Podcasts about biomarkers

In this episode of the Dementia Researcher - Xxplored Women's Brain Health podcast, host Dr Laura Stankeviciute speaks with Professor Claudia Barth from Charite University and Dr Gillian Coughlan from Harvard Medical School to examine the midlife transition, menopause and its significance for women's brain health. Together they outline what the menopause truly involves across the early, late, and post stages, and explain how hormonal change affects brain structure, energy use, mood, and cognition. They also explore why this period may coincide with greater vulnerability to later Alzheimer's disease and discuss the role of early or surgical menopause, symptom severity, and gaps in existing research cohorts. The episode highlights the need for richer reproductive data, real time biomarker studies, and closer collaboration with digital health tools to better capture women's lived experiences. It reflects a growing wave of research and public interest aimed at improving understanding, support, and evidence based care during this important life stage. -- Takeaways ● Menopause is a long transition shaped by fluctuating hormones. ● Cognitive and mood symptoms reflect changes in brain networks. ● Earlier menopause is linked with increased later Alzheimer's risk. ● Major research cohorts lack detailed reproductive data. ● New real time studies are beginning to track symptoms and biomarkers. ● Digital tools will be key for future research. ● Better global representation is needed across studies. ● Momentum is building to close long standing gaps in women's health. -- Find bios on all our speakers, a full transcript of the show and more on our website at https://www.dementiaresearcher.nihr.ac.uk - Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://www.bsky.app/profile/dementiare…archer.bsky.social -- Download and Register with our Community App: https://www.onelink.to/dementiaresearcher -- Chapters 00:00 Introduction to Menopause and Research Focus 07:25 Understanding Menopause: Definitions and Stages 16:27 Menopause and Alzheimer's Disease: A Critical Connection 22:43 Understanding Menopause and Brain Health 25:21 Historical Blind Spots in Alzheimer's Research 26:38 The Importance of Reproductive Variables 31:46 Biomarkers and Methodologies in Women's Health Research 35:28 Industry Collaboration in Research 39:00 Personal Reflections on Women's Brain Health

Send us a textWelcome to episode 1 of our series- IBD Can Eat Me guest hosted by Stacey Collins, IBD RD. In this series, Stacey will interview other Dietitians who also specialize in IBD. This week we welcomed Venus Kalami- board-certified pediatric Dietitian Nutritionist! What if the strict diet you're told to follow does more harm than good? We sit down with pediatric dietitian Venus to unpack how nutrition in IBD can support health without sacrificing joy, culture, or family life. From Stanford Children's IBD and celiac center to medical affairs and public education, Venus brings a rare mix of clinical depth and human warmth—and she doesn't shy away from hard truths.We dig into the pressure families feel to “do everything,” the overuse of restrictive therapeutic diets, and the real risks that come with them: malnutrition, ARFID, pediatric feeding disorders, and lasting food trauma. Venus shares a clear way to tell the difference between a transient food reaction and an inflammatory flare, helping patients step off the rollercoaster of fear and over-correction. She also shows how to make care culturally inclusive with simple, powerful questions: What do you like? What do you cook? What feels doable at home? It's a move from generic handouts to plans that honor heritage foods and real life.You'll hear a vivid case study where a patient referred for low FODMAP improved dramatically without elimination—just lactase with dairy, spreading fruit across the day, and changing other patterns developed from past food trauma. We talk about involving mental health early, “asking around the ask” when supplements come up, and borrowing pediatric best practices for adults who shouldn't have to navigate IBD alone. The theme running through it all: patients deserve permission to dream beyond survival. Biomarkers matter, but so do birthdays, travel, and the comfort foods that make you feel at home.If this conversation resonates, follow the show, share it with someone who needs a gentler path, and leave a review to help more people find evidence-based, humane IBD care. Your feedback shapes future episodes—what question should we tackle next?Nutrition Pearls podcast with VenusVenus on XSolid Starts app"Offering Nutritional Therapies to Patients with IBD: Even If You're Not An Expert"- Video from Nutritional Therapy for IBDLet's get social!!Follow us on Instagram!Follow us on Facebook!Follow us on Twitter!

Send us a textHow far can AI go in helping us diagnose disease—without losing the human judgment patients rely on?In this episode, I break down four studies shaping the future of digital pathology, oncology, and neurology. From spatial biology updates at SITC to voice-based Alzheimer's detection, deep learning for sarcoma prognosis, and new guidelines for safe AI deployment, this week's digest highlights where AI is making a real impact—and where caution still matters.Episode Highlights1️⃣ SITC Trends & Spatial Biology (00:00 → 07:40)I share key updates from SITC 2025, including the growing role of multiplex immunofluorescence (mIF) and the need for integrated staining-to-scanning workflows. I also preview new educational content and upcoming podcast guests in global AI research.2️⃣ Digital Neuropathology & Alzheimer's (07:40 → 13:01)A major review confirms that digital neuropathology is now robust enough for large-scale Alzheimer's studies—opening doors for computational tools to link histology with cognition.3️⃣ Patient Safety in AI (13:01 → 19:56)An Italian review underscores the foundations of trustworthy AI: dataset quality, transparency, oversight, and continuous validation. I discuss why “patient-centered AI” must remain our standard.4️⃣ Voice Biomarkers for Cognitive Decline (19:56 → 26:43)AI models analyzing short speech recordings are showing high accuracy for early Alzheimer's detection. This could make future screening simple, noninvasive, and more accessible.5️⃣ Deep Learning for Sarcoma Prognosis (34:06 → 35:59)A multi-instance CNN outperforms FNCLCC grading by identifying prognostic patterns in tumor center and periphery regions, offering new insights into soft-tissue sarcoma biology.TakeawaysmIF is maturing quickly but needs standardized, end-to-end workflows.Digital neuropathology is ready for broader Alzheimer's research.Safe AI requires multidisciplinary collaboration and rigorous validation.Voice biomarkers may become powerful tools for early cognitive assessment.Deep learning can refine prognosis and reveal hidden tumor patterns.ResourcesHamamatsu (MoxiePlex) • Biocare Medical (ONCORE Pro X) • SITC Programs • Recent publications on AI biomarkers and computational pathology.Thanks for listening—and for being part of this growing digital pathology community.Support the showGet the "Digital Pathology 101" FREE E-book and join us!

JACC's November 25, 2025 issue kicks off Thanksgiving week with JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, reflecting on his editor's page and the day he became a doctor (0:12).  For original research articles, he discusses a study on colchicine & clonal hematopoiesis, an exploratory study of the LoDoCo2 trial (1:10), and a paired editorial comment with more perspectives and a reminder of the upcoming COLCOT trial (4:33). Next, a study on Lp(a) and IL-6 (4:54) and an editorial (6:12), 30-year CVD risk percentiles based on the PREVENT equations (6:30), and an accompanying editorial from JACC Deputy Editor Erica Spatz, MD, on next-generation strategies to encourage healthier behaviors (7:35).  Other studies and editorials include a fascinating look at alcohol and blood pressure (8:04) and reinforcing the WHO public health guidance (10:05); remnant cholesterol in young adults (10:38) and implications for cholesterol guidelines (12:36). We also include four brief reports on RSV vaccine (13:11), long Covid (13:43), Lp(a) levels (14:06), the predictive power of polygenic risk scores (14:58), a viewpoint on US veterans (15:36), and our regular Amara Yad image (15:53), which we're delighted to be able to continue to promote with JACC: Clinical Electrophysiology Editor-in-Chief Kalyanam Shivkumar, MD.  

Today, I'm joined by the inspiring Dr. Darshan Shah, a board-certified surgeon who made the bold leap from the operating room to the forefront of longevity and functional medicine. In our conversation, Dr. Shah opens up about his own journey through burnout, chronic illness, and autoimmune disease, and shares how simple, consistent lifestyle changes became the real medicine that transformed his health. His experience revealed firsthand just how powerful habits like movement, proper nutrition, and sleep can be—often succeeding where surgery and prescriptions fell short.   Episode Timestamps: Intro and offers ... 00:00:00 Dr. Darshan Shah's journey from surgery to lifestyle medicine ... 00:04:37 Simple actions: nutrition, movement, habit formation ... 00:08:41 Challenges of doctors embracing lifestyle changes ... 00:11:06 Building a parallel system: prevention and chronic care ... 00:14:32 Empowering patients: tech, wearables, and AI ... 00:18:27 Therapeutic plasma exchange (TPE): mechanism and safety ... 00:27:47 Essential biomarker and at-home tests ... 00:48:19 Continuous glucose monitors and real-time health feedback ... 00:52:33 Next Health model: prevention, functional, lifestyle, longevity ... 00:43:08 Longevity circuit: cellular gym approach ... 00:59:37 Liquid biopsy and early cancer detection ... 01:02:08 Advice for health, self-care, and lifelong vitality ... 01:09:31 Where to learn more and clinic expansion ... 01:10:26   Our Amazing Sponsors: Manukora honey - From remote forests in New Zealand, where bees collect nectar from the native Manuka tea tree. That nectar is naturally rich in antibacterial compounds like MGO, plus antioxidants and prebiotics that support immunity and gut health. Visit manukora.com/NAT to save up to 31% plus $25 worth of free gifts with the Starter Kit - you'll get an MGO 850+ Manuka Honey jar, 5 travel sticks, a wooden spoon, and a guidebook. *Look out for their Black Friday/Cyber Monday promotion from 11/17/25 - 12/02/25..   Qualia NAD+ - A groundbreaking, doctor-formulated vegan formula that boosts your NAD levels by up to 67% for enhanced cellular energy, DNA repair, and detox support. Go to qualialife.com/NATHALIE  and use promo code NATHALIE to get 15% off—and try it risk-free with their 100-day money-back guarantee.   Probiotic Breakthrough by Bioptimizers - uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at bioptimizers.com/bionat and use code BIONAT for 15% off any order. Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/APF865. CME/EBAC/AAPA/IPCE credit will be available until November 21, 2026.Nuclear Medicine for Alzheimer's Disease in the Hot Seat: Case Conference on Advancing Early Diagnosis With PET Imaging and Biomarkers In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/APF865. CME/EBAC/AAPA/IPCE credit will be available until November 21, 2026.Nuclear Medicine for Alzheimer's Disease in the Hot Seat: Case Conference on Advancing Early Diagnosis With PET Imaging and Biomarkers In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

HOUR 1 Hour 1 of Rush to Reason ignites Health & Wellness Wednesday with Dr. Scott Faulkner, owner of Castle Rock Regenerative Healthcare (https://castlerockregenerativehealth.com), stepping in for John Rush. He's joined by biohacker and high-performance health strategist Jeremy Sova, whose dramatic personal transformation has placed him just one degree from today's top longevity pioneers. But can the cutting edge of biohacking really help you reverse aging, sharpen performance, and even conquer brutal long-haul jet lag? Together, Dr. Scott and Jeremy unpack the radical experiments of tech mogul Brian Johnson—the Braintree/Venmo creator turned full-time anti-aging test case. What happens when someone pours millions into biomarker testing, optimal equipment, and scientific rigor? And more importantly: What lessons can normal people take from the world's most advanced N=1 experiment? Listeners get a fast-paced look at VO₂ max, circadian rhythm, biological age, healthspan vs. lifespan, and Jeremy's evidence-based jet-lag protocol used by world travelers and peak performers. Then Dr. Scott drops a major reveal: a new generation of sublingual peptides—no injections, no needles—thin dissolvable strips that bypass the liver for dramatic absorption and game-changing results. HOUR 2 Hour 2 of https://RushToReason.com dives even deeper into the world of high-performance health as Dr. Scott continues the conversation with biohacking expert Jeremy Sova. But this hour isn't just about supplements or trends—it's about asking the question too many people avoid: How well do you actually know what's happening inside your body? From the dangers of taking the wrong supplements to the power of 110-plus biomarker panels, Dr. Scott and Jeremy reveal why fundamental transformation starts with data—not guesswork. What hidden issues could your basic labs be missing? And how much faster could you reclaim energy, metabolism, and longevity with targeted optimization instead of chasing fads? A caller sparks a fascinating discussion on sunlight, circadian rhythm, vitamin D, seasonal affective disorder, and the rising field of red-light therapy. Could light itself be one of the most underrated health tools of our generation? Then Dr. Scott unveils major news: Castle Rock Regenerative Healthcare is expanding—bringing in a new -170°F electric cryotherapy chamber, DaVinci EWOT systems, and CAROL REHIT bikes designed to supercharge VO₂ max, muscle mass, and healthy aging. HOUR 3 Hour 3 of Rush to Reason explodes into one of the most forward-thinking conversations in modern longevity as Dr. Scott, continues with biohacker Jeremy Sova to unveil the next wave of regenerative medicine. The hour opens with a deep dive into plasmapheresis—a therapy powerful enough to lower inflammatory cytokines, reset the immune system, reverse biological age, and even remove PFAS “forever chemicals.” But why are only 20 people being offered a one-time, dramatically discounted launch? And what does this treatment mean for young women preparing for pregnancy… or biohackers chasing optimal health? From there, the conversation sharpens: How dangerous are the microplastics and toxins we're unknowingly passing on to the next generation? Can Quest biomarker panels reveal hidden immune threats before symptoms appear? And what happens when you finally have a treatment that can remove those chemicals instead of just worrying about them? Then Dr. Scott shifts gears—and shocks listeners—with his personal experience using next-generation stem cell blends for hair regrowth and joint repair. Jeremy adds his own proof-of-concept story with the HOCATT ozone sauna, boosting immunity so powerfully that even a 103° fever couldn't take him down. Tune in to find out how different your future might look if you started on a new health journey now?

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/APF865. CME/EBAC/AAPA/IPCE credit will be available until November 21, 2026.Nuclear Medicine for Alzheimer's Disease in the Hot Seat: Case Conference on Advancing Early Diagnosis With PET Imaging and Biomarkers In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/APF865. CME/EBAC/AAPA/IPCE credit will be available until November 21, 2026.Nuclear Medicine for Alzheimer's Disease in the Hot Seat: Case Conference on Advancing Early Diagnosis With PET Imaging and Biomarkers In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/APF865. CME/EBAC/AAPA/IPCE credit will be available until November 21, 2026.Nuclear Medicine for Alzheimer's Disease in the Hot Seat: Case Conference on Advancing Early Diagnosis With PET Imaging and Biomarkers In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/APF865. CME/EBAC/AAPA/IPCE credit will be available until November 21, 2026.Nuclear Medicine for Alzheimer's Disease in the Hot Seat: Case Conference on Advancing Early Diagnosis With PET Imaging and Biomarkers In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

As new genetic and AI-powered tools emerge for bladder cancer screening, are we getting closer to reducing the need for invasive cystoscopies? In part five of the 2025 BackTable NMIBC Creator Weekend™ series, host Dr. Vignesh Packiam engages in an insightful discussion with Dr. Sarah Psutka from the University of Washington and Dr. Katie Murray from NYU about the complexities and potential benefits of using biomarkers in non-muscle invasive bladder cancer (NMIBC). --- This podcast is supported by: Ferring Pharmaceuticals https://www.ferring.com/home-classic/people-and-families/uro-uro-oncology/bladder-cancer/ --- SYNPOSIS The conversation covers the current challenges of interpreting positive biomarkers without clinical correlates, the gold standard of biopsies, and the potential of various biomarkers such as urine cytology, FISH, and newer genomic tests like the Decipher Bladder Genomic Classifier. They also touch upon the role of AI in pathology, the cost implications of biomarkers, and how these tools might influence future clinical practices and patient decisions. The episode emphasizes the need for precision medicine, careful patient counseling, and the impact of false positives and negatives on both patients and healthcare providers. --- TIMESTAMPS 00:00 - Introduction05:25 - Challenges with Current Biomarkers08:10 - New Biomarkers and Genomic Classifiers21:10 - AI and Pathology in Bladder Cancer35:13 - Screening and Future Directions41:20 - Challenges and Future Directions in Bladder Cancer Surveillance57:51 - Conclusion --- RESOURCES DaBlaCa-15 Trialhttps://pubmed.ncbi.nlm.nih.gov/40280776/ Sam Chang CHAI Studyhttps://pubmed.ncbi.nlm.nih.gov/40514253/

What if entrepreneurship could fundamentally change how we experience aging—making it more joyful, independent, and connected? On this special “ICYMI Aging” episode of The Angel Next Door Podcast, host Marcia Dawood brings together highlights from interviews with three pioneering guests who are reinventing what it means to grow older.You'll hear a recap of the insights from Dr. Kerry Burnight, who blends cutting-edge research and family wisdom to prevent elder abuse and loneliness; Hunter Ziesing, who uses tech and AI to personalize healthcare and empower people to own their wellbeing; and Bruce Simpson, an investor building the largest age tech marketplace to help seniors stay independent and financially secure.If you're curious about the future of aging, entrepreneurship, and technology's role in all of it, this episode will give you the highlights. When it comes to aging, having proactive strategies, community, and smart innovations can help us all thrive—at any age. Sign up for Marcia's newsletter to receive tips and the latest on Angel Investing!Website: www.marciadawood.comDo Good While Doing WellLearn more about the documentary Show Her the Money: www.showherthemoneymovie.comAnd don't forget to follow us wherever you are!Apple Podcasts: https://pod.link/1586445642.appleSpotify: https://pod.link/1586445642.spotifyLinkedIn: https://www.linkedin.com/company/angel-next-door-podcast/Instagram: https://www.instagram.com/theangelnextdoorpodcast/Pinterest: https://www.pinterest.com/theangelnextdoorpodcast/TikTok: https://www.tiktok.com/@marciadawood

Ruben Y Luo, Priscilla S W Yeung, Morgan W Mann, Lichao Zhang, Yifei K Yang, Andrew N Hoofnagle, Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1111–1124, https://doi.org/10.1093/clinchem/hvaf094

In this episode, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, dives deep into estrone, one of the three key estrogens, and explains why understanding it is crucial for women's health. Learn about: The differences between estradiol, estriol, and estrone How estrone levels shift during perimenopause and menopause Why oral estrogen can dramatically increase estrone The impact of lifestyle factors like diet, body fat, stress, alcohol, and sedentary behavior on estrogen balance Practical tips to support healthy estrogen metabolism naturally Dr. McCarthy breaks down complex biochemistry in a clear, actionable way so you can take charge of your hormonal health.   Citations: 1. Bulun, Serdar E., et al. “Aromatase and Estrogen Biosynthesis in Adipose Tissue.” Endocrine Reviews, vol. 23, no. 3, 2002, pp. 305–342. 2. Labrie, Fernand, et al. “Importance of the Intracrinology of Estrogen Synthesis in Peripheral Tissues in Postmenopausal Women.” Journal of Steroid Biochemistry and Molecular Biology, vol. 118, nos. 4–5, 2010, pp. 273–279. 3. Sasano, Hironobu, and Toshihiko Harada. “Differential Expression of Aromatase and 17β-Hydroxysteroid Dehydrogenase Isoenzymes in Human Tissues.” Journal of Steroid Biochemistry and Molecular Biology, vol. 86, no. 3–5, 2003, pp. 327–333. 4. Yager, James D., and Nancy E. Davidson. “Estrogen Carcinogenesis in Breast Cancer.” New England Journal of Medicine, vol. 354, no. 3, 2006, pp. 270–282. 5. Cavalieri, Ercole L., and Eleanor G. Rogan. “Depurinating Estrogen-DNA Adducts, Mechanisms of Formation, and Prevention.” Clinical Cancer Research, vol. 16, no. 3, 2010, pp. 596–602. 6. Suba, Zsuzsanna. “Circulating Estrogens and Estrogen Metabolism in Obese Women.” Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 11, 2013, pp. 4336–4344. 7. Simpson, Evan R., and Konstanze C. Pike. “Aromatase Expression in Adipose Tissue: Relationship to Obesity and Insulin Resistance.” Endocrinology, vol. 156, no. 9, 2015, pp. 3422–3435. 8. Key, Timothy J., et al. “Circulating Sex Hormones and Breast Cancer Risk Factors in Postmenopausal Women: Reanalysis of 13 Studies.” British Journal of Cancer, vol. 105, no. 5, 2011, pp. 709–722. 9. Stanczyk, Frank Z., et al. “Oral, Transdermal and Injectable Hormone Therapy: Pharmacokinetics and Effects on Estrone/Estradiol Ratios.” Menopause, vol. 24, no. 9, 2017, pp. 1080–1090. 10. Santen, Richard J., et al. “Estrogen Bioidentical Hormone Therapy: Route of Administration and Risk.” Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 7, 2020, pp. 2062–2074. 11. Zeleniuch-Jacquotte, Anne, et al. “Postmenopausal Levels of Estrone, Estradiol, and Estrone Sulfate and Breast Cancer Risk.” Cancer Epidemiology, Biomarkers & Prevention, vol. 23, no. 8, 2014, pp. 1531–1539. 12. Dall, Gabriella V., and Christine L. Clarke. “Local Estrogen Biosynthesis and Signaling in Breast Cancer Progression.” Steroids, vol. 78, no. 7, 2013, pp. 639–646. 13. Heald, Anthony H., et al. “Relationships Between Serum Estrone, Insulin Resistance, and Adiposity in Postmenopausal Women.” Clinical Endocrinology, vol. 67, no. 3, 2007, pp. 340–345. 14. Kuiper, George G. J. M., et al. “Estrogen Receptor β Selectivity of Estriol and Implications for Tissue-Specific Effects.” PNAS, vol. 94, no. 17, 1997, pp. 9105–9110. 15. Michnovicz, Joseph J., et al. “Dietary Indoles and Estrogen Metabolism: Effects of Cruciferous Vegetable Intake.” Journal of Nutrition, vol. 134, no. 12, 2004, pp. 3479S–   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

Today, in association with Proteomics International, we're hearing about a new era in medicine where we can tell people not what diseases they've got, but what ones they will have in ten years' time, giving them a chance to turn things around... Like this podcast? Please help us by supporting the Naked Scientists

In this episode, Elizabeth sits down with Nate Graville, founder of Geviti, to talk about the new era of health—where prevention, biomarkers, and AI are changing the game. Nate shares how losing his father to preventable cancer inspired him to build a proactive healthcare model that helps people catch disease before it starts.He breaks down what traditional medicine gets wrong, how Big Pharma shapes medical education, and how AI and peptides are helping people take control of their health. This conversation is a wake-up call about how we approach wellness, and what's possible when we stop waiting for illness to take action.Connect with Nate Graville:Instagram: @nategravilleWebsite: www.gogeviti.com/thewellnessprocessUse code WELLNESS for 20% off your first purchase.Watch the episode on YouTube:@thewellnessprocessFollow The Wellness Process:Instagram: @thewellnessprocesspodTikTok: @thewellnessprocesspodProduced by Dear MediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In the second part of this two-part series, Dr. Kaitlyn Palmer explains how these biomarkers change our approach to diagnosing multiple sclerosis. Show reference: Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Montalban, Xavier, et al. The Lancet Neurology, Volume 24, Issue 10, 850 - 865

Sara Hägg, PhD is an associate professor at Karolinska Institutet, where she leads the Molecular Epidemiology of Aging Group. Her work focuses on human biomarkers of aging - especially biological age “clocks” built from epigenetic, proteomic, and metabolomic data - and on turning Nordic registry resources into clinically useful aging measures.In this episode:* What biological/epigenetic age clocks actually measure (and what they don't)* Accuracy, error bars, and why clocks aren't clinic-ready yet* Epigenetic vs. proteomic vs. metabolomic clocks - strengths and trade-offs* Organ-specific clocks (liver, ovary, kidney) and what they reveal* Why uncertainty spikes at life transitions; menopause as a natural “stress test”* PC (principal-component) clocks and noise reduction* Nordic registry & Swedish Twin Registry advantages; UK Biobank use* Direct-to-consumer tests: interpreting results and common pitfalls* AI's role in building/validating clocks and handling uncertainty* What would move the field fastest (data, standards, trials) and where Sweden standsShow notes for this episode will be available after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.comLEVITY is co-hosted by Patrick Linden, philosopher and author, and Peter Ottsjö, journalist and author.CHAPTERS00:00 Introduction03:27 Why Sweden lags behind in longevity science08:04 Nordic registry & Swedish twin registry advantages; UK Biobank use10:05 What is biological age?16:33 The rise of epigenetic clocks24:22 The importance of aging clocks32:04 Beyond methylation: proteomic and metabolomic clocks35:12 Organ clocks39:37 Do aging clocks generalize?54:37 The cost of aging clocks01:03:18 Uncertainty and AI01:17:10 Solving aging - where do we stand?01:28:10 Book recommendations Hosted on Acast. See acast.com/privacy for more information.

In part one of this two-part series, Dr. Kaitlyn Palmer discusses two new MRI biomarkers to increase diagnostic specificity for multiple sclerosis.  Show reference:  Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Montalban, Xavier, et al. The Lancet Neurology, Volume 24, Issue 10, 850 - 865

Dr. Kelly Makielski and Dr. Jaime Modiano from the University of Minnesota join us on OsteoBites to discuss comparative extracellular vesicle (EV) biomarkers for osteosarcoma risk and prognosis.They are investigating extracellular vesicle (EV) transcriptomic profiles as minimally invasive biomarkers in canine and pediatric osteosarcoma in two ongoing studies. In the Canine Osteosarcoma Early Detection (COED) study, they are sequencing EV RNA from otherwise healthy dogs in breeds at elevated risk of osteosarcoma to identify gene signatures for the early detection and risk assessment of osteosarcoma. In parallel, they are conducting the KIDsCAN study, where we are sequencing EVs from pediatric osteosarcoma patients to identify prognostic signatures that could ultimately guide treatment intensity, aiming to minimize long-term therapy-associated morbidity without negatively impacting survival. Preliminary results from COED will be shared, along with how their comparative approach is helping to guide the KIDsCAN study.Kelly M. Makielski, DVM, DACVIM (SAIM) is an Assistant Professor of Small Animal Internal Medicine at the University of Minnesota College of Veterinary Medicine and Masonic Cancer Center. Her research focuses on extracellular vesicle (EV) biology and comparative oncology, using naturally occurring cancers in dogs to inform human cancer biology and treatment. She is the recipient of an NIH K01 investigating EV–based biomarkers for osteosarcoma prognosis in pediatric osteosarcoma, to guide personalized therapy and reduce treatment-related morbidity.Dr. Jaime Modiano holds the Alvin and June Perlman Endowed Chair of Animal Oncology and is director of the Animal Cancer Care and Research Program of the College of Veterinary Medicine and the Masonic Cancer Center, University of Minnesota. He completed his training through the Veterinary Medical Scientist Training Program (VMD, PhD) at the University of Pennsylvania, and he followed it with a residency in Clinical Pathology at Colorado State University and a post-doctoral fellowship at the National Jewish Center for Immunology and Respiratory Medicine. Before joining the University of Minnesota, he served on the faculties of Texas A&M University and the University of Colorado Health Sciences Center. Dr. Modiano has also worked in the private sector, as founder of several start-up companies, and as Director of Cancer Immunology and Immunotherapy for the Donald Monk Cancer Research Foundation. Through his research, Dr. Modiano seeks to understand how and why cancer happens and to develop strategies for improving the health and well-being of companion animals and humans alike.

Send us a textIn this episode of At the Bench, Betsy Crouch and David McCulley engage in a thought-provoking conversation with Dr. Eleanor Molloy, a neonatologist and physician scientist. They explore Eleanor's journey in neonatology, the importance of inflammation in neonatal health, and the challenges and rewards of conducting research in this field. The discussion also highlights the significance of collaboration, both within research teams and with parents, to enhance clinical practice and improve outcomes for neonates. Eleanor shares insights on the role of biomarkers, the impact of sex differences in research, and the necessity of international collaboration in pediatric research. The episode concludes with reflections on the balance between clinical work and research, the importance of community in academia, and the need for a rallying call to inspire the next generation of clinician scientists.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Ever heard of a medical procedure that's been called an “oil change for your blood”?In this episode, I sit down with Dr. Brad Younggren to explore Therapeutic Plasma Exchange (TPE), a cutting-edge intervention that just might help extend healthspan, reduce biological age, and even clear hidden toxins like microplastics.We discuss the fascinating science behind TPE, from the famous parabiosis experiments in rodents to human trial data from Circulate and the Buck Institute. Dr. Younggren walks us through what really happens during TPE, which biomarkers shift the most, and who might benefit the most.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Chapters:00:00:00 — “Oil change for blood”00:01:05 — How TPE works (centrifuge)00:05:10 — Foundational science/parabiosis00:12:07 — Trial design & sham control00:22:39 — Headline result: “-2.6 years”00:34:01 — Compartment theory explained00:46:31 — Moving TPE to clinics00:48:03 — Long-COVID anecdote00:54:34 — Microplastics discussion01:06:38 — Cost & access overviewDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

- Non-Small Cell Lung Cancer (NSCLC) Treatment - Current Standard of Care - The Role of Chemotherapy, Radiation Oncology & Targeted Cancer Therapies - New Treatment Approaches - The Role of Biomarkers & Precision Medicine in Informing Treatment Choices - How Clinical Trials Contribute to Treatment Options - New Ways to Manage Treatment Side Effects, Symptoms, Discomfort & Pain - Communicating with Your Health Care Team About Quality-of-Life Concerns - Nutrition & Hydration Concerns & Tips - Key Questions to Ask When Communicating with Your Health Care Team - The Increasing Role of Telehealth/Telemedicine Appointments - Guidelines to Prepare for Telehealth/Telemedicine Appointments, Including Technology, Prepared List of Questions & Discussion of OpenNotes - The Important Role of Lifestyle & Movement - Questions for Our Panel of Experts

- Non-Small Cell Lung Cancer (NSCLC) Treatment - Current Standard of Care - The Role of Chemotherapy, Radiation Oncology & Targeted Cancer Therapies - New Treatment Approaches - The Role of Biomarkers & Precision Medicine in Informing Treatment Choices - How Clinical Trials Contribute to Treatment Options - New Ways to Manage Treatment Side Effects, Symptoms, Discomfort & Pain - Communicating with Your Health Care Team About Quality-of-Life Concerns - Nutrition & Hydration Concerns & Tips - Key Questions to Ask When Communicating with Your Health Care Team - The Increasing Role of Telehealth/Telemedicine Appointments - Guidelines to Prepare for Telehealth/Telemedicine Appointments, Including Technology, Prepared List of Questions & Discussion of OpenNotes - The Important Role of Lifestyle & Movement - Questions for Our Panel of Experts

In this podcast, Director of GLP bioanalysis Lan Li reviews immunoassays versus mass spectrometry-based methods as tools for protein biomarker quantitation. Focusing specifically on mass spectrometry approaches, Lan explores various methodologies, such as top-down, middle-down and bottom-up, as well as the sample preparation procedures required. Lan concludes by reviewing the current challenges impacting protein biomarker quantification and how QPS Holdings, LLC is developing solutions to overcome them.

How are leading urologic oncologists using advanced biomarkers and artificial intelligence to refine the diagnosis and management of non-muscle invasive bladder cancer (NMIBC)? In the opening episode of our 2025 NMIBC Creator Weekend™ series, host Dr. Bogdana Schmidt engages in an insightful, in-studio discussion with Dr. Anne Schuckman and Dr. Piyush Agarwal about contemporary strategies and challenges in the diagnosis of non-muscle invasive bladder cancer.---This podcast is supported by an educational grant from Ferring Pharmaceuticals.---SYNPOSISThe doctors emphasize the importance of having an experienced cytopathologist and discuss the use of different biomarkers and imaging modalities in bladder cancer diagnosis. The conversation delves into risk stratification, patient management strategies, and the evolving role of technology and artificial intelligence in enhancing diagnostic accuracy. The experts also share their perspectives on future advancements and their potential impact on clinical practice.---TIMESTAMPS00:00 - Introduction04:05 - Surveillance and Follow-Up Strategies10:10 - Biomarkers in Bladder Cancer18:02 - Blue Light Cystoscopy and Patient Comfort30:56 - Risk Assessment and Counseling42:56 - Future of Bladder Cancer Diagnostics47:00 - Concluding Thoughts---RESOURCESCxBladder Studyhttps://www.sciencedirect.com/science/article/pii/S1078143923000091Lars Dyrsakjot Study on Tumor Markershttps://pmc.ncbi.nlm.nih.gov/articles/PMC7690647/The Bridge Trialhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10515442/

Alzheimer's and dementia aren't just a matter of age or genetics. Increasing evidence shows that metabolic health—particularly insulin resistance—plays a key role in cognitive decline.In this episode of A Whole New Level, neurologist and bestselling author Dr. David Perlmutter joins Mike Haney to explore the links between brain health and metabolism. They discuss the role of insulin resistance and inflammation in Alzheimer's disease, the biomarkers that can reveal risk decades before symptoms, and how lifestyle interventions can dramatically change your trajectory.Topics include:Key biomarkers for assessing brain health: fasting insulin, A1C, homocysteineWhy targeting inflammation may matter more than targeting amyloid plaquesThe promise and limitations of GLP-1 medications for dementia and Parkinson'sPractical steps you can take now to protect long-term cognitive functionSign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl

HR2 Dr. Scott: Forget Quick Fixes—Know Your Biomarkers. Blueprint to Lasting Energy & Weight Loss 10-8-25 by John Rush

In this episode of the WHOOP Podcast, Founder and CEO, Will Ahmed, and Chief Product Officer, Ed Baker introduce WHOOP Advanced Labs — an all new feature that integrates 65 blood biomarkers with WHOOP data to deliver personalized coaching, clinician-reviewed reports, and actionable health insights. Learn exclusive insight about how WHOOP Advanced Labs empowers members to take control of their health, encourage lifestyle changes, and move closer to our mission at WHOOP to add 1 billion healthy years to people's lives.Sign up for WHOOP Advanced Labs(00:00) Introduction to WHOOP Advanced Labs(02:51) Biomarkers, Bloodwork, & WHOOP Data(04:03) Uploading Past Bloodwork: How It Works(07:54) WHOOP Advanced Labs Subscription with Quest Diagnostics(12:03) Analyzing the 65 Key Biomarkers with WHOOP(13:34) Healthspan: Applying Advanced Labs Data to Weekly Habits(14:36) Bloodwork and Biomarkers as a Baseline For Sleep, Recovery, and Health(15:43) Data Made Simple(17:13) The Bigger Picture: The Future of WHOOP Advanced Labs(18:45) Privacy Assurance & Protecting User Data(19:30) Impact of Advanced Labs on Daily HabitsThe first 100 members to tap this link will unlock early access to WHOOP Advanced Labs.**Open the link on the same device as your WHOOP app.Support the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Sign up for WHOOP Advanced Labs Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn

2025 ACC Scientific Statement on Inflammation & Cardiovascular Disease

You've seen the headlines about new blood tests and treatments for Alzheimer's, Parkinson's, and ALS, but what's the science behind those breakthroughs? In this episode, HudsonAlpha scientists Ben Henderson, PhD, and Bri Rogers, PhD, break down the role of biomarkers and genetics in early detection and treatments of neurodegenerative diseases. Discover how research being conducted today is creating real hope for tomorrow.To go behind the scenes and learn more about this episode, visit “Beyond the Headlines: How Biomarkers and Genetics are Changing Neurodegenerative Disease Research.” If you prefer to watch your podcasts, head over to our Youtube channel. Thanks for listening! We're now on YouTube- follow us here. To receive episode updates and bonus material, subscribe to our mailing list here.

In this episode of the Let's Talk Brain Health Podcast, we welcome Dr. Kellyann Niotis, MD, the world's first fellowship-trained preventive neurologist, who shares her insights on early detection and risk reduction for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Lewy body dementia. Dr. Niotis discusses the emerging field of preventive neurology, the role of blood biomarkers and genetic testing, and the importance of lifestyle choices in maintaining brain health. She also highlights the impact of cholesterol management, sleep studies, and the significance of personalized care approaches. Join us as we dive into a comprehensive discussion about the future of brain health and the proactive steps we can take today for healthier brains tomorrow.00:00 Introduction to Dr. Kellyann Niotis, MD02:47 What is Preventive Neurology?06:08 The Role of Biomarkers in Early Detection13:52 Lifestyle Modifications and Brain Health17:12 Cholesterol and Brain Health24:15 The Impact of Statins on Cognition26:05 Underutilized Tools in Brain Health30:11 Rapid Fire Questions and Final ThoughtsResourcesConnect with Kellyann on Instagram @drkellyannniotis Visit her website ​​and learn more about her new clinic on their websiteResearchLearn more about the research-informed brain health risks mentioned in this episode from the “Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission” ReportRead more about Dr. Lisa Misconi's research on how estrogen receptors are unregulated in perimenopause in this research article 

Rheum to Breathe Rx Update ILD Treatment and Guidelines Part 3: ILD Assessment and Management including: Biomarkers in ILD (Dr. Elena Joerns), How to Assess ILD in Patients (Dr. Janet Pope) and Management of SSc ILD (Dr. Alicia Hinze)

Longevity is a hot health topic, but what factors move the needle on not only how long you live but how long you experience relatively good health? Some lab and other tests can help assess how healthy you're aging and provide context for what lifestyle and other changes to make. Dr. Matt Kaeberlein and Mike Haney discuss the tests that help assess healthy aging, how mental health and physical health are intricately connected, which lifestyle factors might expand your health span, and where the research stands on various longevity topics.Get a Free Guide to Understanding Your Lab Results: https://levels.link/wnl

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Prognostic Value of Biomarkers in Cancer Patients Treated With Immune Checkpoint Inhibitor Therapy.

Dr. Luisa María Rivera is a critical biocultural anthropologist whose work examines how social inequality, trauma, and structural violence shape reproductive and maternal–infant health. She integrates ethnographic research with epigenomic and other molecular approaches to trace how stress during development can reverberate across generations and to understand the implications of these findings for health policy. Luisa earned her B.A. from Harvard (2008), an M.P.H. from the University of Minnesota (2015), and a Ph.D. in Anthropology from Emory University (2022). She is currently a Neukom Postdoctoral Fellow at Dartmouth College, mentored by Dr. Zaneta Thayer (Anthropology) and Dr. Brock Christensen (Geisel School of Medicine). Her research includes long-term work in post-war communities in Guatemala and with historically marginalized communities in the United States. Luisa previously joined the Sausage of Science “Hackademics” series in Episode 114, Dissertation Research in the Time of COVID-19. ------------------------------ Find the paper discussed in this episode: Vlasac, I. M., Stolrow, H. G., Thayer, Z. M., Christensen, B. C., & Rivera, L. (2025). DNA-based cell typing in menstrual effluent identifies cell type variation by sample collection method: toward noninvasive biomarker development for women's health. Epigenetics, 20(1), 2453275. https://doi.org/10.1080/15592294.2025.2453275 ------------------------------ Contact Luisa: E-mail: Luisa.Rivera@dartmouth.edu website: https://luisamariarivera.com/ Google Scholar ------------------------------ Contact the Sausage of Science Podcast and Human Biology Association: Facebook: facebook.com/groups/humanbiologyassociation/, Website: humbio.org, Twitter: @HumBioAssoc Chris Lynn, Host Website: cdlynn.people.ua.edu/, E-mail: cdlynn@ua.edu, Twitter:@Chris_Ly Cristina Gildee, Co-host, SoS Co-Producer, HBA Junior Fellow Website: cristinagildee.org, E-mail: cgildee@uw.edu,

In this rerun episode, we dig into the science behind what's happening inside our bodies with registered sports dietitian Ashley Reaver. Ashley highlights five key biomarkers that endurance athletes should pay attention to—explaining why they matter, what healthy ranges look like, and what steps we can take if our numbers are off. From performance to recovery, these biomarkers influence how well we train and how resilient we are to stress and fatigue. Ashley also shares practical strategies athletes can use to optimize their nutrition and overall health. With her background as a private practice dietitian, UC Berkeley instructor, and lead nutritional scientist at InsideTracker, Ashley brings both scientific depth and real-world application. Whether you're chasing new PRs or aiming for long-term health, this conversation offers valuable insights every runner can put into practice.  Check out her private practice Episode Sponsors: Janji, Use code TRAILRUNNER for 10% off Amazfit - T-Rex 3: Get 15% off JAMBAR: 20% off with code TRN20 Liquid IV, get 20% off your first order with code TRAILRUNNER Get the NEW "1 > 0" running hat HERE.  Limited supply

Relationship goals meet biohacking in this revealing conversation about how Sage Workinger-Brecka and Gary Brecka synchronize their health protocols while respecting their genetic differences. In this episode, they also answer your most-burning questions on children's nutrition, hormonal imbalance, ADHD symptoms, and mitochondrial health. Bonus: they share the exact mineral cocktail they drink daily, including their morning routines, which has been a game-changer for sustained energy without the afternoon crash.   Join the Ultimate Human VIP community for Gary Brecka's proven wellness protocols!: https://bit.ly/4ai0Xwg Connect with Sage Workinger-Brecka Website: http://bit.ly/3HGwUos Instagram: http://bit.ly/45PCvSz Facebook: http://bit.ly/4lZ4SlS Thank you to our partners H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa EIGHT SLEEP: SAVE $350 ON THE POD 4 ULTRA WITH CODE “GARY”: https://bit.ly/3WkLd6E COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp WHOOP: JOIN AND GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW MASA CHIPS: 20% OFF FIRST ORDER: https://bit.ly/40LVY4y VANDY: “ULTIMATE20” FOR 20% OFF: https://bit.ly/49Qr7WE AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij CARAWAY: “ULTIMATE” FOR 10% OFF: https://bit.ly/3Q1VmkC HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S BIOPTIMIZERS: “ULTIMATE” FOR 15% OFF: https://bit.ly/4inFfd7 RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: https://bit.ly/44fFza0 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC GENETIC TEST: ⁠https://bit.ly/3Yg1Uk9 Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 Intro of Show 02:43 Most Overlooked Thing by Couples 07:15 How to Improve Health and Relationship 09:09 What Does Your Fatigue Mean? 14:08 Habits that Influence Your Energy, Focus, and Mood 24:51 Top 3 Biomarkers to Track 26:37 Debunking Health Myths 34:39 Starting a Health Journey 37:41 How to Increase Mitochondrial Function Naturally 40:36 Best Supplements for Children 47:13 Biohacking during Pregnancy 50:00 Influencing Children to Take More Nutrient-Dense Foods 53:11 Supporting Children with ADHD 58:09 Coffee Alternatives to Boost Productivity 1:05:00 Overcoming Itchy Skin 1:08:45 Fasting and Weight Training  1:13:36 Biomarkers for Hormone Panel Test 1:18:30 Join The Ultimate Human VIP The Ultimate Human with Gary Brecka Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The Content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Learn more about your ad choices. Visit megaphone.fm/adchoices

My guest is Michael Snyder, PhD, professor of genetics at Stanford and an expert in understanding why people respond differently to various foods, supplements, behavioral and prescription interventions. We discuss how to optimize your health and lifespan according to what type of glucose responder you are, which genes you express, your lifestyle and other factors. Dr. Snyder also explains the key ages when you need to be particularly mindful about following certain health practices. We also discuss how people respond in opposite ways to different fiber types. This episode ought to be of interest and use to anyone seeking to understand their unique biological needs and how to go about meeting those needs. Sponsors AGZ by AG1: https://drinkag1.com/huberman Wealthfront*: https://wealthfront.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman *This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27,‬ 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable‭ APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer. Timestamps 00:00 Michael Snyder 03:33 Healthy Glucose Range, Continuous Glucose Monitors CGM, Hemoglobin A1c 09:02 Individual Variability & Food Choice, Glucose Spikes & Sleepiness 12:18 Sponsors: AGZ by AG1 & Wealthfront 15:16 Glucose Spikes, Tools: Post-Meal Brisk Walk; Soleus “Push-Ups”; Exercise Snacks 21:06 Glucose Dysregulation, Diabetes & Sub-Phenotypes, Tool: Larger Morning Meal 28:34 Exercise Timing, Muscle Insulin Resistance 30:49 Diabetes Subtyping, Weight, Glucose Control; Incretins 35:41 GLP-1 Agonists, Diabetes, Tool: Muscle Maintenance & Resistance Training 38:40 Metformin, Berberine, Headaches 41:01 GLP-1 Agonists, Cognition, Longevity, Tool: Habits Support Medication; Cycling 47:41 Subcutaneous vs Visceral Fat, Organ Stress 49:10 Sponsors: David & Eight Sleep 51:58 Meal Timing & Sleep, Tools: Post-Dinner Walk, Routines, Bedtime Consistency 57:16 Microbiome, Immune System & Gut; Diet & Individual Variability 1:02:52 Fiber Types, Cholesterol & Glucose, Polyphenols 1:09:50 Food As Medicine; Fiber, Microbiome & Individual Variability; Probiotics 1:18:48 Sponsor: Function 1:20:35 Profiling Healthy Individuals, Genomes, Wearables 1:26:31 Whole-Body MRIs, Nodules, Healthy Baseline, Early Diagnosis 1:34:07 Sensors, CGM, Sleep, Heart Rate Variability HRV, Tools: Mindset Effects, Increase REM 1:39:30 HRV, Sleep, Exercise, Tool: Long Exhales; Next-Day Excitement & Sleep 1:42:48 Organ Aging, “Ageotypes”; Biological Age vs Chronological Age 1:49:41 Longevity, Health Span, Genetics, Blue Zones 1:52:19 Epigenetics, Viral Infection & Disease 1:58:54 ALS, Heritability; Neuroprotection, Nicotine 2:03:47 Air Quality, Allergies, DEET & Pesticides, Inflammation, Mold; Microplastics 2:15:02 Single-Drop Blood Test & Biomarkers, Wearables, Observational Trials 2:20:33 Acupuncture, Blood Pressure 2:26:40 Immersive Events & Mental Health Benefits 2:34:59 Data, Nutrition & Lifestyle; Siloed Health Care vs Personalized Medicine 2:43:06 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

If you found out earlier on in your youth that you actually have a genetic propensity toward addiction, would you have made decisions a lot differently? Addiction is a bio-psycho-social model, but we don't really look at the biology part of it. Sometimes, we have to look at the physiology of things to understand addiction better. And there has to be a paradigm shift in thinking about how we operate and exist in this world. On today's episode, Duane speaks with Dr. Evelyn Higgins about genes and biomarkers, how they influence our behavior, how they play out in addiction, and why knowing about this part of ourselves is an important step in addiction treatment and recovery. Dr. Evelyn Higgins is the founder and CEO of Wired For Addiction and a recognized international expert in the epidemiology of addiction. With 34 years in clinical practice, Dr. Higgins has spent over 16 years dedicated to research and development in the science of addiction recovery, and she finds herself at the nexus of epigenetics, neuroscience, and addiction. In this episode, you will hear:What it means to look at errors in genetic codingEpigenetics and aberrant behaviorsWhy addiction is not a moral flaw, but a diseaseThe first step is getting objective information.The common genetic markers of addictionHow seeing addiction from a biological perspective impacts the familiesFollow and Review:We'd love for you to follow us if you haven't yet. Click that purple '+' in the top right corner of your Apple Podcasts app. We'd love it even more if you could drop a review or 5-star rating over on Apple Podcasts. Simply select “Ratings and Reviews” and “Write a Review” then a quick line with your favorite part of the episode. It only takes a second and it helps spread the word about the podcast.Supporting Resources:Wired For AddictionDr. Higgins' TEDTalk: NovusMindfulLife.comhttps://www.theaddictedmind.com/community Follow and Review: We'd love it even more if you could drop a review or 5-star rating over on Apple Podcasts. Simply select “Ratings and Reviews” and “Write a Review” then a quick line with your favorite part of the episode. It only takes a second and it helps spread the word about the podcast. If you live in California and are looking for counseling or therapy please check out Novus Mindful Life Counseling and Recovery CenterNovusMindfulLife.comWe want to hear from you. Leave us a message or ask us a question: https://www.speakpipe.com/addictedmindDisclaimerSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Drs. Petri and Fava review non-invasive biomarkers in systemic lupus erythematosus, including urine proteomics.

What if aging wasn't just something that happens to us, but something science could actually slow down? That's the question at the heart of today's conversation with Dr. Matt Kaeberlein, who's a leading scientist and longevity researcher at the University of Washington.Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer's to see what the latest science is telling us about extending healthspan.It is an informative discussion on whether aging itself can be slowed or reversed. If you're curious about how close we really are to changing the rules of aging, this could be worth a watch.Chapters00:00 – Introduction & The Biology of Aging Across Species10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep14:33 – The Hallmarks of Aging21:52 – Funding Issues23:22 – The Truth About Anti-Aging Drugs27:22 – Biological Age Testing 48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics01:02:50 – Micronutrient Testing and Supplements01:07:11 –  NAD, Smarter Longevity Choices01:18:05 –  Lithium's Secret Role in Aging and Memory Loss01:27:00 – Foundations of Longevity01:57:37 - Ovarian Aging02:01:02 – Closing Thoughts & Where to Find the Guest Guest's socials + websiteYouTube: https://www.youtube.com/@optispanX: https://x.com/mkaeberlein?lang=enWebsite: https://www.optispan.life/ Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

What if aging wasn't just something that happens to us, but something science could actually slow down? That's the question at the heart of today's conversation with Dr. Matt Kaeberlein, who's a leading scientist and longevity researcher at the University of Washington.Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer's to see what the latest science is telling us about extending healthspan.It is an informative discussion on whether aging itself can be slowed or reversed. If you're curious about how close we really are to changing the rules of aging, this could be worth a watch.Chapters:00:00 – Introduction & The Biology of Aging Across Species10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep14:33 – The Hallmarks of Aging21:52 – Funding Issues23:22 – The Truth About Anti-Aging Drugs27:22 – Biological Age Testing 48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics01:02:50 – Micronutrient Testing and Supplements01:07:11 –  NAD, Smarter Longevity Choices01:18:05 –  Lithium's Secret Role in Aging and Memory Loss01:27:00 – Foundations of Longevity01:57:37 - Ovarian Aging02:01:02 – Closing Thoughts & Where to Find the Guest Guest's socials + website:YouTube: https://www.youtube.com/@optispanX: https://x.com/mkaeberlein?lang=enWebsite: https://www.optispan.life/ Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurable age reversal using epigenetic clocks.Eric explains how removing and replacing plasma can dilute pro-aging factors in the blood, a concept inspired by earlier animal studies on parabiosis. He also describes why rigorous, placebo-controlled human trials are crucial for validating longevity interventions and distinguishing the field from hype-driven wellness trends.The episode also highlights how omics data, such as metabolomics and proteomics, are shaping a new era of precision aging research. Eric emphasizes the value of lifestyle interventions as a foundation and sees future opportunities in combining TPE with personalized strategies to extend healthspan.  Guest-at-a-Glance

Alzheimer's is not inevitable—and it may even be optional. In this groundbreaking episode, you'll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer's researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer's is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance. Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You'll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life. This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You'll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee. You'll Learn: • Why Alzheimer's can begin as early as your 20s and what biomarkers to track • The seven major drivers of Alzheimer's and how to reverse them with biohacking strategies • How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it • The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity • Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s • How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alzheimer's prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer's, Paraquat Parkinson's risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer's, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine Thank you to our sponsors! EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Resources: • Dale's Website: https://www.apollohealthco.com/dr-bredesen/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 2:43 — Personal Story 7:52 — APOE4, Genetics, and Drug Development 11:37 — Pharma, Media, and Pushback 17:13 — Prevention, Stages, and Biomarkers 23:34 — Causes and Mechanisms 30:24 — Parkinson's, Toxins, and Mitochondria 37:17 — Longevity, Biohacking, and Protocols 44:11 — AI, Data, and Future Treatments 54:11 — Case Studies and Success Stories 1:03:00 — Detox, Mold, and Environmental Triggers 1:12:00 — Neuroplasticity and Brain Regeneration 1:20:00 — Hormones, Supplements, and Personalized Hacks 1:29:00 — Cortisol, Addison's, and AI Protocols 1:38:00 — Large-Scale Trials and Global Impact 1:45:00 — Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode of Space Nuts is brought to you with the support of NordVPN. Protect your online privacy and access with our special deal by visiting www.nordvpn.com/spacenuts or use the promo code SPACENUTS at checkout.Cosmic Mysteries: Little Red Dots and Astronomical AchievementsIn this exciting episode of Space Nuts, hosts Heidi Campo and Professor Fred Watson explore the latest discoveries and breakthroughs in astronomy. From the intriguing mystery of the "little red dots" observed by the James Webb Space Telescope to the historic appointment of the first female Astronomer Royal, this episode is packed with cosmic insights and fascinating stories.Episode Highlights:- The Mystery of the Little Red Dots: Fred delves into the enigma surrounding the bright, red galaxies identified by the James Webb Space Telescope. He explains their significance, formation theories, and how they might provide a glimpse into the early universe, dating back nearly 12 billion years.- Celebrating Michelle Doherty: The hosts proudly announce the appointment of Michelle Doherty as the first female Astronomer Royal in over 300 years. Fred highlights her groundbreaking contributions to planetary science and her pivotal role in major NASA missions, including the Cassini mission to Saturn.- Detecting Life on Mars: A groundbreaking new test developed by researchers in the UK shows promise for detecting signs of life on Mars using existing rover technology. Fred discusses how this test could revolutionize our search for extraterrestrial life by analyzing chemical bonds in cell membranes.- SpaceX's Starship Launches: The episode wraps up with an update on SpaceX's ambitious Starship program, discussing the challenges and successes of recent launches. Fred reflects on the engineering feats and the importance of these missions for future lunar exploration.For more Space Nuts, including our continuously updating newsfeed and to listen to all our episodes, visit our website. Follow us on social media at SpaceNutsPod on Facebook, X, YouTube Music Music, Tumblr, Instagram, and TikTok. We love engaging with our community, so be sure to drop us a message or comment on your favorite platform.If you'd like to help support Space Nuts and join our growing family of insiders for commercial-free episodes and more, visit spacenutspodcast.com/aboutStay curious, keep looking up, and join us next time for more stellar insights and cosmic wonders. Until then, clear skies and happy stargazing.Got a question for our Q&A episode? https://spacenutspodcast.com/amaBecome a supporter of this podcast: https://www.spreaker.com/podcast/space-nuts-astronomy-insights-cosmic-discoveries--2631155/support.

In this episode, we take a critical look at the longevity movement and explore the most valuable—yet elusive—biomarkers for athletes. Learn more about your ad choices. Visit megaphone.fm/adchoices