Podcasts about apoe4

If your mom or dad was recently diagnosed with Alzheimer's, you may already feel the weight of caregiving starting to land on your shoulders.But here's the good news: being the primary caregiver does not mean doing it alone.In this episode of Happy & Healthy with Amy, Amy walks you through how to build an Alzheimer's care team early, before caregiving by default becomes an unwanted reality. You'll learn who belongs on the team, what each person holds, and how to ask for help without feeling like you're begging people to care. What to Listen For01:20 — What caregiving in the Alzheimer's space actually means03:00 — How caregiving by default happens 04:45 — Why building a care team is also prevention06:30 — The three professional anchors10:00 — How the neurologist helps you understand the brain-specific picture and future options. 12:15 — Why asking for a social worker may be the one question that changes everything. 15:30 — The one-page care team note that keeps everyone from relying on your memory alone. 18:00 — How to ask family and friends for help so you don't feel like you're beggingBuilding an Alzheimer's care team early is one of the most loving and practical things you can do for your parent, your family, and yourself. Listen to this episode now, then subscribe to Happy & Healthy with Amy and download the free guide, Mom Was Diagnosed with Alzheimer's. Now What?Resources from the EpisodeAlzheimer's Association: https://www.alz.orgAlzheimer's Association 24/7 Helpline: 800-272-3900 ALZConnected: https://www.alzconnected.orgCaregiver Action Network: https://www.caregiveraction.orgAging Life Care Association: https://www.aginglifecare.orgAmy's Free Guide: https://www.amylangcoaching.com/firststepsRecommended Complimentary EpisodesMy Mom Was Diagnosed with Alzheimer's. Am I Next? — This is the natural starting point for listeners who are scared that a parent's diagnosis means their own future is already written. It covers family history, modifiable risk factors, menopause, and the first five brain-health moves Amy recommends. After an Alzheimer's Diagnosis: A Family Checklist — A strong companion episode because it walks families through the first practical questions to ask after diagnosis, including how to move from panic into grounded action. Alzheimer's Prevention: What the Cochrane Review Means — Helpful for listeners trying to make sense of scary headlines, anti-amyloid drugs, and what “clinically meaningful” really means for Alzheimer's prevention. GLP-1s and Alzheimer's Prevention: Hope or Hype? — A good fit for midlife women hearing about GLP-1s, APOE4, and dementia risk and wanting a more grounded way to evaluate the hype. The Menopause–Alzheimer's Link: How to Protect Your Brain Health Now — Recommended for women in perimenopause or menopause who want to understand why this transition matters for cognitive health. RESOURCES:Book a FREE Discovery Call with AmyOrder Amy's book Thoughts Are Habits Too:  Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating.Schedule your Breakthrough Roadmap session with AmyFollow Amy on Instagram @amylangcoaching Follow Amy on Facebook @amylangcoachingSubscribe to Amy's YouTube channel @happyandhealthywithamy

What if one of the most promising frontiers in Alzheimer's research isn't just about what's building up in the brain - but how the brain clears it out? In this episode of Research Renaissance, host Deborah Westphal sits down with Dr. Tirth Patel, a neurologist and physician-scientist at UCLA and 2025 Toffler Scholar, to explore the cutting-edge science of brain clearance, tau protein, and the newly discovered lymphatic vessels surrounding the brain.This is a conversation about curiosity, persistence, and the kind of early-career science that could reshape how we understand and treat dementia.What You'll Learn in This EpisodeWhat tau protein is, why it "gunks up" the brain, and how it differs from amyloid beta in Alzheimer's diseaseThe recently discovered lymphatic vessels in the brain's meninges - and why they matter for clearing toxic proteinsHow sleep deprivation spikes tau and amyloid levels in the blood, and what that means for long-term brain healthThe glymphatic system: the brain's internal waste-clearance highway and its deep connection to sleepWhy aging slows down the brain's lymphatic drainage - and what researchers are doing about itThe genetics of Alzheimer's: the difference between causative mutations (APP, PS1, PS2) and risk factors like APOE4New FDA-approved blood tests and the promise of tau PET scans for better diagnosis and stagingThe latest treatments for Alzheimer's - how they work, their limitations, and what's coming nextWhy failure is one of the most undervalued tools in science - and what's missing in how the field handles negative dataA candid take on AI in biological research: where it helps, where it falls short, and whether it lets scientists failAbout Our GuestDr. Tirth Patel is a neurologist and physician-scientist at UCLA, currently working in the lab of Dr. Jason Hinman. His research focuses on how the brain's meningeal lymphatic vessels clear tau protein from the brain to the bloodstream - a question with major implications for Alzheimer's disease and related dementias. Dr. Patel is a 2025 Toffler Scholar, supported by the Karen Toffler Charitable Trust. He is also the co-host of the podcast Recreational Science, where he and his colleague Dr. Lou Yang explore wacky but well-designed scientific studies to illuminate the scientific method.

Most people think breast cancer treatment ends when the tumor is gone. Science says that's where the real damage often begins, and the woman making that argument was diagnosed at 28, lost her mother to ovarian cancer the same year, and turned her own dismissal by the medical system into a specialization that now treats women nobody else will touch. In this episode, I sit down with Dr. Corinne Menn Board Certified OBGYN, breast cancer survivor, and one of the few specialists in the world treating menopause in cancer survivors. We break down why 80% of women diagnosed with breast cancer have no strong family history, why tamoxifen and aromatase inhibitors quietly devastate brain, bone, and sexual health, and why telling a woman with severe vaginal atrophy to use coconut oil is not evidence-based medicine. Dr. Corinne also opens up about her own diagnosis, her premature menopause at 28, the truth about hormone replacement therapy after breast cancer, and the BRCA, ApoE4, and surgical menopause snowball nobody is putting together for patients. This conversation will completely change how you think about breast cancer, menopause, and the women's health crisis hiding in plain sight. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: Why Nobody Is Coming to Save Breast Cancer Survivors 01:05 Karin's Origin Story: Diagnosed at 28, Losing Her Mom, and Premature Menopause 03:06 The 85% Cure Rate Lie: Why Survival Comes at a Brutal Cost 06:13 Breast Cancer Is Not One Disease: Why 80% Have No Family History 08:14 BRCA1, BRCA2, and the Genetic Mutations Most Women Never Get Tested For 13:14 Karin's Own Genetic Test Story and Why 23andMe Is Not Enough 15:07 BRCA1 vs BRCA2: Age of Onset and When to Remove Ovaries 17:30 The Biology of Estrogen: Why Estrogen Does Not Cause Breast Cancer 23:40 Birth Control, Breastfeeding, and the Real Risk Factors 26:17 Alcohol, Inflammation, and the Toxins Driving Cancer Rates 27:46 Tamoxifen Explained: What It Does to Your Brain, Bones, and Body 34:23 Aromatase Inhibitors: Putting Your Estrogen in the Basement 37:15 Where Women Go When No Doctor Will Help Them 41:17 Oophorectomy, Early Menopause, and the 6 to 12% of Women Affected 44:26 Why Black Women Face the Highest Risk and the Least Care 46:20 The ApoE4, BRCA, and Surgical Menopause Snowball 48:02 Coconut Oil Is Not Medicine: The Vaginal Estrogen Truth 50:35 HRT Denial and the Myths Keeping Women From Treatment 51:13 Who Owns the Breast Cancer Survivor After Treatment Ends 54:18 Why the System Fails: Reimbursement, Resources, and Survivorship Gaps 01:00:07 Can You Be on Tamoxifen and Hormone Replacement Therapy? 01:03:26 Three Neurologists, One Tau Test, and the Dementia Dismissal 01:06:26 Positive Stories: Women Who Took Back Their Health and Won 01:09:16 The One Wish: Valuing Ovarian Function Beyond Reproduction _______ Thank you to our sponsors KetoneIQ: https://ketone.com/NEURO for 30% OFF DailyBasis: https://www.dailybasislife.com/NEURO for 50% off first month IQBARS: https://www.eatiqbar.com/ Biologica: https://biologica.com/NEURO Up to 32% off first subscription order Cure Hydration: https://www.curehydration.com/ Use code NEURO gets 20% off Honey Love: https://www.honeylove.com/NEURO Save 20% Off Honeylove #honeylovepod _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this highlight episode, Dr. Robert Todd Hurst, MD, FACC, FASE sits down with neurologist Jeremy Pruzin, MD to unpack one of the most common and most misunderstood topics in brain health: the difference between dementia and Alzheimer's disease. They explore how vascular health, protein buildup like amyloid and tau, and lifestyle factors all intersect to influence cognitive decline. The conversation also dives into the concept of “mixed dementia,” why prevention strategies overlap with heart disease, and what actionable steps can significantly reduce risk, especially for those with genetic predispositions like APOE4. Watch the full podcast episode here: https://youtu.be/5hIKmiPNGjA Dr. Pruzin is a Behavioral Neurologist, Dementia Specialist, Alzheimer's Disease Researcher - specializing in cognitive disorders and dementia. He brings deep clinical insight into how brain pathology develops over time, helping patients understand risk, early symptoms, and the evolving landscape of treatment. His approach emphasizes both cutting-edge science and practical, personalized strategies for prevention and care. Connect With Jeremy Pruzin, MD - Behavioral Neurologist, Dementia Specialist, Alzheimer's Disease Researcher Website: https://pacocommunity.com/ Instagram:  https://www.instagram.com/jeremypruzinmd/ Linkedin: https://www.linkedin.com/in/jeremy-pruzin-82867615/ Key Timestamps 00:00 Introduction to HealthspanMD Heart Longevity Program 00:40 Overview of episode topics: dementia vs Alzheimer's 01:10 Prevention strategies and link to heart health 02:19 APOE4 explained and what it means for risk 03:00 Practical lifestyle changes to lower dementia risk 04:30 Life's Simple 7 and its impact on dementia 05:45 Why heart health and brain health are deeply connected 06:40 Risk-based prevention and treatment strategies 08:00 Medications and emerging therapies for brain health 08:58 Understanding dementia pathology: vascular vs protein causes 09:40 Difference between dementia and Alzheimer's disease 10:30 What is mixed dementia and why it's most common 11:20 Rethinking how dementia is categorized 12:30 APOE4 risk levels and implications 13:20 Final thoughts and how to take action with HealthspanMD Connect with HealthspanMD :

In this powerful episode of the Whole Body Detox Show, host David DeHaas from Living Waters Wellness Center (Living Waters Cleanse) explores the critical connection between diet, brain health, gut function, and chronic disease prevention. Drawing from real-world clinical experience and emerging research, David uncovers how the foods you eat today directly impact your cognitive health, energy levels, and long-term vitality.This episode dives deep into a 15-year Swedish study published in the Journal of the American Medical Association, revealing that individuals who consume higher amounts of unprocessed meat—especially grass-fed beef—may experience slower cognitive decline and a reduced risk of dementia. The discussion highlights the importance of the APOE4 gene, a major genetic factor linked to Alzheimer's disease, and how personalized nutrition strategies can play a key role in protecting brain function.David explains how essential nutrients like vitamin B12, healthy saturated fats, and amino acids found in high-quality animal products support neurotransmitter function, brain cell repair, and overall mental clarity. He also addresses the growing epidemic of brain fog, memory loss, and early cognitive decline—even among younger adults, connecting these issues to poor diet, environmental toxins, and gut dysfunction.In this episode, you'll learn:Why grass-fed, organic beef is superior to grain-fed meat and how it impacts inflammation and brain healthThe hidden dangers of processed foods, refined sugars, seed oils, and high-carbohydrate diets How gut health influences the brain through the gut-brain axis and why detoxification is essential The role of colon cleansing and toxin removal in restoring energy and mental clarity Why assisted living diets may accelerate cognitive decline due to poor nutrition  How antioxidants and prebiotic fibers—especially from vegetables like asparagus—support digestion, immunity, and cellular repair The importance of reducing exposure to pesticides, herbicides, and environmental toxinsDavid also challenges conventional dietary guiSupport the showReady for your healing journey?Visit our website: www.LivingWatersCleanse.com Or give us a call at: (208) 378-9911Stem Cell Activation Patches:www.StemCellPatch.netGet your Supplements and Natural Body Products Here:www.livingwaterscleanse.com/supplementsQI-Shield EMF Devices:Protect your whole home or office with a touric shield from EMF's. 1. QI Shield Covers 16'x16'2. QI Home Covers 50' x 50'3. QI Max Covers 250'x250'Click on link and enter Livingwaters in discount code section during checkoutMagnesium Soaks:Follow us on our socials: Living Waters Wellness CenterBitChute: www.bitchute.com/livingwaterswellnessRumble: www.rumble.com/living...

Brain fog, anxiety, low mood and memory slips are often brushed off as “stress” or “menopause” until life starts shrinking. We sit down with degree-qualified functional nutritionist Jo Greben to challenge that story and unpack a more useful lens: brain health as a bioenergetic problem where mitochondria, inflammation and fuel supply shape how well we think, feel and sleep.Jo shares what pulled her into dementia prevention and cognitive optimisation, including the impact of family history, brain injury, and seeing reversal-focused research that pushes beyond the outdated “nothing can be done” narrative. We talk about why genetics like ApoE4 raise risk but don't write your future, and why a proper assessment has to look at hormones, toxins, gut-brain signalling, oxidative stress, neuroinflammation and the small details that most rushed consults miss.You'll also hear practical prevention strategies you can start early: better sleep hygiene, smarter exercise with strength training, protein needs in perimenopause and menopause, and how to have a better conversation with your GP about tests that matter such as homocysteine, B vitamins, vitamin D and high-sensitivity CRP. We finish with clinician-loved tools that support calm and cognition, including saffron, L-theanine, creatine and nicotinamide riboside (NR), plus a case study where addressing mould exposure helped reverse a frightening cognitive trajectory.If you care about dementia prevention, mental health, cognitive resilience and healthy ageing, hit play, share this with a friend who's been dismissed, and subscribe so you don't miss what's next. If you found it helpful, leave a review and tell us what brain-health question you want answered next.Shownotes and references are available on the Designs for Health websiteRegister as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.auFollow us on SocialsInstagram: DesignsforhealthausFacebook: DesignsforhealthausDISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health

What if your genes are not your destiny, but a set of clues your body has been giving you all along? In this episode, Dr. Taz sits down with Dr. Florence Comite, endocrinologist, clinician scientist, longevity expert, and author of Invincible: Defy Your Genetic Destiny to Live Better, Longer, to explore how biomarkers, genetics, hormones, sleep, metabolism, and family history shape the way we age.In this episode, Dr. Comite explains why longevity is not just about biohacking, supplements, peptides, or the latest wellness trend. Instead, she shares why true healthspan begins with understanding your own body, your own patterns, and your own family story. She explains how changes in blood sugar, fasting insulin, free testosterone, cholesterol risk ratio, sleep quality, muscle, and metabolism can reveal early signs of disease risk long before symptoms fully appear.Dr. Taz and Dr. Comite discuss why “normal” lab ranges are not always the same as optimal health, why some people begin showing signs of metabolic disease decades earlier than expected, and how family history can act as a powerful roadmap for prevention. They also explore how genetics, lifestyle, hormones, wearables, continuous glucose monitoring, sleep, movement, protein, and personalized medicine may help people change the trajectory of their future health.If you're listening to this and thinking, “I know something is off in my body, but I don't know where to start,” join the Circle here:

If your mom or dad was just diagnosed with Alzheimer's, you're probably wondering: am I next?Watching a parent receive this diagnosis can make every forgotten word, every misplaced key, every moment of brain fog feel suddenly loaded with meaning.In this episode, Amy answers the question directly — with science, with compassion, and with her own deeply personal experience of watching two generations of her family navigate Alzheimer's.What You'll LearnWhat family history actually means for your Alzheimer's risk (and why genes are not destiny)Why most cases of Alzheimer's involve far more than genetics — and what that means for youWhat the Lancet Commission's July 2024 report found about modifiable risk factors (the number will surprise you)Why the menopause transition is one of the most important windows for protecting your brainWhy menopause brain fog is not the same as dementia — and what it is telling youThe first 5 brain-health moves Amy would make if she were starting from scratch todayWhat to Listen For00:00 — Why a parent's Alzheimer's diagnosis can make normal forgetfulness feel terrifying. 01:00 — The message Amy wants you to hear first: family history is not destiny. 02:30 — Amy's personal story of her mother's diagnosis and the moment that changed everything. 06:30 — What family history actually means for Alzheimer's risk. 08:00 — Why late-onset Alzheimer's is influenced by more than genetics. 09:30 — The Lancet Commission's 14 modifiable dementia risk factors and why that number matters. 11:00 — APOE4, women, and why genes are information — not a foregone conclusion. 13:00 — Why menopause is a brain-body transition, not just a reproductive transition. 17:00 — Why panic research usually creates more anxiety, not more safety. 19:00 — The first five brain health moves: sleep, blood sugar, movement, stress recovery, and connection. 30:44 — The Larry Wall quote Amy uses to remind us that the future is shaped one present-moment choice at a time.Resources mentioned in this episode:Free RESTORED Protocol Guide → amylangcoaching.comYour parent's diagnosis may feel like a glimpse into your future, but it is not a foregone conclusion. Your story does not have to be a repeat of your parent's story.Listen to this episode to learn the first five moves Amy recommends for Alzheimer's prevention, then choose one habit to focus on first. Subscribe to Happy & Healthy with Amy so you don't miss next week's episode.Next episode: How to Advocate for a Parent Newly Diagnosed with Alzheimer'sRESOURCES:Book a FREE Discovery Call with AmyOrder Amy's book Thoughts Are Habits Too:  Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating.Schedule your Breakthrough Roadmap session with AmyFollow Amy on Instagram @amylangcoaching Follow Amy on Facebook @amylangcoachingSubscribe to Amy's YouTube channel @happyandhealthywithamy

If you've been following along, you know Penn recently found out he has two copies of the APOE4 gene - basically the “high risk” genetic lottery for Alzheimer's. And while we thought we were prepared for that news… we weren't. It hit hard. For both of us. But this episode is not about fear. It's about hope.This week we are sitting down (again!) with Dr. Richard Isaacson (the brain behind Penn's prevention plan and one of the leading voices in Alzheimer's prevention) to answer YOUR questions. And wow, did you have questions. We discuss what to actually ask your doctor, what Penn is doing right now, prevention strategies that are showing promise, and how close we are to affordable, at-home Alzheimer's risk testing. Spoiler: closer than you'd expect. But the biggest thing we discuss? Why genes are not your destiny.We also get very real about the emotional side of this, like what it's like to love someone who might face this disease, what caregiving actually looks like, and why doing something now matters so much. If you or someone you love has concerns about Alzheimer's, this show is for you. Because for the first time, this doesn't feel like a ticking time bomb. It feels like something we can actually fight. We love to hear from you! Leave us a message at 323-364-3929 or write the show at podcast@theholdernessfamily.com. You can also watch our podcast on YouTube.Learn more about Alzlabs testingGet free prevention support with Retain Your BrainLearn more about Dr. Richard IsaacsonVisit Our ShopJoin Our NewsletterFind us on SubstackFollow us on InstagramFollow us on TikTokFollow us on FacebookLaugh Lines with Kim & Penn Holderness is an evolution of The Holderness Family Podcast, which began in 2018. Kim and Penn Holderness are award-winning online content creators known for their original music, song parodies, comedy sketches, and weekly podcasts. Their videos have resulted in over three billion views and over nine million followers since 2013. Penn and Kim are also authors of the New York Times Bestselling Books, ADHD Is Awesome: A Guide To (Mostly) Thriving With ADHD and All You Can Be With ADHD. They were also winners on The Amazing Race (Season 33) on CBS. Laugh Lines is hosted and executive produced by Kim Holderness and Penn Holderness, with original music by Penn Holderness. Laugh Lines is also written and produced by Ann Marie Taepke, and edited and produced by Sam Allen. It is hosted by Acast. Thanks for listening! Hosted on Acast. See acast.com/privacy for more information.

Trump pulls his surgeon general pick Dr. Casey Means after GOP resistance led by Senator Bill Cassidy stalls her nomination. Maine Governor Janet Mills drops out of the Democratic Senate primary, clearing the path for progressive candidate Graham Platner to take on Republican Susan Collins. Three members of the same family are indicted on federal charges for allegedly assaulting a Turning Point USA reporter during an anti-ICE protest in Minneapolis. A new study suggests higher consumption of unprocessed meat may reduce Alzheimer's risk for people carrying the APOE4 gene, raising questions about personalized nutrition - researchers behind the study Dr. Sara Garcia-Ptacek and Dr. Jakob Norgren of the Karolinska Institute weigh in.      Pure Talk: Dial #250 and say keyword MEGYN KELLY to switch to Pure Talk and get unlimited data for just $34.99 a month!   Herald Group: Learn more at https://GuardYourCard.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

New-think on diet for ApoE4, a risk factor for Alzheimer's—eat meat! Is a non-invasive blood sugar monitor on the drawing board for the next Apple Watch? True or false—does drinking carbonated water help weight loss? Eating while distracted puts on the pounds; Treating duodenitis; How much whey protein should you consume? Why some people fail to lose weight on GLP-1 drugs.

When Penn Holderness described APOE4 as a “ticking time bomb,” it struck a nerve for a lot of people, especially women in midlife who already feel vulnerable about their brain health.Could a GLP-1 medication protect your brain if you carry the APOE4 gene? Amy unpacks the science in plain English and explains why genes are not destiny, why menopause changes the conversation for women, and what research-backed actions you can start taking right now.What to Listen For[00:00] Why Penn Holderness's APOE4 reveal sparked such a big reaction [02:30] What it actually means to carry one or two copies of the APOE4 gene [05:30] Why APOE4 is a genetic predisposition, not a verdict [08:30] The critical difference between APOE4 and the rare genes that directly cause early-onset Alzheimer's [10:30] Why midlife and postmenopausal women may face a different level of APOE4-related risk [14:00] How fear drives people toward quick-fix solutions and why that matters in Alzheimer's prevention [18:00] What the observational GLP-1 research shows and the big caveat most people miss [22:00] What the EVOKE and EVOKE Plus semaglutide trials found in people with early Alzheimer's symptoms [25:30] What hormone therapy can do for sleep and symptom relief — and what it has not been proven to do for dementia prevention [28:30] Why the FINGER study, U.S. POINTER, and modifiable risk-factor research offer the most hopeful path forward [32:30] The free RESTORED guide, the 8 evidence-based lifestyle factors, and Amy's call to take action without panicIf you've been feeling afraid of your genetic risk, this episode is your reminder that APOE4 is not destiny. Amy explains why the most powerful path forward is still grounded in the basics: sleep, movement, metabolic health, stress management, and consistent daily choices. Listen now, subscribe to the show, and grab Amy's free guide so you can start protecting your brain one step at a time.From The EpisodeDownload the free RESTORED ProtocolBook your Breakthrough Roadmap sessionResearch cited in this episode:1. NIA Alzheimer's Disease Genetics Fact Sheet — APOE4 prevalence and risk breakdown https://www.nia.nih.gov/health/alzheimers-causes-and-risk-factors/alzheimers-disease-genetics-fact-sheet2. Altmann A et al. (2014). Sex modifies the APOE-related risk of developing Alzheimer disease. Annals of Neurology. https://pmc.ncbi.nlm.nih.gov/articles/PMC4117990/3. Stanford Medicine (April 2026). Women get Alzheimer's more often than men: Five things the science tells us. https://med.stanford.edu/news/insights/2026/04/women-alzheimers.html4. Alzheimer's Association (2025). Statement on oral semaglutide phase 3 topline data (EVOKE/EVOKE+ trials). https://www.alz.org/news/2025/alzheimers-assRESOURCES:Book a FREE Discovery Call with AmyOrder Amy's book Thoughts Are Habits Too:  Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating.Schedule your Breakthrough Roadmap session with AmyFollow Amy on Instagram @amylangcoaching Follow Amy on Facebook @amylangcoachingSubscribe to Amy's YouTube channel @happyandhealthywithamy

BrainStorm wants to hear from you! Send us a text.In part one of a series on UsAgainstAlzheimer's Brain Health Journey host Meryl Comer is joined by Nancy Meserve, a lived experience advisor and APOE4 double-carrier, and Catherine Patterson, interim COO of UsAgainstAlzheimer's. Their conversation explores the newly launched Brain Health Journey — a suite of resources designed to help people at elevated Alzheimer's risk, those living with the disease, and their care partners navigate the road from concern to diagnosis.You can find the Brain Health Journey at MyBrainGuide.org.Support the show

Neuroscientist and frequent STEM-Talk guest Dr. Tommy Wood rejoins us today for part two of our interview about Tommy's book that is fresh off the press and now available in bookstores and Amazon, “The Stimulated Mind: Future-Proof Your Brain from Dementia and Stay Sharp at Any Age.” Tommy is an Associate Professor of Pediatrics and Neuroscience at the University of Washington, where his laboratory focuses on brain health across human lifespan. Tommy is a colleague and good friend who also is a Visiting Research Scientist here at IHMC. In part one of our interview with Tommy, episode 193, we discussed his mission to dispel the myth that the brain is doomed to decline with age. Tommy gave us a fascinating history of neuroscience and how researchers go about studying the brain. Tommy also talked about what is holding us back in terms of addressing an ever-increasing burden of cognitive and mental health disorders that we are experiencing not only here in the U.S., but also around the world. Today, Tommy shares science-backed strategies to help people future-proof their brains. We talk about the importance of diet and exercise in terms of brain health as well as the importance of stimulating and challenging our brains throughout our lifespans. Tommy has a bachelor's degree in biochemistry from the University of Cambridge, a medical degree from the University of Oxford, and a Ph.D. in Physiology and Neuroscience from the University of Oslo. Show notes: [00:03:55 Dawn welcomes Tommy back for part two of his interview by asking him about his recent trip to the UK. [00:04:32] Dawn recaps where we left off with Tommy in part one of our interview, explaining that when we last spoke with Tommy about his book, The Stimulated Mind, we focused on dispelling myths about the adult brain, in particular the idea that the adult brain is fixed. [00:05:22] Ken asks Tommy about advice his father offered when Tommy got accepted into the University of Cambridge. [00:08:03] As a follow-up, Dawn asks if it's fair to say that when Tommy first started working with patients, what he learned in textbooks and classrooms didn't necessarily translate perfectly into the real world and that there is no one-size-fits-all fix. [00:11:54] Ken asks Tommy to expand on what he wrote in his book about the fact that while science can give us a framework for understanding the world, we are always only one experiment or one well-phrased question away from having to completely rethink everything. [00:16:44] Dawn launches into talking about what people can do to future-proof their brain, starting with diet. In the Nourish chapter of his book, Tommy seeks to help people see food as an opportunity for nourishment rather than a source of stress since there are so many conflicting messages about diet and healthy foods out there. Dawn asks Tommy if his opinion is that there is no one-size-fits-all diet? [00:22:21] Dawn explains that what we eat has a direct effect on our long-term health and dementia risk, and within the literature a common theme that emerges regarding eating for brain health is maximizing nutrients. Dawn asks Tommy to talk about what this looks like. [00:24:49] Dawn points out that people today are inundated with advice from health influencers in all directions. She asks Tommy to talk about his advice to tune out the noise and instead of chasing whatever supplement or super food that is currently in vogue, simply to focus on filling your diet with whole, nutrient dense foods. [00:29:43] Ken explains that nutrients are sometimes hard to get in the diet, with somewhere between 15 and 25 percent of people in the U.S. and Europe having inadequate intakes of most B vitamins and even higher deficits in iron, magnesium, calcium, and vitamins C and E, with nutrient deficiencies differing by sex. Women on average are lower in B12, iron, iodine, and calcium, while men are typically lower in magnesium, zinc, and various B vitamins. Ken asks Tommy to give an overview of what these nutrients do in the brain that makes them so critical to cognitive function. [00:35:51] Ken follows up on this discussion by moving on to the section in Tommy's book titled “To Supplement or Not to Supplement” where he discusses the evidence of the benefits of targeted supplementation to fill in the nutrient gaps that exist in the diet. Ken asks Tommy to talk about this more in depth and maybe give a framework by which people can think about adding or not adding key nutrients via supplementation. [00:41:21] Given the controversial reputation red meat has, Ken asks Tommy to weigh in on how he thinks people should think about red meat. [00:46:26] Fish as well, Dawn explains, has become controversial, due to microplastics and mercury concerns. However, given the positive effects on cognitive health that fish consumption has, Dawn asks Tommy to talk about the costs and benefits of increasing fish consumption. [00:50:30] Ken asks about the genetic basis for dementia and in particular Alzheimer's, particularly regarding the APOE genotypes and a recent paper that made the claim that homozygous APOE4/4 carriers were essentially guaranteed to develop ALzherimer's, a strong claim that Ken is skeptical of. [00:57:06] Ken switches gears to talk about brain energy consumption, noting that while the brain is only about 2% of total body mass, it consumes roughly 20% of total energy at rest. Ken mentions that we discussed this topic in episode 59 with Steven Cunnane and asks Tommy to touch on the importance of getting enough energy for the brain and the consequences of not. [01:01:43] Dawn mentions that time restricted eating and fasting have become quite popular in recent years, and is a topic we discussed in episodes 7, and 133 with Mark Mattson. Dawn asks Tommy what some key considerations are for fasting and time restricted eating. [01:04:52] Ken contrasts low energy availability with the prevalent issue in today's modern food environment of high energy availability, leading to epidemics of obesity and type 2 diabetes, both of which are associated with lower brain volume and are both also implicated in projections of higher dementia burdens in the coming decades. Ken asks Tommy to talk about this. [01:08:55] Dawn asks if Tommy has any practical recommendations on how people can assess whether they are fueling the needs of their brain properly. [01:10:38] Ken notes that brain health is tied closely to the extent to which we stimulate our brains, especially as we age, a topic which was discussed at length with Dr. Rudy Tanzi in episode 174. Ken goes on to ask Tommy to talk about the importance of stimulating our brains as we age. [01:13:38] Dawn notes that Tommy made the realization that the brain adapting to stimulus is very similar to how muscles adapt to resistance training after meeting Josh Turknet, a neuroscientist who loves the banjo as much as Tommy loves weight training. Dawn asks Tommy to talk about how his and Josh's respective hobbies have more in common than he originally thought. [01:16:11] Ken asks if this analogy between the brain and muscle extends to ‘muscle memory' or the phenomenon that people who were at one time more muscular are able to gain back that muscle mass more quickly than when they first trained. [01:19:11] Ken mentions that Josh Turknet, the author of the book Anyone Can Play Music, and our guest on episode 130, co-authored a paper with Tommy titled, “Demand coupling drives neurodegeneration, a model of age-related cognitive decline and dementia.” Ken asks Tommy to discuss this paper. [01:22:58] Dawn explains that Tommy writes in his book that exercise science and athletic coaching have given us a really good idea of how a specific stimulus effects performance. But when it comes to this kind of measurement tracking for cognitive function, it's less straightforward. Dawn asks Tommy to talk about this. [01:25:22] Ken mentions that there are lots of ways to stimulate the brain, with some being more potent than others, such as learning a language or an instrument. Ken asks Tommy what some other examples are of good cognitive exercises and learning endeavors that can help develop cognitive headroom as we age. [01:29:14] Ken asks Tommy about the fact that retirement is often the point in someone's life where their cognitive abilities are most at risk, and that delaying retirement, or retiring and choosing to reinvent oneself and engage in a new and challenging adventure can help prevent the cognitive risks associated with retirement. [01:32:32] Dawn notes that exercise is also incredibly important for brain health and asks Tommy to talk about his framework that people can use to think about movement and physical activity as a way to support brain health. [01:37:28] Ken asks Tommy about a study out of Norway that found that people who increased their fitness in their 50s and 60s decreased their subsequent risk of dementia. [01:39:52] Dawn asks Tommy to talk about the growing issue of social media causing people to lose their attention span. [01:44:03] Dawn asks Tommy how he sees AI affecting our brains today. [01:49:17] Ken notes that while most STEM-Talk guests who have written a book say that they would prefer to not repeat the experience, Tommy however, is already thinking about his next book. Ken asks if Tommy can share what this next book will be about. [01:51:26] Dawn asks Tommy about his wife Elizabeth, who was our guest on episode 71, and a researcher at the University of Washington. [01:52:52] Dawn wraps up asking Tommy if, since moving from North Carolina to Washington, if he and Elizabeth have had any luck finding good barbecue in Seattle. Links: Tommy Wood bio STEM-Talk episode 47 with Tommy Wood STEM-Talk episode 110 with Tommy Wood STEM-Talk episode 111 with Tommy Wood STEM-Talk episode 128 with Tommy Wood STEM-Talk episode 193 with Tommy Wood, part 1 Learn more about IHMC STEM-Talk homepage Ken Ford bio Ken Ford Wikipedia page Dawn Kernagis bio  

What if you could know 20 YEARS before symptoms appear whether you're heading for Alzheimer's? And what if there was a proven way to reverse early cognitive decline? In this episode, I sit down with my dear friend Dr. Dave Jenkins — the leading Dr. Dale Bredesen Protocol practitioner in the Southern Hemisphere — to unpack the p-Tau 217 blood test revolution and the stunning results from Bredesen's latest randomised controlled trial. Dr. Dave breaks down how a simple finger-prick blood test can now detect the Alzheimer's process with 95% certainty up to TWO DECADES before memory symptoms begin. This isn't diagnosing Alzheimer's — it's diagnosing the process, which means you have 20 years to intervene. We dive into Bredesen's 2024 multi-site RCT showing the ReCODE precision medicine protocol is 6–7x MORE POWERFUL than the best Alzheimer's drug currently available in America (lecanemab) — a drug with devastating side effects including brain bleeds and even death. Dr. Dave shares real clinical insights from his Bali longevity practice including the 30–60 "holes in the roof" driving cognitive decline, cutting-edge peptides (Semax, Selank, Cerebrolysin, Dihexa), bioregulators, and his personal experience with Klotho gene therapy that took his memory scores from the 70th to the 97th percentile in just 6 weeks. This is essential listening for anyone with a family history of Alzheimer's, anyone watching a loved one decline, and anyone who wants to take brain health seriously BEFORE it becomes a crisis. ⏰ CHAPTERS: [to be generated after edit]

This week on The Life Lab, host Brent Franson sits down with Dr. Marilyn Albert, a leading Alzheimer's researcher at Johns Hopkins, to unpack what we actually know about Alzheimer's prevention. From the early buildup of amyloid and tau in midlife to the nuanced role of genetics like ApoE4, Dr. Albert speaks to biomarkers, blood tests, and the growing world of experimental longevity hacks. The conversation explores the science behind sleep, diet, exercise, and vascular health, while diving deep into how staying mentally and socially engaged may delay symptoms even when pathology is present. She's a terrific guest and a great resource. Hope you enjoy.

If you carry the ApoE4 gene, you've likely been told your risk for Alzheimer's disease is significantly higher. But what does that really mean, and how much control do you actually have?In this video, Dr. Bret Scher breaks down the science behind ApoE4, one of the strongest genetic risk factors for Alzheimer's disease, and explains why increased risk does not mean a predetermined outcome.You'll learn how ApoE4 may influence brain health through inflammation, lipid metabolism, and energy use, and why lifestyle and environment play a critical role in shaping these pathways.This video also explores:Why ApoE4 does not guarantee Alzheimer's diseaseWhat research shows about traditional populations with low dementia ratesHow metabolic health, diet, and lifestyle may influence brain agingNew research challenging common assumptions about meat, fat, and dementia riskThe role of key nutrients like B12, iron, and amino acids in brain functionDr. Scher also reviews recent observational studies suggesting that higher meat consumption may be associated with lower dementia risk in ApoE4 carriers, challenging long-standing dietary narratives.The takeaway: your genes are one piece of the puzzle. Your daily choices, environment, and metabolic health may play a powerful role in shaping long-term brain outcomes.

Send us Fan MailA 15-year follow-up study out of Sweden forces an uncomfortable question: what if unprocessed red meat isn't a brain-health villain at all, and the real risk sits upstream in metabolic dysfunction and refined carbs? Mark Pettis and John Bagnulo dig into the data on red meat consumption, cognitive decline, and dementia risk, with a special focus on the highest-concern group: people with the APOE4 genotype. If you've ever seen a genetic test result and felt like Alzheimer's disease was inevitable, we want to replace that fear with clarity and actionable context.We break down what the research actually shows, including the dose-response signal and the critical distinction between minimally processed red meat versus processed meat. Then we explore why “what meat replaces” matters: when red meat displaces grains, cereals, and other high carbohydrate density foods, the apparent protection becomes even stronger. From there, we connect the dots to the mechanisms we think deserve more attention in both neurology and cardiometabolic care: insulin resistance in the brain, neuroinflammation, microvascular damage, mitochondrial energy shortfalls, and why plaques may be more response than root cause.To round out the picture, we bring in parallel findings on full-fat dairy and eggs. We talk about the potential role of odd-chain saturated fatty acids, choline, and the broader “food matrix” idea that supplements rarely replicate. Finally, we share a practical set of brain-supportive foods plus a clear list of foods that should give you pause, especially flour-heavy sweets and oxidized shelf-stable animal products.If this challenged your assumptions about saturated fat, cholesterol, and dementia prevention, subscribe, share this with a friend, and leave a review so more people can find it. What's the one food swap you're willing to try for the next four weeks?For video, slides and open source research papers: www.thehealthedgepodcast.com

This week, Penn and I share some real-life updates from our house. I was recently diagnosed with ADHD at 50, which turns out… there were signs. I'm learning what that actually means for my brain, my emotions, and honestly, my entire life up to this point. (Something called “doom piles” should have honestly exposed my ADHD years ago.)Penn also shares an update on his journey to protect his brain health from Alzheimer's. We talk about what he's trying, what we're learning, and how we're thinking about the future. He has two copies of the APOE4 gene and has watched both of his parents succumb to the disease. To be clear, I would do witchcraft if it meant he will remember my name when we're both in the retirement home. We bring back What Gen Zers Are Saying, Penn Compliments Men (shout out to Dan!), and a very relatable story on the Laugh Line about a deer, a college kid, and a callback. Thanks for laughing along with us. We love to hear from you! Leave us a message at 323-364-3929 or write the show at podcast@theholdernessfamily.com. You can also watch our podcast on YouTube.Learn more about our new kids book!Hear Dan's viral song parody!Visit Our ShopJoin Our NewsletterFind us on SubstackFollow us on InstagramFollow us on TikTokFollow us on FacebookLaugh Lines with Kim & Penn Holderness is an evolution of The Holderness Family Podcast, which began in 2018. Kim and Penn Holderness are award-winning online content creators known for their original music, song parodies, comedy sketches, and weekly podcasts. Their videos have resulted in over three billion views and over nine million followers since 2013. Penn and Kim are also authors of the New York Times Bestselling Books, ADHD Is Awesome: A Guide To (Mostly) Thriving With ADHD and All You Can Be With ADHD. They were also winners on The Amazing Race (Season 33) on CBS. Laugh Lines is hosted and executive produced by Kim Holderness and Penn Holderness, with original music by Penn Holderness. Laugh Lines is also written and produced by Ann Marie Taepke, and edited and produced by Sam Allen. It is hosted by Acast. Thanks for listening! Hosted on Acast. See acast.com/privacy for more information.

In this episode of SHE MD, Mary Alice Haney sits down with preventative neurologist Dr. Kellyann Niotis to unpack what every woman needs to know about brain health, memory, and dementia prevention. From understanding the difference between normal forgetfulness and early warning signs to breaking down how working memory changes with age, this conversation offers clarity, reassurance, and actionable insight. Dr. Niotis explains why women are disproportionately affected by Alzheimer's disease and how factors like hormones, genetics, and lifestyle all play a role.They explore the most powerful, research-backed ways to protect your brain, starting with the basics: sleep, exercise, nutrition, and stress management. You'll learn why strength training is critical for long-term brain health, how the Mediterranean diet can reduce dementia risk by up to 35%, and why your genes are not your destiny, even if you carry high-risk markers like APOE4. The episode also dives into mental health, social connection, and the surprising link between hearing loss and cognitive decline.Dr. Niotis shares what actually works (and what doesn't) when it comes to supplements, brain games, and trending “quick fixes,” along with emerging research on medications, biomarkers, and preventative care. If you want to stay sharp, protect your memory, and take control of your long-term brain health, this episode is filled with practical tools you can start using today.Subscribe to SHE MD Podcast for expert tips on PCOS, endometriosis, fertility, hormonal balance, mental health, and more. Share with friends and visit SHE MD website and Ovii for research-backed resources, holistic health strategies, and expert guidance on women's health and well-being.SponsorsMidi: Ready to feel your best and write your second act script? Visit JoinMidi.com today to book your personalized, insurance-covered virtual visit. Myriad: List GetMyRisk.com to learn more about hereditary cancer testing and how you can use Myriad's virtual care option for fast, at-home testing - no office visit required. Osea: Get 10% off your first order sitewide with code SHEMD at oseamalibu.com. Momentus: Get up to 35% off your first order at livemomentous.com with code SHEMD.Ka'Chava: Get 15% off your first order at kachava.com with code SHEMD.What You'll LearnThe difference between normal forgetfulness and early signs of dementiaWhy working memory declines and how to support itHow sleep quality (not just quantity) impacts brain healthThe best types of exercise for protecting your brain long-termWhy strength training is critical (and often overlooked) for womenHow the Mediterranean diet can reduce dementia risk by up to 35%The connection between hormones, perimenopause, and brain healthWhy women are more affected by Alzheimer's disease than menHow stress, isolation, and mental health impact cognitive declineThe truth about supplements, nootropics, and “brain boosters”How alcohol, marijuana, and emerging therapies affect the brainWhy hearing loss is a major (and surprising) risk factor for dementiaThe role of biomarkers, genetics, and preventative testingKey Timestamps(0:00) Introduction to SHE MD(3:47) Meet Dr. Kellyann Niotis (Brain Health Expert)(5:01) Genetics, Risks, and APOE4(8:34) Brain Diseases: Alzheimer's vs Parkinson's vs ALS(10:28) How Doctors Assess Brain Health Risk(12:01) Sleep & Brain Health(19:05) Best Type of Exercise for Your Brain(29:05) Nutrition & The Mediterranean Diet(29:50) Alcohol, Marijuana & Brain Impact(33:53) GLP-1s & Brain Health Benefits(36:37) Mental Health, SSRIs & Dementia Risk(39:17) Why Women Are More Affected(43:31) Memory Loss vs Normal Forgetfulness(45:13) Hormone Therapy & Brain Health(49:19) Supplements That Actually Help(51:58) Omega-3 Testing & Recommendations(57:38) Is There a Dementia Epidemic?(1:00:59) Working Memory Explained(1:02:45) Rapid Fire Questions(1:06:11) Audience Q&A (Prevention, Diet, Memory)(1:08:06) Future of Brain Health & New Research(1:10:23) Where to Find Dr. NiotisKey TakeawaysYour genes are not your destiny. Lifestyle plays a major role in brain healthSleep, exercise, diet, and social connection are the most powerful prevention toolsStrength training is just as important as cardio for cognitive healthChronic stress and poor sleep are both highly damaging to the brainHormonal changes in perimenopause may increase dementia risk in womenBrain games alone won't prevent dementia, holistic lifestyle changes are keyEven small improvements in daily habits can significantly reduce riskPrevention is currently the most effective strategy against neurodegenerative diseaseGuest BioDr. Kellyann Niotis is a leading expert in preventative neurology and brain health. She specializes in identifying early risk factors for neurodegenerative diseases like Alzheimer's and Parkinson's and helping patients take proactive steps to protect their cognitive health. Through her research and clinical work, she focuses on translating cutting-edge science into practical, everyday strategies for long-term brain optimization.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world.Today, we delve into recent significant advancements and strategic maneuvers reshaping the landscape in these dynamic industries. AstraZeneca has made a notable stride with its chronic obstructive pulmonary disease (COPD) drug candidate, achieving remarkable efficacy in Phase 3 trials. This success is particularly significant given the historical challenges in this therapeutic area, where competitors like Roche and Sanofi have struggled to deliver consistent results. AstraZeneca's achievement not only highlights its innovative clinical development strategies but also offers renewed hope for COPD patients who have long awaited more effective treatment options.In a parallel move, AstraZeneca is pioneering in vivo CAR-T cell therapies, showcasing their potential despite safety concerns following a patient death during trials in China. The therapy's ability to eradicate cancer in three out of five patients underscores its promise as a revolutionary treatment for cancer, illustrating the need for ongoing safety evaluations as this technology develops.Meanwhile, Novartis continues to strategically expand its allergy treatment portfolio with a significant $2 billion acquisition of Excellergy. This deal centers around an anti-IgE program poised to potentially replace Xolair, Novartis's leading allergy medication. Such strategic moves underscore Novartis's commitment to remaining at the forefront of allergy therapeutics by harnessing biotechnological innovations to develop next-generation treatments. This acquisition complements existing assets like Xolair, an IgE blocker now approved for treating food allergies across different age groups, aiming to bolster Novartis's competitive edge in allergy therapeutics by providing a broader array of solutions.Otsuka Pharmaceutical is also making waves with its $1.2 billion acquisition of Transcend Therapeutics. This acquisition focuses on an MDMA analog for psychiatric conditions, marking Otsuka's deepening interest in mental health therapeutics and the burgeoning field of psychedelic compounds as viable psychiatric treatments. This move reflects a broader industry trend towards exploring unconventional therapeutic avenues to address complex mental health issues.On the regulatory front, Takeda is undergoing significant restructuring efforts aimed at achieving $1.3 billion in annual savings through reorganization. This reflects a broader industry trend towards optimizing operations to enhance efficiency and maintain competitiveness in an ever-evolving market landscape.In another noteworthy development, Rocket Pharmaceuticals has secured accelerated FDA approval for Kresladi, a gene therapy targeting severe leukocyte adhesion deficiency-1. This approval highlights the growing potential of gene therapies to meet unmet medical needs for rare diseases and sets an important precedent for other companies seeking expedited regulatory pathways for their gene therapy pipelines.In Alzheimer's research, both Eisai and Alzheon have made significant contributions, especially regarding high-risk patient subsets. Eisai presented real-world data on Leqembi at the AD/PD annual meeting, demonstrating safety and efficacy in patients with specific genetic profiles like APOE4 homozygotes. Concurrently, Alzheon provided insights into its candidate's performance in similar cohorts. These findings underscore personalized medicine's growing importance in neurodegenerative disease treatment.Oncology remains a critical area with Merck's announcement of its planned acquisition of Terns Pharmaceuticals for $6.7 billion. Driven by Terns' promising leukemia drug developments, this acquisition exemplifies how major players are diversifying their oncology pipelines to maintain market leadership amid approaching patent expiraSupport the show

La enfermedad de Alzheimer afecta a más de 55 millones de personas en el mundo. Pero lo que la mayoría no sabe es que hasta el 45% de los casos podrían evitarse o retrasarse. Y que un simple análisis de sangre podría detectar la enfermedad hasta 20 años antes de que aparezca el primer síntoma. En esta conversación con la neurocientífica Sonia Villapol — investigadora en el Houston Methodist Research Institute, experta en neuroinflamación, nutrición y daño cerebral — recorremos el estado real de la ciencia del Alzheimer en 2026: desde la genética que determina quién tiene más riesgo, hasta los tratamientos que por primera vez en la historia están llegando a Europa. Hablamos de los 14 factores de riesgo modificables que la Comisión Lancet ha identificado y que están en nuestras manos controlar. Hablamos del gen APOE4 — presente en casi el 25% de la población — y de un estudio reciente publicado en Nature que concluye que sin los alelos ε3 y ε4, la inmensa mayoría de los casos de Alzheimer sencillamente no ocurrirían. Hablamos de lo que el café, el sueño, el ejercicio y la microbiota intestinal pueden hacer por tu cerebro. De cómo un golpe en la cabeza puede desencadenar una cascada inflamatoria que acelera la neurodegeneración años después. De por qué las personas que han superado un cáncer parecen tener menos riesgo de desarrollar Alzheimer. Y del dato más esperanzador: que los centenarios podrían guardar claves de protección frente a la demencia que aún no entendemos del todo. Una conversación para entender que el Alzheimer no es solo una enfermedad del olvido. Es una enfermedad que se gesta durante décadas, en silencio, y por primera vez contamos con herramientas reales para interceptarla.

This week, Dr. Kahn breaks down new research on dementia risk, including the roles of high blood pressure and early menopause. He looks at conflicting studies on red meat and ApoE4, which pretty much sums up nutrition science: one study says yes, another says absolutely not. For now, limiting red meat—especially processed—is still the safest move. He also covers the risks of skipping breakfast, calcium CT scoring for elevated lipoprotein(a), tooth loss and heart disease, long-term clopidogrel use after stents, ultraprocessed foods, Repatha and statins, Cleerly AI scans, micro-exercise breaks, and why elevated TMAO may increase blood clot risk.  This episode is sponsored by Igennus. Visit igennus.com and use code DRKAHN for a discount.

Dr. Heather Sandison was told in medical school that suggesting you could help someone with Alzheimer's was promoting false hope. Then she ran a clinical trial and 74% of participants with measurable cognitive impairment improved in six months.In this episode, Dr. Sandison breaks down the five things you can start doing today to protect your brain - no doctor visit required - and explains why the conventional approach to Alzheimer's has failed, what her clinical trial revealed, and how she's working to make Alzheimer's optional in this generation.We discuss:- Why the amyloid hypothesis has failed after billions of dollars and decades of research- The clinical trial results: 74% of cognitively impaired participants improved in 6 months- Five actionable brain health strategies: blood sugar control, sleep, exercise, toxin reduction, and stress management- Why continuous glucose monitors (CGMs) are a powerful first step- The critical role of sleep and glymphatic brain detox in preventing neurodegeneration- Dual-task exercise: why pickleball, dancing, and Pilates beat the treadmill for brain health- Toxins as a causal factor: mercury, glyphosate, microplastics, and mycotoxins- APOE4 genetic risk: what it means and what you can do about it starting young- The ketosis connection: a patient who recognizes his grandkids in ketosis and doesn't without it- Comprehensive functional medicine testing: what to ask for and why- Glyphosate in U.S. grains: why people can eat bread in Europe but not America- Marama: the residential memory recovery program changing Alzheimer's care- Why Alzheimer's, diabetes, cancer, and mental illness share the same root causes- Dr. Sandison's one request: optimize your sleep tonightGuest: Dr. Heather Sandison, NDWebsite: Solcere Health (solcere.com) | Marama (myvibrantvita.com)Book: "Reversing Alzheimer's: The New Toolkit to Improve Cognition and Protect Brain Health" - NYT Bestseller, available on Amazon and wherever books are soldMentioned in this episode:- Dr. Dale Bredesen - Bredesen Protocol- Chris Palmer, MD - Brain Energy / Ketogenic therapy for mental illness- Thomas Seyfried - Cancer as a metabolic disease- P-tau 217 - Early Alzheimer's biomarker- Stelo and Lingo - Over-the-counter continuous Continue this conversation on SubStack: https://robertlufkinmd.substack.com Get 120 Biomarkers for $99 and CT Calcium scans anywhere in the US. https://www.vitalsvault.com/ Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/ Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter takes a deep dive into obicetrapib, an investigational drug that has captured his attention and renewed interest in an entire class of therapies known as CETP inhibitors. He explains what obicetrapib is and how it works, revisits the history of CETP inhibitors and why earlier versions of these drugs failed—sometimes dramatically—and breaks down the key clinical trials designed to evaluate their impact on cardiovascular risk. Peter examines how obicetrapib influences major lipid biomarkers, including LDL cholesterol and lipoprotein(a) [Lp(a)], and discusses emerging evidence from a study that explored the drug's effects on Alzheimer's-related blood biomarkers. He also highlights intriguing findings in individuals carrying the APOE4 allele and reflects on what these early results may mean for both cardiovascular disease prevention and potential implications for Alzheimer's risk, as well as how he is thinking about this therapy in the context of caring for his own patients. We discuss: Introducing obicetrapib: CETP inhibitor history, lipid biology, and early Alzheimer's biomarker signals in APOE4 carriers [2:15]; CETP biology explained: lipoproteins, reverse cholesterol transport, and how CETP inhibition alters HDL and LDL particles [5:15]; The early CETP inhibitor story: why raising HDL cholesterol alone failed to deliver cardiovascular protection [13:45]; The rise and fall of early CETP inhibitors: torcetrapib, dalcetrapib, evacetrapib, and anacetrapib [18:30]; Why obicetrapib may succeed where earlier CETP inhibitors failed [23:30]; The BROADWAY trial: obicetrapib's effects on LDL, ApoB, Lp(a), and residual cardiovascular risk [26:00]; Brain lipid metabolism and APOE4: how CETP inhibition may influence cholesterol transport in Alzheimer's disease [30:45]; Findings from the substudy of the BROADWAY trial which looked at changes in biomarkers of Alzheimer's disease [40:00]; Interpreting the BROADWAY Alzheimer's biomarker results: limitations, cautious optimism, and the need for a dedicated prevention trial [46:45]; Why Peter is optimistic about obicetrapib: cardiovascular benefits, Lp(a) reduction, and the path toward approval [50:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Explore 30–200 root causes of Alzheimer's including sleep, inflammation, ApoE4, and lifestyle habits that either prevent or accelerate cognitive decline. #AlzheimersCauses #Inflammation #GeneticsAndLifestyle #CognitiveCare

What if Alzheimer's, multiple sclerosis, chronic fatigue, and even psychiatric symptoms are not random but driven by hidden infections? In this episode of Integrative Lyme Solutions, Dr. K sits down with research scientist and Lyme survivor Nikki Schultek to explore the infection hypothesis behind chronic disease. After battling years of misdiagnosed symptoms including asthma flares, interstitial cystitis, arrhythmias, neurological decline, and suspected MS, Nikki uncovered a complex web of infections including Borrelia, Bartonella, Babesia, Chlamydia pneumoniae, Epstein-Barr virus, and more. Now founder of the Alzheimer's Pathobiome Initiative, Nikki is leading a global consortium investigating how stealth pathogens may trigger neurodegeneration, immune dysfunction, and dementia. This conversation dives into intracellular infections, the Herxheimer reaction, amyloid as an antimicrobial response, sterile brain autopsies, precision medicine, and why federal health agencies are finally acknowledging Lyme disease as a serious public health crisis. If you or someone you love is dealing with chronic Lyme, long COVID, autoimmune illness, or cognitive decline, this episode may change how you see disease. Key Takeaways: 0:00 Introduction 3:15 Asthma, air hunger, and early misdiagnoses 8:40 From interstitial cystitis to suspected multiple sclerosis 14:30 Discovering intracellular infections and Chlamydia pneumoniae 18:45 Lyme, Bartonella, Babesia and the whack-a-mole effect 24:10 The Pathobiome concept and microbial imbalance 27:30 Alzheimer's disease and the infection hypothesis 32:00 Sterile brain autopsies and spinal fluid research 35:20 Amyloid plaque as an antimicrobial defense mechanism 41:00 APOE4, genetics, and infection susceptibility 44:30 Federal recognition of Lyme disease and future funding Resources Mentioned: Alzheimer's Pathobiome Initiative - https://alzheimerspathobiome.org ILADS - https://www.ilads.org ILADS Education Foundation - https://www.iladef.org Philadelphia College of Osteopathic Medicine - https://www.pcom.edu Medical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions. _______________________________The Karlfeldt Center offers the most cutting-edge and comprehensive Lyme therapies. To schedule a Free 15-Minute Discovery Call with a Lyme Literate Naturopathic Doctor at The Karlfeldt Center, call 208-338-8902 or email info@TheKarlfeldtCenter.comCheck out Dr. K's Ebook: Breaking Free From Lyme: A Comprehensive Guide to Healing and Recovery here: https://store.thekarlfeldtcenter.com/products/breaking-free-from-lymeUse the code LYMEPODCAST for a 100% off discount!

Dr. Kim Brockenbrough: https://www.cardiavision.com/https://www.linkedin.com/in/kimberly-brockenbrough-md-1b321a123/https://www.instagram.com/kimbromd?ighsh=YjVpcDcwdHA3ejVvYour calcium score came back zero. You're in the clear, right? Not so fast.In this episode, Optispan Clinical Director Dr. Nicki Byrne sits down with Dr. Kim Brockenbrough, board-certified cardiovascular radiologist, 25-year veteran of vascular imaging, and CEO of CardiaVision, for a conversation that challenges one of the most common assumptions in preventive cardiology.If you care about cardiovascular longevity, and you should, because heart disease remains the leading killer, this is the imaging conversation you didn't know you needed.Timestamps:00:00 — Cold open: The 48-year-old runner with an 80% blockage and a zero calcium score00:54 — Dr. Nicki Byrne introduces Dr. Kim Brockenbrough & CardiaVision01:45 — Dr. Brockenbrough's background: 25 years of vascular imaging02:35 — Cardiovascular disease through a longevity lens: imaging vs. labs vs. functional testing03:24 — The lifecycle of plaque: from fatty deposits to rupture and heart attack04:21 — Why soft plaque is more dangerous than calcified plaque (SCOT-HEART 2020)05:14 — How calcium scores are used in clinical practice — and where they fall short06:18 — The only way to see soft plaque non-invasively: coronary CT angiography (CCTA)07:08 — Which populations are most at risk of a false sense of security from calcium scoring08:03 — What a CCTA can tell you that a calcium score can't09:43 — How often should patients follow up with repeat scans?10:28 — Higher vs. lower dose radiation protocols — and why Dr. Brockenbrough chooses higher dose11:17 — Risks of CCTA: contrast reactions, kidney considerations12:15 — Stress tests vs. CCTA: why a negative stress test is a very low bar13:21 — Soft plaque that isn't flow-limiting: small emboli, dementia, and congestive heart failure15:36 — Medications that reverse plaque: statins, PCSK9 inhibitors, and the LOCATE trial16:23 — LDL reduction and plaque regression: what the data shows17:08 — High-intensity statins vs. Repatha — tolerability, efficacy, and the price drop18:27 — When OptiSpan reaches for PCSK9 inhibitors: ApoB, LDL, Lp(a), ApoE4, and significant disease19:22 — Why a rising calcium score on a statin is exactly what you want to see20:25 — AI plaque quantification tools: promise, limitations, and validation concerns22:54 — Has AI ever changed Dr. Brockenbrough's read? A real-world case23:40 — FFR-CT, the ISCHEMIA trial, and why stenting asymptomatic patients is no longer standard of care25:25 — The future of cardiac imaging and the case for universal CCTA screening26:52 — The patient experience: what to expect at a CardiaVision CCTA appointment28:18 — Why seeing soft plaque changes patient behavior — the power of treating disease, not numbers29:49 — Bridging the gap between longevity medicine and traditional cardiology33:11 — Testosterone, the TRAVERSE trial, and what you should know about your coronaries first35:41 — What causes coronary artery disease beyond cholesterol: sugar, inflammation, gum disease37:07 — Image walkthrough: soft plaque vs. calcified plaque on a real CCTA41:36 — Where to find Dr. Brockenbrough and CardiaVision

View This Week's Show NotesStart Your 7-Day Trial to Mobility CoachJoin Our Free Weekly Newsletter: The AmbushWhat if the biggest predictor of dementia isn't your genes — but your metabolic health?In this episode, neuroscientist and performance coach Dr. Tommy Wood reveals why blood sugar regulation and blood pressure are more powerful predictors of Alzheimer's disease and cognitive decline than amyloid plaques or even genetics like ApoE4.For decades, Alzheimer's has been framed as either a genetic lottery or the inevitable buildup of amyloid in the brain. But emerging research shows that metabolic dysfunction, insulin resistance, and vascular health may play a far greater role in determining long-term brain outcomes.Instead of focusing on fear, this conversation delivers a practical blueprint for building cognitive reserve and “cognitive headroom” — the brain's ability to stay resilient, adaptable, and high-performing as you age.You'll learn why crossword puzzles aren't enough, how high-intensity exercise and resistance training stimulate brain-derived neurotrophic factors (BDNF), why lactate may act like “Miracle-Gro” for your neurons, and how to interpret early warning signs like subjective brain fog.What You'll Learn in This EpisodeWhy Alzheimer's isn't just about amyloid plaquesThe powerful link between blood sugar and cognitive declineHow genetics (like ApoE4) increase risk — but don't seal your fateWhat “cognitive headroom” means and how to build itWhy high-intensity exercise may act as Miracle-Gro for the brainThe surprising role of resistance training in brain healthWhat subjective brain fog might be telling youHow menopause affects cognition — and what's reversibleWhy boredom and focus matter more than we thinkThe kinds of skills you should keep practicing as you ageFor women navigating perimenopause and menopause, Dr. Wood explains what cognitive changes are hormonally driven, what's reversible, and how to protect long-term brain health.Whether your goal is preventing Alzheimer's disease, improving focus and processing speed, or becoming a cognitive “superager,” this episode provides evidence-based strategies to help you build a brain that is robust, metabolically healthy, and built to last.Key Highlights: (00:00) – Brain Health & Cognitive Longevity Intro(00:35) – Brain Evolution & Survival Mechanisms(02:53) – Diabetes & Alzheimer's Disease Link(07:31) – Genetic Risk & Dementia Family History(11:32) – Expanding Brain Capacity & Headroom(15:08) – Cognitive Reserve & Brain Resilience(19:55) – Preventing Age-Related Cognitive Decline(23:00) – Exercise Data for Brain Health(26:16) – Best Exercises for Cognitive Function(35:11) – Amyloid Plaques & Alzheimer's Pathology(38:00) – Amyloid-Targeting Drugs & Treatments(40:31) – Subjective Cognitive Decline Measures(45:04) – Testing & Measuring Brain Performance(49:58) – Menopause & Female Brain Health(56:10) – Aging Brain, Wisdom & Intelligence(1:05:00) – Cognitive Processing Speed & Aging(1:07:07) – Benefits of Boredom for the Brain(1:12:17) – Book Recommendations for Mental GrowthConnect with Dr. Tommy WoodWebsite | Substack | InstagramPre-Order The Stimulated Mind for tons of extra perks!Huge thanks to our sponsors, Momentous, Vitality, and LMNT.

We're answering listener questions on topics such as the APOE4 gene, weight management with Ozempic, the effectiveness of the Yuka app, Herbalife shakes, and hydration while taking creatine.

Menopause Mastery Show | Starting HRT After 65: Is It Too Late? Transdermal Estrogen and Bone, Sleep & Dementia Risk   Welcome to Menopause Mastery! In this episode, Dr. Betty Murray examines whether starting menopausal hormone therapy after age 65 is always unsafe, arguing that blanket "no" answers stem from an evidence vacuum and fear following the 2002 Women's Health Initiative (WHI), which used oral conjugated equine estrogen and synthetic progestins.    Dr. Murray contrasts oral therapy's first-pass liver metabolism and clotting risk with transdermal bioidentical estradiol, which has observational and retrospective data (including a large Medicare analysis) associated with no increased DVT, stroke, or heart attack risk. She highlights evidence for fracture reduction and maintained vertebral bone density with long-term therapy, discusses sleep benefits (a modifiable dementia risk factor), notes limited cognitive trials in older starters, and emphasizes individualized risk assessment (cardiovascular screening, genetics like APOE4) and monitoring; she also recommends vaginal estrogen to reduce UTIs and urosepsis risk.    This episode is for women who feel they may have missed their window on starting HRT, and why it may not be too late. In fact, women of all ages will benefit from this information, so don't forget to share it with someone you know!    00:00 HRT After 65 02:36 The Evidence Vacuum 04:55 Myth of the Window 06:27 WHI vs Modern Estrogen 08:36 Transdermal Safety Data 10:08 Why Observational Counts 14:51 Risk Math in Your 70s 19:32 Bone Density Benefits 23:08 Sleep and ApoE4 24:30 APOE4 Risk Basics 25:07 Sleep as Brain Protection 25:55 Transdermal Estrogen for Sleep 27:12 Insomnia Raises Dementia Risk 28:22 Personalizing HRT for Sleep 30:03 Cardiovascular Risks and Screening 34:56 Evidence Gaps and WHI Context 38:38 APOE4 Sleep and Estradiol Link 40:09 Decision Framework Over 65 43:08 Monitoring and Follow Up 45:47 Alternatives and Tradeoffs 48:16 Vaginal Estrogen and Wrap Up   Connect with Dr. Betty Murray:  Betty Murray Website: https://www.bettymurray.com/ Instagram: https://www.instagram.com/drbettymurray/   Like, comment, and subscribe on YouTube:  @drbettymurray     Links:  The Fierce Female Method for Longevity (Dr. Betty's book): https://fierce.hormoneshelp.com/  Menrva Telemedicine: https://gethormonesnow.com/  FREE Hormone Quiz: https://bit.ly/3wNJOec  Living Well Dallas: https://www.livingwelldallas.com/  Hormone Reset: https://hormonereset.net/   More from the Podcast:  Subscribe to #MenopauseMastery → https://www.youtube.com/channel/UCwONPdSvb2-YYY74VhD-XBw  Apple Podcasts → https://podcasts.apple.com/us/podcast/menopause-mastery/id1607369247  Spotify → https://open.spotify.com/show/0tNsjm32CZNXSgSFEwS3uH   Thank you for listening to Menopause Mastery. Empowering your health journey, one episode at a time.  

Conversations about brain health have been dominated by a competing mix of fatalism and over-promising, with aging framed as inevitable decline and "brain optimisation" sold through weak evidence. So how should we think about cognition across the lifespan? In this episode, we explore the idea that neuroplasticity does not disappear in adulthood, but instead continues to respond, for better or worse, to repeated behaviours and exposures. Much of what is labelled age-related cognitive decline may in fact reflect an accumulation of modifiable risk factors. We also dig into how to critically evaluate brain-health claims and how lifestyle pillars such as exercise, sleep, diet, stress reduction and cognitive training fit into a coherent framework. The discussion extends to emerging multimodal intervention programs, their promising signals and their clear limitations, and to a broader, multifactorial view of Alzheimer's disease that moves beyond a narrow amyloid-centric model. Finally, we examine the role of genetics, including ApoE4, and why genetic risk does not equate to biological destiny, even later in life. Dr. Majid Fotuhi is a neurologist and an adjunct professor at the Johns Hopkins Mind/Brain Institute. He earned his medical degree from Harvard Medical School and completed a Ph.D. in neuroscience at Johns Hopkins University. That was followed by internship and neurology residency at Johns Hopkins Hospital. Timestamps [03:41] Understanding neuroplasticity [05:22] Risk factors for cognitive decline [07:07] Evidence-based interventions for brain health [09:37] The five pillars of brain health [10:42] Dr. Fotuhi's multimodal program [19:09] Measuring cognitive function [24:43] The role of amyloid and tau in Alzheimer's [27:53] Genetics and lifestyle in brain health [30:03] Debunking myths and overhyped claims [36:08] Key ideas segment (premium subscribers only) Related Resources Go to episode page (with links to studies mentioned) Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course Dr. Fotuhi's book: The Invincible Brain

  In this episode, Freddie and Renee zoom out on the modern wellness landscape—where tech, supplements, scans, and strong opinions are everywhere—and make a case for discernment over dogma. They talk candidly about online criticism, influencer skepticism, and why “trying things” only works when you introduce tools one at a time, track outcomes (HRV, sleep, glucose), and don't confuse information with wisdom. The through-line is simple: foundational health still matters, but intelligent experimentation can be powerful when it's paired with humility and real feedback loops. Then the conversation goes deep into two high-stakes areas people rarely discuss honestly: full-body MRI screening and biological dentistry. Renee shares her Prunuvo experience—how a possible kidney finding triggered weeks of stress and a cascade of follow-up imaging and specialist visits, raising the hard question of where early detection ends and false positives begin. From there, she opens up about a long dental arc that started with a traumatic accident at 16, eventually leading her to remove older titanium implants, manage bone loss and grafting, and transition to zirconia ceramic implants—not as fear-based medicine, but as a “reduce the burden” choice while she explores chronic fatigue, immune markers, and Episode Highlights [00:00] – Renee's Pranuvo full-body MRI experience and the 15mm kidney stone scare [16:02] – False positives, medical rabbit holes, and the emotional/financial cost of early detection [22:53] – Top health yardsticks: glucose markers, HRV, sleep tracking, and foundational labs [25:08] – CGMs, cortisol testing (Dutch & ELi Health), and why trends matter more than single data points [27:15] – Genetic testing, APOE4 status, and using DNA as a focus tool (DNA Company & SelfDecode) [51:37] – Renee's dental trauma story: accident, titanium implants, and root canal decisions [54:56] – Titanium implants, ANA positivity, chronic fatigue, and biocompatibility concerns [59:22] – Surgery recovery protocol: red light therapy, StemRegen, BPC-157 & TB-500 peptides [01:29:10] – Closing reflections and exosome therapy mention   Links & Resources Learn more about Renee Belz → https://reneebelz.com/ Follow Renee on Instagram → https://www.instagram.com/reneebelz/ Listen to the Biohacker Babes: https://podcasts.apple.com/us/podcast/renee-belz-lauren-sambataro/id1470189843 Get Silver Biotics: bit.ly/3JnxyDD — 30% off with Code: BEAUTIFULLYBROKEN Try CatchBio: https://catchbio.com — Code: BEAUTIFULLYBROKEN LightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794 — Code: beautifullybroken StemRegen: stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52 — Code: beautifullybroken   CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, I sit down with neuroscientist Dr. Louisa Nicola to unpack what women actually need to know about Alzheimer's risk, cognitive decline, and long term brain protection. We break down APOE genetics, advanced blood biomarkers that can now detect amyloid and tau with remarkable accuracy, and why brain health is inseparable from metabolic health. Louisa explains how muscle acts as a metabolic sink for glucose, why resistance training and high intensity intervals stimulate BDNF, and how sleep drives the glymphatic system to clear amyloid from the brain. If you want practical tools to assess your personal risk, understand your labs, and build a proactive prevention plan decades before symptoms appear, this conversation is for you. → Leave Us A Voice Message!  Topics Discussed: → What does APOE4 mean for Alzheimer's risk? → Can exercise prevent cognitive decline? → Do blood tests detect early Alzheimer's? → How does perimenopause affect brain health? → Does hormone therapy reduce dementia risk? Sponsored By:  → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/KELLY and save up to 39% off your Mitopure® Gummies. → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com. → Cozy Earth |  Head to https://cozyearth.com and use code BEWELL for up to 20% off. And if you get a post-purchase survey, make sure you tell them you heard about Cozy Earth right here at the Be Well by Kelly podcast.  → LMNT | Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at https://drinklmnt.com/Kelly. Find your favorite LMNT flavor, or share with a friend. Timestamps:  → 00:00:00 - Introduction → 00:01:27 - Mission to end Alzheimer's  → 00:03:28 - Women's rate of Alzheimer's  → 00:04:11 - Alzheimer's overview  → 00:07:44 - Education level & health  → 00:09:57 - Anatomy  → 00:14:16 - Neuroplasticity & glucose  → 00:19:38 - Amyloid-beta → 00:26:41 - LDL Cholesterol → 00:28:36 - Preparing for menopause  → 00:31:30 - Blood testing recommendations  → 00:34:26 - Lifestyle interventions  → 00:39:05 - Nutrition & the MIND diet  → 00:42:19 - Zone 2 vs zone 5 training  → 00:44:36 - Lactic acid  → 00:47:58 - HRT is protective → 00:50:19 - When to test for HRT → 00:51:56 - Testosterone + brain health  → 00:53:40 - Cognitive reserve  → 00:57:12 - Hot flashes  → 00:58:13 - Quick fixes  → 01:00:01 - Brain surgery  → 01:05:38 - The brain code  Show Links: → Function | Own your health for $365 a year. That's a dollar a day. Learn more and join using my link. Visit https://www.functionhealth.com/bewellbykelly and use gift code BEWELL25 for a $25 credit toward your membership Further Listening: → How to Take Control of Your Health in a Toxic Food Landscape | Max Lugavere  Check Out Louisa:  → Instagram  → The Brain Code Check Out Kelly: → Instagram → Youtube → Facebook

In this episode, Dr. David Jockers explains the latest research on saturated fat and its role in heart disease. He breaks down why many studies don't link saturated fat to higher heart disease risk and what factors actually matter when assessing fat consumption.   You'll discover why oxidative stability, not the smoke point, is the real key when choosing fats for cooking. Dr. Jockers shares which fats are most stable and why they're better for your health in the long term.   We also dive into the role saturated fat plays for those with specific genetic markers, like APOE4 carriers. Dr. Jockers discusses how certain individuals might need to limit their intake of saturated fats to improve their health outcomes. In This Episode:  00:00 Oreo Cookies vs. Statins: Surprising Cholesterol Findings 00:16 Introduction to Saturated Fat and Heart Disease 03:31 The Lipid Hypothesis and Saturated Fat 04:30 Debunking Myths: Studies on Saturated Fat 08:56 The Role of Saturated Fat in Cell Health 10:45 Best Sources of Saturated Fats 14:38 When Saturated Fat Can Be Problematic 18:35 Cooking with Saturated Fats 20:03 Conclusion and Final Thoughts When it comes to cooking, Chef Foundry offers the perfect solution with their P 600 ceramic cookware, which is free from Teflon, PFAS, and plastic coatings. Made with Swiss-engineered ceramic, this cookware makes it easy to prepare healthy meals without the toxins. Take 20% off with code SAFE20 at chefsfoundry.com/jockers and upgrade your kitchen today.   Scientists have discovered that hair loss is not caused by aging, but by hair follicles getting switched off. AnaGain Nu, a clinically studied compound derived from pea sprouts, is designed to reactivate dormant hair follicles and support visible regrowth. Purity Health combines AnaGain Nu with their advanced liposomal delivery system to improve absorption and effectiveness. Right now, you can try it with a buy one, get one free offer, backed by a 180-day money-back guarantee, giving you six months to see results risk-free. Visit https://renewyourhair.com/drj to access this exclusive deal.   "If you don't break down the fats well, they can be a carrier for bad gut microbes to get into the bloodstream."  ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit chefsfoundry.com/jockers for 20% off with code SAFE20. Visit https://renewyourhair.com/drj Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

This interview was brought to you in partnership with Eisai and is part of the Journey to Diagnosis series.Eisai: https://www.eisai.com/index.htmlJourney to Diagnosis: https://beingpatient.com/journey-to-diagnosis/Luke Davis spent four decades as a Dallas attorney — and an active husband, father, youth sports coach and school board member — before subtle memory changes raised concerns. In this Being Patient Perspectives interview, Luke and his wife, Paula Davis, share the early signs of Alzheimer's they noticed first, how they pursued answers, and what helped them move forward.After a primary care visit, Luke underwent cognitive testing, an MRI and an amyloid PET scan that confirmed plaque. In April 2023, just before his 69th birthday, he was diagnosed with early-stage Alzheimer's disease. Luke later learned he carries two copies of the APOE4 gene, a major genetic risk factor for Alzheimer's.Luke and Paula also discuss treatment and support — including Luke's experience with Leqembi (lecanemab) infusions — and how they've leaned on the Alzheimer's Association, community, and practical day-to-day strategies. Their message for newly diagnosed individuals and couples: Alzheimer's is a detour, not a dead end — and Luke is focused on “living with Alzheimer's, not dying from it.”Topics covered: early Alzheimer's symptoms, diagnosis journey, amyloid PET scan, APOE4, Leqembi/lecanemab, caregiving as a spouse, coping after diagnosis, living well with Alzheimer's, advocacy and support.#Alzheimers #EarlyAlzheimers #Leqembi #Lecanemab #APOE4 #Dementia #BrainHealth #BeingPatient---- If you loved watching this Live Talk, visit our website to find more of our Alzheimer's coverage and subscribe to our newsletter: https://www.beingpatient.com/Follow Being Patient: Twitter: https://twitter.com/Being_Patient_Instagram: https://www.instagram.com/beingpatientvoices/Facebook: https://www.facebook.com/beingpatientalzheimersLinkedIn: https://www.linkedin.com/company/being-patientBeing Patient is an editorially independent journalism outlet for news and reporting about brain health, cognitive science, and neurodegenerative diseases. In our Live Talk series on Facebook, former Wall Street Journal Editor and founder of Being Patient, Deborah Kan, interviews brain health experts and people living with dementia. Check out our latest Live Talks: https://beingpatient.com/live-talks/

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Lisa Mosconi is a world-renowned neuroscientist and the director of the Women's Brain Initiative at Weill Cornell Medicine, where she studies how sex differences and hormonal transitions influence brain aging and Alzheimer's disease risk. In this episode, Lisa explores why Alzheimer's disease disproportionately affects women and why longer lifespan alone does not explain their nearly twofold risk compared to men. She explains why Alzheimer's disease may be best understood as a midlife disease for women, beginning decades before symptoms appear, and how menopause represents a fundamental brain event that reshapes brain energy use, structure, and immune signaling. The conversation also examines what advanced brain imaging reveals about preclinical Alzheimer's disease, estrogen receptors in the brain, and why genetic risks such as APOE4 appear to affect women differently from men. Finally, Lisa discusses the nuanced evidence around menopause hormone therapy, the legacy of the WHI, her new CARE Initiative to cut women's Alzheimer's risk in half by 2050, and practical, evidence-based strategies to support brain health through midlife—including lifestyle, sleep, metabolism, mood, and emerging therapies such as GLP-1 agonists and SERMs (selective estrogen receptor modulators). We discuss: How Lisa's personal family history and scientific background led her to focus on the intersection of women's health, brain aging, and Alzheimer's disease (AD) [2:45]; The long preclinical phase of AD and the emotional burden carried by patients before dementia becomes severe [7:15]; How AD compares to other common forms of dementia: prevalence, pathology, symptoms, diagnostic challenges, and more [10:45]; Why AD disproportionately affects women: how AD is not simply a disease of old age or longevity but a midlife disease in which women develop pathology earlier [16:15]; Menopause as a leading explanation for women's increased Alzheimer's risk, and how advanced braining imaging can detect early changes in the brain [26:15]; How a new method for imaging estrogen receptors in the brain is changing how we think about the menopause transition [35:45]; What estrogen receptor imaging can and cannot tell us about hormone therapy's potential impact on brain health [48:45]; Lisa's studies on the relationship between levels of systemic estrogen and density of estrogen receptors in the brain [58:00]; Why blood estrogen levels poorly reflect brain estrogen signaling, and how tightly regulated brain hormone dynamics complicate our understanding of menstrual-cycle and lifestyle effects [1:02:15]; The CARE Initiative: Lisa's research program looking to slash AD rates in women [1:07:45]; The dramatic difference in AD risk between men and women associated with APOE4 [1:10:45]; What the evidence suggests about menopausal hormone therapy (MHT) and AD risk, and why timing, formulation, and uterine status appear to matter [1:12:00]; How the CARE initiative plans to study MHT and AD risk, within the practical constraints of a three-year research window [1:17:30]; How to think about starting hormone therapy during perimenopause: balancing symptom relief, hormonal variability, and individualized care [1:21:00]; Investigating selective estrogen receptor modulators (SERMs) as a targeted approach to brain health during and after menopause [1:25:00]; Why estrogen became wrongly associated with cancer risk and what the evidence actually shows [1:29:30]; Why better biomarkers are central to advancing women's Alzheimer's research [1:38:30]; Modifiable risk factors for dementia, the limitations of risk models, and questionable conclusions drawn from observational data [1:44:15]; GLP-1 agonists and brain health: exploring potential neuroprotective effects of GLP-1 agonists beyond metabolic benefits [1:49:00]; The importance of lifestyle factors in reducing risk of dementia: practical strategies for women to support brain health [1:53:45]; Why long-term, consistent lifestyle habits are essential for building cognitive resilience and protecting brain health over decades [2:01:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this episode of Barbell Shrugged, Doug Larson is joined by longtime co-host Travis Mash and new co-host Dr. Mike Lane for a return visit from one of the show's most popular guests, Dr. Tommy Wood. Tommy breaks down the core thesis of his new book, The Stimulated Mind (releasing March 24), which uses dementia prevention as the headline but is really about boosting cognition at every stage of life. The crew sets the tone early: brain health is not "old people stuff," it's performance, learning, and resilience, built daily through how you live and how you train. Tommy makes the case that "optimization" only works when it fits real life, and that the brain adapts like the body: sleep, nutrition, and exercise support it, but you still have to "train the brain" with demanding learning and skills. He outlines a practical learning dose-response, roughly 30–90 minutes of deep challenge per session, 2–3 times per week as a sweet spot for consolidation, while acknowledging the power of daily touchpoints for habit formation (Doug's Duolingo streak and the "don't break the chain" approach). From there, they go deep on exercise modalities and cognition: aerobic work and interval training improving hippocampal function (memory), high-intensity work potentially driving brain benefits through lactate → local BDNF, and coordinative/open-skill sports (racket sports, dancing, martial arts) producing outsized brain returns for the same physical strain. The conversation closes with a fast but important run through risk, genetics, and lifestyle: Tommy explains ApoE4 as a risk multiplier that's highly environment-dependent, amplifying bad inputs (inflammation, poor metabolic health) but also amplifying the benefits of doing the basics well. They hit the big nutrition levers for cognition; omega-3s, key B vitamins (methylation), vitamin D, iron, plus polyphenol-rich foods (berries, cocoa, coffee/tea), and squash the common "red wine" rationalization by emphasizing net outcomes (sleep and brain volume matter). Finally, Tommy emphasizes the under-rated keystone: social connection and pro-social behavior, arguing that the Mediterranean "diet" is really a Mediterranean lifestyle, and that isolation can erase many of the benefits of even a perfect nutrition plan. Links: Doug Larson on InstagramCoach Travis Mash on Instagram  

Send us a textMost people assume brain aging is something you deal with later. Or worse, something you can't change at all.Christin Glorioso has spent her career proving that assumption wrong. With MD PhD training, a neuroscience postdoc at MIT, and her work as the founder and CEO of NeuroAge, she studies how the brain ages and how much of that process is actually within our control. The work became personal when she uncovered a genetic risk for Alzheimer's disease and saw the same diagnosis move through her family.Dr. Kevin White sits down with Christin to explore what happens when brain health stops being abstract and becomes something you can measure. They talk through how brain aging often starts much earlier than people realize, why waiting for symptoms is a losing strategy, and how factors like sleep disruption, rising blood pressure, lipid changes, and fitness quietly shape cognitive health years before memory problems appear.In this episode, you'll hear how Christin tested her own brain age, made targeted lifestyle and medical changes, and saw measurable improvements including increased hippocampal volume. They also unpack why genetics are not destiny, how prevention works when it starts early enough, and why clarity can be more empowering than reassurance.“Thinking you're destined for cognitive decline is one of the biggest myths in medicine.”                                                            Christin GloriosoIf you've ever wondered when you should start paying attention to brain health, or assumed cognitive decline was inevitable, this conversation offers a grounded and hopeful reframe rooted in data, agency, and practical action.Learn more about NeuroAge testing at neuroagetx.com, join the app waitlist at waitlist.neuroagetx.com, and follow Christin on Instagram at @neuroage_therapeutics.If you enjoyed this episode, follow The Daily Apple and leave a review. It helps more people find the show. Learn more at www.primehealthassociates.com and follow Dr. Kevin White on Instagram and YouTube at @KevinWhiteMD. Prime Health Associates

Could a decline in "plasmalogens" be a missing link in Alzheimer's and aging? Dr. Peter Meikle reveals why this critical brain lipid drops as we age and the surprising foods that might help restore it.In this interview, we sit down with Dr. Peter Meikle, Head of the Metabolomics Laboratory at the Baker Heart and Diabetes Institute, to explore the critical role of plasmalogens in human health. Plasmalogens are unique phospholipids that act as powerful antioxidants, protecting our cell membranes from oxidative stress. Dr. Meikle explains how plasmalogen levels naturally decline with age and why this drop is strongly associated with Alzheimer's disease, heart disease, and fatty liver.We dive deep into the genetic connection, specifically how the ApoE4 gene impacts these lipids, and discuss the results of mediation analyses that suggest a causal link to neurodegeneration. Finally, Dr. Meikle shares practical advice on how to boost your levels, debating the trade-offs of dietary sources like eggs and red meat versus supplements like krill oil and shark liver oil, and outlines the future of synthetic plasmalogen therapy.

"What's good for the heart is good for the brain."  Can better cholesterol management in midlife actually lower your patient's risk of Alzheimer's disease? In this episode, I'm joined by returning guest Josh Wageman, PhD, PA-C, a clinical lipid specialist who studied cholesterol disturbances in Alzheimer's disease.  Together, we unpack how cholesterol, APOB, APOE4, insulin resistance, and statins intersect with Alzheimer's disease and cognitive decline, and what clinicians can do now to protect brain health long before symptoms appear. Plus, a peek at emerging therapies (including GLP-1 receptor agonists and lipid-centric approaches) and how a metabolic lens is reshaping future Alzheimer's treatment.Resources Mentioned:Josh's New Book117 | What's the Best Diet to Lower Cholesterol?111 | HDL = Good, LDL = Bad? It's Not That Simple.80 | The MIND Diet: What To Eat For Brain HealthAny Questions? Send Me a MessageSupport the showConnect with Colleen:InstagramLinkedInSign up for my FREE Newsletter - Nutrition hot-topics delivered to your inbox each week. Disclaimer: This podcast is a collection of ideas, strategies, and opinions of the author(s). Its goal is to provide useful information on each of the topics shared within. It is not intended to provide medical, health, or professional consultation or to diagnosis-specific weight or feeding challenges. The author(s) advises the reader to always consult with appropriate health, medical, and professional consultants for support for individual children and family situations. The author(s) do not take responsibility for the personal or other risks, loss, or liability incurred as a direct or indirect consequence of the application or use of information provided. All opinions stated in this podcast are my own and do not reflect the opinions of my employer.

There is something incredibly liberating that happens when you realize your genes are not a life sentence. We have all been told that if a gene runs in your family, you're destined to live out the same story. Celiac. MTHFR. Hashimoto's. Breast cancer genes. We're taught to brace ourselves instead of learning how to influence the environment those genes live in. When the gut is overwhelmed, the immune system stays in a reactive state, and in that environment certain genes become more expressive than they would in a balanced body. And as the gut heals and the immune system steadies, those expressions often soften again.When we move through life in the energy of fearing our bodies, or resenting the parts of us that feel complicated or confusing, it creates a disconnect. Not just within us, but within our children. They feel it. They feel the way we brace around certain symptoms. They feel the heaviness we carry when we believe something is wrong with us, or wrong with them. Our energy teaches them what to believe about their own bodies, the world around them, and what is possible or impossible.If your child has a gene variant that society labels as undesirable, the most healing thing you can offer them is not fear. It's acceptance. It's steadiness. It's the belief that their body is not broken. Because when you hold that belief, they learn to hold it too.Your body is not something you need to fear. Your child's body is not something to fix. Every single part of you was designed on purpose. Every one of your gene variants is a page in your story. And when certain genes express, it is an invitation. It is your body communicating with you and bringing you back into alignment so you can show up in your life as the best version of you.. It is your body asking you to come closer, not pull away.When you view your body through this lens, everything shifts. You stop battling yourself. You stop bracing for what might happen. You begin partnering with your body instead of fearing it. And this is where your deepest power lives. In relationship. In understanding. In the environment you create on the inside.Your genes respond to you. They respond to the way you live, the way you nourish yourself, the way you support your gut and your nervous system, the way you speak to yourself, the way you choose to show up every day. And the more safety and nourishment you bring into your life, the more your genes settle into the expression that serves you.This is the freedom of gene expression. This is the empowerment that no lab report can ever take away from you. Thanks for listening! I would love to connect with you ♡ Subscribe to the Nourished Newsletter Explore the Gut Rebalance Kits Visit our FAQ's Follow along on a Instagram Take the free Gut Health Quiz Email us at customercare@onleorganics.com Sending love and wellness from my family yours,xx - Juniper BennettFounder of ōNLē ORGANICS

Alzheimer's disease is something many of us have seen affect our parents or grandparents, and it can feel like one of the most daunting challenges of ageing. But what if the narrative we've been told isn't the whole truth? What if prevention – and even reversal – is possible? Today, I'm delighted to welcome Dr Dale Bredesen to my Feel Better, Live More podcast, a conversation I've been looking forward to for many years. An internationally recognised expert in the mechanisms of neurodegenerative diseases, Dale's career has been guided by a simple idea: that Alzheimer's as we know it is not just preventable, but reversible. His dedicated pursuit of the science that makes this a reality has placed him at the vanguard of neurological research and led to the discoveries that today underlie the ReCODE Protocol™. As well as multiple scientific publications, Dale has written about his findings and research in his first book: ‘The End of Alzheimer's', and his very latest book The Ageless Brain is a fantastic read about the simple things we can all do to improve the health of our brains today and across the duration of our lives. In this powerful conversation, we discuss:    Why Alzheimer's is not one single disease, but the end result of multiple systems in the body becoming imbalanced. The four stages of cognitive decline, and why identifying problems early can be a game-changer for prevention and treatment. The role of genetics, including ApoE4, in dementia risk, and why knowing your genetic status can empower you to take action. How inflammation, toxins and energy deficits all contribute to brain decline – and what we can do to address them.    Real-life case studies of people who have improved, even those in the early stages of dementia. The seven key lifestyle factors that can protect and optimise brain health at any age, from diet and exercise to sleep, stress and detoxification. Dale also shares his vision of a future where cognitive decline is no longer seen as an inevitable part of ageing, but as something we can act on early – much like we already do with heart disease or cancer - and this opens the door to simple, everyday steps we can all take to protect our brains. If you've witnessed Alzheimer's in your family, it's easy to feel powerless. But as Dale explains, there is much we can do to reduce our risk, support brain health and hold onto the connections and memories that matter most. I hope you enjoy listening. Support the podcast and enjoy Ad-Free episodes. Try FREE for 7 days on Apple Podcasts https://apple.co/feelbetterlivemore. For other podcast platforms go to https://fblm.supercast.com.   Thanks to our sponsors: https://drinkag1.com/livemore https://airbnb.co.uk/host https://www.calm.com/livemore https://www.boncharge.com/livemore   Show notes https://drchatterjee.com/592   DISCLAIMER: The content in the podcast and on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

In this episode of The Neuro Experience, I sit down with Dr. Kellyann Niotis—one of the first fellowship-trained preventive neurologists—to reveal how you can protect your brain long before symptoms of Alzheimer's or dementia appear. With Alzheimer's cases expected to triple by 2050, Dr. Niotis explains the difference between dementia types, the real role of genes like ApoE4, and why lifestyle choices may be more powerful than genetics. If you want actionable tools to lower your risk, strengthen your memory, and understand the future of preventive neurology, this conversation delivers science-backed strategies you can start applying today. About Dr. Kellyann Niotis: Dr. Kellyann Niotis is the first fellowship-trained preventive neurologist focused on reducing risk for Alzheimer's, Parkinson's, and Lewy Body Dementia. She launched the nation's first Alzheimer's Prevention Clinic at Weill Cornell and now leads early-detection and brain health research at the Institute for Neurodegenerative Diseases Florida. Her work appears in leading medical journals and has been featured by CNN. *** Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode:TimelineHead to⁠ http://timeline.com/neuro⁠ to get started. BeamVisit ⁠http://shopbeam.com/TNE⁠ and use code TNE at checkout. Jones Road BeautyHead to ⁠http://Jonesroadbeauty.com⁠ and use code NEURO at checkout. After you purchase, they will ask you where you heard about them. PLEASE support our show and tell them our show sent you. NOCDHead to ⁠http://learn.nocd.com/NEURO⁠ and book a free 15 minute call to get started. Eko HealthGo to ⁠http:/ekohealth.com/NEURO ⁠ for up to $50 off, plus a free chest piece cover.  *** I'm Louisa Nicola — clinical neuroscientist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ *** Topics discussed: 00:00 – Introduction 01:25 – Preventative neurology 02:23 – Dementia vs. Alzheimer's & Other Types of Dementia 04:08 – What Is Alzheimer's? 05:26 – Clinical Diagnosis: Imaging & Symptoms 07:07 – How Amyloid Disrupts Neural Communication 09:48 – Genetics vs. Lifestyle: Public Misunderstanding 12:02 – Role of Family History & Genetic Risk 14:04 – The ApoE4 Gene Explained15:07 – ApoE Variants 17:08 – ApoE4 and Lipid Transport in the Brain 18:35 – Immune Response & Infection Susceptibility 20:05 – Hormones: Key Role in Brain Health 21:08 – Genotypes & Risk Multipliers 23:01 – ApoE4 Not Always Deterministic: Population Studies 24:15 – Other Genetic Factors Beyond ApoE 25:13 – Biomarkers: Current Use & Limitations 27:13 – Risks of Self-Testing Biomarkers 28:45 – Why Two-Thirds of Patients Are Women 29:46 – Estrogen, Menopause & Neuroprotection 32:07 – Testosterone & Dementia Risk 35:01 – LDL, ApoB & Brain Health Debate 37:01 – Statins & Dementia: Myths vs. Evidence 39:08 – Fear & Misconceptions Around Cholesterol 41:09 – Lipoprotein(a) & Vascular Dementia Risk 44:39 – Brain Vasculature & Hypertension 49:15 – New Alzheimer's Drugs & Risks 55:32 – Why Rates Keep Rising (Lifestyle & Stress) 58:11 – Early Signs 01:00:23 – Tau Protein, Tangles & Neuronal Damage 01:05:49 – Keto vs. Mediterranean 01:07:14 – Personalization & Preference for Mediterranean Diet Learn more about your ad choices. Visit megaphone.fm/adchoices

Alzheimer's is not inevitable—and it may even be optional. In this groundbreaking episode, you'll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer's researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer's is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance. Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You'll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life. This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You'll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee. You'll Learn: • Why Alzheimer's can begin as early as your 20s and what biomarkers to track • The seven major drivers of Alzheimer's and how to reverse them with biohacking strategies • How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it • The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity • Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s • How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alzheimer's prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer's, Paraquat Parkinson's risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer's, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine Thank you to our sponsors! EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Resources: • Dale's Website: https://www.apollohealthco.com/dr-bredesen/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 2:43 — Personal Story 7:52 — APOE4, Genetics, and Drug Development 11:37 — Pharma, Media, and Pushback 17:13 — Prevention, Stages, and Biomarkers 23:34 — Causes and Mechanisms 30:24 — Parkinson's, Toxins, and Mitochondria 37:17 — Longevity, Biohacking, and Protocols 44:11 — AI, Data, and Future Treatments 54:11 — Case Studies and Success Stories 1:03:00 — Detox, Mold, and Environmental Triggers 1:12:00 — Neuroplasticity and Brain Regeneration 1:20:00 — Hormones, Supplements, and Personalized Hacks 1:29:00 — Cortisol, Addison's, and AI Protocols 1:38:00 — Large-Scale Trials and Global Impact 1:45:00 — Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Dr. Jockers explores the shocking truth about saturated fat—how it can actually lower inflammation, protect your cells, and even reduce your risk of stroke. You'll learn how the right fats support hormone signaling, boost energy, and promote healthy aging.   You'll discover the brain-enhancing power of medium-chain fats that fuel memory, mood, and cognition. These unique fats also spark mitochondrial growth and strengthen immune defenses in ways most people never expect.   But not everyone benefits the same. Dr. Jockers explains who should be cautious with saturated fat, how genetics like the APOE4 gene and sluggish bile flow come into play, and what it means for your long-term health.     In This Episode:  00:00 Introduction to Saturated Fats 03:30 Health Benefits of Saturated Fats 04:07 Understanding Oxidation and Inflammation 06:26 Saturated Fats and Brain Health 07:30 Saturated Fats and Immune System 08:31 Saturated Fats and Hormone Function 11:33 When Saturated Fats Can Be Problematic 13:18 Improving Bile Flow and Liver Health 14:56 Genetic Considerations: APOE4 Gene 16:48 Best Sources of Saturated Fats 20:07 Conclusion and Final Thoughts     Are swollen legs or ankles slowing you down? Discover the power of Lymph System Support by Pure Health Research. Crafted with natural ingredients like dandelion extract, burdock root, and bromelain, this formula unclogs your lymphatic system, reducing swelling and supporting a healthy inflammatory response.   As a special offer, try Lymph System Support risk-free today and receive a complimentary bottle of curcumin extract. Visit GetLymphHelp.com/jockers to claim yours now. Say hello to renewed vitality and goodbye to discomfort!   Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com/DRJ.     “Chronic disease starts with oxidation—saturated fat helps shut it down.”  ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   Resources: GetLymphHelp.com/jockers Visit https://renewyourhair.com/drj   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Rhonda Patrick, Ph.D. (@foundmyfitness) is a biomedical scientist and the founder of FoundMyFitness, a platform dedicated to delivering rigorous, evidence-based insights on improving healthspan and mitigating age-related diseases.Sponsors:Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine and other supplements: https://livemomentous.com/tim (code TIM for up to 35% off)David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim (Buy 4 cartons, get the 5th free.)Monarch Money track, budget, plan, and do more with your money: MonarchMoney.com/Tim (50% off your first year at monarchmoney.com with code TIM)Timestamps:[00:00:00] Start.[00:04:54] Dealing with aging parents and other topics on the table.[00:10:43] How a common multivitamin helps reverse cognitive and memory aging.[00:12:04] The importance of supplementation — especially as we age.[00:13:10] Effectively supplementing with omega-3 fish oil to counter APOE4 and Alzheimer's risks.[00:16:50] The CoQ10 and omega-3 protocol that has helped Rhonda's father manage Parkinson's symptoms for nearly a decade.[00:19:28] Sulforaphane: a potent NRF2 activator with an unexpected benefit for Rhonda's mother's tremors.[00:25:34] How Rhonda convinced her mom to start CrossFit and the power of community-based, senior-focused fitness.[00:26:52] The earlier the intervention, the better the outcomes.[00:32:25] Intermittent fasting vs. extended fasting and my own results.[00:44:31] Does fasting destroy muscle mass? Debunking the catabolism fear and understanding the crucial role of the re-feeding phase.[00:57:24] "Dirty" fasting: what really happens to autophagy and metabolic benefits when you add a splash of cream or MCT oil to your coffee?[01:00:44] VO2 max: the one metric that may predict lifespan more accurately than anything else, and how we work to improve it.[01:12:07] How a two-year exercise program reversed heart aging by 20 years in previously sedentary, middle-aged adults.[01:16:18] Lactate isn't the enemy: how vigorous exercise creates a superfuel that protects and grows the brain.[01:20:30] The optimal sauna protocol (temperature and frequency) for slashing dementia risk by 66%.[01:29:17] If you're human, you'll find a use for curcumin.[01:30:43] Creatine for cognition: moving beyond the gym with a powerful, science-backed tool for focus and combating sleep deprivation.[01:42:41] Still vitamin D deficient despite taking supplements? Here's the critical cofactor you're probably missing.[01:53:52] Shocking sources of microplastics in our daily lives, including chewing gum and teabags.[02:04:10] The uncomfortable truth about "moderate" alcohol consumption, cancer risk, and why the "sick quitter" hypothesis makes most older studies unreliable.[02:17:03] The ups and downs of ketamine and psilocybin on cognition and longevity.[02:24:19] Parting thoughts and where to find more from Rhonda.*Show notes for this episode: https://tim.blog/2025/07/24/dr-rhonda-patrick/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.