Podcasts about SNP

For our third summer EMQs we're returning to our What Ifs. Ed Balls and George Osborne first consider how Britain would change had they never entered politics? Would the Bank of England become independent? Would there be a Manchester mayoralty? Or, would it have had no impact?What if George got the US Ambassador gig over Peter Mandelson? The pair consider how George would approach the job differently, blowback from within Labour, and whether Keir Starmer would still be in post without the controversy of Mandelson. They then go back in time to February 1974, where a hung Parliament saw Labour form a minority government. What if negotiations between the Conservatives and Liberals panned out? How long would this coalition survive? Would it stop Margaret Thatcher becoming PM? Who leads Labour after Harold Wilson? Finally, what if Labour were the largest party in 2015? If it's a hung Parliament who do they go into coalition with? Can they work with the SNP? Does it stop Brexit? What happens with the Tories and UKIP?We love hearing from you, so please don't forget to send all your EMQs to questions@politicalcurrency and make sure to include a voice note of your question or send a question to our social media handles:

Either Michael Marra or Joe Fagan will be the next leader of the Scottish Labour Party. What's happening in the race, what does the new leader need to do and will it make any difference in their goal of Labour unseating the SNP?PLUS - It's reported the John Swinney's World Cup junket with entourage cost the tax payer around £95k? Was it worth it?Anger in Glasgow over the state of the City. Why can't opposition parties hold the SNP to account?Focussing on UK, Scottish and Global politics, if you like other great political podcasts like The Rest is Politics, The News Agents, Newscast, Questions Time, Holyrood Sources, Planet Holyrood, The Stooshie, The Steamie, Scotcast, Americast etc etc then The Ponsonby and Massie Podcast could be a great show to add to your list of favourites. Hosted on Acast. See acast.com/privacy for more information.

Joanna Cherry joins us this week to discuss her newly published memoir, in which she looks back on some of the most contentious battles in British and Scottish politics in the last two decades. She arrived at Westminster in 2015 as one of 56 SNP MPs elected in a historic landslide that transformed Scottish politics and made the SNP the third-largest party in the House of Commons. She describes the excitement – and occasional hostility – that greeted the new contingent and explains why her experience at Westminster left her believing that the Scottish Parliament could learn a lot from the Commons, particularly when it comes to cross-party working, debate, dissent, and committee scrutiny. One of the central arguments of Cherry's memoir is that the SNP repeatedly failed to exploit moments of political leverage and that it pursued the wrong strategy for securing another Scottish independence referendum after the loss in 2014. She sets out what she thinks the party could have done differently and why she believes support for independence has now become increasingly detached from support for the SNP itself. Her national profile grew dramatically during the Brexit years. As a constitutional lawyer, Cherry became the lead petitioner in the Scottish legal challenge to Boris Johnson's 2019 prorogation of Parliament. She explains why the case was brought in Scotland, why she believed the challengers would ultimately win, and what it felt like when the Supreme Court unanimously ruled the prorogation unlawful. The conversation also turns to the bitter internal disputes that marked Cherry's later years in the SNP. She discusses her relationship with Nicola Sturgeon, her concerns about the SNP's governance and finances, the treatment of her former mentor Alex Salmond, and the fierce arguments over reform of Scotland's gender recognition laws. Having lost her seat at Westminster in 2024 and subsequently left the SNP, is Joanna Cherry finished with frontline politics? Perhaps not. She doesn't rule out a return under a new party leader and a new culture of independent thinking.

One of the SNP's top talents, Stephen Flynn is on hilarious form at the Edinburgh Festival.He opens up about his frustrations with Nicola Sturgeon's critique of the SNP campaign and exclusively reveals that he'd already resigned as SNP Leader in Westminster BEFORE the 2024 general election had been called. Stephen's got great stories about small talk with ex-Prime Ministers at the Cenotaph as well as his experiences from his summer travelling across the USA with the Tartan Army at the World Cup.It's clear to see why he's so highly regarded, especially as he had to overcome major health problems in his youth.This is a story of resilience, determination. And football. See the Political Party Live on Stage:18 August: Douglas Alexander (Edinburgh)20 August: Malcolm Offord (Edinburgh)9 November: Liz Kendall (London)21 December: Wes Streeting (London) GET TICKETS for Matt's brand new stand-up show Project Holy Moly at the Edinburgh Festival and touring nationwide in 2027:www.mattforde.comMARCH19 FAVERSHAM The Alex20 DORKING HallsAPRIL7 STOURBRIDGE Town Hall8 GLOUCESTER Guildhall9 LEICESTER Y Theatre12 SALFORD Lowry16 NORTHAMPTON Royal & Derngate21 EXETER Northcott Theatre24 LONDON Bloomsbury Theatre28 ALNWICK Playhouse29 BARNARD CASTLE Witham30 HULL AsylumMAY6 BIRMINGHAM The Glee Club12 COVENTRY Warwick Arts Centre13 WORCESTER Huntingdon Hall14 CHORLEY Theatre18 STAMFORD Corn Exchange19 SHEFFIELD Steamworks20 SHREWSBURY Theatre Severn21 NOTTINGHAM Theatre Royal23 LEEDS City Varieties Music Hall26 NORWICH Playhouse27 NORWICH PlayhouseJUNE2 SCUNTHORPE Plowright4 CANTERBURY Gulbenkian Theatre5 READING Concert Hall8 CARDIFF The Glee Club9 BATH Komedia10 MONMOUTH Savoy Theatre11 CHIPPING NORTON The Theatre15 BURY ST EDMUNDS Theatre Royal16 MILTON KEYNES The Stables18 TUNBRIDGE WELLS Trinity Theatre30 LIVERPOOL Everyman PlayhouseJULY1 CARLISLEOld Fire Station2 GLASGOW The Glee Club4 EDINBURGH Lyceum Theatre Hosted on Acast. See acast.com/privacy for more information.

Sverige är idag en del av Natos och Frankrikes strategi för kärnvapenavskräckning. Vad innebär det för oss... egentligen? Lyssna på alla avsnitt i Sveriges Radios app. Europa visar upp sina kärnvapenförmågor som ett svar på ryska hot och USA:s ökade ointresse. Konflikts reportrar ger sig ut på en resa till Västeuropas två kärnvapennationer Frankrike och Storbritannien. Vi rör oss bland toppolitiker i Paris medan kärnvapenkapabla Rafale-stridsflybland dundrar över staden. Och tar oss längst in i en skotsk fjord där Storbritanniens kärnvapenflotta finns. Medverkande: Catherine Vautrin, Frankrikes försvarsminister, Pål Jonsson, Sveriges försvarsminister, överste Edward Hallenborg som fram till nyligen jobbat med kärnvapenavskräckning på Försvarshögkvarterets strategienhet, Julie Decarpentrie, forskare med kärnvapenfokus vid Försvarshögskolan, Darya Dolzikova, analytiker och kärnvapenexpert vid institutet RUSI i Storbritannien, David Kelley, pensionerad IT-ingenjör i Glasgow, Isabel Lindsey, 82-årig brittisk tidigare politiker för Scottish National Party och anti-kärnvapenaktivist, Cara McKee, skotsk miljöpartistisk politiker, Paul McLennan, skotsk tidigare minister för nationalistpartiet SNP som samordnar de skotska partierna i kampen mot kärnvapen på skotsk mark mflAvsnittet görs av: Anja Sahlberg och Ulrika Bergqvistanja.sahlberg@sr.se ulrika.bergqvist@sr.seTekniker: Calle Hedlund

Managing High Homocysteine with MTHFR Variants and the Role of Vitamin C in Brain Aging: Registered dietitian nutritionist Leyla Muedin discusses MTHFR genetic variants (C677T and A1298C), their links to impaired methylation, homocysteine, SAMe, mood issues, migraines, vitamin deficiencies, and pregnancy complications, noting many people are asymptomatic and some feel worse on methylated B vitamins and do better on standard formulations. Responding to a listener with C677T, high homocysteine, and borderline methylmalonic acid, she reviews optimal homocysteine targets and outlines other causes of elevated homocysteine such as hypothyroidism/subclinical hypothyroidism, kidney failure, obesity, hypertension, diabetes, smoking, inactivity, and medications (atorvastatin, methotrexate, fenofibrate). She suggests checking these factors, considering absorption issues (intrinsic factor) for B12, and trialing SAMe and more trimethylglycine, with possible pharmacologic folate if needed. She then summarizes an observational Japanese study (n=2,044 adults >64) linking lower plasma vitamin C to reduced gray matter and weaker default mode network connectivity, and notes diet and blood sugar can affect vitamin C status.

In the lead-up to Bryan Kohberger's trial, some of the most consequential legal fighting centered on the DNA recovered from the knife sheath found beneath Madison Mogen's body and the investigative genetic genealogy, or IGG, process that investigators used to identify Kohberger as a suspect. Authorities had extracted a single-source male DNA profile from the sheath and later sent the sample to Othram, which developed a SNP profile that could be compared against genealogy databases that permitted law-enforcement searches. Investigators used that information to build family trees that eventually pointed toward Kohberger, after which authorities collected trash from his family's Pennsylvania home and obtained DNA that helped connect his family to the sheath sample. Kohberger's defense spent years seeking the underlying IGG records, laboratory materials, family-tree information and details about how Othram and the FBI conducted the genealogy work. That discovery fight produced multiple motions to compel, closed hearings and court-ordered disclosures under seal as the defense argued that it needed the material to examine whether the investigative process had been scientifically reliable and constitutionally permissible.The fight eventually moved from obtaining the evidence to trying to keep it out of court altogether. Kohberger's attorneys argued that law enforcement had violated his constitutional rights by conducting the IGG investigation without a warrant and by later obtaining DNA through a trash pull at his parents' home, contending that evidence developed from those steps and subsequent warrants should be suppressed as fruit of an unlawful search. Judge Steven Hippler rejected that argument in February 2025, ruling that Kohberger had not established a constitutionally protected privacy interest that made the IGG process or abandoned trash unlawful searches and declining to suppress the resulting evidence. The defense then continued attacking the genealogy evidence through motions in limine, arguing that the State should not be permitted to present the IGG process to the jury and raising separate challenges involving terminology such as “touch” or “contact” DNA and the disclosure of expert testimony. The State maintained that IGG had primarily been an investigative lead rather than the evidentiary foundation of its case, while prosecutors intended to rely on the direct comparison between Kohberger's DNA and the profile recovered from the sheath. By the time trial approached, the DNA battle had therefore become two interconnected fights: whether the genetic genealogy that led investigators to Kohberger had been lawfully conducted, and exactly how much of that complicated investigative history the jury would ultimately be allowed to hear.to contact me:bobbycapucci@protonmail.com

There is a limited amount of DNA left from under Maggie Murdaugh's left hand, and both sides want to test it first. Tony Brueski takes your questions on that fight with retired FBI Special Agent Robin Dreeke.SLED previously determined the material belonged to an unknown, unrelated male, but did not identify him. The state uses STR analysis, which checks samples against law enforcement databases and cannot name someone who is not already in the system. The defense wants the reserve samples sent first to Othram, a Texas laboratory that runs SNP testing and forensic genetic genealogy, the approach that can build out a family tree from an unknown contributor.In a July filing, Murdaugh's attorneys told the court something new. Prosecutors had just disclosed that reserve samples from two evidence items remain unprocessed, and that SLED wants to run repeat testing on them. Every test consumes material. The defense argues a retest risks exhausting the only sample capable of producing a name. Othram, they say, could finish in sixty to ninety days.The same filing accuses SLED of mishandling the white T-shirt Murdaugh wore the night of the killings. Testing returned negative for human blood on the stained areas, and the shirt was later rendered unavailable for additional testing after a chemical enhancement agent was applied. The defense calls that a reason to doubt the agency's good faith. That is their allegation, not a court finding.Prosecutors oppose the defense's access request. Judge Debra McCaslin decides the sequence. A July conference on the testing brought defense attorneys, prosecutors, SLED forensic scientists and Othram's chief executive into the same call.The verdicts against him were reversed on appeal, and Murdaugh returns to trial presumed innocent. Robin Dreeke takes the mail on what a name under those fingernails would and would not prove.END LINKSJoin Our SubStack For AD-FREE ADVANCE EPISODES & EXTRAS!: https://hiddenkillers.substack.com/ Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/channel/UC8-vxmbhTxxG10sO1izODJg?sub_confirmation=1 Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/TrueCrimePodDISCLAIMERThis publication contains commentary and opinion based on publicly available information. All individuals are presumed innocent until proven guilty in a court of law. Nothing published here should be taken as a statement of fact, health or legal advice.HASHTAGS#AlexMurdaugh #MurdaughRetrial #HiddenKillers #SLED #BradyMotion #MaggieMurdaugh #DickHarpootlian #TrueCrime #MurdaughMurders #SouthCarolina

In the lead-up to Bryan Kohberger's trial, some of the most consequential legal fighting centered on the DNA recovered from the knife sheath found beneath Madison Mogen's body and the investigative genetic genealogy, or IGG, process that investigators used to identify Kohberger as a suspect. Authorities had extracted a single-source male DNA profile from the sheath and later sent the sample to Othram, which developed a SNP profile that could be compared against genealogy databases that permitted law-enforcement searches. Investigators used that information to build family trees that eventually pointed toward Kohberger, after which authorities collected trash from his family's Pennsylvania home and obtained DNA that helped connect his family to the sheath sample. Kohberger's defense spent years seeking the underlying IGG records, laboratory materials, family-tree information and details about how Othram and the FBI conducted the genealogy work. That discovery fight produced multiple motions to compel, closed hearings and court-ordered disclosures under seal as the defense argued that it needed the material to examine whether the investigative process had been scientifically reliable and constitutionally permissible.The fight eventually moved from obtaining the evidence to trying to keep it out of court altogether. Kohberger's attorneys argued that law enforcement had violated his constitutional rights by conducting the IGG investigation without a warrant and by later obtaining DNA through a trash pull at his parents' home, contending that evidence developed from those steps and subsequent warrants should be suppressed as fruit of an unlawful search. Judge Steven Hippler rejected that argument in February 2025, ruling that Kohberger had not established a constitutionally protected privacy interest that made the IGG process or abandoned trash unlawful searches and declining to suppress the resulting evidence. The defense then continued attacking the genealogy evidence through motions in limine, arguing that the State should not be permitted to present the IGG process to the jury and raising separate challenges involving terminology such as “touch” or “contact” DNA and the disclosure of expert testimony. The State maintained that IGG had primarily been an investigative lead rather than the evidentiary foundation of its case, while prosecutors intended to rely on the direct comparison between Kohberger's DNA and the profile recovered from the sheath. By the time trial approached, the DNA battle had therefore become two interconnected fights: whether the genetic genealogy that led investigators to Kohberger had been lawfully conducted, and exactly how much of that complicated investigative history the jury would ultimately be allowed to hear.to contact me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-moscow-murders-and-more--5852883/support.

This is an exclusive, the first interview Anas has given since becoming a Minister and a Lord.No stone is unturned as he tells us:What really happened when he called on Keir Starmer to resign.Why Scottish Labour lost so badly.Why he believes there are still legitimate questions the SNP must answer about the party finances...And so much more. It's packed. Best enjoyed with a black coffee...See the Political Party Live on Stage:15 August: Stephen Flynn (Edinburgh)18 August: Douglas Alexander (Edinburgh)20 August: Malcolm Offord (Edinburgh)9 November: Liz Kendall (London)21 December: Wes Streeting (London) GET TICKETS for Matt's brand new stand-up show Project Holy Moly at the Edinburgh Festival and touring nationwide in 2027:www.mattforde.comMARCH19 FAVERSHAM The Alex20 DORKING HallsAPRIL7 STOURBRIDGE Town Hall8 GLOUCESTER Guildhall9 LEICESTER Y Theatre12 SALFORD Lowry16 NORTHAMPTON Royal & Derngate21 EXETER Northcott Theatre24 LONDON Bloomsbury Theatre28 ALNWICK Playhouse29 BARNARD CASTLE Witham30 HULL AsylumMAY6 BIRMINGHAM The Glee Club12 COVENTRY Warwick Arts Centre13 WORCESTER Huntingdon Hall14 CHORLEY Theatre18 STAMFORD Corn Exchange19 SHEFFIELD Steamworks20 SHREWSBURY Theatre Severn21 NOTTINGHAM Theatre Royal23 LEEDS City Varieties Music Hall26 NORWICH Playhouse27 NORWICH PlayhouseJUNE2 SCUNTHORPE Plowright4 CANTERBURY Gulbenkian Theatre5 READING Concert Hall8 CARDIFF The Glee Club9 BATH Komedia10 MONMOUTH Savoy Theatre11 CHIPPING NORTON The Theatre15 BURY ST EDMUNDS Theatre Royal16 MILTON KEYNES The Stables18 TUNBRIDGE WELLS Trinity Theatre30 LIVERPOOL Everyman PlayhouseJULY1 CARLISLE Old Fire Station2 GLASGOW The Glee Club4 EDINBURGH Lyceum Theatre Hosted on Acast. See acast.com/privacy for more information.

THE CENSORS' THREAT TO ARTIn his latest Lowdown podcast, Nick Cohen talks to Sally Gimson, editor of Index on Censorship, discussing her report on censorship and the lack of political drama in the British arts scene. Sally explains that despite a strong left-wing political passion in the arts, there is a dearth of political theatre, with institutions playing it safe to avoid controversy. She describes how plays are now heavily workshopped and censored by committees, leading to bland and inoffensive productions. Sally highlights specific examples, such as the canceled production of A Midsummer Night's Dream at the Royal Exchange in Manchester, which was deemed too political. Nick and Sally also discuss the chilling effect of funding dependencies, such as deals with China, and political pressures, particularly in Scotland where the SNP's dominance has stifled satire. Sally concludes with a critique of the self-censorship and institutional timidity that is rendering the arts irrelevant and apolitical.Read all about it!@SallyGimson is editor of @IndexCensorship, aTrustee of Abortion Talk. Sally's Fabian pamphlet Building Bridges in the wake of the Labour Party's 2019 defeat on what it needed to enhance its futjure election chances https://fabians.org.uk/publication/building-bridges/ was published in 2020.Nick Cohen's @NichCohen4 regular Substack column Writing from London on politics and culture from the UK and beyond is another must-read. Hosted on Acast. See acast.com/privacy for more information.

What's going on? Former SNP FM Nicola Sturgeon criticising John Swinney's SNP? Is this a serious analysis or part of the latest round of book promotion?The SNP hit back saying John Swinney is the best First Minister yet. Also, the race for the Scottish Labour leadership is warming up. Michael Marra looks like the front runner with Joe Fagan also in contention but Monica Lennon may struggle to get the required nominations to stand in the vote. Bernard Ponsonby and Alex Massie discuss. Focussing on UK, Scottish and Global politics, if you like other great political podcasts like The Rest is Politics, The News Agents, Newscast, Questions Time, Holyrood Sources, Planet Holyrood, The Stooshie, The Steamie, Scotcast, Americast etc etc then The Ponsonby and Massie Podcast could be a great show to add to your list of favourites. Hosted on Acast. See acast.com/privacy for more information.

Nicola Sturgeon faces fierce backlash from her own former cabinet colleagues after criticising the SNP's election strategy in a new book foreword. Calum Macdonald, Geoff Aberdein and Andy Maciver break down the response from the First Minister and Cabinet Secretaries.Plus, as the Scottish Labour leadership contest opens with Monica Lennon, Michael Marra, and Joe Fagan announcing their leadership, we ask: what is Labour's long-term plan to challenge the SNP, is there any possibility of a party win in 2031?Later, we revisit Scotland's income tax debate. Economist Laurie Macfarlane (Co-Director of Future Economy Scotland) responds to Dan Neidle's analysis on Scotland's 48p top tax rate. Does the data really show a £22m loss, or are volatility and broader economic factors being overlooked? Hosted on Acast. See acast.com/privacy for more information.

Nicola Sturgeon has been accused of being "more Green than SNP" after the former first minister blasted John Swinney's election campaign strategy. The Record's Chris McCall is joined by John Ferguson of the Sunday Mail and Douglas Dickie of the Scottish Daily Express. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Join the SNP crew this Thursday at 6.30pm PT / 9.30pm ET to review the second episode of Star Trek Strange New Worlds season  4 : The Griffin Incident written by Robbie Thompson and directed Axelle Carolyn. √ SUPPORT» Patreon https://patreon.com/strangenewpod» Kofi https://ko-fi.com/strangenewpod√ FOLLOW» Instagram https://instagram.com/strangenewpod» Thread https://www.threads.net/@strangenewpod» Blue Sky https://bsky.app/profile/strangenewpod.bsky.social√ THE CREW» Giraffe https://instagram.com/lyrical_girafe/» Erik https://instagram.com/erikactingout/» Emcee https://instagram.com/emceefrodis/» Hawk https://instagram.com/thehawk1701d/√ STAY IN TOUCH» Discord https://discord.gg/WJPXGBXbu» Website www.strangenewpod.com» Email astrangenewpod@gmail.comMusicDiscovery by Scott Buckley | scottbuckleyMusic promoted by https://www.free-stock-music.comAttribution 4.0 International (CC BY 4.0)#StarTrek #StrangeNewWorlds #StarTrekStrangeNewWorlds #SNW #ParamountPlus #PodcastSend us Fan MailSupport the show

Contact us and share your opinioneGPlearning News Update | New Health Secretary, BMA Collective Action & Ambient Voice Tech GuidanceIn this episode, we break down the latest news affecting primary care and general practice in the UK. We cover the appointment of the new Health & Social Care Secretary, updates on BMA collective action steps for August, calls from grassroots GP groups, and newly released official guidance on Ambient Voice Technology (AVT).

Contact us and share your opinionFill in this form on MNP and SNPs : https://www.engage.england.nhs.uk/con...00:00 Back from a break01:49 MNP and SNP contracts05:20 Contract details14:27 MNP - Multi-Neighbourhood Provider Contracts25:20 SNP - Single Neighbourhood Provider Contracts32:30 PCNs change to SNPs37:45 Commissioning other services39:26 GP Share your views on new contracts42:20 Comments43:25 Our views on new contracts46:30 Dr Clare Bannon New GPC chair 49:50 New GPC chair agenda01:00:30 AVT procurement01:03:01 SummaryA consultation on proposed Multi-Neighbourhood Provider (MNP) and Single Neighbourhood Provider (SNP) contracting models to support neighbourhood health serviceshttps://www.engage.england.nhs.uk/con... The new GPC chair is asking a question few GP leaders have dared to askhttps://www.pulsetoday.co.uk/views/ed... Midlands leads the way on ambient voice technologyhttps://www.england.nhs.uk/midlands/2...Join Dr Mike as he shares how to get started and fly using EMIS to make your life easier with this clinical systembit.ly/EMIScourse

Episode: 00327 Released on July 13, 2026 Description:  Investigative genetic genealogy is helping solve cold cases, identify unknown victims, and generate leads that traditional investigative methods could not uncover. But where do law enforcement analysts fit into this rapidly evolving field? In the inaugural episode of LEAN (Law Enforcement Analysis Networks), host Jason Elder speaks with Christine Fiechter and Kimm Barnes of the newly formed Investigative Genetic Genealogy Association (IGGA). Christine and Kimm explain the fundamentals of investigative genetic genealogy, how DNA matches and family trees are used to develop investigative leads, and some of the common misconceptions surrounding the practice. They introduce IGGA's mission and its three pillars of education, networking, and professionalism while discussing the association's role in bringing together professionals from law enforcement, genealogy, forensic science, academia, and the private sector. The conversation also explores opportunities for law enforcement analysts to enter the IGG field, training pathways, gaining leadership support, the advantages and challenges faced by smaller agencies, and the evolving legal and ethical landscape surrounding IGG. Whether you are already working with investigative genetic genealogy or simply curious about where your analytical skills could take you next, this episode demonstrates why analysts may already possess one of the most important IGG skills: the ability to connect the dots. LEAN (Law Enforcement Analysis Networks) is a recurring Analyst Talk series connecting analysts with the professional associations, communities, and networks that can support their careers and professional growth. Each LEAN episode introduces an organization of interest to the law enforcement analysis profession, explores what it does and who it serves, and highlights opportunities for analysts to learn, connect, contribute, and get involved.  

Joining Iain Dale on Cross Question are Labour MP Miatta Fahnbulleh - whose resignation helped triggered Sir Keir Starmer's resignation, the Conservatives' Shadow Business Secretary Andrew Griffith, the SNP's Westminster leader Dave Doogan, plus the journalist and broadcaster Angela Epstein.

What does this country need to do to shut down the questions over the Falkland Islands' sovereignty for good?Joining Iain Dale on Cross Question are Labour MP Miatta Fahnbulleh - whose resignation helped triggered Sir Keir Starmer's resignation, the Conservatives' Shadow Business Secretary Andrew Griffith, the SNP's Westminster leader Dave Doogan, plus the journalist and broadcaster Angela Epstein.

With SNW 4 right on the horizon, it  is time for a SNW 3 refresher ! Before Season 4 warps onto our screens, we're looking back at Star Trek: Strange New Worlds Season 3 one last time. Which episodes earned a toot? Which ones get the boot? What deserves a permanent place in Trek lore, and what would we happily send into the memory hole? Join the SNP crew as we revisit the season, debate our hottest takes, and decide what truly stood the test of time.√ SUPPORT» Patreon https://patreon.com/strangenewpod»  Kofi https://ko-fi.com/strangenewpod√ FOLLOW» Instagram https://instagram.com/strangenewpod» Thread https://www.threads.net/@strangenewpod» Blue Sky https://bsky.app/profile/strangenewpod.bsky.social√ THE CREW» Giraffe https://instagram.com/lyrical_girafe/» Erik https://instagram.com/erikactingout/» Emcee https://instagram.com/emceefrodis/» Hawk  https://instagram.com/thehawk1701d/√ STAY IN TOUCH» Discord https://discord.gg/WJPXGBXbu»  Website www.strangenewpod.com»  Email astrangenewpod@gmail.comSend us Fan MailSupport the show

We are delighted that Patrick Harvie, long-serving Scottish Greens MSP and former Co-Leader of the party joined Stuart Cosgrove on this edition of Talk Media. They talked about a range of fascinating subjects and this is the only place that you'll find out what Patrick and Lorna Slater did after they stormed out of Bute House on that fateful day when their relationship with Humza Yousaf and the SNP fell apart. Independent media analysis is harder than ever. Our supporters allow us to stay forensic and un-influenced. Ad-free listening Supporters-only episodes weekly Monthly special episode Early access to weekly episodes (on day of recording) Supporters chat community on Patreon Discounts for live show tickets Weekly recommendations Join monthly for £3.96 per month - cancel anytime Join today: ⁠thebiglight.com/talkmedia Learn more about your ad choices. Visit megaphone.fm/adchoices

Is Britain really as free of corruption as we think? This year the UK posted its lowest-ever score in a global corruption index. High-level scandals like Peter Mandelson's Epstein ties and Peter Murrell embezzling from the SNP – and less conspicuous instances of fraud and backhanders – are eating into our self-image as rule-followers. And the man who might be Prime Minister keeps changing his explanation for a £5m gift from a crypto baron. Are these isolated political crises, or does the rot in our system run deeper? Professor of anti-corruption practice at the University of Sussex Robert Barrington joins Zing Tsjeng to unpick how corruption manifests in Britain. • Buy Robert's book Corrupted Kingdom: Britain's Disappearing Integrity – And How We Can Get It Back from our affiliate bookshop and you'll help fund the podcast by earning us a small commission for every sale. Bookshop.org's fees help support independent bookshops too.• Special offer! Get 20% off any vehicle history check at carVertical.com/TheBunker.• Back us on Patreon – www.patreon.com/bunkercastWritten and presented by Zing Tsjeng. Producer: James Liddell. Audio production: Jade Bailey. Managing Editor: Jacob Jarvis. Group Editor: Andrew Harrison. Music by Kenny Dickinson. THE BUNKER is a Podmasters Production.www.podmasters.co.uk Hosted on Acast. See acast.com/privacy for more information.

It's a week of breaking press conferences and transatlantic sporting drama. This week, Lesley and Fraser try to find their feet amidst a fast-moving political news cycle, broadcasting through recycling collection interruptions and unexpected announcements. From Donald Trump's latest ego-driven phone call to FIFA to Nigel Farage's high-stakes scramble over undeclared cash and property portfolios, we unpack the creeping Americanisation and deep-seated corruption sweeping modern politics. Meanwhile, we look South at Andy (the North) Burnham's patronising stance on Scottish devolution and question how the grassroots independence movement can move forward cleanly with its campaign funds. In this episode, we discuss:Trump, FIFA, and Waffles: We chew over Donald Trump's ridiculous phone call to FIFA to get a player's red card ban delayed—a move that spectacularly backfired as Belgium thumped the US team 4-1 anyway. We dive into the corporate corruption of FIFA rolling into town tax-free, leaving host nations like South Africa lumbered with multi-billion-pound bills.  Farage's Clacton Crisis: Recorded right before his 2 PM showdown, we analyse breaking news regarding Nigel Farage's future in public life. Under intense scrutiny over undeclared security cash, luxury stays, and a mortgage-free £4 million property portfolio, the donations he has received from crypto-billionaires and convicted fraudsters, we ask: is he about to jump before he's pushed by a Standards Commission recall petition?  The King of the North vs. Scottish Self-Determination: We dissect Andy Burnham's predictable words to the Scots, offering regional devolution crumbs while denying Scotland the right to choose its own constitutional future. We contrast this with the media's sudden interest in an Irish border poll, noting how Scotland's constitutional fight is being woundingly ignored by the wider news cycle.  Cleaning Up the Indy Dosh: With questions lingering over old Yes Scotland accounts and the potential return of Peter Murrell's misappropriated SNP money, Fraser and Lesley look at how to build trust. We debate the necessity of setting up an independent fun managed by a well-respected, neutral board to confidently kickstart a fresh independence campaign for 2027. Linkshttps://donation.dec.org.uk/venezuela-earthquake-appeal ★ Support this podcast ★

Quinn from the Failure to Launch (FTL) podcast joins us to discuss exactly how space travel became an adjunct to a racist chatbot. Also, we discuss the high water mark of chudness and what exactly Peter Murrell bought with all his SNP money. Check out Failure to Launch here! Get the whole episode on Patreon here! RILEY ALERT Check out No Gods, No Mayors here! HUSSEIN ALERT Check out 10k Posts here! MILO ALERT Check out Milo's tour dates here: https://www.miloedwards.co.uk/liveshows NATE ALERT Nate's band Second Homes has just released their debut album and you can stream it for free here!

Tanner Hnidey is an economist, freelance speaker, social critic and author. We discuss all things coming up on the SNP year long roadtrip. Cornerstone Forum 26'https://shaunnewmanpodcast.substack.com/Silver Gold Bull Links:Website: https://silvergoldbull.ca/Email: SNP@silvergoldbull.comText Grahame: (587) 441-9100Bow Valley Credit UnionBitcoin: www.bowvalleycu.com/en/personal/investing-wealth/bitcoin-gatewayEmail: welcome@BowValleycu.com Get your voice heard: Text Shaun 587-217-8500

This week we look at the Venezuelan earthquake; Ukraine war;  New York forgets 9/11; Religion and the World Cup; Country of the Week - Austria: Imam mob leader gets police award; Reem Alsalem, UN Raporteur does not believe all women; NSW education department want white men out of science; Pyra Lara Bird-Leakey and the new SNP; The National cancels Kate Forbes;  A new Bach song? ; Skillet's monster no 1 Christian song on Spotify; Eric Clapton - no.2 guitarist; Belgium goes nuclear;  EU Aircon for the bosses but not the workers; Feedback; Bishop of Manchester supports draconian anti-lgbt conversion therapy;  Geoffrey Donaldson;  and the Final Word - Rev 22:12-15  with music from Eric Clapton; Skillet;  Bach;  The Who; Strauss;  The Sound of Music; ACDC;  Johnny Cash.

Joining Iain Dale on Cross Question are Reform UK's Head of Local Government Delivery Ben Bradley, MPs Stella Creasy from Labour and Kirsty Blackman from the SNP, plus The Sun's political correspondent Tom Scotson.

Do you want to see political power passed down from Westminster to your local leaders?Joining Iain Dale on Cross Question are Reform UK's Head of Local Government Delivery Ben Bradley, MPs Stella Creasy from Labour and Kirsty Blackman from the SNP, plus The Sun's political correspondent Tom Scotson.

Joanna Cherry was elected as an MP in 2015, part of the SNP landslide when they took 56 out of 59 Scottish seats, just a year after the referendum on Scottish independence resulted in a No vote. Joanna went on to lose her seat in 2024 and has become a vocal critic of the party, and of Nicola Sturgeon's leadership. She was also well-known for expressing gender-critical views and concerns at a time when the SNP was trying to deliver a gender self-ID law in Scotland. She joins presenter Nuala McGovern to talk about what she describes in her memoir as a "tumultuous decade" in Scottish politics.More than 500 mothers and babies came to harm or died as a result of inadequate care at Nottingham University Hospitals NHS Trust. That's according to Donna Ockenden's review into the maternity services there. Anita Rani speaks to mothers Sarah Hawkins and Sarah Andrews whose babies, Harriet and Wynter, both died from preventable errors.An inclusive fashion show happening in Manchester this weekend is hoping to shine a light on how difficult it can be for people with disabilities, including autism, to find clothes which suit their bodies and feel good. Ellie Brown, the founder of inclusive clothing brand ReCondition, is behind the fashion show and joins Nuala alongside Sam Stein, a YouTuber who makes content about living with autism, who shares how small changes can go a long way.Presenter: Anita Rani Producer: Kirsty McQuire

With peace talks continuing between the US and Iran, what are the big sticking points and what does this all mean for Israel? Following Starmer's resignation, what should we expect next from Downing Street? And after Peter Murrell was sentenced for embezzlement this week, is the SNP finally drawing a line under the affair?Luke is joined by four of The Times' finest journalists to answer your questions on this week's big stories.This podcast was brought to you thanks to the support of readers of The Times and The Sunday Times. Subscribe today: http://thetimes.com/thestoryGuests: Rebecca Myers, foreign editor, The Sunday TimesLizzie Deane, news editor, The TimesDaniel Sanderson, Scottish political editor, The TimesMark Sellman, technology correspondent, The TimesHost: Luke JonesProducers: Harry Bligh, Olivia Case.We want to hear from you - email: thestory@thetimes.comRead more: Marco Rubio kicks off Gulf tour to sell Iran deal to sceptical alliesFurther listening: How infinite scrolling damages our brains Clips: Sky News, Fox News, The Guardian, GB News.Photo: Getty Images. Hosted on Acast. See acast.com/privacy for more information.

Here are the top five insurance products you should be looking to sell during the Medicare lock-in period. The insurance industry never stops moving. Make sure you know the products to keep your business moving along with it.   Read the text version   Get Connected:

Morse code transcription: vvv vvv Peter Murrell to be sentenced for embezzling SNP funds Newspaper headlines Keirs tears... Andys crown and Messiah without a mandate US eases oil sanctions as Iran denies Vance claim on nuclear inspectors Keir Starmer announces resignation as prime minister and Labour Party leader Jeffrey Donaldson Former DUP leader guilty of all child sex abuse charges including one count of rape Man charged with terrorism linked attempted murders in Edinburgh How to get a good nights sleep during hot weather Bedford train crash Police confirm latest hospital figures Two men plead guilty over 39m Transport for London cyber attack Chris Mason Questions multiply for the man tipped to replace Starmer

Searing UK heat leaves schools, hospitals and transport networks struggling to cope, former SNP chief Peter Murrell is sentenced to more than five years for embezzling party funds and we hear what you think should be Burnham's brief if he becomes the next Prime Minister.

Nitric Oxide Explained: Vascular Health, Exercise Performance, and N1o1 with Dr. Nathan Bryan, international Leader in Molecular Medicine, the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He details NO as a ubiquitous messenger affecting blood flow, erectile function, cognition, exercise performance, endothelial dysfunction, and aging-related declines in NO production. Bryan explains why PDE5 inhibitors like Viagra prolong cyclic GMP signaling but don't fix NO deficiency, and why beet products often fail due to variable nitrate content and inadequate dosing. He outlines his NO lozenge approach that generates NO gas from sodium nitrite and magnesium ascorbate, plus a fermented beet powder drink (NOBeets), and emphasizes the role of oral bacteria (and harms of antiseptic mouthwash/fluoride) in nitrate conversion. They review published endpoints, including flow-mediated dilation, blood pressure effects, inflammation markers, triglycerides, stem cells, plaque regression, applications to Alzheimer's, glaucoma/microvascular disease, safety/dosing considerations, risks of arginine supplementation, and a dual-chamber topical NO serum developed from wound-healing experience.

Many schools across England and Wales were partially or fully closed today, with more set to shut tomorrow, as temperatures continue to rise. Also: The former SNP chief executive, Peter Murrell, is jailed for five years for embezzlement. And the Reflecting Pool in Washington is set to be drained as President Trump again blames vandals for its condition.

Maternity care and its shortcomings will be in the spotlight over the next fortnight, as the biggest maternity inquiry in the history of NHS England prepares to report its findings. The independent review by former midwife, Donna Ockenden, has looked into maternity services at Nottingham University Hospitals NHS Trust. Meanwhile new figures from the Royal College of Midwives show that more than nine out of 10 of those polled felt unsafe staffing levels are directly impacting the quality of care they provide for women and babies. Next week we'll also hear the recommendations of a national review by Baroness Amos. BBC's social affairs correspondent, Michael Buchanan, talks to presenter Nuala McGovern about what we know so far. Joanna Cherry was elected as an MP in 2015, part of the SNP landslide when they took 56 out of 59 Scottish seats, just a year after the referendum on Scottish independence resulted in a No vote. Her memoir, Keeping the Dream Alive, captures the disappointment and euphoria of that time. Joanna went on to lose her seat in 2024 and has become a vocal critic of the party, and of Nicola Sturgeon's leadership. She was also well-known for expressing gender-critical views and concerns at a time when the SNP was trying to deliver a gender self-ID law in Scotland. She joins presenter Nuala McGovern to talk about that "tumultuous decade" in Scottish politics.A new study from the Universities of Exeter and Bristol is looking into how heavy periods impact daily life. Led by Gemma Sharp, a Professor of Epidemiology at Exeter, researchers will collect real-time data from thousands of participants to help us understand the relationship between periods - particularly heavy periods - and our energy levels, sleep and mood. Did you know that mini golf has feminist roots? A playful and ‘playable' exhibition, The Art of Mini Golf, has just opened at the Battersea Arts Centre in London, channelling the inclusive, subversive spirit of the game's female founders. Nuala's joined by curator Grace Herbert and one of the featured artists, Delaine Le Bas, to hear more about mini golf's hidden history and the art it's inspired.Presented by: Nuala McGovern Produced by: Sarah Jane Griffiths

This. Is. Superb. The former leader of Scottish Labour gives an impassioned and engrossing analysis of everything happening in Scottish and UK politics: · SNP corruption· Triple by-election reaction· Scottish media pig pen· PLUS! Tartan Army action It's everything you'd want and more. THE POLITICAL PARTY LIVE 9 November: Liz Kendall 21 December: Wes Streeting https://nimaxtheatres.com/shows/the-political-party-with-matt-forde/ SEE the final dates of Matt's stand-up tour 'Defying Calamity' across the UK:https://www.mattforde.com/live-shows June 26 Bristol 1532 - EXTRA DATEJuly 3 Basingstoke The Haymarket - EXTRA DATE 8 Birmingham Glee Club - EXTRA DATE 10 Bedford Quarry Theatre - EXTRA DATE 16 Maidenhead Norden Farm - EXTRA DATE DONATE to the RNOH Charity here:https://www.justgiving.com/campaign/mattforde Hosted on Acast. See acast.com/privacy for more information.

Has Andy Burnham's huge victory against Reform in Makerfield shown the Labour Party how it can beat Farage? What does this defeat mean for the right, and how tricky will the coming months be for Andy Burnham? What does the Tory victory against the SNP in Aberdeen mean for British energy policy? Join Rory and Alastair as they answer all these questions and more. __________ Enjoy Rory and Alastair's interview with James Cleverly by searching ‘Leading' on Spotify, Apple, or YouTube. Go deeper into the world of The Rest Is Politics by signing up for our free newsletter HERE, featuring exclusive interviews, analysis and weekend reads from Alastair and Rory. Join The Rest Is Politics Plus. Start your free trial at therestispolitics.com to unlock exclusive bonus content – including Rory and Alastair's miniseries – plus ad-free listening, early access to episodes and live show tickets, exclusive newsletters, discounted book prices, and a private chatroom on Discord. The Rest Is Politics is powered by Fuse Energy. Stop overpaying for energy. Switch at fuseenergy.com/politics and get a free TRIP+ subscription. Get our exclusive NordVPN deal here ➼ nordvpn.com/restispolitics It's risk-free with Nord's 30 day money back guarantee ✅ __________ Instagram: @restispolitics Twitter: @restispolitics Email: therestispolitics@goalhanger.com __________ Social Producer: Emma Jackson Video Editor: Josh Smith, Kieron Leslie Assistant Producer: Daisy Alston-Horne Producer: Evan Green Exec Producer: Chris Sawyer General Manager: Tom Whiter Learn more about your ad choices. Visit podcastchoices.com/adchoices

King of the North, By-Election Blues, and Tartan Army JoyWell, the by-elections were well worth waiting for. In this delayed "wait for it" by-election special, Lesley and Fraser digest a massive week in UK and Scottish politics. Andy Burnham has secured a predictable but comprehensive landslide in Mackerfield, leaving everyone wondering how quickly he might challenge Keir Starmer for the keys to Number 10. Meanwhile, the SNP faces a disappointing loss in Aberdeen South, prompting questions about energy policy, land taxes, and rural trust. Plus, the Tartan Army takes over America with an incredible display of joy and cultural diplomacy.In this episode, we discuss:Burnham's Path to Number 10: Andy Burnham defeated Reform, Restore, and the Tories combined with 55% of the vote in Mackerfield. We look at his victory speech, the rumors of cabinet resignations, and why Keir Starmer is stubbornly hanging on despite plummeting popularity.Aberdeen South & SNP Frustrations: The SNP lost the Aberdeen South by-election to the Conservatives, the first Tory by-election win in Scotland since 1973. We discuss how Stephen Flynn's move to Holyrood triggered the vote and whether he will take a hit for it. We also dive into the Scottish Government's lack of action on community wealth-building opportunities like onshore wind repowering and land taxes.Tartan Army Takeover: From securing Haggis approvals in Massachusetts to twinning with Glasgow, the Scotland fans are outclassing everyone with their energy and charity work. We contrast their joyful behavior in Boston with the rather more hostile chants coming from England fans in Dallas.Highland Clearances on Film: Lesley shares updates from a poignant filming trip to the clearance site at Rosal in Strathnaver. We discuss the rich oral traditions kept alive by the community, the struggle to find authentic black Highland cows, and how crofters actually lived in longhouses the size of modern three-bedroom bungalows.Upcoming Schedule: There will be no podcast next week as Lesley heads off to an island in Donegal with her bike, panniers, and absolutely no Wi-Fi or potable water. LinksHighland Clearances Interview: Watch the interview with Professor James Hunter on the main Lesley Riddoch YouTube channel.https://youtu.be/U5dCbYELJa8Equitable Energy research about communities taking on repowering contracts -   https://ruralsehub.net/onshore-wind-re-powering-report/ ★ Support this podcast ★

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Nicola Sturgeon has claimed she was deceived by her ex-husband Peter Murrell who pled guilty having embezzled tens of thousands of pounds of SNP money. Financial infidelity has become a top reason behind couples divorces. Alice Wright from The Times joins Michael Simmons to discuss. Hosted on Acast. See acast.com/privacy for more information.

Andy Zaltzman is joined by his panel of political satirists to unpack the critical essays of Tony Blair, the spending habits of Peter Murrell and the SNP, the sweltering heat, social media ban proposals for under 16's and young people in record levels of unemployment.This week's panellists are Scott Bennett, Cody Dahler, Ayesha Hazarika and Bella Hull.Written by Andy Zaltzman.With additional material by: Angela Channel, Sam Nicoresti, Pravanya Pillay and Peter Tellouche. Producer: Rajiv Karia Executive Producer: Pete Strauss Production Coordinator: Asha Osborne-Grinter Sound Editor: Marc WillcoxA BBC Studios Production for Radio 4.

Fast cars, luxury watches – and, of course, that motorhome: the list of what former SNP chief executive Peter Murrell bought with embezzled funds is dizzying. Severin Carrell reports.. Help support our independent journalism at theguardian.com/infocus

As Parliament returns from recess, the latest files related to Peter Mandelson's appointment as UK ambassador to the US are due to be released today. How bad could they be for Labour? Tim Shipman joins James Heale to discuss – has the self-styled 'Prince of Darkness' proven to be more a ghost of Christmas past for the government?Plus: Mandelson isn't the only ghost haunting British politics today. Tim and James discuss the ghost of Christmas present, the scandal facing the SNP. Former party treasurer – and husband to Nicola Sturgeon – Peter Murrell pled guilty to charges of embezzlement, prompting the former First Minister to deliver a teary interview to the BBC at the weekend. How believable did they find Sturgeon? And, with two by-elections on the horizon, what consequences could there be for the SNP?Finally: the boys discuss the latest poll showing Trade Union support ebbing away from Labour towards Reform. So – continuing the Dickensian metaphor (sorry) – could this be Labour's very own ghost of Christmas future?Produced by Megan McElroy and Patrick Gibbons.Become a Spectator subscriber today to access this podcast without adverts. Go to spectator.co.uk/adfree to find out more.For more Spectator podcasts, go to spectator.co.uk/podcasts.Contact us: podcast@spectator.co.uk Hosted on Acast. See acast.com/privacy for more information.

After Laura's exclusive interview, she's joined by Henry and Joe to discuss what Nicola Sturgeon had to say about her estranged husband Peter Murrell's guilty plea to embezzling hundreds of thousands of pounds from the SNP - as well as the political and public reaction to her words.Hear the full length interview on the previous episode of Newscast.You can now listen to Newscast on a smart speaker. If you want to listen, just say "Ask BBC Sounds to play Newscast”. It works on most smart speakers.You can join our Newscast online community here: https://bbc.in/newscastdiscordGet in touch with Newscast by emailing newscast@bbc.co.uk or send us a WhatsApp on +44 0330 123 9480.New episodes are released every day. If you're in the UK, for more News and Current Affairs podcasts from the BBC, listen on BBC Sounds: https://bbc.in/4guXgXdNewscast brings you daily analysis of the latest political news stories from the BBC.The presenter was Laura Kuenssberg and Joe Pike. It was made by Jon Bithrey with Chloe Scannapieco. The social producer was Joe Wilkinson. The technical producer was Jonathan Greer. The assistant editor is Chris Gray. The senior news editor is Sam Bonham.

It's a controversy which has been hanging over the SNP for years - but on Monday former chief executive, Peter Murrell, admitted to embezzling more than £400,000 from the party. On this episode of Newscast, former first minister Nicola Sturgeon sits down with Laura for her first interview since her estranged husband pleaded guilty. Sturgeon, who was earlier arrested and released without charge, discusses what she knew, defends her handling of concerns about party finances, and describes how the revelations have impacted her personally.If you would like to watch the interview, it's also available on BBC iPlayer.You can now listen to Newscast on a smart speaker. If you want to listen, just say "Ask BBC Sounds to play Newscast”. It works on most smart speakers.You can join our Newscast online community here: https://bbc.in/newscastdiscordGet in touch with Newscast by emailing newscast@bbc.co.uk or send us a WhatsApp on +44 0330 123 9480.New episodes released every day. If you're in the UK, for more News and Current Affairs podcasts from the BBC, listen on BBC Sounds: https://bbc.in/4guXgXdNewscast brings you daily analysis of the latest political news stories from the BBC. The presenter was Laura Kuenssberg. It was made by Laurie Kalus and Paul Twinn. The planning producer was Chris Flynn. The technical producer was Jonathan Greer. The assistant editor is Chris Gray. The senior news editor is Sam Bonham.

Peter Murrell, the SNP's former chief executive and Nicola Sturgeon's estranged husband, has admitted embezzling £400,000 in party funds. The guilty plea has revived questions about what senior figures in the SNP knew, how long the scandal had been going on, and what happens next. To discuss the story, including some of the ridiculous purchases including a couple of hairdryers (for a bald man) and £2600 salt and pepper shakers, James Heale and Michael Simmons join Megan McElroy.Become a Spectator subscriber today to access this podcast without adverts. Go to spectator.co.uk/adfree to find out more.For more Spectator podcasts, go to spectator.co.uk/podcasts.Contact us: podcast@spectator.co.uk Hosted on Acast. See acast.com/privacy for more information.

The former SNP chief executive has admitted embezzling more than £400,000 from the party between August 2010 and October 2022, using the money to buy jewellery, cosmetics and a motorhome. Adam Fleming and Alex Forsyth chat it all through with Patrick Maguire from The Times, in front of an audience at Hay Festival. You can now listen to Newscast on a smart speaker. If you want to listen, just say "Ask BBC Sounds to play Newscast”. It works on most smart speakers. You can join our Newscast online community here: https://bbc.in/newscastdiscord Get in touch with Newscast by emailing newscast@bbc.co.uk or send us a WhatsApp on +44 0330 123 9480. New episodes released every day. If you're in the UK, for more News and Current Affairs podcasts from the BBC, listen on BBC Sounds: https://bbc.in/4guXgXd Newscast brings you daily analysis of the latest political news stories from the BBC. The hosts were Adam Fleming and Alex Forsyth. It was made by Anna Harris. The social producer was Jem Westgate. The technical producers were Lewis Allsopp and Darren Wardrobe. The assistant editor is Chris Gray. The senior news editor is Sam Bonham.