 Nov;10(5):363-74. doi: 10.1016/j.ccr.2006.08.023. PMID: 17097559. Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20. PMID: 25464900; PMCID: PMC4291116. Sinha S, Barbosa K, Cheng K, Leiserson MDM, Jain P, Deshpande A, Wilson DM 3rd, Ryan BM, Luo J, Ronai ZA, Lee JS, Deshpande AJ, Ruppin E. A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing. Nat Commun. 2021 Nov 11;12(1):6512. doi: 10.1038/s41467-021-26788-6. Erratum in: Nat Commun. 2022 May 16;13(1):2828. doi: 10.1038/s41467-022-30475-5. PMID: 34764240; PMCID: PMC8586238.   Related Episodes Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

00:45 Treating mosquitoes for malariaResearchers have developed two compounds that can kill malaria-causing parasites within mosquitoes, an approach they hope could help reduce transmission of the disease. The team showed that these compounds can be embedded into the plastics used to make bed nets, providing an alternative to insecticide-based malaria-control measures, which are losing efficacy in the face of increased resistance.Research article: Probst et al.10:42 Research HighlightsThe sunlight-powered device that can harvest drinkable water from desert air, and evidence that the world's richest people are disproportionately responsible for climate impacts.Research Highlight: Atacama sunshine helps to pull water from thin airResearch Highlight: The world's richest people have an outsized role in climate extremes13:02 The genetics that can lead to pregnancy lossResearchers have found specific genetic mutations that can lead to pregnancy loss. It's known that errors, such as the duplication of chromosomes, can lead to nonviable pregnancies but less has been known about non-chromosomal genetic errors. The new work identifies DNA sequence changes that can lead to a non-viable pregnancy. This may offer clinicians the ability to screen embryos for these changes to help avoid pregnancy loss.Research article: Arnadottir et al.22:24 Briefing ChatBespoke CRISPR-based therapy treats baby boy with devastating genetic disease, and the ‘anti-spice' compounds that can lower chillies' heat.Nature: World's first personalized CRISPR therapy given to baby with genetic diseaseNew Scientist: Chemists discover 'anti-spice' that could make chilli peppers less hotSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Tomatoes come in all kinds of colors, sizes, and flavors. But what's going on at the genetic level? What makes a tomato red or yellow? Tiny or giant?Researchers are mapping the genomes of 22 varieties of nightshades—the family of plants that includes tomatoes, potatoes, and eggplants. They located the genes that control the size of tomatoes and eggplants and then used CRISPR gene editing to grow bigger fruits without sacrificing flavor.Geneticist Michael Schatz joins Host Ira Flatow to talk about his latest research into nightshade genomes and the current state of genetically modified crops.Guest: Dr. Michael Schatz, professor of computational biology and oncology at Johns Hopkins University, based in Baltimore, Maryland.Transcript will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

BestPodcastintheMetaverse.com Canary Cry News Talk #842 - 05.19.2025 - Recorded Live to 1s and 0s CRISPR BABY USA | Comey Calculus, Harry Legs Drama, Nephilim Update Deconstructing World Events from a Biblical Worldview Declaring Jesus as Lord amidst the Fifth Generation War! CageRattlerCoffee.com SD/TC email Ike for discount   Join the Canary Cry Roundtable This Episode was Produced By:   Executive Producers Sir LX Protocol V2 Baron of the Berrean Protocol*** Sir Jamey Not the Lanister***   Producers of TREASURE (CanaryCry.Support) Sir Darrin Knight of the Hungry Panda's, Julie S, Joel, Aaron B, American Hobo, Cage Rattler Coffee, Lane, Anonymous, Sir Morv Knight of the Burning Chariots   Producers of TALENT JOLMS, Sir Thorsteen, Sir Ike, Samurai Princess   Producers of TIME Timestampers: Jade Bouncerson, Morgan E Clippy Team: Courtney S, JOLMS, Kristen Reminders: Clankoniphius Links: JAM   SHOW NOTES/TIMESTAMPS HELLO WORLD 0:26 EFNO   FBI 1:14 →Trump says Comey called for ‘assassination of the president' with '8647′ Instagram post (CNBC) SHILLZILLA Clip: ‘It's So Dumb': Chris Cillizza Unloads On Comey Over Post (Daily Caller) → EPSTEIN Clip: Patel and Bongino say Epstein killed himself “I've seen the whole file”   EXECS 30:42   HARRY LEGS JOE 43:13 Exclusive: Prosecutor's audio shows Biden's memory lapses (Axios) → Joe Biden diagnosed with 'aggressive' prostate cancer (BBC) Biden posts about cancer (X) Joe biden Gaffe Cancer 2022 (X)   CRISPR 56:10 A Baby Received a Custom Crispr Treatment in Record Time (Wired) Dr. He's Wife (X)   AI 1:38:34 Ai will double human lifespan by 2030 (Pop Mechanics)   PRODUCERS 1:39:55   NEPHILIM UPDATE 1:56:42 The otherworldly story of goth mystics Fields Of The Nephilim (Louder Sound)   PRODUCERS 2:17:44   TALENT/MEET UP 2:17:57 TIME/END 2:37:44

Sunday May 18, 2025. Week 21   Show notes on the site: https://curesyngap1.org/podcasts/syngap10/    CAMP4 Press Release https://investors.camp4tx.com/news-releases/news-release-details/camp4-presents-translational-data-syngap1-related-disorders Dr. Yuri at WODC: https://www.youtube.com/watch?v=oNwgo7TmrVo Presentation at ASGCT: https://investors.camp4tx.com/news-events/presentations GETA Talk: https://www.facebook.com/Syngapresearch/posts/pfbid08Aztex32vdwNZduVkPQeG353W49Dhq8iKJeZEkajKUmkeUiDdCwzyqa9ndEVpdCUl    To get these Therapies to kids the NHS data is key, ProMMis CHOP - Email them ENDD@chop.edu Stanford (Singed!) - https://curesyngap1.org/blog/srf-announces-stanford-launches-california-synaptopathy-clinic/ CHCO - https://curesyngap1.org/blog/visiting-syngap1-natural-history-study-childrens-hospital-colorado-chco/ Citizen Health https://cureSYNGAP1.org/Citizen is at 267, why not 300?   Hopkins article featuring SRF - Competition is good for the patient FB https://www.facebook.com/cureSYNGAP1/posts/pfbid07MP7St3zdxLKYXTJULKa5S35YvgL6AJndenHicedxU3rtQF6iY1wwwNUoDuUD9cpl LI https://www.linkedin.com/posts/curesyngap1_nih-cuts-stalling-progress-on-rare-genetic-activity-7328449817074946048-AAsB   ASGCT Mouse poster for Q504X from the JAX, Dr. Matt Simon Conf Video https://www.youtube.com/watch?v=loYXkkTSUIY  Presentation on AAV for SYNGAP1 at Allen by Dr. Megan Quinlan   What about this guy? Gift link: https://www.nytimes.com/2025/05/15/health/gene-editing-personalized-rare-disorders.html?unlocked_article_code=1.H08.E-oX.t5bo6kxJGUOU&smid=url-share  PBS: https://www.youtube.com/watch?v=dOeiPoa3gvM Eric Topol: https://erictopol.substack.com/p/the-first-human-to-undergo-in-vivo   More incredible news https://news.unl.edu/article/husker-team-wins-second-round-prize-in-nih-gene-editing-challenge   REPURPOSING Mike's post in private SRF Group: https://www.facebook.com/groups/syngap #Amlexanox with Fortuity Pharma. https://fortuitypharma.com/    Butyrate Update https://aesnet.org/abstractslisting/phenylbutyrate-for-syngap1-related-developmental-and-epileptic-encephalopathy Trial ending at year end, working with SLC6A1 and Rachel Heilmann to continue coverage, then we can scale, once we have a paper. SunButyrate https://a.co/d/7kiHXS8    PUBMED  328 total with 20 YTD https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&sort=date&sort_order=asc&timeline=expanded Sleep https://www.sciencedirect.com/science/article/abs/pii/S1389945724005793?via%3Dihub   SRF Fundraisers MDBR with AJH and HM https://curesyngap1.org/calendar/million-dollar-bike-ride-2025/   Well done to Tavilla and Jones!  We are over $221k Tavilla clears $160k for Sprint. https://donate.curesyngap1.org/campaign/sprint4syngap2025/c660255   Porter Jones and his friends William, Patrick, and Judson raised over $10k in doughnuts, this netted over $8k because people donated.  Amazing and thank you to Krispy Kreme.  https://donate.curesyngap1.org/event/sweets-for-syngap1/e678677   SRF PROFILES Vicky post in Mexico https://www.linkedin.com/posts/victoria-arteaga-26913433_diagnostico-epilepsia-syngap1-activity-7329725268003069953-R41P Vicky's Siblings Violeta and Lourdes, sisters to Amelia https://curesyngap1.org/syngap-siblings/ Harper Albrecht Wednesday Warrior #215 parents Ashley and Justin https://cureSYNGAP1.org/Warrior   PREREGISTER FOR THE CURE SYNGAP1 CONFERENCE https://curesyngap1.org/calendar/cure-syngap1-conference-2025-hosted-by-srf/

In this episode, we discuss the anti-aging effects of therapeutic plasma exchange (TPE) with Dr. Irina Conboy, a professor in the Department of Bioengineering at UC Berkeley. Her current research focuses on unraveling the key signal transduction pathways that regulate adult stem cell behavior – and understanding how these pathways change with age… From synthetic biology to CRISPR technologies, Dr. Conboy has been working in the fields of aging and genetic diseases for decades. Is aging a disease that can be solved? If so, what role does TPE play in it? If you're interested in the mysterious topic of human aging, this podcast is undoubtedly for you! Jump in to find out: What TPE is, and what it's used for.  The benefits of “rebooting” blood signal proteins. What blood plasma is, and how it is produced in the human body. How TPE is linked to anti-aging.   You can follow along with Dr. Conboy and her lab's work here. Episode also available on Apple Podcasts: http://apple.co/30PvU9C

On Food Talk with Dani Nierenberg, Dani speaks with Matthew Dillon, Co-CEO of the Organic Trade Association. They discuss why the organic label continues to resonate with eaters, what the budget cuts and staffing reductions at the U.S. Department of Agriculture could mean for food producers, and why support for organic agriculture remains so important for communities today and in the future. Plus hear about the recent decision to approve CRISPR gene-edited pigs for human consumption in the U.S., a new project that will help Libyan producers farm in some of the driest conditions, and the food safety warnings that aren't reaching the public fast enough.   While you're listening, subscribe, rate, and review the show; it would mean the world to us to have your feedback. You can listen to “Food Talk with Dani Nierenberg” wherever you consume your podcasts.

In this thrilling installment of Impact Theory, Tom Bilyeu sits down with Ben Lamm, visionary founder and CEO of Colossal Biosciences, a company on a mission to reverse extinction and rewrite the future of conservation and synthetic biology. Ben and Tom dive deep into the mind-bending world of de-extinction, synthetic gene editing, and how the CRISPR revolution is not only unlocking the secrets of life—but also actively engineering it. In Part 1, get ready for a rollercoaster of concepts as Ben explains the technical magic behind gene editing, DNA synthesis, and multiplex genome editing. From the birth of the woolly mouse to the debated revival of dire wolves, Ben reveals the breakthroughs, challenges, and wild stories behind reviving extinct species. You'll learn how Colossal is using advanced computational biology, AI, and hands-on bioengineering to not only bring animals back but also reshape the future of healthcare, genetics, and ethical decision-making. This is part sci-fi, part practical science, and 100% mind-blowing. SHOWNOTES 00:00 – Kicking Off: The Mysteries of Editing Life 00:14 – Emergence of the CRISPR Revolution 01:31 – What Is DNA Synthesis and Multiplex Editing? 03:47 – The Woolly Mouse: Engineering Traits Across Species 07:54 – Breaking Down the Process: IVF, Screening, and Sequencing 09:24 – Mapping Genotype to Phenotype and Its Challenges 12:10 – Targeting Gene Edits: From Theory to Application in Health and Conservation 17:09 – From Hair Organoids to Building Mammoth Traits in Mice 24:41 – The Quest for a Universal Egg and Overcoming Cellular Barriers 26:17 – Artificial Wombs: The Next Frontier in Conservation and Science 31:12 – Scaling Conservation and Bridging to Human Healthcare FOLLOW BEN LAMM Twitter/X: @federallamm LinkedIn: Ben Lamm CHECK OUT OUR SPONSORS ButcherBox: Ready to level up your meals? Go to ⁠https://ButcherBox.com/impact⁠ to get $20 off your first box and FREE bacon for life with the Bilyeu Box! Vital Proteins: Get 20% off by going to ⁠https://www.vitalproteins.com⁠ and entering promo code IMPACT at check out Shopify: Sign up for your one-dollar-per-month trial period at ⁠https://shopify.com/impact⁠ Netsuite: Download the CFO's Guide to AI and Machine Learning at ⁠https://NetSuite.com/THEORY⁠ iTrust Capital: Use code IMPACTGO when you sign up and fund your account to get a $100 bonus at ⁠https://www.itrustcapital.com/tombilyeu⁠  Mint Mobile: If you like your money, Mint Mobile is for you. Shop plans at ⁠https://mintmobile.com/impact.⁠  DISCLAIMER: Upfront payment of $45 for 3-month 5 gigabyte plan required (equivalent to $15/mo.). New customer offer for first 3 months only, then full-price plan options available. Taxes & fees extra. See MINT MOBILE for details. What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER SCALING a business: see if you qualify here. Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here. ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu's Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ********************************************************************** LISTEN TO IMPACT THEORY AD FREE + BONUS EPISODES on APPLE PODCASTS: apple.co/impacttheory ********************************************************************** FOLLOW TOM: Instagram: https://www.instagram.com/tombilyeu/ Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en Twitter: https://twitter.com/tombilyeu YouTube: https://www.youtube.com/@TomBilyeu Learn more about your ad choices. Visit megaphone.fm/adchoices