Podcasts about SNP

Six party candidates join the Stooshie to go over the priorities for the key by-election, being held on June 18. Join us for a 90-minute special edition with candidates from the Conservatives, SNP, Reform, Labour, Liberal Democrats and Green party.  

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Well, folks, it's been a week of delayed recordings and riveting exchanges. This week, Lesley and Fraser weigh in on a fair old rammy at Holyrood regarding the SNP, plus the deeply troubling scenes playing out on the streets of Belfast and beyond. From a Scottish Parliamentary debate that saw the Green amendment triumph, to the surprising political unity across the water in Northern Ireland, we try to make sense of a highly charged political landscape. In this episode, we discuss:The Peter Murrell Scandal & Holyrood's Response: We unpack the recent debate on whether there should be a Scottish Parliamentary inquiry into the SNP's financial scandal. Fraser argues Holyrood has ducked out of the thornier issues regarding the separation of powers and the Crown Office, leaving the door wide open for Westminster's Scottish Affairs Committee to step in. Lesley, however, reckons an independent inquiry—sparked by the successful Green amendment—is actually the better move, meaning politicians won't just be marking their own homework.A Question of Competence: Does the Scottish Parliament even have the legislative authority to investigate political parties, or is that strictly reserved to Westminster under the Scotland Act? We get into the weeds of who actually holds the power to scrutinise party registration and funding.The Future of Independence Funds: With Peter Murrell reportedly offering to voluntarily repay embezzled funds, we ask what should happen to that money. Fraser suggests a new, democratic independence vehicle should be established to take the ring-fenced crowdfunder cash, rather than simply returning it to the SNP's coffers.Far-Right Riots and The Belfast Response: We turn to the appalling, racist violence in Belfast and across the UK, fueled by outside agitators and Nigel Farage's "pure cold fury" remarks. Yet amidst the nightmare, there is a surprisingly upbeat takeaway: the refreshingly robust, united front from Northern Irish politicians across the divide. From the SDLP to the Democratic Unionists, local leaders have explicitly repudiated the racism and told the armchair warriors exactly where to go. ★ Support this podcast ★

The Scottish Parliament is running, but is it actually getting anything done? In this episode of Holyrood Sources, Calum Macdonald, Geoff Aberdein, and Andy Maciver dive into a massive week for Scottish politics.As Scottish Labour forces a vote on a parliamentary inquiry into Peter Murrell's embezzlement from the SNP, First Minister John Swinney faces intense pressure over his handling of the situation. Should he have brought in a KC to clean house, or is he right to treat it as "case closed"? We break down the constitutional battle brewing as Westminster's Scottish Affairs Committee threatens to step in.Plus, we expose a glaring economic contradiction at the heart of the Scottish Government: debating wealth taxes one week and demanding economic growth the next. We also react to a brilliant, straight-talking 6-point listener manifesto for the SNP, debate the failure of elected committee conveners, and unpack the transport chaos plaguing Scotland. Hosted on Acast. See acast.com/privacy for more information.

The conviction of former SNP Chief Executive Peter Murrell has sent shockwaves through Scottish politics and raised serious questions about financial oversight, leadership responsibility and public trust.In this episode of Crime Time Inc., former detectives Tom Wood and Simon McLean examine the embezzlement case that dominated headlines across Scotland. Drawing on decades of investigative experience, they explore how breaches of trust develop, why embezzlement often goes undetected for years, and what warning signs organisations frequently miss.Tom and Simon compare the SNP case with real investigations from their policing careers, including thefts involving trusted employees, family-run businesses and compulsive offenders whose behaviour defied logic. They discuss the difference between crimes driven by need, greed and psychological compulsion, and analyse the extraordinary purchasing patterns revealed during the investigation.The conversation also turns to leadership accountability, internal financial controls, governance failures and the responsibilities of those entrusted with managing large organisations and public donations.In the second half of the episode, the hosts address the tragic rise in child and teenage drowning deaths across the UK. They discuss water safety, cold water shock, risk-taking behaviour among young people, and whether schools and parents are doing enough to prepare children for everyday dangers.A thought-provoking discussion on crime, trust, responsibility and the lessons that organisations and families ignore at their peril.The discussion also examines the wider implications of Operation Branchform, the investigation into Scottish National Party finances, and the questions raised about oversight during the leadership of Nicola Sturgeon. Drawing on their experience as former detectives, Tom Wood and Simon McLean provide insight into how fraud investigations develop, why financial controls fail, and what lessons organisations can learn from high-profile cases. The episode concludes with an important discussion on water safety, drowning prevention and the risks of cold water immersion.Chapters00:00 Introduction to the SNP Embezzlement Case01:20 How Embezzlement Typically Begins05:44 A Detective's Real-Life £74,000 Theft Investigation09:40 Need, Greed and Compulsive Theft16:37 The Strange Psychology of Criminal Behaviour18:45 Comparing Major Financial Crime Cases21:14 Leadership Accountability and Governance Failures23:58 Water Safety and Preventable Tragedies25:46 Why Young People Are Most at Risk28:13 The Green Cross Code and Safety LessonsAbout Crime Time Inc.Season 5 of Crime Time Inc. broadens its reach across two sides of the Atlantic.This season features cases from Scotland and across the wider UK — rooted in real investigative experience — alongside deep dives into some of the most infamous murder cases in American history.Hosted by former detectives Simon and Tom, with experience in both the UK and the United States, including time working alongside the FBI, the show strips away sensationalism to explain how crime and justice really work.Two crime worlds. One podcast.New episodes released regularly throughout the season.Our Website: https://crimetimeinc.com/If you like this show please leave a review. It really helps us.Please help us improve our Podcast by completing this survey.http://bit.ly/crimetimeinc-survey Hosted on Acast. See acast.com/privacy for more information.

Welcome to a revamped Everything Compliance Shout Outs and Rants. We have a new host, Adam Turteltaub, and a new panelist, Rebecca Walker, who joins returning regulars Matt Kelly, Jonathan Armstrong, and Karen Moore for the next iteration of Everything Compliance Shout Outs and Rants. Adam thanks Tom Fox, critiques his own timing, and notes Pope Leo XIV's AI encyclical urging attention to human factors. Rebecca praises Georgetown University's Jesuit values—“men and women for others” and cura personalis—as a reminder that compliance is about values and culture, not just enforcement. Matt echoes interest in the Pope's encyclical, criticizes President Trump's comments about the Pope, and cites Amazon's warning against gaming internal AI leaderboards, arguing companies should prioritize productive outcomes over measuring AI usage. Karen describes her gym's behavior memo and criticizes the shift toward enforcing it on members. Jonathan discusses the SNP embezzlement case involving Peter Murrell and related allegations around Nicola Sturgeon, highlighting compliance lessons: segregation of duties, conflicts of interest, whistleblowers, and culture. Everything Compliance Shout-Outs and Rants is a production of the Compliance Podcast Network.

If you are worried about China taking over due to having better robots than the yanks, I got mixed messages for ya here. This was created using DeepSeek v4 Pro. Remember when DeepSeek could do the same thing as chatGPT but on shitty processors and not much RAM? All those stocks shit themselves? Oh what memories. Would have been a great time to buy NVIDIA stocks. I didn't, if you're asking....It's pretty good but it really didn't follow the instruction in the prompt that Joel Hill is Jack the Insider on the transcript. So that's a minus point. But also, this took fucking ages to generate. It's better than lots of the yankee slop but damn son this took MINUTES. So they might take over if we are patient or whatever. Enjoy the episode. ----------------------------------------------Joel Hill (Jack the Insider) and Hong Kong Jack return for a sprawling episode that tackles two of the biggest stories shaping politics in 2026. The pair open with the jaw-dropping Redbridge poll putting One Nation at 31% of the primary vote — a number that would all but wipe the National Party off the federal map and potentially deliver Anthony Albanese a strengthened majority government by splintering the right. Joel and Jack clash over whether culture-war grievances or material concerns are driving the surge, while drawing historical parallels to Joh for Canberra and the DLP split of the 1950s.The conversation then crosses hemispheres for a tour through UK chaos: Peter Mandelson's leaked dossier exposing a rudderless No. 10 under Keir Starmer, Nicola Sturgeon's estranged husband pleading guilty to embezzling SNP donations on a surreal shopping spree of Lalique salt shakers, seven Dysons, and a motorhome with four miles on the clock, and a deeply troubling police body-cam incident that has reignited the two-tier policing debate ahead of three critical by-elections.The centrepiece of the episode is a sober, hour-long deep dive into the COVID-19 pandemic and what Australia has refused to learn. The Two Jacks lay out the true death toll (perhaps 22 to 69 million globally), the devastating scale of long COVID, the vaccine rollout failures, the absurdities of hotel quarantine with rubbish bags over heads, and why governments and public health officials are desperate to avoid a Royal Commission. They close by asking whether the next pandemic will meet a population that has permanently lost trust in its leaders — and whether we'll simply repeat the mistakes of both COVID and the Spanish flu.Sport provides a lighter coda: the Carlton revival under an interim coach, James Hird's awkward candidacy at Essendon, the expanded 48-team World Cup that nobody seems excited about, and a formidable New Zealand Test side taking on England at Lord's.00:00:25 — Introduction Joel welcomes listeners to Episode 159, recorded 4 June. Today: Australian political news, a check-in on the UK, and a deep dive into the COVID-19 pandemic.00:01:21 — The Redbridge Poll: One Nation at 31% The AFR's Redbridge poll: One Nation 31%, Labor 28%, LNP 20%, Greens 12%. The two-party preferred is now being calculated as One Nation versus Labor — a seismic shift in how Australian politics is measured.00:03:12 — Not Just a Protest Vote Jack argues this is real, not a re-run of Hanson's 1990s flash-in-the-pan. The South Australian state election and the Farrah by-election suggest One Nation support is durable. Joel counters that protest votes can be expressed at the ballot box and that Australians are tiring of pluralism.00:04:09 — If One Nation Succeeds, Labor Wins The cruel irony: One Nation's rise probably delivers Labor government. The National Party could simply disappear. The DLP kept the Coalition in power for decades as an anti-Labor party; One Nation may do the reverse.00:05:46 — Scrutiny and Splintering Joel notes One Nation's policies are "two-sentence fragments" and motherhood statements. When proper scrutiny arrives, the contradictions will surface. Hanson's parliamentary attendance is as poor as imaginable.00:08:22 — The Third Rail Jack argues populists succeed because they discuss what polite society won't: immigration, culture wars, welcome to country rituals. The major parties must engage these topics or cede the ground entirely.00:11:34 — Feeling Unheard The core driver, Jack contends: voters feel sneered at and silenced by mainstream politics. It's not about flag counts, it's about being listened to.00:13:50 — What Actually Drives Votes Joel pushes back: voting determinants are the household economy, migration, climate change — not culture war trivia. Culture wars "don't amount to a hill of beans" at the ballot box.00:14:51 — The DLP Parallel Both agree the One Nation phenomenon most closely resembles the DLP split of the 1950s and 60s — a right-wing fracture that delivered Labor government after Labor government.00:17:18 — The Republic Referendum Lesson Jack recalls the 1999 republic referendum: pro-republicans split between models rather than uniting, scuppering the whole project. Voters will vote their preference even knowing it helps their enemy.00:19:32 — UK Parallels: Accommodate or Fight? Significant figures in the UK Tory party are debating whether to fight Reform or reach an accommodation. Tony Abbott recently said the Liberal Party won't criticise Pauline Hanson.00:21:48 — Joh for Canberra Redux Imre Salusinszky's comparison: this is "Joh for Canberra" all over again. But Joel notes Joh's moment lasted months; One Nation's has already lasted years.00:24:08 — State Election Previews Joel predicts the Victorian state election will be chaotic and peculiar — a government that's been in power too long, an opposition that may not be up to the task, and One Nation peeling votes from safe Labor seats. NSW will give a clearer reading.00:25:44 — Hanson "Ready to Govern" — from the Senate? Pauline Hanson announced she's ready to govern. Joel asks: shouldn't she contest a lower-house seat first? Jack recalls the only precedent: John Gorton became PM while still a senator, but had to be eased into Kooyong.00:28:20 — The Mandelson Dossier: Starmer's Empty Suit Jack's read of the leaked Mandelson documents: ministers don't know what the PM wants, there's zero respect or fear of his authority. Starmer comes across as an empty chair. One minister's text: "Every meeting with Labour MPs — it's all about who can we tax to pay benefits to other people."00:30:50 — Mandelson's Legal Peril Mandelson is under police investigation for misconduct in public office. Could face charges — the seriousness depends on whether it's mere misconduct or genuine bribery for foreign interests.00:31:49 — The Nicola Sturgeon Saga Her estranged husband has pleaded guilty to embezzling roughly £400,000 in SNP donations. The shopping list: six high-end coffee machines, seven Dyson vacuums, Lalique salt and pepper shakers, Montblanc pens, Swiss watches, an iJag, part of a Volkswagen, and a motorhome with four miles on the clock parked at his 92-year-old mother's house. Nicola claims she "didn't go in the kitchen much."00:34:20 — The BBC Interview Laura Kuenssberg's forensic interview with Sturgeon — "not quite Prince Andrew, but not much better." Sturgeon has been cleared by Police Scotland, but her reputation, already damaged by the Alex Salmond trial, is now in tatters.00:35:05 — Will He Go to Prison? £400,000 is a substantial sum. With another £600,000 unaccounted for, a custodial sentence seems likely. The money was ring-fenced for a second independence referendum push.00:36:50 — Money Laundering or Conspicuous Consumption? Joel wonders if the bizarre purchases — multiple watches on the same day — were an amateur money-laundering attempt: buy goods with SNP funds, sell them quietly for cash.00:38:23 — UK By-elections: Makerfield Looms Three by-elections on 18 June, including the critical Makerfield contest. Andy Burnham, Greater Manchester's high-profile mayor, is the tepid favourite. Low turnout could help him return to Westminster.00:39:30 — The Body-Cam Incident A white teenager accused of racially vilifying a Sikh man was stabbed — and police arrested the bleeding victim, not the attacker. Body-cam footage shows the victim saying "I can't breathe, I've been stabbed" while officers dismiss him. Joel calls the footage "just awful."00:41:22 — Two-Tier Policing Jack traces UK policing's overcorrection: after the Macpherson/Lawrence report, guidelines were rewritten so aggressively that they've produced a pattern of questionable enforcement that devastates community trust — and plays directly into Tommy Robinson's hands.00:42:08 — NSW Police on Four Corners Joel recommends the harrowing Four Corners investigation: bashings in custody, false arrests, an officer who threw body-cam footage into Sydney Harbour, and two undercover officers jailed for a savage assault. The problem today is general duties policing, not the specialist squads of the 1980s. Some command areas are far worse than others — a leadership failure.00:44:55 — Victoria Police: Under-Resourced, Not Corrupt Joel shares an anecdote: two divisional vans for 80,000 people in outer-east Melbourne. Tough work being a police officer; even tougher being a good one.The COVID-19 Reckoning00:45:09 — Why This Matters Joel sets the frame: we parked COVID in 2023 with a hangover but never understood what we'd been through. Today's episode aims to crack that problem.00:45:51 — The True Death Toll Officially: 7 million dead. But most countries stopped testing and stopped reporting cause-of-death data to the WHO. Using excess mortality, the real toll is between 22 and 69 million — at the high end, exceeding the Spanish flu.00:47:02 — Long COVID's Shadow Roughly 400 million people globally (6% of the population) have experienced long COVID. In Australia alone, between 200,000 and 500,000 people are living with or have lived with the condition. Second infections can be worse. Emerging links to cardiovascular disease, type 2 diabetes, and accelerated dementia.00:49:43 — The Collective Amnesia Governments worldwide have "a collective embarrassment" about how they handled the pandemic, Jack says. They want it in the history books and forgotten. Joel says this is a grave mistake for public trust — and for public health, given COVID is now a permanent fixture alongside flu season.00:50:50 — Why Excess Deaths Are the Only Honest Metric All other figures are "kind of made up" because attribution methods vary wildly between countries. Excess deaths remain elevated in Australia and most nations.00:51:25 — Children and COVID Bobby Kennedy Jr. removed under-18s from government-supported vaccines in the US. Joel argues this is a disastrous move given mounting evidence that childhood COVID infection leads to higher rates of long-term chronic illness.00:52:47 — Why No Royal Commission? Not just politicians protecting themselves — public health officials and much of the media wanted to avoid scrutiny of their judgments and actions during the pandemic.00:53:32 — The Media's Abdication Jack watched "a lot" of Daniel Andrews's daily press conferences. Only two journalists ever asked pertinent questions: Rachel Baxendale and Leigh Sales. Nobody asked why curfews, why beach arrests, why the disparate impact on tradies and cafe owners while the "laptop class" actually made money working from home.00:56:14 — Andrews's Immense Popularity Joel adds context: Andrews was wildly popular at the time, which partly explains the media's deference — though Jack insists that shouldn't have mattered.00:57:34 — The Curfew Nonsense Curfews were about giving law enforcement the easiest possible environment, Joel says — and should have been acknowledged as such and wound back sooner. Meanwhile, Bondi's wealthy swam en masse while Western Sydney's working-class communities were treated harshly.00:57:59 — The Vaccine Rollout Failure The Morrison government bet everything on AstraZeneca — the non-mRNA, first-available vaccine. Then rare blood-clotting issues emerged (seven deaths, mainly men aged 40–49). Meanwhile, Australia was left waiting for Pfizer and other mRNA vaccines because no other supply deals had been secured.00:59:37 — Omicron Breaks the Pandemic's Back The Omicron variant emerged from South Africa: more infectious but far less lethal. Combined with 95%+ vaccination rates among Australians over 18, it effectively ended the acute phase — though at the cost of entrenched mistrust.01:00:38 — Government Overreach and Broken Trust Jack's core criticism: governments outsourced decision-making to public health officials rather than making political judgments that balanced competing interests. Joel counters that it would have been a "bold move" for politicians with no scientific background to contradict public health advice.01:02:19 — "Just Let It Rip" Was Never an Option The three countries with the highest COVID mortality — Brazil (highest), United States (second), India (third) — were all led by populist governments that largely refused mandates. Letting it rip was devastating.01:03:27 — The ADF Quarantine Scandal Scott Morrison refused to allow ADF quarantine facilities to be used for returning travellers. Instead, people were crammed into hotels with gaps under the doors. Joel recalls the "rubbish bags over heads" episode in Victoria — dark green plastic bags as infection control.01:05:00 — The Inquiry's Recommendations Create a proper Australian CDC. Release expert advice publicly. Better national planning with clear political accountability. And critically: politicians must own the big decisions on freedoms and spending instead of hiding behind experts.01:06:01 — The Next Pandemic There will be another one. If it's a respiratory, airborne pathogen like COVID, similar circumstances will return. Are we ready? Probably not. Will we close the country again? The economic damage — unemployment hitting 7.5% in 2020 — was enormous, even if it recovered to 3.5% by pandemic's end.01:08:06 — Who Was Left Behind? The arts community was inexplicably excluded from JobSeeker and JobKeeper. Meanwhile, the "laptop class" working from home effectively got a 15% pay rise by eliminating commuting costs. Bunnings did very well; so did companies that kept JobKeeper without passing it to employees.01:11:14 — The Human Cost of Lockdowns Public housing towers in Flemington were locked down. Joel recalls one family: an African-Australian single mother with nine children in a two-bedroom commission flat, trapped. Jack calls what happened with schools "disgraceful." But Joel notes the evidence now shows childhood COVID infection has serious long-term health consequences, complicating the retrospective judgment.01:13:59 — Will We Learn Anything? Jack's bleak prediction: the next pandemic is probably far enough away that we'll take no notice of COVID's lessons and make the same mistakes. Joel agrees — we didn't learn from the Spanish flu a century ago either.01:15:51 — Malcolm Roberts and Vaccine Misinformation The One Nation senator claims 70,000 Australians died from COVID vaccines — a figure with no evidentiary support, built by misattributing excess deaths. In reality, mRNA technology is now being deployed as a cancer treatment, showing promise against bowel and pancreatic cancers.01:17:36 — Trust Destroyed If the next pandemic arrives within this generation, governments will face a population that has lost faith. If it takes 50 years, the damage may have faded. Western Australia, meanwhile, locked itself down with negligible deaths and actually loved the isolation — provided the iron ore and LNG ships kept moving.01:20:37 — The Spanish Flu Echo Joel's closing historical note: Australia's response to the Spanish flu in 1919–1921 was nearly identical to COVID — lockdown disputes, police arresting people for not wearing masks, states fighting the newly created federal Department of Health. The whole thing collapsed into acrimony the moment state rivalries flared. A century later, nothing had changed.01:21:48 — Federation as Fatal Flaw Jack adds: the three high-mortality COVID countries (US, Brazil, India) share a feature beyond populist leaders — they're all federations where central government power is limited. When "the emperor is far away and the mountains are high," coordinated pandemic response is nearly impossible.01:23:40 — No Appetite for Truth Jack's final word: nobody wants a proper inquiry. Not politicians, not public health officials, not much of the media. Joel disagrees on the importance — the pandemic's legacy still shapes how Australians think, vote, and trust.Sport01:27:40 — AFL Coaching Carousel Essendon and Carlton both need permanent coaches. Joel asks: is James Hird the right man for Essendon? Jack: 17 other clubs wouldn't give him an interview, but the Bombers may have backed themselves into a corner where appointing him is the only way out.01:28:53 — Merit vs Member Sentiment Rowan Connolly's question: would you take James Hird or John Longmire (five grand finals, one premiership, 60%+ win rate)? The answer is obvious on merit — but members and fans want the fairy tale.01:29:47 — Carlton's Astonishing Revival Three straight wins. Ranked 16th in forward-50 entries a month ago; now second. The game style is unrecognisable — no more bombing the ball to non-existent power forwards. Mitch McGovern's low, flat kick to Patrick Cripps for the match-winner against Geelong was emblematic of the transformation. Seven players aged 21 or younger are now getting games and bringing energy.01:33:18 — FIFA World Cup 2026: Nobody's Excited Expanded to 48 teams, Scotland are going — and a Scot in his 30s told Jack that neither he nor any of his mates (all doing well financially, normally first on the plane) have any interest. Ticket prices are "extraordinary." The final is at MetLife Stadium in New Jersey — which Jack describes as "Waverley on steroids, but even more bleak."01:36:08 — Australia's Draw Socceroos face Turkey first up, then the United States. Jack suggests marketing it as "Gallipoli Round Two." Spain are favourites; England, Brazil, and Germany are in the chasing pack.01:37:06 — Cricket: England v New Zealand, First Test at Lord's Joel runs through New Zealand's likely top seven — Latham, Conway, Williamson, Ravindra, Mitchell, Blundell — noting the first four have all made Test double-centuries. "Just about the best first six in Test cricket." With O'Rourke's express pace and Henry's quality, this is a formidable Black Caps side.01:38:40 — Stump Speech & Next Week Listener mail (including an "exposé of who Jack is") held over for next episode. For the record: Hong Kong Jack's CV includes HSC at Assumption College Kilmore, a stint as a carpenter, a law degree from Melbourne University, stints at Holding Redlich and Slater & Gordon, work as a litigation and immigration lawyer, and an appointment to the Refugee Review Tribunal as a federal cabinet appointee.01:40:39 — Outro Joel thanks listeners for hanging in for an extra ten minutes. Back next week.The Two Jacks is recorded weekly. Send your questions and feedback to the show.

Ce lundi 8 juin, Antoine Larigaudrie a reçu Gustav Sonden, cofondateur de Colbr, et Vincent Grard, directeur France Trade Republic, dans l'émission Tout pour investir sur BFM Business. Retrouvez l'émission du lundi au vendredi et réécoutez la en podcast.

Nicola Sturgeon has claimed she was deceived by her ex-husband Peter Murrell who pled guilty having embezzled tens of thousands of pounds of SNP money. Financial infidelity has become a top reason behind couples divorces. Alice Wright from The Times joins Michael Simmons to discuss. Hosted on Acast. See acast.com/privacy for more information.

Eva je doslova dieťa holokaustu: narodila sa v pracovnom tábore pre Židov v Novákoch. Po vypuknutí SNP odišli do Piešťan, žili s falšovanými dokladmi. Po prezradení boli odvlečení do tábora v Žiline, neskôr do Serede v novembri 1944 ich deportovali do Auschwitzu, kde videli otca naposledy. Odišla do Západného Nemecka, kde žil jej manžel, rodičia prišli za ňou. V roku 1971 nečakane ovdovela, neskôr sa zamestnala a opäť sa vydala, porodila ďalších dvoch synov, po pôrode tretieho sa jej obnovila trauma z prežitého holokaustu. Vyštudovala psychoterapiu, venuje sa osvetovej činnosti a vzdelávaniu. Napísala životopisnú knihu „Číslo na tvojom predlaktí je modré ako tvoje oči“.

Andy Zaltzman is joined by his panel of political satirists to unpack the critical essays of Tony Blair, the spending habits of Peter Murrell and the SNP, the sweltering heat, social media ban proposals for under 16's and young people in record levels of unemployment.This week's panellists are Scott Bennett, Cody Dahler, Ayesha Hazarika and Bella Hull.Written by Andy Zaltzman.With additional material by: Angela Channel, Sam Nicoresti, Pravanya Pillay and Peter Tellouche. Producer: Rajiv Karia Executive Producer: Pete Strauss Production Coordinator: Asha Osborne-Grinter Sound Editor: Marc WillcoxA BBC Studios Production for Radio 4.

In this week's edition of the News Review on the PRmoment podcast, host Ben Smith, is joined by industry heavyweights Mark Borkowski and Angie Moxham to dissect one of the most significant political crisis management events of the year: Nicola Sturgeon's high-stakes sit-down interview with Laura Kuenssberg on the BBC. Following her estranged husband Peter Murrell's recent guilty plea to embezzling over £400,000 from the SNP, the former First Minister faced an intense 55-minute interrogation aimed at shifting the narrative from political complicity to personal betrayal.Ben kicks off the discussion by questioning whether the interview succeeded in separating Sturgeon's personal reputation from the unfolding financial scandal of the party she led for nearly a decade. Mark Borkowski offers a sharp critique of the crisis communications strategy, noting that while Sturgeon's performance was emotionally raw—particularly when discussing a £425 necklace bought with stolen funds—it ultimately struggled under the weight of incredulity. He argues that her core defense—claiming she had no "conscious memory" of a massive motorhome parked outside her mother-in-law's house—strained public belief, leaving the "brand" of Sturgeon severely damaged despite her formidable media skills.Angie Moxham shifts the lens toward the gender dynamics and long-term reputational impact. Moxham observes that Sturgeon deliberately weaponized a highly relatable narrative: the trope of a successful woman being unfairly blamed for the hidden, fraudulent actions of the man in her life. While Angie acknowledges that this framing could resonate strongly with a core segment of the public and female voters, she questions whether it can truly repair the massive trust deficit currently facing the SNP. Moxham analyzes how the "personal vs. political" mashup plays out for independent brand survival, noting that Sturgeon's insistence that she is “serving a sentence for a crime I did not commit” effectively positions her as the primary victim, eclipsing the independence donors whose money was actually taken.The panel agrees that while the BBC gave Sturgeon the necessary space to outline her trauma and bewilderment, the interview highlights the near-impossible task of separating a leader's legacy from systemic organizational failure. Ultimately, the review concludes that while Sturgeon successfully reminded the public of her formidable communication prowess, the sheer volume of high-value goods involved makes an absolute reputational recovery unlikely.Finally, Ben closes the segment with an important industry notice, urging listeners to submit their entries for the upcoming Creative Moment Awards before the final entry deadline on June 19th.You can watch the Sunday with Laura Kuenssberg Interview to see the exact moment Nicola Sturgeon addresses the embezzlement scandal and discusses the personal toll it has taken on her life.

Alistair Grant, Catriona Stewart and Andrew Quinn discuss the latest on Peter Murrell - as well as the questions surrounding the SNP's 'ring-fenced' indyref fund. Learn more about your ad choices. Visit podcastchoices.com/adchoices

The prime minister has accused Elon Musk of 'interfering' in UK politics, after he posted repeatedly on X about the police's treatment of Henry Nowak.NHS England says it will ban staff from wearing political badges as part of measures aimed at tacking antisemitism and other forms of racism. Britain's only serving female commando Lieutenant Lily-Mae Fisher has been named as one of the three members of the Royal Navy who died in a helicopter crash yesterday. She was on board the Merlin 4 aircraft alongside 42-year-old Lieutenant Commander Chris Gayson and 24-year-old Petty Officer Owen Green.Scotland's First Minister John Swinney has said his party may have claimed back tax on items purchased by its former chief executive Peter Murrell, who last week admitted embezzling more than 400 thousand pounds from the SNP.01:56 Henry Nowak treatment 06:50 NHS antisemitism measures 10:06 Helicopter pilots named 12:05 Lebanon ceasefire 15:04 SNP on Murrell's tax 17:46 World Cup water bottles 20:02 Teacher shortages 21:54 Hampshire rape sentencing 24:30 Strikes in Crimea 27:59 Bob Harris tribute(Image: Reuters)

Morse code transcription: vvv vvv Cara Delevingne on sobriety and mental health inspiring her music Maga influencer Melissa Rein Lively admits Bond Street assault Henry Nowak arrest footage raises serious questions for police, PM says Three quarters of workers not on track for moderate pension income, report suggests Police pelted with missiles at Henry Nowak protest Peter Murrell used SNP cards for 400,000 spending spree Murdered student Henry Nowak told police I cant breathe while handcuffed Llanelli Tata staff steal 1.2m of tin and sell for scrap British couple Lindsay and Craig Foreman lose Iran jail sentence appeal, family says US says it fired missile at Iran bound oil tanker

A new Netflix documentary follows the final stage of Rafael Nadal's tennis career. The series is the latest high-profile sports documentary made for a streaming platform. Zachary Heinzerling, director of Rafa, outlines how the film was made and the level of access his team received. Minal Modha, senior research director at Ampere Analysis, provides context on the growing business of sports documentaries.In Scotland, Peter Murrell's guilty plea to embezzling funds from the SNP has renewed attention on the reporting that first raised questions about the affair. John Ferguson, political editor at the Sunday Mail, reflects on his own journalism. Laura Kuenssberg explains how she secured the first broadcast interview with Nicola Sturgeon since her estranged husband's conviction.CBS News is facing upheaval following changes in leadership and the departure of several senior figures. The latest developments centre on the dismissal of veteran correspondent Scott Pelley after public criticism of the network's direction. Michael Grynbaum, media correspondent at The New York Times, outlines the story.Presenter: Katie Razzall and Ros Atkins Producer: Lisa Jenkinson and Lucy Wai Researcher: Ruth Waites Sound engineer: Volodymyr Muzyczka

Morse code transcription: vvv vvv Murdered student Henry Nowak told police I cant breathe while handcuffed Three quarters of workers not on track for moderate pension income, report suggests US says it fired missile at Iran bound oil tanker Police pelted with missiles at Henry Nowak protest Maga influencer Melissa Rein Lively admits Bond Street assault Cara Delevingne on sobriety and mental health inspiring her music Peter Murrell used SNP cards for 400,000 spending spree British couple Lindsay and Craig Foreman lose Iran jail sentence appeal, family says Llanelli Tata staff steal 1.2m of tin and sell for scrap Henry Nowak arrest footage raises serious questions for police, PM says

Morse code transcription: vvv vvv Cara Delevingne on sobriety and mental health inspiring her music US says it fired missile at Iran bound oil tanker Murdered student Henry Nowak told police I cant breathe while handcuffed British couple Lindsay and Craig Foreman lose Iran jail sentence appeal, family says Police pelted with missiles at Henry Nowak protest Maga influencer Melissa Rein Lively admits Bond Street assault Henry Nowak arrest footage raises serious questions for police, PM says Llanelli Tata staff steal 1.2m of tin and sell for scrap Peter Murrell used SNP cards for 400,000 spending spree Three quarters of workers not on track for moderate pension income, report suggests

Morse code transcription: vvv vvv Henry Nowak arrest footage raises serious questions for police, PM says Llanelli Tata staff steal 1.2m of tin and sell for scrap US says it fired missile at Iran bound oil tanker Murdered student Henry Nowak told police I cant breathe while handcuffed Maga influencer Melissa Rein Lively admits Bond Street assault Police pelted with missiles at Henry Nowak protest Peter Murrell used SNP cards for 400,000 spending spree Cara Delevingne on sobriety and mental health inspiring her music British couple Lindsay and Craig Foreman lose Iran jail sentence appeal, family says Three quarters of workers not on track for moderate pension income, report suggests

Fast cars, luxury watches – and, of course, that motorhome: the list of what former SNP chief executive Peter Murrell bought with embezzled funds is dizzying. Severin Carrell reports.. Help support our independent journalism at theguardian.com/infocus

What does the SNP embezzlement case reveal about how scandal-ridden British politics is? Is the banning of prominent left-wing American commentators Hasan Piker and Cenk Uygur a sensible decision or a serious threat to free speech? After Rory and Alastair discussed their most “evil” handshakes last week, who is the most “angelic” person they have each shaken hands with? Join Rory and Alastair as they answer all these questions and more in this week's edition of Question Time. __________ Go deeper into the world of The Rest Is Politics by signing up for our free newsletter HERE, featuring exclusive interviews, analysis and weekend reads from Alastair and Rory. Join The Rest Is Politics Plus. Start your free trial at therestispolitics.com to unlock exclusive bonus content – including Rory and Alastair's miniseries – plus ad-free listening, early access to episodes and live show tickets, exclusive newsletters, discounted book prices, and a private chatroom on Discord. The Rest Is Politics is powered by Fuse Energy. Stop overpaying for energy. Switch at fuseenergy.com/politics and get a free TRIP+ subscription. Get our exclusive NordVPN deal here ➼ nordvpn.com/restispolitics It's risk-free with Nord's 30 day money back guarantee ✅ __________ Instagram: @restispolitics Twitter: @restispolitics Email: therestispolitics@goalhanger.com __________ Social Producer: Celine Charles Video Editor: Adam Thornton, Vasco Andrade Assistant Producer: Daisy Alston-Horne Producer: Evan Green Exec Producer: Chris Sawyer General Manager: Tom Whiter Learn more about your ad choices. Visit podcastchoices.com/adchoices

Peter Murrell, the former chief executive of the SNP and estranged husband of Nicola Sturgeon, has admitted embezzling more than £400,000 from the Scottish National Party. Which is quite a sentence, even by the standards of modern politics, where the bar is now lying somewhere in a ditch wearing a hi-vis jacket.In this episode of Mark and Pete, we look at the Peter Murrell SNP scandal, the political fallout for Nicola Sturgeon, and the bigger question facing Scottish nationalism: how did a party that wanted to govern an independent Scotland fail to notice what was happening inside its own finances?This is not an episode claiming Nicola Sturgeon committed a crime. She denies knowledge of Murrell's actions and has been cleared by police. But politics is not only about criminal guilt. It is also about responsibility, judgement, leadership, culture, and whether the people at the top were really as in control as they claimed to be. And that, frankly, is where the story becomes more interesting, and rather less comfortable.We discuss the SNP's long-standing image as the clean, competent alternative to Westminster, the collapse of that moral authority, Operation Branchform, the infamous motorhome, party trust, Scottish independence, political accountability, and the strange spectacle of a nationalist movement damaged not by Westminster oppression, but by its own internal chaos.There is also a Bible verse, naturally, because Mark and Pete are not here merely to gawp at the wreckage like political pigeons. Proverbs says, “He that walketh uprightly walketh surely: but he that perverteth his ways shall be known.” That seems uncomfortably apt.So what did Nicola Sturgeon know? What should she have known? And what does the Peter Murrell embezzlement case tell us about the SNP, Scottish politics, and the danger of confusing political confidence with actual competence?A sharp, Christian, sardonic look at one of the biggest political scandals in recent Scottish history.

The BBC's Laura Kuenssberg joins Ros and Katie to discuss her exclusive interview with Nicola Sturgeon, the first since her estranged husband pleaded guilty to embezzling £400,000 from the SNP. John Ferguson, Political Editor at the Sunday Mail in Scotland, also shares his experience of reporting on the story from the very beginning. Also on the programme, director Zach Heinzerling discusses how he secured unprecedented access to tennis player Rafael Nadal for his Netflix documentary Rafa. Minal Modha from Ampere Analysis assesses whether we are in the middle of a sports documentary boom. Plus, analysis of the ruptures in CBS' 60 Minutes newsroom by Michael Grynbaum from The New York Times.

Morse code transcription: vvv vvv How former SNP chief executive Peter Murrell spent the 400,000 he embezzled OpenAI let ChatGPT aid and abet mass shooters, Florida suit says British woman dies after Pyrenees peak fall Britains earliest prehistoric art found in Gowers Bacon Hole cave Rosamund Pike calls out audience member for texting during show River Don searches continue for 11 year old Mackenzie Swift Weapons obsessed killer Vickrum Digwa jailed for Henry Nowaks murder Bowen Trump needs this war to end but Iran is not backing down Bereft and beleaguered stark criticism revealed in Mandelson messages London Tube strikes to go ahead as negotiations break down

Morse code transcription: vvv vvv Meta AI chatbot enabled hackers to access others Instagram accounts UK Athletics fined 350,000 over death of Paralympic shot putter at training facility Peter Murrell used SNP cards for 400,000 spending spree Heatwave in Banda A day in the hottest place in India Maga influencer Melissa Rein Lively admits Bond Street assault Cara Delevingne on sobriety and mental health inspiring her music Sabrina Carpenter gets restraining order against man who showed up at her home Murdered student Henry Nowak told police I cant breathe while handcuffed Toy Story 5 Tom Hanks says film tackles terror of technology The questions left unanswered by the Mandelson files

Een Jaguar I-Pace van ruim 80.000 pond, een superdeluxe camper, een peper en zout stel van Lalique, maar liefst zes Nintendo consoles, een elektronische grasmaaier, Le Creuset pannen, meerdere vulpennen van Montblanc, dure horloges en een puntenslijper van 110 pond: dit is een kleine grepen uit de aankopen van Peter Murrel, voormalig partijdirecteur van de SNP en tevens de ex-man van oud-premier van Schotland Nicola Sturgeon. Al dit moois werd betaald van de 400.000 pond die hij uit de partijpot had gestolen. Dan een vrij confronterende uitkomst van het langverwachte Milburn rapport, de conclusie van onderzoeker en voormalig minister van gezondheidszorg Alan Milburn is vernietigend en pijnlijk confronterend: Met meer dan een miljoen jongeren zonder werk dreigt het Verenigd Koninkrijk te maken te krijgen met een verloren generatie. Met de toename van het aantal e-bikes, het roekeloze rijgedrag en daarmee ook de toename van het aantal ongelukken wil het Verenigd Koninkrijk een snelheidslimiet invoeren. Dit idee hebben ze niet zelf bedacht maar afgekeken van Nederland fietsland. Over Van Bekhovens Britten In van Bekhovens Britten praten Lia van Bekhoven en Connor Clerx elke week over de grootste nieuwsonderwerpen en de belangrijkste ontwikkelingen in het Verenigd Koninkrijk. Van Brexit naar binnenlandse politiek, van de Royals tot de tabloids. Waarom fascineert het VK Nederlanders meer dan zo veel andere Europese landen? Welke rol speelt het vooralsnog Verenigd Koninkrijk in Europa, nu het woord Brexit uit het Britse leven lijkt verbannen, maar de gevolgen van de beslissing om uit de EU te stappen iedere dag duidelijker worden? Na ruim 45 jaar onder de Britten heeft Lia van Bekhoven een unieke kijk op het Verenigd Koninkrijk. Als inwoner, maar zeker geen anglofiel, heeft ze een scherpe blik op het nieuws, de politiek, de monarchie en het dagelijkse leven aan de overkant van de Noordzee. Elke woensdag krijg je een nieuwe podcast over het leven van Van Bekhovens Britten in je podcastapp. Scherpe analyses, diepgang waar op de radio geen tijd voor is en een flinke portie humor. Abonneer en mis geen aflevering. Over Lia Lia van Bekhoven is correspondent Verenigd Koninkrijk voor onder andere BNR Nieuwsradio, VRT, Knack en Elsevier en is regelmatig in talkshows te zien als duider van het nieuws uit het VK. Ze woont sinds 1976 in Londen, en is naast correspondent voor radio, televisie en geschreven media ook auteur van de boeken Mama gaat uit dansen, het erfgoed van Diana, prinses van Wales (1997), Land van de gespleten God, Noord-Ierland en de troubles (2000), In Londen, 9 wandelingen door de Britse hoofdstad (2009) en Klein-Brittannië (2022).See omnystudio.com/listener for privacy information.

Morse code transcription: vvv vvv Meta AI chatbot enabled hackers to access others Instagram accounts Heatwave in Banda A day in the hottest place in India Murdered student Henry Nowak told police I cant breathe while handcuffed UK Athletics fined 350,000 over death of Paralympic shot putter at training facility Peter Murrell used SNP cards for 400,000 spending spree Sabrina Carpenter gets restraining order against man who showed up at her home The questions left unanswered by the Mandelson files Maga influencer Melissa Rein Lively admits Bond Street assault Cara Delevingne on sobriety and mental health inspiring her music Toy Story 5 Tom Hanks says film tackles terror of technology

Morse code transcription: vvv vvv Murdered student Henry Nowak told police I cant breathe while handcuffed The questions left unanswered by the Mandelson files Meta AI chatbot enabled hackers to access others Instagram accounts Maga influencer Melissa Rein Lively admits Bond Street assault Heatwave in Banda A day in the hottest place in India Sabrina Carpenter gets restraining order against man who showed up at her home UK Athletics fined 350,000 over death of Paralympic shot putter at training facility Toy Story 5 Tom Hanks says film tackles terror of technology Peter Murrell used SNP cards for 400,000 spending spree Cara Delevingne on sobriety and mental health inspiring her music

Morse code transcription: vvv vvv How former SNP chief executive Peter Murrell spent the 400,000 he embezzled Bowen Trump needs this war to end but Iran is not backing down London Tube strikes to go ahead as negotiations break down Britains earliest prehistoric art found in Gowers Bacon Hole cave OpenAI let ChatGPT aid and abet mass shooters, Florida suit says Bereft and beleaguered stark criticism revealed in Mandelson messages Weapons obsessed killer Vickrum Digwa jailed for Henry Nowaks murder British woman dies after Pyrenees peak fall River Don searches continue for 11 year old Mackenzie Swift Rosamund Pike calls out audience member for texting during show

Morse code transcription: vvv vvv Weapons obsessed killer Vickrum Digwa jailed for Henry Nowaks murder OpenAI let ChatGPT aid and abet mass shooters, Florida suit says Bereft and beleaguered stark criticism revealed in Mandelson messages Britains earliest prehistoric art found in Gowers Bacon Hole cave Rosamund Pike calls out audience member for texting during show London Tube strikes to go ahead as negotiations break down How former SNP chief executive Peter Murrell spent the 400,000 he embezzled River Don searches continue for 11 year old Mackenzie Swift British woman dies after Pyrenees peak fall Bowen Trump needs this war to end but Iran is not backing down

Morse code transcription: vvv vvv Toy Story 5 Tom Hanks says film tackles terror of technology The questions left unanswered by the Mandelson files Cara Delevingne on sobriety and mental health inspiring her music Meta AI chatbot enabled hackers to access others Instagram accounts UK Athletics fined 350,000 over death of Paralympic shot putter at training facility Heatwave in Banda A day in the hottest place in India Sabrina Carpenter gets restraining order against man who showed up at her home Peter Murrell used SNP cards for 400,000 spending spree Murdered student Henry Nowak told police I cant breathe while handcuffed Maga influencer Melissa Rein Lively admits Bond Street assault

Morse code transcription: vvv vvv Bowen Trump needs this war to end but Iran is not backing down British woman dies after Pyrenees peak fall London Tube strikes to go ahead as negotiations break down Rosamund Pike calls out audience member for texting during show River Don searches continue for 11 year old Mackenzie Swift How former SNP chief executive Peter Murrell spent the 400,000 he embezzled Weapons obsessed killer Vickrum Digwa jailed for Henry Nowaks murder OpenAI let ChatGPT aid and abet mass shooters, Florida suit says Bereft and beleaguered stark criticism revealed in Mandelson messages Britains earliest prehistoric art found in Gowers Bacon Hole cave

A pesar de que anoche Trump se jactó de haber obligado a Benjamin Netanyahu y a Hezbolá a desescalar la situación, hoy los bombardeos israelíes han continuado en diversas zonas del sur libanés, dejando varios muertos, y Hezbolá ha seguido su ofensiva en el norte israelí.Estaremos además en Washington porque Marco Rubio ha comparecido ante una comisión del Senado y ha hablado sobre el conflicto, del que de momento no parece que tengamos noticias positivas. Vamos a escuchar un reportaje sobre GAESA, el oscuro conglomerado empresarial vinculado a la élite cubana en el que se manejan miles de millones de dólares.Estaremos además en Berlín, donde se han reunido el canciller alemán Friedrich Merz y el primer ministro húngaro Peter Magyar. Ambos han mostrado buena sintonía aunque sigue habiendo diferencias en torno a Ucrania, donde la pasada noche Rusia lanzó un durísimo ataque que ha dejado varios muertos en diferentes ciudades del país. Estaremos en Dinamarca para conocer el proyecto del nuevo gobierno de coalición que, tras semanas de intensas negociaciones, liderará la primera ministra Mette Frederiksen, que afronta su 3ª legislatura y es ya una de las líderes danesas que más tiempo estará en el cargo. Daremos cuenta de un informe de la OMM sobre el fenómeno de EL Niño, que se espera especialmente potente este año con las consecuencias que eso acarrea sobre millones de personas de todo el planeta.Viajaremos además al Reino Unido para contarles cómo el exdirector del SNP escocés se gastó más de 450.000 euros del partido en caprichos.Escuchar audio

Well, it seems the big men being laid low is the theme of the moment. Lesley and Fraser are back to discuss a busy week. Lesley has been in all parts, taking in the incredible Orkney Folk Festival and witnessing the seamless infrastructure of the Netherlands, before returning to the rather less seamless Edinburgh Airport. Back in Scotland, the Peter Murrell narrative has been laid out, leaving many in the Yes movement feeling directionless. We look at the abject failure of governance within the SNP. Plus, a look down South at the latest Mandelson revalations.In this episode, we discuss:Orkney and the Netherlands: Lesley reflects on a week of incredible, volunteer-led musicianship at the Orkney Folk Festival. We also compare the well-maintained, cycle-friendly infrastructure of the Netherlands with the sad state of Edinburgh Airport's rolled-up corrugated paper door wedges.Operation Hingaboot Mark II: A large crowd gathered outside Holyrood for the Section 30 request vote. We discuss the ongoing disconnect between the SNP corporate leadership and the grassroots Yes movementPeter Murrell and SNP Governance: Following Peter Murrell's guilty plea, we unpack the agreed narrative of financial mismanagement. We examine the culture of deference that allowed £12,500 of Apple products and a £3,500 silver wine coaster to be coded without curiosity, and how those who tried to raise concerns—like the "Good Guys" slate on the NEC and members of the Finance and Audit Committee—were sidelined and frustrated.Labour's Leaks and Leadership: The latest document dump reveals damning WhatsApp connections between Peter Mandelson and Pat McFadden, who seems to lament the idea of taxing to pay benefits. With Keir Starmer's slow-moving demise, Andy Burnham's by-election date set, and Tony Blair wading into the policy debate, Labour is looking increasingly rudderless.Education and NEETs: Reflecting on Alan Milburn's report on young people not in employment, education, or training. We compare the UK's approach to the Dutch system's high engagement in vocational education and the need for a shift away from traditional, purely academic routes.LinksHighland Clearances; communities fight back - CrowdfunderClearance site event at Rosal on June 12th-14th June ★ Support this podcast ★If you're enjoying the podcast, you can become a pal or a buddy to help keep the pod going by heading to leslieriddock.com/podcast and following the links to subscribe. ★ Support this podcast ★

How can we ensure church money is spent wisely? What are the dangers of leadership structures being influenced? How should we treat junior team members?In this episode of In:Dependence, Phil Topham (FIEC Executive Director), John Stevens (FIEC National Director), and Adrian Reynolds (FIEC Associate National Director) discuss stories in the news from the past weeks and what lessons we can learn from them for church leadership.Show notesLocal Conferences 2026 (FIEC)Leaders' Conference 2026 (FIEC)Rising Lights 2027 (FIEC)We now know how Peter Murrell embezzled from the SNP - but not why (BBC)Mandelson files: What you need to know (BBC)Spygate latest: Southampton boss Tonda Eckert 'loved' information gathered when intern spied on opponent, panel's written reasons reveal (Sky Sports)About In:Dependence: In:Dependence is FIEC's official podcast, where you'll hear conversations on topics for church leaders.Podcast music: Drifting by ⁠⁠⁠⁠⁠⁠⁠⁠⁠Future Infinite⁠⁠⁠⁠⁠⁠⁠⁠⁠.About FIEC: We are ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠a fellowship of Independent churches⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ with members of the family across England, Scotland and Wales. Our mission is to see those Independent churches working together with a big vision: to reach Britain for Christ.00:00 - FIEC update06:21 - Peter Murrell, embezzlement, and where the buck stops17:33 - The Mandelson files and influencing leadership25:34 - Southampton FC spygate and mistreating interns

As Parliament returns from recess, the latest files related to Peter Mandelson's appointment as UK ambassador to the US are due to be released today. How bad could they be for Labour? Tim Shipman joins James Heale to discuss – has the self-styled 'Prince of Darkness' proven to be more a ghost of Christmas past for the government?Plus: Mandelson isn't the only ghost haunting British politics today. Tim and James discuss the ghost of Christmas present, the scandal facing the SNP. Former party treasurer – and husband to Nicola Sturgeon – Peter Murrell pled guilty to charges of embezzlement, prompting the former First Minister to deliver a teary interview to the BBC at the weekend. How believable did they find Sturgeon? And, with two by-elections on the horizon, what consequences could there be for the SNP?Finally: the boys discuss the latest poll showing Trade Union support ebbing away from Labour towards Reform. So – continuing the Dickensian metaphor (sorry) – could this be Labour's very own ghost of Christmas future?Produced by Megan McElroy and Patrick Gibbons.Become a Spectator subscriber today to access this podcast without adverts. Go to spectator.co.uk/adfree to find out more.For more Spectator podcasts, go to spectator.co.uk/podcasts.Contact us: podcast@spectator.co.uk Hosted on Acast. See acast.com/privacy for more information.

Jeremy Kyle examines the latest with the Former First Minister of Scotland Nicola Sturgeon refuses to apologise for Peter Murrell's SNP embezzlement, insisting she bears no responsibility for his crimes. Meanwhile The Prime Minister Sir Keir Starmer faces renewed pressure as Mandelson files threaten further embarrassment over Epstein links, vetting failures, and Labour infighting.Wake up with Talk Breakfast in full on YouTube, DAB+ radio, Samsung TV Plus or the Talk App on your TV from 6am every morning. Hosted on Acast. See acast.com/privacy for more information.

Monday has come around again. Andy and Seán react to Nicola Sturgeon's headline interview with Laura Kuenssberg yesterday in light of her estranged husband's admission to embezzling funds from the SNP, as well as to the news that Twitch streamer Hasan Piker has been barred from entering the UK.Subscribe to How to Rebuild Britain now: https://linktr.ee/howtorebuildbritain Hosted on Acast. See acast.com/privacy for more information.

Julia Hartley-Brewer breaks down what hundreds of bombshell texts, WhatsApps, and emails are expected to reveal about Peter Mandelson's controversial appointment as UK Ambassador to the United States. Also under discussion is Nicola Sturgeon's BBC interview in which she claims to be serving a sentence for a crime she did not commit. Julia and former Conservative government adviser Claire Pearsall question the idea that Sturgeon knew nothing about her husband Peter Murrell embezzling £400,000 from the SNP — including an £80,000 Jaguar, a £125,000 camper van, and 108 loo rolls bought the day before Sturgeon told the nation not to stockpile.Plus: the Hague rules the UK does NOT have to pay Rwanda £100 million. Was the £700 million Rwanda scheme a catastrophic waste of your money?And Tory plans for benefit ration cards for criminals — sensible policy or political fantasy?Then, political commentator James Mathewson joins for a fiery on-air clash over trans rights, Donald Trump, Reform UK, and whether James Murray is a coward for finally admitting that trans women are not women.Julia Hartley-Brewer broadcasts on Talk from Monday to Thursday, 10AM to 1PM. Available on YouTube and streaming platforms, along with DAB+ radio and your smart speaker. Hosted on Acast. See acast.com/privacy for more information.

After Laura's exclusive interview, she's joined by Henry and Joe to discuss what Nicola Sturgeon had to say about her estranged husband Peter Murrell's guilty plea to embezzling hundreds of thousands of pounds from the SNP - as well as the political and public reaction to her words.Hear the full length interview on the previous episode of Newscast.You can now listen to Newscast on a smart speaker. If you want to listen, just say "Ask BBC Sounds to play Newscast”. It works on most smart speakers.You can join our Newscast online community here: https://bbc.in/newscastdiscordGet in touch with Newscast by emailing newscast@bbc.co.uk or send us a WhatsApp on +44 0330 123 9480.New episodes are released every day. If you're in the UK, for more News and Current Affairs podcasts from the BBC, listen on BBC Sounds: https://bbc.in/4guXgXdNewscast brings you daily analysis of the latest political news stories from the BBC.The presenter was Laura Kuenssberg and Joe Pike. It was made by Jon Bithrey with Chloe Scannapieco. The social producer was Joe Wilkinson. The technical producer was Jonathan Greer. The assistant editor is Chris Gray. The senior news editor is Sam Bonham.

It's a controversy which has been hanging over the SNP for years - but on Monday former chief executive, Peter Murrell, admitted to embezzling more than £400,000 from the party. On this episode of Newscast, former first minister Nicola Sturgeon sits down with Laura for her first interview since her estranged husband pleaded guilty. Sturgeon, who was earlier arrested and released without charge, discusses what she knew, defends her handling of concerns about party finances, and describes how the revelations have impacted her personally.If you would like to watch the interview, it's also available on BBC iPlayer.You can now listen to Newscast on a smart speaker. If you want to listen, just say "Ask BBC Sounds to play Newscast”. It works on most smart speakers.You can join our Newscast online community here: https://bbc.in/newscastdiscordGet in touch with Newscast by emailing newscast@bbc.co.uk or send us a WhatsApp on +44 0330 123 9480.New episodes released every day. If you're in the UK, for more News and Current Affairs podcasts from the BBC, listen on BBC Sounds: https://bbc.in/4guXgXdNewscast brings you daily analysis of the latest political news stories from the BBC. The presenter was Laura Kuenssberg. It was made by Laurie Kalus and Paul Twinn. The planning producer was Chris Flynn. The technical producer was Jonathan Greer. The assistant editor is Chris Gray. The senior news editor is Sam Bonham.

Morse code transcription: vvv vvv Canadian man who allegedly sold lethal chemical will not be tried in UK No second retrial for men accused of Manchester Airport brawl EU hails Hungarys wind of change and unlocks 16.4bn for new PM Magyar Nato condemns Russian recklessness after drone hits Romanian apartment block Blue Origin rocket explosion could damage Nasas Moon timetable Trump holds meeting to make final determination on Iran deal Pair jailed over 139mph fatal crash in 30 zone Sturgeon wishes she had not kept Murrell on as SNP chief executive Child among three dead after south London tower block fall French Open 2026 results Novak Djokovic beaten by Joao Fonseca in third round thriller

Guests include former Welsh government minister Lee Waters on the future of transport in Wales, political commentator and podcaster Lesley Riddoch and political scientist, Professor Sir John Curtice, on the future of the SNP after the Murrell crisis. Blair expert (he teaches a course on aspects of the Blair governments) and chief political commentator John Rentoul discusses the intervention by former PM, Sir Tony Blair, on the future of the party and Cold War historian Sergey Radchenko considers the political impact of a Russian drone hitting an apartment block in NATO country, Romania. And in the week when we've experienced record temperatures, Professor Bill McGuire looks at what the climate might be like in the 2050s. And in our regular series of introducing you to new politicians in the Senedd, we hear from Labour MS Shavannah Taj about the impact that her family and her teachers had on her politics

Morse code transcription: vvv vvv Sturgeon wishes she had not kept Murrell on as SNP chief executive No second retrial for men accused of Manchester Airport brawl Child among three dead after south London tower block fall Blue Origin rocket explosion could damage Nasas Moon timetable EU hails Hungarys wind of change and unlocks 16.4bn for new PM Magyar Pair jailed over 139mph fatal crash in 30 zone Canadian man who allegedly sold lethal chemical will not be tried in UK French Open 2026 results Novak Djokovic beaten by Joao Fonseca in third round thriller Trump holds meeting to make final determination on Iran deal Nato condemns Russian recklessness after drone hits Romanian apartment block

Morse code transcription: vvv vvv No second retrial for men accused of Manchester Airport brawl Sturgeon wishes she had not kept Murrell on as SNP chief executive Pair jailed over 139mph fatal crash in 30 zone Nato condemns Russian recklessness after drone hits Romanian apartment block Blue Origin rocket explosion could damage Nasas Moon timetable EU hails Hungarys wind of change and unlocks 16.4bn for new PM Magyar Child among three dead after south London tower block fall Canadian man who allegedly sold lethal chemical will not be tried in UK French Open 2026 results Novak Djokovic beaten by Joao Fonseca in third round thriller Trump holds meeting to make final determination on Iran deal

Ian Collins reacts as Youth worklessness dominates tonight, as Milburn warns one million young Britons are now outside education, employment or training. New analysis from The Centre for Social Justice links the crisis to rising non-EU recruitment, especially in retail and hospitality entry-level roles. Meanwhile, Nicola Sturgeon says Peter Murrell's SNP embezzlement admission has left her betrayed, deceived, and publicly engulfed.Wake up with Talk Breakfast in full on YouTube, DAB+ radio, Samsung TV Plus or the Talk App on your TV from 6am every morning. Hosted on Acast. See acast.com/privacy for more information.

You can watch this episode on YouTube: https://youtu.be/uXkk5GHpPE4This week on Planet Normal, your co-pilots of sanity, Liam Halligan and Allison Pearson, dive into a political landscape dominated by explosive leadership interventions and growing institutional scandal. Following a dramatic local election period, the duo analyzes a scathing 5,000-word essay by former Prime Minister Tony Blair, who has openly lacerated his own party for what he calls an “infinite capacity for self-delusion”.Liam details the escalating fiscal warning signs rattling the British establishment. He warns that despite a temporary dip in the UK inflation rate to 2.8%, it is on track to hit 5% later this year. With long-term government borrowing costs flirting with 30-year highs, Liam argues that cosmetic fixes like supermarket price controls and rollercoaster VAT cuts will do nothing to soothe terrified sovereign bond markets.Meanwhile Allison shares her assessment of the Scottish National Party following the sensational embezzlement guilty plea of its former chief executive. This week's stowaway on the rocket is serial entrepreneur and hospitality titan Luke Johnson, who shares a powerful breakdown of how Britain is currently navigating life under what he defines as a “highly damaging socialist government”.HighlightsBlair is talking sense on this Lefty Labour Party, and Starmer should listen to save themSir Keir Starmer faces mounting threats to his leadership as ideological factions fracture the Labour Party.Looming fiscal disaster deepens as the UK inflation rate is projected to climb back toward 5%.The SNP establishment faces total mockery following the sensational embezzlement fallout of its leadership.Sign up to our most popular newsletter, From the Editor. Look forward to receiving free-thinking comment and the day's biggest stories, every morning. telegraph.co.uk/fromtheeditor |Book your tickets to 'How to make Brexit a success' on 29th June in London: telegraph.co.uk/brexit-big-debate |Read Allison ‘Did you really not know about your husband, Nicola?':https://www.telegraph.co.uk/news/2026/05/26/allison-pearson-nicola-sturgeon-husband/ |Read more from Allison: https://www.telegraph.co.uk/authors/a/ak-ao/allison-pearson/ | Read Liam ‘The approaching inflation crisis is a disaster for Labour': https://www.telegraph.co.uk/business/2026/05/24/the-approaching-inflation-crisis-is-a-disaster-for-labour/ |Read more from Liam: https://www.telegraph.co.uk/authors/liam-halligan/ |Read Liam's Substack: https://liamhalligan.substack.com/ |Need help subscribing or reviewing? Learn more about podcasts here:https://www.telegraph.co.uk/radio/podcasts/podcast-can-find-best-ones-listen/ |Email: planetnormal@telegraph.co.uk |For 30 days' free access to The Telegraph: https://www.telegraph.co.uk/normal | Hosted on Acast. See acast.com/privacy for more information.

Peter Murrell, the SNP's former chief executive and Nicola Sturgeon's estranged husband, has admitted embezzling £400,000 in party funds. The guilty plea has revived questions about what senior figures in the SNP knew, how long the scandal had been going on, and what happens next. To discuss the story, including some of the ridiculous purchases including a couple of hairdryers (for a bald man) and £2600 salt and pepper shakers, James Heale and Michael Simmons join Megan McElroy.Become a Spectator subscriber today to access this podcast without adverts. Go to spectator.co.uk/adfree to find out more.For more Spectator podcasts, go to spectator.co.uk/podcasts.Contact us: podcast@spectator.co.uk Hosted on Acast. See acast.com/privacy for more information.

Peter Murrell's mafia-style SNP & could the Reform-Restore feud hand Burnham Makerfield?This week: the Peter Murrell scandal and the collapse of the SNP's moral authority. After Nicola Sturgeon's estranged husband and the party's former chief executive pleaded guilty to embezzling more than £400,000 from SNP funds, Michael and Madeline ask what this reveals about the party that dominated Scottish politics for more than a decade. Was this simply one man's disgrace – or a symptom of a political machine that had grown too powerful, too closed and too complacent?Also on the podcast: the growing split on the right. As Rupert Lowe's Restore threatens to divide the Reform vote in the Makerfield by-election, could Andy Burnham be saved by a battle between Nigel Farage and his former allies?And finally: the rise of the well-worriers. From Zoe and Oura rings to sleep scores, glucose monitors and heart-rate variability, the middle classes are no longer just trying to be healthy – they are trying to measure every flicker of human existence. Is all this self-tracking making us fitter, or just more neurotic? Hosted on Acast. See acast.com/privacy for more information.

The former SNP chief executive has admitted embezzling more than £400,000 from the party between August 2010 and October 2022, using the money to buy jewellery, cosmetics and a motorhome. Adam Fleming and Alex Forsyth chat it all through with Patrick Maguire from The Times, in front of an audience at Hay Festival. You can now listen to Newscast on a smart speaker. If you want to listen, just say "Ask BBC Sounds to play Newscast”. It works on most smart speakers. You can join our Newscast online community here: https://bbc.in/newscastdiscord Get in touch with Newscast by emailing newscast@bbc.co.uk or send us a WhatsApp on +44 0330 123 9480. New episodes released every day. If you're in the UK, for more News and Current Affairs podcasts from the BBC, listen on BBC Sounds: https://bbc.in/4guXgXd Newscast brings you daily analysis of the latest political news stories from the BBC. The hosts were Adam Fleming and Alex Forsyth. It was made by Anna Harris. The social producer was Jem Westgate. The technical producers were Lewis Allsopp and Darren Wardrobe. The assistant editor is Chris Gray. The senior news editor is Sam Bonham.