Podcasts about nrf2

Full show notes: https://bengreenfieldlife.com/marapodcast In this episode, you will hear the origin story of Mara Labs, a company built around sulforaphane, the active compound found in broccoli that has been studied across thousands of papers covering almost every major chronic disease, and why most people are not actually getting it from their broccoli supplements. You will discover why the way your broccoli supplement is made determines whether any of it reaches your cells at all, what dose of the active compound moves the needle on inflammation, detox, and cellular defense, and how a single capsule compares to eating five pounds of adult broccoli a day. You will also hear something that has not been discussed publicly before: a pilot study showing that this same compound can trigger your cells to release microplastics, those synthetic particles now found in human blood, lungs, and breast tissue, and push them out through your digestive system. David Roberts is the co-founder and managing partner of Mara Labs. After his wife Mara was diagnosed with breast cancer in 2012 and passed away in 2017, David channeled his experience into building a supplement company grounded in clinical science rather than ingredient trends. Dr. John Gildea is Chief Science Officer and co-founder, with a PhD in molecular biology and over 20 years studying the Nrf2 pathway at the University of Virginia. Author of more than 60 peer-reviewed publications, he developed the stabilization method that made shelf-stable sulforaphane possible and has since led research on sulforaphane's effects on microplastics and cancer stem cells. For the next week, save 25% off all Mara Labs products using code BEN at bengreenfieldlife.com/maralabs. After June 20th, the code returns to the standard 15% off. Episode Sponsors: Fatty15: Fatty15 is on a mission to optimize your C15:0 levels and help you live healthier, longer. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/BEN and using code BEN at checkout. Hiya: Give your kids the full-body nourishment they need to grow into healthy adults. I’ve secured a special deal with Hiya on their best-selling children's vitamin—get 50% off your first order today! To claim this deal, you must go to hiyahealth.com/BEN (it is not available on their regular website). Young Goose: To experience the transformative power of Young Goose's cutting-edge skincare products, visit younggoose.com and use code BGF10 at checkout to enjoy a 10% discount on your order. Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20–25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. Pendulum: Metabolic Daily is a powerful multi-strain probiotic that improves your metabolism, reduces sugar cravings, breaks down carbs more efficiently, and sustains your energy levels. You’ll receive 20% off your first month of any Pendulum probiotic with code BEN at PendulumLife.com.See omnystudio.com/listener for privacy information.

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

On this episode of The Jon Gordon Podcast, I sit down with Dr. John Gildea—a pioneering researcher on gut health, soil and healing.   Our conversation goes deeper than science, tracing Dr. Gildea's unlikely journey from the lab at the University of Virginia to becoming an integral voice in the movement to restore health through soil-based nutrition. Dr. Gildea shares how his partnership with Dr. Zach Bush set him on the path to groundbreaking discoveries in gut health. Together, we discuss the debilitating personal battle I faced with gut issues for over a decade, and how his research and soil-derived formula became the catalyst for my healing—a story echoed by countless others. Throughout the episode, we unpack the science behind gut barriers, explain how environmental toxins like glyphosate disrupt our health, and reveal why reconnecting to nature's intelligence can help the body heal itself from the inside out. Dr. Gildea demystifies the complex processes at play, explaining the pivotal role of NRF2 and the remarkable results he's witnessed firsthand—even in the most challenging cases. Whether you're struggling with chronic gut issues, curious about the root causes of inflammation, or seeking hope for true health, this conversation is a testament to breakthrough science and the power of nature's solutions. Tune in for an inspiring reminder that healing is possible and that there are answers waiting for those who refuse to give up. To get the ION product that healed my gut and changed my life go here: Gut Support Skin Support Pet Support ION Homepage SAVE 35% ON ION PRODUCTS NOW - SPECIAL OFFER Visit any of the special ION product links above and enter JONGORDON35 at checkout to save 35%   About Dr. Gildea: Dr. John Gildea Chief Science Advisor | ION* Dr. John Gildea is a Johns Hopkins-trained PhD and cellular biologist with more than 60 peer-reviewed publications across 20+ NIH-funded studies. His research career spans early HIV diagnostics, oncology, and foundational work in kidney physiology, with a particular focus on human-derived cell models to study nutrient absorption, cellular signaling, and the body's mechanisms for maintaining internal balance. As Chief Science Advisor at ION*, Dr. Gildea applies that depth of expertise to questions at the intersection of gut barrier integrity, environmental stress, and cellular response — helping translate rigorous science into meaningful insights for human health.   Here's a few additional resources for you… Do you feel called to share your story with the world? Check out Gordon Publishing  Follow me on Instagram: @JonGordon11 Every week, I send out a free Positive Tip newsletter via email. It's advice for your life, work and team. You can sign up now here and catch up on past newsletters. Ready to lead with greater clarity, confidence, and purpose? The Certified Positive Leader Program is for anyone who wants to grow as a leader from the inside out. It's a self-paced experience built around my most impactful leadership principles with tools you can apply right away to improve your mindset, relationships, and results. You'll discover what it really means to lead with positivity… and how to do it every day. Learn more here! Do you feel called to do more? Would you like to impact more people as a leader, writer, speaker, coach and trainer? Get Jon Gordon Certified if you want to be mentored by me and my team to teach my proven frameworks principles, and programs for businesses, sports, education, healthcare!

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body.. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time. They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time. You'll Learn: Why microplastics accumulate inside lysosomes and what sulforaphane does to release them How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin What an in-house study revealed about how and where microplastics actually leave the body How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch How sulforaphane boosts BDNF and neuroplasticity at the cellular level What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food Thank you to our sponsors! - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - Timeline | Go to timeline.com/dave and you'll get an additional 20% off your first month - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. John Gildea, David Roberts, Mara Labs, BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine, BerbaLite, ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox Resources: • For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:55 – Intro & Context 4:48 – Microplastics & Sulforaphane 12:39 – Broccoli Sprouts Formulation 15:20 – Lab Origin Story 26:01 – Reducing Toxin Exposure 37:06 – Estrogen, Hormones & Berberine 52:46 – Autism, ADHD & Brain Health 59:01 – Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the future of medicine is hiding beneath the ocean's surface?In this fascinating episode, I sit down with one of the most intriguing scientists I've ever encountered: Dr. Hendrik Luesch.Dr. Hendrik is a professor of medicinal chemistry at the University of Florida, director of UF's Center for Natural Products Drug Discovery and Development, and author of more than 200 peer-reviewed scientific papers. But what makes his work truly remarkable is where it begins — not in a traditional laboratory, but in the ocean itself.Dr. Luesch reveals how cyanobacteria, seaweed, and ocean organisms may hold powerful clues for the future of medicine, healthy aging, inflammation support, and longevity.You'll also learn the science behind NRF2 activation, glutathione production, immune health, mitochondrial support, and how compounds found in sea lettuce inspired the ingredient Algevity Factor® featured in one of my latest supplements: Gundry MD Longevitine Plus.On this episode, you'll learn: Why the ocean may contain some of the most promising untapped sources of future medicines (04:00)Dr. Hendrik's incredible stories on scuba diving for “chemical gold” in Hawaii and Florida (04:40)All about one of the most important organisms for studying healthy aging and longevity (05:20)How marine organisms create compounds that may inspire future therapies (05:46)The incredible story behind marine compounds that helped inspire FDA-approved anti-cancer drugs (07:10)How sea lettuce became the inspiration behind one of my newest supplements (18:10)What NRF2 actually is — and why it may be more powerful than simply taking antioxidants directly (19:25)How marine compounds may help support immune and mitochondrial health (22:50)For the full episode transcript and show notes: https://drgundry.com/is-seaweed-good-for-youThank you to our sponsors! Check them out: Shop my new air filter, Homekind Total Air! Use code CLEANAIR for 10% off. For all your blue-light and EMF-blocking accessories, go to boncharge.com/GUNDRY and use the coupon code GUNDRY to save 15% off your entire order.Transform your sleep experience with Cozy Earth bedding. Go to cozyearth.com/gundry for 20% off.Get a quote today at Progressive.com.Go to timelinenutrition.com/GUNDRY to get 10% off any Timeline Nutrition product.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of Wholistic Living, we dive into the powerful connection between myrosinase, gut health, eczema, inflammation, detoxification, and the microbiome. Learn why cruciferous vegetables like broccoli, kale, arugula, cabbage, and broccoli sprouts may not provide their full benefits if the enzyme myrosinase is lacking or destroyed through cooking and poor gut health. We explore how low myrosinase activity on stool testing may reflect dysbiosis, poor microbial diversity, chronic inflammation, mold exposure, antibiotic damage, sluggish bile flow, and impaired detoxification pathways. Discover how this impacts sulforaphane production, NRF2 activation, glutathione, histamine intolerance, hormone balance, liver detoxification, autoimmune conditions, eczema, psoriasis, and skin inflammation. You'll also learn practical ways to naturally increase sulforaphane activation, preserve myrosinase in foods, support gut bacteria involved in glucosinolate metabolism, and improve detoxification through nutrition and lifestyle.Topics covered:What myrosinase is and why it mattersLow myrosinase on stool tests explainedSulforaphane, NRF2, and glutathioneEczema, psoriasis, and chronic inflammationGut dysbiosis and detoxificationMold illness and histamine intoleranceHow cooking affects broccoli and cruciferous vegetablesBroccoli sprouts, mustard seed powder, and sulfur-rich foodsHormone balance, estrogen detox, and liver healthIf you struggle with eczema, skin issues, autoimmune symptoms, histamine reactions, poor detoxification, gut problems, or chronic inflammation, this episode is packed with science-backed holistic insights you do not want to miss.Equip Grass fed protein: www.equipfoods.com/MARLAWork with me: https://holisticspring.com/contactInstagram: www.instagram.com/wholistichomeopath

Text Dr. Lenz any feedback or questions Why I Don't Recommend AG1: A Cheaper, Higher-Fiber Whole-Food Smoothie AlternativeDoctor Michael Lenz critiques AG1/greens powders as expensive, marketing-driven products ($79 for 30 servings) that rely on proprietary blends with unclear dosing, may reduce benefits compared with whole-food “food matrix” nutrition, and provide too little fiber (2 g per scoop). He argues real health comes from a whole-food, plant-based diet that can reduce inflammation and risk of chronic diseases, and offers a daily smoothie formula as a transparent, affordable alternative: water, two cups leafy greens, one cup broccoli sprouts (sulforaphane/NRF2), frozen berries and bananas (polyphenols, potassium), turmeric plus black pepper (curcumin + piperine), flax or chia (fiber/omega-3s), and lemon. He advises gradually increasing fiber to avoid GI distress, compares the smoothie (15–20 g fiber) plus overnight oats breakfast (~40 g fiber) to a common high-calorie, high-saturated-fat, low-fiber American breakfast, and urges viewers to save money and try whole foods for a week.00:00 Why I Skip AG100:43 Marketing vs Reality01:27 Three Big Problems01:47 Proprietary Blend Trap02:55 Whole Foods Absorption03:37 The Fiber Dealbreaker04:23 Real Food Solution05:20 Anti Inflammatory Smoothie05:29 Smoothie Ingredient Formula05:56 Sprouts and Sulforaphane06:31 Berries Bananas Turmeric08:16 Fiber Ramp Up Warning09:35 Cost and Fiber Comparison10:49 Breakfast vs American Meal12:24 Final Takeaways and Challenge Support the showWhen I started this podcast and YouTube Channel—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That's why I created this space: to offer education, validation, and hope.  If you've been told fibromyalgia “isn't real” or that it's “all in your head,” know this—I see you. I believe you. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you'll find trusted, evidence-based insights here, drawn from my 29+ years as an MD.Please remember to talk with your doctor about your symptoms and care. This content doesn't replace per...

Academic Summary: For decades, clinical trials on silymarin (milk thistle) yielded inconsistent results because scientists were looking in the wrong place—measuring standard blood plasma and expecting high systemic levels of the free extract. A groundbreaking new framework reframes this entirely, revealing that low blood levels aren't a clinical failure, but proof of a highly targeted "bile-first" delivery system. Rather than flooding the general bloodstream, new discoveries show silymarin is rapidly converted into phase II conjugates that travel directly to the gut-liver interface. There, localized enzymatic hotspots trigger transient "microbursts," reactivating the compounds to edit inflammation, boost NRF2 antioxidant defenses, and trigger deep cellular recycling (autophagy) exactly where the liver needs it most.#MedicalBreakthrough #SilymarinScience #FattyLiver #Pharmacokinetics #LiverRepair #RalphTurchiano #TheCatalystFormal Citation: Pérez de la Lastra JM, Curieses Andrés CM, Bustamante Munguira E, Andrés Juan C, Pérez Lebeña E. Silymarin as a Redox-Signalling and Proteostasis Modulator. Nutraceuticals. 2026; 6:25. doi:10.3390/nutraceuticals6020025.

Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it.

Today, I'm joined by David Roberts and Dr. John Gildea, two passionate researchers whose work sits at the cutting edge of environmental health and longevity science. In this episode, we dive deep into the catalyst for developing a stabilized sulforaphane supplement—something born out of both necessity and relentless curiosity. David opens up about how environmental toxicity stopped being theoretical for him, and Dr. Gildea brings a wealth of clinical insight into why supporting our detox pathways could be a game-changer for chronic disease prevention. Offer: Get 25% off stabilized sulforaphane products for a limited time at mara-labs.com/NAT with code NAT (offer ends April 7th 2026; 15% off thereafter).   Episode Timestamps: Welcome and podcast intro ... 00:00:00 When toxins became personal: cancer & environment ... 00:04:54 Practical detox: household and lifestyle changes ... 00:06:12 Sulforaphane's effect on inflammation and daily function ...00:07:07 Finding health solutions outside conventional medicine ... 00:14:44 Cancer diagnosis prompts sulforaphane stabilization ... 00:18:17 NRF2: master regulator in aging, skin, and detox ... 00:24:16 Sulforaphane, curcumin, and inflammation ... 00:25:11 Supplement confusion: sulforaphane vs. glucoraphanin ... 00:31:10 Food as medicine and practical dosing ... 00:34:51 Microplastics: exposure, health risks, and impacts ... 00:35:31 Detox routes and microplastics research ... 00:47:04 Glyphosate, NRF2 suppression, and gut barriers ... 00:52:54 Sulforaphane boosts detox and protects against pollution ... 00:59:13 GLP-1s, muscle loss risk, and supplement alternatives ... 01:00:08 Berberine: sleep, glucose, and microbiome effects ... 01:06:12 Synergies, future research, and sulforaphane limits ... 01:10:32 Sprouts, seeds, and potency of broccoli compounds ... 01:16:17   Our Amazing Sponsors: Vitali SkinCare - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.   Tro Zzz by Troscriptions – a fast-acting, customizable sleep formula designed to quiet racing thoughts and support deeper, more restorative sleep using a powerful blend of GABA-supporting compounds, cannabinoids, and sleep-promoting ingredients. Head to troscriptions.com, use code NAT10, and get 10% off.   Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Dr. Bill Lawrence Episode

This week's stories: *SNL Roasts the MAHA Movement Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of. Sources: -https://www.nbc.com/saturday-night-live -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ *Pistachios Are a Stealth Longevity Stack New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested — hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight. Sources: -https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/ -https://www.instagram.com/p/DViqesBDOZQ/ *40 Million People Are Using ChatGPT as Their Doctor Industry estimates put daily ChatGPT health queries at roughly 40 million users — making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned. Sources: -https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ *Your Microbiome Is a City — and Architecture Matters New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not species. Sources: -https://phys.org/news/2026-01-hidden-microbial-communities-health-space.html -https://astrobiology.com/2026/03/rethinking-the-microbial-future-of-space-travel.html *Colon Cancer Is Now the Leading Cause of Cancer Death Under 50 This is no longer a retirement problem. Dave breaks down the four drivers behind the spike — and why your gut health protocols are now frontline cancer prevention. Sources: -https://pubmed.ncbi.nlm.nih.gov/41754195/ -https://www.washingtonpost.com/wellness/2026/03/03/muscle-strength-longevity-study/ *Measles Is Back — and the Math Is Unambiguous Over 1,300 confirmed cases across 31 states in 2026 alone, with the US at risk of losing its measles elimination status for the first time since 2000. Dave addresses the "natural immunity" argument directly — and doesn't pull punches. Sources: -https://www.cdc.gov/measles/cases-outbreaks.html -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune resilience, gut health, microbiome optimization, cancer prevention, and how to use AI tools safely. Host Dave Asprey connects emerging science, cultural shifts, and real epidemiological data into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: MAHA movement biohacking, SNL vaccine sketch, RFK health satire, pistachios polyphenols longevity, pistachio Nrf2 AMPK, ChatGPT health advice AI, AI primary care risks, gut microbiome biofilm architecture, colon cancer under 50, colorectal cancer young adults, colon cancer prevention diet, measles outbreak 2026, measles elimination status, natural immunity measles risk, immune amnesia measles, biohacking news, longevity research 2026 Thank you to our sponsors! - Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap- The One Device | Use code DAVE for $10 off at theonedevice.com/dave Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:41 – SNL Roasts the MAHA Movement 03:20 – Pistachios and Longevity 04:37 – AI as Your Health Advisor 06:12 – Gut Biofilms and Microbiome Architecture 07:44 – Colon Cancer in Young People 09:23 – The Measles Comeback See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

341: Today we're talking about nature's Ozempic, the missing nutrient that can help you detox from microplastic and glyphosate, and if you are still suffering from long COVID or know someone who is, we've got answers for you as well! I'm joined by two guests today, John and David from Mara Labs as they share how their bio-available supplements were created from a pain-to-purpose mission after David's late wife passed from breast cancer and now it's David's mission to spread the word on his discovery of Sulforaphane, Berberine, and what they can do together to help detox, build the gut lining, and strengthen our cells for longevity, weight management, and overall health.  → Check Out https://mara-labs.com & Use Code: DIGEST at checkout for 25% until 3/25/2026   Topics Discussed: → Detoxing from microplastics & glyphosate → Leaky gut fixes → What is sulforaphane? → What is berberine?  → How to lower glucose levels & mimic fasting → How to get into ketosis in 4 hours! → How to block fat cells from forming in your body → How to keep muscle on and still lose weight  → Increase BDNF As always, if you have any questions for the show please email us at digestthispod@gmail.com. And if you like this show, please share it, rate it, review it and subscribe to it on your favorite podcast app.  Sponsored By:  → Check Out https://mara-labs.com & Use Code: DIGEST at checkout for 25% until 3/25/2026   Timestamps: → 00:00:00 - Introduction → 00:01:56 - Meet John & David → 00:04:24 - Broccoli, digestive issues, & sulforaphane → 00:06:49 - Detox pathways → 00:08:45 - NRF2 → 00:11:42 - Sulforaphane impacts → 00:12:38 - Toxin elimination & microplastics → 00:18:39 - Capsule creation → 00:19:38 - Glyphosate → 00:23:51 - Leaky gut → 00:27:51 - Joint inflammation → 00:30:02 - Fasting + insulin resistance → 00:34:21 - Long COVID → 00:39:06 - Results → 00:42:33 - “Nature's Ozempic” → 00:46:17 - Myostatin (GDF-8) → 00:49:42 - Berberine + fat absorption → 00:52:31 - Supplement stacking → 00:55:50 - Nutrition & exercise Further Listening:  → Ways To Help Detox From Heavy Metals | BOK Check Out Mara Labs:  → Check Out https://mara-labs.com & Use Code: DIGEST at checkout for 25% until 3/25/2026   Check Out Bethany: → Bethany's Instagram: @lilsipper → YouTube → Bethany's Website → Discounts & My Favorite Products → My Digestive Support Protein Powder → Gut Reset Book  → Get my Newsletters (Friday Finds) Learn more about your ad choices. Visit megaphone.fm/adchoices

In this engaging live episode of Ask the Doctor, host Dr. Michael Lange of the Lange Eye Institute in The Villages, Florida, welcomes listeners to call in with vision, eye care, and nutrition questions at 877-969-8600. A board-certified optometric physician and certified nutritional specialist, Dr. Lange shares his expertise on common eye issues: a caller discusses occasional flashes and long-standing floaters, leading to advice on vitreous changes, retinal tear risks, the value of dilated exams with OptoMap imaging for early detection, and protective nutrition like colorful fruits/veggies and sunglasses. Another addresses severe nighttime glare and halos from headlights (despite glaucoma drops), with insights on emerging cataracts, dry eye management using hyaluronic acid drops like Oasis Tears, windshield/glasses cleanliness, and potential prescription tweaks. The show highlights men's health strategies, emphasizing broccoli sprouts (rich in sulforaphane for prostate protection and better testosterone-estrogen balance via the NRF2 pathway), pomegranate for urolithin A and testosterone support, tomato products for PSA reduction, and high-quality non-denatured grass-fed whey protein (like Fortify Super Protein) to boost glutathione, immunity, muscle building, and overall longevity. Dr. Lange discusses omega-3s (in re-esterified triglyceride form) for lowering aggressive prostate cancer risk, reducing inflammation, and supporting dry eye/eye health. He promotes his evidence-based Fortify Vitamins line (fortify.com or F-O-R-T-I-F-I-E-Y-E.com), including Super Protein (New Zealand grass-fed, no price hikes amid shortages), upcoming Fit Meal with organic broccoli sprouts, whey, and Pomella, plus Super Omega for heart, joint, brain, and eye benefits. Additional highlights include the recent Mardi Gras Festival success at the Lange Eye Institute, exclusive drive lenses for improved night vision, Meta/Oakley smart glasses (and iDaptics for low vision), the power of annual dilated exams for detecting silent conditions like high blood pressure or diabetes, and motivational stories of health transformations through nutrition, exercise, and weight management. Sponsored by the Lange Eye Institute (352-753-4014) and Fortify Vitamins (866-503-9746), with more at drmichaellange.com and YouTube archives. #AskTheDoctor #EyeHealth #Nutrition #FortifyVitamins #ProstateHealth #MensHealth #RetinaCare #DryEye #WheyProtein #Omega3 #LangeEyeInstitute #VisionWellness #TestosteroneBoost #PreventiveHealth #DrMichaelLangeSupport the show: https://www.drmichaellange.com/category/ask-the-doctor/See omnystudio.com/listener for privacy information.

Episodio completo aquí: https://youtu.be/3jOy_X4hIwANathaly Marcus, su historia: De un diagnóstico imposible a ayudar a sanar a miles de personasPor primera vez, Nathaly abre su corazón para compartir su historia, marcada por un “no se puede hacer más” y por ser una madre de 25 años que buscó todas las alternativas para sacar adelante a sus hijas prematuras. ❤️‍

Welcome to "Thriving in Midlife" The Women's Guide to Wellness, Longevity & Hormones After 40. This is your trusted space to cut through the noise, ditch the overwhelm, and finally feel extraordinary in your body, mind, and life. Are you ready to stop pushing through life and start living it with intention, energy, and ease? Then let's get started. I'm your host, Kellie Lupsha, a high-performance health coach, who is delighted to be your guide to vitality.In this episode, Dr. Heidi and I are breaking down something a lot of people get wrong about peptides. We talk about why they don't work the same for everyone, what your body actually needs to respond, and how to set yourself up so that the results you want aren't just a shot in the dark. If you've ever felt frustrated with expensive protocols, confusing advice, or “miracle” fixes that don't deliver, this episode is for you.Key Highlights:➡️ What peptides really are and why thinking of them as signals instead of magic fixes changes everything.➡️Why two people taking the exact same peptide can experience completely different results.➡️How your gut microbiome controls whether peptides can even communicate with your cells.➡️The surprising ways inflammation can block your body from responding to peptides.➡️The role of NRF2, the cellular “master switch,” in creating an environment your body can actually heal in.➡️The order used to set the foundation before introducing peptides for lasting results.➡️What "cell safety" really means and why your cells might be stuck in constant fight-or-flight mode without you even realizing it.➡️The subtle, but powerful, changes women notice when their body finally starts working with them.Key Takeaways:“Two women can take the same peptide… One feels energized, stronger, clear-headed, younger in her body. The other feels… nothing.” -Kellie Lupsha"The microbiome is the gatekeeper of our health... it will be on guard and help those peptides, those signals to be absorbed, interpreted, utilized, optimally."- Dr. Heidi*TAKE THE FREE ~ DISCOVER YOUR MIDLIFE HEALTH BLUEPRINT*****>>> Click Here

Sponsored By: → Mara Labs | For the next week, Heal Thy Self listeners can get an exclusive 25% off all Mara Labs products. Go to mara-labs.com/DRG and use code DRG at checkout. → My one stop shop for quality supplements: https://theswellscore.com/pages/drg Episode Description What if the supplements you're taking aren't doing anything because your body can't actually absorb them? David Roberts and Dr. John Gilday spent years developing Mara Labs after David's wife Mara was diagnosed with breast cancer and they discovered the compound that could help her, sulforaphane from broccoli, didn't exist in stable, absorbable form anywhere. They grew broccoli sprouts for ten families while Dr. Gilday obsessed over stabilizing the molecule. When he finally cracked it, Mara pushed them to share it with the world before she passed away. This episode reveals why most broccoli supplements are essentially worthless, how microplastics are jamming up your cellular detox systems, and why estrogen itself isn't the enemy, but its metabolism might be. You'll learn why berberine outperformed Valium as a sleep aid in studies, how eating late with low insulin production leaves glucose sitting in your blood all night, and why Ozempic's weight loss can be up to 40% muscle. Discover: • The broccoli supplement truth: why 95% of products contain only the precursor molecule that your stomach acid destroys before it can work • The microplastics mechanism: how plastic particles fill up your cellular "drains," blocking the lysosome from clearing waste and creating hormonal noise • The estrogen metabolism shift: why estrogen is protective until it converts to quinones that can make DNA breaks in your genome • The sulforaphane detox pathway: how one compound turns on Nrf2 to activate every cell's built-in detoxification system • The berberine absorption problem: why standard berberine is nearly impossible to dissolve and ends up disrupting your gut microbiome instead of entering your bloodstream • The GLP-1 difference: why natural berberine-induced satiety works without slowing gut motility the way Ozempic does Find Dr. John Gilday & David Roberts: Website: https://mara-labs.com/ Instagram: https://www.instagram.com/themaralabs  Timestamps: 0:00 - Why most hormonal supplements don't work  1:46 - Hot Seat: Biggest detox mistakes and the NRF2 master switch  3:20 - Is berberine nature's Ozempic?  7:18 - Claire's one-month transformation with sulforaphane  9:21 - How Mara Labs was born from a breast cancer diagnosis  17:00 - Microplastics: the forest fire in your body  24:18 - The estrogen truth: it's not the enemy, the metabolism is  35:04 - Why your matcha works better with sulforaphane  39:17 - Berberine, Ozempic, and fasting in a pill  52:12 - The 40% muscle loss problem with Ozempic (and how to prevent it)

What if the biggest metabolism disruptor today is not carbs or calories, but the toxic load you cannot see? In this episode of the Metabolic Freedom Podcast, Ben Azadi sits down with Mara Labs co-founders David Roberts and Dr. John Gildea for a deep dive into microplastics, detox pathways, and the science of sulforaphane. They break down how microplastics and the chemicals that leach from plastics can interfere with cellular function, including lysosomes, autophagy, inflammation, and hormone signaling. You will learn why sulforaphane is known for activating Nrf2, what that means for detox and repair genes, and why the conversation around metabolic health is also a conversation about toxin exposure. They also discuss berberine as a tool for metabolic flexibility, blood sugar support, ketosis, and even sleep, plus new product innovations like BarkElite for dogs. If you want practical strategies backed by research and real-world testing, this one is packed. Key Topics Covered Why microplastics are everywhere and why that matters for metabolism and longevity How microplastics may interfere with lysosomes, autophagy, and cellular cleanup What sulforaphane is and how it activates the Nrf2 pathway Phase 1, 2, and 3 detox explained in plain English Why inflammation is often the real root issue behind stubborn fat loss Berberine, AMPK, GLP-1 signaling, and metabolic flexibility Why late-night eating can wreck sleep and HRV The dog angle: joint support, inflammation, and BarkElite Coupon and Discount  Browse all products featured in this episode : http://www.benazadi.com/mara Mara Labs discount code: FREEDOM 25% off from January 19, 2026 through January 26, 2026 After January 26, 2026: code still works for 15% off Follow Ben Azadi

Michelle Skaff shares how one "cellular biohack" pulled her out of chronic pain, and why she believes oxidative stress is the quiet root of aging, inflammation, and so many chronic issues.  We talk antioxidant enzymes in plain English, why most supplements don't solve oxidative stress at the source, and how community + purpose can be as health-changing as any protocol. WE TALK ABOUT:  04:40 - What NRF2 is and how it helps reduce oxidative stress at the cellular level 10:10 - Understanding SOD (superoxide dismutase) and why antioxidant enzymes matter for aging 12:35 - Explaining oxidative stress with the "apple browning" analogy 15:35 - Why the same intervention works differently at 20 vs 80 17:40 - Using the "cellular traffic lights" framework (NRF2, mitochondria, NAD) 20:30 - Connecting oxidative stress to inflammation and aging hallmarks 28:30 - Debunking the "it's just aging" myth behind joint pain 31:35 - Building a simple good/better/best starting stack for inflammation + joints 37:10 - Testing gut health and why Tiny Health stood out 42:35 - Why community and purpose are emerging longevity tools SPONSORS: Join me in Costa Rica for Optimize Her, a 5-night luxury women's retreat in Costa Rica with yoga, healing rituals, and biohacking workshops—only 12 spots available. RESOURCES: The Only Non-Toxic Baby Registry Guide You'll Ever Need — and It's Free Explore my luxury retreats and wellness events for women. Shop my faves: Check out my Amazon storefront for wellness essentials. Michelle Skaff's Instagram LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

In this episode of The Eric Bach Show, Eric breaks down seven specific foods that make losing stubborn belly and visceral fat easier—not by “magic,” but by improving insulin sensitivity, metabolism, gut health, inflammation, and hormone balance. You'll learn how to build meals that keep you full, support longevity, and help you look great naked… without starving yourself or living in the gym. Why the same foods that help you get leaner also protect your brain, mitochondria, DNA, and cardiovascular system as you age. The 7 Foods Eric Breaks DownCoffeeBoosts metabolic rate (roughly 3–11% in studies).Increases fat oxidation during exercise and can blunt appetite earlier in the day.Loaded with polyphenols like chlorogenic acid that support liver health, reduce oxidative stress, and may lower risk of neurodegenerative disease—as long as you're not turning it into a 500-calorie dessert drink. Lean Beef or Bison (93–95% lean)High-protein, nutrient-dense source with iron, zinc, B12, creatine, and some omega-3s (especially in grass-fed and bison).Higher protein = more thermogenesis, more satiety, better lean-mass retention in a deficit.CLA and omega-3s are linked to reductions in visceral fat and improved metabolic health. Wild BlueberriesImprove insulin sensitivity and help stabilize blood sugar, reducing cravings.High in fiber plus powerhouse antioxidants and polyphenols (anthocyanins) that support brain health, BDNF, and mitochondrial protection.Wild varieties can have 2–3x the antioxidant load of regular blueberries. Broccoli (and other crucifers)Ultra high volume, low-calorie, fiber-rich—great for appetite control and blood sugar stability.Rich in sulforaphane, which activates NRF2 (your body's “master antioxidant switch”) to support detoxification, lower inflammation, and protect DNA from damage. Greek Yogurt (2% or Non-Fat)High in protein to preserve muscle and support metabolism during fat loss.Probiotics support gut health, digestion, inflammation, and immune function.Fermented dairy is linked to better microbiome diversity and improved longevity markersLeafy Greens (Spinach, Kale, Arugula, Romaine, etc.)Low-calorie, high-volume, packed with folate, vitamin K, magnesium, nitrates, and antioxidants.Support insulin sensitivity, stress management, cardiovascular health, and nitric oxide (better blood flow, performance… and erections).Simple habit: a “big-ass salad” at dinner most nights. Wild-Caught SalmonElite combo of high-quality protein and omega-3 fats (EPA + DHA).Helps improve insulin sensitivity, lower systemic inflammation, and reduce cardiovascular risk by ~25–35% in some research.Supports brain function, mood, joint health, and telomere protection—huge for longevity and preserving leanness as you age. Big TakeawaysYou don't need “fat-burning foods”—you need fat-loss friendly foods that make a calorie deficit sustainable.Focus on foods that either had a face or came from the ground: protein + fiber + micronutrients beat pills, potions, and powders.Start by consistently adding 2–3 of these foods into your daily rotation, then build from there. Who This Episode Is ForAnyone struggling with stubborn belly fat despite “eating

Welcome back to our weekend Cabral HouseCall shows!   This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track!   Check out today's questions:    Stephen: Hi Dr. Cabral, I wanted to get your thoughts on a supplement called Protandim — a product marketed to reduce oxidative stress by activating Nrf2, support cellular repair, and promote detoxification and gene regulation. The company claims it's backed by dozens of peer-reviewed studies, but most of the research has been done in animals or cell cultures, and the few human studies show mixed results. Online opinions seem polarized — some call it a marketing gimmick, while others swear by it — so it's been difficult to find balanced, evidence-based perspectives. I'd love to hear your assessment — whether you've had any experience with it in your practice, what results (if any) you've observed, and whether you'd consider it a science-supported supplement worth considering.              Sarah: Hey doc! I've been rebounding/vibration plate/dry brushing consistently for over 2 years now. I also sauna once every week or so. When Im rebounding I notice that I get a pain in my left collar bone. I always massage the area before and after. I thought after rebounding for this long the pain might go away. Its not so painful but its uncomfortable and im wondering if this is anything to be concerned about? My partner recently tried rebounding and he said he felt pain also. We've done a bunch of detoxes, CBO, mold etc, both walk alot and exercise and generally pretty healthy.                                   Bryan: Hi Dr. C, I was wondering if you had any thoughts or opinions on Kratom. I've heard you discuss nicotine, cannabis and various other psychedelics on your podcast and their "potential" medicinal benefits but never heard you mention Kratom. Do you have any opinions on this plant? More harm than good? Just curious to hear your thoughts. Thanks,                                                                               Anthony: Hi Doctor Cabral, THANK YOU for all you do. Our 12 year old son seems to have red bags under his eyes more often than we think he should. He also has a small patch of warts on his upper forehead, a slightly bigger wart on the top of his foot and a small patch of bumps on his upper forearm hear his elbow. We had his blood work done taken and it came back with no issues. We also had a food sensitivity test done = IgE Allergy High is cashew, flax seed, green pea, lima bean, navy bean, and his IgG Sensitivity highs being turkey, with many moderate foods on both the allergy and sensitivity sides. Just wondering what your input would be. Thank you Anthony                                                                  Anonymous: Hi Dr. Cabral, I truly resonate with your philosophy of addressing the root cause rather than masking symptoms. I've listened to all your podcasts and read your book, and I really appreciate your holistic approach. I'm also an IHP2. My question is about blood sugar imbalances. Most natural health books I've read on this topic tend to focus on symptom management through low-carb diets. Do you have a book you'd recommend that explores how to restore cell membrane function and rebalance this dynamic at the deepest level? Thank you for your time and for all the work you do.                          Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/3592 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Send us a textMost wellness advice tries to stamp out oxidative stress. We make a different case: the right dose of stress is the signal that builds resilience. From the first snowfall chat to a deep dive on electrons, mitochondria, and energy flow, we walk through how redox balance—reduction and oxidation—is the unseen driver of better fitness, metabolism, and healthy aging. Rather than drowning your cells in pharmacologic antioxidant doses, we show why whole foods, intelligent training, and hormetic practices switch on the body's superior, built-in defenses.We break down how reactive oxygen species act as messengers that activate NRF2 and tune NF kappa B, leading to stronger antioxidant enzymes like superoxide dismutase, catalase, and glutathione. You'll hear why studies on high-dose vitamin A, E, and isolated polyphenols have disappointed or even backfired, and how funding bias confuses the supplement hype cycles. We connect these insights to practical levers: balancing training intensity to avoid chronic overreach, using time-restricted eating to spur ketone-driven repair, and introducing sauna, cold exposure, and real daylight to enhance mitochondrial function and recovery.Food-first takes center stage. We discuss the risks of seed oils and excessive polyunsaturated fats on membrane stability and oxidative load, plus simple swaps toward olive oil, avocado, and nutrient-dense whole foods. Micronutrients like selenium, zinc, and sulfur amino acids matter because they power your endogenous antioxidant systems. The goal isn't to smother the flame; it's to keep a steady candle that signals adaptation without tipping into a wildfire. We close with a n=1 approach—listen to energy, sleep, and training feedback—and small experiments that reveal your best balance.If this resonated, follow the show, share it with a friend who loves the science of training and longevity, and leave a quick review so more listeners can find us.For video, open access reference papers and PP slide deck go to: www.thehealthedgepodcast.com

Hydrogen tablets will revolutionise medicine within five years: mark my words. We're talking about delivering medications, mitigating concussive injuries, repairing the endothelium, enhancing GLP-1 secretion, and restoring true redox homeostasis through your body's own NRF2 pathway. What would healthcare look like if we prioritised cellular homeostasis over symptom suppression? CLICK HERE TO BECOME GARYS VIP!: https://bit.ly/4ai0Xwg Thank you to our partners H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp WHOOP: JOIN AND GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij CARAWAY: “ULTIMATE” FOR 10% OFF: https://bit.ly/3Q1VmkC HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: https://bit.ly/44fFza0 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9 Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 Intro of Show 02:06 Hydrogen Gas Definition 04:30 What is Redox Homeostasis? 05:09 The Power of Hydrogen Gas 07:17 Oxidative Balance is the Goal The Ultimate Human with Gary Brecka Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The Content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Learn more about your ad choices. Visit megaphone.fm/adchoices

What if the reason you're tired isn't motivation…or age…or willpower……but your cells trying to protect you?In this episode, we go deeper into the inner world of your mitochondria — the tiny “suns” inside your cells that produce nearly all your energy. And more importantly, we explore the four antioxidant repair systems that determine how well you recover from stress, aging, illness, exercise, concussion, perimenopause, and everyday life:✨ SOD2 (superoxide dismutase) – your spark catcher✨ Catalase – your cellular smoke-ventilation system✨ Glutathione – your master repair crew✨ NRF2 – your genetic “repair code” activatorYou'll learn how these systems work, why they matter for energy and metabolism, and how your genes influence their efficiency. And you'll learn the surprisingly simple daily nutrients, foods, and habits that can radically strengthen this entire antioxidant canopy.BIG NEWSFor the first time all year, two of the DNA companies I partner with are offering Thanksgiving-week pricing on their nutrigenomics panels. These tests help you understand your antioxidant pathways, methylation, detox, hormones, and metabolism on a deeper level.3x4https://3x4genetics.comNutritionGenomehttps://nutritiongenome.comComing Soon: The Metabolic Restoration ProjectA small-group experience where we combine nutrigenomics, metabolic nutrition, mitochondrial support, and daily lifestyle rhythms to help you rebuild energy, hormone balance, and metabolic flow.If you'd like to be part of this founders group at a deeply discounted price send me a DM @shelleyswapp on instagram or email me at hello@shelleyswapp.com

For this week's episode of the Clinician's Corner, we've gone into the archives to pull out another clinical pearl from one of our favorite episodes - and today we discuss the powerful healing properties of sulforaphane with David Roberts & Dr. John Gildea, from Mara Labs.   This interview first aired in 2023, and the full interview can be viewed here.   Clinical pearls we extracted from the original interview: The story behind BrocElite, a stabilized sulforaphane supplement The motivation behind the research  The scientific background on sulforaphane (e.g., its development and stabilization) How sulforaphane plays a role in cancer and chemotherapy  The Clinician's Corner is brought to you by the Institute of Restorative Health. Follow us: https://www.instagram.com/instituteofrestorativehealth/   Connect with Mara Labs: Website: https://mara-labs.com/ Instagram: https://www.instagram.com/themaralabs/?hl=en Facebook: https://www.facebook.com/themaralabs/    Speaker bios: David Roberts holds a MPH from Johns Hopkins, a Masters in BME from the UVA, and a Bachelors in EE and BME from Duke. David has more than 20 years of public health experience on three continents. In 2014 David cofounded the gut supplement, RESTORE, now called ION.    Dr. John Gildea is Cell Pathophysiologist and Molecular Geneticist with 33 years of scientific research experience at the bench in both industrial and academic labs.  A guiding principle of his work is to establish innovative optimized model systems and assays in order to robustly investigate both normal and pathological states. He has extensive expertise establishing and investigating in-vivo, ex-vivo, primary and immortalized cell culture systems, molecular biology, antibody based and nucleic acid based diagnostic assay development, electron and fluorescence microscopy and flow cytometry. Dr. Gildea has published 63 peer reviewed articles, 3 book chapters, 3 reviews, 3 patents, and has 3173 citations.    Keywords: functional health, sulforaphane, broccoli, breast cancer, oncology, chemosensitizer, glucoraphanin, myrosinase, supplement, restorative health, anti cancer, clinical skills, chronic disease, cancer models, NRF2, antioxidant system, chemotherapy, metastasis, Mara Labs, Baroque Elite, broccoli sprouts, juicing, practitioner training, case studies, gastrointestinal healing, functional medicine, curriculum, certification, clinical mastery, immune system, detoxification Disclaimer: The views expressed in the IRH Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of the Institute of Restorative Health, LLC. The Institute of Restorative Health, LLC does not specifically endorse or approve of any of the information or opinions expressed in the IRH Clinician's Corner series. The information and opinions expressed in the IRH Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. The Institute of Restorative Health, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the IRH Clinician's Corner series. By viewing or listening to this information, you agree to hold the Institute of Restorative Health, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

Episode 4 — Starlight Inside, The Mitochondria EpisodeShow Notes / DescriptionIn today's episode, we zoom inward—into the living universe inside your cells—to explore how your mitochondria (your body's tiny suns) create the energy that fuels everything you do… and what happens when life burns too hot for too long.We talk about the ancient origins of your mitochondria, why their DNA is passed almost entirely through your maternal line, and how your mother's light and your father's genetic architecture work together to shape your vitality, resilience, and metabolism.Then we step into the “forest canopy” around your mitochondria—your antioxidant and repair systems—including superoxide dismutase, catalase, glutathione, and the master regulator NRF2.You'll learn:✨ Why stress, infections, chronic busyness, poor sleep, toxins, and nutritional deficiencies can overwhelm your antioxidant canopy✨ How your body actually protects you by dimming energy (instead of failing)✨ Why some people rebound quickly and others crash harder✨ And how daily nourishment rebuilds your internal ecosystemWe also meet “Anna,” a high-performing woman who didn't realize her exhaustion was a sign of her body protecting her—not betraying her.Her story will help you understand why energy depletion often isn't about willpower, but about biology.Finally, I'll share a deeply personal story from my herbal medicine training—a free clinic, a big pot of kitchari, and the moment I learned how profoundly simple nourishment can shift the nervous system.This episode is for you if:

Have you heard of sulforaphane? Want to know how to harness the benefits of this powerful compound? Tune in to learn all about sulforaphane—a powerhouse phytonutrient that activates detox and antioxidant pathways to protect your cells.  In this episode, we will unpack how this potent compound supports the body's natural defense systems, working through the NRF2 pathway to reduce oxidative stress, enhance cellular detoxification, and promote resilience against modern day toxin exposure. We also discuss how food preparation impacts sulforaphane yield, why gut health matters for its conversion, and how to maximize levels through broccoli sprouts, seed extracts, and targeted supplementation.  We also unveil the exciting reformulation of Cellular Antiox, featuring clinically validated broccoli seed extract for enhanced cellular protection alongside glutathione support! Also in this episode:  Shop NEW Cellular Antiox with code CELLULAR15 Naturally Nourished Academy - Now Enrolling with Early Bird Pricing!  What is sulforaphane? Who can benefit from sulforaphane? Sulforaphane in the research Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer - PubMed Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China - PMC Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects - PubMed Effects of broccoli sprout supplements enriched in glucoraphanin on liver functions in healthy middle-aged adults with high-normal serum hepatic biomarkers: A randomized controlled trial Long-lasting beneficial effects of maternal intake of sulforaphane glucosinolate on gut microbiota in adult offspring - ScienceDirect Broccoli or Sulforaphane: Is It the Source or Dose That Matters? - PMC Sulforaphane treatment of autism spectrum disorder (ASD) | PNAS Prep and cooking to maximize sulforaphane Why the gut microbiome matters Probiotic Challenge Protocol How to get sulforaphane in the diet Considerations for BroccoDetox New Cellular Antiox Formulation Setria® Glutathione (250 mg): Clinically studied, reduced form, ready to use N-Acetylcysteine (1,000 mg): A powerful precursor, provides cysteine to fuel internal glutathione production Broccoli Seed Extract 40mg (2mg glucoraphanin): Activates Nrf2 pathway, upregulates endogenous antioxidant production, including glutathione Vitamin B6 (5 mg): Essential cofactor for amino acid metabolism and methylation, supports efficient detox and glutathione recycling New bovine gelatin capsule with silica as an added feature!   Sponsors for this episode:  This episode is sponsored by FOND Bone Broth, your sous chef in a jar. FOND's bone broths and tallows are produced in small batches with premium ingredients from verified regenerative ranches. Their ingredients are synergistically paired for maximum absorption, nutritional benefit, and flavor. Use code NATURALLY to save at fondbonebroth.com 

Episode DescriptionWhat if detox wasn't about deprivation, but about bringing your body back into flow?In this episode, Shelley Swapp blends Traditional Chinese Medicine philosophy with cutting-edge nutrigenomics to reveal how your body's natural detox pathways influence hormones, metabolism, and energy. You'll learn why restoring gentle flow—rather than forcing a cleanse—is the key to long-term balance.Shelley explains how genes like NRF2, GSTM1, GSTT1, GCLM, and COMT shape your ability to clear hormones and toxins, and how everyday foods, herbs, and joyful practices can switch those genes on again. From the “savings-account” power of glutathione to the hormone-balancing effects of sulforaphane from broccoli sprouts, this episode turns complex biochemistry into everyday wisdom.“Your genes may show where the river narrows, but your lifestyle is the water itself—bringing life back into those channels, one small, consistent ripple at a time.”

Most people try to “heal” their brain with supplements, mindset, or meditation—but this episode reveals the deeper protocol to actually grow a new brain, reverse stress damage, activate 1,100 healing genes, and unlock higher human performance at any age. You'll learn how neuroplasticity, mitochondria repair, plant-based NRF2 activators, and energetic practices work together to rebuild the brain and extend longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Alberto Villoldo, Ph.D.—medical anthropologist, neuroscientist, energy medicine pioneer, and founder of The Four Winds Society, the gold-standard school for modern shamans. He has spent 25+ years studying Amazonian and Andean healing traditions, led the Biological Self-Regulation Lab at San Francisco State University to explore psychosomatic medicine, and authored more than 25 bestselling books on neuroscience, functional medicine, and energy healing. Few people on earth bridge ancient biohacking and modern brain science at this level. He also reveals the forms of nicotine that are safest (spoiler: it's not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown. You'll learn: • How to grow a new brain every 22 days using neuroplasticity and mitochondria support • Why plant medicines and NRF2 activators can turn on 1,100 healing genes in 24 hours • The surprising link between nootropics, psychedelics, serotonin, and endogenous DMT • How mindset, belief systems, and placebo/nocebo shape immune function and metabolism • Why RFK's chronic disease warning connects to viral evolution and immune collapse • The real reason carnivore diets work—and when they fail without gut repair • Peptides, GLP-1 agonists, and the future of functional medicine hacking • Why most people sabotage themselves and how to stop fighting your own biology This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: NRF2 activation, Neurogenesis and hippocampus repair, Plant-based epigenetic triggers, Psychosomatic health, Serotonin to DMT conversion, Pineal gland methylation, Parasites and brain inflammation, Viral-driven evolution, GLP-1 agonists and longevity, Psilocybin lifespan extension, Autophagy and brain cleanup, Energetic medicine training, Functional peptides, BPC-157, Breathwork and CO2 tolerance, mTOR cycling, Cold exposure and dopamine, Mindset-driven immune function Thank you to our sponsors! • EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. • Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. • Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. • fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Learn more from Alberto at: www.thefourwinds.com and www.albertovilloldo.net • Buy the book ‘Grow A New Brain': https://a.co/d/5lVhrVy • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction & Ayahuasca Story 3:15 — Shamanism Beyond Plant Medicine 6:53 — Losing Your Mind to Evolve 10:45 — The 22-Day New Brain Cycle 12:53 — Plant Communication & Direct Knowing 15:35 — Parasites, Liver Failure & Brain Damage 20:25 — Remote Healing & CIA Research 22:40 — Tryptophan, Turkey Farmers & Brain Chemistry 25:19 — Viruses as Evolutionary Drivers 30:30 — Psilocybin & Life Extension 35:25 — Healing with Mindset + Biology 38:52 — Spirit, Purpose & Growing Gods 43:49 — Plants, Protein & mTOR 49:07 — Training the Four Brains 51:16 — Cold Exposure: Pain vs Suffering 54:40 — Who Am I? Living the Question 55:25 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if having the same gene as your sister doesn't mean you'll have the same outcome? What if trauma and nervous system dysregulation could be the difference between expressing a genetic disease—or not? In this mini episode, Dr. Aimie Apigian answers a question from Rachel in Texas, who discovered she carries the BRCA gene mutation. Despite making the same lifestyle changes as her sister—who also has the mutation—Rachel developed breast cancer while her sister remained healthy. Why? Dr. Aimie reveals the biological mechanism that connects nervous system dysregulation to genetic expression: oxidative stress. This episode offers a scientifically grounded yet hopeful perspective on why two people with identical genetics can have vastly different health outcomes—and what you can do about it. In this episode you'll hear more about: Why BRCA mutation carriers have a 45-72% lifetime breast cancer risk (versus 12-13% in the general population)—but not everyone with the gene develops cancer The biological link between nervous system dysregulation and oxidative damage to DNA How BRCA genes interact with NRF2 antioxidant pathways, creating increased vulnerability to oxidative stress Why both sympathetic activation (stress/anxiety) and dorsal vagal shutdown (depression/numbness) decrease your body's ability to clear oxidative stress The "calm alive" state: when your body naturally engages its healing and antioxidant repair mechanisms Dana's story from The Biology of Trauma—a physician with childhood trauma who found a breast lump and learned to repair nervous system dysregulation Practical tools: why vitamin C and antioxidant-rich foods (broccoli, blueberries) matter for genetic conditions How somatic self-practices can quickly shift your nervous system state and support cellular repair Why having a genetic condition doesn't mean you're powerless—epigenetics shows us DNA expression can change Genetics load the gun, but environment and nervous system state pull the trigger. This episode is a powerful reminder that even when you carry genetic risk, your nervous system regulation, oxidative stress levels, and daily practices can dramatically influence whether those genes are expressed. Your biology is not a life sentence.

Is aging a disease… or just part of being human?In this episode, David Roberts and Dr. John Gildea dig into that big question. They talk about how our modern habits may be speeding up aging, why inflammation sits at the center of so many health problems, and what science is uncovering about slowing things down.From stem cells and cellular therapies to diet, supplements, and the power of sulforaphane, you'll hear how everyday choices and cutting-edge research are coming together to help us live longer, healthier lives.

Ataxia is a neurologic symptom that refers to incoordination of voluntary movement, typically causing gait dysfunction and imbalance. Genetic testing and counseling can be used to identify the type of ataxia and to assess the risk for unaffected family members. In this episode, Katie Grouse, MD, FAAN, speaks with Theresa A. Zesiewicz, MD, FAAN, author of the article “Ataxia” in the Continuum® August 2025 Movement Disorders issue. Dr. Grouse is a Continuum® Audio interviewer and a clinical assistant professor at the University of California San Francisco in San Francisco, California. Dr. Zesiewicz is a professor of neurology and director at the University of South Florida Ataxia Research Center, and the medical director at the University of South Florida Movement Disorders Neuromodulation Center at the University of South Florida and at the James A. Haley Veteran's Hospital in Tampa, Florida. Additional Resources Read the article: Ataxia Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Grouse: This is Dr Katie Grouse. Today I'm interviewing Dr Theresa Zesiewicz about her article on ataxia, which appears in the August 2025 Continuum issue on movement disorders. Welcome to the podcast, and please introduce yourself to our audience.  Dr Zesiewicz: Well, thank you, Dr Grouse. I'm Dr Theresa Zesiewicz, otherwise known as Dr Z, and I'm happy to be here. Dr Grouse: I have to say, I really enjoyed reading your article. It was a really great refresher for myself as a general neurologist on the topic of ataxia and a really great reminder on a great framework to approach diagnosis and management. But I wanted to start off by asking what you feel is the key message that you hope our listeners will take away from reading your article. Dr Zesiewicz: Yes, so, thanks. I think one of the key messages is that there has been an explosion and renaissance of genetic testing in the past 10 years that has really revolutionized the field of ataxia and has made diagnosis easier for us, more manageable, and hopefully will lead to treatments in the future. So, I think that's a major step forward for our field in terms of genetic techniques over the last 10 years, and even over the last 30 years. There's just been so many diseases that have been identified genetically. So, I think that's a really important take-home message. The other take-home message is that the first drug to treat Friedreich's ataxia, called omaveloxolone, came about about two years ago. This was also a really landmark discovery. As you know, a lot of these ataxias are very difficult to treat. Dr Grouse: Now pivoting back to thinking about the approach to diagnosis of ataxia, how does the timeline of the onset of ataxia symptoms inform your approach? Dr Zesiewicz: The timeline is important because ataxia can be acute, subacute or chronic in nature. And the timeline is important because, if it's acute, it may mean that the ataxia took place over seconds to hours. This may mean a toxic problem or a hypoxic problem. Whereas a chronic ataxia can occur over many years, and that can inform more of a neurodegenerative or more of a genetic etiology. So, taking a very detailed history on the patient is very important. Sometimes I ask them, what is the last time you remember that you walked normal? And that can be a wedding, that can be a graduation. Just some timeline, some point, that the patient actually walked correctly before they remember having to hold onto a railing or taking extra steps to make sure that they didn't fall down, that they didn't have imbalance. That sometimes that's a good way to ask the patient when is the last time they had a problem. And they can help you to try to figure out how long these symptoms have been going on. Dr Grouse: I really appreciate that advice. I will say that I agree, it can sometimes be really hard to get patients to really think back to when they really started to notice something was different. So, I like the idea of referencing back to a big event that may be more memorable to them. Now, given that framework of, you know, thinking through the timeline, could you walk us through your approach to the evaluation of a patient who presents to your clinic with that balance difficulties once you've established that? Dr Zesiewicz: Sure. So, the first thing is to determine whether the patient truly has ataxia. So, do they have imbalance? Do they have a wide base gait? That's very important because patients come in frequently to your clinic and they'll have balance problems, but they can have knee issues or hip issues, neuropathy, something like that. And sometimes what we say to the residents and the students is, usually ataxia or cerebellar symptoms go together with other problems, like ocular problems are really common in cerebellar syndromes. Or dysmetria, pass pointing, speech disorder like dysarthria. So, not only do you need to look at the gait, but you should look at the other symptoms surrounding the gait to see if you think that the patient actually has a cerebellar syndrome. Or do they have something like a vestibular ataxia which would have more vertigo? Or do they have a sensory ataxia, which would occur if a person closes his eyes or has more ataxia when he or she is in the dark? So, you have to think about what you're looking at is the cerebellar syndrome. And then once we look to see if the patient truly has a cerebellar syndrome, then we look at the age, we look at---as you said before, the timeline. Is this acute, subacute, or chronic? And usually I think of ataxia as falling into three categories. It's either acquired, it's either hereditary, or it's neurodegenerative. It can be hereditary. And if it's not hereditary, is it acquired, or is it something like a multiple system atrophy or a parkinsonism or something like that? So, we try to put that together and start to narrow down on the diagnosis, thinking about those parameters. Dr Grouse: That's really a helpful way to think through it. And it is true, it can get very complex when patients come in with balance difficulties. There's so many things you need to think about, but that is a great way to think about it. Of course, we know that most people who come in to the Movements Disorders clinic are getting MRI scans of their brains. But I'm curious, in which cases of patients with cerebellar ataxia do you find the MRI to be particularly helpful in the diagnosis? Dr Zesiewicz: So, an MRI can be very important. Not always, but- so, something like multiple system atrophy type C where you may see a hot cross bun sign or a pontine hyperintensity on the T2-weighted image, that would be helpful. But of course, that doesn't make the diagnosis. It's something that may help you with the diagnosis. In FXTAS, which is fragile X tremor/ataxia syndrome, the patient may have the middle cerebellar peduncle sign or the symmetric hyperintensity in the middle cerebellar peduncles, which is often visible but not always. Something like Wernicke's, where you see an abnormality of the mammillary bodies. Wilson's disease, which is quite rare, T2-weighted image may show hyperintensities in the putamen in something like Wilson's disease. Those are the main MRI abnormalities, I think, with ataxia. And then we look at the cerebellum itself. I mean, that seems self-evident, but if you look at a sagittal section of the MRI and you see just a really significant atrophy of the cerebellum, that's going to help you determine whether you really have a cerebellar syndrome. Dr Grouse: That's really encouraging to hear a good message for all of us who sometimes feel like maybe we're missing something. It's good to know that information can always come up down the line to make things more clear. Your article does a great review of spinal cerebellar ataxia, but I found it interesting learning about the more recently described syndrome of SCA 27B. Would you mind telling us more about that and other really common forms of SCA that's good to keep in mind? Dr Zesiewicz: Sure. So, there are now 49 types of spinal cerebellar ataxia that have been identified. The most common are the polyglutamine repeat diseases: so, spinocerebellar ataxia type 3 or type 2, type 6, are probably the most common. One of the most recent spinocerebellar ataxias to be genetically identified and clinically identified is spinocerebellar ataxia 27B. This is caused by a GAA expansion repeat in the first intron of the fibroblast growth factor on chromosome 13. And the symptoms do include ataxia, eye problems, downbeat nystagmus, other nystagmus, vertical, and diplopia. It appears to be a more common form of adult-onset ataxia, and probably more common than was originally thought. It may account for a substantial number of ataxias, like, a substantial percentage of ataxias that we didn't know about. So, this was really a amazing discovery on SCA 27B. Dr Grouse: Now a lot of us I think feel a little anxious when we think about genetic testing for ataxia simply because there's so many forms, things are changing quickly. Do you have a rule of thumb or a kind of a framework that we can think of as we approach how we should be thinking about getting genetic testing for the subset of patients? Dr Zesiewicz: Sure. And I think that this is where age comes into play a lot. So, if you have a child who's 10, 11, or 12 who's having balance problems in the schoolyard, does not have a history of ataxia in the family, the teachers are telling you that the child is not running correctly, they're having problems with physical education, that is someone who you would think about testing for Friedreich's ataxia. A preteen or a child, that would be one thing that would be important to test. When you talk to your patient, it's important to really take a detailed family history. Not just mom or dad, but ethnicity, grandparents, etc. And sometimes, once in a while, you come up with a known spinal cerebellar ataxia. Then you can just test for that. So, if a person is from Portugal or has Portugal background and they have ataxia and the parents had ataxia, you would think of spinal cerebellar ataxia type 3. Or if they're Brazilian, or if the person is from a certain area of Cuba and mom and dad had ataxia and that person has ataxia, you would think of spinal cerebellar ataxia type 2. Or if a person has ataxia and their parent had blindness or visual problems, you may be more likely to think of spinal cerebellar ataxia type 7, for example. If they have that---either they have a known genetic cause in in the family, first degree family, or they come from an area of the world in which we can pinpoint what type we think it is---you can go ahead and get those tests. If not, you can take an ataxia comprehensive panel. Many times now, if you take the panel and the panel is negative, it will reflex to the whole exome gene sequencing, where we're finding really unusual and more rare types of ataxia, which are very interesting. Spinal cerebellar ataxia type 32, spinal cerebellar ataxia type 36, I had a spinal cerebellar ataxia type 15. So, I think you should start with the age, then the family history, then where the person is from. And then, if none of those work out, you can get a comprehensive panel, and then go on to whole exome gene sequencing. Dr Grouse: That's really, really useful. Thank you so much for breaking that down in a really simple way that a lot of us can take with us. Pivoting a little bit now back towards different types of acquired ataxias, what are some typical lab tests that you recommend for that type of workup? Dr Zesiewicz: Again, if there's no genetic history and the person does not appear to have a neurodegenerative disease, we do test for acquired ataxias. Acquired ataxias can be complex. Many times, they are in the autoimmune family. So, what we start with are just basic labs like a CBC or a CMP, but then we tried to look at some of the other abnormalities that could cause ataxia. So, celiac disease, stiff person syndrome. So, you would look at anti-glutamic acid decarboxylase antibodies, Hashimoto's---so, antithyroglobulin antibodies or antithyroperoxidase antibodies would be helpful. You know, in a case of where the patients may have an underlying neoplasm, maybe even a paraneoplastic workup, such as an anti-Hu, anti-Yo, anti-Ri. A person has breast cancer, for example, you may want to take a paraneoplastic panel. I've been getting more of the anti-autoimmune encephalitis panels in some cases, that were- that are very interesting. And then, you know, things that sometimes we forget now like the syphilis test, thyroid-stimulating test, take a B12 and folate, for example. That would be important. Those are some of the labs. We just have on our electronic chart a group of acquired labs for ataxia. If we can't find any other reason, we just go ahead and try to get those. Dr Grouse: Now, I'm curious what you think is the most challenging aspect of diagnosing a patient with cerebellar ataxia? Dr Zesiewicz: So, for those of us who see many of these patients a day, some of the hardest patients are the ones that---regardless of the workup that we do, we've narrowed it down, it's not hereditary. You know, they've been through the whole exome gene sequencing and we've done the acquired ataxia workup. It doesn't appear to be that. And then we've looked for parkinsonism and neurodegenerative diseases, and it doesn't appear to be that either; like, the alpha-synuclein will be negative. Those are the toughest patients, where we think we've done everything and we still don't have the answer. So, I've had patients in whom I've taken care of family members years and years ago, they had a presumed diagnosis, and later on I've seen their children or other family members. And with the advent of the genetic tests that we have, like whole exome gene sequencing, we have now been able to give the patient and the family a definitive diagnosis that they didn't have 25 years ago. So, I would say don't give up hope. Retesting is important, and as science continues and we get more information and we make more landmark discoveries in genetics, you may be better able to diagnose the patient. Dr Grouse: I was wondering if you had any recommendations regarding either some tips and tricks, some pearls of wisdom you can impart to us regarding the work of ataxia, or conversely, any big pitfalls that you can help us avoid? I would love to hear about it. Dr Zesiewicz: Yeah, there's no easy way to treat or diagnose ataxia patients. I've always felt that the more patients you see- and sounds easy, but the more patients you see, the better you're going to become at it, and eventually things are going to fall into place. You'll begin to see similarities in patients, etc. I think it's important not only to make sure that a person has ataxia, but again, look at the other signs and symptoms that may point to ataxia that you'll see in a cerebellar syndrome. I think it's important to do a full neuroexam. If a person has spasticity, that may point you more towards a certain type of ataxia than if a person has no reflexes, for example, that we see in Friedreich's ataxia. Some of the ocular findings are very interesting as well. It's important to know if a person has a tremor. I've seen several Wilson's disease cases in my life with ataxia. They're very important. I think a full neuroexam and also a very detailed history would be very helpful. Dr Grouse: Tell us about some promising developments in the diagnosis and management of ataxia that we should be on the lookout for. Dr Zesiewicz: The first drug for Friedreich's ataxia was FDA-approved two years ago, which was an NRF2 activator, which was extremely exciting and promising. There are also several medications that are now in front of the FDA that may also be very promising and have gone through long clinical trials. There's a medication that's related to riluzole, which is a medication used for amyotrophic lateral sclerosis, that has been through about seven years of testing. That is before the FDA as well for spinal cerebellar ataxia. Friedreich's ataxia has now completed the first cardiac gene therapy program with AAV vectors, which- we're waiting for full results, but that's a cardiac test. But I would assume that in the future, neurological gene therapy is not far behind if we've already done cardiac gene therapy and Friedreich's ataxia. So, you know, some of these AAV vector-based genetic therapies may be very helpful, as well as ASO, antisense oligonucleotides, for example. And I think in the future, other things to think about are the CRISPR/Cas9 technology for potential treatment of ataxia. It is a very exciting time, and some major promising therapies have been realized in the past 2 to 3 years. Dr Grouse: Well, that's really exciting, and we'll all look forward to seeing these becoming more clinically applicable in the future. So, thank you so much for coming to talk with us today. Dr Zesiewicz: Thank you. Dr Grouse: Again, today I've been interviewing Dr Theresa Zesiewicz about her article on ataxia, which appears in the August 2025 Continuum issue on movement disorders. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Most people think broccoli is a superfood, but the reality is more nuanced. In this episode of The Human Upgrade, Host Dave Asprey explores the good and bad of broccoli—why adult broccoli can block thyroid function and cause gut issues, while broccoli seeds deliver sulforaphane, the powerful compound that activates all three of your body's detox pathways. You'll learn how sulforaphane protects against glyphosate, repairs leaky gut, and upgrades mitochondria, metabolism, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dave is joined by two Johns Hopkins–trained researchers whose expertise in biohacking, biochemistry, and functional medicine makes them trusted leaders in the field. Together they reveal how sulforaphane, berberine, curcumin, and alpha-lipoic acid outperform bulk vegetables and even rival GLP-1 weight loss drugs—delivering natural ways to improve metabolism, regulate dopamine, and protect the brain. Their research shows how targeted supplements can boost neuroplasticity, brain optimization, and human performance without the side effects of pharmaceuticals. Dave and his guests break down why bulk vegetables don't deliver enough beneficial compounds, how to hack plant toxins for maximum benefit, and why supplement stacks often outperform carnivore, vegan, or high-vegetable diets for long-term health. You'll discover how biohacking tools like fasting, ketosis, nootropics, cold therapy, and sleep optimization amplify these compounds for smarter not harder living. You'll Learn: • Why adult broccoli can disrupt thyroid function while broccoli seeds fuel detox and longevity • How sulforaphane, berberine, curcumin, and alpha-lipoic acid support metabolism and mitochondria • Why natural compounds can rival GLP-1 drugs for weight loss and energy regulation • The connection between glyphosate, leaky gut, inflammation, and brain fog • How to stack supplements with fasting, ketosis, and cold therapy for brain optimization • Why functional medicine and biohacking provide better long-term solutions than fad diets • The smarter not harder way to extract benefits from plants without the toxic load This episode is essential for anyone serious about biohacking, upgrading metabolism, extending longevity, and achieving high performance with resilience and clarity. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: sulforaphane supplements, broccoli seed extract, detox pathways phase 1 2 3, NRF2 activation, glyphosate gut health, leaky gut repair biohacking, thyroid blockers broccoli, DIM I3C compounds, functional medicine detox, Johns Hopkins biohacking research, berberine metabolism, alpha lipoic acid mitochondria, curcumin weight loss, GLP-1 natural alternatives, dopamine metabolism regulation, neuroplasticity supplements, fasting and sulforaphane, ketosis and detox synergy, smarter not harder supplements, Dave Asprey broccoli Mara Labs Website: https://mara-labs.com/Dave for 28% off!Resources: -Mara Labs Website: https://mara-labs.com/Davefor 28% off!-BrocElite link: https://partnerships.mara-labs.com/4H6KD28/TZW7X/?&sub4=biohack&uid=123-GLPerfect link: https://partnerships.mara-labs.com/4H6KD28/TZW7X/?&sub4=biohack&uid=123Thank you to our sponsors! EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Mara Labs Website: NEED TO INSERT CODE • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 — Trailer 01:10 — Introduction 01:49 — Broccoli Benefits & Risks 09:24 — Plant Toxins & Modern Diet 12:56 — Mold Detox Experiences 18:30 — Mycotoxins, Glyphosate & Gut Health 26:20 — Metabolic Syndrome & Endotoxins 35:44 — Timing Sulforaphane for Glyphosate Protection 39:35 — Weight Loss & GL Perfect 49:19 — Personalization & Supplement Stacking 55:10 — Sleep, Ketosis & Berberine 58:30 — Alpha Lipoic Acid + Berberine Synergy 1:01:00 — Natural Alternatives to GLP-1 Drugs See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of The Lindsay Elmore Show, Lindsay sits down with David Roberts, co-founder of Mara Labs and a pioneer in sulforaphane supplementation.Sulforaphane, derived from broccoli sprouts, has been called the "master molecule for health" thanks to its ability to support detoxification, reduce inflammation, enhance brain health, and improve metabolic function. David shares the science behind stabilizing sulforaphane, explains why most supplements fall short, and discusses its synergistic effects with molecules like curcumin. From detoxing microplastics to balancing hormones and boosting mitochondrial energy, sulforaphane has far-reaching benefits for overall resilience.Key TakeawaysSulforaphane Basics: A compound found in broccoli sprouts with over 37 documented pro-health mechanisms.Brain Health: Increases BDNF, supporting neuroprotection, neurogenesis, and even enhanced dreaming.Detoxification: Activates NRF2 pathways, turning on over 200 antioxidant and detox genes for up to 72 hours.Inflammation: Synergizes with curcumin to reduce NF-kB and IL-6, two key pro-inflammatory markers.Practical Use: Each capsule of Mara Labs' stabilized sulforaphane equals the benefit of 2.5 pounds of broccoli.Metabolic Impact: Helps balance estrogen, supports mitochondrial energy, and assists in reducing belly fat and insulin resistance.Environmental Defense: Aids the body in processing toxins like glyphosate and mobilizing microplastics.Chapter Timestamps01:00 – What is sulforaphane and why it's the “master molecule”03:00 – How sulforaphane supports brain health through BDNF05:00 – Stabilizing sulforaphane and the challenges of supplementation06:45 – David's personal story: breast cancer diagnosis and discovery of sulforaphane08:00 – How sulforaphane is delivered and stabilized in capsules10:00 – The NRF2 pathway and turning on antioxidant defense13:00 – Detox done right: why many “detox programs” fail15:00 – Curcumin and sulforaphane synergy for inflammation reduction18:00 – Internal studies on inflammation markers (IL-6, NF-kB)20:00 – The real role of detoxification vs. buzzwords24:00 – Toxins in modern life: microplastics, glyphosate, and more28:00 – Genetic modification, glyphosate, and long-term toxicity29:30 – Sulforaphane for metabolism, mitochondrial energy, and belly fat32:00 – Additional Mara Labs products supporting metabolism (GLP-1 alternatives)33:00 – How to learn more: Mara Labs discount link

About the Guest(s): Dr. Kristin Hieshetter is a passionate host of the Functional Health Radio and a health expert focusing on functional and neurological health. With ongoing education through the Carrick Institute of Neurology, Dr. Kristin is onboard to become a board-certified neurologist. She is committed to exploring scientific literature and practical health strategies to promote longevity and improve quality of life across various contexts. Dr. Kristin's passion for brain health and energy, structured restoration for youngsters, and continuous learning positions her as an engaging and knowledgeable voice in functional health. Episode Summary: In this intriguing episode of Functional Health Radio, host Dr. Kristin Hieshetter takes listeners on a deep dive into the NRF2 pathway and its remarkable role within the human body. With her characteristic blend of scientific rigor and practicality, Dr. Kristin dissects the complex function of NRF2—nuclear factor erythroid 2-related factor 2—as a cornerstone in antioxidant defense and inflammation control. She explains how NRF2 signaling might revolutionize treatments for inflammatory and neurodegenerative diseases, making this episode a must-listen for health enthusiasts seeking insights into cutting-edge health science. Dr. Kristin's exploration covers NRF2's involvement in cellular protection, detoxification, and its response to environmental and metabolic stressors. With citation to pivotal studies in molecular science, she illuminates NRF2's potential impact on disease processes such as Alzheimer's, cancer, and autoimmune conditions. Her passion for brain health is evident as she links NRF2 activation to improved mitochondrial function and autophagy, underlying its significance in maintaining cognitive function. Through detailed exploration, she emphasizes how compounds like curcumin enhance NRF2 activity, heralding a new frontier in functional health strategies. Key Takeaways: NRF2 Pathway Significance: NRF2 is crucial in regulating the body's response to oxidative stress and inflammation, with promising applications in cancer, neurodegenerative disorders, and metabolic health. Inflammation and Immunity: Inflammation is a key player in various diseases; NRF2 can moderate inflammatory responses by influencing and downregulating harmful gene expressions. Neuroprotective Functions: NRF2 supports brain health by promoting DNA repair, mitochondrial health, and autophagy, suggesting substantial benefits for conditions like Alzheimer's and Parkinson's. Curcumin as NRF2 Activator: The compound curcumin, found in turmeric, activates NRF2 signaling, providing a naturally derived method to enhance cellular defense systems. Lifestyle Recommendations: Strategies such as intermittent fasting and targeted supplementation can support NRF2 activity, promoting better health outcomes and longevity. Notable Quotes: "NRF2 can flip your genes on and off to help you deal with inflammation. Amazing, right?" "This NRF2 can flip itself on or off when you need it. That is incredible." "Autophagy protects you from free radical damage; it helps cells repair themselves." "Learning and memory are enhanced when you are undergoing autophagy." "The NRF2 pathway—inflammation moderation, mitochondrial protection, DNA repair—could become the next therapeutic target in all neurodegenerative diseases." Resources: Molecules Journal: November 2020 publication on the "Overview of NRF2 Signaling Pathway and its Role in Inflammation." International Journal of Molecular Science: September 4, 2021, article by Grzynska et al. on NRF2's role in neurodegenerative diseases. Curcumin Studies: Information on the activation of NRF2 through curcumin, as studied in prostate cancer research. Further Information and Updates: Dr. Kristin's Health Podcast Series (Link to be searched/added separately). Tune in to this enlightening episode today to further your understanding of NRF2's transformative potential in health science. Stay connected with Functional Health Radio for more groundbreaking insights into functional health and wellbeing.

Rhonda Patrick, Ph.D. (@foundmyfitness) is a biomedical scientist and the founder of FoundMyFitness, a platform dedicated to delivering rigorous, evidence-based insights on improving healthspan and mitigating age-related diseases.Sponsors:Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine and other supplements: https://livemomentous.com/tim (code TIM for up to 35% off)David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim (Buy 4 cartons, get the 5th free.)Monarch Money track, budget, plan, and do more with your money: MonarchMoney.com/Tim (50% off your first year at monarchmoney.com with code TIM)Timestamps:[00:00:00] Start.[00:04:54] Dealing with aging parents and other topics on the table.[00:10:43] How a common multivitamin helps reverse cognitive and memory aging.[00:12:04] The importance of supplementation — especially as we age.[00:13:10] Effectively supplementing with omega-3 fish oil to counter APOE4 and Alzheimer's risks.[00:16:50] The CoQ10 and omega-3 protocol that has helped Rhonda's father manage Parkinson's symptoms for nearly a decade.[00:19:28] Sulforaphane: a potent NRF2 activator with an unexpected benefit for Rhonda's mother's tremors.[00:25:34] How Rhonda convinced her mom to start CrossFit and the power of community-based, senior-focused fitness.[00:26:52] The earlier the intervention, the better the outcomes.[00:32:25] Intermittent fasting vs. extended fasting and my own results.[00:44:31] Does fasting destroy muscle mass? Debunking the catabolism fear and understanding the crucial role of the re-feeding phase.[00:57:24] "Dirty" fasting: what really happens to autophagy and metabolic benefits when you add a splash of cream or MCT oil to your coffee?[01:00:44] VO2 max: the one metric that may predict lifespan more accurately than anything else, and how we work to improve it.[01:12:07] How a two-year exercise program reversed heart aging by 20 years in previously sedentary, middle-aged adults.[01:16:18] Lactate isn't the enemy: how vigorous exercise creates a superfuel that protects and grows the brain.[01:20:30] The optimal sauna protocol (temperature and frequency) for slashing dementia risk by 66%.[01:29:17] If you're human, you'll find a use for curcumin.[01:30:43] Creatine for cognition: moving beyond the gym with a powerful, science-backed tool for focus and combating sleep deprivation.[01:42:41] Still vitamin D deficient despite taking supplements? Here's the critical cofactor you're probably missing.[01:53:52] Shocking sources of microplastics in our daily lives, including chewing gum and teabags.[02:04:10] The uncomfortable truth about "moderate" alcohol consumption, cancer risk, and why the "sick quitter" hypothesis makes most older studies unreliable.[02:17:03] The ups and downs of ketamine and psilocybin on cognition and longevity.[02:24:19] Parting thoughts and where to find more from Rhonda.*Show notes for this episode: https://tim.blog/2025/07/24/dr-rhonda-patrick/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Q&A episode, we strip the science-speak out of longevity and hand you the practical takeaways.  I unpack spermidine, NRF2, sirtuins and NAD—three buzzwords that can actually become game-changing tools when you understand how they work inside a woman's body. I share the vetted products in my personal stack, free lifestyle hacks, and a quick framework to choose what suits your goals and genetics—so biohacking stays simple, empowering, and tailored to your life. WE TALK ABOUT:  01:20 – Today's hot-seat Q&A: Spermidine, NRF2, NAD, sirtuins, and stacking strategy  07:25 – What spermidine actually does: Autophagy without the fast (SpermidineLIFE code: BIOHACKINGBRITTANY) 09:30 – NRF2 pathway 101: Flipping your antioxidant “master switch”  13:10 – Natural NRF2 activators 18:20 – NAD decoded: Why your mitochondria runs on this co-enzyme  20:45 – Best—and worst—ways to raise NAD: NOVOS (code: BIOHACKINGBRITTANY) 23:30 – Sirtuins unlocked: Longevity genes that need NAD to work  25:00 – The synergy play: When stacking three pathways makes sense  27:10 – My personal protocol & dosing tips SPONSORS: Swap restless nights for real recovery with Magnesium Breakthrough by BiOptimizers (code: BIOHACKINGBRITTANY) — the full-spectrum formula I trust for calmer nerves, balanced hormones, and deep, restorative sleep. RESOURCES: Trying to conceive? Join my Baby Steps Course to optimize your fertility with biohacking. Free gift: Download my hormone-balancing, fertility-boosting chocolate recipe. Explore my luxury retreats and wellness events for women. Shop my faves: Check out my Amazon storefront for wellness essentials. The DNA Blueprint episode with Kashif Khan Kid Gut Resilience: Birth, Stress & Health with Ara Katz of Seed LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

Humans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer's-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly evolved 200,000 years ago, may offer some protection. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40700]

Humans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer's-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly evolved 200,000 years ago, may offer some protection. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40700]

Welcome to "Thriving in Midlife Redefining Aging with Wellness" the podcast where we discuss how to live an extraordinary life in every aspect. I'm your host, Kellie Lupsha, a high-performance health coach, who is delighted to be your guide to vitality.In this episode, I dive deep into one of the most critical yet underappreciated players in health and wellness, NRF2. Often referred to as the "master regulator of gene expression," NRF2 holds the key to unlocking your body's natural ability to fight oxidative stress, reduce inflammation, detoxify, and even slow down aging. Whether you're new to NRF2 or already familiar with its potential, this episode breaks down the science behind why it's a game-changer for achieving total wellness.Key Highlights:Discover what makes NRF2 a cornerstone of cellular health and how it functions as the "thermostat" for your genes.Learn about the oxidative stress theory of aging and how activating NRF2 can help combat the effects of free radicals on your body.Explore how NRF2 plays a role in preventing and managing over 200 diseases.Find out why supporting your body's daily detox pathways is essential—and how NRF2 helps optimize these processes naturally.Uncover how NRF2 reduces chronic inflammation, a root cause of many modern illnesses, by regulating inflammatory pathways.Dive into the connection between NRF2 activation, mitochondrial function, and extending both lifespan and healthspan.Insights on clinically-researched methods to activate NRF2, including lifestyle changes and evidence-based supplements.Key Takeaways"If you want to reduce your risk of disease, and you're already into health and wellness or take supplements, you need to be on an NRF2 activator. Hands down, it is the mothership—you must activate your body with NRF2." —Kellie Lupsha"Our body is so innate and beautiful. It has so much intuition built inside of us, and that pathway turns on and off, on and off. So I love the fact that nothing else has been proven to be more effective than [Protandim NRF2] in raising NRF2 activation in your body compared to any other product out there on the market." —Kellie LupshaFREE GIFT

Story at-a-glance Heavy metals like lead, mercury, and arsenic enter your body through various environmental sources and cause numerous health issues, including gastrointestinal problems and neurological symptoms Heavy metal toxicity is diagnosed through blood tests, urine analysis, and hair/nail samples, though regular testing isn't usually done as most people naturally have trace amounts A comprehensive detox plan includes cleansing the gastrointestinal tract with binders, optimizing glutathione levels, and upregulating Nrf2 to enhance cellular defense against toxins Research shows sweating through exercise and sauna sessions is one of the most effective natural methods for removing heavy metals from the body For optimal detoxification, combine detoxing with high-intensity exercise (limited to 75 minutes weekly) and regular sauna sessions while maintaining proper hydration

Broadcast from KSQD, Santa Cruz on 5-08-2025: Dr. Dawn examines groundbreaking research on rising rates of early-onset colorectal cancer worldwide, explaining how researchers have identified a bacterial toxin called colibactin produced by specific E. coli strains that appears to cause early genetic mutations in cancer-controlling genes, potentially explaining why younger generations face significantly higher cancer risks. She discusses how modern medical practices like antibiotic overuse and cesarean deliveries may disrupt protective gut microbiomes, while diets low in fiber and high in animal fats create conditions where harmful bacteria thrive and damage the protective mucosal barrier, potentially exposing colon cells to cancer-causing mutations. Dr. Dawn explains fascinating research on transgenerational memory in C. elegans worms and mice, where learned aversions to specific odors are genetically passed down to offspring through epigenetic mechanisms involving methylation and RNA pathways, challenging traditional views on inheritance and suggesting implications for human genetics. Responding to an email about posterior tibial tendon disease (PTTD), she offers comprehensive management strategies including cross-massage with ice, proper footwear selection, careful stretching techniques, and anti-inflammatory approaches while cautioning against invasive procedures like steroid injections that might weaken tendons. She discusses promising research on rosemary's potential in Alzheimer's treatment, explaining how carnosic acid activates the NRF2 pathway that controls antioxidant proteins, with researchers developing a more stable chemical analog that reduced inflammation and improved memory in mouse models of Alzheimer's disease. Dr. Dawn provides updates on vaccination recommendations, noting that egg allergy questions are no longer needed before flu vaccines, pneumococcal vaccines are now recommended for all adults over 50, and explaining the small risk of Guillain-Barré syndrome with RSV vaccines compared to the much larger risk of RSV-related deaths. She shares information about a new hypertension risk calculator called PREVENT that reclassifies many patients to lower risk categories, potentially allowing 2.6 million Americans to manage their blood pressure through lifestyle changes rather than medication, particularly benefiting older women who face different risk profiles than men.

Broadcast from KSQD, Santa Cruz on 5-08-2025: Dr. Dawn examines groundbreaking research on rising rates of early-onset colorectal cancer worldwide, explaining how researchers have identified a bacterial toxin called colibactin produced by specific E. coli strains that appears to cause early genetic mutations in cancer-controlling genes, potentially explaining why younger generations face significantly higher cancer risks. She discusses how modern medical practices like antibiotic overuse and cesarean deliveries may disrupt protective gut microbiomes, while diets low in fiber and high in animal fats create conditions where harmful bacteria thrive and damage the protective mucosal barrier, potentially exposing colon cells to cancer-causing mutations. Dr. Dawn explains fascinating research on transgenerational memory in C. elegans worms and mice, where learned aversions to specific odors are genetically passed down to offspring through epigenetic mechanisms involving methylation and RNA pathways, challenging traditional views on inheritance and suggesting implications for human genetics. Responding to an email about posterior tibial tendon disease (PTTD), she offers comprehensive management strategies including cross-massage with ice, proper footwear selection, careful stretching techniques, and anti-inflammatory approaches while cautioning against invasive procedures like steroid injections that might weaken tendons. She discusses promising research on rosemary's potential in Alzheimer's treatment, explaining how carnosic acid activates the NRF2 pathway that controls antioxidant proteins, with researchers developing a more stable chemical analog that reduced inflammation and improved memory in mouse models of Alzheimer's disease. Dr. Dawn provides updates on vaccination recommendations, noting that egg allergy questions are no longer needed before flu vaccines, pneumococcal vaccines are now recommended for all adults over 50, and explaining the small risk of Guillain-Barré syndrome with RSV vaccines compared to the much larger risk of RSV-related deaths. She shares information about a new hypertension risk calculator called PREVENT that reclassifies many patients to lower risk categories, potentially allowing 2.6 million Americans to manage their blood pressure through lifestyle changes rather than medication, particularly benefiting older women who face different risk profiles than men.

Is There Gluten Hiding in Your Thyroid Medication?   Could your thyroid medication be making your Hashimoto's symptoms worse?   If you're working hard to manage your Hashimoto's by avoiding gluten, you might be shocked to learn that some thyroid medications, like generic levothyroxine, could contain gluten and other fillers that sabotage your health. In this episode, Esther, a nurse with over 20 years of experience, uncovers this hidden issue and helps you check your medications and supplements.   In this episode, you'll learn: Why some thyroid medications might be harming your Hashimoto's progress. How to check if your medication contains gluten or other harmful fillers. Practical steps to ensure you're getting safe, high-quality medications and supplements. Hit play now to discover how to protect your health and make informed choices for your Hashimoto's journey!   Find all links on my resource page or keep scrolling here: https://healthwithhashimotos.com/resources/   ABOUT THE PODCAST & ESTHER: The Health with Hashimoto's podcast will help you explore the root causes of your autoimmune condition and discover holistic solutions to address your Hashimoto's thyroiditis. It is hosted by Esther Yunkin, a registered nurse, holistic health educator, and Hashimoto's warrior.   This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional.   Are you trying to find Hashimoto's answers without more trial and error? Here are ways you can find solutions for your health...   Your Path to Health with Hashimoto's is three simple steps.   >> Step One - Hashimoto's Decoded: 10 Thyroid Questions to Ask Your Doctor Your doctor is on your team to give you the best advice he/she can. Ultimately, your action plan is in your hands. These 10 questions will empower you as a patient and advocate for your own health!   >> Step Two - Hashimoto's Decoded: Root Causes Revealed In order to make a difference in your Hashimoto's healing journey, you must know what is causing the problems. This mini course will give you an understanding your own root causes.   >> Step Three - The Holistic Hashimoto's Course Save time and energy as I guide you through the best ways to address your root causes. This is your most streamlined way to take control of your health and feel like yourself again.   >> Holistic Hashimoto's Coaching Sessions are available any time you need to get unstuck in your health and develop an action plan that will work with your current realities of life (time, stress, etc.)   >> Activate your health - LifeVantage The Dual Synergizer turns your Nrf2 pathway back on and increases your own antioxidant production including 300x more glutathione. It also activates your Nrf1 pathway to make more mitochondria (energy.) The Rise & Reset multinutrient system is the best "multivitamin" I've found. The MindBody GLP-1 System gets your body making and maintaining healthy levels of GLP-1 so you can balance your hormones and lose weight.    >> All other supplements - Fullscript is an online store where you can find over 20,000 products to support your wellness goals. Find “Esther's Favorites” under the catalog tab.

Today I am going to share the number 1 root cause I see with my acne clients and how we address it. If you have struggled with your skin and feel at a loss this is the episode for you!   Thank you so much for being here! I am so happy to have you and hope this podcast provides you with the resources you need as you navigate the complicated world of acne, skin health, gut health, wellness and more!  I would love to connect with you over on IG @detoxingwithdani   Links from today's episode: Learn more about NRF2 HERE  Kick up your skin healing with the NRF2 collagen combo HERE Learn more about the Science behind NRF2 HERE Check out Cozy Earth Pajamas and Sheets HERE - dont' forget to use code DETOXING for 40% off    Let's Connect! You can find me on IG @detoxingwithdani or join our private facebook group HERE    MEDICAL & HEALTH DISCLAIMER: The information and other content provided in this podcast, page, or in any linked materials, are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.   If you or any other person has a medical concern, you should consult with your health care provider or seek other professional medical treatment. Never disregard professional medical advice or delay in seeking it because of something that you have heard on this podcast or in any linked materials. If you think you may have a medical emergency, call your doctor or emergency services immediately.

Sulfurophane and health - It is clear now that SFN stands out as a powerhouse phytochemical with profound effects on human health through the pathway of nurclear factor erythroid related 2 (NRF2). It is found abundantly in cruciferous vegetables such as broccoli, broccolini, kale, and brussels sprouts. SFN is a bioactive compound with impressive clinical potential for preventing chronic disease and optimizing cellular health, especially in oxidant impaired/overloaded states. At its core, SFN is a sulfur-rich molecule derived from glucoraphanin, a glucosinolate precursor. The transformation occurs when the enzyme myrosinase, released during the chopping or chewing of cruciferous vegetables, catalyzes the reaction. Interestingly, this enzymatic activation can also be achieved via gut microbiota when raw vegetables are absent from the diet, emphasizing the remarkable adaptability of our biology to source essential nutrients as needed for survival. (Ali et. al. 2023) Nrf2 is a master regulator of cellular defense, orchestrating the production of detoxification enzymes, antioxidants, and other cytoprotective proteins. By activating Nrf2, sulforaphane enhances the body's resilience to oxidative stress, a key contributor to aging, inflammation, and the development of chronic diseases such as cardiovascular disease and diabetes. Studies reveal that sulforaphane also induces Phase II detoxification enzymes, such as glutathione S-transferase, which play a vital role in neutralizing and excreting harmful toxins.

In this episode of The Human Upgrade, Dr. John Gildea and David Roberts from BrocElite join to discuss the powerful benefits of sulforaphane and NRF2 activation. You'll hear about the science behind sulforaphane, a potent compound in broccoli, and how it can boost your health by protecting your cells and enhancing detoxification. Learn why eating broccoli and broccoli sprouts can be a game-changer for your diet and get practical tips on how to incorporate them into your meals. The discussion highlights the role of sulforaphane in supporting gut health and improving resilience to toxins. Dr. Gildea and David Roberts explain the importance of NRF2 activation in promoting longevity and better performance. You'll understand how these mechanisms work to keep your body functioning optimally and how you can leverage them for better health. Tune in to gain valuable insights and actionable advice on enhancing your health with sulforaphane and NRF2 activation!Timestamp Highlights: (00:00:00) Introduction: Benefits of sulforaphane and NRF2 activation. (00:01:04) Are Bodybuilders the Edgiest Biohackers? (00:02:10) Benefits of Broccoli and Sulforaphane (00:04:23) Isothiocyanates and Thyroid Function (00:10:57) Longevity and Performance Impacts of NRF2 (00:18:20) Resilience Against Toxins (00:24:57) Sulforaphane and Autism (00:31:08) Anti-Inflammatory Effects of Sulforaphane (00:40:52) Gut Health and Microbiome (00:45:58) Autophagy and Cellular Health (00:55:57) Dosage and Safety (01:02:00) Closing Thoughts Sponsors: Go to Mara-Labs.com/Dave and save up to 28% off your order. Our Place | Go to FromOurPlace.com and use the code DAVE for 10% off your order. ZBiotics | Go to Zbiotics.com/Dave for 15% off your first order. Resources: Go to Mara-Labs.com/Dave and save up to 28% off your order. Follow Mara Labs on Instagram: @themaralabs Twitter: @TheMaraLabs Dave's Linktree: https://linktr.ee/daveasprey Dave Asprey's Book ‘Smarter Not Harder' is out now: https://daveasprey.com/books Follow Dave on Instagram: @Dave.Asprey Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com/ Own an Upgrade Labs: https://ownanupgradelabs.com/ See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.