Podcasts about mthfr

Everyone thinks testosterone is bad for your heart, but with 10,000 receptors for it in the heart alone, I'd argue low testosterone is the real cardiovascular risk. In this solo Q&A, I answer the 11 questions you ask me most, from TRT and vitamin D to folate and my morning breathwork. It all comes back to one thing: you're not broken, you're deficient, and that's fixable. CLICK HERE TO BECOME GARY'S VIP!: ⁠https://bit.ly/4ai0Xwg⁠  Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: ⁠http://bit.ly/4kek1ij⁠  AION: “ULTIMATE10” FOR 10% OFF: ⁠https://bit.ly/4h6KHAD⁠  AIRES: “ULTIMATE20” FOR 20% OFF: ⁠https://bit.ly/4a3Duze⁠  BAJA GOLD: “ULTIMATE10” FOR 10% OFF: ⁠https://bit.ly/3WSBqUa⁠   BODYHEALTH: “ULTIMATE20” FOR 20% OFF: ⁠http://bit.ly/4e5IjsV⁠  COLD LIFE: THE ULTIMATE HUMAN PLUNGE: ⁠https://bit.ly/4eULUKp⁠  CYMBIOTIKA: “BRECKACYM30” FOR 30% OFF: ⁠https://bit.ly/4tjyluP⁠   GENETIC METHYLATION TEST (UK ONLY): ⁠https://bit.ly/48QJJrk⁠  GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9⁠  GOPUFF: GET YOUR FAVORITE SNACK!: ⁠https://bit.ly/4obIFDC⁠  H2TABS: “ULTIMATE10” FOR 10% OFF: ⁠https://bit.ly/4hMNdgg⁠  HEALF: 10% OFF YOUR ORDER: ⁠https://bit.ly/41HJg6S⁠  PEPTUAL: “TUH10” FOR 10% OFF: ⁠https://bit.ly/4mKxgcn⁠  SNOOZE: LET'S GET TO SLEEP!: ⁠https://bit.ly/4pt1T6V⁠  WHOOP: JOIN & GET 1 FREE MONTH!: ⁠https://bit.ly/3VQ0nzW⁠  Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: ⁠https://bit.ly/3RPQYX8⁠  Podcasts: ⁠https://bit.ly/3RQftU0⁠  Connect with Gary Brecka Instagram: ⁠https://bit.ly/3RPpnFs⁠  TikTok: ⁠https://bit.ly/4coJ8fo⁠  X: ⁠https://bit.ly/3Opc8tf⁠  Facebook: ⁠https://bit.ly/464VA1H⁠  LinkedIn: ⁠https://bit.ly/4hH7Ri2⁠  Website: ⁠https://bit.ly/4eLDbdU⁠  Merch: ⁠https://bit.ly/4aBpOM1⁠  Newsletter: ⁠https://bit.ly/47ejrws⁠  Ask Gary: ⁠https://bit.ly/3PEAJuG⁠  Timestamps 00:00 Intro of show 01:56 Is Gary Brecka a real doctor? 03:50 Hormone replacement therapy explained 04:42 Testosterone and your heart 05:22 Which diet actually extends life 06:24 What Gary eats in a day 06:46 The daily morning drink and stack 08:42 How to do a 3-day water fast 09:14 The MTHFR gene mutation 10:54 Vitamin D3 dosing and K2 11:59 Folate versus folic acid 12:50 Morning and nighttime breathwork 15:48 Weight loss and the 30 30 30 method 17:02 Getting tests outside the U.S. 17:49 Pick one habit to start today  Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

Have you ever noticed how two women fifteen years apart can seem worlds apart in energy, while two women the same age can be aging in completely different directions? In this episode of The Art of Living Well Podcast®, Marnie and Stephanie unpack what they call the midlife health dashboard: the metrics that actually predict how well you're aging, beyond the number on a biological age test. They share their own results from two different biological age tests, including a jarring 16-year gap between the two, and walk through what's actually within your control. Biological age testing has exploded in popularity, with people online sharing scores and spending real money to find out if they're aging faster or slower than their birth certificate says. Marnie and Stephanie have both taken these tests themselves, and they break down what the scores actually mean, what they missed, and why the number matters far less than the daily habits behind it. Whether you've taken a biological age test, are curious about one, or just want a practical way to think about aging well, this episode gives you a place to start today. Key Takeaways: •Biological age tests compare you to other people who took that same test, often a health-conscious group, not the general population •Genetic testing can also reveal your MTHFR status and ApoE genotype, which may be more useful day to day than the biological age score itself •Getting up off the floor without using your hands is one of the simplest predictors of long-term mobility •Walking pace and small daily movement snacks measurably affect how well you age, not just how far you walk •Deep sleep, not just total hours, is one of the most overlooked levers for energy and recovery in midlife •Most women are still under-eating protein, and it shows up in blood work, energy, and cravings •Chronic stress and time spent in fight-or-flight directly affects your biological age, not just how you feel day to day •You don't need a lab test to start improving your health dashboard, an honest self-score across a few key areas is a good place to begin Episode Breakdown with Timestamps: 00:00 Why Two Women 15 Years Apart Can Age So Differently 00:59 Welcome Back: Introducing the Midlife Health Dashboard 01:28 What Biological Age Actually Measures 01:55 Stephanie's Biological Age Test Results, Explained 04:34 Marnie's Two Test Results: One Said 54, One Said 38.6 07:37 The MTHFR Gene and Why Methylation Matters 08:49 Genes Aren't Destiny: A Quick Note on Epigenetics 09:30 Metric: Muscle and Functional Strength 10:21 The "Can You Get Off the Floor" Longevity Test 10:49 Book Rec: The New Fit With Aaron Leventhal (Episode 284) 11:32 Metric: Walking, Movement Snacks, and Pace 13:49 Metric: Sleep and the Midlife Wake-Up Spiral 15:26 Sleep Trackers Worth Trying: Aura Ring vs. Whoop 16:30 Chasing Deep Sleep: What Actually Moved the Needle 17:44 Metric: Stress, the Nervous System, and a PEMF Mat Experiment 19:52 Metric: Protein, and Why Most Women Are Under-Eating It 22:15 Does Everyone Need to Take a Biological Age Test? 23:02 Metric: Connection and Purpose 23:59 Metric: Getting Out of Fight-or-Flight 24:59 Build Your Own Health Dashboard: Score Yourself 25:08 How Old Do You Actually Feel? 28:16 What We'd Tell Our Kids Now 29:21 Share Your Biological Age Results With Us 29:45 Join the Fall Vitality Reboot, Starting September 27 Resources and Links: Episode 267, The New Fit with Aaron Leventhal Episode284 with Danny King (Lifetime) on VO2 max  Episode 319 on Community and Longevity for Midlife Women  Episode317 Design a life you love with the "big ass calendar" co-founder  Feeling tired, inflamed, or stuck in a cycle of cravings? Join our 7-Day Fall Vitality Reboot starting September 27 and discover how much better you can feel with simple daily habits and a supportive community beside you every step of the way. Click here to save your spot: https://l.bttr.to/fNSbn Subscribe to our Substack to get episode updates, wellness tips, and personal reflections from Marnie & Stephanie delivered straight to your inbox. Grab your free Midlife Travel Resilience Checklist here. If you love the show and want to support what we're building, consider a paid subscription for $30 annually. https://theartoflivingwell.substack.com/ Follow & Connect: Instagram: https://www.instagram.com/theartofliving_well/ YouTube: https://www.youtube.com/@theartoflivingwellpodcast LinkedIn: https://www.linkedin.com/company/the-art-of-living-well-podcast/ TikTok: https://www.tiktok.com/@theartoflivingwel/ Spotify: https://open.spotify.com/show/4gym3jOPdSHwrpM1BmxyJz Apple Podcasts: https://podcasts.apple.com/us/podcast/the-art-of-living-well-podcast/id1482050468 Connect with Your Hosts: Marnie Dachis Marmet: https://www.instagram.com/zenfullifecoaching  Stephanie May Potter: https://www.instagram.com/stephaniemaypotter/  

On this episode of Vitality Radio, Jared explores a heartbreaking and highly publicized case involving postpartum mental health struggles, multiple psychiatric prescriptions, and the devastating consequences that followed. Using publicly documented court records and prescription timelines, he examines the challenges of polypharmacy, fragmented care, and the importance of patients actively participating in their own health decisions. Jared also discusses research surrounding mental health, the gut-brain connection, nutrient status, methylation, and other foundational factors that may influence emotional well-being. Drawing from his wife Jen's personal journey, he shares a message of hope and resilience for those facing anxiety, depression, or other mental health challenges. This episode encourages listeners to ask questions, seek understanding, and explore a more comprehensive approach to supporting both body and mind.Additional Information:#264: Emotional Vitality: Jen's Story Part 1 - From Addiction and Mental Illness to Vitality#423: Emotional Vitality: Jen's Story Part 2 - Rebalancing Mind and Body Through Supplementation#438: Emotional Vitality: Jen's Story Part 3 - Weaning Off of Pharma#457: Emotional Vitality: Jen's Story Part 4 - How Changing Your Mindset Can Change Your Life #505: Emotional Vitality: Jen's Story Part 5 - The Impact of Diet on Mental Health and Physical Pain#601: Folate vs. Folic Acid and the Importance of B12 and B6 as the Methylation TeamVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.This podcast is produced by DrTalks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/

Dr. Theoharis Theoharides is back, and this time we got into the stuff that has been all over the news. Leucovorin. Tylenol. Benadryl. Underneath the headlines there is actual science, and Dr. Theo walks through what inflammation, mast cells, and folate really have to do with our kids. The throughline is simple. A diagnosis is a label, not a treatment plan, and there is measurable biology underneath that label that most workups never look at. Dr. Theo holds five degrees from Yale, spent 37 years at Tufts, has published more than 500 peer reviewed papers, and was the first researcher to connect mast cells to autism. He now runs the Center of Excellence for Neuroinflammation Research in Florida. In this episode: - What a mast cell actually is, and why the ones in the brain matter- Propionic acid, and why it is sitting in most kids' cereal- The four things he wants every autism workup to cover- The folate test most kids never get, and why normal bloodwork can still be wrong- A 30-second test you can run at your kitchen table tonight- Why constipation changes behavior more than almost anything he has seen- What to do when your pediatrician refuses to order a test- How to tell a real supplement from an expensive one- Twenty years of autism fads, and why stem cells do not work- When to stop something that is not working His most honest moment: "I hate the term therapeutic because I don't know what I'm treating." His best one: "The brain is working. The fact that they don't speak doesn't mean anything." RESOURCESFRAT, the Folate Receptor Autoantibody Test. Must be ordered by a physician.MTHFR gene analysis.RBC folate and RBC B12, to see what is getting inside the cells.Flat abdominal X-ray, when behavior spikes and nobody can explain it. FIND DR. THEOdrtheoharides.com, which has an intake form.Instagram: @drtheoharidesHe sees patients in Fort Lauderdale the third week of each month, adolescents and adults only. FIND ROBtheautismdad.comThe book, So Your Child Was Just Diagnosed with Autism, is out December 29. Preorder at theautismdad.com/book/ DISCLAIMERDr. Theoharides is a physician and PhD pharmacologist with five degrees from Yale and more than 500 peer reviewed publications. This conversation is education, not personalized medical advice. He names specific tests, supplements, medications, and doses, and he gives them as clinical context. The right number for any individual child depends on age, weight, and labs. Do not start, stop, or change anything based on a podcast. Talk to your child's doctor.

Our dear friends invited us to an event this weekend in LA… they are partnering with Gary Brecka to build Ultimate Longevity Centers which will bring treatments and testing that just hasn't been easily accessible before now. I believe the way we look at aging is outdated and I'm going to share the biggest take aways I got from his on stage message and chatting with him one on one. We are talking about very practical starting points and Gary Brecka's actual morning health routine. Stop waiting until something is wrong to start taking care of your body. We have been taught this idea that getting older automatically means getting weaker, having less energy, gaining weight, losing muscle, sleeping worse, becoming more anxious, needing more medications and eventually developing all of the diseases that "run in our family." Gary challenges a lot of that thinking. His message is essentially… What if we became obsessed with keeping our bodies functioning incredibly well for as long as possible? What if instead of asking, "How do I treat disease once I have it?" we asked, "How do I create a body that is incredibly difficult for disease to thrive in?" And then there's the longevity piece that completely fascinates me. Gary believes we're entering a period where medicine, AI, biological data and longevity research are going to advance so rapidly that lifespan could look radically different in the future. Maybe 120. Maybe beyond. We don't know. But what we do know is that we need to keep ourselves healthy enough NOW to benefit from whatever becomes possible later. So today's episode is about doing the things that give you the strongest, healthiest, most capable body possible. I've been listening to Gary Brecka talk about health, longevity, anxiety, genetics, sleep, sunlight, oxygen, muscle, bloodwork and what he believes is coming next in longevity science. THE BIG IDEA: YOUR HEALTH IS BUILT EVERY DAY One of my biggest takeaways from Gary is that health isn't something we deal with when there's a problem. It's something we're building every single day. Your sleep last night matters. What you do when you wake up matters. Whether you move your body matters. Whether you maintain muscle matters. Your metabolic health matters. Your stress matters. Your relationships matter. Your nutrition matters. Your environment matters. And individually, none of these things feels life-changing. But repeated for years and decades… they become your life. Gary describes his routine as simple, portable and repeatable. I LOVE that. Because the best health routine isn't the $100,000 biohacking setup. It's the one you'll actually do every day. HABIT #1: HYDRATE BEFORE YOU DO ANYTHING ELSE Gary starts his morning with water and minerals. One version of his routine is a large glass of room-temperature water with mineral salt and sometimes lemon. His current routine also frequently includes mineral salt, hydrogen water and essential amino acids. Wake up and hydrate. You've just spent roughly eight hours without drinking anything. Don't make coffee your first liquid of the day. Put water next to your bathroom sink. Put it next to your coffee machine. Make it automatic. Gary likes mineral salt because sodium and other minerals participate in fluid balance and normal nerve and muscle function. HABIT #2: GET OUTSIDE FIRST THING Gary says to get outside within the first part of your morning and get natural outdoor light into your eyes. His routine generally calls for about 10 minutes outside. Morning light helps tell your brain: It's daytime. Start the clock. Light is one of the strongest environmental signals for the circadian system. Properly timed morning light can shift circadian timing earlier and increase daytime alertness. And I love thinking of sleep this way: Your good night's sleep starts in the morning. We tend to think sleep health starts when we crawl into bed. But your body has been receiving signals all day telling it when to be awake and when to prepare for sleep. HABIT #3: BREATHE ON PURPOSE Gary talks about oxygen constantly. His personal morning practice has included three rounds of deep breathing followed by breath holds. And this connects to another thing we've been talking about: Anxiety. I love the idea that when you feel anxious, you shouldn't immediately decide: "I'm an anxious person." Anxiety is a state your nervous system is experiencing. Sometimes your thoughts are driving your physiology. And sometimes your physiology can amplify anxious thoughts. Either way, changing the physical state can sometimes help change the mental state. Research on structured breathwork has found modest improvements in stress and anxiety, although it isn't a cure-all and the quality of studies varies. HABIT #4: GIVE YOUR BRAIN SILENCE Gary often combines his morning breathing with quiet, gratitude and reflection. He has described sitting quietly for around 10 minutes, looking toward the horizon or closing his eyes and thinking about gratitude. (PodScripts (https://podscripts.co/podcasts/the-ultimate-human-with-gary-brecka/246-gary-brecka-answers-googles-most-searched-questions-on-his-diet-wellness-and-lifestyle?utm_source=chatgpt.com)) Think about how different this is from what most of us do. Eyes open. Phone. Email. Instagram. News. Text messages. Stress. Other people's priorities. And we wonder why we feel overstimulated. TRY THIS: Before consuming everybody else's thoughts… Have some of your own. What am I grateful for? What matters today? Who needs me today? How do I want to feel today? What is actually important? PRACTICAL VERSION: Five minutes. That's it. No phone. No podcast. No input. Just quiet. HABIT #5: USE CONTROLLED DISCOMFORT Cold exposure is another major Brecka habit. If he has access to a cold plunge, he uses it. When traveling, he has said a cold shower works too. But I think there is a bigger lesson here than whether everybody needs to buy a cold plunge. Stop designing your entire life around comfort. Human beings are unbelievably adaptable. Exercise is stress. Heat is stress. Cold is stress. Fasting is stress. Challenging your brain is stress. The key is appropriate amounts of stress followed by recovery. HABIT #6: MOVE EARLY Gary includes movement in his morning routine. But here's what I love: It doesn't need to be a full workout. Walk. Stretch. Squat. Lift. Do yoga. Go outside. Movement tells your body: We're alive. We're using this machine today. And then keep moving after the morning is over. One exceptionally practical habit is walking after meals. Instead of finishing dinner and immediately sitting on the couch… WALK FOR 10 MINUTES. Moving skeletal muscle after eating can help the body handle glucose. You don't need workout clothes. You don't need a gym. You don't even need to sweat. Walk around your neighborhood. Walk your dog. Walk while you're on a phone call. ONE OF THE EASIEST HEALTH RULES: Eat → walk. HABIT #7: BUILD MUSCLE LIKE YOUR FUTURE DEPENDS ON IT This is where I think longevity conversations get really practical. MUSCLE IS NOT JUST ABOUT LOOKING GOOD. Maintaining muscle becomes increasingly important as we age. Resistance training is one of the most powerful non-drug strategies available for preserving and building skeletal muscle. Losing muscle eventually affects: strength balance mobility independence your ability to recover from illness your ability to do normal life You're not building your 2026 body. You're building your 2056 body. HABIT #8: PRIORITIZE PROTEIN AND REAL FOOD- avoid processed foods Gary emphasizes protein and essential amino acids because preserving lean tissue is a major part of his longevity philosophy. The research strongly supports resistance training for preserving muscle, while evidence regarding how much additional benefit comes from protein supplementation specifically is more mixed. HABIT #9: PROTECT YOUR METABOLIC HEALTH I think this deserves WAY more attention. We obsess over weight. Gary talks much more about metabolic health. There is a difference. Weight is one number. Metabolic health includes things like: blood glucose insulin sensitivity blood pressure blood lipids waist circumference fitness body composition Instead of only asking: "How much do I weigh?" Ask: "How well is my body functioning?" Someone can lose weight while losing muscle. Someone can be thin and still have poor metabolic health. PRACTICAL HABITS: Strength train. Walk. Walk after meals. Eat mostly whole foods. Get enough sleep. Maintain healthy body composition. Reduce constant snacking if it isn't serving you. Know your basic health numbers. THE GOAL ISN'T SKINNY. The goal is metabolically capable. HABIT #10: TEST… DON'T JUST GUESS This might be one of my favorite parts of Brecka's philosophy. Stop guessing about everything. If you're exhausted all the time… investigate. If you're unusually anxious… investigate. If your sleep has suddenly changed… investigate. If your energy has disappeared… investigate. If your hormones feel completely different… investigate. If you feel awful despite doing "everything right"… investigate. Don't immediately decide: "I'm getting old." "This runs in my family." "I'm just an anxious person." "My metabolism sucks." "This is just how I am." ASK BETTER QUESTIONS. Could something modifiable be contributing? sleep nutrient deficiencies thyroid function iron status medications hormones metabolic health stress alcohol caffeine environment psychological health This does NOT mean ordering every exotic test on the internet. It means becoming curious about your own biology. HABIT #11: DON'T TURN ANXIETY INTO YOUR IDENTITY This is worth repeating because I think this is such an important mental shift. Instead of: "I AM anxious." Try: "I'm experiencing anxiety." Those are very different statements. One is an identity. One is a temporary condition worth investigating. Gary's message leans heavily toward investigating biology. He talks about things like methylation pathways and MTHFR. There are legitimate genetic influences on anxiety. But anxiety is complex. Research suggests anxiety disorders arise through a combination of genetic vulnerability and environmental influences, not one single "anxiety gene." (PubMed (https://pubmed.ncbi.nlm.nih.gov/15699295/?utm_source=chatgpt.com)) So I would approach it from ALL DIRECTIONS: Calm the body. Investigate the biology. Work on the thoughts. Breathwork. Sleep. Exercise. Less overstimulation. Healthy relationships. Therapy when needed. Medical evaluation when something feels physiologically off. Nutrition. Less caffeine when appropriate. Time outdoors. Don't choose between: "It's psychological." or "It's biological." It can be both. HABIT #12: GENETICS ARE INFORMATION… NOT ALWAYS DESTINY This is another Gary Brecka concept that I think is incredibly empowering when we phrase it accurately. People say: "Diabetes runs in my family." "Anxiety runs in my family." "Heart disease runs in my family." "Autoimmune disease runs in my family." And we can start thinking: Well… I guess that's coming for me too. But genetics often represent susceptibility rather than certainty. Your genes can increase risk. Your environment can increase or decrease risk. Your behaviors matter. Your metabolic health matters. Your exposures matter. Your entire biological environment matters. So instead of thinking: "My family gets this disease." Think: "I may have inherited a vulnerability. What parts of that vulnerability can I modify?" THAT is empowering. Important distinction: Some diseases absolutely are caused by inherited genetic mutations. So we should not say: "Genetic diseases aren't real." They absolutely are. The better message is: Genes can load the gun. They don't always pull the trigger. And with many complex chronic diseases, what ultimately happens involves an interaction between genetics and environment. HABIT #13: STOP THINKING OF SLEEP AS LOST PRODUCTIVITY Sleep is when your body gets to repair. And Brecka's evening routine reflects this. He emphasizes regular sleep, reducing stimulation late at night and setting up the next morning by protecting the night before. My favorite way to think about sleep: Tomorrow starts tonight. Stop trying to squeeze another hour out of your day if it destroys tomorrow. Decide when you're going to bed BEFORE you're tired. Dim things down. Get off your phone. Stop working. Let the nervous system receive a signal that the day is ending. Pick a bedtime and protect it the same way you'd protect an important meeting. NOW LET'S TALK ABOUT LIVING TO 120 The speed of advancement is changing. AI can analyze enormous amounts of biological data. Diagnostics are improving. Scientists are studying the actual biology of aging rather than treating aging purely as an unavoidable decline. Researchers are investigating cellular senescence, epigenetics, regenerative medicine and other mechanisms associated with biological aging. Gary believes these developments could eventually change human lifespan dramatically. And his argument is essentially: Stay alive and stay healthy long enough to benefit from what's coming. That hit me HARD. Because imagine being 75 in the future… But instead of arriving at 75: metabolically sick weak frail sedentary cognitively struggling carrying multiple preventable chronic illnesses You arrive: strong metabolically healthy active engaged cognitively sharp sleeping well maintaining muscle surrounded by people you love THAT is the bridge. Not: "How do I live forever today?" But: "How healthy can I be when tomorrow's medicine arrives?" DON'T JUST CHASE LIFESPAN. CHASE HEALTHSPAN. I don't want to simply exist until I'm 120. I want to LIVE. I want to: travel walk everywhere lift my suitcase play with grandchildren hike swim think clearly learn new things have great conversations have energy be independent laugh have purpose wake up excited THAT is longevity. Not adding years at the end where you can't live. Adding life to the years. WHAT SHOULD WE ACTUALLY DO RIGHT NOW? If you took this entire episode and boiled it down into a daily longevity checklist… MORNING Hydrate. Get outside. Get natural morning light. Breathe intentionally. Spend a few minutes in quiet. Think about gratitude. Move your body. Use cold exposure if you enjoy it and it's appropriate for you. Don't immediately flood your brain with stress. DURING THE DAY Eat nutrient-dense real food. Prioritize protein. Strength train consistently. Walk. Walk after meals. Stay metabolically healthy. Maintain muscle. Build meaningful relationships. Have purpose. Keep learning. Get outside. NIGHT Stop eating mindlessly late into the evening. Reduce stimulation. Get off the phone. Give yourself a predictable bedtime. Sleep. THROUGHOUT YOUR LIFE Know your numbers. Do appropriate preventive screening. Investigate symptoms rather than ignoring them. Don't automatically assume something is "just aging." Don't automatically assume family history means destiny. Continue learning as science changes. Protect your muscle. Protect your metabolism. Protect your brain. Protect your relationships. Protect your sleep. THE SIMPLEST VERSION OF EVERYTHING GARY BRECKA IS SAYING 1. Get sunlight. 2. Breathe. 3. Hydrate. 4. Move. 5. Build muscle. 6. Eat real nutrient-dense food. 7. Protect your metabolism. 8. Sleep like it matters. 9. Challenge your body sometimes. 10. Investigate problems instead of simply accepting them. 11. Don't confuse genetic risk with guaranteed destiny. 12. Don't turn anxiety into your identity. 13. Build relationships and a life that gives you purpose. 14. Stay unbelievably healthy while longevity science continues advancing. And maybe most importantly… DON'T WAIT UNTIL YOU'RE SICK TO BECOME INTERESTED IN YOUR HEALTH. I learned that every single thing that gives me the best chance of being healthy at 120 also gives me a better life at 45. Getting sunlight tomorrow morning makes tomorrow better. Sleeping tonight makes tomorrow better. Building muscle makes this decade better. Eating well makes today better. Getting outside makes today better. Putting my phone down makes today better. Managing anxiety makes today better. Having people I love around me makes today better. So this isn't really an episode about trying to cheat death. It's about refusing to sleepwalk through your health. Your body is the vehicle that carries you through every single experience you're hoping to have. Every trip. Every adventure. Every business idea. Every dinner. Every workout. Every moment with your kids. Every future grandkid. Everything. So take ridiculously good care of it. And instead of looking at aging and thinking… "Well, I guess everything starts going downhill from here…" What if we thought completely differently? What if our goal was: I want to be stronger next year. Healthier next year. More metabolically healthy next year. More informed next year. More capable next year. And then do it again. And again. And again. For decades. Let's make the goal to be fully alive for as much of it as humanly possible. That's the health lesson I'm taking from Gary Brecka. Don't wait for the future of longevity medicine. Build the kind of body today that's ready for it.

Menopause Mastery | Menopause and Genetics: Why Your DNA Test Might Be Missing the Real Story | Ep. 292 with Dr. Tracey Steady-Hardcastle 

This episode answers one of the questions raised in the most recent Q&A episode on Sigma Nutrition Premium.  The full episode includes the following questions: Fiber: Independent effect or proxy for healthy foods? Exposure frequency for matched dose of red meat MTHFR gene mutations and 5-MTHF Typical fish oil supplements vs pharmaceutical-grade products Health impacts of saturated fat in coconut products Do I need to consume whole grains? Could the increasing use of AI pose a threat to doing rigorous science? To listen to the entire episode (plus the back catalogue of all Premium-exclusive episodes) become a member of Sigma Nutrition Premium. For episode info and mentioned research go to the episode page here.

Methylation is a chemical process running billions of times per second inside your body — and when it slows down, you feel it as fatigue, low mood, brain fog, and hormone symptoms. Nurse Doza breaks down what methylation actually does, why the MTHFR gene variant makes the cycle run less efficiently, why folic acid is the wrong form of folate if you carry it, and the four steps that support your methyl donor supply. FEATURED PRODUCT Bliss (Mood Booster) — $129 Bliss is a lemon-flavored daily stick pack built around TMG (trimethylglycine) — a naturally occurring methyl donor. It is formulated to support the biochemical reactions that require methyl groups: neurotransmitter synthesis and healthy mood, the conversion of homocysteine to glutathione, and liver health.* If the episode described you — normal labs, still running on empty — Bliss is the piece that feeds the cycle directly instead of asking your genetics to do the conversion work.

Managing High Homocysteine with MTHFR Variants and the Role of Vitamin C in Brain Aging: Registered dietitian nutritionist Leyla Muedin discusses MTHFR genetic variants (C677T and A1298C), their links to impaired methylation, homocysteine, SAMe, mood issues, migraines, vitamin deficiencies, and pregnancy complications, noting many people are asymptomatic and some feel worse on methylated B vitamins and do better on standard formulations. Responding to a listener with C677T, high homocysteine, and borderline methylmalonic acid, she reviews optimal homocysteine targets and outlines other causes of elevated homocysteine such as hypothyroidism/subclinical hypothyroidism, kidney failure, obesity, hypertension, diabetes, smoking, inactivity, and medications (atorvastatin, methotrexate, fenofibrate). She suggests checking these factors, considering absorption issues (intrinsic factor) for B12, and trialing SAMe and more trimethylglycine, with possible pharmacologic folate if needed. She then summarizes an observational Japanese study (n=2,044 adults >64) linking lower plasma vitamin C to reduced gray matter and weaker default mode network connectivity, and notes diet and blood sugar can affect vitamin C status.

You've been told your whole life that your condition is genetic, that it runs in your family, and you're stuck managing it forever, but I'm telling you that with rare exceptions, we don't inherit disease at all. What we inherit is an inability to refine a raw material, which creates a deficiency, and that deficiency is what shows up as the symptom you've been calling a disease. Find what your body can't make on its own, put it back, and watch what happens.  CLICK HERE TO BECOME GARYS VIP!: ⁠https://bit.ly/4ai0Xwg⁠ Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKpCYMBIOTIKA: "BRECKACYM30" FOR 30% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: ⁠https://bit.ly/3RPQYX8⁠ Podcasts: ⁠https://bit.ly/3RQftU0⁠ Connect with Gary Brecka Instagram: ⁠https://bit.ly/3RPpnFs⁠ TikTok: ⁠https://bit.ly/4coJ8fo⁠X: ⁠https://bit.ly/3Opc8tf⁠ Facebook: ⁠https://bit.ly/464VA1H⁠ LinkedIn: ⁠https://bit.ly/4hH7Ri2⁠ Website: ⁠https://bit.ly/4eLDbdU⁠ Merch: ⁠https://bit.ly/4aBpOM1⁠ Newsletter: ⁠https://bit.ly/47ejrws⁠ Ask Gary: ⁠https://bit.ly/3PEAJuG⁠ Timestamps 00:00 - Intro of Show 01:04 - Gary takes the stage 02:39 - Going back to the basics of human physiology 04:22 - The two bold promises and mortality data 05:04 - Why life insurers predict death to the month 06:03 - The myth that disease is genetically inherited 08:11 - Reading deficiencies: tired, sore, brain fog, anxiety 09:53 - Circadian rhythm and bookending your sleep 12:11 - Fasting as a jet lag superpower 13:16 - Live breath work session 16:58 - The second bold promise 17:53 - The methylation chart explained 19:18 - MTHFR and the anxiety-gut link 22:27 - Homocysteine, creatine, and methyl donors 25:31 - Why targeted supplementation beats random stacks 26:22 - Reading a supplement label for cofactors 28:41 - The genetic methylation test 30:06 - Q&A: fibroids, insulin resistance, the Dutch test 33:03 - Q&A: LDL, triglycerides, and Lp(a) 39:58 - Q&A: high cortisol and hormone ratios 43:58 - Q&A: Hashimoto's, the Dutch test, and the COMT gene 47:18 - Q&A: Asperger's and mood numbness 51:18 - Q&A: anaphylaxis and mast cell activation 57:20 - Q&A: vitiligo and red light therapy 59:59 - Q&A: low T3, the liver, and selenium 1:05:28 - Q&A: IBS and the pace of the gut Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.  Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

The new vaccine schedule recommendationsMy urologist is giving me grief that my vitamin D level is too highWhich nattokinase do you recommend to treat long covid?Is the vitamin K in your bone protocol different from the heart protocol?What about methylated B vitamins for brain vs. heart health?

Three of the most common — and most misunderstood — questions I get in almost every explant consultation: What does "en bloc" actually mean? Why don't I use surgical drains anymore? And what's really going on with forever chemicals, mold toxins, and heavy metals before surgery? In this episode, I break down:

In this episode of The Performance Medicine Show, Dr. Rogers answers YOUR health and wellness questions!

Have you ever opened your supplement cabinet and thought, what have I done? Half a bottle of this, half a bottle of that, and you genuinely cannot remember why you bought most of it.If that's you, keep reading, because this episode is going to feel like a permission slip.I sat down with Lori Hammer, who works with moms on nervous system regulation, and we went back to some foundations we haven't touched in a while. The real, unglamorous, actually-works version. The kind that don't involve a $300 device or a fridge full of tinctures. She said something in this conversation that stopped me mid-sentence. She said the biggest thing keeping smart, well-educated women stuck isn't lack of information. It's that they keep trying new things instead of sticking with the basics long enough to see them work.I have absolutely been that woman.Here's what we cover:What nervous system regulation actually means, beyond feet up the wall and deep breathing (helpful, sure, but there's so much more underneath)Why your symptoms shift so dramatically between the first and second half of your cycle, and what's happening in your brain when that happensThe connection between screen time, sleep, and the sudden rise in adult women getting diagnosed with ADHD in their thirtiesWhat Lori does instead of blood work or urine testing, and why her clients feel the difference almost immediately The biohacking trend she watches backfire again and again, and who it's actually meant forWhy the urge to shop, hoard supplements, or chase the next fix might have way less to do with willpower and way more to do with your nervous systemOkay, let's talk about the cycle piece for a second, because I think this is the part that will make you feel the most seen.Lori and I talked about how the first half of the month tends to feel manageable, sometimes even great, and then the second half hits and suddenly you're snapping at your kids and wondering who just took over your body. She sees this constantly with the women she works with. Career going fine. Kids taken care of. Everything looking put together from the outside. And underneath all of it, she says, women are twisted up, forgetting things, hiding that they're forgetting things, wearing what she calls a really good mask.That good week or two you get every month, where you finally feel on top of it? She pointed out that it's not false. It's true, you really can hold it all together during that window. But it also tricks you into overcommitting, because you think you've cracked the code. Then the crash hits harder because you built more on top of an already shaky foundation.We also got into something I don't think gets talked about enough, which is how much of the "nervous system content" flooding your feed right now might actually be adding to the problem. Red light therapy, cold plunging, the latest stress supplement, the wearable that tracks everything. Lori's take was refreshingly blunt. None of these things are bad on their own, but if you're layering them on top of a body that doesn't have the basics in place, you're just adding more stress your system has to process. She said it plainly: sometimes these things are sandpaper to the nervous system.And if you've ever gotten an MTHFR result back and thought, this is it, this explains everything? She sees that a lot too, and gently, she doesn't think it's usually the whole story.What I really want you to sit with is this idea that your nervous system has to feel safe enough to actually let go of things, whether that's stored toxins, extra weight, or old patterns. If your body is still in overdrive, it will hold on tight no matter how many supplements or IVs you throw at it. Lori sees this constantly with clients who have spent thousands trying to detox while their nervous system is still sounding the alarm the whole time.There was a moment near the end where Lori said something I haven't stopped thinking about. A lot of the women she works with haven't tried everything; they just think they have. What they actually need is to pick one foundational piece, whatever's missing right now, and build from there instead of adding twenty seven things at once.If you've been in that cycle of trying, stopping, trying something new, and quietly wondering why nothing sticks, this one is going to feel like someone finally explaining the thing you couldn't quite put words to.So here's my challenge for you this week. Before you add one more thing to your routine, take a piece away instead. Pick the one thing that's felt like sandpaper lately and set it down. See what your body does when you give it room to breathe instead of one more thing to process.CONNECT WITH LAURIE:WebsiteInstagramNEED HELP FIXING YOUR HORMONES? CHECK OUT MY RESOURCES:Breakfast GuideNourish Tracker - Discount code: HAPPILYHORMONALBook a FREE Hormone Strategy Call with meGrab your Happily Hormonal Quick Start GuideHormone Imbalance Quiz - Find out which of the top 3 hormone imbalances affects you most!Join Nourish Your Hormones Coaching for the step-by-step and my eyes on YOUR hormones for the next 4 months.Send us a text with episode feedback or ideas! (We can't respond to texts unless you include contact info but always read them)FREE Podcast Training - Simply Nourished CyclesDon't forget to subscribe, share this episode, and leave a review. Your support helps us reach more women looking for answers.Disclaimer: Nothing in this podcast is to be taken as medical advice, please take informed accountability and speak to your provider before making changes to your health routine.This podcast is for women and moms to learn how to balance hormones naturally in motherhood, to have pain-free periods, increased fertility, to decrease PMS mood swings, and to increase energy without restrictive diet plans. You'll learn how to balance blood sugar, increase progesterone naturally, understand the root cause of estrogen dominance, irregular periods, PCOS, insulin resistance, hormonal acne, post birth-control syndrome, and conceive naturally. We use a pro-metabolic, whole food, root cause approach to functional women's health and focus on truly holistic health and mind-body connection.If you listen to any of the following shows, we're sure you'll like ours too! Pursuit of Wellness with Mari Llewellyn, Culture Apothecary with Alex Clark, Found My Fitness with Rhonda Patrick, Just Ingredients Podcast, Wellness Mama, The Dr Josh Axe Show, Are You Menstrual Podcast, The Model Health Show, Grounded Wellness By Primally Pure, Be Well By Kelly Leveque, The Freely Rooted Podcast with Kori Meloy, Simple Farmhouse Life with Lisa Bass

In this episode, I tackle one of the most talked-about topics in the functional and alternative medicine world: MTHFR. So many women have been told that this one gene is the reason behind their migraines and other chronic symptoms, but the real story is much more nuanced than that. I break down what MTHFR actually does, why I believe the conversation around it has gotten distorted, and why the bigger issue may have more to do with synthetic folic acid, digestion, and the body's overall ability to get nutrients where they need to go. If you've ever been told your genes are the problem, this episode will give you a much fuller picture. If you're ready to address the root drivers of your migraines, you can book a free consultation at the link below: https://www.drlesliecisar.com/apply Free Training: 5 Proven Steps to Being Migraine Free (Even if you think you've already tried everything.) https://www.drlesliecisar.com/5SHMN Connect with us: Website: https://www.drlesliecisar.com/ Free Facebook Group: Healing Migraines Naturally, with Leslie Cisar, ND Ready to try something radically different that actually works? Read more about my approach here: https://www.drlesliecisar.com/map In health,Dr. Leslie Cisar

In this “Connect The Dots” episode, Chris & Filly dive into a listener's case - where we unpack a flareup of menopausal symptoms, brain fog, poor concentration and focus post the COVID vaccine, and how this may have activated a fast COMT and MTHFR gene mutation. Chris & Filly cover: The presenting symptoms, when it all started & what she's tried so far The important of asking specific and deeper questions, to get the full picture “Life” - as a loaded statement Stages of menopause, and body systems that lead to menopausal issues and brain fog What MTHFR and COMT gene mutations actually are, and how they impact menopause Looking at menopause and a fast COMT gene through the lens of feminine and masculine energies The “not enough” loop Show Note Links: If you're keen to get your case workshopped (anonymously - you won't personally be on the episode) for free, fill in this application form. Book in for a Connect The Dots Initial Consult Join the Ending Body Burnout Method waitlist Take the Ending Body Burnout Assessment here Ep74 - Why Genetic Testing Can Do More Harm Than Good Disclaimer: This Ending Body Burnout Show podcast and any information, advice, opinions or statements within it do not constitute medical, health care or other professional advice, and are provided for general information purposes only. All care is taken in the preparation of the information in this Podcast. Chris & Filly Functional Medicine does not make any representations or give any warranties about its accuracy, reliability, completeness or suitability for any particular purpose. This Podcast and any information, advice, opinions or statements within it are not to be used as a substitute for professional medical, psychology, psychiatric or other mental health care or natural medicine health care. Chris & Filly Functional Medicine recommends you seek the advice of your doctor or other qualified health providers with any questions you may have regarding a medical condition. Inform your doctor of any changes you may make to your lifestyle and discuss these with your doctor. Do not disregard medical advice or delay visiting a medical professional because of something you hear in this Podcast. To the extent permissible by law Chris & Filly Functional Medicine and the Ending Body Burnout Show Podcast will not be liable for any expenses, losses, damages (including indirect or consequential damages) or costs which might be incurred as a result of the information being inaccurate or incomplete in any way and for any reason. No part of this Podcast can be reproduced, redistributed, published, copied or duplicated in any form without the prior permission of Chris & Filly Functional Medicine.

308: In this episode, Hector joins me for another Ask Me Anything where we catch up on everything that's been happening behind the scenes and answer your most-asked health questions. We share an update on navigating mold exposure during pregnancy, discuss what I'm currently doing to support detoxification, and discuss topics like glyphosate, MTHFR, folic acid vs. folate, peptides, and methylated vitamins. We also talk about alternative health insurance, homeschooling, wellness trends we're watching, and how we're making decisions to support our family's health. I hope this episode gives you a better understanding of some of the topics we've been learning about lately and encourages you to keep asking questions about your own health. Topics Discussed: → Mold Exposure During Pregnancy → Glyphosate Detox & Environmental Toxins → Folic Acid vs. Folate & MTHFR → Methylated Vitamins Explained → Peptides & Functional Medicine → Alternative Health Insurance Sponsored By: → Clearstem | Discover the CLEARSTEM difference — Because CLEAR SKIN CHANGES EVERYTHING. Go to https://clearstem.com/realfoodology and use code REALFOODOLOGY at checkout for 15% off your first order. → PaleoValley | Head to https://paleovalley.com/realfoodology for 15% off your first purchase. → Manukora | Head to https://manukora.com/REALFOODOLOGY to save up to 31% plus $25 worth of free gifts with the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook! → Timeline | Timeline's clinically proven formula is now more accessible. Mitopure starts at $99, and listeners can get 20% off at: https://timeline.com/REALFOODOLOGY → Cowboy Colostrum | Get 25% Off Cowboy Colostrum with code REALFOODOLOGY at https://cowboycolostrum.com/realfoodology → Shopify | Start your business today with the industry's best business partner, Shopify, and start hearing “cha ching.” Sign up for your one-dollar-per-month trial today at https://shopify.com/realfoodology → 00:00:00 - Why Our Food System Is Failing Us → 00:00:54 - Welcome + Ask Me Anything Begins → 00:01:50 - Pregnancy & Mold Exposure Update → 00:04:40 - California's Folic Acid Mandate Explained → 00:08:49 - Folic Acid vs. Folate & MTHFR → 00:13:09 - How I Detox from Glyphosate → 00:21:28 - Wellness Trends I'm Watching → 00:26:26 - Peptides & the Future of Functional Medicine → 00:29:00 - Why We Switched to CrowdHealth → 00:32:37 - Will We Homeschool Our Kids? → 00:35:55 - Methylated Vitamins Explained → 00:40:47 - Why I Stopped Asking Guests Their Health Non-Negotiables Further Listening:  → The Truth About Folic Acid: MTHFR, Prenatals & What to Take Instead | Dr. Ben Lynch → How to Opt Out of Big Insurance - And Still Get Covered | Andy Schoonover → The Secret to Healthier Kids: Clean Air and Better Schools! | Mike Feldstein of Jaspr→  LEAVE US A VOICE MESSAGE →  Check Out My new FREE Grocery Guide! →  @realfoodology →  www.realfoodology.com →  My Immune Supplement by 2x4 →  Air Dr Air Purifier →  AquaTru Water Filter →  EWG Tap Water Database Produced By: Drake Peterson Learn more about your ad choices. Visit megaphone.fm/adchoices

Send me a text! I'd LOVE to hear your feedback on this episode!You've been sold the three-day cleanse, the celery juice, the tea with a coupon code. And you've probably also heard a doctor say detox is nonsense because your body already does it on its own. Both are missing the same thing: drainage.In this episode I break down — in plain language — what detoxification actually is, what drainage is, and why one has to come before the other. I walk you through the machinery: the liver, the kidneys, the bowel, the skin, the lungs, and the lymph — the system with no pump, which moves only when you do.Then I get into what changes in midlife. Liver capacity drops. Glutathione declines. Kidney filtration slows decade by decade. Motility slows, and low estrogen and low thyroid make it worse. Estrogen influences how your gallbladder empties and how thick your bile gets, which is why gallbladder issues climb for women at exactly this stage. Menopause isn't only hot flashes and broken sleep. It's a drainage story.I also cover:- Liver phase one and phase two — and the reason phase one can make you feel worse before phase two catches up- The emunctories — your organs of elimination — and the order you have to open them- Biotherapeutic drainage and UNDA: the early-1900s European lineage behind Nebel, Discry and Reuter, and how a plant tincture paired with a homeopathic metal actually targets a specific organ- MTHFR, methylation as a phase two pathway, and my own genetics — held without the internet's drama- Where drainage costs nothing, and the free daily practices I'd start with- My own experience with cysts under the arm, and how I read it- Why emotional stagnation is a terrain too, and what it means to drain the soulNothing here is medical advice. I'm giving you breadcrumbs — take them to a qualified practitioner, one trained specifically in drainage.If this one lands, share it with one person and hit follow. It genuinely helps the show get found.Support the showInstagram:  https://www.instagram.com/sandyknutrition/Facebook Page:  https://www.facebook.com/sandyknutritionTikTok:  https://www.tiktok.com/@sandyknutritionYouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAgRumble:  https://rumble.com/c/c-5461001Linkedin:  https://www.linkedin.com/in/sandyknutrition/Substack:  https://sandykruse.substack.com/Podcast Website:  https://sandykruse.ca

Olympic medalist turned health-tech founder Andrew Steele says the problem isn't you: it's that "normal" and "optimal" are two different things. In this episode, he breaks down how DNA, microbiome, and blood testing expose what's really behind your fatigue, brain fog, and bloating. And why one test, one time, will never tell you the full story. WHAT YOU'LL LEARN -       Why small, consistent daily habits move the needle on longevity more than big lifestyle overhauls -       How the ACTN3 gene explains why "average" training and health advice doesn't work for everyone -       What DNA methylation is, and why taking more B vitamins can backfire if you have an MTHFR variant -       Why "normal" bloodwork isn't the same as optimal health -       How the PhenoAge biological age test measures how fast you're really aging -       Why bloating and brain fog in midlife women are often linked to the estrobolome and gut bacteria -       Why microbiome and blood testing needs to be repeated over time, not done once -       The best way to prepare for accurate blood and microbiome test results -       The three biomarkers Andrew recommends testing first: methylation, gut-brain axis, and ApoB -       Why wearables alone can't give you the full picture of your health -       How Stride is integrating oral microbiome testing and wearable data -       Why data and dashboards alone don't change behavior without human coaching -       What's inside Stride's ST01 liposomal multivitamin and why it's formulated around methylation   TIMESTAMPS 00:00 Small Daily Habits, Genetics And The ACTN3 Gene Story 09:35 DNA Methylation, MTHFR And Why More B Vitamins Isn't Always The Fix 13:15 Why "Normal" Bloodwork Isn't Optimal, And The Biological Age Test 20:45 The Gut-Hormone Link In Midlife Women, And Why You Need To Retest 31:00 How To Get Accurate Results, And The 3 Biomarkers Worth Testing 36:45 The Future Of Health Tracking: Wearables, Oral Microbiome And Multiomics 40:30 Stride Membership Availability And Discount Code 43:45 Why Data Alone Won't Change Your Health Without Human Coaching 46:30 Inside Stride's ST01 Supplement, And Final Thoughts On Aging Well VALUABLE RESOURCES A BIG thank you to our sponsor who make the show possible: • Stride - Find out your biological age and how your daily habits are influencing it with DNA, bloodwork and microbiome testing with a Stride One membership  https://www.getstride.com/angela/ for 10% off  -       Follow Andrew on Instagram: https://www.instagram.com/andrewsteele/  ABOUT THE GUEST   Andrew Steele is a former Olympic medalist sprinter turned genomics entrepreneur. He co-founded DNAFit in 2013 and has spent over a decade building consumer genomics, microbiome, and blood-testing products. He is now the founder of Stride, a multi-omic health platform combining DNA, microbiome, and blood testing with in-house practitioner consultations to help people move from "normal" to optimal health. Want to go deeper? Start here:

MTHFR isn't just about detox—it's a critical player in your mental well-being. Discover why this genetic variation is more closely linked to mood, energy, and neurological health than you think, and how to optimize your health even with an MTHFR SNP. TIMESTAMPS 00:00 Intro: MTHFR Confusion 02:15 MTHFR: Not a Detox Doom Sentence 04:05 The Mental Health Connection 06:30 MTHFR's Impact on Neurotransmitters 08:45 B Vitamins, Folate, and Energy 11:10 MTHFR and Melatonin Production 13:20 Liver Detox Pathways Beyond MTHFR 15:45 Why Mental Health Is Key 18:00 The SSRI Connection to B Vitamins 20:15 Optimizing MTHFR Through Lifestyle 22:30 Personalized Approaches to MTHFR 25:00 Final Thoughts & Hope LINKS

Can you prevent preeclampsia? In this deep dive, we look at the root causes, proposed mechanisms, and holistic support strategies for one of the most serious complications of pregnancy. We are learning more about what may contribute to preeclampsia, including placental development, inflammation, oxidative stress, mitochondrial dysfunction, endothelial health, genetics, nutrient status, paternal factors, the microbiome, environmental toxins, and long-term cardiovascular risk.Aspirin is one of the most recommended prevention tools, and in this episode we get into why it is used, what it actually does, and where its benefits seem strongest. But it turns out, there may be a lot more to the prevention conversation.In this episode, we cover:What preeclampsia is and how it is diagnosedThe two-stage model of preeclampsia: abnormal placental development and maternal vascular dysfunctionOxidative stress, inflammation, mitochondrial dysfunction, platelet activation, and endothelial healthGenetic factors: MTHFR, homocysteine, methylation issuesEpigenetics: how lifestyle may influence gene expression in pregnancyEnvironmental toxins, including BPA, phthalates, PFAS, heavy metals, air pollution, and placental healthThe paternal factor: semen exposure, paternal antigens, sperm health, obesity, and immune toleranceGut, vaginal, oral, and urinary microbiome researchCOVID infection, COVID vaccination data, and preeclampsia riskWhy preeclampsia is linked to future cardiovascular diseaseWhat the evidence actually says about baby aspirinSupplements that may help with prevention: Calcium, vitamin D, magnesium, lycopene, omega-3s, CoQ10, NAC, and moreNutrition: the DASH diet, Mediterranean diet, fiber, probiotics, and food-first nutrition strategiesExercise in pregnancy and what we know about hypertensive disordersSleep, obstructive sleep apnea, and preeclampsia riskMind-body medicine, stress physiology, mindfulness, yoga, acupuncture, and blood pressure regulationHow to think about prevention without fear, blame, or over-supplementingThe full episode transcript with citations for all studies mentioned can be found at: drmaryellawood.com

Dr. Tyler Panzner joins Dr. Mike Hart to explain how genetics, supplement combinations, and individual brain chemistry can influence anxiety, irritability, brain fog, and the persistent "monkey on your back" feeling. They examine why the MTHFR gene is scientifically valid but often overmarketed, and why methylated B vitamins, SAMe, creatine, phosphatidylcholine, and other methylation-related supplements may help some people while overstimulating others. The conversation also explores hidden "adrenaline trappers" such as quercetin, polyphenols, and greens powders; why NAC, glutathione, and high-dose antioxidants may cause unwanted effects; and how lithium orotate, melatonin, nicotine, methylene blue, omega-3s, collagen, mitochondrial enhancers, and DHT-lowering supplements can affect people differently. Dr. Panzner also discusses pharmacogenomics, SSRI response, supplement timing around exercise, the limitations of genetic testing, and the importance of combining DNA data with bloodwork, symptoms, medication history, and baseline nutrient status. Dr. Tyler Panzner is a pharmacology and genetics expert whose work focuses on personalized supplementation, genetic testing, neurotransmitter pathways, and understanding why the same health intervention can affect people very differently. Through DNA analysis, laboratory review, supplement audits, and individualized coaching, he helps clients identify which biological pathways may need support and which commonly recommended supplements may be working against them. His approach challenges one-size-fits-all biohacking and emphasizes using genetics, bloodwork, symptoms, and personal response patterns to make more informed decisions about mental health, performance, and long-term wellness.   Work with Dr. Tyler Panzner! Unlock Your Genetic Potential — Dr. Tyler Panzner https://drtylerpanzner.com/ Dr. Tyler Panzner on Instagram — Tyler Panzner https://www.instagram.com/drtylerpanzner/ Quieting an Overactive Mind Webinar — Tyler Panzner https://overstimulated.drtylerpanzner.com/webinar-registration-page   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:47 MTHFR Hype vs Reality 02:14 Methylated Bs and Anxiety 03:48 Creatine Choline and SAMe 07:43 Beyond One Gene Test 11:14 Lithium Orotate Basics 15:18 Supplements That Backfire 17:36 Antioxidant Overload Effects 21:01 Melatonin Dose Debate 23:56 Antioxidants Around Workouts 26:48 Collagen What Actually Works 30:07 SSRIs and Genetic Fit 34:23 Herbal SSRI Alternatives 37:18 DHT Lowering Side Effects 41:54 Biohacking Marketing Hype 43:25 Fish Oil Mood Ratios 46:16 Oral Nicotine Tradeoffs 52:03 Methylene Blue Risks 54:46 Mitochondria Boosters Anxiety 57:13 Greens Powders Overstimulation 01:01:04 Magnesium Forms For Sleep 01:04:51 DNA Testing And ChatGPT 01:12:23 Genetics For Caffeine Sensitivity 01:16:23 Psychedelics And DNA 01:18:50 Coaching Logistics Wrap Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

☎️ Book Your COMPLEMENTARY CONSULTATION and CALORIE CALCULATION Call: https://calendly.com/d/2p8-mxx-dgf/free-consultation-call-zoom⁠⁠⁠⁠⁠⁠

Estrogen dominance is the hidden imbalance behind why your PMS, weight gain, and mood swings all hit at the same time — and most doctors never test for it. Nurse Doza breaks down four clinical reasons your cycle goes sideways: inflammation, dysregulated estrogen, your gut microbiome (the estrobolome), and an inflamed liver. Learn how your gut and liver actually regulate estrogen, why birth control isn't the fix, and the daily habits that restore a healthier, calmer cycle. Featured Product: Boost by MSW Nutrition When your hormones go sideways before your period, energy is usually the first thing to crash — the afternoon wall, the brain fog, the "I could nap standing up" fatigue Nurse Doza describes in this episode. Boost is the multivitamin you can actually feel: 2,500 mcg of methylated B12, a full multivitamin plus B-complex, electrolytes, and plant-based antioxidants including S-acetyl-L-glutathione — with a built-in liver detox support blend to help your body do the clearing work we talked about today. Clean, slow-release energy from one stick in water. No sugar, no crash.

In this episode of The Birth Lounge Podcast, HeHe continues her series on one of the most requested and emotionally charged topics in parenting: vaccines. She's joined by pediatrician and The Vaccine Book author, Dr. Bob Sears, for a thoughtful conversation about vaccine schedules, informed consent, and why so many parents feel caught between asking questions and feeling heard. Together, they explore how vaccine recommendations have evolved over time, what influences the current childhood vaccine schedule, and why trust between families and the medical system has become increasingly strained. Throughout the conversation, Dr. Sears shares his perspective on topics including timing of vaccination, measles and the MMR vaccine, herd immunity, newborn protection strategies, breastfeeding antibodies, and questions many parents have about vaccine ingredients, package inserts, MTHFR, and vaccine safety research. He also discusses why some families seek individualized approaches to vaccination and what he believes parents should consider when making decisions with their healthcare provider. As with every episode in this series, this conversation is not intended to tell you what decisions to make for your family. Instead, HeHe's goal is to create space for respectful discussion, equip parents with information, and encourage thoughtful conversations with trusted healthcare providers so you can make informed decisions that align with your family's values. Whether you're firmly decided, still gathering information, or simply curious about the questions many parents are asking, this episode invites you into a conversation centered on nuance, critical thinking, and respectful dialogue. 00:00 Vaccine Indoctrination Claim 01:08 Advocacy Scripts for Birth 04:22 Vaccine Series and Guest Intro 11:42 Why Trust Broke Down 39:24 Vaccines and Immune System Theory 49:35 Why MMR Hits Hard 52:18 Measles Risk and Nutrition 56:42 Vaccine Side Effects Data Gap 01:01:13 Herd Immunity Myth 01:04:31 Newborn Cocooning and Shedding 01:11:35 Pregnancy Vaccine Repeat Doses 01:14:43 MTHFR and Vaccine Decisions 01:20:18 Will Diseases Return 01:23:43 Finding Like Minded Care 01:26:35 Resources and Farewell Guest Bio: Dr. Bob Sears is a pediatrician, vaccine educator, and author of The Vaccine Book. He earned his medical degree at Georgetown University School of Medicine and did his pediatric internship and residency at Children's Hospital Los Angeles. With the ongoing threat of mandatory vaccination laws, Dr. Bob's mission is to insure that all families worldwide receive complete, objective, and un-doctored informed consent before they choose vaccination and that people everywhere retain the freedom to make healthcare decisions for themselves and their children.   https://drbobsears.com/ SOCIAL MEDIA: Connect with HeHe on Instagram: https://www.instagram.com/tranquilitybyhehe/ Connect with Dr. Sears on IG: https://www.instagram.com/drbobsears BIRTH EDUCATION: Learn how to stay in control of your birth and reduce the risk of unnecessary interventions in our Avoid a C-Section Webinar. HeHe breaks down the cascade of interventions, explains what's really happening in the hospital, and shares practical strategies to protect your birth plan, advocate for yourself, and navigate labor with confidence. Perfect for anyone who wants a positive, informed hospital birth experience: https://www.thebirthlounge.com/csection Feeling nervous about speaking up in labor? Our Scripts for Advocacy give you the exact words to handle the most common conversations that can make or break your birth experience. From declining unnecessary interventions to asking the right questions about procedures, these scripts empower you to stay in control, speak confidently, and protect your birth plan — even when the pressure is on. Think of it as your personal toolkit for advocating like a pro, so you can focus on your baby, not the stress: https://www.thebirthlounge.com/Scripts-for-Advocacy And if you haven't grabbed it yet… Snag my free Pitocin Guide to understand the risks, benefits, and red flags your provider may not be telling you about, so you can make informed, powerful decisions in labor: https://www.thebirthlounge.com/pitocin   Want prep delivered straight to your phone? Download The Birth Lounge App for bite-sized birth and postpartum tools you can use anytime, anywhere: https://www.thebirthlounge.com/app   LINKS MENTIONED: https://www.vaclib.org/basic/health/patientchoicedoctors.htm Just the Inserts website: find vaccine inserts on this website and vaccine friendly Pediatricians  Dr. Green mom's list of vaccine friendly Pediatricians: https://drgreenmom.com/find-a-vaccine-friendly-doctor/  

What if the disease you were told to “manage forever” wasn't your body failing you — but your cells starving, poisoned, and running out of energy? In this episode, Dr. Josh Axe reveals why your body replaces 330 billion cells every day, and why the real root of fatigue, inflammation, hormone problems, autoimmune disease, and accelerated aging may begin far deeper than your organs: at the cellular level. Uncover what's really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

Could Mitochondrial Health and Cellular Aging and your unique genetic blueprint be the missing link behind your energy, inflammation, and long-term wellness?     In this fascinating episode of the Lisa Fischer Said Podcast, Lisa sits down with Dr. Sam Shay, chiropractor, genetic health expert, comedian, and creator of the NeuroSpicy comedy special. Dr. Shay explains how genetics influence everything from carb tolerance and caffeine sensitivity to exercise recovery, inflammation, methylation, and overall health outcomes.     They unpack the truth about MTHFR, why genetics are far more complex than a single gene mutation, and how personalized nutrition can outperform one-size-fits-all wellness advice. Dr. Shay also shares his personal experience with Asperger's syndrome, discusses AI's growing influence on healthcare, and explains why understanding your DNA can help you make smarter lifestyle decisions.     If you've ever wondered whether your body is wired differently than everyone else's, this episode offers practical insights into personalized health optimization.    

This week we're throwing back to a powerful conversation between Ivelisse and Megan Van Zyl, founder and CEO of Cancer Peace University. Megan dives into healing cancer from every angle, physical, emotional, and spiritual, starting with her favorite health tip: connecting lifestyle change to a deeper sense of purpose. She unpacks immune "anergy," chronic infections like H. pylori and hepatitis, toxins, parasites, and the often-overlooked links between thyroid health, mitochondrial function, and oxygen deficiency in cancer. Megan also walks through detox roadblocks like slow methylation, MTHFR issues, lymph stagnation, and liver backup, sharing practical tools like dry brushing, rebounding, coffee enemas, and infrared saunas, plus the role of modified citrus pectin in reducing cancer cell "clumping" around biopsy or surgery.But the conversation goes beyond the physical. Megan explores psycho-neuroimmunology and how childhood trauma can quietly suppress the immune system's natural killer cells, why talk therapy sometimes isn't enough, and offers gentle tools like free-association journaling and trauma timelines for deeper healing. Faith, hope, and stories of spontaneous remission are woven throughout, reflecting the heart of Cancer Peace University's mission. It's an episode full of insight, encouragement, and real hope for anyone walking through a cancer journey.Learn more about Megan Van Zyl and Cancer Peace University:https://cancerpeaceuniversity.com/the-bridge-program/ Suggested Resource Links:Cancer Peace UniversityBOOK:  Patient, Heal Thyself by Jordan RubinThe Warburg EffectBOOK:  Change Your Cancer Story: Why Some Heal & Others Don't by Megan Van ZylBOOK:  Braving the Storm: Find Hope During a Cancer Diagnosis by Megan Van ZylBOOK:  Fuel Your Body, Not Your Cancer - Anti Cancer Cookbook by Megan Van ZylYour donations power our podcast's mission to support cancer patients with hope, insights, and resources. Every contribution fuels our ability to uplift and empower. Join us in making a lasting impact. Donate now!

Tired of choking down pills and wondering if any of it is showing up? Transdermal could be the answer. The Patch Method bypasses our digestion and liver completely. Super easy, just slap it on. Code NATALIEJILL for 20% off at http://thepatchmethod.com  PLUS… DM "NatalieJill" to @the.patchmethod on Instagram and the first 50 people will receive a free patch kit of their choice plus four free samples. What if the drawer full of supplements you have been faithfully taking every morning is actually making your liver work harder without making you feel any better? If you have ever walked out of a functional medicine or naturopathic appointment with a list of twelve supplements, spent hundreds of dollars filling that order, and then showed up to your next appointment still deficient in the very things you were supplementing, you are not alone. And according to Lindsey Burwell, founder of The Patch Method, you are also not the problem. Lindsey was one of my most talked-about guests ever, and she is back for part two because your questions did not stop after our first conversation. Today we go even deeper into why swallowing supplements is often a losing game for midlife women, and what transdermal delivery actually does differently at a physiological level. We cover the science of first-pass metabolism and why your liver, already under enormous strain from modern life, is simply not prioritizing breaking down your vitamin C. We talk about what "pill fatigue" really is and why it is only getting louder. And we get into the specific patches Lindsey has developed, including the detox patch, the cortisol fix, the menopause patch, and the one I have been waiting to try: the GHKCU copper peptide glow patch, which has serious research behind it for skin regeneration, hair growth, and cellular repair. I also finally get Lindsey to walk me through why the injectable version of that copper peptide causes that intense, all-day throbbing sensation, and why the transdermal version sidesteps that entirely. Spoiler: it comes back to dose. If you have MTHFR or a slow COMT and have had bad reactions to methylated B vitamins, Lindsey explains exactly why the patch form does not cause that same stimulant response. We also dig into who should and should not be using these patches, how to stack them, and why you do not have to give up the supplements that are already working for you. This is one of those episodes that makes you want to go audit your entire supplement cabinet.   WE GO DEEP ON:  Why your liver may be working 3,000x harder than it used to Why supplements are dosed at 10,000% of your daily need What actually happens to a pill before it reaches your bloodstream Why MTHFR carriers react badly to B vitamins in pill form, not patches The detox patch protocol for clearing excess estrogen on HRT Why the GHKCU injectable causes all-day throbbing, and the patch doesn't What 90 days of copper peptide use can do for hair and skin The adaptogen blend behind some of the best sleep scores Lindsey has seen Whether you can stack multiple patches at once Who should never use these patches   Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube   Learn More About Lindsey Burwell Instagram ➜ http://www.instagram.com/the.patchmethod  Website ➜ http://thepatchmethod.com use code NATALIEJILL to save    Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com   Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit   For advertising inquiries: https://www.category3.ca/  Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen.  Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.  

305: Welcome back to another AMA! Hector joins me again as we answer your questions on pregnancy, birth prep, wellness trends, and more. I share a candid update on how I've been navigating pregnancy, grief, and mold recovery, plus what's making it onto my birth playlist (yes, it includes everything from Lane 8 to screamo). We also dive into my predictions for wellness in 2026, the growing obsession with adding protein to everything, and the books, documentaries, and resources that have shaped my perspective on childhood vaccines and informed parenting decisions. Sponsored By: → Timeline | Timeline's clinically proven formula is now more accessible. Mitopure starts at $99, and listeners can get 20% off at: https://timeline.com/REALFOODOLOGY → Manukora | Head to https://manukora.com/REALFOODOLOGY to save up to 31% plus $25 worth of free gifts with the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook! → Ogee | Thanks to today's sponsor, Ogee: A higher standard for beauty. Go to https://ogee.com/REALFOODOLOGY and use code REALFOODOLOGY to get 20% off certified organic makeup that performs like luxury. → Cowboy Colostrum | Get 25% Off Cowboy Colostrum with code REALFOODOLOGY at https://cowboycolostrum.com/realfoodology → PaleoValley | Head to https://paleovalley.com/realfoodology for 15% off your first purchase. Timestamps:  → 00:00:00 - Introduction → 00:00:05 - Mold Exposure, Pregnancy + Grief Update → 00:00:24 - Wellness Predictions for 2026 → 00:01:20 - What's on My Birth Playlist? → 00:03:04 - Labor Music, Hypnobirthing + Pregnancy Prep → 00:06:55 - Vaccine Resources for Parents → 00:08:31 - Why We're Keeping Our Decision Private → 00:09:00 - Finding a Pediatrician That Aligns With Your Values → 00:10:11 - Vaccine Mandates, Incentives + Medical Freedom → 00:13:00 - What Changes Could Mean for Parents → 00:19:49 - Blood Work, Full-Body Scans + Preventative Testing → 00:21:22 - MTHFR, Glyphosate + Advanced Health Markers → 00:22:00 - Do You Need a Functional Medicine Doctor? → 00:23:40 - Final Thoughts Show Links: → realfoodology.com Check Out Courtney:  →  LEAVE US A VOICE MESSAGE →  Check Out My new FREE Grocery Guide! →  @realfoodology →  www.realfoodology.com →  My Immune Supplement by 2x4 →  Air Dr Air Purifier →  AquaTru Water Filter →  EWG Tap Water Database Produced By: Drake Peterson Learn more about your ad choices. Visit megaphone.fm/adchoices

What if the supplements you've been taking to feel better are actually the reason you feel worse? That's exactly what happened to me, and it sent me down a rabbit hole that led to one of the most important conversations I've had about my own health. Today I'm sitting down with my close friend and personal doctor, Dr. Sabrina Solt, a regenerative medicine physician and peptide expert who has been in this field for over a decade. We start with the question that started everything for me: why was I wired at 3am, crashing every afternoon, and reacting to the exact supplements I thought were helping? Dr. Solt breaks down the cortisol-prolactin connection that most doctors never test for, explains why elevated cholesterol in midlife women is often a protective response rather than a red flag, and walks us through the inflammation markers that actually tell the full story of what's happening inside the body. Then we go deep on what she calls the upstream-downstream problem, the real reason why things like methylated B vitamins, NAD drips, and glutathione pushes can backfire so badly in certain women, and what to do instead. She explains the genetic piece around MTHFR and COMT variations, why "more" is rarely the answer, and what supporting downstream clearance actually looks like in practice. From there, we get into peptides. Dr. Solt gives a grounded, clinical breakdown of BPC-157, TB-500, KPV, the copper peptide GHKCU, growth hormone releasing peptides, and the serious cautions around GLP microdosing gone wrong. She also shares her vision for what medicine could look like if doctors were equally fluent in peptides and pharmaceuticals. This is the conversation I've been wanting to bring to you for a long time. Dr. Sabrina Solt is one of the most precise and brilliant minds I know, and she does not hold back.   WE GO DEEP ON:  The cortisol-prolactin connection most doctors never test Why high cholesterol isn't always the villain (and what MPO reveals) The upstream-downstream mistake making "healthy" habits backfire Why NAD and glutathione drips can be dangerous for some people A no-BS peptide breakdown: BPC-157, TB-500, KPV, copper peptides, and more The truth about GLP microdosing and its risks What to fix before you ever try a peptide   Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube   Learn More About Sabrina Solt  Instagram ➜ http://www.instagram.com/drsolt  Website ➜ http://www.stemcelltherapypro.com/  Peptide Membership Website ➜  https://dr-solts-peptide-corner.circle.so/forms/dfdcc2cd        Thank you to our show sponsors:  QUANTUM UPGRADE: Try Quantum Upgrade completely free for 15 days—no credit card required. Use code NATALIEJILL at checkout on https://quantumupgrade.io/start  TIMELINE: Timeline is offering 20% off your order of Mitopure! Go to https://timeline.com/NATALIEJILL  Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com   Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit   For advertising inquiries: https://www.category3.ca/  Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen.  Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.  

Nitric Oxide Explained: Vascular Health, Exercise Performance, and N1o1 with Dr. Nathan Bryan, international Leader in Molecular Medicine, the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He details NO as a ubiquitous messenger affecting blood flow, erectile function, cognition, exercise performance, endothelial dysfunction, and aging-related declines in NO production. Bryan explains why PDE5 inhibitors like Viagra prolong cyclic GMP signaling but don't fix NO deficiency, and why beet products often fail due to variable nitrate content and inadequate dosing. He outlines his NO lozenge approach that generates NO gas from sodium nitrite and magnesium ascorbate, plus a fermented beet powder drink (NOBeets), and emphasizes the role of oral bacteria (and harms of antiseptic mouthwash/fluoride) in nitrate conversion. They review published endpoints, including flow-mediated dilation, blood pressure effects, inflammation markers, triglycerides, stem cells, plaque regression, applications to Alzheimer's, glaucoma/microvascular disease, safety/dosing considerations, risks of arginine supplementation, and a dual-chamber topical NO serum developed from wound-healing experience.

What if the secret to overcoming chronic fatigue, brain fog, and cellular aging lies within your mitochondria? In this episode of The Better Life, host Dr. Mary Ann Pinkston sits down with international speaker, researcher, and cellular medicine expert Dr. Gordon Crozier from the Crozier Clinic. Together, they dive deep beneath the surface of traditional medicine to explore how integrative, evidence-based approaches can truly revitalize your health. If you’ve been slamming methylated B vitamins for MTHFR mutations but still feel completely exhausted, this conversation is the missing piece of your puzzle. What You’ll Learn in This Episode: The Truth About NAD+: Why this vital cellular coenzyme is essential for DNA repair, intense detoxification, and mitochondrial energy. NAD+ vs. Precursors: The difference between raw IV NAD+ (and why it causes nausea) versus cutting-edge precursors like NMN and True Niagen. The Magic of Methylene Blue: How this powerful antiviral compound works in concert with NAD+ to supercharge the electron transport chain—and why you must take structured breaks from it. Deep-Dive Methylation: Why methylation goes far beyond MTHFR, impacting hormone breakdown, breast and prostate cancer prevention, and neurodegenerative risks. Natural NAD+ Boosters: How everyday habits like proper weight management, targeted protein intake, and consistent exercise naturally elevate your levels. The Danger of "Supplement Overload": Why less is often more, and the hidden risks of buying non-third-party tested supplements off the shelf. Important Safety Note: Dr. Crozier explains why compounding quality matters and highlights critical contraindications for Methylene Blue, including SSRIs (Serotonin Syndrome risk) and G6PD deficiencies. Connect with the Experts: Find Dr. Gordon Crozier: Learn more about his practice, research, and social media at CrozierClinic.com. Find Dr. Mary Ann Pinkston: Access past episodes, resources, and links discussed in today's show at drpbetterlife.com. See omnystudio.com/listener for privacy information.

In this deeply informative and compassionate episode of Our Forever Smiles, host Laura Bethea sits down with longtime genetic counselor Robin Imagire to unpack one of the biggest questions cleft families ask: Why did this happen? With over 30 years of experience working alongside craniofacial teams, Robin shares honest insight into the complex world of cleft genetics, including what "multifactorial" really means, why most clefts don't have a clear-cut answer, and how environmental and genetic factors may work together. Laura also opens up about her daughter Giselle's cleft palate journey, her family's experience with genetic testing, and the emotional weight many parents carry while searching for answers. Together, they discuss: Why NIPT testing often doesn't detect clefts Common syndromes associated with cleft lip and palate Pierre Robin Sequence, Van der Woude syndrome, and 22q deletion The truth about the MTHFR gene and cleft rumors online Whether clefts can be prevented The emotional side of receiving a diagnosis as a parent This episode is filled with reassurance, practical education, and the reminder every cleft parent needs to hear: you are not alone, and this is not your fault. Whether you're newly diagnosed, navigating surgeries, or simply trying to better understand your child's cleft journey, this conversation offers clarity, comfort, and hope. Links: Buy Us a Coffee FB Support Group

Send Vanessa a Text MessageA special listener discount is available for Mara Labs products featured in this episode: Explore Mara Labs (Code is VANESSA)If you enjoy the podcast and want to support Vanessa's work, you can do so here: Buy Me a Coffee – Intentionally WellIn this episode, I'm joined by David Roberts, founder of Mara Labs, for a conversation exploring cellular health, modern environmental stressors, and the body's natural resilience systems.David's journey into this space began after his late wife Mara's cancer diagnosis, which led him to deeply explore plant-based compounds and how they interact with cellular protection and repair mechanisms. That path eventually led to the development of BrocElite, a stabilized sulforaphane supplement designed to support detoxification pathways, mitochondrial function, and overall cellular resilience.We discuss topics including sulforaphane, oxidative stress, detoxification and autophagy pathways, metabolic health and GLP-1 signaling, genetic variability such as MTHFR and COMT, and how modern environmental exposures like microplastics may be impacting overall health.This is a wide-ranging conversation aimed at helping make complex biology more understandable and grounded in real-life application.Key Topics Covered: Sulforaphane and cellular defense systems  Detoxification pathways and autophagy  Mitochondrial health and oxidative stress  Modern environmental exposures (including microplastics)  Metabolic health and GLP-1 signaling  Genetic variability (MTHFR / COMT) and sensitivity  Why some people feel more reactive in today's environment Sulforaphane and pet health BrocElite and Mara Labs story Connect with David:Mara Labs on InstagramExplore Mara LabsConnect with Vanessa and the podcast: IWP Website: Intentionally Well PodcastIWP Recommended ProductsPodcast on InstagramVanessa on InstagramPodcast on YouTubeVanessa on TikTokVanessa on XEmail: intentionallywellpodcast@gmail.comSupport the showThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Dr. Stacey Clardy discusses methylenetetrahydrofolate reductase (MTHFR) in this lab minute.   Show transcript:  Dr. Stacey Clardy: Hi, this is Stacey Clardy from the Salt Lake City VA in the University of Utah. Let's do a lab minute today on MTHFR. This one just simply will not go away. This is one of those topics where a huge amount of patient anxiety is inversely proportional to the utility of a test. So MTHFR is methylenetetrahydrofolate reductase. It's the enzyme that helps generate five methyltetrahydrofolates supporting remethylation of homocysteine to methionine. That biochemistry does matter because the clinical leap that often follows is the problem. So the common polymorphisms of MTHFR are C677T and A1298C. They are widespread in the general population. A recurring misunderstanding is that ordering MTHFR genotyping in a thrombophilia evaluation or as a catchall explanation for you name it, migraines, neuropathy, psychiatric symptoms, nondescript inflammation, is going to give you the answer. The best evidence-based guidance is that MTHFR polymorphism testing has minimal clinical utility and should not be ordered routinely, particularly not as part of a thrombophilia evaluation.So what do we do when a patient arrives with one of these MTHFR results and they are concerned? I try to translate into what actually matters clinically. If there is a concern for thrombotic risk or a documented thrombotic risk event, I focus on established thrombophilias and clinical risk factors and not common MTHFR isolated variants. Now, if the concern is folate metabolism and homocystine, well, we can actually measure those nutritional markers and homocystine. And so if homocystine is elevated, the next thing I'll do is consider the context. And if their folate is low or if one of their B vitamins is low, I replace it rather than building a medical mythology around a genotype that's not going to change the management for most patients. So that's an approach and an update to MTHFR. I hope it's helpful. This is Stacey Clardy, until next time. 

If you are thinking about having a baby in the next year or two, or you have been trying for a while and wondering if your nutrition could be doing more, this episode is a genuinely useful place to start. And if you are in your 20s or 30s and have not had a blood test recently because you feel fine and assume everything is probably okay, Leanne and Susie have something to say about that too. This week on The Nutrition Couch, they dig into the nutrition and lifestyle strategies that actually move the needle on fertility outcomes, what the research says about diet patterns, key nutrients, and male fertility, and the common mistakes that quietly work against conception that most women have never been told about. In this episode: The Australian longitudinal study of over 5,000 women linking anti-inflammatory dietary patterns to better fertility outcomes, and what that actually looks like on a plate day to day The key nutrients that appear time and time again in fertility research: omega-3s, vitamin D, vitamin E, and natural folate, why food sources beat supplements in almost every case, and the one supplement Susie did take during pregnancy The MTHFR gene mutation: what it is, how common it is, why women with this mutation should not be taking synthetic folate in standard prenatal supplements, and how to find out if you have it Why male fertility contributes to 40 to 50% of fertility challenges and is chronically overlooked, and what partners should actually be doing differently The under-eating and overtraining pattern that silently disrupts ovulation and hormonal health even in women who appear to be doing everything right The truth about caffeine and fertility: the research does not say what most people assume, and Susie explains exactly how much is genuinely safe if you are trying to conceive The blood tests Leanne recommends for every woman in her 20s and 30s, including the ones most GPs do not automatically order, and the vague symptoms that are easy to dismiss but might actually signal something easily fixed Why low ferritin is one of the most underdiagnosed and undertreated issues in young Australian women, and Susie's case study of a client whose iron had been dangerously low for two decades without anyone properly addressing it The Harvest Pantry Protein Smoothie reviewed: clean ingredients, impressive packaging, and a protein claim on the front of the pack that requires an asterisk the size of a footnote to actually be true The nine-month-old baby and solids question: how much milk is too much, why iron should be the focus of every meal at this age, and the feeding order that makes a bigger difference than most parents realise Shop Designed by Dietitians: Looking to support your protein, creatine, magnesium, or collagen intake with evidence-based supplements made in Australia? Visit designedbydietitians.com Keep sharing The Nutrition Couch with the women in your life. This is exactly the kind of episode worth passing on.See omnystudio.com/listener for privacy information.

In this episode of The Vibe With Ky Podcast, I sit down with Rhiannon Neuharth to talk about nervous system regulation, MTHFR, and getting out of survival mode.If you have piled on supplements, planners, and apps and still feel stuck, tired, and foggy, this episode is exactly for you.Learn more from Rhiannon and grab her free MTHFR 101 guide, her ADHD Brain Food mini course, and her comprehensive testing info here:https://www.revitalizing-wellness.comThis episode is sponsored by Sucreabeille. Check them out here:https://sucreabeille.com/products/why-did-i-walk-into-this-roomRhiannon is a former biology and physiology teacher turned health coach who helps burnt-out women understand their bodies using their genes as a blueprint. We get into why your nervous system is the foundation for focus, mood, and energy, and why nothing else holds when your body is stuck in fight or flight.What you will take away from this one:Why your body cannot absorb supplements or stick to routines while it is running in survival modeHow the MTHFR gene and gut health quietly shape brain fog, focus, and fatigueA simple way to build a morning routine through habit stacking without the overwhelmSupport the show and find more resources:Website and blog: https://thevibewithky.comMental Health Resources Hub: https://thevibewithky.com/mental-health-resources-hub/Instagram: instagram.com/thevibewithkyPatreon Subscriber Hub: https://www.patreon.com/thevibewithkyFacebook Subscriber Hub: https://www.facebook.com/thevibewithky/subscribe/Disclaimer: This podcast is for educational and entertainment purposes only and is not a substitute for professional medical, psychological, or financial advice. Ky is not a doctor or licensed therapist. Always talk with a qualified healthcare professional before making changes to your health, medication, or treatment plan. If you are in crisis, please reach out to a licensed professional or your local emergency services.

Debi Bryk has spent over eight years using functional genomics in clinical practice — and what she found changed everything about how she works with clients. In this conversation, Debi walks through the MaxGen Labs WORX panel, breaks down methylation in plain English, explains why MTHFR is only one piece of a much larger puzzle, and reveals why jumping straight to methylated B vitamins without knowing your COMT status can leave you feeling dramatically worse. She also unpacks how genetic variants in toxic response to plastics, pesticides, and seed oils can explain why some people develop chronic illness in environments that don't seem to affect others — and what you can actually do about it. Debi also explores the emerging role of lithium orotate in ADHD and Alzheimer's prevention, why low choline may be driving the mood and cognitive crisis more people experience every day, and shares her clinical framework for sequencing testing that dramatically accelerated healing and reduced costs for her clients by eliminating the guesswork entirely. Use code BEAUTIFULLYBROKEN for a discount on MaxGen Labs testing at MaxGen Labs.  Episode Highlights  [00:00] Understanding Genetic Variants and Their Impact [09:40] The Power of Genetic Testing [19:21] Methylation and Its Role in Health [29:04] Epigenetics: Environment and Gene Expression [32:17] Understanding B12 Levels and Genetic Implications [33:31] Genetic Risks: Alzheimer's and Toxins [36:33] Precision Medicine and Personal Health [38:21] Neurotransmitter Dynamics and Mental Health [38:52] The Role of MAO and COMT in Neurotransmitter Regulation [43:33] The Impact of Supplements on Mental Health [47:07] Nutritional Insights: Choline and Creatine [48:32] The Importance of Comprehensive Testing [50:09] Future of Peptide Research and Safety Concerns [54:17] Closing Thoughts on Health and Wellness   Upgrade Your Health MaxGen Labs: https://maxgenlabs.com/BEAUTIFULLYBROKEN   Code: BEAUTIFULLYBROKEN LightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794 Code: beautifullybroken Silver Biotics Wound Healing Gel: https://bit.ly/3JnxyDD 30% off with Code: BEAUTIFULLYBROKEN StemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52 Code: beautifullybroken     . CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Serotonin does far more than regulate mood — 90% of it is made in your gut, not your brain. In this episode, Nurse Doza breaks down exactly what serotonin does, why so many people are unknowingly depleted, and how to naturally restore levels through gut health, B vitamins, sunlight, and targeted supplementation.   FEATURED PRODUCT Bliss by MSW Nutrition Serotonin production depends on methylation — and if your methylation pathways are sluggish, you can be doing everything right and still come up short. Bliss is a lemon-flavored sublingual powder featuring TMG (trimethylglycine), a powerful methyl donor that directly supports the methylation reactions your body needs to synthesize serotonin and dopamine. As discussed in this episode, the MTHFR gene, B vitamins, and SAMe are all essential cofactors in serotonin production — and Bliss is formulated to address exactly that gap. Just place it on your tongue and let it absorb in seconds. One serving a day is all it takes.

In this special replay, BS Free MD host Dr. May Hindmarsh steps out from behind the microphone and into the guest chair. Originally recorded for the Hotflash Inc. podcast with host Anne-Marie McQueen, this candid conversation explores Dr. May's personal journey through menopause, hormone therapy, histamine intolerance, epigenetics, and the unexpected challenges she faced when conventional solutions didn't provide the answers she was seeking. After more than 30 years practicing medicine, Dr. May found herself navigating a complex health journey that included severe hot flashes, migraines, sleep disruption, anxiety, panic attacks, elevated heart rate, and symptoms that persisted despite hormone replacement therapy. As both physician and patient, she began asking deeper questions about genetics, hormone metabolism, mast cell activation, and individualized care. Together, Anne-Marie and Dr. May discuss the importance of critical thinking in medicine, the dangers of one-size-fits-all approaches, and why listening to your own body may be one of the most important skills in healthcare. In This Episode Why Dr. May and Dr. Tim launched BS Free MD Lessons learned from practicing medicine through the COVID era What happened when hormone therapy stopped working as expected Histamine intolerance and mast cell activation explained The role of MTHFR, COMT, and epigenetics in hormone metabolism Why some women thrive on hormone therapy while others struggle Trauma, stress, and their impact on health outcomes The growing movement toward personalized medicine How to navigate conflicting health information Learning to trust your body's signals About Dr. May Hindmarsh Dr. May Hindmarsh is a retired family physician with more than three decades of experience practicing medicine in Canada and the United States. Alongside her husband, Dr. Tim Hindmarsh, she co-hosts BS Free MD, where they challenge conventional narratives, explore emerging health topics, and encourage listeners to think critically about medicine, wellness, and personal responsibility. Original Interview This episode originally aired on the Hotflash Inc. podcast and is being republished on BS Free MD with permission. Connect with BS Free MD Website: https://www.bsfreemd.com Podcast: https://www.bsfreemd.com/podcast YouTube: https://www.youtube.com/@BSFreeMD Disclaimer The information shared in this episode is for educational and informational purposes only and should not be considered medical advice. Always consult your healthcare professional regarding your individual health needs.

I'm delighted to connect with Dr. Eboni Cornish today. She is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society, specializing in complex chronic illness with expertise in brain health, Lyme disease, autoimmune conditions, mold exposure, gut dysfunction, and women's midlife health. In our conversation, we explore how perimenopause and menopause affect the brain, as well as the roles of genetics and epigenetics. Dr. Cornish explains limbic lock, SPECT imaging, the impact of tick-borne illnesses, and co-infections, and how brain health issues can influence mental health. We also dive into the role of mold in testing, the gut-brain-immune-hormone axis, vagal tone, the estrobolome, leptin, the MTHFR mutation, and how Dr. Cornish prefers to have it tested and treated in her patients. Stay tuned for an insightful and wide-ranging conversation on brain health and women's midlife wellness. IN THIS EPISODE, YOU WILL LEARN: Why women may experience brain fog, forgetfulness, and cognitive slowing as estrogen declines How declining estrogen could make the brain more vulnerable to toxins, infections, and leaky brain How disrupted sleep, poor nutrition, and lack of oxygen (from issues like sleep apnea) can negatively affect cognition and brain health The value of continuing to learn and staying socially connected to support your cognitive health as you age How genetics can help to identify women who may be at higher risk for cognitive decline later in life. What limbic lock means How toxin overload, mold, Lyme disease, and co-infections, and unresolved stress can create a state of limbic lock  How SPECT imaging helps to explain why some people fail to improve despite multiple treatments The benefits of progesterone for supporting relaxation and improving sleep during perimenopause How declining estrogen and gut dysbiosis during perimenopause can affect the gut-brain axis Bio: Dr. Eboni Cornish Dr. Eboni Cornish is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society. She specializes in complex chronic illness, with expertise in brain health, Lyme disease, autoimmune conditions, mold toxicity, gut dysfunction, and women's midlife health. Known for her NeuroLongevity framework, Dr. Cornish takes a root-cause, brain-first approach to helping patients optimize cognitive resilience, hormone balance, and long-term wellness. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book. The Midlife Pause Supplement Line Connect with Dr. Eboni Cornish Amen Clinics On her website Instagram

The Hidden Causes of Brain Fog, Anxiety, and Chronic Illness: Mold, Parasites, Histamine, and Low Cortisol If you're exhausted, inflamed, and can't figure out why, the answer might be hiding in your histamine, your hormones, your home, or something living inside you that your doctor will never test for. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Jessica Peatross, a former hospitalist turned functional medicine powerhouse who walked away from a conventional medical career after discovering that 90% of disease traces back to lifestyle, environment, and the toxins most doctors ignore. After graduating magna cum laude and earning her medical degree from the University of Louisville, Dr. Jess pursued training in functional medicine, nutrigenomics, and alternative therapies, and now helps thousands of patients reverse chronic illness through her KillBindSweat method and WellnessPlus app. She is also the formulator and CMO of Aegis Formulas and a leading voice at international health conferences. If chronic illness, mold toxicity, or hormonal chaos is on your radar, she is the person you want in your corner. Together, Dave and Dr. Jess go deep into the hidden drivers of mystery symptoms that functional medicine is finally starting to crack open. They cover why low cortisol is more dangerous than high cortisol, how histamine and mast cell activation syndrome explain everything from anxiety and brain fog to endometriosis and POTS, and why most "Lyme disease" is actually undiagnosed mold toxicity. They also break down the parasite epidemic hiding in plain sight across the United States, the B vitamin mistake making millions of people sicker, and why your metabolism, mitochondria, and mental health are all downstream of things your standard lab panel will never catch. This episode also gets into the real story behind Dr. Jess surrendering her California medical license rather than comply with a system she believed was working against patient health. Her firsthand account of the medical board process is something every person who cares about medical freedom needs to hear. You'll Learn: Why everyone who is chronically sick has a low cortisol awakening response and what to do about it How histamine drives anxiety, racing thoughts, palpitations, bloating, skin issues, and hormonal chaos Why 90% of people diagnosed with Lyme disease actually have toxic mold and how to test for both The parasite epidemic in the U.S. and why standard testing misses most of it How the spike protein reactivates dormant viruses and feeds the histamine loop behind long COVID Why synthetic B6 causes the very neuropathy it is supposed to fix, and what to take instead The cortisol, adrenaline, and blood pressure connection that explains "wired but tired" How progesterone stabilizes mast cells and why estrogen dominance fuels inflammation and reactivity Why Dave Asprey uses low-dose cortisol, dexamethasone, and modafinil as part of his daily performance stack The mold binders that actually work, and which popular ones can harm hypermobile people How nicotine at low doses blocks spike protein from ACE2 receptors and protects the brain What the MTHFR gene, methylation, and folic acid have to do with breast cancer, depression, and estrogen detox Thank you to our sponsors! - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. - Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order. -Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it outDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Jessica Peatross, functional medicine, mast cell activation syndrome, histamine intolerance, long COVID brain fog, mold toxicity, chronic Lyme disease, parasite testing, low cortisol, cortisol awakening response, MTHFR methylation, B6 toxicity, P5P, folinic acid, estrogen dominance, progesterone therapy, spike protein reactivation, Epstein-Barr reactivation, POTS, wired but tired, Kill Bind Sweat, WellnessPlus, vaccine exemptions, mold binders, nicotine ACE2, adrenal insufficiency, RCCX gene Resources: • Go to https://drjessmd.com/ and use code ‘DRJESS' at checkout • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:33 – Releasing Medical License 03:21 – Chronic Illness Root Causes 05:00 – Hospital Nutrition 08:11 – Dave's Health History 10:22 – Parasites 20:02 – Nicotine 23:19 – Low Blood Pressure & Minerals 28:09 – B Vitamins & Methylation 33:45 – Autism & Genetics 40:13 – Toxic Mold 43:11 – ADHD Misdiagnosis 48:27 – Histamine & Mast Cells 50:56 – Long COVID & Spike Protein 58:56 – Cortisol 1:03:56 – Lyme Disease 1:09:58 – Mold Testing & Binders 1:16:37 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today's clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. Listen to the full episode on iTunes Joanne Kennedy is a highly experienced Naturopath and specialist in MTHFR, Methylation and Histamine Intolerance. Joanne runs a successful clinical practice in Sydney, Australia and also caters to patients worldwide through online consultations. Could your migraines or skin issues be tied to histamine levels? What are the hidden factors contributing to your symptoms, and how can you take control? With practical strategies and real-life examples, Joanne shares insights that promise to transform your understanding of your health. In this episode, we uncover: How histamine intolerance is linked to hormone imbalances like estrogen dominance. Why digestive health plays a critical role in managing histamine levels. How certain foods and environmental factors trigger histamine reactions. The surprising connection between histamine and neurological symptoms like migraines. Why perimenopause can be a turbulent time for women with histamine issues. Tune in to this episode to empower yourself with the knowledge you need to tackle histamine intolerance. Joanne Kennedy's insights could be the key to unlocking a healthier, more balanced life. Don't miss out! Visit Joanne's website here     Sponsors Try the power of copper peptides on your skin today and get 20% off your order with coupon code km20 here.     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

In this Ask Me Anything episode, Dr. Will Cole and his team answer listener questions on canker sores (and when they're a sign of something more), MCAS and mold toxicity in a school classroom, autoimmune thrombocytopenia in a 23-year-old naturopathic medical student with Hashimoto's and PCOS, and whether cast iron skillet seasoning is actually a health concern. They also cover the EMF-mold connection most people haven't heard of, blood-building foods and peptides for autoimmune platelet issues, and the right oils to season with based on smoking point. Plus: the team's Sip of the Summer picks and Dr. Cole's mason jar mocktail recipe. For all links mentioned in this episode, visit www.drwillcole.com/podcast.Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Find out more at apple.com/health. This message was brought to you by Apple and AT&T. Apple Watch is not a medical device and should not be used as a substitute for professional medical advice. Head to MANUKORA.com/WILLCOLE to save up to 31% plus $25 worth of free gift swith the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook.Refresh your wardrobe with Quince. Go to Quince.com/willcole for free shipping and 365-day returns. Now available in Canada, too.Text ABW to 64000 to get 20% off all IQBAR products, plus FREE shipping. Message and data rates may apply.To learn more and get 20% off your order, visit ActiveSkinRepair.com and use code: WILLCOLE . You can also find Active Skin Repair on Amazon and at your local CVS.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you are a woman in midlife who is exhausted, foggy, losing your hair, and being told it is just aging — this episode is going to change how you look at your body forever. I sat down with Julie Sawaya, the co-founder of Needed, and what I learned blew my mind. Julie is a trained nutritionist with a Stanford MBA. She was doing EVERYTHING right — farmer's market every Sunday, nutrition certifications, incredibly intentional about every bite. And then she tested herself. Almost every nutrient came back in the red zone. If two trained nutritionists were massively depleted, what is happening to the rest of us? Here is the kicker. The nutrition standard we are all measured against — the RDA — was created in 1941. For men. Going to war. Based on the minimum needed to keep troops from getting sick. That is the floor we are still being measured against in 2026. As women. In midlife. Going through one of the most nutritionally demanding phases of our lives. Ninety-five percent of women are nutritionally depleted. Ninety-seven percent of pregnant women take a prenatal vitamin and are STILL depleted. And nobody is connecting the dots between pregnancy, postpartum, and perimenopause as one long depletion pipeline. We go DEEP on: The 1941 RDA standard, why it was built for wartime men, and why it is still failing women today The depletion pipeline: how pregnancy, postpartum, and perimenopause stack on top of each other and most women never get to refill the tank CHOLINE — the nutrient behind midlife brain fog that almost nobody is talking about (and the brand new April 2026 fMRI study showing a single dose improved working memory connectivity within three hours) Omega-3 and the midlife brain — why 89% of US adults are in the high cardiovascular risk range and why plant-based sources alone do not cut it Magnesium — the most Instagrammed supplement in the world right now, and why most women are taking the form their body literally cannot absorb The supplement trap: folic acid vs. methylfolate, magnesium oxide vs. glycinate, cyanocobalamin vs. methylcobalamin — and why 40% of us cannot even process the cheap forms because of an MTHFR variant Red flags and green flags to look for the next time you flip over a supplement bottle Why the protein RDA is laughably low for midlife women, and what we actually need to preserve muscle as estrogen declines The "repletion not restriction" reframe — why midlife is the time to add MORE of the right things, not eat less Your action plan for this week: how to get a nutrient panel, what to look at on your labels, and the food-first changes you can start tomorrow morning This is not a thyroid 101. This is not a supplement infomercial. This is the conversation I wish every midlife woman was given the day she started feeling like something was off. You are not broken. You are not crazy. You are not just aging. You may be running on accumulated nutritional debt that nobody told you to repay. That changes today. Use code NATALIEJILL for 20% off your first order at https://needed.sjv.io/c/5810852/1770238/20859    Connect with Julie Sawaya and Needed: Website: thisisneeded.com and use code NATALIEJILL for 20% off your first order Instagram: @needed Backed by 15,000+ practitioners worldwide Connect with Natalie: Instagram: @nataliejillfit Newsletter and resources: nataliejillfitness.com Midlife Conversations is the podcast made for midlife women who refuse to accept "you are just getting older" as an answer APPROXIMATE TIMESTAMPS: 00:00 — The wake-up call: two trained nutritionists, both in the red zone 06:00 — Where the RDA actually came from (spoiler: 1941, wartime, men) 12:00 — The depletion pipeline: pregnancy to perimenopause as one continuum 18:00 — The forgotten gap between postpartum and perimenopause 25:00 — Choline: the nutrient behind midlife brain fog nobody is talking about 32:00 — Omega-3 and the midlife brain: why most women are not getting close 38:00 — Magnesium forms: why the cheap one in your multivitamin is barely doing anything 42:00 — The supplement trap: what is actually in your generic multivitamin 48:00 — Red flags and green flags on a supplement label 55:00 — Protein in midlife: why the RDA is wrong and what you actually need 62:00 — Repletion, not restriction: what an ideal midlife day of eating looks like 65:00 — Your action plan for this week   Thank you to our show sponsors:  QUANTUM UPGRADE: Try Quantum Upgrade completely free for 15 days—no credit card required. Use code NATALIEJILL at checkout on https://quantumupgrade.io/start  Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com   Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit   For advertising inquiries: https://www.category3.ca/  Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen.  Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.

298: I'm joined by Dr. Ben Lynch to unpack a topic that's widely misunderstood when it comes to health, anxiety, and pregnancy: methylation and the role of folate vs. folic acid. We talk about MTHFR, why some people feel worse on certain supplements, and how common prenatal advice may not work for everyone. This episode explores how to better support your body, your brain, and your future health by understanding what you're actually taking and why it matters. Topics Discussed: → MTHFR & Methylation → Folic Acid vs. Folate → Vitamins & Anxiety → Prenatal Vitamins → Pregnancy & Baby Development → Brain Health → Lifestyle & Environmental Factors Sponsored By: → Our Place | Stop cooking with toxic cookware, and upgrade to Our Place today. Visit https://fromourplace.com/REALFOODOLOGY and use code REALFOODOLOGY for 10% off sitewide. With a hundred-day risk-free trial, free shipping and returns, you can experience this game-changing cookware with zero risk. → Just Thrive | Get your health in check and save 20% on your first order at https://justthrivehealth.com/REALFOODOLOGY → Manukora | Head to https://manukora.com/REALFOODOLOGY to save up to 31% plus $25 worth of free gifts with the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook! → Timeline | Timeline's clinically proven formula is now available at a new, lower price. Mitopure now starts at $79, when you go to https://timeline.com/REALFOODOLOGY → Cowboy Colostrum | Get 25% Off Cowboy Colostrum with code REALFOODOLOGY at https://cowboycolostrum.com/realfoodology Timestamps:  → 00:00 Introduction → 01:00 MTHFR & Methylation Explained → 04:00 What Methylation Does in the Body → 08:00 Why Methylated Vitamins Can Cause Anxiety → 12:00 How to Approach Supplements (Bio-Individuality) → 23:00 Methylation, Pregnancy & Baby Development → 35:30 Folic Acid vs Folate → 48:00 Brain Health & Nutrient Deficiency → 1:10:00 Morning Sickness, Histamine & DAO → 1:14:00 Matcha, Green Tea & Folate → 1:16:00 Why Vitamins Can Make You Feel Worse → 1:19:00 Tylenol, Glutathione & Pregnancy Show Links: → realfoodology.com Check Out Ben: → Instagram Check Out Courtney:  →⁠⁠ ⁠LEAVE US A VOICE MESSAGE⁠⁠⁠ → ⁠⁠ ⁠Check Out My new FREE Grocery Guide!⁠⁠⁠ → ⁠⁠ ⁠@realfoodology⁠⁠⁠ →⁠⁠ ⁠⁠PEOPLE VS THE POISON - Sign up now!⁠⁠⁠⁠⁠⁠ → ⁠⁠ ⁠www.realfoodology.com⁠⁠⁠ → ⁠⁠ ⁠My Immune Supplement by 2x4⁠⁠⁠ → ⁠⁠ ⁠Air Dr Air Purifier⁠⁠⁠ → ⁠⁠ ⁠AquaTru Water Filter⁠⁠⁠ → ⁠⁠ ⁠EWG Tap Water Database⁠⁠⁠  Produced By: Drake Peterson Learn more about your ad choices. Visit megaphone.fm/adchoices

How-to lead your family in their health journey from a husband who's doing it. From the basics of blood work to peptides or even testing for the MTHFR gene mutation, Nate Graville, founder of Geviti helps you get ahead of disease before it starts.Thank you to our sponsors!TOOTH PILLOW: Use code "ALEXCLARK" for a free video review upgradeA'DEL NATURAL COSMETICS: Use code "ALEX" for 25% off first time ordersBLDG ACTIVE SKIN REPAIR: Use code “ALEX” for 20% off your orderBRANCH BASICS: Use code "ALEX15" for 15% off Starter KitsCROWDHEALTH: Use code “CULTURE” to get your first three months for only $99/monthWILD PASTURES: Get an exclusive discount on your next orderOur Guest:@gogeviti's Nate GravilleNate's Links:GEVITI WEBSITE Use code "ALEX" to get 20% offGoGeviti IGNate's IGNate's XFOLLOW ALEX:Instagram |⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @realalexclark⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram |⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@cultureapothecary⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook |⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @realalexclark⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠X |⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @yoalexrapz⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube |⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @RealAlexClark⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Spotify |⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Culture Apothecary with Alex Clark ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Apple Podcast |⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Culture Apothecary with Alex Clark⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Subscribe to ‘Culture Apothecary' on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Apple Podcasts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Spotify⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. New episodes drop 6pm PST/ 9pm EST every Monday and Thursday.DISCLAIMER: This content is for informational purposes only and is not medical advice. Always talk to a qualified healthcare professional for any health-related questions or decisions.

#956: Join us as we sit down with Victoria Thain Gioia – the Co-Founder and CEO of Perelel, the first OB/GYN-founded vitamin company redefining pre- and postnatal health. Victoria is on a mission to give women access to doctor-formulated, research-backed supplements that are  tailored to every stage of their hormonal journey. In this episode, Victoria gets candid about the importance of third-party testing for safety, the benefits of creatine for women, opens up about postpartum struggles, shares practical supplement routines for every stage of life, and optimizing female muscle health amidst hormonal fluctuations. She also breaks down the importance of methylated folate over folic acid, especially for those with the MTHFR gene mutation, and shares actionable tips women can implement immediately for better health and vitality.   To Watch the Show click HERE   For Detailed Show Notes visit TheBossticks.com   To connect with Perelel click HERE   To connect with Lauryn Bosstick click HERE   To connect with Michael Bosstick click HERE   Read More on The Skinny Confidential HERE   Head to our ShopMy page HERE and LTK page HERE to find all of the products mentioned in each episode.   Get your burning questions featured on the show! Leave the Him & Her Show a voicemail at +1 (512) 537-7194.   This episode is sponsored by Perelel Visit http://perelelhealth.com/skinny and use code SKINNY for 20% off your first order. Produced by Dear Media