Podcasts about Medicine

What is the BEST medical side effect? WE GOT THIS.

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice. Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise. This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology. You'll Learn: Why precision medicine outperforms population-based health strategies for human performance How to layer genomics, transcriptomics, and proteomics into one complete biological picture Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits The real story on metformin, peptides, and which supplements actually move the needle How AI can help you understand your own biology and act on it faster Why biohacking precision beats random stacking every time Thank you to our sponsors! • Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order. • BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com • Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. • Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs Resources: • Learn More About Anil's Work And the Institute For Human Optimization At: https://ifho.org/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:53 – Intro to Precision Medicine 01:58 – Dr. Bajnath's Holistic Health Journey 05:03 – Pharmaceuticals vs. Supplements 07:58 – Peptides and Longevity Molecules 10:34 – Sexual Health and Vitality 13:56 – Vascular Health and Blood Flow 15:14 – Multi-Omics Approach 19:03 – DNA and Genomics 22:17 – Transcriptomics and RNA 24:24 – Proteomics and Inflammation Markers 32:00 – The Human Exposome 34:55 – Key Health Biomarkers 36:58 – Cell Membrane Dynamics 40:28 – Biological Investment Strategy 41:53 – Life Extension Possibilities 48:52 – Bioenergetics and Mitochondria 49:47 – Quantum Medicine and the Future 51:33 – Vagal Nerve Stimulation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Tayne, host of the Altar Call MAFS podcast, joins me to talk about Love Is Blind, Kenny from Love Island USA season 6 being terrible, the official Real Housewives of New York cast, Married to Medicine, Real Housewives of Potomac and more! ⁠ACCESS AD-FREE, BONUS AND VIDEO EPISODES BY BECOMING A PATRON HERE⁠⁠⁠⁠ Follow Tayne on⁠⁠⁠ ⁠Instagram⁠⁠⁠⁠ and listen to her⁠⁠⁠ ⁠podcast⁠⁠⁠ Follow me on⁠⁠⁠⁠ ⁠Instagram⁠⁠⁠⁠⁠ ⁠Support the show⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Tayne, host of the Altar Call MAFS podcast, joins me to talk about Love Is Blind, Kenny from Love Island USA season 6 being terrible, the official Real Housewives of New York cast, Married to Medicine, Real Housewives of Potomac and more! ⁠ACCESS AD-FREE, BONUS AND VIDEO EPISODES BY BECOMING A PATRON HERE⁠⁠⁠⁠ Follow me on⁠⁠⁠ ⁠Instagram⁠⁠⁠⁠ Follow Tayne on⁠⁠⁠ ⁠Instagram⁠⁠⁠⁠ and listen to her⁠⁠⁠ ⁠podcast⁠⁠⁠ Support the show Learn more about your ad choices. Visit megaphone.fm/adchoices

The first 24 hours of a newborn's life are not just clinical — they are electric. They're where physiology meets fear and policy meets instinct, revealing just how resilient and vulnerable babies can be. In this episode, we're unpacking what happens on that first day from the golden hour and early feeding behaviors to delayed bathing and recommended care. Anna Ruman, MD, specializes in pediatrics at Children's Hospital Colorado. She is also an assistant professor at the University of Colorado School of Medicine. Christine Gold, MD, specializes in pediatric hospital medicine and is an associate professor. Some highlights from this episode include: Feeding behaviors in the first 24 hours  How pediatricians can support families before birth  Recommendations for newborn care, including medications  Helpful tips for pediatric newborn support  For more information on Children's Colorado, visit: childrenscolorado.org. 

Dr. Hoffman continues his conversation with Neil Levin, the Senior Nutrition Education Manager and a product formulator for NOW(r) Foods and Protocol for Life Balance. 

Nutritional Support for Brain Health: Lifestyle, Curcumin, Magnesium, and Key Nootropics: Nutrition educator/formulator Neil Levin from Protocol for Life Balance details nutritional support for brain health amid skepticism about “brain-boosting” supplements, citing a preprint randomized controlled trial using a multifaceted lifestyle plan (diet, exercise, sleep) plus targeted supplementation that reportedly improved and even reversed symptoms in people with mild cognitive impairment. They contrast lifestyle strategies with costly, side-effect-prone injectable “plaque-buster” Alzheimer's drugs and notes debate about whether amyloid is a root cause or byproduct. The conversation highlights inflammation and oxidation as major aging-related brain threats and reviews supplements including a brain-targeted curcumin (discussing bioavailability, delivery methods, blood–brain barrier crossing, and claims of lowering beta-amyloid protein), magnesium L-threonate for CNS delivery, phosphatidylserine and acetylcholine support (including huperzine), ginkgo and gotu kola, glutamine/GABA pathways, creatine, omega-3s (DHA/EPA and algae sources), B vitamins, acetyl-L-carnitine, alpha-lipoic acid, and cocoa flavanols, plus concerns about supplement industry enforcement.

An auditorium full of medical students at Albert Einstein College of Medicine listened intently as ninety-year-old Ruth Gottesman spoke. As she concluded, Ruth announced—to the students’ gasps, cheers, and pandemonium—that she was donating $1 billion so that they could finish their education tuition free. This is the largest donation ever given to a medical school. Yet in the interviews that followed, you would have thought that Gottesman was the one receiving the gift. She expressed joy, delight, and honor to be able to give her money away. Proverbs tells us that this is how generosity works. The one who “gives freely,” far from being left diminished or bereft, finds blessings they hadn’t anticipated (11:24). When we freely open our hands to others, we’re somehow left with something more—not less. “Whoever refreshes,” Scripture says, “will be refreshed” (v. 25). We’re tempted to tightly grip whatever we have, fearful that we’ll be taken advantage of or left with nothing. God’s economy works differently, however. Jesus went a step further, stating that it’s “more blessed to give than to receive” (Acts 20:35). We can be generous with our lives and our resources, offering what we have to others in need. And then, in return we’ll find that we end up receiving too. There’s plenty for everyone in God’s kingdom.

Adam and Jeff talk about the radical medical beliefs of our probable next Surgeon General, Trump's flip-flopping on the "obliteration" of Iran's nuclear program, ICE pepper spraying a mom and three kids inside a moving vehicle, and so much more!Show notes: https://youdontlike.link/klz

In this episode of Translating ADHD, Asher and Dusty discuss the crucial role of fun and joy as essential tools for managing ADHD. They explore how many people with ADHD fall into the trap of endless to-do lists and feel they must “earn” their fun, which leads to burnout, depletion, and a life spent in procrastination or the “dark playground” — a place of unproductive scrolling and disengagement. By prioritizing fun and incorporating playfulness into daily routines, individuals can create the mental capacity and motivation needed to tackle tasks more effectively. Dusty shares a personal story about transforming the mundane task of taking calcium pills into a joyful ritual, highlighting how small changes in aesthetics and mindset can make a significant difference. The hosts also introduce a framework called the "Forces of Fun," breaking down fun into four categories: create, consume, commune, and cavort. They emphasize the importance of making space for pure fun, even when it feels difficult due to executive dysfunction or burnout. Strategies such as pre-deciding activities or creating dopamine menus help overcome barriers to engaging in enjoyable activities. The episode concludes with a reminder that fun is a birthright and an essential part of self-care for people with ADHD—not a reward to be earned but a necessary part of living well. Episode links + resources: Join the Community | Become a Patron Our Process: Understand, Own, Translate. About Asher and Dusty For more of the Translating ADHD podcast: Episode Transcripts: visit TranslatingADHD.com and click on the episode Follow us on Twitter: @TranslatingADHD Visit the Website: TranslatingADHD.com

Everyone is at risk of breast cancer. Some are more at risk than others due to hereditary factors – such as a family history of cancers – and lifestyle choices that affect our overall health. Knowing your risk of breast cancer can help you decide what steps to take to lower your risk. Joining me today is Dr. Jennifer Ligibel, a Susan G. Komen Scholar and Komen grantee, Professor of Medicine at Harvard Medical School, Senior Physician at the Dana-Farber Cancer Institute and an expert on the impact of lifestyle factors, cancer risk and outcomes. Through more than a dozen lifestyle intervention trials, Dr. Ligibel has evaluated the impact of exercise, weight loss, fitness, body composition and quality of life in cancer patients and survivors.

Sugar restriction during the first 1000 days of life may slash heart risk decades later; Are some people more genetically-adapted to the cold? While GLP-1 drugs may shrink muscle, new study confirms natural weight loss diets don't. Should strength assessments be added to routine physicals to forecast risk of dying? For gut health, take your microbiome for a run! Strontium safety and effectiveness; What are dietitians missing about GLP-1 drugs.

The MAHA backlash over RFK Jr.'s about-face on glyphosate; Amid the partisan divide, Making America Healthy Again cuts across party lines; New study confirms effectiveness of personalized lifestyle interventions for reversing dementia; After an allergic reaction to the Covid shot, is it safe to take other vaccines? Some GLP-1 users are developing scurvy; Six lifestyle hacks that augment weight loss drugs' cardio benefits.

In this episode of Parallax, Dr Ankur Kalra speaks with Dr Sameed Khatana, Assistant Professor of Medicine at the University of Pennsylvania and clinical cardiologist at the Philadelphia VA Medical Center. Their conversation examines the growing connection between environmental factors and cardiovascular health. Dr Khatana explains why conditions like air quality and temperature represent important determinants of cardiovascular outcomes. He shares observations from his Philadelphia practice: patients unable to exercise outdoors during extreme heat, medication challenges for those on diuretics during heatwaves, and economic pressures that force difficult choices between cooling costs and other necessities. The discussion explores both clinical interventions and systemic solutions, including programs like LIHEAP (Low Income Home Energy Assistance Program) and municipal heat action plans. Dr Khatana presents research showing that vulnerable populations—particularly older patients with multiple cardiovascular risk factors—face disproportionate impacts from environmental stressors. Dr Khatana encourages cardiologists to engage with this evolving aspect of patient care, advocating for collaboration between professional societies, environmental scientists, and policymakers to develop effective strategies that support cardiovascular health in changing environmental conditions. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

Welcome to another episode of the Sustainable Clinical Medicine Podcast! Dr. Dhaval Desai, an Atlanta-based internal medicine–pediatrics physician and former hospitalist director, shares his path from studying economics and Spanish and teaching high school to training abroad and leading a 30-physician hospitalist group at Emory St. Joseph's with a split clinical/administrative role. He describes how COVID-era pressures and a new baby contributed to burnout, sleep and mood issues, and seeking therapy and medication, later deepening his advocacy through a memoir and work with the Dr. Lorna Breen Heroes Foundation, noting about 400 U.S. physicians die by suicide annually. After being rejected for a chief wellbeing officer role and facing institutional limits on speaking publicly, he hired an executive coach and resigned, concluding loyalty can hold physicians back. He pivoted to direct primary care by purchasing a retiring physician's practice, citing autonomy, fewer patients, and reduced bureaucracy as key to preventing burnout. Here are 3 key takeaways from this episode: Physician Loyalty Can Become a Career Trap: Dr. Desai learned that his loyalty to his institution, patients, and colleagues was actually holding him back from making necessary career changes. His executive coach's blunt advice - "Nobody is going to give a shit if you leave tomorrow" - proved true when he resigned. Healthcare systems will move on, regardless of individual contributions, and physicians need to recognize when loyalty is preventing them from pursuing fulfillment. Institutional Control Compromises Professional Integrity: Large healthcare systems often restrict physicians' ability to speak freely and advocate for what they believe in, even on humanitarian issues. Dr. Desai's experience being called in after writing an op-ed about ICE raids in hospitals showed how "the firm" can force physicians to compromise their values. This institutional pressure, combined with being passed over for the Chief Wellbeing Officer position, revealed that systems may pigeonhole physicians regardless of their capabilities. Direct Primary Care Offers Control and Prevents Burnout: Transitioning to a Direct Primary Care (DPC) model allowed Dr. Desai to reclaim control over his schedule, patient panel size, and work-life balance. By eliminating insurance billing bureaucracy and middle management, he now spends 30-60 minutes per patient visit instead of documenting for 6 hours daily. This autonomy - combined with ongoing therapy and medication - has eliminated the "dread of going to work" and allows him to pursue advocacy, media, and other passions without institutional gatekeeping. Meet Dr. Dhaval Desai: Dr. Dhaval Desai is a dual board-certified Internal Medicine and Pediatrics physician who transitioned from hospital leadership into Direct Primary Care to practice medicine with deeper connection and purpose. He is the author of "Burning Out on the COVID Front Lines..." and host of the podcast SEEN IN FULL, where he explores burnout, identity, advocacy, and the human experience in modern work and life. Connect with Dr. Dhaval Densai:

Fertility isn't just about reproduction; it's a powerful indicator of overall health, hormonal balance, and resilience.In this episode of A Voice and Beyond, I'm joined by Dr Marina Straszak-Suri, a highly respected OBGYN and an assistant professor at the Faculty of Medicine at the University of Ottawa for over 30 years, providing care to women during all stages of life. Drawing on both modern reproductive medicine and holistic, evidence-based lifestyle strategies, Dr Marina offers clarity and empowerment in an area where many feel overwhelmed or unheard.In this deeply informative and reassuring conversation, we explore how to:Decode your cycle and understand your body's signalsImprove egg and sperm quality through proven lifestyle shiftsNavigate stress, sleep, nutrition, and environmental toxinsExplore natural supplements that actually make a differenceRestore your sense of agency and hope, no matter your age or diagnosisWhether you're planning for pregnancy, preserving your options, or simply wanting to understand your body on a deeper level, this episode offers clarity, compassion, and practical insight.Find Marina Here:Website: https://drmarinaobgyn.com/linkedin: https://www.linkedin.com/in/marina-straszak-suri-md-frcsc-9b32351a/?originalSubdomain=caFB: https://www.facebook.com/profile.php?id=100064823585003Insta: https://www.instagram.com/dr.marina.obgyn?igsh=MTJ4ZHJjbXp0OWU1Resources:Free report – "Seven Tips to Optimize Your Chance of a Healthy Pregnancy" at https://drmarinaobgyn.com/freereportFind Marisa online: Website: https://drmarisaleenaismith.com/ LinkedIn: https://www.linkedin.com/in/drmarisaleenaismith/ Instagram: https://www.instagram.com/drmarisaleenaismith/ Facebook: https://www.facebook.com/marisa.lee.12 YouTube: https://www.youtube.com/@avoiceandbeyond3519/videos Resources: MLN Coaching Program: https://drmarisaleenaismith.com/mentoring/ Schedule a Free Clarity Call: https://calendly.com/info-56015/discovery Gratitude Journal: https://drmarisaleenaismith.com/product/in-gratitude-my-daily-self-journal/ Download your eBook: Thriving in a Creative Industry: https://drmarisaleenaismith.com/product/ebook-thriving-in-a-creative-industry-dr-marisa-lee-naismith/ Like this episode? Please leave a review here - even ...

A new center for the study of chronic infectious diseases aims to develop treatments for illnesses like Valley fever, tuberculosis, HIV, and Long COVID that disproportionately affect South Texas communities. Led by Dr. Barbara Taylor, the center seeks to attract top researchers and serve as a hub for clinical trials and community-focused care.

Karen explains how AI is already being used in healthcare, from helping find polyps during colonoscopies to speeding documentation. She also covers the biggest concerns, including the possibility of errors, bias, privacy risks, and over-reliance.Visit our website itchyandbitchy.com to read blog posts on the many topics we have covered on the show.

Send a textWhat are we actually compressing during neonatal CPR? This week on The Incubator Podcast, Ben and Daphna dive into a provocative echocardiography study out of Edmonton showing that standard chest compressions in newborns likely target the right heart and great vessels — not the left ventricle. A small sample size, but a finding that anyone who ultrasounds hearts all day will instantly recognize.Daphna presents a retrospective multicenter study from Nationwide Children's on antibiotic duration for Gram-negative bloodstream infections in the NICU. Short course (≤8 days) showed no treatment failures — while 14% of infants in the long duration group developed a multi-drug resistant organism infection. Eight days versus ten: does the difference matter? The data says yes.Ben reviews a randomized controlled trial from UAB on early vitamin D supplementation in extremely preterm infants fed human milk. Eight hundred units daily for the first two weeks appears safe and effective at achieving vitamin D sufficiency — but did it move the needle on BPD? And is that even the right question to ask?Daphna brings a QI paper from Levine Children's on universal social determinants of health screening across nine pediatric divisions, achieving 92% compliance and connecting thousands of families to resources through findhelp.org. A reminder that the tools are already there — we just have to use them.The episode wraps with Ben, Daphna, and Eli discussing Colorado's landmark paid NICU leave law — the first in the nation to require employers to provide up to 12 weeks of paid leave for parents with a baby in the NICU. What does the evidence say, and how do we advocate for this in our own states?Science, equity, and advocacy — all in one episode.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Many cyclists adopt bodybuilding-style strength training in the gym, assuming it will improve power and endurance on the bike. However, research shows that heavy, low-volume strength training – and not high-rep hypertrophy training – improves cycling economy, maximal power output, and time trial performance. In this episode, Coach Jen explains why bodybuilding workouts may interfere with cycling performance and outlines evidence-based strength training principles for mountain bikers and gravel cyclists. In This Episode: The difference between hypertrophy and performance training Why excessive fatigue compromises endurance performance How heavy strength training improves cycling economy Proper rep ranges for cyclists The importance of power and neuromuscular training Research Referenced: Rønnestad, B. R., & Mujika, I. (2013). Optimizing strength training for running and cycling endurance performance: A review. Scandinavian Journal of Medicine and Science in Sports, 24(4), 603-612. https://doi.org/10.1111/sms.12104 PMID: 23914932 Aagaard, P., & Andersen, J. L. (2010b). Effects of strength training on endurance capacity in top‐level endurance athletes. Scandinavian Journal of Medicine and Science in Sports, 20(s2), 39-47. https://doi.org/10.1111/j.1600-0838.2010.01197.xPMID: 20840561 Wilson, J. M. et al. (2011). Concurrent training. The Journal of Strength and Conditioning Research, 26(8), 2293-2307. https://doi.org/10.1519/jsc.0b013e31823a3e2dPMID: 22002517 Check out these other relevant episodes: 236. How to Stay Motivated When Winter Days Get Short and Cold 231. How to Maintain Bike Fitness Without Losing Motivation this Winter 196. 5 Nutrition and Fitness Tips for Winter    Do you have nutrition and fitness goals? I’m your coach!  If you’re ready to finally make some sustainable progress, feel strong and powerful on every climb uphill, feel less pain, perform better, or lose a few extra pounds, then apply to work with me by clicking here. I work with people just like you, and you’ll see results a helluva lot faster than on your own. #ShredStrong: Our Month Starts on Monday, March 2, 2026! #ShredStrong is my year-round strength training program for mountain bikers and gravel cyclists. You can join any time you want, but why not now?! Learn more about the program and sign-up HERE!  Keywords: cyclist-specific training, gravel cycling training, mountain bike strength, cycling recovery, busy athlete training, Shred Strong podcast

A brilliant pre-med student. 521 MCAT — 98th percentile. 4.0 GPA. Published research. Primary author. Rejected by ten medical schools. If that résumé isn't good enough, what is?On The Real Story, I examine how Diversity, Equity, and Inclusion policies are reshaping medical school admissions. Across the country, schools describe “holistic review,” equity mandates, and diversity goals as central to their mission. Academic metrics are no longer the primary standard and that merit is being subordinated to ideology.We break down AAMC data, LCME accreditation shifts, pass/fail grading trends, and looming physician shortages. Medicine is not a sociology lab. When you're on an operating table, credentials matter. Excellence is not negotiable. Thank you to our sponsor: Preserve Gold - text "ASK PHIL" to 50505 and go to https://DrPhilGold.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In today's episode, we are joined by John Goldman, Founder and CEO of Rebel Health Alliance (RHA), a forward-thinking medical practice focused on optimization and longevity, using each individual's unique biology and long-term health goals as the guiding force. John launched RHA in 2023 to bridge the gap between traditional medicine and proactive, data-driven health optimization. After experiencing personal health challenges like chronic fatigue and brain fog, he became determined to address the root causes that conventional, reactive medicine often overlooks.  Today, John and his team at Rebel Health Alliance provide a highly personalized approach, leveraging advanced diagnostics, biomarker tracking, and customized medical guidance. This is designed to help busy business owners, executives, and elite athletes enhance performance, extend healthspan, and take control of their long-term well-being. Hit play to discover: Why traditional healthcare often fails high performers. The shift from reactive, disease-focused medicine to proactive health optimization. How long it takes to get into shape from no conditioning. Advanced diagnostics and biomarker tracking for precision care. How to build a long-term plan for peak performance and extended healthspan. Want to learn how Rebel Health Alliance is redefining healthcare standards in the United States through technology, personalization, and performance-driven care? Join the conversation now! Follow John on Instagram: @johngoldman__ Follow RHA on Instagram: @rebelhealth

V and Mani chat about the other Bravo shows that are SO GOOD right now! Let us convince you why The Valley Persian Style is even better than Shahs was (and the Valley honestly). GG, Reza and MJ are far from the only reasons to watch and the drama and storylines are so good. Married to Medicine is in its 12th season and it is still firing from all cylinders! Couples trip to Jamaica makes for great television. Oh and the trailer for RHOA just released and with it came new housewives and new headlines already. Do we think it'll be a great season? First impressions of the newbies? all that and (obviously) so much more! Get in the Mix!Want more of Mani and Vanessa?Vanessa- @realitea_recap (IG & Threads)Youtube https://www.youtube.com/@realitearecap2876Mani- @mixingwithmani (IG & Threads)TMWM Visuals and Ad-Free Eps- Patreon.com/mixingwithmaniThank you to This week's Sponsor: Ro --go to ro.co/mwm to support the show!

In this episode of The Brave Enough Show, Dr. Sasha Shillcutt and Dr. Sunny Smith discuss:  Being lonely in a room full of people  How to tear down the walls we build  Not believing everything we think  "We are meant to live in community with others. When we are vulnerable, authentic, and truthful, we open ourselves up for real connection."  -Dr. Sunny Smith  Dr. Sunny Smith is the Founder and CEO of Empowering Women Physicians, the most effective physician coaching program documented to date. Dr Smith brings her background as an awarded Medical Educator, Clinical Professor of Family Medicine and Public Health, and long history of being an advocate for medical student and physician wellness into the coaching space. She leads a comprehensive and collaborative coaching program, podcast, retreats, and Facebook group that seek to change the culture of medicine. Dr. Smith is the recipient of multiple teaching awards, including Humanism in Medicine, Excellence in Teaching, and Outstanding Community Leader award. Her work has been published in many peer-reviewed journals, including JAMA.  She has been in the top 1-2% of female entrepreneurs in the US for the past 6 years and has been featured in Forbes, Inc 5000, and Entrepreneur Magazine.    Brave Balance is about transforming your professional and personal life in a safe, small group setting. You will grow deep in self-awareness, set clear boundaries, and develop strong time management skills to create the work-life balance you desperately need (and deserve). Change your mindset to let unhealthy behaviors go, and create long-lasting work-life control so you can live well on YOUR terms. Brave Enough 2026 CME Conference For ten years, women have gathered at the Brave Enough Conference to step away from the demands of medicine and into a space of renewal. This anniversary year, we celebrate a decade of empowerment and sisterhood—ten years of lifting each other up, reigniting purpose, and remembering that none of us has to do this alone. Join us September 24-27, 2026 at the Omni Scottsdale Resort and Spa. Follow Brave Enough:   WEBSITE | INSTAGRAM | FACEBOOK | TWITTER | LINKEDIN Join The Table, Brave Enough's community. The ONLY professional membership group that meets both the professional and personal needs of high-achieving women.

Lindsay Rae Smith Privette, author of "The Surgeons Battle: How Medicine Won the Vicksburg Campaign and Changed the Civil War."

Hidden Hunger: The Importance of Micronutrients: Nutritionist Leyla Muedin focuses on the critical role of micronutrients—vitamins and minerals—in overall health. Leyla highlights the global issue of 'hidden hunger,' a deficiency in essential micronutrients that silently affects billions worldwide. She explains the impact of this deficit on immune function, growth, energy metabolism, and chronic disease prevention. The discussion includes key micronutrients like vitamins A, C, D, E, B complex, iron, zinc, iodine, and selenium, and their sources. Leyla underscores the need for dietary diversity, fortification, targeted supplementation, and nutritional awareness to combat this pervasive issue. She also advises on recognizing symptoms of deficiencies and the importance of individualized nutrition plans guided by healthcare professionals.

First, meet Dr. Steiner, Chair of Pediatrics at the University of Oklahoma College of Medicine. Oklahoma Children's OU Health is the new sponsor of the Kids Marathon and we are so glad Dr. Steiner is here to chat with us about Children's health and wellbeing! Then, meet Mark Bravo! Mark has been an integral part of the OKC running community for decades. If you've run a race in Oklahoma, chances are you've heard him announcing one before! Mark works with OK Runner and helps announce at our Health and Fitness expo. Finally, hear from Jackie Levi, co-founder and Chief Strategy Officer at Haku, our registration company! We love our partners at Haku. Thinking about registering for a race? Sign up now and beat the price increase on March 4!

What if the reason you’re not healing isn’t that you need another diagnosis? 0:08 It’s that your cells aren’t receiving the right signals. Because the body doesn’t run on diagnosis, it runs on 0:16 communication. And peptides are one of the most powerful, most misunderstood 0:21 tools we have for cellular signaling, immune balance, tissue repair, gut 0:27 lining support, metabolic control, brain signaling, sleep cycles, and even sexual 0:35 wellness. Today, I’m going to do what most people won’t. Define peptides in 0:41 plain English for you. break them into categories by what they’re best at and 0:47 tell you which ones are FDA approved on the list and which ones are commonly 0:53 used off label or investigational with the evidence that actually says these 1:00 work. This is going to be a powerful episode and if you’ve ever felt like you’re hearing hype without clarity, 1:07 this one’s for you. So, as usual, grab your cup of coffee or tea and settle in 1:13 as we talk about peptides that can fit into your healing journey. We’re going 1:19 to have a short word from our sponsor. You know, we got to do that. That’s how we stay on the air here. So, we will be 1:26 right back after this. Did you know sweating can literally heal your cells? 1:32I nfrared saunas don’t just relax you. They detox your body, balance hormones, 1:37 and boost mitochondrial energy. I’m obsessed with my health tech sauna. And 1:42 right now, you can save $500 with my code at healthtechalth.com/drmuthqen25. 1:54 All right, here we go, guys. I am excited to dive into peptides with you. 2:00 So understanding peptides is foundational, right? And I’ve been 2:06 studying peptides now for about nine years. Um, and I find that they are 2:13 incredible. Um, so I want to break down for you what peptides actually are, what 2:19 they do, and some of the top peptides that are available today, and how they 2:25 can be utilized. Because I think it’s really important. And I think it’s it’s there’s a lot of confusion out there about what these things actually are and 2:32 are they safe? Are they not? When do we use them? What’s the science behind them? So, we’re going to dive in and 2:38 we’re going to talk about all things peptides. So, let’s get ready here. Here we go. So, peptides are short chains of 2:45 amino acids and they typically range anywhere from 2 to 50 amino acids and 2:51 they’re linked by peptide bonds. So think of them as the superglue that holds the amino acids together. They sit 2:58 between the amino acids and they are full proteins in terms of their size and 3:04 their complex structure. And what makes peptides particularly interesting in 3:10 medicine is their role as signaling molecules. They’re essentially the 3:15 body’s text messages carrying specific instructions to cells and tissues. And 3:21 unlike our proteins which often serve as structural roles or act as enzymes, 3:28 peptides typically function as hormones, neurotransmitters and growth factors and 3:33 they bind to specific receptors on the cell’s surfaces or within the cells and 3:39 they trigger this effect. It’s like a cascade effect of a biochemical reaction 3:45 that ultimately changes the cellular behavior. So basically, it’s changing 3:50 the way the body’s cell structure acts. And this is why peptides can be so 3:56 incredibly powerful and therapeutic when you introduce the right peptide signal. 4:02 Now, you could theoretically redirect cellular processes toward healing, 4:07 towards metabolism, immune balance, tissue repair. Any of those things can 4:14 be manipulated to do a certain thing once we add the peptide. The challenge 4:19 in peptide medicine though lies in distinguishing between those peptides that have been rigorously studied, 4:26 proven safe and effective and approved by regulatory bodies like the FDA versus 4:31 those that exist in what we call the gray zone of a promising clinical data. 4:36 But they really lack human validation so far. And this distinction is critical because the presence of a plausible 4:43 mechanism does not guarantee safety or efficacy in living humans. So, this is 4:50 really important and we’re going to dive in and look at some of the research on all of these different peptides that are 4:56 available and I’m excited to say there’s some amazing peptides being studied right now that unfortunately are not 5:01 available. But I can’t wait to see them hit the market for us because it is going to be a gamecher as far as health 5:09 and longevity. So there is a quality control issue and there is a hidden 5:14 variable in peptide medicine with this and it’s one of the most underappreciated aspects of peptide 5:21 therapy particularly for non-FDA approved peptides. It’s quality control. 5:26 When we discuss pharmaceutical medicines, we take for granted that the pill contains what the label says. Not 5:32 always true depending on where it comes from. You guys, if you’ve heard my episodes before talk about how many of our medications are made in China and 5:41 have been contaminated with other things, you will realize that that is not always true. So, just because it has 5:48 the FDA stamp of approval on the medication, it still does not necessarily mean it’s safe and we still 5:54 need to do our homework on it. So, sorry for digressing on you guys, but you know, when we get a medication, we we 6:00 think that what the amount says is what is there, doesn’t have contaminants, it’s manufactured with good 6:06 manufacturing practices. You’ll see that listed as GMP on the bottle, and it’s been stored properly, it’s been 6:12 maintained stable, and with research peptides and compounded formulations, 6:17 none of this can be assumed. So, I will share a story with you. There was a gentleman that was purchasing these 6:24 peptides online from a research facility and um did not know that they were 6:30 coming from China and he was ordering a particular growth hormone peptide and 6:35 after a little while he had he had done fine for the few first few bottles. After a little while he started having 6:42 some complications. He started getting really irritable and angry and ragy and 6:47 he didn’t quite know what was going on. And so he decided to go get some testing done. He had some blood testing done and 6:53 his testosterone level was over 5,000. So for those of you who know what testosterone level should be for a guy, 7:00 they really shouldn’t be any higher than about 1,00200 would be absolute max that we’d want to see. Now he was taking 7:06 testosterone but not to that degree. And prior to adding this peptide, his 7:12 testosterone was very stable. What they ended up finding out was the peptide that he was getting, whoever was 7:18 manufacturing it added testosterone to the peptide. They felt like if if it had growth hormone, that was great, but if 7:25 it had growth hormone and tes testosterone, all the better. And he didn’t know that. And this is the 7:31 problem that we can have with peptides if you don’t source them properly. if you’re not working with somebody that 7:37 knows how to source them and can prove that they are what they say they are. Um, I’m sure there’s a whole bunch of 7:42 studies out there too of people getting these peptides and paying hundreds of thousands of dollars for them over their 7:48 lifetime and finding out they were nothing more than just sterile water. So, you really do need to be careful 7:53 with your quality control. Now, this kind of leads us right into the next topic that we’re going to talk about and that’s the manufacturing question, 8:00 right? The FDA approved peptides are manufactured in facilities subject to 8:05 the FDA inspection rules following our GMP regulations and these facilities 8:11 must validate their manufacturing process, demonstrate consistency batch to batch, test for purity and potency. 8:18 They need to test for bacterial endotoxins and sterility and they need to maintain detailed records. So, when a 8:25 pharmaceutical company submits a drug application, the FDA inspects the manufacturing facility as part of the 8:32 approval process. If you’re getting peptides from a different country, none of that is happening. And there are some 8:38 ways for us to determine if that is what you’re getting. Typically, the rule of thumb is if your peptides are coming 8:44 with a different colored top, every one of them has a different colored top. Those are typically being sourced out of 8:49 China. I wouldn’t say that’s 100% but that’s kind of the rule of thumb that people follow. So compoundingies these 8:56 are thearmacies that make our bio identical hormones. They can make medications in any dose or strength or 9:02 route. There are thousands of them in every not that not in every state but 9:08 there are thousands of them around the country right now. So these compoundingies are registered as 503A 9:15 facilities. They do traditional compounding for individual prescriptions, right? Like they can make 9:20 thyroid, they can make LDN, they can make estrogen. You can also have a 503b 9:27 facility, which is an outsourcing facility. And these companies produce larger batches of products. They’re they 9:34 have some oversight, but they’re less stringent than for FDA approved 9:40 manufacturers. And state boards of pharmacy regulate a 503A pharmacy. And 9:45 the FDA can inspect the 503b facility, but doesn’t preapprove any of their 9:52 compounding products. So, they can inspect it, but they don’t approve them. So, research chemicals and these 9:58 suppliers operate essentially with no oversight. They explicitly market products for research use only, not for 10:06 human consumption to avoid FDA regulation. If they put that on their 10:12 product, they don’t have to comply to what the FDA is saying. And there is no required manufacturing strategies or 10:19 standards, no required testing, no required sterility assurance, and no enforcement mechanisms if products are 10:26 mislabeled or contaminated. So basically, they don’t have the liability, but that doesn’t mean that 10:31 all of them are badies or bad suppliers. It just means they don’t have to comply 10:37 to the FDA rules. Now, there are many of these companies that I’ve seen and I’ve talked to that do do a lot of this. They 10:44 do test their product for sterility. They do test their product to make sure it is what it says it is. They don’t 10:51 have to, but they do. So, if you’re going to decide to use a company that 10:56 has research only, not for human consumption, at least ask for their 11:02 proof of testing so that you know that the product you’re getting is what it says it is and that it’s clean. Because 11:08 this is where we run into the problem is in purity. So in purity peptide 11:13 synthesis can produce not just the targeted peptide but also related 11:19 peptides with deletions, substitutions, truncations or truncations of amino 11:25 acids. Sorry. And this high performance liquid we call it uh chromatography can 11:30 separate these related impurities and quality and quantify the actual target 11:35 of the peptide content. So a certificate of analysis is what you want to ask these companies for. This shows the HPLC 11:44 the testing mechanism with greater than 95% or ideally 98% purity which 11:51 indicates a higher quality product. So this certificate of analysis can be fabricated may not represent the 11:57 specific batch being sold. It happens. We need to know not everybody is honest. Not everybody, you know, does what they 12:03 say and it does what’s right. But at least you at least they’re giving you something and you have some security. 12:10 and then choose a company that was referred to by someone else that has done some homework as well. In in 12:16 commercial research, there’s independent testing and they research peptides and this has been really shocking 12:23 variability that they’ve seen. Some products contain 50% or less of the 12:29 claimed peptide and some contained primarily degradation of the product or manufacturing impurities and some 12:36 contained bacterial endotoxins at levels that could cause fever and systemic 12:42 inflammation if it was truly injected. And I would also worry with some of those problems, you know, depending on 12:48 what impurity or bacterial endotoxin was there. If you’re using a product to boost your immune system and your immune 12:54 system is already compromised, these bacterial endotoxins can actually make you sicker instead of what you want it 13:02 to do, which is making you better. So, sterility is always an issue with anything that is manufactured, 13:08 especially things that we’re doing as an injection. Peptides are intended for injection. They must be sterile. They 13:16 must be kept safe. And pharmaceutical manufacturers conduct this sterility testing on every batch. 13:22 Compoundingarmacies should conduct sterility testing particularly for high-risisk compounded 13:28 sterile preparations and research chemical suppliers may or may not conduct any testing. So injecting 13:35 non-sterile material can cause local infections, abscesses at the injection 13:41 site and or if the bacteria enters the bloodstream could potentially be 13:46 life-threatening and you could have sepsis. Now, excuse me. We saw this 13:52 happen in a compounding pharmacy uh gosh, it’s probably been 10 years ago 13:57 now, I think. um they unfortunately had a strep uh contamination in their 14:03 product and they weren’t testing it. It was a large compounding pharmacy out of Florida and they were making products 14:08 that were being injected into the joints and um these people got very very sick 14:14 and some of them died and um some of them got very very injured by this uh 14:21 complication that happened. So it’s not like this doesn’t happen. It does, but it doesn’t happen often. And that’s what 14:28 we have to know about. And so, when we’re talking with you guys about storage and stability, it’s really 14:34 important to make sure you maintain your peptides well. So, many peptides are unstable at room temperature. They 14:41 require refrigeration or freezing. We tell everyone to make sure you’re refrigerating your peptides. That way, 14:48 there’s no question about it. when it stays cold um it prevents or slows down 14:54 the process of uh bacteria growing in it. So some of these peptides actually 14:59 degrade very rapidly in the solution and they must be reconstituted immediately before use and reconstitution of the 15:07 peptides really has limited stability often just days to weeks not months. So 15:13 improper storage, temperature, um changes during shipping or prolonged 15:19 storage of a reconstituted product can lead to degradation into inactivity or 15:25 potentially even a harmful breakdown of the product itself. So if you have a product that’s been sitting in your 15:30 refrigerator for a month or two months or 3 months or 6 months, just throw it away. It’s not going to be any good. 15:37 you’re not going to actually get the peptide and the uh potency that you’re looking for anyway out of it and the 15:44 potential of you introducing an endotoxin, a bacterial endotoxin is quite high at that point. So you just 15:50 really don’t want to take the risk, excuse me. So what practitioners, what 15:56 should we do and what should patients do? Well, for any peptide therapy, we 16:03 want to source our verification. know where the peptide product comes from. Is 16:08 it an FDA approved product? Is it a 503b compounding? A research chemical 16:14 supplier? Is there a certificate of analysis? Request and review this COA. 16:20 And you want it to show purity greater than 95% but ideally greater than 98%. 16:27 You want that identity be identity to be confirmed by mass spectromedy. Uh 16:33 sterility testing should be done. Bacterial endotoxin testing should be done. Batch number matching of the 16:39 product that you received should be done. Proper storage. You want to know that this has been refrigerated or 16:46 frozen as directed once it’s been mixed. Look at the expiration dates for reconstituting your peptides. Track that 16:53 reconstitution date and discarded accordingly like we just talked about. Monitor for your adverse effects. Even 17:01 with the perfect quality control, monitoring for adverse effects is essential with questionable quality and 17:08 vigilance is really critical here. I know it’s frustrating for a lot of patients when they have to get several 17:15 bottles and they only last a week or two. right here, you guys. This is why 17:21 they only last a short period of time because once they’re mixed, they start 17:26 to degrade and they won’t be good and you won’t get the benefit from it. So, 17:31 it’s really important with these research peptides specifically, practitioners should recognize that all 17:38 recommending products without quality assurance violates the fundamental medical principle of first do no harm. 17:45 If a patient is determined to use research peptides despite counseling, providing guidance on quality 17:52 verification, requesting those COAs, using pharmaceutical grade sources when available, proper testing, this all 17:59 reduces harm, but doesn’t constitute necessarily that recommendation. Now, 18:06 that being said, today it’s very difficult to find peptides by the compoundingies because of what the FDA 18:13 has done. So most of the peptides that are available to us have been labeled 18:18 not for human consumption, not because they’re not good products, but because 18:25 of what the FDA did. And this is how these companies have been able to 18:31 continue to provide peptides to the medical community. And if you know you 18:36 have a good company, then you’re, you know, you’re still taking the risk, right? But at the end of the day, the 18:42 reason they’re doing that is to protect themselves from the FDA, from liability. Um, so just kind of know that there is 18:50 some talk in the community with um Bobby Kennedy that this is going to change and 18:55 they are going to bring peptides back to the compounding pharmacies. Now, we don’t know which ones they’re going to 19:01 bring back. Uh, will it be all of them? Will it just be some of them? What’s going to happen here? Um, is it going to 19:07 go to the pharmaceutical companies like our GLP1s did? We don’t know what that’s going to look like quite yet. Um, but it 19:14 is coming and that is positive news. So, let’s talk now about FDA approved 19:21 peptide medications. So, this is the metabolic revolution, right? GLP1 19:28 and our dual increeting agonists. This is an exciting time. GLP-1s are amazing. 19:35 Um, a lot of people are skeptical, a lot of people love them, a lot of people hate them. Whichever side of the fence 19:42 that you’re on, I understand. But I want to talk about the science of it today 19:48 and what it actually means for people. So, the story of GLP1 glucagon like 19:54 peptide one represents one of the most significant advances in metabolic 19:59 medicine in the past several decades. GLP-1 is an accretin hormone. It’s 20:05 gutder derived peptide that potentiates insulin secretion in response to food 20:11 intake. And the body naturally produces GLP-1 in the intestinal L cells, but it 20:17 rapidly degraded by the enzyme DPP4 giving it a halflife of only about 2 20:24 minutes. So this rapid breakdown made in therapeutically impractical until 20:31 research was developed and modified the analoges that resist the enzyme degradation. So for those people who 20:39 never feel full when they’re eating, never feel satisfied when they’re done, this is because their body is either not 20:46 producing enough GLP1 or it’s not getting the signal right. And this is a 20:51 leptin issue. This is an insulin issue. It’s a GLP-1 issue. It’s a complicated 20:56 issue. This is not anything that the person is doing wrong. It’s what is happening to their body. And so GLP1s 21:03 have really revolutionized this. So one particular GLP-1 that we have is 21:09 semiglutide. And this GLP-1 agonist is what changed everything in the world of 21:16 metabolic medicine. Semiglutide is marketed as ompic for type 2 diabetes 21:23 and it’s marketed as WGOI for chronic weight management. It is a modified 21:29 GLP-1 analog with 95 or sorry 94% amino acid sequence uh homology to human 21:37 GLP-1. So it means that it’s it’s just like our own GLP-1 that we make. This 21:42 modification includes specific amino acid substitutions and the addition of C18 21:50 a fatty acid chain which allows the peptide to bind to albumin. Now this 21:56 albumin binding dramatically extends the half-life to approximately one week 22:01 enabling one weekly dosing which is a major advantage over the earlier GLP-1 22:07 agonists that require daily or twice daily injections. The mechanism by which 22:13 semiglutide works is multiaceted. At the pancreatin level, it binds to GLP-1 22:20 receptors on the pancreatic beta cells enhancing glucose depending sorry 22:27 enhancing glucose dependent insulin secretion. This glucose dependency is 22:33 crucial. It means the peptide only stimulates insulin release when blood glucose is elevated. This dramatically 22:41 reduces the hypoglycemic risk compared to insulin or even uh sulfuras. 22:47 Simultaneously semiglutide suppresses glucagon secretion from pancreatic alpha 22:53 cells further improving glycemic control. This is really amazing because 23:00 over the years when we’ve used insulin, which is also a peptide by the way, you 23:05 had to dose it just right because if you didn’t, you would produce so much insulin that it would crash the blood 23:12 sugar and then somebody would have too low of a blood sugar. They’d be hypoglycemic and they’d have to eat more 23:18 sugar and then they’d have to modify the insulin again and the person would be going up and down, up and down, up and 23:24 down all day long. And that created a lot of problems for people and so this 23:30 helps to stabilize that so it is not such an intense change. Now in the GI 23:36 tract semiglutide delays the gastric emptying particularly pronounced during 23:41 the initial weeks of therapy. This slowing of the gastric emptying contributes to the sensation of being 23:48 full and early satiety that patients often describe. However, this effect 23:54 tends to attend to weight over time as the body adapts through the appetite 24:00 suppressing effects generally persist through central mechanisms. So, when we 24:05 talk about what is actually happening, we’re slowing that digestive process down. That’s why people aren’t so 24:11 hungry. It’s why they’re not eating so much. This is why people can develop constipation with these products because 24:17 it’s slowing the body’s digestive tract down. Now some people will call this 24:22 gastroparesis. Um gastroparesis is actually different. 24:28 It is when we lose control over what’s happening in the in the colon like the 24:34 nerves and things like that just stop working. I have never seen that with the GLP1s that we prescribe in micro doing. 24:42 um it’s been documented. It can happen, but again it a lot of it is dosing and a 24:48 lot of it is staying on top of your client and what’s happening and what’s going on and what you’re doing and making sure that they do have good 24:54 motility still. So a lot of these things can be mitigated if you have problems 24:59 with them. Now one of the most profound effects of semiglutide occur in the 25:05 central nervous system. GLP-1 receptors are widely distributed in the brain 25:10 particularly in the hypothalamus and the brain stem area where we are involved in 25:15 appetite regulation. So when when wilding and colleagues published their 25:20 landmark step one trial in the New England Journal of Medicine in 2021, 25:25 they demonstrated that participants receiving 2.4 4 milligrams of semiglutide weekly achieved an average 25:32 weight loss of 14.9% of their body weight over 68 weeks. Now, I want you 25:39 guys to really understand this. We’re talking roughly 15% body weight loss 25:45 over a year, longer than a year. 52 weeks is a year, right? This is 68 25:50 weeks. So, it took longer for them to lose. We’re not talking about giving 25:55 somebody a dose to lose 15% of their body mass in a month or two. That that 26:01 is not healthy for any of us. That is not what we’re talking about doing here. Now, they compared this to placebo and 26:08 the placebo was only 2.4%. So, that is a significant difference. 26:14 And even beyond the numbers, patients reported something very qualitatively different, a reduction in what’s now 26:21 called food noise. Everybody knows what food noise is. We’ve talked about this long before GLP1. It’s that craving. 26:28 It’s that part of your brain that just keeps thinking about I want to eat something. You know, that was actually 26:34 reduced and they didn’t expect to see that happen. Now, this refers to the constant mental preoccupation with food, 26:42 the intrusive thoughts about eating, the difficulty in feeling satisfied. Semi-glutide appears to appears to 26:49 modulate reward pathways in the misolyic system reducing hedonic eating and food 26:57 cravings. Now there are also great cardiovascular effects of semiglutide 27:02 that extend beyond weight loss. Uh the sustained six and select trials 27:07 demonstrated significant reductions in major adverse cardiovascular events uh 27:14 mace in high-risisk populations. The select trial published in 2023 showed 27:20 that semiglutide reduced cardiovascular death, non-fatal myioardial inffection 27:25 and non-fatal stroke by 20% in adults with overweight or obesity and 27:31 established cardiovascular disease but without diabetes. So this suggests that 27:37 mechanisms beyond glucose control and weight loss possibly including 27:42 anti-inflammatory effects, improvements in endothelial function and favorable 27:47 changes to lipid profiles. Now I will tell you the clients that I work with that are on GLP1, 27:53 they will tell you that their inflammation has been significantly reduced. We are also seeing really 28:00 amazing results in lipid profiles. um part of its weight loss, but there is a 28:06 component to this that is lowering the triglyceride levels because it’s related to sugar and how the body’s processing 28:11 it. And we’re seeing better profiles, less need for statins as a result of 28:17 that. If if you want to listen to my episode on statins, I have one on that. Uh they are not my favorite medication. 28:24 I think it’s overprescribed and overused um and not really affecting or 28:29 addressing the problem. So these things can really be helpful. There’s also some 28:34 uh ramblings going on with GLP-1s saying that they may be able to help with 28:40 addiction in the future because of where they’re finding it affecting the brain and how it affects the food noise and 28:47 the cravings that we have for food and the addiction for food. Could it potentially help with other addictions 28:53 down the road? We’ll have to wait and see on that one. So semiglutide’s FDA prescribing information also includes a 29:00 box uh boxed warning about thyroid sea cell tumors. So in rodent studies 29:06 semiglutide caused dose dependent and treatment duration dependent sea cell 29:12 tumors at clinically relevant exposures. So while it’s unknown whether or not 29:17 semiglutide causes uh thyroid cancer tumors in humans and the rodent thyroid biology 29:26 differs significantly from humans, the drug is contraindicated in patients with a personal or family history of 29:33 medillary thyroid carcinoma or in patients with multiple endocrine neopl neoplasia syndrome type two. it is 29:42 uh contraindicated for safety effects with that. Um I have seen endocrinologists okay GLP1s to be used 29:50 in patients who’ve had other forms of thyroid cancer just not the meillary 29:55 thyroid cancer. So there is possibility there. Now the most common side effects 30:00 are gastrointestinal. It’s nausea affects about 20 to 44% of patients 30:06 depending on the formulation with diarrhea, vomiting, constipation, abdominal pain, and also frequently 30:13 reported in clinical trials. I see this in my clinic, too, especially dose dependent. Um, and it happens early on 30:20 when you’re first starting the medication, but seems to settle out over time. The one that I would add to this 30:26 that I don’t think they have on here is an increase in acid reflux. We also see that quite often uh especially in people 30:33 who suffer with acid reflux to begin with. Now these effects are typically most 30:40 pronounced during the escalation and they like I said often improve over time 30:45 but more serious but less common adverse effects include acute pancreatitis. 30:51 The medication needs to be discontinued immediately if this is confirmed. You can see some diabetic retinopathy 30:57 complications in patients with pre-existing retinopathy and acute kidney injury. Um, this usually happens 31:05 secondarily to dehydration from the GI effects. There are some gallbladder disease um that can occur and people who 31:13 have a sensitive gallbladder will describe uh discomfort with that. I’ve 31:18 even seen some people who’ve had their gallbladder out on GLP1s at the higher doses complain of similar pain that they 31:25 used to have when their gallbladder was in. So, really important to just kind of monitor these symptoms and work closely 31:32 with somebody that understands them and can be on top of them quite quickly if this happens. Excuse me. From an 31:39 integrative medicine perspective, semiglutide really represents a powerful tool, but it’s not a standalone 31:46 solution. Remember, the medication addresses one aspect of the metabolic dysfunction, the signaling systems 31:53 controlling appetite and glucose homeostasis, but it doesn’t address the root cause that led to the metabolic 32:00 disease in the first place. Patients who rely solely on the medication without addressing the ultrarocessed food 32:07 consumption, the ccadian disruptions, the chronic stress, the sleep apnea, or 32:12 underlying hormonal imbalances often experience weight regain when the medication is discontinued. 32:20 The drug is also not a substitute for addressing the emotional and psychological drivers of eating 32:26 behavior, including the unresolved trauma that may manifest as emotional eating. I think this is really important 32:33 because we don’t address the trauma issue enough with clients and we need to 32:38 be looking at that. There is a huge trauma effect out there these days that is I don’t want to say leading to or 32:45 causing but it is definitely contributing to chronic illness and it’s not being talked about enough. So we 32:52 really need to be talking about this and addressing this trauma aspect. Now the next GLP that one that I want to talk 32:59 about is trespathide. This is a dual agonist. It takes center stage. It is my 33:05 favorite GLP one. Trisepatide is marketed as Mangjaro for type 2 diabetes 33:11 and Zepbound for chronic weight management and it represents the next 33:16 evolution in increantbased therapy. This is a dual agonist a 39 amino acid 33:23 synthetic peptide structurally based on the human glucose dependent insulin tropic peptide so GIP sequence but 33:31 modified to activate both the GIP receptors and the GLP1 receptors. So the 33:37 addition of the GI GIP agonism to the GLP1 agonism appears to create this 33:46 synergistic effect that goes beyond simply adding the two mechanisms together. So the GIP like GLP-1 is an 33:55 increant hormone secreted by what is called the K cells in response to nutrient intake. It enhances glucose 34:02 dependent insulin secretion but it also effects on atapost tissue metabolism 34:09 potentially improving the insulin sensitivity in fat cells and influencing 34:14 how the body stores and metabolizes fat. So some research suggests that GIP may 34:20 also have effects on energy expenditure though this remains an area of 34:26 investigation. So basically what we’re saying is this drug may actually help 34:32 people who are insulin resistant or insulin sensitive, not just somebody who 34:38 has problems with glucose control. So, this is super exciting because it opens 34:43 up the door for all of these people for decades that we’ve been trying to manage with insulin resistance and trying to 34:50 prevent diabetes and honestly most of the time have been unsuccessful 34:56 unless you can keep your diet at 50 grams of carbs or less a day, which is extremely difficult. Um, and take some 35:04 supplements that may or may not work and or take some metformin that may or may not help. this drug actually really 35:11opens that up and helps in that capacity. So there was a clinical trial 35:17 called the surmount clinical trial which demonstrated that trespathide produces 35:22 even more substantial weight loss than semiglutide. In the surerount one trial published by uh J tree I might have said 35:31 that wrong. I apologize if I slaughtered your name and colleagues in the New York England Journal of Medicine in 2022. 35:38 Participants receiving the highest dose of trespide, which is 15 milligrams, achieved an average weight loss of 20.9% 35:47 of their body weight over 72 weeks, compared to 3.1% with placebo. This 35:54 level of weight loss approaches what’s typically only seen in beriatric surgery. So, this is amazing because if 36:02 this medication works and we don’t have to do beriatric surgery, stomach stapling basically, um, oh my gosh, it’s 36:11 amazing. There are so many complications and risks that go with stomach stapling and the different procedures that they 36:17 do these days. People don’t absorb their nutrients properly. They have to do liquid nutrients. It’s very complicated. 36:24 It’s very challenging. Many of these people gain their weight back. Um, and 36:30 this procedure is not fun to go through. So, if we could change that and change 36:35 the lives of people who’ve really been struggling, it is amazing. And I will tell you that I have seen this work. I 36:42 have seen people lose 100 150 pounds on these medications over a year or two 36:50 period of time. It is definitely slower than beriatric surgery on some standpoints, but that is okay. You don’t 36:56 want that rapid weight loss. It’s not good for you. It’s not healthy for you. It doesn’t look well. You know, we want 37:03 to do this safely and effectively in the best way that we can possibly do that for you. Now, the adverse effect profile 37:10 is similar to semiglutide. It’s dominated by gastrointestinal effects. 37:15 Nausea, diarrhea, decreased appetite, vomiting, constipation. These were all commonly reported in the surmount 37:22 trials. And like semiglutide, tricepide carries a blackbox warning regarding the 37:27 thyroid sea cell tumors based on the rodent data and it shares the same contra indications in patients with a 37:34 family history of thyroid cancer and men too. So the mechanism behind why 37:40 tepatide often produces more substantial weight loss than GLP-1. The agonism 37:45 alone remains under investigation, but it may relate to the complimentary effects on the different aspects of 37:51 energy homeostasis or to GIP’s effects on atapost tissue and potentially on 37:58 central central nervous system pathways that GLP1 alone doesn’t fully address. 38:03 Now patients often report even more profound reductions in food noise with tricepide compared to GLP1 and uh sorry 38:12 GLP1 the agonists through this is anecdotal and hasn’t been regularly 38:17 quantified in quality studies. So I’ve done both uh personally and in my 38:22 practice. I really like trespide better than semiglutide. For me I had too many side effects with semiglutide. uh I had 38:30 less side effects with trespathide. I also plateaued on semiglutide which I 38:35 didn’t really care for. And with Tresepide, I haven’t plateaued and I’ve been able 38:42 to lose about 25 pounds in um a year and a half and I’ve been able to maintain 38:49 that. Um and I continued to use it because I do have a strong family history of cardiovascular disease. And 38:56 if this could help me so that I don’t follow my family lineage with cardiovascular disease, I am all for 39:03 trying to do that. I’ve watched too many of my family members suffer from this. I’ve lost my dad at a very young age. I 39:09 lost my grandfather at a young age to it. All of their brothers to this. And I don’t want to be that same person. So 39:16 that is why I chose to do that. And I think it’s really important for us to take a look at that and understand that. 39:24 Now, I know this has been a really long podcast and I don’t typically do podcasts this long. I have a whole host 39:31 of information on additional peptides. So, I’m going to break this up for you 39:36 guys and I’m going to do another episode and we’re going to pick up where we left off here with these peptides so that we 39:43 can actually start to dive into different peptides as well. So, check 39:48 out my next podcast show when we’re going to dive into the peptides that 39:54 talk about sexual wellness, immune function, and all the other cool things 39:59 that we can do with peptides. So until then, remember to like, share, and 40:04 subscribe. It really helps us get out to other people and share our information, 40:10 and join us for our next episode as we continue the talk about peptides. 40:15 Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Please note that the views and 40:21 information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its 40:28 management, or our partners. Each affiliate, sponsor, and partner is an 40:34 independent entity with its own perspectives. Today’s content is provided forformational and educational 40:40 purposes only and should not be considered specific advice, whether financial, medical, or legal. While we 40:48 strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique 40:56 circumstances. We encourage you to consult with a qualified professional to address your 41:01 individual needs. Your use of information from this broadcast is entirely at your own risk. By continuing 41:08 to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its 41:14 associates harmless from any claims or damages arising from the use of this 41:20 content. We may update this disclaimer at any time and changes will take effect 41:26 immediately upon posting or broadcast. Thank you for tuning in. We hope you 41:31 find this episode both insightful and thought-provoking. Listener discretion 41:36 is advised.The post Episode 256 – How Peptides Work, Benefits, and FDA-Approved vs Off-Label Use Explained first appeared on Let's Talk Wellness Now.

What does truly integrated care look like – and what role should dental hygienists play in it? As National Children's Dental Health Month comes to a close, host Matt Crespin sits down with two speakers from ADHA's first-ever Integrated Care Summit to explore how medical-dental integration is reshaping patient care. Nevada hygienist Jessica Woods shares real-world cases – from cardiologist referrals to coordinating airway care for her own daughter – that prove integration isn't just for public health settings. Pediatrician Dr. Connie Gundacker offers a medical perspective, revealing why most physicians receive little to no oral health training and how hygienists can bridge that gap. Together, they make a compelling case: dental hygienists are uniquely positioned to lead integration efforts, if the profession seizes the opportunity. Matt also covers ADHA award nominations, OPA legislative updates and upcoming events. Join these speakers and more at the Integrated Care Summit, May 15–17 in Broomfield, Colorado.Guests: Constance Gundacker, MD, MPH, FAAP, Section Chief of General and Community Pediatrics, Medical College of Wisconsin and Jessica L. Woods, MPH, RDH, FADHA, Chief Executive Officer, Executive RDHHost: Matt Crespin, MPH, RDH, FADHA

In fascist Italy, resistance took surprising forms. Maura Hametz shares the story of one woman who stood up to the regime–by refusing to change her name. And: Numbers of Black women legislators have increased dramatically in the last decade. Jatia Wrighten argues that the success and drive of these leaders is rooted deep in history. Later in the show: Joan of Arc wasn't the only medieval woman to lead an army. Steven Isaac brings us the queens and empresses whose military strategy drove European politics.

In today's episode, we spoke with Anne Chiang, MD, PhD, to discuss the rapidly evolving treatment landscape in small cell lung cancer (SCLC) and what this new era of innovation means for patients. Dr Chiang is an associate professor of medicine in the Section of Medical Oncology at Yale School of Medicine and associate cancer center director for clinical initiatives at Yale Cancer Center in New Haven, Connecticut.In our exclusive interview, Chiang reflected on how the field has shifted since the introduction of chemoimmunotherapy in 2018, highlighting improvements in median overall survival and the emergence of long-term responders in extensive-stage disease. Chiang also explored the growing understanding of disease heterogeneity, and the evolution of biomarker-informed strategies like under evaluation in the phase 2 S2409 PRISM trial (NCT06769126).Additionally, Chiang examined the clinical effect of DLL3-targeted therapies, including the recently approved bispecific antibody tarlatamab-dlle (Imdelltra), and how surface-targeting strategies are expanding options beyond traditional chemotherapy. Beyond efficacy, Chiang underscored the importance of individualized decision-making by assessing patient fitness beyond ECOG performance status, navigating treatment urgency in rapidly progressive disease, and balancing durability with toxicity when counseling patients on therapy.

Send a textThe wellness industry is booming, but is it actually helping people live better lives? With trillions spent on supplements, special diets, and longevity hacks, it raises a bigger question about what really matters for long-term health.Dr. Zeke Emanuel, Author, Eat Your Ice Cream joins CareTalk to discuss the wellness industrial complex, the health risks of loneliness, and why social connection, simple habits, and even ice cream may matter more than expensive longevity obsessions.

For the next few weeks, the guys will be re-airing some of their favourite episodes from our archives.This week, Asif is in France on his sabbatical. To commemorate this, the guys give each other a quiz on France. Ali starts off by quizzing Asif about French culture and cuisine. They discuss croissants, Bouillabaisse, Versailles, and French greetings. Then Asif quizzes Ali about medicine in France including the advent of teaching in hospitals, pasteurization, the guillotine (!), as well as a lightning round. The opinions expressed are those of the hosts, and do not reflect those of any other organizations. This podcast and website represents the opinions of the hosts. The content here should not be taken as medical advice. The content here is for entertainment and informational purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. Music courtesy of Wataboi and 8er41 from PixabayContact us at doctorvcomedian@gmail.comFollow us on Social media:Twitter: @doctorvcomedianInstagram: doctorvcomedianShow Notes:Revolutionary hospital medicine: https://www.sciencemuseum.org.uk/objects-and-stories/medicine/revolutionary-hospital-medicine10 Most Influential French Doctors Throughout History: https://medium.com/heritage-digest/10-most-influential-french-doctors-throughout-history-523cc4d99b15 Hosted on Acast. See acast.com/privacy for more information.

Dani Vee and Julianne Negri explore the devastating impact of youth suicide through the verse novel The Belly of a Wolf. They chat about art as medicine, the publishing industry, the importance of friendship, and the challenges of writing a verse novel. Listen now!

For more than a decade, CAR-T therapy has been the miracle of oncology, turning end-stage blood cancers into curable diseases. But the application of these engineered cell therapies is expanding to reset the immune system for patients living with lupus, stiff person syndrome and other autoimmune conditions. And with new frontiers come new rules. In this week’s episode of "The Top Line," Fierce Pharma’s Angus Liu chats with Harpreet Singh, M.D., chief medical officer at Precision for Medicine and a former director of the FDA's Division of Oncology, about a recent article by FDA officials led by CBER Director Vinay Prasad, M.D., laying out the agency’s perspective on its regulation of autoimmune CAR-T therapies. Singh discusses how the agency’s "case-by-case" approach, as indicated in the article, could be similar to—and different from—CAR-T for oncology indications. She also talks about how drug developers should follow existing development experience, as well as prepare for specific requirements for long-term patient follow-up and potential new clinical endpoints from the agency. To learn more about the topics in this episode: FDA signals tailored approach to ‘carefully shepherd’ CAR-T therapy for autoimmune diseases Kyverna gains clear view to first CAR-T approval for autoimmune disease after 'truly remarkable' SPS readout Cabaletta CAR-T wipes out B cells without preconditioning in small autoimmune trial See omnystudio.com/listener for privacy information.

Send a textIf you've been sick for months or years with no clear answers, this episode is for you.Dr. Eric Potter of Sanctuary Functional Medicine joins Michael Rubino to discuss how mold exposure impacts the immune system, brain function, hormones, fertility, and long-term health.While conventional medicine often focuses on respiratory symptoms, mold illness can present as multi-system dysfunction: brain fog, chronic fatigue, food sensitivities, depression, strange medication reactions, recurrent infections, infertility, and autoimmune issues.Dr. Potter explains:• Why mold is missed in traditional medicine• How mold suppresses immune function• Why detox takes time• Why you cannot fully heal while still in exposure• How mold affects fertility and hormone balance• The connection between mold and longevity-----------------------------------------------------------------------------------------------About Dr. PotterDr. Eric Potter graduated from Vanderbilt University School of Medicine before completing dual training in Internal Medicine and Pediatrics. Over the years, he has cared for patients of all ages and backgrounds, continually expanding his medical knowledge and clinical skills. He later dedicated hundreds of hours to earn his Institute for Functional Medicine (IFM) Certification, placing him among a select group of practitioners in the region who have completed the full program. At Sanctuary, he combines the best of conventional medicine with the best of functional medicine to deliver truly comprehensive care.Beyond his extensive training, Dr. Potter has personally experienced the challenges of today's healthcare system—both as a physician and as a family member supporting loved ones through illness. These experiences fueled his desire to create a better model of care. By stepping outside the insurance-driven system, he is able to offer longer visits, whole-person care, and unbiased recommendations with wholesale pricing on labs and supplements. Practicing functional medicine enables him to uncover root causes rather than simply manage symptoms, serving as a trusted advocate for patients seeking a healthier, more abundant life.Outside the clinic, Dr. Potter is married and a father of six, with a family story shaped by God's providence, including the blessing of adoption. He enjoys running, reading, hiking, and spending quality time with his family.

Surgical quality is a term that is often thrown around in surgical practice. We have multiple quality improvement projects, metrics and benchmarks that motivate us to do better, and of course the ever expanding patient reviews to possibly “reflect” the type of surgical care provided. But what does quality actually mean? What metrics can we use to understand the type of care being provided by ourselves, our colleagues, and the health system at large. Today, we delve into these questions to understand how quality is currently understood within surgery and how we hope it to evolve in the future. Joining BTK fellow Agnes Premkumar and ASGBI hosts Jared Wohlgemut and Gita Lingam are two fantastic guests - Dr. Mark Cheetham, joining us from the UK, has deep experience in national audits and system-level quality improvement. Dr. Cheetham is a colorectal surgeon and the National Clinical Lead for General Surgery at the Getting it Right First Time Programme in NHS England, or GIRFT. Dr. Alexander Perez is representing the US; he is a board-certified general surgeon and minimally invasive surgeon at Baylor St. Luke's Medical Center. He has worked extensively with institutional quality programs and is the current assistant Dean for patient safety, simulation, and process improvement at the Baylor College of Medicine. Resources: Institute for Healthcare Improvement: https://www.ihi.org/library/tools/quality-improvement-essentials-toolkit NSQIP: https://www.facs.org/quality-programs/data-and-registries/acs-nsqip/ Getting it right first time (UK): https://gettingitrightfirsttime.co.uk/ ***Fellowship Application Link: https://forms.gle/QSUrR2GWHDZ1MmWC6Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium:General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

Send a textAnna Rollins grew up as the kind of girl who took her faith seriously — and that's exactly why it hurt her so much. In this conversation, Anna and I dig into her memoir Famished: On Food, Sex, and Growing Up as a Good Girl, where she traces how purity culture's messages about desire, self-denial, and the body quietly fueled decades of disordered eating, compulsive exercise, and sexual pain. What strikes me most is that Anna's parents were loving, her church wasn't overtly abusive — and yet the cumulative message she absorbed was shrink yourself.  I think this conversation is going to resonate deeply with so many of you.THANKS TO OUR SPONSOR:To Heal or Harm: Scripture's Use as Poison or Medicine for Abuse Survivors by Dr. Steven Tracy. How to refute it when Bible verses are weaponized! https://amzn.to/4rSYkZuTO SUPPORT US: Join our Patreon for as little as $5 a month to support our workAnd check out our Merch, or any of our courses!Give to the Good Fruit Faith Initiative of the Bosko FoundationJoin our email list!LINKS MENTIONED: Get Anna Rollins' book FamishedFollow Anna on SubstackWatch our Love & Respect Docuseries The Portuguese version of The Great Sex RescueThe Chinese version of The Great Sex RescueThe Spanish version of The Good Girl's Guide to Great SexSupport the showJoin Sheila at Bare Marriage.com!Check out her books: The Great Sex Rescue She Deserves Better The Marriage You Want and the Study Guide The Good Girl's Guide to Great Sex and The Good Guy's Guide to Great Sex And she has an Orgasm Course and a Libido course too!Check out all her courses, FREE resources, social media, books, and so much more at Sheila's LinkTree.

This episode starts with something that makes me very angry and ends with something that makes me genuinely happy. First, we talk about what's happening in Eugene, Oregon, where a nonprofit hospital system decided not to renew a 35-year contract with its locally rooted emergency physicians and instead hand the ER over to a large corporate staffing group based thousands of miles away. Wait times went up, morale collapsed, doctors spoke up and admin responded by replacing them. If you've ever wondered how corporate medicine quietly dismantles community care, this is a textbook example. Then, to save my sanity (and yours), we pivot to something fun: medical magic. The things ophthalmologists do every day that would absolutely get us burned at the stake a few hundred years ago: instant pain relief, artificial lenses, and the quiet miracle of glasses. Takeaways: How a nonprofit hospital replaced its local ER doctors with a corporate staffing group and why it's happening all over the country. Why closing one emergency department predictably overwhelmed another and how admin blamed the wrong people. The hidden cost of replacing community physicians with rotating, nonlocal staff. The ophthalmology treatment that turns 10/10 pain into 0/10 pain in seconds and still feels like magic. Why cataract surgery and artificial lenses might be one of the greatest medical miracles of all time To Get Tickets to Wife & Death: You can visit Glaucomflecken.com/live  We want to hear YOUR stories (and medical puns)! Shoot us an email and say hi! knockknockhi@human-content.com Can't get enough of us? Shucks. You can support the show on Patreon for early episode access, exclusive bonus shows, livestream hangouts, and much more! –⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://www.patreon.com/glaucomflecken⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  Also, be sure to check out the newsletter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://glaucomflecken.com/glauc-to-me/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ If you are interested in buying a book from one of our guests, check them all out here: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/dr.glaucomflecken⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ If you want more information on models I use: Anatomy Warehouse provides for the best, crafting custom anatomical products, medical simulation kits and presentation models that create a lasting educational impact.  For more information go to Anatomy Warehouse DOT com. Link: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://anatomywarehouse.com/?aff=14⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Plus for 15% off use code: Glaucomflecken15 -- A friendly reminder from the G's and Tarsus: If you want to learn more about Demodex Blepharitis, making an appointment with your eye doctor for an eyelid exam can help you know for sure. Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.EyelidCheck.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ for more information.  Go to Cozy Earth now for a Buy One Get One Free Pajama Offer from 1/25-2/8! Yes, go to cozyearth.com they are doing a BOGO pajama promo. Just use my Code: KNOCKKNOCKBOGO Produced by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Human Content⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, producer Meagan Cantwell talks to Contributing Correspondent Warren Cornwall about his visit to Brazil, where he observed firsthand what it takes for researchers to understand why bird populations in the Amazon and beyond are shrinking. Next on the show, Raouf Belkhir, an M.D.-Ph.D. student at the University of Pittsburgh School of Medicine and Carnegie Mellon University, joins host Sarah Crespi to discuss his Science Advances paper on a newly refined way to map awake patients' brains during neurosurgery. This week's episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

How medical schools help students figure out what kind of doctor they’ll be. Looking at medical school and wondering what you’ll actually *do* with all that training? Like, you know you’ll doctor…but in what way? What will that look like for you? Luckily, most schools have something like the University of Iowa Carver College of Medicine’s distinction tracks—formal project-based programs that let med school students dig deeper into teaching, research, humanities, global health, service, or healthcare leadership while they’re grinding through anatomy and clinicals. Dave visits with M2s Tyler Pollock, Maria Schapfel, Srishti Mathur, and M1 Anna Royer for an honest, wide-ranging conversation about what these tracks actually look like from the inside. You’ll hear about Maria’s six weeks in Gabon for global health, Anna’s quilting project for humanities (yes, really), Tyler’s surgery database for teaching, and why Srishti thinks everyone should do the service track. They get into the messy reality of balancing these co-curricular activities with courses, clerkships, and shelf exams; debate whether research culture in medical school is actually helping anyone; and what things get in the way of the other things. If you’re trying to figure out how to become the kind of doctor you actually want to be—not just survive med school—this conversation will show you what’s possible beyond the curriculum. Episode credits: Producer: Tyler Pollock Co-hosts: Srishti Mathur, Maria Schapfel, Anna Royer The views and opinions expressed on this podcast belong solely to the individuals who share them. They do not represent the positions of the University of Iowa, the Carver College of Medicine, or the State of Iowa. All discussions are intended for entertainment purposes only and should not be taken as professional, legal, financial, or medical advice. Nothing said on this podcast should be used to diagnose, treat, or prevent any medical condition. Always seek qualified professional guidance for personal decisions. We Want to Hear From You: YOUR VOICE MATTERS! We welcome your feedback, listener questions, and shower thoughts. Do you agree or disagree with something we said today? Did you hear something really helpful? Can we answer a question for you? Are we delivering a podcast you want to keep listening to? Let us know at https://theshortcoat.com/tellus and we'll put your message in a future episode. Or email theshortcoats@gmail.com. We need to know more about you! https://surveys.blubrry.com/theshortcoat (email a screenshot of the confirmation screen to theshortcoats@gmail.com with your mailing address and Dave will mail you a thank you package!) The Short Coat Podcast is FeedSpot’s Top Iowa Student Podcast, and its Top Iowa Medical Podcast! Thanks for listening! We do more things on… Instagram: https://www.instagram.com/theshortcoat YouTube: https://www.youtube.com/theshortcoat You deserve to be happy and healthy. If you’re struggling with racism, harassment, hate, your mental health, or some other crisis, visit http://theshortcoat.com/help, and send additions to the resources there to theshortcoats@gmail.com. We love you.

Send me a question or story!This is the last installment in our series of DERM DRUGS. Monoclonal antibodies are becoming an important tool in veterinary dermatology — but what are they, and how do they actually work?In this episode, we break down monoclonal antibody therapy in practical terms. We explain how these targeted treatments are designed to recognize and block specific molecules in the immune system, helping reduce itch in allergic dogs without broadly suppressing immunity.We discuss commonly used products like Cytopoint which targets IL-31, a key cytokine involved in pruritus. We also introduce the announcement of an upcoming (not yet released) product called Befrena, another monoclonal antibody therapy, and what we know about this therapy today.00:00 – Intro02:07 – What is a Monoclonal Antibody03:18 – Cytopoint Basics05:35 – Potential Side-Effects06:33 – Befrena Basics08:44 – Overview09:22 – Outro

Send a textBen and Daphna conclude Journal Club with a quality improvement study from Pediatrics titled "Improving Health-Related Social Needs Screening and Support Across a Pediatric Health Care System". The hosts discuss the successful implementation of universal social determinants of health (SDOH) screening across nine pediatric divisions at Levine Children's. They highlight the impressive results—screening compliance reaching 92%—and the practical impact of connecting families to resources like FindHelp.org, which led to a 56% resolution rate in food insecurity for positive screens. Daphna makes a personal commitment to improve resource accessibility in her own unit.----Improving Health-Related Social Needs Screening and Support Across a Pediatric Health Care System. Laroia R, Minor W, Carr A, Buitrago Mogollon T, White BB, Mabus S, Stilwell L, Ahmed A, Mehta S, Obita T, Reed S, Senturias Y, Mittal S, Horstmann S, Demmer L, Dantuluri K, Chadha A, Noonan L, Courtlandt C.Pediatrics. 2026 Feb 5:e2024070035. doi: 10.1542/peds.2024-070035. Online ahead of print.PMID: 41638605Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Как приделать нос древнеиндийскому преступнику? Как исправить «заячью губу»? Откуда взять челюсть солдату, раненному в окопах Первой мировой? Именно с таких задач началась область медицины, которая сегодня ассоциируется в основном с моделями, кинозвездами и заоблачным ценником. В новом эпизоде рассказываем, как появилась пластическая хирургия: эстетическая и реконструктивная.Эксперт эпизода: Сергей Прокудин, пластический, эстетический и реконструктивный хирург, анатом и косметологСмотреть видеоверсию эпизода на YouTube: https://youtu.be/SPPfpG_JKU8

Honoring the release of All In This Together, Jack reflects on how stories awaken compassion, heal division, and call us back to meeting one another with respect.Jack's new book is out now!: All in This Together: Stories and Teachings for Loving Each Other and Our WorldToday's podcast is brought to you by BetterHelp. Give online therapy a try at betterhelp.com/heartwisdom and get on your way to being your best self.“We have the opportunity to reach out and mend the fabric of life... Action that actually undoes anxiety is making even the tiniest difference to others.” –Jack KornfieldIn this episode, Jack mindfully explores:Jack's recent trip with Trudy to India to see His Holiness the Dalai LamaWhat the Dalai Lama said about A.I. and compassionHaving a wise relationship with A.I. and technologyVaranasi and facing the reality of death at the burning ghatsStories as a medicine for the soulThe transformative story of Ram Dass, Maharajji, and the glance of mercyBeing fully worthy of loveLearning how to connect with genuineness, kindness, and respectArchetypal and universal teachingsBuddha's last mealIntention as the root of karmaOvercoming conflict with respect and good intention“Even making the tiniest difference to others begins to change the direction of your life and the circumstance of the world around you.” –Jack KornfieldThis Dharma Talk originally took place in Nov 2025 for the Spirit Rock Monday Night Dharma Talk andGuided Meditation celebrating Jack's All In This Together book release. Stay up to date with Jack's upcoming livestreams and events here.About Jack Kornfield:Jack Kornfield trained as a Buddhist monk in the monasteries of Thailand, India, and Burma, studying as a monk under the Buddhist master Ven. Ajahn Chah, as well as the Ven. Mahasi Sayadaw. He has taught meditation internationally since 1974 and is one of the key teachers to introduce Buddhist mindfulness practice to the West. Jack co-founded the Insight Meditation Society in Barre, Massachusetts, with fellow meditation teachers Sharon Salzberg and Joseph Goldstein and the Spirit Rock Center in Woodacre, California. His books have been translated into 20 languages and sold more than a million copies.Jack is currently offering a wonderful array of transformational online courses diving into crucial topics like Mindfulness Meditation Fundamentals, Walking the Eightfold Path, Opening the Heart of Forgiveness, Living Beautifully, Transforming Your Life Through Powerful Stories, and so much more. Sign up for an All Access Pass to explore Jack's entire course library. If you would like a year's worth of online meetups with Jack and fellow community, join The Year of Awakening: A Monthly Journey with Jack Kornfield. “Stories are medicine.” –Jack KornfieldStay up to date with Jack and his stream of fresh dharma offerings by visiting JackKornfield.com and signing up for his email teachings.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Time for the Married to Medicine couples trip! This episode has it all: packing, arriving, unpacking — it's almost too much to contain in one mere recap! Luckily, there's a minor spat between Toya and Heavenly to keep things amusing. To watch this recap on video, listen to our bonus episodes, and get ad free listening, go to Patreon.com/watchwhatcrappens. Find bonus episodes at patreon.com/watchwhatcrappens and follow us on Instagram @watchwhatcrappens @ronniekaram @benmandelker Hosted on Acast. See acast.com/privacy for more information.

Ozempic and other GLP-1 drugs have had a major impact in their short time on the market—currently, one in eight Americans say that they have been on GLP-1 drugs. As tens of millions of people take these medications, anecdotal evidence has emerged that they have a positive effect on alcohol abuse and drug addiction. Researchers are starting to run trials of the drugs for these purposes, and some speculate that GLP-1 drugs could even affect addiction behaviors such as gambling and online shopping. The physician and New Yorker medical correspondent Dhruv Khullar spoke with scientists and patients. “Over the course of my reporting,” he tells David Remnick, “I became more and more bullish on the idea that these are actually going to be really important molecules for the treatment of addiction.” Dhruv Khullar's “Can Ozempic Cure Addiction?” was published on February 9th. New episodes of The New Yorker Radio Hour drop every Tuesday and Friday. Join host David Remnick as he discusses the latest in politics, news, and current events in conversation with political leaders, newsmakers, innovators, New Yorker staff writers, authors, actors, and musicians.

This week on Lip Service, Angela Yee sits down with Raheem DeVaughn and Dr. Mimi from Married to Medicine for one of the most honest conversations about love, mental health, marriage, and modern relationships. Raheem opens up about losing his father, therapy as a Black man, and how grief reshaped his approach to love and self-care. He shares powerful insights behind his new project Quiet Storm Lover Vol. 1 and breaks down key takeaways from his song “20 Lessons of Love,” including why love is a verb, why actions matter more than words, and why the grass isn’t always greener. Dr. Mimi gives an inside look at marriage, accountability, and doing the personal work required to sustain real love. She talks about therapy, emotional growth, and navigating reality TV while protecting your family. She also shares her journey as a mother raising a son with autism and why representation matters. From social media boundaries and “posting your partner,” to hygiene debates, bedroom dynamics, gray areas in relationships, and when to apologize quickly — this episode blends vulnerability, humor, and real-life experience.See omnystudio.com/listener for privacy information.

Dr. Tony Wyss-Coray, PhD, is a professor of neurology at Stanford School of Medicine who is discovering factors present in young blood and in exercised blood that can improve brain, heart and other organ health. We discuss how different organs age at different rates and how to accurately measure biological aging. We also discuss the specific proteins found in blood when we are young and that are increased by things such as exercise, sunlight exposure, short-term fasting, specific foods and social connection that can significantly increase vitality, restore youthful functioning of the brain and body and potentially increase lifespan. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman ROKA: https://roka.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Tony Wyss-Coray (00:03:00) Young vs Old Animals, Age-Related Disease (00:06:35) Blood Biomarkers, Young vs Old Humans, Alzheimer's Disease (00:12:50) Sponsors: David & LMNT (00:15:28) 'Young Blood' Factors, Rejuvenation, Stem Cells (00:20:15) Blood Banking; Dracula (00:23:10) Rates of Aging in Organs, Age Gap & Disease Risk; Risk Profiles & Therapies (00:33:02) NAD Levels & Aging, NMN Supplements (00:36:44) Vitality vs Longevity; Periods of Accelerated Aging (00:43:17) Sponsors: AG1 & Roka (00:45:22) Sunlight; Youthful Blood Factors, Exercise & Brain Function, Fasting (00:51:25) Exercise, Injury & Inflammation (00:56:18) Pro-health Factors, Klotho, GDF11, Stem Cell Injection Risk (01:02:35) Platelet-Rich Plasma (PRP); Exosomes (01:05:43) Smoking, EMFs, Plastics, Long-Term Accumulation, Fresh Foods, Organic Food (01:11:28) Sponsor: Function (01:13:16) Intermittent Fasting, Long-Term Fasting, Snacking (01:19:07) Sleep; Cerebrospinal Fluid (CSF) Factors & Cognitive Function (01:24:44) Exercise Type & Longevity; Exercise Enjoyment (01:32:02) Lifestyle Factors & Alzheimer's Risk; Cognitive Exercise; Chocolate (01:37:05) Alcohol & Social Connection; US vs European Food Culture (01:40:50) Deliberate Deep Breathing; Wearables, Sunlight & Artificial Light (01:49:13) Future Projects (01:56:40) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Time for the Married to Medicine couples trip! This episode has it all: packing, arriving, unpacking — it's almost too much to contain in one mere recap! Luckily, there's a minor spat between Toya and Heavenly to keep things amusing. To watch this recap on video, listen to our bonus episodes, and get ad free listening, go to Patreon.com/watchwhatcrappens. Find bonus episodes at patreon.com/watchwhatcrappens and follow us on Instagram @watchwhatcrappens @ronniekaram @benmandelker Hosted on Acast. See acast.com/privacy for more information.