Podcast appearances and mentions of John A Kellum

There is enormous heterogeneity in clinical outcomes and severity of septic shock, with some patients needing only supportive care in the ICU and others progressing to multiorgan system failure and death. How can clinicians identify patients at higher risk of death? In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Marilyn Bulloch, PharmD, BCPS, FCCM, is joined by John A. Kellum, MD, FCCM, to discuss high endotoxin activity as a possible endotype for septic shock. Dr. Kellum's article, “Organ Failure, Endotoxin Activity, and Mortality in Septic Shock,” was published in the September 2025 compendium of Critical Care Explorations. Dr. Kellum is a professor and director of the Center for Critical Care Nephrology, as well as vice chair for the Department of Critical Care Medicine, at the University of Pittsburgh in Pittsburgh, Pennsylvania, USA. The study used a novel biomarker called the endotoxin activity assay (EAA) to detect endotoxin in the blood. While the EAA is not good at identifying patients who are at risk for sepsis, Dr. Kellum said that, when combined with organ failure, it identifies patients at high risk for endotoxic septic shock. In the study, these patients had a mortality rate of 60%. Neither the EAA nor the anti-endotoxin therapy is readily available. And, although endotoxic septic shock is rare, occurring in only a quarter of patients with septic shock, Dr. Kellum hopes that, through precision medicine, segmenting this population into treatable subgroups may allow better diagnostics and opportunities to develop or repurpose therapies in the future. This episode is sponsored by Prenosis. Resources referenced in this episode: Organ Failure, Endotoxin Activity, and Mortality in Septic Shock (Molinari  L, et al. Crit Care Explor. 2025;7:e1308) Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis (Seymour CW, et al. JAMA. 2019;321:2003-2017) Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study (TIGRIS) (ClinicalTrials.gov. ID NCT03901807. Last update posted January 9, 2026)

Perioperative urine output is a vital sign which can have a very significant impact on outcomes. This discussion emphasises the importance of monitoring it and using the data accordingly. It then moves further into permissive oliguria within an enhanced recovery protocol. This shows no difference in creatinine values and patients are not reporting that they feel uncomfortable or thirsty as a result. Presented by Professor Monty Mythen and Dr Joff Lacey featuring guests Dr Tim Miller from Duke University Medical Centre and John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh. -- Like this, want more? This conversation is taken from a longer piece, which you can find in full here: https://www.topmedtalk.com/ebpom-2017-pod-one-live-from-london/ The above is complimented well by this podcast, which looks at some of the bigger trials that have taken place recently in the perioperative field: https://www.topmedtalk.com/ebpom-london-2018-any-answers-part-3-the-big-trials/

This piece provides "a thumbnail sketch summary of the fluid debate". Challenging the "prevailing wisdom" regarding fluid management, the kidney and volume overload; "as a young Doctor you sort of got the impression that if you got the kidney to handle a lot of fluid somehow it would be happier". Sodium and volume overload are in fact issues and extra work for the kidney and have tended to cause more difficulties than they solved. Presented by Professor Monty Mythen and Dr Joff Lacey with guest John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh. The TopMedTalk team love reading feedback from our listeners, join in the debate and send us an email: contact@topmedtalk.com -- Like this, want more? This conversation is taken from a longer piece here: http://www.topmedtalk.com/ebpom-2017-pod-one-live-from-london/ Also, this talk regarding nephrology, gets into more detail here: https://www.topmedtalk.com/periop-sig18-goal-directed-therapy-to-prevent-acute-kidney-injury/

Should we still measure urine output? How useful is permissive oliguria? Presented by Professor Monty Mythen and Dr Joff Lacey featuring guests Dr Tim Miller from Duke University Medical Centre and John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh.

Professor John Kellum gives a thumbnail sketch summary of the fluid debate.   Presented by Professor Monty Mythen and Dr Joff Lacey with guest John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh.   Join in the debate: contact@topmedtalk.com   This conversation taken from a longer piece here: http://www.topmedtalk.com/ebpom-2017-pod-one-live-from-london/

Should we still measure urine output? How useful is permissive oliguria? Presented by Professor Monty Mythen and Dr Joff Lacey featuring guests Dr Tim Miller from Duke University Medical Centre and John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh.

Professor John Kellum gives a thumbnail sketch summary of the fluid debate.   Presented by Professor Monty Mythen and Dr Joff Lacey with guest John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh.   Join in the debate: contact@topmedtalk.com   This conversation taken from a longer piece here: http://www.topmedtalk.com/ebpom-2017-pod-one-live-from-london/

In this piece find out how renal injury biomarkers can offer practitioners and patients hope. Presented by Professor Monty Mythen and Dr Joff Lacey featuring guests John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh and Dr Tim Miller from Duke University Medical Centre. Join in the debate: contact@topmedtalk.com This piece taken from a longer conversation to be found here: http://www.topmedtalk.com/ebpom-2017-pod-one-live-from-london/

Kyle Enfield, MD, speaks with John A. Kellum, MD, MCCM, about his talk presented at the 46th Critical Care Congress in Honolulu, Hawaii entitled, Are Biomarkers Ready for Prime Time?

Kyle Enfield, MD, speaks with John A. Kellum, MD, MCCM, about his talk presented at the 46th Critical Care Congress in Honolulu, Hawaii entitled, Are Biomarkers Ready for Prime Time?

Should we still measure urine output? How useful is permissive oliguria? Presented by Professor Monty Mythen and Dr Joff Lacey featuring guests Dr Tim Miller from Duke University Medical Centre and John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh.   Join in the debate: contact@topmedtalk.com This taken from a longer conversation on the subject of perioperative nephrology to be found here: http://www.topmedtalk.com/ebpom-2017-pod-one-live-from-london/

How do cell cycle arrest biomarkers offer hope? Presented by Professor Monty Mythen and Dr Joff Lacey featuring guests John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh and Dr Tim Miller from Duke University Medical Centre.   Join in the debate: contact@topmedtalk.com   This piece taken from a longer conversation to be found here: http://www.topmedtalk.com/ebpom-2017-pod-one-live-from-london/

Professor John Kellum gives a thumbnail sketch summary of the fluid debate. Presented by Professor Monty Mythen and Dr Joff Lacey with guest John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh.   Join in the debate: contact@topmedtalk.com   This conversation taken from a longer piece here: http://www.topmedtalk.com/ebpom-2017-pod-one-live-from-london/

Reactions to one of the big take away points of EBPOM 2017, intraoperative hypotension lower than 65 mmHg appears to show a close correlation to terrible, sometimes fatal, outcomes. Presented by Professor Monty Mythen and Dr Joff Lacey featuring guests Dr Tim Miller from Duke University Medical Centre and John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh.   Join in the debate: contact@topmedtalk.com   This piece taken from a longer conversation to be found here: http://www.topmedtalk.com/aser-ebpom-2017-pod-two-live-from-washington-dc/    

This discussion, recorded on day one of EBPOM 2017, a truly international gathering with many countries represented. The  Intraoperative hypotension is discussed. New information regarding cognitive function for patients raises big questions. Should shared decision making be re-evaluated?   The team then discuss the Perioperative Quality Initiative (POQI) and new information regarding intraoperative hypotension. How rapidly should you attend to fluctuations? What is an appropirate response nowadays?   The subject of perioperative nephrology is discussed, including topics such as the fluid challenge, urine output, biomarkers and the timing of renal replacement therapy.   Presented by Professor Monty Mythen and Dr Joff Lacey featuring guests Dr Tim Miller from Duke University Medical Centre and John A. Kellum, Tenured Professor, Critical Care Medicine from The University of Pittsburgh.   Join in the debate: contact@topmedtalk.com

John A. Kellum, MD, FCCM, discusses how one uses RIFLE to take care of patients with acute kidney injury (AKI).