Podcasts about Genetics

Dr. Randy Blakely is a Professor of Biomedical Science at Florida Atlantic University and Executive Director of the Florida Atlantic University Brain Institute. Randy is examining how neurons control neurotransmitter signaling, as well as how medicinal drugs and drugs of abuse impact neurotransmitters. He is interested in how normal neurotransmitter regulation and changes in neurotransmission due to drugs ultimately impact behavior. Randy lives in beautiful South Florida near the Everglades, and he likes to spend is free time enjoying nature and observing the local wildlife. While commuting between campuses, Randy listens to a variety of audiobooks, and he is also a big fan of Americana and folk music. He received his B.A. in Philosophy from Emory University and his Ph.D. in Neuroscience from the Johns Hopkins School of Medicine. He next conducted postdoctoral research at the Yale/Howard Hughes Medical Institute Center for Molecular Neuroscience. Randy was an investigator and faculty member at Emory University and Vanderbilt University before accepting his current position at Florida Atlantic University. Randy is the recipient of numerous awards and honors for his research and mentorship. He was awarded the Daniel Efron Award from the American College of Neuropsychopharmacology, two Distinguished Investigator Awards from the Brain and Behavioral Research Foundation, a MERIT Award from the National Institute of Mental Health, a Zenith Award from the Alzheimer's Association, the Delores C. Shockley Partnership Award in recognition of minority trainee mentorship, as well as the Astellas Award in Translational Pharmacology and the Julius Axelrod Award both from the American Society for Pharmacology and Experimental Therapeutics. In addition, he is a Fellow of the American Academy for the Advancement of Science. Randy joins us in this episode to talk more about his life and science.

Welcome to a brand new year on the Beautifully Broken Podcast. In this solo episode, I'm reflecting on what mattered most in 2025 and what I'm bringing into 2026 with intention and clarity. I talk about the frustrations I've felt with the wellness world's obsession with quick-fix marketing, and how that led me back to the basics: digestion, cellular health, nervous system regulation, and real human connection.You'll hear the most impactful changes I made, like dialing back my supplements, leaning into bioavailable fats, ditching Amazon for Fullscript, and embracing "the year of the gases" with nanobubbled oxygen and Brown's gas. I share how I built a community around healing, hosted my first wellness event, and finally brought the Biological Blueprint Academy to life. This is a behind-the-scenes look at the principles that grounded me and the practices that restored me. And yes, it's all rooted in love, curiosity, and cellular integrity.  Episode Highlights[00:00] – Kicking off 2026 and calling out the marketing noise in the wellness world[02:00] – Simplifying supplements: how lab work shaped a leaner, smarter stack[03:50] – Fullscript vs Amazon: why sourcing and quality control matter[05:30] – Mago7, digestion, and the real-life wins that come from getting “regular”[06:45] – The year of gases: hydrogen, Brown's gas, oxygen baths, and what really helped my sleep[10:12] – Building therapies into daily life without stealing time[12:35] – CO₂ tolerance and breathing into cognitive clarity[14:00] – Beam Minerals and foundational mineral support[15:25] – Living the work: grounding, breathwork, cold exposure, red light, and temperature as medicine[17:51] – Genetics, mold sensitivity, and why foundational awareness is so powerful[20:14] – South Austin Wellness Project: hosting my first healing community event[22:36] – Access, advocacy, and why sharing healing tools is a mission, not a market[24:55] – New website, Substack migration, and podcast episode mini-pages[26:00] – A manifesto for 2026: depth over drip, principles over protocols[27:11] – The podcast as discovery: why this journey means everything to me Links & ResourcesSilver Biotics: bit.ly/3JnxyDD— 30% off with Code: BEAUTIFULLYBROKENCathcBio https://www.catchbio.com/beautifullybroken— Code: beautifullybrokenStemRegn: https://www.stemregen.co/products/release?_ef_transaction_id=&affid=52&oid=1Beam Minerals: http://beamminerals.com/beautifullybroken— Code: BEAUTIFULLYBROKEN CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/beautifullybroken.world/) YouTube: https://www.youtube.com/@freddiekimmel Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This episode covers Fragile X syndrome.Written notes can be found at https://zerotofinals.com/paediatrics/genetics/fragilex/Questions can be found at https://members.zerotofinals.com/Books can be found at https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

Send us a textWhat if cancer didn't have to be eradicated, but could be remembered, monitored, and controlled by the immune system itself?In this episode of Causes or Cures, Dr. Eeks speaks with Dr. Zachary Hartman, the lead researcher who revisited an extraordinary breast cancer vaccine trial conducted over 20 years ago. The trial involved a small group of women with advanced breast cancer. Women who, remarkably, are all still alive today.By analyzing their blood decades later, the research team discovered that these women still carried immune cells capable of recognizing their cancer, suggesting durable immune memory lasting more than two decades. (Study link here.)We discuss:The original breast cancer vaccine trial and what it was designed to do, in plain languageWhat it was like to discover that the women from the trial was still alive more than 20 years laterHow the immune systems of these women continued to recognize cancer cells long after the trialWhat CD27-positive immune cells are and why they matter, explained simplyWhy helper CD4 T cells may be just as important, or more important, than killer CD8 T cells when it comes to cancerWhat happened when researchers combined a CD27-boosting antibody with a cancer vaccine in miceWhat surprised the research team mostThe challenges of translating findings from mice to human trialsWhether cancer could someday be managed long-term by the immune systemHow generalizable this immune memory might be across different cancersWhat this research could mean for how we think about vaccines in a post-pandemic worldThe one key message the researcher hopes the public takes awayWhat's next in this line of researchThis episode offers a rare, hopeful (but scientifically grounded) look at how the immune system may be capable of remembering cancer for decades. Guest Bio: Dr. Zachary C. Hartman is an Associate Professor at Duke University in the Departments of Surgery, Pathology, and Integrative Immunobiology, where he also serves as Director of the Center for Applied Therapeutics and is a member of the Cellular and Molecular Biology and Genetics and Genomics programs. He earned his undergraduate degree from Northwestern University and completed his PhD at Duke University, followed by postdoctoral training in tumor immunology and breast oncology at Duke and the MD Anderson Cancer Center. In 2012, Dr. Hartman returned to Duke to establish a research program focused on tumor immunology and the development of cancer immunotherapies, including therapeutic vaccines, immune agonists, checkpoint inhibitors, antibody-based therapies, and strategies to stimulate anti-tumor immune responses.  Work with me? Perhaps we are a good match. You can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Follow Public Health is WeirdOr Facebook here.Or X.OnSupport the show

On today's episode: How to increase your chances of succeeding at this year's resolution. And we talk about procrastination… or… I dunno… maybe we'll do something else… All that and more today on All Around Science...RESOURCESFraming New Year's Resolutions: Lessons From Science And LeadershipA large-scale experiment on New Year's resolutions: Approach-oriented goals are more successful than avoidance-oriented goals | PLOS OneWhy procrastination isn't laziness – it's rigid thinking that your brain can unlearn | The ConversationDigital Media, Genetics and Risk for ADHD Symptoms in Children – A Longitudinal Study | AAPProcrastination and the Priority of Short-Term Mood Regulation: Consequences for Future SelfCREDITS:Writing - Bobby Frankenberger & Maura ArmstrongBooking - September McCrady THEME MUSIC by Andrew Allenhttps://twitter.com/KEYSwithSOULhttp://andrewallenmusic.com Hosted on Acast. See acast.com/privacy for more information.

Nspecta of CSI Humboldt, Bodhi of Bodhi Seeds, & Shabud of 707 Seedbank join Matthew Riot of Riot Seeds to Present, Review and Discuss "The Cannabible" by Jason King, Book 3 (the yellow one).  This single book is split into 3 parts.Educational, historical, & public interest used with permission by the author.Youtube is currently on an Anti-Cannabis History content campaign and its made it very hard to show the video versions of these books, however they will be available on ONE of our 3 Syndicate channels we have created to stop this ignorance.

* On the 150th Anniversary of the Proclamation, the Surprising Truth: With yesterday (January 1st, 2023) being the 160th anniversary of the Emancipation Proclamation, we are going back to a broadcast classic where Bob Enyart and guest Jamie Schofield analyze the meaning and actual intent of that sad document. For this was no abolitionist policy (as a contemporaneous report in the Rocky Mountain News makes clear), but an example of moral compromise that ended in failure. Today's Resource: The Plot | Second Edition!The Bible Gets Easier to Understand: Apparent contradictions plague many Bible students. The Plot demonstrates how hundreds of such contradictions disappear when the reader applies the big picture of the Bible to its details. Tunnel vision focuses so narrowly on a problem that the solution often lies just out of view. As the pastor of Denver Bible Church, Bob Enyart teaches Christians how to use the whole counsel of God to understand the plot of the Bible and solve biblical mysteries. (Missionaries in Costa Rica effectively use the Spanish translation, La Trama.) Available as either book or PDF download. The Plot: 2nd Edition Just before his passing, Bob finished the second edition of his manuscript, The Plot. While sadly he didn't live long enough to see the work published, He did get it out just in time. His second edition includes ten years worth of updates, revisions, additional sections and updated graphics. Now, a year after his passing, it has been made available to the public! Get your copy now... The Proclamation was actually comprised of two announcements, not just one.  The first half – the preliminary proclamation – set the policy and gave a deadline of 100 days.  It was addressed not to the common citizens of the nation or to the Union military, but rather to the states in rebellion at that time.  What was Lincoln's declared policy on slavery at that time?  He made that very clear in a letter to Horace Greeley on Aug. 22, 1862, just days before the issuance of the preliminary proclamation: If there be those who would not save the Union, unless they could at the same time save slavery, I do not agree with them. If there be those who would not save the Union unless they could at the same time destroy slavery, I do not agree with them. My paramount object in this struggle is to save the Union, and is not either to save or to destroy slavery. If I could save the Union without freeing any slave I would do it, and if I could save it by freeing all the slaves I would do it; and if I could save it by freeing some and leaving others alone I would also do that. What I do about slavery and the colored race, I do because I believe it helps to save the Union; and what I forbear, I forbear because I do not believe it would help to save the Union. . . . I have here stated my purpose according to my view of official duty; and I intend no modification of my oft-expressed personal wish that all men everywhere could be free. Lincoln's goal was not the abolition of slavery but rather the preservation of the Union, and if that meant keeping slaves in bondage everywhere, he would support and practice exactly that.  And this non-abolitionist stance is reflected in the text of the Emancipation Proclamation.The Preliminary Proclamation, September, 1862 In short, the stated intent and purpose of this policy was to offer the Confederate states the opportunity to keep their slaves if they would choose to stop rebelling within a 100-day deadline.  Essentially, it said that if your state ceases its rebellion against the union, you may keep your slaves. I, Abraham Lincoln, President of the United States of America, and Commander-in-Chief of the Army and Navy thereof, do hereby proclaim and declare that hereafter, as heretofore, the war will be prosecuted for the object of practically restoring the constitutional relation between the United States... That on the first day of January in the year of our Lord, one thousand eight hundred and sixty-three, all persons held as slaves within any State, or designated part of a State, the people whereof shall then be in rebellion against the United States shall be then, thenceforward, and forever free; Any state still in rebellion against the Union on Jan. 1 would be subject to the Proclamation, which would declare any current slaves in those areas to be free.  The stated goal was not to free any slaves, but rather to preserve the Union.  Was it a success?  Before hearing the answer, Bob predicted that such a policy would bear no fruit, and he was right.  In fact, not a single state took Lincoln up on his offer.  By its own standard, the Proclamation was an abject failure!  In fact, all the proclamation did in that regard was to infuriate the Confederate states more than ever, deepening their resolve to reject the Union. Perhaps even worse, the preliminary proclamation also explicitly ordered slaves to be returned to their slave owners in specific circumstances, thus actually ordering the enforcement of keeping such men in bondage: Sec.10. And be it further enacted, That no slave escaping into any State, Territory, or the District of Columbia, from any other State, shall be delivered up, or in any way impeded or hindered of his liberty, except for crime, or some offence against the laws, unless the person claiming said fugitive shall first make oath that the person to whom the labor or service of such fugitive is alleged to be due is his lawful owner, and has not borne arms against the United States in the present rebellion, nor in any way given aid and comfort thereto; In other words, if a slave escaped to an area controlled by the Union, all a Southern slave owner had to do was show up, give an oath (no evidence required) that he was the lawful owner of that slave, and swear that he had never taken up arms against the Union, and then “here's your slave back.” The Emancipation Proclamation, January 1, 1863 This document was the culmination of the policy already given 100 days earlier.  Not a single Confederate state had taken Lincoln's offer to cease rebellion and keep their slaves.  Therefore, this document declared (largely symbolically) the slaves in those non-Union-controlled areas to be free.  But, at the same time, and as one should expect in such a compromised and non-abolitionist policy, it also explicitly listed all of the areas in the U.S. where slaves would be kept in bondage.  Thus, this policy actually authorized the continuing wicked enslavement of innocent men, women and children, for example in many counties in Louisiana, especially around New Orleans, as well as in the newly-forming West Virginia. Many abolitionists of the day decried the Emancipation Proclamation, rightly pointing out its moral compromise.  Lincoln's own secretary of state, William Seward, commented that "We show our sympathy with slavery by emancipating slaves where we cannot reach them and holding them in bondage where we can set them free."  Unlike Lincoln, Seward knew the atrocities of slavery firsthand, having been raised by a slave-owning family.  "I early came to the conclusion that something was wrong... and [that] determined me to be an abolitionist." On the other hand, in their coverage of the Proclamation, the now-defunct Rocky Mountain News here in Colorado celebrated on their front page the fact that this policy was not abolitionist, and mocked abolitionists who disagreed with it, praising Lincoln for going against the “radical” abolitionists.  The newspaper wrote: “The last mail... brought scores of Eastern and Western papers with similar recommendations.  The voice of the press is almost unanimous in its approval.  That is a pretty correct index of popular opinion, and we may therefore set down that almost the entire loyal States endorse the action of the President.  It must be expected that the ultra Abolitionists will kick against it, as too conservative [not going far enough] for their radical views.  Let them squirm!  ‘Honest Abe' has shown that he will be no tool of theirs.” How were slaves freed and slavery abolished, then? It's important to note that the Emancipation Proclamation didn't outlaw slavery anywhere.  It declared current slaves in those areas to be free, in areas where the Union had no control.  It essentially “freed” them in word only, and was largely a symbolic gesture.  As the Union military moved through the Confederate states in rebellion, they did free slaves they encountered.  In truth, they could have done this with or without the Proclamation.  The Proclamation was simply used as an excuse to do it, but they would have been right to do it, regardless.  Lincoln gave orders to the Union Army to free those slaves, apart from the Proclamation, which wasn't addressed to the Union Army, but to the Confederate States themselves.  He could have ordered the Union Army to do this without such a proclamation.  And even if Lincoln hadn't issued that order, it would have still been right for Union forces moving through the South to free those slaves, anyway.  If you are a military unit and have taken over an area from the enemy, and you find men who have been kidnapped and brutalized by the people there, the right thing to do would be to free those victims.  The Proclamation didn't free anyone, although it did serve as a political excuse to do so. What of the abolition of slavery, then?  That was accomplished later, in some areas at the state level, and in the rest of the nation through federal action.  Unlike in the Emancipation Proclamation, in all of these cases it was a principled, no-compromise, abolitionist policy that required the complete abolition of slavery in each state.  For example, West Virginia (which had ironically seceded from Virginia while the latter was seceding from the Union) wasn't allowed to join the Union as a new state unless their constitution abolished slavery without exception.  In Maryland, Arkansas and Louisiana in 1864, they abolished slavery at the state level as their citizens ratified new state constitutions.  In Missouri in January of 1865, that governor abolished slavery via executive order.  In all other Southern states, slavery was ultimately abolished through the ratification of the 13th amendment to the U.S. Constitution, in December of 1865. In all of these cases, it was a no-compromise policy that we would describe today as “pro-personhood.”  Slavery was ultimately abolished despite the pro-slavery policy of the Emancipation Proclamation, not because of it.

This episode covers Marfan syndrome.Written notes can be found at https://zerotofinals.com/paediatrics/genetics/marfan/Questions can be found at https://members.zerotofinals.com/Books can be found at https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

01. 1991, Mugatu, Mali - Koa - Love Is The Answer 02. Armin Van Buuren, Pendulum & Rob Swire - Sound of You 03. Yasuki - Strong Enough 04. John B - Das Boot 05. Levela - LOST 06. Andromedik, Lauren L'aimant - Air 07. Idle Days - Who Am I 08. Karen Harding, Dimension - Guardian Angel 09. El Pablo Feat. Kaye - Party 10. Culture Shock, Sarah De Warren - All The Things She Said (Culture Shock Version) 11. Kleu - Bam 12. T - Trider - To The Limit 13. Artino - Wanna Feel It 14. Andy C, Axwell, Max'c - Believe Again (I Found U) 15. Muzz - Enigma 16. Apokain - Energy 19 17. Streetflicker, Riddo - ALALA 18. Grafix & Madishu - We're On Fire 19. Apres La Classe - Paris (Dj Ferro Remix) 20. Average Citizens - Drive By Bassline (Woofax DNB Remix) 21. Metrik - Synchronise 22. Charlotte Devaney, Ayah Marar - LAST NIGHT (Drumsound & Bassline Smith Remix) 23. T & Sugah - Louder 24. Circadian & Mozey - LOUDER 25. Delta Heavy - Substance 26. Dimension; DJ Aligator - Blow My Whistle 27. Crissy Criss - DANCE 28. Apokain - Forward 29. Drumsound & Bassline Smith - Aim High 30. Dirtyphonics & Ivory - On Lock 31. Dub Elements - Dirty Vibes 32. Kanine - Feel The Vibration 33. Matrix & Futurebound, Miss Trouble - Motivation 34. Tengu - Take Me There 35. Dr. Apollo & Jordan Grace - Take Me Away 36. Bugwell - Palace 37. Feed The Fire - Bad Boy Sound 38. Dr. Apollo - Pull Up To The Club 39. Rockman - Elevate 40. React - Revamp 41. Sub Focus, Fireboy Dml, Irah - Original Don 42. Shockone, Nct, Scrufizzer - Rockstar Bass 43. Ryan Audley, Nuwei - Bass Is Pumping 2.0 44. Lexed; Melic - Burn It Up 45. Genetics, Method - Eat Sleep Rave Repeat 46. Dub Elements - Hot & Heavy 47. Eskei83, Born Global, Bomsh - More Fire 48. Tantrum Desire - Don't Look Back 49. Tantrum Desire - Concentrate 50. Loboski, Krasia - Defcon 1 51. Dux N Bass - Dreams 52. T & Sugah, Control Alt Delete, Kris Kiss - The Formula 53. Dubra - Boombox 54. Eskei83, René Lavice And Ucee - Bad To Di Bone 55. Manta - Into The Night 56. Artino, Sem - Misfits 57. Sub Focus, Fireboy Dml - Ecuador 58. Saint Rider - Habibi 59. Subsonic - Hit The Brakes 60. Mage - Love Better, Kiss Faster 61. Sless - Astrogirl 62. Sub Focus, Bbyclose - On & On (Kanine Remix) 63. Delerium, Sarah Mclachlan, John Summit - Silence (Dimension Remix) 64. Icons - Paradise 65. Grafix, Raphaella - Memories (Us Together) 66. Junk Mail - Best Genre In The World 67. Project Zeus - Put Em Up 68. Tc - Tap Ho (ZOMBIE CATS & NEMEAN Rework) 69. Project Zeus, Dropset - Right Now 70. Subtronics & Friction Feat. P Money - Legends 71. A.m.c, Suune, Phantom - Gas 72. René Lavice & Inja - Go Nuts 73. Liquid Stranger, Sully & Sukuward - Dynamite 74. Midnight Cvlt, Litence - Numba One 75. Madface - Mugeni 76. Mandidextrous, Matt Scratch - Fred Spookie 77. T & Sugah - Don t Stop 78. Skepsis & Doktor - Arctic 79. Feed The Fire - FIRE 80. Green Vibes - Attention 81. Serial Killaz, Mad Sam - Toppa Top 82. Lmnop, Berto Antonio - Moves Like Fire 83. Conni X Niall T - Bella Ciao 84. Teebee - The Way (> Greater Than Remix)

Five sci-fi technologies becoming real today, from BCIs to space elevators.Get Nebula using my link for 50% off an annual subscription: https://go.nebula.tv/isaacarthurCheck out Joe Scott's Oldest & Newest: https://nebula.tv/videos/joescott-oldest-and-newest-places-on-earthWatch my exclusive video Chronoengineering: https://nebula.tv/videos/isaacarthur-chronoengineering-manipulating-time-as-technologyGrab one of our new SFIA mugs and make your morning coffee a little more futuristic — available now on our Fourthwall store! https://isaac-arthur-shop.fourthwall.com/Visit our Website: http://www.isaacarthur.netJoin Nebula: https://go.nebula.tv/isaacarthurSupport us on Patreon: https://www.patreon.com/IsaacArthurSupport us on Subscribestar: https://www.subscribestar.com/isaac-arthurFacebook Group: https://www.facebook.com/groups/1583992725237264/Reddit: https://www.reddit.com/r/IsaacArthur/Twitter: https://twitter.com/Isaac_A_Arthur on Twitter and RT our future content.SFIA Discord Server: https://discord.gg/53GAShECredits:5 Sci-Fi Fantasies That Could Soon Become RealityWritten, Produced & Narrated by: Isaac ArthurEditor: Donagh BroderickSelect imagery/video supplied by Getty ImagesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

About 24.2% of U.S. men today screen positive for erectile dysfunction (ED), while global rates range from 3% to 76.5%, showing it's a common health problem that affects men of all ages A 2025 study in the American Journal of Clinical and Experimental Urology found that ED is influenced by genes that also raise risk for obesity, diabetes, heart disease, and addiction, tying erection problems to long-term heart health ED is usually multifactorial, with vascular, neurogenic, hormonal, and psychogenic forms, and is strongly associated with conditions like heart disease, obesity, sleep apnea, and depression, making it a powerful early warning sign that something deeper is wrong While drugs like Viagra can temporarily improve erections, they don't work for everyone and may be unsafe for men taking heart and lung medications Instead of relying solely on pills, addressing root causes with a heart-focused check-up, a metabolic-friendly diet, pelvic floor training, restorative sleep, enough sunlight and mindful supplementation can help restore sexual function without more drugs

Shunji Tomatsu, MD, PhD, Professor and Head, Nemours Children's Health, Delaware, USA; Alessandra d'Azzo, PhD, Emerita Faculty, Genetics, St. Jude Children's Research Hospital, Tennessee, USA; Merve Emecen Sanli, MD, Associate Professor, Department of Pediatrics, University of Texas Southwestern Medical Center, Texas, USA; and Ryan Colburn, patient with Pompe disease and president of Odimm Inc, discuss new and emerging gene therapies for lysosomal disorders.This continuing education activity is provided through collaboration between the Lysosomal and Rare Disorders Research and Treatment Center (LDRTC), CheckRare CE, and AffinityCE. This activity provides continuing education credit for physicians, physician assistants, nurses, nurse practitioners, and genetic counselors. A statement of participation is available to other attendees.To obtain CME/CE credit, please visit https://checkrare.com/learning/p-grids2025-session6-current-issues-in-gene-therapies-for-lysosomal-disorders/  Learning ObjectivesDescribe current and emerging gene therapy data in lysosomal disorders and its clinical relevanceDescribe role of patients in gene therapy developmentFacultyShunji Tomatsu, MD, PhD, Professor and Head, Nemours Children's HealthAlessandra d'Azzo, PhD, Emerita Faculty, Genetics, St. Jude Children's Research HospitalMerve Emecen Sanli, MD, Associate Professor, Department of Pediatrics, University of Texas Southwestern Medical CenterRyan Colburn. Odimm, Inc.DisclosuresAffinityCE staff, LDRTC staff, planners, and reviewers, have no relevant financial relationships with ineligible companies to disclose. Faculty disclosures, listed below, will also be disclosed at the beginning of the Program.Shunji Tomatsu, MD, PhD Dr. Tomatsu has received the following grants: Morquio Foundations and families: Scarlett Grifith, Bennett, A Cure for Roberts, and Morquio Conference; MPS Societies: Japanese, National, and Austrian; NIH grants: 1-R01-HD102545, NIH, NICHD, Tomatsu (PI), 1R01HD104814-01A1, NIH, NICHD, Langan, T.J. (PI), Role: Site-PI, R43HD114328-01, NIH, ACOSTA, WALTER (PI), Role: site PI, 1R43AR084638-01, NIH, MOUNZIH, KHALID (PI); Foundation of NIH: FNIH RFP NUMBER: 2022-BGTC-005 Tomatsu (PI). Alessandra d'Azzo, PhDDr. D'Azzo has no relevant financial relationships to disclose.Merve Emecen Sanli, MDDr. Sanli has no relevant financial relationships to disclose.Ryan ColburnMr. Colburn has an advisory, consulting and/or project based relationship or stock holding with: Abeona Therapeutics, Amicus Therapeutics, Astellas Gene Therapies, Avidity Biosciences, Bayer, Catalyst Pharmaceuticals, Denali Therapeutics, M6P Therapeutics, Sangamo Therapeutics, Sanofi, Solid Biosciences.Mitigation of Relevant Financial RelationshipsAffinityCE adheres to the ACCME's Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CME activity, including faculty, planners, reviewers, or others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity. Conflicts of interest for presenting faculty with relevant financial interests were resolved through peer review of content by a non-conflicted reviewer.Accreditation and Credit DesignationPhysiciansThis activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of AffinityCE and the LDRTC. AffinityCE is accredited by the ACCME to provide continuing medical education for physicians.AffinityCE designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.Physician AssistantsAffinityCE designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credits™. Physician Assistants should claim only the credit commensurate with the extent of their participation in the activity.NursesAffinityCE is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation (ANCC). This activity provides a maximum of 1 hours of continuing nursing education credit.Nurse PractitionersAffinityCE designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credits™. Nurse practitioners should claim only the credit commensurate with the extent of their participation in the activity.Genetic CounselorsAffinityCE designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credits™. Genetic Counselors should claim only the credit commensurate with the extent of their participation in the activity.Other ProfessionalsAll other health care professionals completing this continuing education activity will be issued a statement of participation indicating the number of hours of continuing education credit. This may be used for professional education CE credit. Please consult your accrediting organization or licensing board for their acceptance of this CE activity. Participation CostsThere is no cost to participate in this activity.CME InquiriesFor all CME policy-related inquiries, please contact us at ce@affinityced.comSend customer support requests to cds_support+ldrtc@affinityced.com

Hosts Kevin Palmieri and Alan Lazaros challenge the belief that setting bigger goals automatically builds confidence. They explain why self-belief is earned through alignment, proof, and disciplined action, not motivation or hype. Drawing from psychology and thousands of real coaching conversations, they show how misaligned goals quietly erode confidence and consistency over time. This episode reframes what real self-belief looks like and how it is built one credible win at a time.If you want stronger follow-through, clearer goals, and confidence you can trust, listen closely. Build belief the hard way so it actually lasts.Learn more about:Next Level University Monthly Masterclass, "How to Set and Achieve Your Most Important Goals in 2026." One hour. Real principles. Lasting breakthroughs:https://us06web.zoom.us/meeting/register/-ShY-iGKTEKPlsx3oCJUWw#/registrationIf you want to start, grow, scale, or monetize your podcast? Join our “Next Level Podcast Accelerator” – Round 21 – Starting January 6, 2026. Use promocode: NLULISTENER, for 30% off - https://www.nextleveluniverse.com/group-coaching/_______________________NLU is not just a podcast; it's a gateway to a wealth of resources designed to help you achieve your goals and dreams. From our Next Level Dreamliner to our Group Coaching, we offer a variety of tools and communities to support your personal development journey.For more information, check out our website and socials using the links below.

Stayin' Alive shows up with a name that sounds like it should be a whole soundtrack, and the vibe honestly matches, just not in the way people expect. This is Pure Plan's rosin badder, cold-cure style, and the genetic line is Disco Fries x Amnesia OG, which explains a lot about why it feels upbeat, chatty, and mentally switched on.  The first thing you notice is the flavor, because this one does not whisper. You called it guava with that fermented fruit twist, almost kombucha-adjacent, and that is dead on for how “funky-tropical” rosin can hit when it's done right.  It's not “gas” in the classic punch-you-in-the-face way, it's more like fruit got interesting and decided to become a personality.Then the effects come in clean and bright. Not super heady, not couch-glue, more “eyes open, brain curious.” You even clocked that little pressure in the cheeks and forehead, like your face is gently confirming we are, in fact, high right now.  The mood lane is calm, happy, relaxed, and slightly energetic, the kind of high where you suddenly want to be in community. This is the “phones in the basket” strain, the one that makes a living room feel like a hang again.  The one downside, especially at Beehive pricing, is the runtime. You were feeling 20 to 30 minutes and already thinking about another dab, which makes this feel a little too snackable for concentrate money.  Also worth saying out loud, if you overdo it, you said it can flirt with anxiety, but it passed quick. So, small dabs first, let it land, then decide if you want to climb.  For body relief, this wasn't your hero. You didn't rate it as a pain play, and it read more like social, creative, curious energy than deep physical melt.  If your goal is heavy relief, this is probably not the first jar you reach for. If your goal is to vibe, talk, laugh, watch something weird, or fall into a documentary rabbit hole like you're doing research for a PhD in Ancient Aliens, Stayin' Alive understands the assignment.  Genetics, Disco Fries x Amnesia OG.  THC about 78%, with CBG about 1.64%, treat as batch-specific to your jar.  Top terpenes , beta-caryophyllene 2.12%, myrcene 1.329%, limonene 1.019%, humulene 0.989%, linalool 0.367%.  Save on Dr Dabber with Code: Cannabisschool10Save on Storz & Bickel with Code : CannabisschoolSave on Santa Cruz Shredder with Code: CSP10Save on Bomb Erigs with Code: CSPScore 100 on your test

Show notes: (0:00) Intro (0:41) Who is Dr. Michael Snyder, and what does he do? (3:44) Catching type 2 diabetes early through personal health tracking (5:59) Why knowing your health baseline matters more than one-time scans (8:49) Using smartwatches to detect illness before symptoms (12:02) Tracking health on a budget (17:04) Why glucose monitors may be the most powerful health tool (18:26) Diabetes subtypes and why one diet does not work for everyone (20:57) Figuring out your diabetic type (24:57) Diet and foods for diabetes (31:55) GLP-1 drugs, benefits, risks, and who they help most (40:26) Genetics vs. epigenetics (44:41) Current studies (46:00) DNA sequence and DNA methylation (48:27) Outro   Who is Dr. Michael Snyder?  Michael Snyder, PhD, is a professor at Stanford University School of Medicine, former chair of Genetics, and director of the Stanford Center for Genomics and Personalized Medicine. He is a leader in genomics and personalized health, known for using DNA, blood data, imaging, and wearable devices to track health early and prevent disease. His research focuses on studying people while they are healthy to catch problems before symptoms appear. Dr. Snyder has published hundreds of scientific papers, launched multiple health tech companies, and authored Genomics and Personalized Medicine: What Everyone Needs to Know. His goal is to shift medicine from sick care to true health care.   Connect with Dr. Snyder Website: https://med.stanford.edu/content/sm/snyderlab.html/ Links and Resources: Peak Performance Life - https://buypeakperformance.com/ Peak Performance on Facebook - https://www.facebook.com/livepeakperformance/ Peak Performance on Instagram - https://www.instagram.com/livepeakperformance

This episode covers Noonan syndrome.Written notes can be found at https://zerotofinals.com/paediatrics/genetics/noonansyndrome/Questions can be found at https://members.zerotofinals.com/Books can be found at https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor talk with pediatric eating disorder specialist Dr. Julie O'Toole (Kartini Clinic) and pediatric obesity expert Dr. Evan Nadler about what childhood obesity really is: a biologic, metabolic disease—not a willpower problem and not a failure of parenting.They explore how excess weight, constant hunger, and disordered eating in kids are often signs of underlying metabolic dysfunction and genetics—and why the old “eat less, move more” advice can do real harm, especially when children are shamed or restricted in the name of “health.”Key Questions AnsweredWhy is childhood obesity a metabolic disease, not a behavior problem?How are obesity and eating disorders deeply connected instead of opposite extremes?What role do GLP-1 medications play in children—and how do we protect against under-fueling?When should parents suspect genetic drivers like hyperphagia or MC4 mutations?How can medical treatment for obesity actually reduce disordered eating behaviors?When does excess weight become a medical issue requiring metabolic evaluation—not another diet?Key TakeawaysWeight is a symptom. Childhood obesity is often a sign of metabolic dysfunction, not overeating.Obesity & eating disorders overlap. Restriction can trigger disordered eating; disordered eating can worsen obesity.“Eat less, move more” harms. Shame-based approaches delay treatment and increase risk of eating disorders.GLP-1s work metabolically, not just through appetite suppression. Kids still need consistent fueling.Genetics matter. Single-gene differences can drive severe childhood hunger & rapid weight gain.Not treating is harm. Avoiding obesity care violates first, do no harm.Dr. Cooper's Actionable TipsIf your child is gaining weight or constantly hungry, request metabolic labs (insulin, glucose, lipids, liver, hormones).If the doctor only says “eat less, move more,” ask: “How are we evaluating metabolism and genetics?”On GLP-1s? Monitor for under-fueling (skipped meals, low energy, food anxiety) and intervene promptly.Notable Quote“Not treating childhood obesity is doing harm. It's a disease, not a lifestyle choice.” — Dr. Evan NadlerLinks & ResourcesPodcast Home: Fat Science WebsiteEpisodes & Show Archive: Cooper Center Podcast PageEducation & Metabolic Resources: coopermetabolic.com/resourcesSubmit a Show Question: questions@fatsciencepodcast.comEmail Dr. Cooper Directly: dr.c@fatsciencepodcast.comConnect with Our GuestsDr. Evan P. Nadler, MD, MBA – Founder, ProCare Consultants & ProCare TeleHealthWebsite: obesityexplained.comYouTube Channel: Obesity ExplainedDr. Julie K. O'Toole, M.D., M.P.H. – Chief Medical Officer & Founder, Kartini ClinicWebsite: kartiniclinic.comBooks: amazon.com/author/julieotoole*Fat Science breaks diet myths and advances the science of real metabolic health. No diets. No agendas. Just science that makes you feel better. This episode is informational only and not medical advice.

Stephen and Harry Serpanos delve into various aspects of nutrition, genetics, and health. They discuss the misconceptions surrounding dietary supplements, the role of dairy in diets, and the importance of understanding individual genetic adaptations. The conversation also touches on leaky gut syndrome, the benefits of fermented foods, and the significance of animal fats in nutrition. They explore the one meal a day approach and the potential effects of psilocybin on health. Throughout the discussion, they emphasize the need for critical thinking and personalized approaches to diet and health.Harry's YouTube channel https://www.youtube.com/@HarrySerpanosChapters00:00 Introduction to Harry Sopandos and His Insights03:01 The Complexity of Nutrition and Personal Experiences06:06 Environmental Factors Affecting Health08:57 Debunking Myths Around Dairy Consumption11:54 Understanding Leaky Gut and Its Implications14:57 The Role of Fermented Foods in Diet18:04 The Science Behind Dairy and Gut Health21:01 Exploring Pastoral Genes and Calcium Absorption36:37 The Impact of Diet on Health39:04 Genetics and Nutritional Adaptations43:15 The Importance of Protein in Healing53:15 One Meal a Day: A Sustainable Approach?59:55 Genetics and Health: The Twin Study Insight01:06:14 Understanding Omega-6 and Animal Fats

Radio Baloney Live! Woke Journo Vs Genetics, Aussie Censorship, Trump Christmas Post,UK Police StateBecome a supporter of this podcast: https://www.spreaker.com/podcast/radio-baloney-the-richie-baloney-show--4036781/support.

What if the key to aging well isn't found in general advice—but in your genes?In this episode of The Aging Well Podcast, Dr. Jeff Armstrong sits down with Dr. Kendal Stewart, a renowned neurotologist and genomic medicine expert, to discuss how genetics, neuroplasticity, and targeted nutrition are reshaping how we understand health, longevity, and cognitive performance.With more than 40 years of experience—from skull base surgery to cutting-edge functional medicine—Dr. Stewart has helped thousands of patients worldwide navigate complex neurological and immune challenges. Together, Jeff and Dr. Stewart unpack how individualized genetic insights can guide smarter lifestyle, nutritional, and wellness strategies that promote vitality and brain health as we age.If you've ever wondered how your genes influence how you age—and what you can actually do about it—this conversation will change the way you think about your body, your brain, and your potential to thrive across the lifespan.Learn more about Dr. Stewart at https://www.drkendalstewart.com/Please, support The Aging Well Podcast by hitting the ‘like' button, subscribing/following the podcast, sharing with a friend, and….BUY the products you need to… age well from our trusted affiliates and support the mission of The Aging Well Podcast*.The Aging Well Podcast merchandise | Show how you are aging well | Use the promo code AGING WELL for free shipping on orders over $75 | https://theagingwellpodcast-shop.fourthwall.com/promo/AGINGWELLAuro Wellness | Glutaryl—Antioxidant spray that delivers high doses of glutathione (“Master Antioxidant”) and the all new Copper Tripeptide (GHK-Cu) | 10% off Code: AGINGWELL at https://aurowellness.com/agingwellpodcastBerkeley Life | Optimize nitric oxide levels | Purchase your starter kit at a 15% discount | Use the promo code: AGINGWELL15 | https://berkeleylife.pxf.io/c/6475525/3226696/31118Oxford Healthspan | Primeadine®, a plant-derived spermidine supplement | 10% off code: AGINGWELL | https://oxford-healthspan.myshopify.com/AgingWellJigsaw Health | Trusted supplements. “It's fun to feel good.” | Click the following link and use the discount code AGINGWELL for 10% off: https://www.jigsawhealth.com/?rfsn=8710089.1dddcf3&utm_source=refersion&utm_medium=affiliate&utm_campaign=8710089.1dddcf3KneeMo | A smart device programmed to reduce your knee pain and keep you moving. | Click the following link and use the discount code AGINGWELL15 for 15% off: https://thekneemo.com/ref/agingwellProlon | The Fasting Mimicking Diet (FMD) is a revolutionary five-day nutrition program scientifically formulated to mimic the effects of a prolonged water fast while still allowing nourishment - supporting the benefits of fasting without the challenges and risks that come from water-only fasts. | For the best available discount always use this link: https://prolonlife.com/theagingwellpodcastL-Nutra Health | The medical division of L-Nutra, focused on helping people manage and potentially reverse chronic health conditions, like type 2 diabetes, prediabetes, insulin resistance, and obesity, using personalized, lifestyle-based programs grounded in evidence, not prescriptions. | Use this link: https://l-nutrahealth.com/theagingwellpodcastFusionary Formulas | Combining Ayurvedic wisdom with Western science for optimal health support. | 15% off Code: AGINGWELL | https://fusionaryformulas.com?sca_ref=9678325.IHg5xYhdOzzke8ZrDr Lewis Nutrition | Fight neurodegeneration and cognitive decline with Daily Brain Care by Dr Lewis Nutrition—a proven daily formula designed to protect and restore brain function. | 10% off code: AGINGWELL or use the link: https://drlewisnutrition.com/AGINGWELLTruDiagnostic—Your source for epigenetic testing | 12% off Code: AGEWELL or use the link: https://shop.trudiagnostic.com/discount/AGEWELL*We receive commission on these purchases. Thank you.

In this video we cover what is endometriosis, where does it most commonly affect as well as the signs and symptoms of endometriosis.  Includes endometriosis pathology and theories, as well as how endometriosis is diagnosed and treated. PDFs available here:  https://rhesusmedicine.com/pages/gynecologyConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Buy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Endometriosis?0:07 Where does Endometriosis most commonly affect?1:04 Signs and Symptoms of Endometriosis2:47 Thoracic Endometriosis Syndrome3:29 Endometriosis Pathophysiology / Endometriosis Pathology Theories4:35 Endometriosis Diagnosis5:44 Endometriosis TreatmentLINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesBulletti, C., Coccia, M.E., Battistoni, S. and Borini, A. (2010) ‘Endometriosis and infertility', Journal of Assisted Reproduction and Genetics, 27(8), pp. 441–447. doi:10.1007/s10815-010-9436-1.Gałczyński, K., Jóźwik, M., Lewkowicz, D., Semczuk-Sikora, A. and Semczuk, A. (2019) ‘Ovarian endometrioma – a possible finding in adolescent girls and young women: a mini-review', Journal of Ovarian Research, 12(1), p. 104. doi:10.1186/s13048-019-0582-5.National Center for Biotechnology Information (NCBI) (2010) Endometriosis and infertility. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941592/.Wikipedia (2025) Endometriosis. Available at: https://en.wikipedia.org/wiki/Endometriosis#Epidemiology.BMJ Best Practice (2024) Endometriosis: diagnosis – approach. Available at: https://bestpractice.bmj.com/topics/en-gb/355/diagnosis-approach.GPnotebook (2024) Endometriosis. Available at: https://gpnotebook.com/en-gb/simplepage.cfm?ID=1301938182.Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2023) Endometriosis: symptoms. Available at: https://www.nichd.nih.gov/health/topics/endometri/conditioninfo/symptoms.Disclaimer: Please remember this video and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

* Boulder, Colorado's Planetarium Show on Christ's Birth: For Christmas, we're enjoying this classic Real Science Radio broadcast about the University of Colorado's Fiske Planetarium presentation of a live program, The Astronomical Star of Bethlehem, by amateur astronomer Gil Buller. From the planetarium's website, "This exciting program examines the sky at the time of the birth of Christ to see which astronomical phenomenon may have been the Star of Bethlehem." * Orbital Mechanics Help Identify the Star of Bethlehem: Using computer-generated images of the night sky in ancient Israel, this planetarium program does in great style what Bob Enyart's DVD does using more modest computer simulation software. Click to get Bob's classic DVD, The Planets, Stars, and The Bible. * The Materialist's Star Problem: You may enjoy the bulleted list at our rsr.org/list-of-star-formation-problems broadcast show page. And whereas unbelievers say that young-earth creationists have a "starlight and time" problem, remember, materialists have: 1) a star problem 2) a light problem 3) a time problem, and 4) an everything problem.

This episode covers Turner syndrome.Written notes can be found at https://zerotofinals.com/paediatrics/genetics/turner/Questions can be found at https://members.zerotofinals.com/Books can be found at https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

In this solo episode of The SuperLife Podcast, Darin Olien dives deep into the true biology of energy—not motivation, not stimulants, not willpower, but the mitochondria themselves. Inspired by a groundbreaking conversation between Dr. Andrew Huberman and Dr. Martin Picard, Darin reframes energy as an emergent property of how we live, not just what we eat or how much we sleep. This episode explores how mitochondria act as signal translators, listening to your food, stress, sleep, movement, emotions, purpose, and environment—and turning those signals into either vitality or depletion. Darin connects cutting-edge mitochondrial science with real-world practices around recovery, meaningful stress, consistency, connection, and alignment, showing how true longevity and resilience are built at the cellular level.     What You'll Learn in This Episode 00:00  – Welcome to SuperLife & the mission of sovereignty and vitality 00:32 – Thera Sage sponsor: family-built healing tech & red light 02:10 – Why this episode is different: diving into cellular energy 02:42 – Inspiration from Huberman & Picard's mitochondria conversation 03:11 – Rethinking mitochondria: not just ATP, but information processors 04:03 – Energy as potential for change, not calories or fuel 04:39 – How thoughts, emotions, food, and stress shape energy 05:05 – Energy is dynamic, adaptive, and responsive to how you live 06:02 – Mitochondria as signal integrators: sleep, hormones, purpose, connection 06:50 – Mitochondria as antennas, not factories 07:16 – Translating life experience into biological energy 08:09 – Why we don't feel "energy," we feel energy flow 08:53 – Flow states, purpose, and why passion creates vitality 09:32 – Different organs, different mitochondrial roles 10:26 – Why energy optimization is not one-size-fits-all 10:49 – Energy resistance: the hidden cause of fatigue and burnout 11:47 – Chronic stress, poor sleep, and ultra-processed food as energy blockers 12:12 – Why recovery is non-negotiable for longevity 12:20 – Caldera Lab sponsor: clean, performance-driven skincare 14:20 – The danger of constant output without recovery 14:45 – Sleep as a mitochondrial reset and repair system 15:40 – Exercise, adaptation, and why recovery completes the signal 16:22 – Intentional stress vs. chronic stress 17:29 – Food as information, not just fuel 18:05 – Time-restricted eating, fresh food, and metabolic signaling 18:27 – Meaning, purpose, and emotional states as cellular inputs 19:23 – Mitochondria, aging, and the potential reversibility of decline 20:06 – SuperLife framework: alignment over optimization 20:37 – Consistency beats intensity at the cellular level 21:19 – Stable rhythms: sleep, nourishment, hydration, movement 21:45 – Stillness, meditation, and parasympathetic repair 22:35 – Growth requires both resistance and recovery 24:44 – Connection, community, and loneliness as biological signals 25:27 – Eliminating fatal conveniences to restore vitality 26:02 – Your mitochondria are listening—change the signals 26:21 – Honoring Huberman & Picard's contribution to human health 27:12 – Energy flow as the foundation of a SuperLife 28:11 – Closing reflections and invitation to apply this work     Thank You to Our Sponsors Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Caldera Lab: Experience the clinically proven benefits of Caldera Lab's clean skincare regimen and enjoy 20% off your order by visiting calderalab.com/darin and using code DARIN at checkout.     Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences     Key Takeaway "Your mitochondria are not broken. They are responding perfectly to the signals you give them. Change the signals, and your energy, resilience, and life will follow."     Bibliography & Sources Here is the bibliography based on the sources referenced in the document, formatted with direct links to the scientific papers, books, and the podcast episode. Primary Source Material Huberman, A. (Host). (2025, December 15). Improve Energy & Longevity by Optimizing Mitochondria with Dr. Martin Picard [Audio/Video podcast]. Huberman Lab. Link to Episode Picard Lab. Mitochondrial Psychobiology Group. Columbia University Irving Medical Center. Link to Lab Website Key Scientific Literature & Books Hood, D. A., Memme, J. M., Oliveira, A. N., & Triolo, M. (2019). Exercise and Mitochondrial Biogenesis. Physiological Reviews, 99(1), 669–715. Read Study Lane, N. (2015). The Vital Question: Energy, Evolution, and the Origins of Complex Life. W.W. Norton & Company. Book Link López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The Hallmarks of Aging. Cell, 153(6), 1194–1217. Read Study Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018). Intermittent Metabolic Switching, Neuroplasticity and Brain Health. Nature Reviews Neuroscience, 19, 63–80. Read Study Picard, M., & McEwen, B. S. (2018). Psychological Stress and Mitochondria: A Systematic Review. Psychosomatic Medicine, 80(2), 126–140. Read Study Picard, M., & Shirihai, O. S. (2022). Mitochondrial Psychobiology: Foundations and Applications. Current Opinion in Behavioral Sciences, 43, 102–110. Read Study Speakman, J. R., & Selman, C. (2011). The Free-Radical Damage Theory: Accumulating Evidence Against a Simple Link. Trends in Ecology & Evolution, 26(1), 33–39. Read Study Wallace, D. C. (2015). Mitochondria and Cancer. Nature Reviews Cancer, 12, 685–698. (Note: Often referenced alongside his Annual Review of Genetics work on aging). Read Study

Podcast: Bites and Bytes PodcastEpisode: How AI, Data, and Digital Agronomy Will Reshape Our Food Systems with Serg MasisPub date: 2025-12-21Get Podcast Transcript →powered by Listen411 - fast audio-to-text and summarizationIn this episode, Kristin King sits down with Serg Masis, a data scientist at Syngenta, to explore how AI, data, and digital agronomy are reshaping modern agriculture (Agronomy is the science of how crops are grown—soil, climate, plants, and farming practices working together).Serg brings an engineering mindset to AI, explaining it less like science fiction and more like a murder mystery,  where multiple perspectives, incomplete information, and interpretation matter just as much as the data itself. Rather than treating AI as a black box, he breaks down how understanding why a system makes a decision is just as important as the decision itself.Together, they talk about decision-making in farming,unintended consequences in complex systems, and why changing one thing in agriculture often creates ripple effects elsewhere. If you're curious about how technology is quietly influencing what we grow, how we farm, and what ends up on our plates, this conversation will change the way you think about food and data.---------------Guest Contact InformationGuest Info — Serg MasisWebsite: https://www.serg.ai/#about-meBooks & Writing: https://www.serg.ai/writing/LinkedIn: https://www.linkedin.com/in/smasis/Employer (Syngenta): https://www.syngenta.com/---------------Episode Key Highlights00:11:00 — Why AI Is About Better Decision-Making, Not Replacing Humans00:13:19 — The Three Inputs of Agriculture: Environment, Genetics, and Decisions00:17:20 — Sustainability, Ecosystems, and Runaway Effects in Farming00:25:33 — AI as a Murder Mystery: Interpretation, Bias, and Perspective00:34:26 — Crop Collapse, Monocultures, and Why This Isn't Science Fiction---------------

(00:00-43:13) Not a best of, but let's make it one. Third shifters. Text in if you're armed and pissed. Barge Guy is back. Shout out everybody on the river. What's the Christmas meal for the boys on the barge? River's low. Alright, thank you Bargie. Uncle Rich tackled a cardboard cutout once thinking it was an intruder. Jackson's Christmas 'stache. Bring back the handlebar mustache. Journalism is what moves the nation. Bofa Deez is on the line. Bofa has been emotionally sick. The new wife left too. Maybe just stay single for a while. Porch pirates. Genetics you know, what a story.(43:21-52:54) Down on barbershop quartets. Mailboxes are federal property. Candy Cane Lane. Take heists. Is Tim safe? Daniel Stern. Lotta unhappy Mizzou basketball fans.(53:04-1:08:27) Michigan J Frog. JR is in studio soliciting non perishable food items. Martin was locked out this morning. JR is here to save the show. Working for the Suburban Journals back in the day and covering youth sports. Weird JeffCo kinks. Taking over on the Blues beat back in 05. Going to college bars.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Datis Kharrazian bridges complex science with practical strategies you can use right away, focusing on the fascinating concept of biological age versus chronological age.You'll learn why some people seem to age slower or faster than their years might suggest, and discover how factors like sleep, fasting, diet, and resilience are key to longevity and vibrant health. Datis Kharrazian dives into personalized clinical models, exploring mechanisms such as inflammation, cellular senescence, and genetic influences—and explains why resilience is the central feature in successful aging, healthspan, and overall wellness.Whether you're a healthcare professional looking to advance your functional medicine expertise or someone seeking effective strategies for chronic health challenges, this episode lays the groundwork for integrating functional medicine and geroscience into everyday practice. Learn functional longevity strategies from Dr. Datis Kharrazian. Discover how to use personalized nutrition, diet, and lifestyle approaches to optimize healthspan. Enroll in the Longevity Mastery Program at: https://pages.kharrazianinstitute.com/longevityFor patient-oriented functional medicine courses, visit https://drknews.com/online-courses/For practitioner functional medicine certification courses, visit https://kharrazianinstitute.com/For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/00:00 "Biological vs. Chronological Age"04:25 "Inflammaging and Cellular Health Strategies"08:49 "Resilience: Key to Longevity"12:03 "Intermittent Fasting and Longevity"13:00 "Longevity Research and Key Pathways"19:25 "Genetics and Resilience in Aging"21:03 "Resilience: Key to Healthy Aging"23:23 "Enhancing Resiliency Through Geroscience"27:39 "Inflammatory Resiliency and Intolerances"30:40 "Geroscience: Aging and Resilience"Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode of Shift with CJ, I sit down with Dr. Ebenezer Abel Paul, founder of Verve Wellness Dubai, to break down one of the biggest questions in health and longevity: If our genes are fixed, why are we all so different—and how much control do we really have?We take genetics out of the abstract and bring it down to first principles. Why some people tolerate carbs better. Why others struggle with dairy, stress, or weight. Why environment, culture, and modern city life (especially Dubai) can either switch on disease or unlock performance.Dr. Ebenezer explains genetics in a practical way: Your genotype is your blueprint. It doesn't change. Your phenotype—how those genes express—is shaped by lifestyle, food, sleep, stress, environment, and decisions made daily.We dive into why “it runs in my family” is often a misunderstanding of lifestyle patterns rather than destiny, using examples like type 2 diabetes, lactose intolerance, obesity risk, and stress sensitivity. The episode also explores how modern stress, poor sleep, ultra-processed food, eating out culture, microplastics, EMFs, and vitamin deficiencies silently alter gene expression.We discuss the Well Gene Book as an entry point into personalized medicine—not as a diagnosis tool, but as a lifelong blueprint to make better decisions. Dr. Ebenezer explains why combining genetics with blood work, gut health, proteomics, and lifestyle data creates true precision health—and why random supplements, generic diets, or self-diagnosing with AI can backfire.The future, according to Dr. Ebenezer, is not shortcuts—but data harmonization: genetics + lifestyle + environment + AI-guided decision-making, all personalized to the individual.Key TakeawaysGenetics load the gun, lifestyle pulls the trigger.Most “genetic diseases” are actually lifestyle-driven expressions.Modern city life creates a mismatch between biology and environment.Food intolerances often show up as fatigue, brain fog, skin issues—not just gut symptoms.Personalized health beats generic diets, workouts, and supplements every time.5 Things You Can Start Doing TodayStop copying diets — eat based on how you respond, not influencers.Question symptoms like bloating, fatigue, brain fog—they're signals, not normal.Fix sleep first — poor sleep amplifies stress genes and inflammation.Reduce eating out — unknown oils, reheated food, and plastics matter.Use data wisely — genetics guide decisions, blood work confirms reality.Knowledge doesn't remove responsibility—it gives you control.

Are you a parent at the end of your rope dealing with your child's complex neurological challenges like tics, Tourette's, ADHD or anxiety?Today, we welcome pioneering functional health expert Dr Piper Gibson, founder of the Regenerating Health and Tic Disorder Institute. Dr Gibson shares her powerful, research-backed journey of helping her own son overcome a transient neurological tic disorder and how she now empowers families globally with a holistic, root-cause approach. Discover why symptoms like tics and anxiety are not random and how underlying issues like gut dysfunction, a dysregulated immune system, environmental toxins and genetics are the true drivers.Key Information 02:33 Discover why neurological symptoms like tics, ADHD and anxiety are not random and how these issues are linked to a dysregulated immune system and root causes beyond typical neurological labels.03:44 Parents often miss the underlying issues (like gut problems, genetics and toxicity) that conventional research overlooks. Learn why treatments must go beyond simple probiotics to address parasites, leaky gut and chronic inflammation.04:51 Understand the powerful and often-overlooked gut-brain axis. Dr Gibson explains how inflammation and leaky gut allow pathogens into the bloodstream, triggering immune cells in the brain and driving neurological symptoms.06:45 Dr Gibson outlines her protocol: first, clean up the environment and change the diet. She emphasizes that detoxing too early on an unsupported gut and body can actually worsen symptoms.10:19 Learn about the specific lab tests used to uncover root causes, including PCR stool pathogen tests, organic acids testing, tests for environmental toxins/heavy metals/mycotoxins (mold) and detailed genetic panels (MTHFR, methylation). 13:09 Genetics are not set in stone. Dr Gibson explains epigenetics, showing how parents can manipulate the child's environment (diet, toxins, supplements) to influence gene expression and effectively "turn off" symptomatic neurological genes. 27:16 #1 Tip: Dr Gibson's top initial tip is to drastically reduce inflammatory sugar and processed foods to immediately support the gut-brain connection and begin the healing process. Piper's Bio Dr Piper Gibson, PhD is a pioneering voice in functional and natural health, specializing in complex neurological conditions like tic disorders, ADHD, and anxiety in children. As the founder of Regenerating Health and the Tic Disorder Institute, she empowers families who are at the end of their rope, offering a research-backed, holistic approach that goes far beyond symptom management. Through advanced lab testing, genetics, and personalized nutrition, she helps uncover the root causes of children's health challenges. Dr Gibson's work blends deep scientific understanding with a compassionate, supportive framework, giving parents a roadmap to help their kids thrive—naturally.Connect with Piper https://www.regenerating.health/Facebook: https://www.facebook.com/RegeneratingHealthInstagram: https://www.instagram.com/regeneratinghealth/LinkedIn: https://www.linkedin.com/in/drpipergibson/YouTube: https://www.youtube.com/@ticdisordersecretsWho am I?Sarah Dawkins is a passionate Holistic Health and Healing Coach, international speaker and author of Heal Yourself. She's also a multi-award-winning entrepreneur and the award-winning host of the uplifting podcast Heal Yourself with Sarah Dawkins.With over 20 years' experience as a Registered Nurse, Sarah combines her deep understanding of conventional medicine with her own powerful self-healing journey to create a truly integrative approach. Having overcome multiple chronic health challenges herself, she now supports others in uncovering and addressing the root causes of their symptoms, helping them restore balance, reclaim their energy and create lasting, vibrant wellness.www.sarahdawkins.com#NeurologicalDisorders #Tics #TourettesSyndrome #ADHD #OCD

This episode features Dr. Jocelyn Johnson with STgenetics, a speaker at the 2025 ADSA Breeding and Genetics Symposium: Creating Carbon-Friendly Cows and Leveraging Omics to Improve the Sustainability of Dairy Production.Dr. Johnson's presentation was titled “Advancing dairy sustainability through feed-efficient genetics and genomics: Research insights and applications.” She gives an overview of her talk, which focused on data STgenetics has collected and how the company has applied that data to help their customers be more sustainable. She goes on to describe some of the residual feed intake research they've conducted in dairy cows. (4:20)STgenetics has invested in feed efficiency technology and has shown that selection for improved feed efficiency is correlated to a lower carbon footprint. Dr. Johnson talks about the heritability of feed efficiency compared to other traits we select for in the dairy industry.  (8:16)Dr. Pralle asks Dr. Johnson if STgenetics is measuring emissions from cows in their research. The company has partnered with Texas A&M to measure methane emissions in heifers divergently selected for feed efficiency. They found that more efficient animals produced less methane. Since that pilot project, STgenetics has purchased equipment to measure emissions at their own research facilities and has collected 2-3 years of data on beef, beef on dairy, and Holstein populations. Dr. Johnson emphasizes that the relationship between methane emissions and high milk production is somewhat of a balancing act. (11:29)The group discusses feed additives purported to decrease methane emissions and the differences in rumen microbiomes between high and low efficiency animals. They also talk about how best to get information and technology in front of producers.  (17:59)Panelists share their take-home thoughts. (23:39)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

In this episode, recorded live at the World Dairy Expo, Peggy sits down with Tim Baumgartner, the genetics manager at Jer-Z-Boyz Ranch in Pixley, California. Tim shares his journey from growing up on a dairy farm in Wisconsin to becoming a pivotal figure in the dairy genetics industry. He discusses his passion for cows and people, recounting how one pivotal conversation led to a rewarding career in genetics. The episode explores how the Jer-Z-Boyz Ranch significantly improved the breed's genetics, the impact of mentorship, and how innovative technology, like the Milc Group's feed program, transformed their operations. Highlights include the discovery and development of high-fat Jersey cows, the challenge and success of polled genetics, and the importance of family and community in the dairy world. Tim's story is a testament to resilience, passion, and the pursuit of excellence in the dairy industry.This Episode is Brought to you by Milc GroupMilc Group is a dairy software company that brings real-time, actionable data to dairy farms across the world. They are dedicated to revolutionizing the dairy industry with their user-friendly cloud-based software. ONE™ by Milc Group is our all-in-one app that brings together all the important aspects of your dairy together in one place. With products such as feed and animal management software, people training, dairy facility monitoring, and scale management, Milc Group is committed to providing producers with the tools they need to succeed.ONETM Feed: https://www.milcgroup.com/product/feedONETM Scale: https://www.milcgroup.com/product/scale00:00 Introduction: Shaping a Breed and Leaving a Legacy00:07 Meet Tim Baumgartner: A Passion for Genetics01:23 Growing Up on a Dairy Farm in Wisconsin07:42 The Journey to California09:31 A Career in Genetics and Mentorship15:37 The Jer-Z-Boyz Ranch Transformation27:39 Innovations and Future Directions

Conversation with Joe Messer starts at 2:20. California Spring Trials 2026: March 24-27 (Days and time may vary by location.) https://caspringtrials.us/ Tech On Demand host (and 20-year trials veteran) Bill Calkins collaborated with California Spring Trials registration managers at National Garden Bureau to produce a series of podcasts featuring representatives from just about every exhibiting company in an effort to get you excited about the iconic industry event and some of the new plant introductions you'll see on display in spring of 2026. California Spring Trials is the horticulture industry's “fashion week” and with more than two dozen participating companies bringing hundreds of new plants to market for 2027 and beyond, opportunities to get inspired and plan new additions to your crop mix abound! Registration for this annual even is essential to help hosts create an amazing, customized experience for all attendees. REGISTER FOR CAST 2026 NOW AT https://caspringtrials.us/. You'll also find a trip planner, location information and more. Be sure to schedule plenty of time at each stop and with each exhibiting company!

Send us a textSubscribe and unleash your inner science goblin. We see you. We respect it.DNA isn't magic—but it is one of the most powerful instruction systems in the universe.In this deep-dive episode of Wildly Curious, Katy Reiss and Laura Fawks Lapole break down genetics, DNA, and inheritance in a way that actually makes sense—no lab coat required. From the tiny molecular code inside your cells to the ethical questions surrounding modern gene editing, this episode connects the science to real life.

A conversation with Dr. Andrés Moreno Estrada We are honored to share a compelling conversation with Dr. Andrés Moreno Estrada, a renowned geneticist whose work is transforming how we understand human diversity, ancestry, and health. In [...]

This episode covers Klinefelter syndrome.Written notes can be found at https://zerotofinals.com/paediatrics/genetics/klinefelter/Questions can be found at https://members.zerotofinals.com/Books can be found at https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

In this episode of the Flex Diet Podcast, I sit down with Dr. Lauren Colenso-Semple to cut through the noise and tackle some of the most persistent myths in women's fitness. We break down where misinformation shows up in popular programs, why overly complicated plans often backfire, and what the science actually says about fasted training and low energy availability. We also get into hot topics like cold water immersion and cortisol, real sex-based differences in training responses, and why women's fitness research is still so challenging to conduct well. If you're looking for practical, evidence-based guidance instead of hype, this episode will help you train smarter and with more confidence.Sponsors:LMNT: http://drinklmnt.com/mikenelson (automatically applied at checkout)Beyond Power Voltra 1: https://www.beyond-power.com/michael13Fitness Insider Newsletter: https://miketnelson.com/Episode Chapters:04:30 Interview with Dr. Lauren Colenso-Semple05:01 Complications in Women's Fitness07:39 Effective Training Strategies18:42 Fasted Training for Women23:33 Low Energy Availability28:50 Cold Water Immersion for Women34:27 The Overemphasis on Recovery36:45 Sex-Based Differences in Training37:04 The Fiber Type Debate43:41 Genetics and Athletic Performance46:23 Women's Specific Supplements53:50 Challenges in Women's Fitness Research01:00:51 Rapid Fire Questions and ConclusionEpisodes You Might Enjoy:Episode 267: Demystifying Women's Fitness and Nutrition with Alli FahrenbachYouTube: https://youtu.be/w13NXowjSVU?si=QDdKNRGZZq_SgT5hEpisode 296: Enhancing Athletic Performance with Dr. Dani LaMartinaYouTube: https://youtu.be/ts_eqvs6OI4?si=TiqFPjcsxI9a3owFConnect with Dr Lauren Colenso-Semple:Website: https://www.drlaurencs.com/Instagram: https://www.instagram.com/drlaurencs1Get In Touch:Instagram: https://www.instagram.com/drmiketnelson/YouTube: https://www.youtube.com/channel/UCn1aTbQqHglfNrENPm0GTpgEmail: https://miketnelson.com/contact-us/

What's better than covering a sale of clubby females that are as good as any in the industry? Rockin H entrusted us to cover their entire sale, and it's flat awesome. There's so much variation in type and kinds, color, and opportunities. Rockin H has been working hard to build a reliable program, and they have sure done that! There's a special one at the end that we all believe is a pretty special show heifer! Find it on SteerBidder, it all happens on the 29th! Empowerment Is Here. Link

Send us a textEpisode 142 of the Joint Dynamics Podcast JD host Andrew Cox | Joint Dynamics features Mariano García-Valiño. Mariano is a four-time health-tech entrepreneur and CEO of Axenya, a company revolutionizing healthcare with AI, advanced software, data science, and human-centered support. Mariano has led the creation, scaling, and exit of major companies including a $9 billion sale and a $1 billion IPO, with earlier roles at Pfizer, Lilly, McKinsey, and global investment firms. Beyond his business acumen, Mariano supports his drive and innovative mindset via his dedication to meditation and his work as an experimental art photographer, blending creativity and mindfulness to fuel his leadership. He is also the Amazon #1 bestselling author of "INEDIBLE," which explores why healthcare lags in technology adoption and how to fix it. Mariano holds an Engineering degree from Universidad de Buenos Aires and an MBA from Harvard Business School earned on a Fulbright Scholarship, underscoring his diverse expertise in entrepreneurship, technology, and human-centered innovation.Quick recap*Show sponsor is Muvitality Medicinal Mushrooms for modern day health and wellness | Mu …Go to muvitality.com and use the code JD10 to receive a 10% discount on your purchase of Mu Functional mushrooms such as Lions Mane, Cordyceps, Chaga, Reishi, and Turkey tail functional mushroomsEnjoyHere are some useful links for this podcastMariano's Book - Software is eating the world, yet healthcare remains INEDIBLE: How to Build the Modern, Tech-Enabled, Healthcare Experience - https://www.amazon.com/Software-eating-healthcare-remains-INEDIBLE-ebook/dp/B0FVGLQ1QF?ref_=ast_author_dp&th=1&psc=1www.mgarciavalino.comRelevant episodesEpisode 122 - Dr Christine Houghton on Genetics, Nutritional Biochemistry & Sulforaphane https://podcasts.apple.com/hk/podcast/episode-122-dr-christine-houghton-on-genetics-nutritional/id1527374894?i=1000699475907JOINT DYNAMICS links:Joint Dynamics Facebook - https://www.facebook.com/JointDynamicsHongKong/Joint Dynamics Instagram -https://www.instagram.com/jointdynamics/Joint Dynamics Youtube - https://www.youtube.com/channel/UCRQZplKxZMSvtc6LxM5WckwJoint Dynamics Website - www.jointdynamics.com.hk Host - Andrew Cox - https://www.jointdynamics.com.hk/the-team/trainers/andrew-cox

Guests:Kate Adamala, Associate Professor of Genetics, Cell Biology, and Development at the University of MinnesotaGlyn Tallon, Founder of Tallon Mortuary Specialists in Navan

Nspecta of CSI Humboldt and Bodhi join Matthew Riot of Riot Seeds to Present, Review and Discuss "The Cannabible" by Jason King, Book 2 (the red one). Part 2. Educational, historical, & public interest used with permission by the author.

We dig into why visceral fat drives disease risk, how to spot it on sight and imaging, and the levers that shrink it without losing muscle. We map a practical plan across food, fasting, light, stress, and training, and weigh GLP-1s and surgery against lifestyle-first care.Christopher J. Stadtherr, MD is a board-certified physician in Family Medicine and Obesity Medicine, with expertise in nutrition and metabolic health.  He practices metabolic medicine in a direct primary care (DPC) model out of Gig Harbour, WA, USA and is committed to helping his patients reverse their diabetes, improve their metabolic health, and avoid the myriad complications that necessitate hospitalization.CONSULT DR MAXInitial consult - https://www.drmaxgulhane.com/offers/5jfDvLyH/checkoutSUPPORT MY WORK

* Dino Dave: This week Fred Williams and Doug McBurney welcome Dave Woetzel of Dino Dave fame on YouTube, at Genesis Park, in churches, globally (and beyond)!   *Tune in to YouTube for the FULL Video: The full video (parts 1 and 2) will be released soon on the RSR YouTube Channel.   * Origins, Giants and the Bible: Hear how stories of giants in the Bible, (along with extra biblical legends) and the fossil record of giant organisms confirm Biblical creation.   * Antediluvian Giants: Who were the "sons of God" who took the daughters of men as wives in Genesis 6:2? Who were the "mighty men" and "men of renown in verse 4?" Were the pre-flood giants the offspring of fallen angels or men? Hear about the three common views: the Regal, Sethite and Fallen Angel theories of just who these giants were.   * Post Flood Giants: How and why did the giants of the pre-flood world seem to reappear in the Promised Land while Israel was in Egypt and afterward, all the way up to the time of King David.   * Goliath: Hear about the difference between a biblical giant like Goliath and modern "giants" like Robert Wadlow who suffered from gigantism, (along with archaeological confirmation of ancient weapons like those described in the Bible)!   * American Giants? Hear Dave begin to discuss how he got interested in Giants from reading a book called The Ancient Giants who Ruled America on a trip to the mound-builder capital of St Louis.

This episode covers Down syndrome.Written notes can be found at https://zerotofinals.com/paediatrics/genetics/downs/Questions can be found at https://members.zerotofinals.com/Books can be found at https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

Send us a textOn today's episode of The Myopia Podcast:How he got started in optometry. The reason behind his passion in Myopia Management. What it's like to be a high myope.How genetics affect myopia in children. What are some ways to encourage children to spend time outdoors. I hope you learned a lot from this episode.About Dr. Tim Earley:Dr. Timothy Earley obtained his B.S. in Biology from the University of Scranton in 1994.He then obtained both a B.S. in Visual Science and a Doctorate in Optometry from thePennsylvania College of Optometry in 1998. After graduation, he joined the MedinaVision and Laser Centre, where he served as a therapeutic optometrist until December2020 when he joined Northeast Ohio Eye Surgeons. He spent 23 years as the vicepresident/secretary of Medina Vision Centre and was the director of human resources.Dr. Earley has a special interest in the diagnosis and management of age-relatedmacular degeneration (AMD), dry eye and ocular surface disease, co-management ofcataract and refractive surgery, and the fitting of multifocal and specialty contact lenses.Reflecting his commitment to public health, Dr. Earley is the Clinic Director of the BrightEyedeas Vision Clinic. At Bright Eyedeas, high school students enrolled in the opticaltechnology/visual sciences program work with Dr. Earley to provide no-cost eyeexaminations and eyeglasses for patients in need. He also participates in InfantSEE, apublic health program designed to ensure that vision care becomes an essential part ofinfant wellness.Dr. Earley is a member of the American Optometric Association and the OhioOptometric Association. He is also a national speaker and consultant in the areas ofspecialty contact lenses, macular degeneration, and practice management. He is aconsultant for Alcon and a member of the Practitioner's Visiting Alcon (PVA) faculty. Dr.Earley serves as a KOL for Notal Vision, and is currently on the Speaker Bureau and isa KOL for Maculogix and MacuHealth. Dr. Earley has been published in OptometricManagement, Advanced Ocular Care, and Review of Optometry, and is a COPEapproved continuing education lecturer. He currently contributes a Business Strategiescolumn for Optometric Management and serves on its editorial advisory board.When not seeing patients or consulting with industry partners, Dr. Earley enjoysspending time with his wife, Dr. Andrea Earley, and his three children. He enjoys theoutdoors, hiking, golfing, and gardening. He has a small flock of chickens and hopes toexpand his hobby farm in the future.---If you're considering or have ever considered getting a virtual team member for your practice check out hiredteem.com, mention The Myopia Podcast when signing up for a $250 dollar discount off of your first month's teem member.https://hireteem.com/myopia-podcast/

Send us a textHow seasonal changes in light and dietary unsaturated fats affect circadian rhythms in mammals.Topics Discussed:Evolutionary context of circadian rhythms: All organisms have adapted to Earth's 24-hour day for survival, with internal clocks slightly offset and adjusted by environmental cues.Molecular clock mechanism: Involves a feedback loop where proteins turn on/off genes, lasting ~24 hours, regulated by phosphorylation and degradation for timing precision.Genetic variations in sleep: Families with mutations in clock genes like PER2 cause extreme morning lark behavior, altering protein stability and period length by hours.Light entrainment: Morning light shortens human clocks (average 24.2 hours) to match 24-hour days; seasonal day length changes require gradual adjustments.Food & metabolic links: Seasonal food scarcity/abundance affects clock via glucose and fatty acids competing for protein modifications, as shown in diabetic mouse models.Role of unsaturated fats: Paper finds MUFA/PUFA ratios in diet alter phosphorylation of clock proteins, speeding or slowing adaptation to winter/summer light cycles in mice.Modern environmental impacts: Artificial light extends “daytime” signals, while constant food access erases seasonal patterns, contributing to obesity and diabetes risks.Jet lag & adaptations: Sudden time shifts mimic seasonal experiments; high-sugar/fat intake may phenocopy genetic effects to aid adjustment, though not recommended for health.Practical Takeaways:Expose yourself to morning natural light to help synchronize your internal clock and improve daily energy.Consume main meals during daylight hours and avoid late-night eating to align with natural metabolic rhythms.Limit evening screen time to reduce artificial blue light disrupting sleep onset.Consider varying diet seasonally, favoring diverse, whole foods to mimic natural availability patterns for better health.About the guest: Louis Ptacek, MD is a neurologist and professor at the University of California, San Francisco. He researches inherited neurological diseases and sleep traits, including genetic variations causing extreme early rising.Related Episode:M&M 237: Circadian Biology: Genetics, Behavior, Metabolism, Light, Oxygen & Melatonin | Joseph Takahashi*Not medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Overview This special episode of the [Tick Boot Camp Podcast](https://tickbootcamp.com/podcast/) was recorded live at the 2nd Annual Alzheimer's Pathobiome Initiative (AlzPI) and PCOM Symposium in collaboration with Pathobiome Perspectives. Hosted by Ali Moresco in partnership with Nikki Schultek, Executive Director of AlzPI, the conversation continues the Tick Boot Camp mission of exploring infection-associated chronic illness (IACI)—including Lyme disease and other tick-borne infections—within the global Alzheimer's and neuroimmunology research community. Tick Boot Camp co-founders Matt Sabatello and Rich Johannesen partnered with Ali and Nikki to highlight leading scientists connecting microbes, immune dysregulation, and neurodegenerative disease. This episode features Dr. Elizabeth “Betsy” Bradshaw, Assistant Professor of Neurology at Columbia University Irving Medical Center, whose research investigates how past infections leave lasting imprints on the brain's immune system and influence the development of Alzheimer's disease. Guest Elizabeth M. Bradshaw, PhD Assistant Professor of Neurology, Columbia University Irving Medical Center Principal Investigator, Bradshaw Laboratory – Neuroimmunology and Genetics of Alzheimer's Dr. Bradshaw's laboratory focuses on the immune system's role in neurodegeneration, particularly how infection and inflammation alter brain immunity and predispose individuals to conditions like Alzheimer's disease. Her work builds on large-scale genome-wide association studies (GWAS) that identified immune-related genetic variants linked to Alzheimer's susceptibility, suggesting that subtle changes in immune function—not just neuronal factors—may underlie disease onset. Her team is exploring how pathogens such as HSV-1 (Herpes Simplex Virus Type 1) interact with the brain's immune cells, known as microglia, and how these infections can “reprogram” immune responses long after the pathogen is cleared. Key Discussion Points Dr. Bradshaw explains how her research bridges genetics, immunology, and infectious disease to better understand Alzheimer's. Through GWAS data, her team found that many of the genes linked to Alzheimer's risk involve immune pathways rather than neuronal signaling. This discovery redirected the field's attention toward how immune cells respond to pathogens and environmental stressors across a lifetime. Using human-derived microglia-like cells created from blood monocytes, her team observes how infections reshape immune cell metabolism and memory. By infecting these microglia-like cells with Alzheimer's-associated pathogens like HSV-1, they study how genetic background and infection history determine immune cell behavior. The findings suggest that past infections may epigenetically and metabolically train microglia—changing how they respond to aging, stress, and amyloid buildup. Even when the infection has resolved, these “reprogrammed” immune cells can remain altered for decades, silently increasing the brain's vulnerability to neurodegeneration. Dr. Bradshaw emphasizes that understanding how infections rewire the brain's immune landscape could transform early intervention strategies. Identifying combinations of genetic risk factors and pathogen exposures may enable targeted prevention or immune-modulating treatments long before symptoms appear. “Microglia remember. Even after the pathogen is gone, they carry its imprint—responding differently decades later when the brain faces new challenges.” — Dr. Elizabeth Bradshaw Why It Matters Dr. Bradshaw's work reframes Alzheimer's disease as a neuroimmune condition shaped by infection and host genetics. Her research highlights how microbial exposures, immune history, and inflammation converge to influence cognitive decline. By integrating infection biology with genetics and immunology, her team is redefining how scientists and clinicians view the root causes of Alzheimer's and other neurodegenerative diseases. This work strengthens the growing case that the immune system's “memory” of infection may be one of the most important and overlooked factors in brain health and aging. About the Event This interview was recorded at the 2nd Annual Alzheimer's Pathobiome Initiative (AlzPI) and Philadelphia College of Osteopathic Medicine (PCOM) Symposium, held October 3, 2025, at Ohio University in Dublin, Ohio. The event brought together more than 20 leading researchers exploring how microbes, the microbiome, and immune dysregulation contribute to Alzheimer's, dementia, and infection-associated chronic illness (IACI). Tick Boot Camp partnered with Ali Moresco and Nikki Schultek to share these conversations and connect chronic Lyme, infection, and neurodegenerative research communities. Learn More Learn more about the Alzheimer's Pathobiome Initiative (AlzPI) Listen to Tick Boot Camp Podcast episodes, including Episode 406: Pathobiome – An Interview with Nikki Schultek and Episode 101: The Young Gun – An Interview with Alex (Ali) Moresco discussed in this interview.

Dr. David Agus, USC Professor of Medicine and CEO of the Ellison Institute for Transformative Medicine, treats presidents, CEOs and cultural icons and has spent decades studying one question: What determines how long and well we live?His answer is hopeful: Only 4% is genetic. The other 96% is under your control.In this episode, he reveals why elephants rarely get cancer, why giraffes never get heart disease, and what inflammation does to nearly every organ in your body. He also shares the simple, proven habits that matter more than DNA, and destroys the myths quietly harming millions.Science-backed. Actionable. Hopeful.

This epsiode is brought ot you by LMNT, Strong Coffee Company, Legion Athletics and Fatty15. After healing from Hodgkin's lymphoma in her 30s, Elissa Goodman turned her personal health crisis into a lifelong mission: helping others prevent and recover from cancer through holistic nutrition and mindful living. In this episode, she opens up about her journey from stress-driven corporate life to deep healing through green juicing, plant-based eating, and inner work like yoga, trauma release, and plant medicine. Elissa discusses how trauma, inflammation, and our toxic environment create the "cancer terrain"—and how we can reverse it with simple, nutrient-dense habits and radical self-love. Her story is not just about healing cancer but transforming one's entire way of living. Follow Elissa @elissagoodman Follow Chase @chase_chewning ----- 00:00 – The Current Cancer Epidemic 03:00 – Diagnosis at 32 & Discovering Juicing 07:00 – Taking Healing into Her Own Hands 11:00 – The Power of One Question: "Are You Happy?" 15:00 – Losing Her Husband & What Holistic Healing Taught Her 21:00 – Top Anti-Cancer Foods & The Inflammation Connection 28:00 - Cacao, Grief, and Plant Medicine as Emotional Healing Tools 33:00 - The Cancer Terrain: Internal Environment vs. Genetics 38:00 - Detoxification Basics: Sweat, Sleep, & Simplicity 43:00 - Myths About Juicing, Water Fasting, and Sugar ----- Episode resources: Get a FREE electrolyte variety mix with any purchase at https://www.DrinkLMNT.com/everforward Save 15% on organic coffee and lattes wiht code CHASE at https://www.StrongCoffeeCompany.com  Get an additional 15% off the 90-day starter kit of C15:0 essential fatty acids at https://www.Fatty15.com/everforward Get 20% off your entire first purhcase with code EVERFORWARD at https://www.LegionAthletics.com  Watch and subscribe on YouTube

In this conversation, we connect with Bob Gilpatrick to explore the science of longevity, epigenetic reprogramming, holistic wellness, and the future of anti-aging breakthroughs. Bob is the President and Co-Founder of Boomers Forever Young, an anti-aging and nutrition company, and brings more than 20 years of experience as a Holistic Health Therapist. He is also a Certified Holistic Nutritionist, a Heart-Centered Therapist, and a trusted guide for individuals seeking advanced nutritional strategies. Bob is widely known for his ability to explain complex aspects of aging in simple, accessible language — shedding light on topics rarely discussed in mainstream health conversations. He also provides insight into revolutionary nutritional technologies designed to support deeper healing and improved longevity. Throughout his career, Bob has trained with many of the world's leading holistic health pioneers. His work focuses on nutritional consulting, with a special emphasis on supporting individuals with diabetes, weight-loss goals, and intestinal disorders.   Listen in to find out: What epigenetics are, and what it means to reprogram them. The role that gaining muscle plays in overall health and longevity.  How to leverage various "de-aging" mechanisms. The new anti-aging technologies that are shaping the future of personal health. Keep up with Bob and his work on LinkedIn!

In this deeply vulnerable solo episode, Darin dismantles one of the great myths of modern self-help: that transformation is something you're meant to "do alone." Drawing from neuroscience, anthropology, physiology, and personal experience, he reveals the biological truth — the human nervous system is designed to heal, grow, and stabilize in relationship, not isolation. This conversation explores why loneliness creates physiological damage, why belonging is a survival requirement (not a luxury), and how to intentionally rebuild the village your cells have been waiting for. If you've ever felt like you're doing all the "inner work" but still feel disconnected, this episode is the medicine.     What You'll Learn in This Episode 00:00:00 - Opening SuperLife intro narration. 00:00:32 - Sponsor: Therasage — family-driven healing technology, infrared and natural frequency support, details on discount. 00:02:11 - Darin begins the episode — "You were never meant to do this alone." 00:02:22 - The forgotten biology of community and why humans are not built for isolation. 00:03:01 - Your nervous system regulates in relationship — the vagus nerve, safety, co-regulation. 00:03:19 - Social engagement system — coherence, cortisol regulation, belonging as biology. 00:04:03 - Social pain = physical pain; the Baumeister research; the architecture of human connection. 00:05:01 - Tribes, proximity, shared life — Dunbar's number and the limits of real human networks. 00:05:30 - Loneliness as physiology — cortisol elevation, inflammation, disrupted sleep, gray-matter changes. 00:07:01 - Personal growth was never meant to be personal — autonomy, competence, relatedness, love. 00:07:55 - If nobody sees you, your nervous system can't relax — mirrors vs willpower. 00:08:31 - Social contagion of behavior — your network shapes your health. 00:09:01 - Who are you wired into? Environment as epigenetic instruction. 00:10:12 - Why online spaces generate stress instead of transformation. 00:10:35 - Darin's vision: community as a practice, not performance. 00:11:29 - Sponsor: Bite Toothpaste — plastic waste, sustainability, clean ingredients, discount code. 00:13:11 - What if growth wasn't a grind? What if healing was tribal again? 00:13:35 - Building intentional space — not fandom, not following, but practice. 00:14:11 - Supporting the nervous system through community; truth over scrolling. 00:15:04 - Why Patreon — structure, privacy, belonging, circle not feed. 00:15:23 - People looking for truth, depth, real connection — not performance. 00:15:51 - Start building your circle; align with those who align with you. 00:16:12 - You need to be seen, not fixed — community as transformation. 00:17:00 - One person can change your life — the power of being mirrored. 00:17:31 - Men's group, friendships, working out — the daily relational fabric. 00:18:01 - If you're lonely or disconnected, the desire for connection already shifts your biology. 00:18:41 - Darin reflects on a hard year, pain, stem cells, and the deeper healing found in being witnessed. 00:19:26 - Every cell responds when you say yes to deeper connection — the universe moves with it. 00:20:07 - Understanding human biology: we want love, connection, safety, belonging. 00:20:36 - Cutting through "what do you eat" questions — the real priority is connection. 00:21:00 - Closing: "Joy and happiness. Connection. We are built for it… I love you."     Thank You to Our Sponsors Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order.     Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only  $7.49/month at https://patreon.com/darinolien     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences     Key Takeaway "You don't need to be fixed. You don't need to be saved. You just need to be seen — and we cannot do that alone."     Bibliography Neuroscience & Biology of Connection Porges, S. W. (2011). The Polyvagal Theory: Neurophysiological Foundations of Emotions, Attachment, Communication, and Self-Regulation. New York: W.W. Norton. Link to Book Information (Norton) Lieberman, M. D. (2013). Social: Why Our Brains Are Wired to Connect. New York: Crown Publishers. Link to Book Information (Penguin Random House) Eisenberger, N. I. (2012). "The pain of social disconnection: examining the shared neural underpinnings of physical and social pain." Nature Reviews Neuroscience, 13(6), 421–434. Link to Study (PubMed) Thayer, J. F. & Lane, R. D. (2000). "A model of neurovisceral integration in emotion regulation and dysregulation." Journal of Affective Disorders, 61(3), 201–216. Link to Study (ScienceDirect) Psychology of Belonging & Motivation Baumeister, R. F. & Leary, M. R. (1995). "The need to belong: desire for interpersonal attachments as a fundamental human motivation." Psychological Bulletin, 117(3), 497–529. Link to Study (PubMed) Deci, E. L. & Ryan, R. M. (2000). "The 'what' and 'why' of goal pursuits: Human needs and the self-determination of behavior." Psychological Inquiry, 11(4), 227-268. Link to Study (SelfDeterminationTheory.org) Adler, A. (1930s). What Life Could Mean to You. Link to Book Information (Google Books) (Note: Various editions exist) Social Networks & Behavioral Contagion Christakis, N. A. & Fowler, J. H. (2007). "The spread of obesity in a large social network over 32 years." New England Journal of Medicine, 357, 370-379. Link to Study (NEJM) Fowler, J. H. & Christakis, N. A. (2008). "Dynamic spread of happiness in a large social network." BMJ, 337, a2338. Link to Study (BMJ) Centola, D. (2018). How Behavior Spreads: The Science of Complex Contagions. Princeton University Press. Link to Book Information (Princeton University Press) Anthropology & Human Ecology Dunbar, R. I. M. (1992). "Neocortex size as a constraint on group size in primates." Journal of Human Evolution, 22(6), 469-493. Link to Study (ScienceDirect) Henrich, J. (2016). The Secret of Our Success: How Culture Is Driving Human Evolution, Domesticating Our Species, and Making Us Smarter. Princeton University Press. Link to Book Information (Princeton University Press) Loneliness, Inflammation & Health Outcomes Holt-Lunstad, J. et al. (2010). "Social relationships and mortality risk: a meta-analytic review." PLoS Medicine, 7(7), e1000316. Link to Study (PLoS Medicine) Cacioppo, J. T. & Cacioppo, S. (2014). "Social relationships and health: The toxic effects of perceived social isolation." Social and Personality Psychology Compass, 8(2), 58-72. Link to Study (PubMed) Cole, S. W. (2014). "Human social genomics." PLoS Genetics (Cited as PLoS Biology in text, corrected to Genetics based on search), 10(8), e1004601. Link to Study (PLoS Genetics) Group Rituals, Synchrony & Physiology Tarr, B., Launay, J., & Dunbar, R. (2014). "Music and social bonding: 'self-other' merging and neurohormonal effects." Frontiers in Psychology, 5, 1096. Link to Study (Frontiers) Konvalinka, I. et al. (2011). "Synchronized arousal between performers and related spectators in a fire-walking ritual." Proceedings of the National Academy of Sciences, 108(20), 8514–8519. Link to Study (PNAS) Digital Communities & Social Learning Lave, J. & Wenger, E. (1991). Situated Learning: Legitimate Peripheral Participation. Cambridge University Press. Link to Book Information (Cambridge University Press) Wenger, E. (1998). Communities of Practice: Learning, Meaning, and Identity. Cambridge University Press. Link to Book Information (Cambridge University Press)