POPULARITY
7 episodes with apoe4
7 episodes with apoe4
6 episodes with apoe4
6 episodes with apoe4
6 episodes with apoe4
6 episodes with apoe4
4 episodes with apoe4
3 episodes with apoe4
3 episodes with apoe4
In this episode, Dr. Jockers explores the shocking truth about saturated fat—how it can actually lower inflammation, protect your cells, and even reduce your risk of stroke. You'll learn how the right fats support hormone signaling, boost energy, and promote healthy aging. You'll discover the brain-enhancing power of medium-chain fats that fuel memory, mood, and cognition. These unique fats also spark mitochondrial growth and strengthen immune defenses in ways most people never expect. But not everyone benefits the same. Dr. Jockers explains who should be cautious with saturated fat, how genetics like the APOE4 gene and sluggish bile flow come into play, and what it means for your long-term health. In This Episode: 00:00 Introduction to Saturated Fats 03:30 Health Benefits of Saturated Fats 04:07 Understanding Oxidation and Inflammation 06:26 Saturated Fats and Brain Health 07:30 Saturated Fats and Immune System 08:31 Saturated Fats and Hormone Function 11:33 When Saturated Fats Can Be Problematic 13:18 Improving Bile Flow and Liver Health 14:56 Genetic Considerations: APOE4 Gene 16:48 Best Sources of Saturated Fats 20:07 Conclusion and Final Thoughts Are swollen legs or ankles slowing you down? Discover the power of Lymph System Support by Pure Health Research. Crafted with natural ingredients like dandelion extract, burdock root, and bromelain, this formula unclogs your lymphatic system, reducing swelling and supporting a healthy inflammatory response. As a special offer, try Lymph System Support risk-free today and receive a complimentary bottle of curcumin extract. Visit GetLymphHelp.com/jockers to claim yours now. Say hello to renewed vitality and goodbye to discomfort! Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com/DRJ. “Chronic disease starts with oxidation—saturated fat helps shut it down.” ~ Dr. Jockers Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio Resources: GetLymphHelp.com/jockers Visit https://renewyourhair.com/drj Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
In part one of this two part series, Dr. Stacey Clardy and Casey R. Vanderlip discuss what neurologists need to know about how APOE4 and amyloid interact to impact cognitive function. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000213853
Dr. Stacey Clardy talks with Casey R. Vanderlip about whether the accelerated decline in episodic memory among APOE4 carriers is due to increased Aβ deposition or heightened susceptibility to Aβ-related effects. Read the related article in Neurology®. Disclosures can be found at Neurology.org.
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
Are there ways to detect the presence of Alzheimer's dementia early, so preventive measures can be taken to reverse or slow its progression? In this special episode of Nerds' Nook, we join Dr. Krista Kostroman, Chief Science Officer of The DNA Company, in diving into the study of how APOE4 plays a factor to late onset dementia, and ways on how to prevent it. We know that certain diet and lifestyle changes can slow or even reverse dementia symptomology. Therefore, looking at the brains of those suffering with late-onset depression might give them a seven-year head start by making those changes before symptoms even appear. #Alzheimersdementia #dementia #lateonsetdepression #dementiatreatment Medical Disclaimer: The information provided in this communication is for general informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read here. If you think you may have a medical emergency, call your doctor or 911 immediately.
Literature Review 1) An exciting phase three trial with the CETP inhibitor Obicetrapib has shown serious promise for ASCVD and Alzheimer's Disease (AD). "In BROADWAY, a pre-specified AD sub-study was designed to assess plasma AD biomarkers in patients enrolled in the BROADWAY trial and evaluated the effects of longer duration of therapy (12 months) with a prespecified population of ApoE3/4 or 4/4 carriers. The sub-study included 1727 patients, including 367 ApoE4 carriers. The primary outcome measure was p-tau217 absolute and percent change over 12 months. Additional outcome measures included neurofilament light chain (“NFL”), glial fibrillary acidic protein (“GFAP”), p-tau181, and Aβ42/40 ratio absolute and percent change over 12 months. NewAmsterdam observed statistically significant lower absolute changes in p-tau217 compared to placebo over 12 months in both the full ITT population (p
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Donanemab's New Dosing Regimen: Lowering ARIA Risk in Alzheimer's Care" John Sims, MD, head of medical development for donanemab at Eli Lilly and Company, joins NeurologyLive to discuss the recently updated label for donanemab (Kisulna), an anti-amyloid Alzheimer disease (AD) therapy. Sims breaks down the key safety data from the TRAILBLAZER-ALZ-6 study (NCT05738486) that led to a newly approved titration-based dosing regimen aimed at minimizing ARIA risk. He outlines considerations for clinicians treating patients with early-stage AD, including genotype-based stratification, ARIA severity patterns, and implications for prescribing and patient counseling. Furthermore, Sims also shares takeaways about donanemab's clinical impact and how the results may shape the future of anti-amyloid therapy development and AD care. Looking for more dementia and Alzheimer disease discussion? Check out the NeurologyLive® Dementia and Alzheimer disease clinical focus page. Episode Breakdown: 1:00 – Overview of the new donanemab dosing regimen and its goal to reduce ARIA risk 2:30 – Rationale behind the four different dosing strategies tested in Trailblazer-ALZ-6 6:00 – What clinicians should know about patient risk and genotype testing 8:00 – Neurology News Minute 10:10 – Clinical implications of the updated label, including risk-benefit conversations 13:45 – Surprising results from the trial, particularly for APOE4 homozygous patients The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Orexin-Targeting Agent TAK-861 Meets All End Points in Phase 3 FirstLight and RadiantLight Studies FDA Shuts Down Sarepta's Distribution of Gene Therapy Elevidys Following Patient Deaths AD109 Meets End Points in Phase 3 LunAIRo Trial, Eyeing FDA Submission for Obstructive Sleep Apnea Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
Rhonda Patrick, Ph.D. (@foundmyfitness) is a biomedical scientist and the founder of FoundMyFitness, a platform dedicated to delivering rigorous, evidence-based insights on improving healthspan and mitigating age-related diseases.Sponsors:Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine and other supplements: https://livemomentous.com/tim (code TIM for up to 35% off)David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim (Buy 4 cartons, get the 5th free.)Monarch Money track, budget, plan, and do more with your money: MonarchMoney.com/Tim (50% off your first year at monarchmoney.com with code TIM)Timestamps:[00:00:00] Start.[00:04:54] Dealing with aging parents and other topics on the table.[00:10:43] How a common multivitamin helps reverse cognitive and memory aging.[00:12:04] The importance of supplementation — especially as we age.[00:13:10] Effectively supplementing with omega-3 fish oil to counter APOE4 and Alzheimer's risks.[00:16:50] The CoQ10 and omega-3 protocol that has helped Rhonda's father manage Parkinson's symptoms for nearly a decade.[00:19:28] Sulforaphane: a potent NRF2 activator with an unexpected benefit for Rhonda's mother's tremors.[00:25:34] How Rhonda convinced her mom to start CrossFit and the power of community-based, senior-focused fitness.[00:26:52] The earlier the intervention, the better the outcomes.[00:32:25] Intermittent fasting vs. extended fasting and my own results.[00:44:31] Does fasting destroy muscle mass? Debunking the catabolism fear and understanding the crucial role of the re-feeding phase.[00:57:24] "Dirty" fasting: what really happens to autophagy and metabolic benefits when you add a splash of cream or MCT oil to your coffee?[01:00:44] VO2 max: the one metric that may predict lifespan more accurately than anything else, and how we work to improve it.[01:12:07] How a two-year exercise program reversed heart aging by 20 years in previously sedentary, middle-aged adults.[01:16:18] Lactate isn't the enemy: how vigorous exercise creates a superfuel that protects and grows the brain.[01:20:30] The optimal sauna protocol (temperature and frequency) for slashing dementia risk by 66%.[01:29:17] If you're human, you'll find a use for curcumin.[01:30:43] Creatine for cognition: moving beyond the gym with a powerful, science-backed tool for focus and combating sleep deprivation.[01:42:41] Still vitamin D deficient despite taking supplements? Here's the critical cofactor you're probably missing.[01:53:52] Shocking sources of microplastics in our daily lives, including chewing gum and teabags.[02:04:10] The uncomfortable truth about "moderate" alcohol consumption, cancer risk, and why the "sick quitter" hypothesis makes most older studies unreliable.[02:17:03] The ups and downs of ketamine and psilocybin on cognition and longevity.[02:24:19] Parting thoughts and where to find more from Rhonda.*Show notes for this episode: https://tim.blog/2025/07/24/dr-rhonda-patrick/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3043: Many traditional diets share key traits like rich sources of fat-soluble vitamins and the absence of processed foods, but Ben Greenfield highlights why your ideal diet depends heavily on your unique genetics. From amylase production to ApoE variants and vitamin A conversion, this piece reveals how ancestral eating patterns and individual gene expression shape the best nutritional approach for your body. Read along with the original article(s) here: https://bengreenfieldlife.com/article/nutrition-articles/how-to-figure-out-what-diet-is-right-for-you/ Quotes to ponder: "The more AMY1 copies you've inherited (and the more of this enzyme you produce as a result), the better your starch-metabolizing capabilities will be." "Depending on what you inherited from your parents, you'll carry a combination of any two ApoE variants: ApoE2, ApoE3, or ApoE4." "Two common mutations on the BCM01 gene, which helps govern the beta-carotene-to-vitamin-A conversion process, make it nearly impossible to get enough vitamin A from the plant kingdom alone." Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3043: Many traditional diets share key traits like rich sources of fat-soluble vitamins and the absence of processed foods, but Ben Greenfield highlights why your ideal diet depends heavily on your unique genetics. From amylase production to ApoE variants and vitamin A conversion, this piece reveals how ancestral eating patterns and individual gene expression shape the best nutritional approach for your body. Read along with the original article(s) here: https://bengreenfieldlife.com/article/nutrition-articles/how-to-figure-out-what-diet-is-right-for-you/ Quotes to ponder: "The more AMY1 copies you've inherited (and the more of this enzyme you produce as a result), the better your starch-metabolizing capabilities will be." "Depending on what you inherited from your parents, you'll carry a combination of any two ApoE variants: ApoE2, ApoE3, or ApoE4." "Two common mutations on the BCM01 gene, which helps govern the beta-carotene-to-vitamin-A conversion process, make it nearly impossible to get enough vitamin A from the plant kingdom alone." Learn more about your ad choices. Visit megaphone.fm/adchoices
“What we decide to put in our mouth each day, what time we decide to go to sleep, who we choose to engage with, how much movement we get, how we manage our stressors, those choices that we make each day that seem really simple, those have the biggest impact on our brain health as we age." - Dr. Heather Sandison When my son Grant suffered his traumatic brain injury, I learned firsthand how devastating cognitive decline can be for an entire family. That's why I was so excited to sit down with Dr. Heather Sandison, a pioneering naturopathic doctor who's literally rewriting the story around Alzheimer's and dementia. While most memory care centers are one-way doors, Heather runs what she calls a "memory recovery program" where the goal is for people to return home—and they're doing it! Through her groundbreaking work applying Dr. Dale Bredesen's protocols, she's seeing 74% of her patients with cognitive impairment actually improve. Her approach to preventing Alzheimer's in midlife women focuses on hope, action, and evidence-based strategies that work. Whether you're carrying APOE4 genes, worried about your family history, or simply want to protect your brain as you age, this conversation is packed with hope and actionable strategies for preventing Alzheimer's in midlife women. From the power of ketogenic nutrition and sleep optimization to addressing hidden infections and hormonal signaling, Heather breaks down the six pillars of brain health that every woman over 40 needs to understand. This isn't about accepting decline—it's about taking control of your cognitive destiny. The six key components of brain health and how to optimize each one for preventing alzheimer's in midlife women Why APOE genetic testing is crucial for women over 40 and how to act on your results How sleep apnea (even in thin women who don't snore) devastates brain health and simple at-home testing options The specific ketogenic approach that helps patients remember their grandchildren's names within 72 hours Hidden infections in your mouth and body that trigger brain inflammation and cognitive decline Why caregivers have 2-6 times higher risk of developing Alzheimer's and how to protect yourself The surprising connection between hormones, exercise, and building new brain connections after menopause Simple lifestyle interventions that work better than any pharmaceutical for preventing cognitive decline Love the Podcast? Here's what to do: Make My Day & Share Your Thoughts! Subscribe to the podcast & leave me a review Text a screenshot to 813-565-2627 Expect a personal reply because your voice is so important to me. Join 50,000+ followers who make this podcast thrive. Want to listen to the show completely ad-free? Go to subscribetojj.com Enjoy the VIP experience for just $4.99/month or $49.99/year (save 17%!) Click “TRY FREE” and start your ad-free journey today! What You'll Learn:Full show notes (including all links mentioned): https://jjvirgin.com/reversingalzheimers Learn more about your ad choices. Visit megaphone.fm/adchoices
Humans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer's-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly evolved 200,000 years ago, may offer some protection. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40700]
Humans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer's-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly evolved 200,000 years ago, may offer some protection. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40700]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Humans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer's-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly evolved 200,000 years ago, may offer some protection. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40700]
Humans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer's-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly evolved 200,000 years ago, may offer some protection. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40700]
Humans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer's-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly evolved 200,000 years ago, may offer some protection. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40700]
Humans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer's-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly evolved 200,000 years ago, may offer some protection. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40700]
For many women, memory changes during perimenopause and menopause can be unsettling. We find ourselves wondering: Is this just brain fog? Is this normal? Or could it be something more serious? In this critical episode, Shelley Craft is joined by Professor Ralph Martins, AO, one of the world's leading Alzheimer's researchers, to help us separate fact from fear and to understand what's really going on in our brains as we age. Dementia is now the leading cause of death for women in Australia, yet so few are talking about it. This conversation is about breaking the silence, reducing fear, and creating a proactive plan to protect our brain health — starting today. Here's a snapshot of our conversation:
Episode #115 is all about diving into the midlife woman's brain—your most vital, complex, and vulnerable organ—and why protecting it matters more than ever. Here's a fact that doesn't get enough attention: two out of three people with Alzheimer's are women. And this isn't just about old age. The seeds of cognitive decline can start as early as your 40s—or even sooner.We'll talk about:• Why women are at greater risk for Alzheimer's and dementia• The brain-hormone connection during menopause and midlife• What you can do now to preserve memory, focus, and cognitive resilience• How genes like APOE4 interact with lifestyle—and what that means• How belly fat, or visceral fat. Affect cognition and brain health• And the power of early, personalized preventionMy guest, Dr. Kellyann Niotis, MD, is the first fellowship-trained preventive neurologist in the world, specializing in risk reduction strategies for neurodegenerative disorders such as Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease. Dr. Niotis led the preventive neurology program within Dr. Peter Attia's medical practice, Early Medical, and managed the country's first Alzheimer's Prevention Clinic at Weill Cornell Medical College/NewYork-Presbyterian Hospital, where she developed research programs for Parkinson's and Lewy Body Dementia prevention. Her work has been published in several medical journals, including Neurology, Nature Mental Health, Frontiers of Aging Neuroscience, Aging and Disease, Movement Disorders, Journal of Alzheimer's Disease, Alzheimer's & Dementia, and Journal of the Prevention of Alzheimer's Diseas,e and has been presented at national and international conferences.She is passionate about the budding medical space of preventive neurology, in particular pertaining to the advocacy of preventive neurology policy changes and making treatment & education more accessible to the masses. She has received numerous honors and awards, and her opinions have been featured in popular media outlets, including CNN.Whether you're looking for tools to sharpen your brain today or you're thinking long-term about protecting yourself and your loved ones, this conversation is full of insight and hope.Medical Disclaimer:By listening to this podcast, you agree not to use this podcast as medical advice or to make any lifestyle changes to treat any medical condition in yourself or others. Consult your own physician for any medical issues that you may be having. This entire disclaimer also applies to any of my guests on my podcast.Learn more about Dr. Niotis:Website: https://drkellyannniotis.com/IG: @drkellyannniotisFB: @drkellyannniotisResources:Lancet Commission Modifiable Risk Factor list:https://www.thelancet.com/infographics-do/dementia-riskStay connected with JFW:Watch on my YouTube channel: https://www.youtube.com/@jillfooswellness/videosFollow me on Instagram: https://www.instagram.com/jillfooswellness/Follow me on Facebook: https://www.facebook.com/jillfooswellnessGrab discounts on my favorite biohacking products: https://www.jillfooswellness.com/health-productsEnjoy 20% savings and free shipping at Fullscript for your favorite supplements by leading brands:https://us.fullscript.com/welcome/jillfooswellnessSubscribe to the JFW newsletter at www.jillfooswellness.com and receive your FREE Guide on How To Increase Your Protein in 5 Easy Steps and your free Protein Powder Recipe Ebook. Schedule your complimentary 30-minute Zoom consultation here:https://calendly.com/jillfooswellness/30-minute-zoom-consultations
Today we have the second installment of our interview with Dr. Michael A. Schmidt, the founder, CEO, and Chief Scientific Officer of Sovaris Aerospace, a company focused on assessments and solutions applied to humans in space and extreme environments on Earth. In today's interview, we talk to Michael about NASA's plans to send humans to Mars and build permanent colonies on the Moon and Mars. We also talk to Michael about his recent book, “Building a Space-Faring Civilization,” which addresses the challenges of civilian spaceflight and the construction of space settlements. In part one of our interview, Episode 182, we talked with Michael about his pioneering work in the field of precision medicine and how he has used it to improve the cognitive and physical performance of astronauts as well as NBA, NFL players and Special Operations forces. In addition to his work with Sovaris, Michael also is a professor of aerospace medicine at the University of Central Florida College of Medicine, one of the few programs in the U.S. that offers a medical residency in aerospace medicine. Show notes: [00:03:00] Dawn picks up our interview from where we left off in part one, discussing the Human Research Program for Civilian Spaceflight. She goes on to mention that Chris Mason at Cornell University has a biobank of 1,500 samples across 22 astronauts and seven missions, and that these samples will lead to deeper insights on the effects of spaceflight on humans. Dawn switches gears to ask Michael about the cognitive and physical challenges of spaceflight over long duration missions. [00:13:03] Following up on the cognitive challenges of long duration spaceflight, Ken mentions that the hippocampus, the primary memory center of the brain, has a relatively low radiation threshold compared to other tissues in the brain. Ken asks Michael to touch on the vulnerability of specialized brain tissues to radiation, particularly in the context of a long duration spaceflight to Mars. [00:21:53] Ken mentions that it is understood that the APOE4/4 genotype is associated with impaired cognitive performance under certain circumstances and an elevated risk of dementia. While it is currently unknown whether APOE4/4 has any correlation of increased risk associated with cognitive impact resultant from environmental exposure due to spaceflight, Ken highlights the concern with sending APOE4/4-positive astronauts on long duration spaceflights without knowing the risks. [00:29:26] Ken notes the worsened cognitive impacts resultant from medical radiation, and while therapeutic radiation is different than radiation experienced by astronauts, these results give some indication of the effects astronauts might experience. [00:33:27] Dawn mentions that we recently had planetary scientist and director of NASA's Haughton-Mars project, Pascal Lee, on the podcast, who explained his view that since there are so many engineering and biological challenges with going to Mars, we should take a more measured approach to a Mars mission, perhaps even beginning with a roundtrip to Mars rather than landing on our first visit. Dawn asks Michael what his thoughts are on this approach. [00:37:29] Ken shifts the discussion to the subject of one of Mars' moons, Phobos, and its potential role in a Mars mission. [00:40:30] Dawn pivots to talk about Michael's Book “Building a Space-Faring Civilization: Advancing the Renaissance of Science, Medicine and Human Performance in Civilian Spaceflight.” Dawn asks Michael to talk about the chapter concerning the question of space radiation from the standpoint of precision medicine. [00:55:12] Dawn asks Michael to talk about the lack of appreciation people have for the fact that a Mars mission would be the most dangerous thing we've ever done. [00:59:06] Ken mentions that Michael has worked with a lot of organizations, including Space X, which has a program, the Space X Mars Colonization Program,
In this episode, you'll learn the 10 most important things to know about APOE4, including its connection to Alzheimer's disease, heart disease, and stroke. Dr. Robert Todd Hurst, MD, FACC, FASE shares proven prevention strategies, lifestyle interventions, and cutting-edge technology to help you take control of your cognitive and cardiovascular future. Key Time Stamps: 00:30 – What APOE4 is and what you will learn here today 01:15 – What does APOE4 mean, Alzheimer's and heart disease risks 02:05 – How dementia risk is growing and how genetics play a role 02:30 – How do you get APOE4 carrier and should you be screened 02:55 – Dementia may be preventable, what the science says 03:55 – The FINGER Trial and how lifestyle changes can improve brain function 04:30 – What's coming next in dementia prevention research 05:18 – A 15-minute cognitive assessment using eye-tracking technology 08:17 – APOE4 and your risk for heart disease and stroke 08:40 – Why waiting for symptoms is no longer an option 09:25 – What's included in the Cognitive Enhancement Program at HealthspanMD 10:35 – Why a team of experts is the path we take at HealthspanMD 12:25 – Why this is not just a checkup, but a strategy for long-term health 13:55 – How to take the first step toward protecting your future This information is for educational purposes only and is not medical advice. Don't make any decisions about your medical treatment without first talking to your doctor. Connect with HealthspanMD: https://www.linkedin.com/company/healthspanmd/ https://www.facebook.com/healthspanmd https://www.instagram.com/healthspanmd/ https://quiz.healthspanmd.com/
Get ready for another insightful Q&A episode featuring your questions! Curious about hormone health and its impact on your well-being? Ever wondered why testosterone cream might cause pesky side effects like acne or hair growth? We discuss potential solutions and alternatives to consider. Struggling with weight gain or stubborn weight loss during menopause? Discover how hormone fluctuations might be playing a role and what steps you can take to regain control. We also delve into the nuances of estradiol therapy post-hysterectomy and the vital importance of monitoring your hormone levels for overall health. Concerned about hormone therapy's role in Alzheimer's risk management, especially if you have the APOE4 gene? We explore personalized strategies that combine diet, exercise, and hormone adjustments. Don't miss out on understanding how accurate hormone testing can enhance your health journey! In this episode, we uncover: How to manage common testosterone cream side effects like acne and hair growth. Why weight gain during menopause might be linked to hormone fluctuations. How estradiol and progesterone creams can alleviate menopause symptoms. Why individualized hormone strategies are crucial for Alzheimer's risk management. How different hormone testing methods provide insights into your health. Unlock valuable knowledge about hormone health by checking out this episode now. Whether you're navigating menopause or curious about HRT, there's something here for everyone! Sponsors Use coupon code HORMONE for 20% off your order. Try the NEW Lemonade LMNT!! Order your LMNT electrolytes today and get a FREE 8 pack of samples! Plus try it risk free, they have a no-questions-asked refund policy – you don't even have to send it back! Timeline is offering 20% off your first order of Mitopure. Go to timeline.com/HORMONE20 and use coupon HORMONE20 and get 20% off your order. Episode Mentions Urine Metabolite Testing for Hormones & What it Tells You, Who It is for & Why It is The Gold Standard of Testing with Karen Martel & Cohost Dr. Amie Hornaman Everything You Need to Know About Hormone Testing Are you in peri or post menopause and looking to optimize your hormones and health? At Hormone Solutions, we offer telemedicine services and can prescribe in every U.S. state, as well as in British Columbia, Alberta, and Ontario in Canada. Visit karenmartel.com to explore our comprehensive programs: Bioidentical Hormone Replacement Therapy Individualized Weight Loss Programs Peptide Therapy for weight loss Interested in our NEW Peptide Weight Loss Program? Join today and get all the details here. Join our Women's Peri and Post Menopause Group Coaching Program, OnTrack, TODAY! To our nursing audience members, our podcasts qualify for nursing CE @ RNegade.pro. Provide # CEP17654. Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert Karen's Facebook Karen's Instagram
In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge sits down with neurologist and bestselling author Dr. Dale Bredesen to challenge everything we think we know about brain aging. Dr. Bredesen shares why age-related cognitive decline is not just treatable but in many cases preventable—and even reversible. Drawing on decades of lab research and clinical success, he outlines the root causes of cognitive decline and introduces the listener to the "cognoscopy," a powerful tool for early detection. With practical, science-backed insights on inflammation, insulin resistance, environmental toxins, and the emerging brain microbiome, this is a masterclass in 21st-century brain health. You'll here them discuss: - Why cognitive decline is often preventable—and sometimes reversible - The three key drivers of cognitive decline: inflammation, energy deficit, and toxicity - How to use the "cognoscopy" to catch signs of dementia early - The role of the brain's microbiome and oral health in neurodegeneration - Why mold, metals, and mycotoxins are underestimated threats - New blood biomarkers like pTau217, GFAP, and NFL - Supplements that support brain health, including magnesium threonate and omega-3s - How to tailor treatment using functional lab testing and wearables - Stories of patient recovery—and what makes the difference Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide
Is your health routine actually making you healthier, or just making you more anxious?In this episode of The Augmented Life, Michael J.J. Tiffany sits down with biohacker and longevity expert Nathalie Niddam to unpack the line between meaningful health optimization and counterproductive obsession.They dive deep into practical longevity, the role of hormones, light, genetics, wearables, and even peptides, starting with what really matters: How you feel, how you live, and whether you've nailed the basics.Nathalie offers a grounded, systems-thinking approach to health: Test intelligently, live in sync with light and circadian rhythms, move naturally, and don't skip the fundamentals in your rush to "biohack" your way to 100.This conversation is for anyone who's trying to balance data with intuition, modern tech with ancestral wisdom, and optimization with actually enjoying life.—⏱️ Timestamps00:00 – Intro: Optimization vs over-optimization01:00 – Why chasing data can backfire on your wellness04:00 – Foundational health vs fancy interventions06:30 – How to know if you're actually thriving09:00 – Light as a missing piece of the wellness puzzle12:00 – Circadian biology, vitamin D, and UVB tech15:00 – Behavioral change vs jumping to TRT18:00 – The role of strength training in longevity21:00 – Labs that actually matter (and what they tell you)23:00 – Why most people are taking the wrong supplements24:30 – Biological age tests and what to do with the data28:00 – HRV: Overrated, misunderstood, or useful?32:00 – The value of tuning in before you tune your metrics35:00 – Genetics as lifestyle feedback, not destiny39:00 – Living well with APOE4 and other gene variants42:00 – Why the foundations still matter more than any one hack44:00 – Peptides, testing, and when to actually start46:00 – Final advice: Direction > perfection
Big shift in Alzheimer's care! We can now predict it years in advance using
Send us a textAnswer a few questions to help me improve this podcast here.We all want to live long and well—but how do we determine how many good years we have ahead?In this episode of Live Long and Well with Dr. Bobby, we explore how to estimate both our total lifespan and the number of years we can expect to remain active and pain-free. Dr. Bobby reflects on personal experiences, emerging science, and time-tested frameworks to help you reframe your health trajectory with clarity and motivation. While we may not find exact answers, the tools and thought experiments shared in this conversation can shape the way we live now—and influence how we plan for the future.We begin with why this topic matters, touching on personal stories of loss, aging milestones, and medical advancements. Then we move into three frameworks: how many years you might live (using tools from actuarial tables to cardiovascular risk calculators), how many of those years might be "good," and the wildcard of unpredictable events.The simplest predictor comes from actuarial life tables, which estimate life expectancy by age and sex. A 55-year-old man today might expect to live to 79; a woman to 82. More advanced tools include the Framingham Risk Score, which factors in cholesterol, blood pressure, smoking status, and diabetes to estimate 10-year cardiovascular risk. Research suggests that sharing these risk scores can lead to behavior changes, as shown in this meta-analysis of 28 studies and preliminary evidence of outcome improvements.On the genetics side, polygenic risk scores offer a glimpse into inherited risks, though they remain research tools for now (Nature study). More accessible are tests for specific genes like APOE4, which increases the risk of dementia (PubMed).Beyond numbers, simple physical tests can offer insight. The Brazilian sit-stand test links mobility with mortality risk: fewer than 8 points doubles your six-year mortality risk. Grip strength, too, is a strong predictor of all-cause mortality across 17 countries (PubMed).While biologic clocks based on DNA methylation are generating buzz, their utility remains limited due to variability between samples and testing methods (Nature Communications).When it comes to estimating “good” years—those lived free from major pain or disability—the data are sparse. Some disease-specific tools (e.g., for MS or dementia progression) exist, but there's no universal actuarial equivalent. However, we know muscle mass and aerobic capacity decline predictably with age—1–2% muscle loss per year and a 10% drop in aerobic fitness per decade (OUP Journal). Predicting your future function can begin with assessing how far you can walk, whether stairs leave you breathless, or how your weight and strength compare to a decade ago.Finally, we can't forget unpredictable events: the odds of a serious fall increase significantly after 65, and vision or hearing loss multiplies that risk (NCOA). Building physical resilience now can reduce these odds—see
You might not realize just how much your oral health is tied to your heart and overall wellness—but it's a connection worth knowing about. I caught up again with my amazing colleague, Dr. Ellie Campbell, and we got into why regular lab tests sometimes miss the early signs of things like heart disease, stroke, and even dementia. We talked about why your dentist could actually be one of the most important people on your health team, plus some sneaky risks that only advanced testing can catch. Dr. Ellie has been in family medicine for over 25 years, mixing integrative and functional approaches to help people truly understand their health. She shared some eye-opening stuff about how sleep apnea can mess with your blood sugar, why fasting blood sugar numbers matter more than you think, and how your genes could be playing a bigger role than you realize. She also gave some solid advice on how to speak up for yourself in a medical system that doesn't always connect these dots. If you're someone who wants to take better care of yourself and catch problems before they sneak up, this episode is packed with tips that really hit home. And by the way, just to sweeten things up—my new Mighty Maca Mango is out now, perfect for spring and summer. It's a delicious twist on Mighty Maca that you can toss in sparkling water or make into popsicles. Check it out anytime at dranna.com—it's a little treat with big benefits. Key Timestamps: [00:00:00] Introduction. [00:04:54] How to know if you have cardiovascular disease. [00:10:09] Corrupted LDL cholesterol explained. [00:11:32] Oxidative stress and antioxidants. [00:15:54] Gender differences in blood sugar. [00:20:20] Increased mortality with very low blood sugar. [00:24:21] Continuous glucose monitors' impact. [00:28:56] LDL cholesterol management post-heart attack. [00:32:03] Markers of oxidative stress. [00:36:43] ApoE4 gene and health risks. [00:39:57] 2 recommended radiology tests for patients over 40. [00:46:13] Atherosclerosis awareness and prevention. Memorable Quotes: "People with the highest cholesterol live the longest. You heard that right." [00:10:30] – Dr. Ellie Campbell "I believe that we saved that patient from a heart attack or a stroke by identifying leading indicators in blood that told me she had a dental problem that took three dentists to find." [00:34:21] – Dr. Ellie Campbell Links Mentioned: Mighty Maca Mango: https://drannacabeca.com/products/mighty-maca The Blood Pressure Blueprint: https://bpblueprint.com/ Connect with Dr. Ellie Campbell: Website: https://www.campbellfamilymedicine.com/ Instagram: https://www.instagram.com/ellie.cfm/ Connect with Dr. Anna Cabeca: Website: https://drannacabeca.com/pages/show Instagram: https://www.instagram.com/thegirlfrienddoctor/ YouTube: https://www.youtube.com/@thegirlfrienddoctor TikTok: https://www.tiktok.com/@drannacabeca Produced by Evolved Podcasting: www.evolvedpodcasting.com
Discover my premium podcast, The Aliquot Vitamin D is far more than just a vitamin—it's a potent steroid hormone regulating nearly 5% of our genome. Yet, remarkably, up to 70% of Americans aren't getting enough, placing them at increased risk for dementia and Alzheimer's disease. In this episode, I explore compelling new evidence from a study involving over 12,000 participants, demonstrating that vitamin D supplementation can reduce dementia risk by an impressive 40%, protecting even adults with genetic Alzheimer's risk (ApoE4 carriers). Timestamps: (00:00) Can vitamin D supplements reduce dementia risk? (00:46) How common is vitamin D deficiency? (03:31) What studies reveal about genes, vitamin D, and dementia (05:44) Does deficiency accelerate brain aging? (06:45) Can vitamin D supplementation enhance cognitive function? (08:15) Dementia risk reduction insights from 12,388 adults (09:58) Why women may benefit most (10:49) Normal vs. impaired cognition—who benefits more from vitamin D? (11:21) Do ApoE4 carriers get dementia protection from vitamin D? (13:00) How mild cognitive impairment affects dementia risk (13:41) Does the form of vitamin D matter? (14:11) What are the optimal vitamin D blood levels? (15:07) What dose corrects deficiency? (15:33) How vitamin D directly supports brain function Watch this episode on YouTube Show notes are available by clicking here The study discussed: Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
How important is one's family history when determining Alzheimer's risk? Returning guests Drs. Jessica Langbaum and Sterling Johnson discuss the latest research on family history and genetic risk factors and share their perspectives on the topic, specifically focusing on the role of the APOE gene as a risk factor. Guests: Sterling Johnson, PhD, leader, Wisconsin Registry for Alzheimer's Prevention (WRAP), associate director, Wisconsin Alzheimer's Disease Research Center, associate director, Wisconsin Alzheimer's Institute, lead principal investigator, ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI), Jean R. Finley Professor of Geriatrics and Dementia, UW School of Medicine and Public Health, and Jessica Langbaum, PhD, senior director of research strategy, Banner Alzheimer's Institute, overseer, Observational Research Program, Clinical Trials Program, Alzheimer's Prevention Initiative, director, Alzheimer's Prevention Registry, director, Arizona Alzheimer's Disease Research Center Show Notes Read Dr. Langbaum's viewpoint, “The Risk of Alzheimer Disease in APOE4 Homozygotes,” on the Journal of American Medical Association (JAMA) website. Read Dr. Johnson's article, “APOE4 homozygosity represents a distinct genetic form of Alzheimer's disease,” on Nature Medicine's website. Read Dr. Chin's opinion piece, “What to do if your family has a history of Alzheimer's,” mentioned at 2:04 on the Wisconsin State Journal's website. Please note there is a paywall to access the article. Read Dr. Tobey Betthauser's paper, “Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts,” mentioned by Dr. Johnson at 16:50, on the National Library of Medicine's website. Learn more about the Banner Alzheimer's Institute on their website. Read about the GeneMatch program from the Alzheimer's Prevention Registry on their website. Learn more about the Arizona Alzheimer's Disease Research Center on their website. Connect with us Find transcripts and more at our website. Email Dementia Matters: dementiamatters@medicine.wisc.edu Follow us on Facebook and Twitter. Subscribe to the Wisconsin Alzheimer's Disease Research Center's e-newsletter. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer's. All donations go toward outreach and production.
If you’re worried about memory loss or have a family history of Alzheimer’s, this episode is a must-listen. Angela sits down with world-renowned neurologist and author Dr. Dale Bredesen to unpack the groundbreaking science behind Alzheimer’s prevention and reversal—even if you carry the APOE4 gene. With over 30 years of research, Dr. Bredesen shares how to optimise your brain health through metabolic flexibility, inflammation control, and personalised interventions. In this powerful and deeply personal episode, Angela also opens up about her own genetic risk and experience caring for her mum with Alzheimer’s. They explore why cognitive decline is not inevitable and how Dr. Bredesen’s new book, The Ageless Brain, is putting the power back into your hands. Whether you're 35 or 75, the steps to preserve your cognition start now—and the tools have never been more accessible. KEY TAKEAWAYS: Alzheimer’s Is Preventable and Reversible: Dr. Bredesen explains how addressing root causes like inflammation, metabolic dysfunction, and toxicity can stop and even reverse cognitive decline. Perimenopause and Brain Fog: Oestrogen loss affects brain energy metabolism, making perimenopausal women more vulnerable to cognitive decline. Your Brain Runs on Supply & Demand: Cognitive health depends on supporting your brain’s high energy needs while reducing inflammatory load and toxic exposure. Check Your Cognitive Biomarkers Early: Blood markers like P-Tau217, GFAP, and A-beta42 can reveal risk decades before symptoms appear. Lifestyle = Medicine: Sleep quality, insulin sensitivity, resistance training, brain stimulation, and even stress reduction all play a critical role. GLP-1s and Alzheimer’s Risk: While popular for weight loss, these drugs may negatively impact cognition in some people—especially APOE4 homozygotes. TIMESTAMPS AND KEY TOPICS:0:00 – Introduction 6:48 – Pathogens, toxins, and the real cause of Alzheimer’s 13:32 – Menopause, oestrogen, and female brain vulnerability 24:05 – Judy’s story: reversing cognitive decline for 13+ years 32:18 – Most common risky behaviours for brain degeneration 42:21 – Best exercises for insulin sensitivity and cognition 51:10 – Supplements that protect brain structure & function 54:22 – How to use The Ageless Brain as a practical guide 58:45 – Final thoughts + where to learn more from Dr. Bredesen VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Get 20% off the Creatine I love at trycreate.co/ANGELA20, and use code ANGELA20 to save 20% on your firsts order. Brain Boost: Try Neuro Regenerate at lvluphealth.com/angela and use code ANGELA15 to save 15% ABOUT THE GUEST Dale Bredesen, M.D. is an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease. He is a graduate of Caltech, and received his MD from Duke University Medical Center. His career has included serving as Chief Resident in Neurology at the University of California, San Francisco, and served as a NIH Postdoctoral Fellow. His faculty position included working at UCSF, UCLA, and the University of California, San Diego. He was the director of the Program on Aging at the Burnham Institute. He was the founding President and CEO of the Buck Institute. He has developed a new therapeutic approach to treating Alzheimer's disease. He is the author of The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline. Dr Dale Bredesen’s latest book: The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime - https://amzn.eu/d/gdrjKQm https://www.apollohealthco.com/ https://www.instagram.com/drdalebredesen/ https://www.facebook.com/drdalebredesen/ ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast. This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/
Language is the invisible prison that keeps us trapped in a medical paradigm designed to manage symptoms rather than restore health. When we adopt words like "diagnosis," "treatment," and "cure," we unwittingly submit to a worldview where health is impossible and disease inevitable.I've spent nearly four decades guiding people back to health by first liberating them from the constraints of medical terminology. The words you use about your body create biochemical realities – changing your language is the first step toward changing your biology. This isn't just philosophical; it's practical physiology.Consider what happens when tissue is damaged by radiation, creating pleural effusions that make breathing difficult. The conventional approach treats this as a "side effect" to be managed, but it's actually a direct consequence of cellular damage from ionizing radiation producing free radicals. The solution isn't more medication but abundant antioxidants to neutralize these reactive species, along with movement, proper sleep timing, and nutritional support to restore normal function.Even conditions like Alzheimer's, which medicine portrays as genetic destiny, are primarily responses to environmental toxicity and nutritional deficiencies. The APOE4 gene doesn't determine your fate; it simply affects how cholesterol is distributed – a process profoundly influenced by diet, dental health, and hormone balance. When patients restore these foundational elements, cognitive function often returns.The gateway to healing begins with recognizing that your body isn't harboring invaders called diseases – it's adapting as best it can to toxic burdens. Cleansing through juicing, biological dentistry, and targeted supplements creates the conditions for recovery, while practices like meditation provide an inner sanctuary from whichSend us a text Join Dr. Lodi's Inner Circle membership and unlock exclusive access to webinars, healthy recipes, e-books, educational videos, live Zoom Q&A sessions with Dr. Lodi, plus fresh content every month. Elevate your healing journey today by visiting drlodi.com and use the coupon code podcast (all lowercase: P-O-D-C-A-S-T) for 30% off your first month on any membership option. Support the showThis episode features answers to health and cancer-related questions from Dr. Lodi's social media livestream on Jan. 19th, 2025Join Dr. Lodi's FREE Q&A livestreams every Sunday on Facebook, Instagram, and Tiktok (@drthomaslodi) and listen to the replays here.Submit your question for next Sunday's Q&A Livestream here:https://drlodi.com/live/Facebookhttps://www.facebook.com/DrThomasLodi/Instagramhttps://www.instagram.com/drthomaslodi/ Join Dr. Lodi's Inner Circle membership and unlock exclusive access to webinars, healthy recipes, e-books, educational videos, live Zoom Q&A sessions with Dr. Lodi, plus fresh content every month. Elevate your healing journey today by visiting drlodi.com and use the coupon code podcast (all lowercase: P-O-D-C-A-S-T) for 30% off your first month on any membership option. Learn to Thrive with ADHD Podcast Welcome to the Learn to Thrive with ADHD Podcast. This is the show for you if you're... Listen on: Apple Podcasts Spotify Join Dr. Lodi's informative FREE Livestreams...
Key Takeaways: Nikki Schultek, Executive Director of the Alzheimer Pathobiome Initiative, shares groundbreaking research at the International Lyme and Associated Diseases Society (ILADS) Conference. The initiative is investigating the connection between infections—such as Lyme disease, Epstein-Barr virus, and long COVID—and neurodegenerative diseases like Alzheimer's. ILADS provides a crucial platform for researchers to collaborate, break down silos, and drive innovation in chronic illness research. A recent symposium brought together experts across multiple disciplines to explore microbial drivers of brain diseases. The team has submitted a major grant proposal to advance research on infectious and microbiome influences on Alzheimer's. A newly published review article in the Journal of Infectious Diseases highlights key findings and perspectives from the initiative. Insights into host vulnerabilities, including the role of the ApoE4 gene, are shaping a deeper understanding of individual susceptibility to neurodegenerative conditions. The discussion underscores systemic healthcare challenges in addressing chronic, complex diseases and the urgent need for research-driven changes in medical practice. Resources & Links: Follow the latest ILADS updates at ILADS.org Learn more about Nikki Schultek and her work: Intracellular Research Group Stay connected with Tick Boot Camp: Website | Instagram | Facebook | YouTube | TikTok | Twitter (X)
Two-thirds of those diagnosed with Alzheimer's disease are women — but why? In this episode, we unpack the neurological, hormonal, and social drivers that uniquely affect women's brain health during the menopausal transition — from estrogen's protective role in the brain to the misunderstood history of hormone replacement therapy. We discuss: • Why women face a higher risk of Alzheimer's than men • How menopause accelerates brain aging (and how it starts earlier than is often expected) • The role of estrogen in brain metabolism and neuroprotection • The real story behind hormone replacement therapy (HRT) • The impact of genes like APOE4 on women's brain health • How lifestyle factors like stress, sleep, and cognitive activity can help reduce the impact of neurological changes onset by menopause ——— Get our free curation of women's brain health resources in our Brain Box: http://thebraindocs.com/brainbox ——— To help us tell this story, we welcome three world-renowned women's health experts to the podcast: DR. LISA MOSCONI: Director of the Women's Brain Initiative, author of ‘The Menopause Brain', and pioneering researcher in brain imaging and hormonal neuroscience. MARIA SHRIVER: Founder of the Women's Alzheimer's Movement, journalist, and relentless advocate for gender equity in brain health research. DR. LISA GENOVA: Neuroscientist and bestselling author of ‘Still Alice', which was adapted into a film starring Julianne Moore, who won the 2015 Best Actress Oscar for her role as Alice Howland. This is... Your Brain On Menopause. ‘Your Brain On' is hosted by neurologists, scientists and public health advocates Ayesha and Dean Sherzai. ‘Your Brain On... Menopause' • SEASON 5 • EPISODE 1 ——— Our free Women's Brain Health Brain Box includes: • Guides on how to speak with healthcare providers about menopause • Delicious brain-healthy Mother's Day brunch recipes • Meaningful gift ideas for the women you love • Inspiring interviews with world-leading women's health experts • And even a chance to check your cognitive health with an insightful, science-backed test Get the Brain Box for free! Here: http://thebraindocs.com/brainbox ——— References: Mosconi, L. (2017). Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. PloS One, 12(10), e0185926. Belloy, M. E. & Alzheimer's Disease Neuroimaging Initiative. (2019). A quarter century of APOE and Alzheimer's disease: Progress to date and the path forward. Neuron, 101(5), 820-838. Rahman, A. (2019). Sex and gender driven modifiers of Alzheimer's: The role for estrogenic control across age, race, medical, and lifestyle risks. Frontiers in Aging Neuroscience, 11, 315. Rocca, W. A. (2012). Hysterectomy, oophorectomy, estrogen, and the risk of dementia. Neurodegenerative Diseases, 10(1-4), 175-178. Scheyer, O. (2018). Female sex and Alzheimer's risk: The menopause connection. Journal of Prevention of Alzheimer's Disease, 5(4), 225-230. Women's Health Initiative Memory Study Investigators. (2003). Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: The Women's Health Initiative Memory Study—a randomized controlled trial. JAMA, 289(20), 2651–2662. Women's Health Initiative Investigators. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA, 288(3), 321-333. Whitmer, R. A. (2005). Midlife cardiovascular risk factors and risk of dementia in late life. Neurology, 64(2), 277-281. Livingston, G. (2024). Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. The Lancet, 404(10452), 572-628. Maki, P. M. (2016). Hormone therapy, dementia, and cognition: The Women's Health Initiative 10 years on. Climacteric, 19(3), 313-315.
Send us a textThis week on The Less Stressed Life, we're talking about reversing cognitive decline and optimizing brain health with Dr. Heather Sandison, author of Reversing Alzheimer's. As a naturopathic doctor and founder of the first memory recovery residential program, Dr. Sandison shares the six root causes of neurodegeneration—and how you can bring the brain back into balance at any age.We're talking about reversing Alzheimer's and neurodegenerative conditions (although it is so much more). From toxins to stress to nutrition, this empowering episode offers real hope and practical tools for preventing and even reversing memory loss. Whether you're supporting a loved one or thinking ahead for your own brain, this is one conversation you don't want to miss.Dr. Sandison's free Keto Diet Guide can be downloaded at: https://www.drheathersandison.com/In that website people can also watch all her content and read her blogKEY TAKEAWAYS:The six root causes of cognitive decline (and how to assess them)How toxins and stress quietly sabotage brain healthWhat your ApoE4 gene does—and doesn't—mean for your futureSigns of early cognitive decline most people missWhat Dr. Sandison's clinical trial revealed about reversing Alzheimer'sABOUT GUEST:Dr. Heather Sandison is the NYT bestselling author of “Reversing Alzheimer's The New Toolkit to Improve Cognition and Protect Brain Health”. She is a renowned naturopathic doctor specializing in neurocognitive medicine and the founder of Solcere Health Clinic, San Diego's premier brain optimization clinic, and Marama, a residential program turning memory care into memory recovery. She has dedicated her career to supporting those suffering with dementia and is the primary author of peer reviewed research published in the Journal of Alzheimer's Disease. She is excited to shatter common misconceptions about Alzheimer's and share what she has learned about keeping your brain sharp at any age.WHERE TO FIND:Website: https://www.drheathersandison.com/Instagram: https://www.instagram.com/dr.heathersandison/WHERE TO FIND CHRISTA:Website: https://www.christabiegler.com/Instagram: @anti.inflammatory.nutritionistPodcast Instagram: @lessstressedlifeYouTube: https://www.youtube.com/@lessstressedlifeSPONSOR:Thanks to Jigsaw Health for sponsoring this episode! Struggling with dry, cracked hands? Try their Alaska Cod Liver Oil for omega-3s + vitamins A & D to support skin and immune health. Use code LESSSTRESSED10 at JigsawHealth.com for 10% off—unlimited use!WORK WITH CHRISTA: I've streamlined my proven method to help you get to the REAL root of eczema and food sensitivities—without the overwhelm. Join the program at christabiegler.com before doors close!
Alzheimer's doesn't just “happen” later in life—it's a slow, silent process that can begin decades before symptoms appear. In this solo episode, we challenge the myth that Alzheimer's is purely genetic, and break down what the science really says about your risk. I explore the role of the APOE4 gene, how it interacts with lifestyle and metabolic health, and why women—especially during and after menopause—may face a unique vulnerability. Most importantly, I introduce three cutting-edge blood tests that can detect the earliest signs of Alzheimer's, long before memory loss sets in. We'll also talk prevention: from blood sugar and insulin resistance to inflammation, hormone balance, and brain energy metabolism—everything you can start doing right now to safeguard your cognitive future. This is more than a conversation about Alzheimer's—it's a roadmap for taking control of your brain health. SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:ZocDoc – Finding a great doctor has never been easier. With ZocDoc, you can browse top-rated physicians, read real patient reviews, and book appointments online - all in one place. Get started here: https://www.zocdoc.com/neuroHone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you're looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuroTroscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.- Get 10% off: https://troscriptions.com/NEURO- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMailTimestamps: 00:00 Top Alzheimer's Myth: Genetics Don't Seal Your Fate01:43 APOE4 Gene Explained: Risk Factors vs. Reality 04:00 Alzheimer's Risk Isn't Just in Your DNA10:50 Top 3 Alzheimer's Biomarkers You Can Test for Today14:47 APOE4 Prevention Plan: Lifestyle Changes That Protect Your Brain The Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman
Did you know that Alzheimer's is mostly preventable and sometimes reversible? Today we'll talk about what we used to think Alzheimer's is, what it really is, what you can do to lower your chances of getting it, and when you need to start. You have more control over your future health outcomes than you're led to believe. Even having 2 copies of the APoE4 gene isn't a match for how you choose to live your life now.Book: The End of Alzheimer'ssend me a message: healthcouragecollective@gmail.comcome get some free stuff from my website: www.healthcouragecollective.com /free resources
El Alzheimer no es un simple efecto del envejecimiento, sino un proceso que comienza décadas antes de los primeros síntomas. En este episodio desvelamos los mecanismos del "ladrón silencioso" de la memoria: el papel del amyloide y el tau, los factores genéticos como el APOE4, y lo más importante, las 14 claves científicamente probadas para reducir hasta un 45% el riesgo de desarrollar demencia. Desde la importancia de cuidar nuestras encías hasta cómo la música y la lectura crean "reserva cognitiva", ofrecemos un mapa completo para enfrentarnos al fantasma que nos acecha a todos. Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals
For decades, we've been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that's only half the story? Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of genetic optimization—how understanding your DNA can unlock longer life, better brain function, and even protection from chronic disease. Forget the old-school genetic reports that left you with useless percentages. The new frontier of precision genomics goes beyond risk factors to actionable insights, showing you exactly how to turn on your body's most powerful longevity genes and turn off the pathways driving inflammation, cognitive decline, and disease. What You'll Learn in This Episode: • Why genetics alone don't determine your future—and how to use epigenetics to control your health • The truth about MTHFR, APOE4, and other “bad” genes—are they actually harming you? • How genetic reports can predict and eliminate brain fog, fatigue, and pain • The hidden genetic reasons behind ADHD, depression, and anxiety—and how to fix them • Why some people age faster—and the one longevity gene that determines your biological age • Cutting-edge breakthroughs in DNA-based biohacking—is it possible to edit your genes for peak performance? This is the future of personalized medicine. By understanding your own genetic blueprint, you can stop guessing and start making the precise changes that will optimize your energy, brainpower, and lifespan! ** Visit IntellxxDNA at https://intellxxdna.com/asprey/ When you go to the website to find a clinician please select “human upgrade/longevity” as the type of consult to get specialized biohacking clinicians! ** SPONSORS -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • IntellxxDNA Website: https://intellxxdna.com/asprey/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 02:00 – The Role of Genetics in Longevity • 03:37 – Gene Variants & Cognitive Health • 05:58 – Epigenetics vs. Genetics • 08:21 – Genomics & Pain Management • 09:26 – Breakthroughs in Genetic Research • 12:33 – The Future of Genomic Medicine • 14:27 – How to Use Genomic Reports • 38:25 – Mitochondria & Longevity • 42:40 – BH4 & Mental Health • 43:42 – Folinic Acid & Brain Function • 44:37 – Genomics & Autism • 46:06 – Personalized Medicine • 56:00 – APOE4 & Alzheimer's Risk • 59:44 – Genetics & Heart Health • 01:04:54 – The Future of Precision Medicine • 01:20:23 – Conclusion & Next Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Story at-a-glance Research found that higher levels of harmful bacteria (Prevotella intermedia) in the mouth are linked to cognitive impairment, while beneficial bacteria (Neisseria and Haemophilus) support better brain function Nitric oxide production by beneficial oral bacteria plays a crucial role in maintaining blood flow to the brain. Nitrate-rich vegetables help boost the population of these healthy bacteria People with the APOE4 gene show a distinct oral microbiome composition. Research shows they have lower levels of Neisseria bacteria and higher amounts of Prevotella, which is associated with increased dementia risk Harmful oral bacteria have the ability to enter the bloodstream and cross the blood-brain barrier, leading to brain inflammation that results in cognitive decline Maintaining oral health through proper diet, regular brushing and flossing, nose breathing, avoiding antibacterial mouthwash and practicing oil pulling are effective strategies against cognitive decline
Alzheimer's disease begins 10 to 30 years before symptoms appear—which means there's a massive window for prevention if you know your risk factors.In this first episode of our four-part series on Alzheimer's prevention, Amy shares why "early is everything" when it comes to protecting your brain health, especially for women navigating midlife. Discover how genetic testing can help predict your risk and why our current healthcare system's approach to Alzheimer's is fundamentally backward.What to Listen For: (10 different points)[00:00:00] Why Amy's personal experience with her mother's Alzheimer's diagnosis in 2016 drove her to research prevention.[00:03:00] The three tiers of prevention in healthcare: primary, secondary, and tertiary—and why Alzheimer's care is fundamentally backwards.[00:07:00] The shocking reality: by the time Alzheimer's symptoms appear, 20% of the hippocampus is already damaged.[00:10:00] How insurance companies limit early testing and what you can do about it.[00:13:00] Understanding preclinical vs. clinical Alzheimer's and why the preclinical phase offers a huge window for intervention.[00:15:00] The three-phase model of Alzheimer's: amyloid plaques, tau tangles, and neuroinflammation—explained.[00:19:00] Why 50 million Americans could already have preclinical Alzheimer's without knowing it.[00:21:00] Genetic factors like APOE4 and their impact on your risk of developing Alzheimer's.[00:24:00] Blood biomarkers for detection: what they reveal and why they're underused.[00:25:00] Why lifestyle changes are just as actionable as new drugs for Alzheimer's prevention.By understanding your genetic risks, you can take meaningful action long before symptoms appear. Tune in to learn more about how to protect your brain health.Don't forget to subscribe for the rest of this series!RESOURCES: Book a FREE Discovery Call with Amy Lang Order Amy's book Thoughts Are Habits Too: Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating. Follow Amy on Instagram @habitwhisperer
In today's episode I am kicking off a 10-part series, "Women's Guide to Alzheimer's Disease," focusing on understanding the complexities of the brain. Delve into the basics of neurons, synaptic connections, and the essential role of vascular health in cognitive function. Discover how lifestyle factors contribute to Alzheimer's and the critical window for intervention. Explore key elements like mitochondrial function and the APOE4 gene's impact. With insights into brain health and disease prevention, this episode lays the groundwork for optimizing cognitive performance and demystifying Alzheimer's.SponsorsZocDoc: https://www.zocdoc.com/neuroMomentous - Use code NEURO to get 20% off your order - https://www.livemomentous.com/neuroTimestamps 0:00 Understanding the Brain's Role in Alzheimer's Disease3:55 Momentous Supplements: Purity, Potency, and Safety Guaranteed5:15 Streamlining Doctor Appointments with Zocdoc6:38 The Brain's Vascular Health and Its Link to Alzheimer's9:27 Understanding Alzheimer's Disease and Brain Health InterventionsThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman
Send us a textCan lifestyle choices truly prevent more than 50% of dementia cases? Join Dr. Douglas Beck and Dr. Dung Trinh as we explore this thought-provoking question and uncover groundbreaking insights. Our discussion dives into the 2024 Lancet study, highlighting 14 modifiable risk factors for dementia and the potential to prevent or delay nearly half of all cases. You'll learn about the crucial role primary care plays in managing Alzheimer's amidst a shortage of neurologists and the importance of addressing lifestyle factors like sleep and obesity. We also weigh the benefits and challenges of FDA-approved monoclonal antibodies, exploring their promise and limitations.In our in-depth conversation, we explore the evolving landscape of Alzheimer's detection and treatment. Hear about the promising potential of biomarkers like P-tau-217 and the role of genetic factors like APOE4. We discuss shifting treatment strategies, moving beyond amyloid-targeted therapies to consider tau proteins and the immune system's involvement. The conversation also shines a light on the flaws in our healthcare system's focus on treatment over prevention, examining the impact of lifestyle industries and Medicare Advantage plans on preventive health measures. Join us for this enlightening discussion that promises to challenge your understanding of Alzheimer's care and prevention. Connect with the Hearing Matters Podcast TeamEmail: hearingmatterspodcast@gmail.com Instagram: @hearing_matters_podcast Twitter: @hearing_mattasFacebook: Hearing Matters Podcast
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