Podcasts about biomarkers

Florence Comite, MD, a Yale-trained endocrinologist, precision-medicine pioneer, and author of Invincible, explains the five biomarkers that reveal how well you're aging and explores testosterone, metabolic health, cardiovascular risk, biological-age testing, sleep, fertility, and the early warning signs of future disease.This episode is proudly sponsored by:Jaspr is a powerful and beautiful at home air-scrubber that passively makes your home environment healthier by removing allergens, VOCs, dust, pollen, and more, from the air. Get $200 off each one you purchase at https://jaspr.co/genius using code GENIUS.I sleep on an Avocado mattress because real organic materials, no synthetic shortcuts, and better breathability make a noticeable difference. Go to ⁠http://avocadogreenmattress.com/MAX⁠ to check out their mattress and bedding sale.

How much can a 30-second voice clip tell you about your sleep, hydration, and stress levels? Today, I'm joined by Alex Fredericks, the founder of Tonewell, an innovative platform that analyzes the complex waveform and timbre of your voice to deliver highly accurate, actionable wellness reports.Alex breaks down the hard science behind frequency mapping, his transition from the music industry to high-tech wellness, and the hard-hitting entrepreneurial lessons he's learned protecting his peace. We have a refreshing conversation about escaping the data-tracking hamster wheel, setting unapologetic boundaries, and his daily non-negotiables: from daily BJJ and getting his hands in the garden dirt, to his remarkably basic (and hilarious) skincare routine.In this episode, we cover:The jump from music-industry oscilloscopes to wellness frequency.How Tonewell uses Fast Fourier Transfer (FFT) technology to map thousands of biomarkers in five minutes.Escaping data overload: Why choices are more powerful than data.The true definition of success: Time ownership and protecting your boundaries.Non-negotiables for grounding: Barefoot in the garden, daily BJJ, and the ultimate minimalist skincare.Check out Tonewell: tonewell.coConnect with Alex: alexfredericks.comFollow my day-to-day as an NYC creator: https://www.instagram.com/leaura

I sat down with Dr. Jordan Metzl, a sports-medicine physician who's convinced that the reason most of us can't stay consistent isn't discipline or knowledge, it's motivation, and he says you can actually engineer it by "lowering the cost to act." We get into exercise as a literal medicine that would beat almost any drug if it came in a pill, why fun is the real holy grail of compliance, and how movement can go head-to-head with antidepressants for everyday anxiety and depression. If you've been white-knuckling your way through willpower and losing, this one's going to change how you think about getting off the couch. CLICK HERE TO BECOME GARY'S VIP!: https://bit.ly/4ai0Xwg Get Dr. Jordan Metzl's book, “Push: Unlock the Science of Fitness Motivation to Embrace Health and Longevity”: https://bit.ly/4f28xiO Connect with Dr. Jordan Metzl Website: https://bit.ly/4gzA0tp  Instagram: https://bit.ly/4aRhbhA  Facebook: https://bit.ly/4fdR45E  X: https://bit.ly/4aP5Mig   Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp CYMBIOTIKA: "ULTIMATE20" FOR 20% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TAB: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 - ​Intro of Show 02:00 - From family of doctors to sports medicine 04:00 - Prescribing the medicine of exercise 05:55 - What an exercise prescription looks like 07:41 - The 1950s London Transport study 10:22 - Cellular adaptations and mitochondria 11:52 - Inflammation and chronic disease 13:31 - Immuno-fatigue and the theory of aging 14:45 - Motivation, not discipline, is missing 18:14 - Knowledge, emotion, and belief 20:25 - Building a fitness community 24:11 - Biomarkers and the cost of chronic disease 26:23 - Lifespan vs healthspan gap 28:26 - Fun is the holy grail of compliance 34:00 - Why remote work hurts our health 39:16 - Making exercise pay for doctors 41:01 - Two minutes of vigorous activity a day 44:30 - The GLP-1 and arthritic knee study 48:49 - Exercise vs antidepressants 55:38 - Lowering the cost to act 59:42 - What it means to be an Ultimate Human 1:01:29 - Alice: a marathon at 70 Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.  Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

Can neuroscience strengthen your faith? In this thought-provoking episode of inContext, Michael Easley sits down with neuroscientist Dr. Robyn Honea, whose research has focused on Alzheimer's disease, brain imaging, and neuroplasticity for more than two decades. Together, they explore what modern neuroscience reveals about the incredible design of the human brain—and why our ultimate hope is found not in biohacking or longevity, but in Christ. Dr. Honea shares how years of studying the aging brain led her to publicly integrate her Christian faith with her scientific work. They discuss the fear of dementia, the promise and limitations of medical advances, the role of exercise and healthy habits in brain health, and why believers should steward their bodies without making health an idol. Whether you're caring for aging parents, interested in neuroscience, working in healthcare, or simply wondering how faith and science fit together, this conversation offers biblical wisdom, scientific insight, and lasting encouragement. Topics Covered: Neuroplasticity explained Alzheimer's research and brain imaging Faith and science working together The fear of aging and dementia Brain health, exercise, and lifestyle Supplements, longevity, and biohacking Romans 12 and renewing your mind Music, memory, and dementia Why our identity is more than biology Living with hope as we grow older Chapters 00:00 – Introduction and Meet Dr. Robyn Honea 02:20 – From Schizophrenia Research to Alzheimer's Disease 05:00 – What Is Neuroplasticity? 08:30 – Why Dr. Honea Began Writing About Faith and Science 11:00 – What the Bible Says About Aging 13:00 – Can We Outsmart Aging? 15:15 – Supplements, Longevity & Health Culture 18:00 – Integrating Faith into a Scientific Career 22:15 – The Fear of Aging and Cognitive Decline 26:00 – Brain Scans, Biomarkers & Medical Wisdom 33:00 – Trusting God Instead of Living in Fear 35:00 – Why Music Unlocks Memory in Dementia 37:00 – Romans 12 and Renewing Your Mind 41:00 – Finding Identity Beyond Biology 47:30 – Does Someone with Dementia Still Know You're There? 49:30 – Final Encouragement and Closing Links Mentioned The Honea Lab The Brain God Designed on Substack Watch the highlights and full version of this interview on our Youtube channel. For more inContext interviews, click here.

Why does staying healthy feel harder than it should? In this episode of Beyond the Biomarkers, Kerri Rachelle explores a different perspective on the chronic disease epidemic. What if the problem isn't that we've become lazy or lost our willpower? What if we've simply built a world that's optimized for convenience, speed, and productivity—but not for human biology? You'll learn why your body is often responding exactly as it's designed to, how your environment influences everything from metabolism and energy to inflammation and recovery, and why lasting health is less about motivation and more about intentional design. Rather than chasing perfection, this episode will help you rethink the way you approach your health—one small decision at a time. In this episode, you'll learn: Why healthy choices often feel harder than they should How modern life has changed faster than human biology Why your body isn't broken—it's adapting The role of movement, sleep, relationships, purpose, and environment in long-term health Why motivation fades but good environments create lasting habits How to become an active participant in your own healthcare Simple ways to start designing a life that supports your biology Memorable Takeaways Your body isn't working against you—it's responding to the environment it's been given. The question isn't whether your body is adapting. The question is: what is it adapting to? Health isn't something you find. It's something you design. If this episode resonated with you, share it with someone who needs the reminder that better health isn't built overnight—it's built one decision at a time. Ready for personalized guidance? Our team of functional medicine dietitians at REV0lution helps people across the country uncover root causes, interpret labs, and build sustainable health plans that fit real life. Request an appointment at REV0lution.com. Because our health truly is our happiness.

Which imaging biomarkers matter most at diagnosis of GA, and how should they shape the decision to treat? In episode 1 of the GA in Practice miniseries on New Retina Radio, moderator Geeta Lalwani, MD, and panelists Murtaza Adam, MD, and Carl Danzig, MD, review the practical role of fundus autofluorescence and OCT in identifying high-risk GA, discuss ellipsoid zone integrity as an emerging endpoint, and work through a hypothetical case of an active, motivated patient with bilateral extrafoveal GA and good vision to explore how lifestyle, lesion characteristics, and patient education factor into early treatment decisions.

The Ultimate Health Assessment: 400 Biomarkers That Could Save Your Life www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Dr. Clint Phillips - MediciMedici Website:Personal Website: Instagram: @medicihealthDr. Gabi AppIn this episode of Over 40 Fitness Hacks, host Brad Williams sits down with Dr. Clint Phillips, founder of Medici Health, to discuss the future of personalized medicine, AI-driven health optimization, peptides, and preventative healthcare.Dr. Phillips shares his deeply personal journey into longevity science, explaining how losing multiple family members at a young age inspired him to dedicate his career to helping people live longer, healthier lives. After building a successful chiropractic and rehabilitation practice in Aspen, Colorado, and later co-founding a medical second-opinion company following his daughter's stroke, he launched Medici Health with one mission: prevent disease before it starts.The conversation dives into Medici's comprehensive annual health assessment, which collects over 400 health data points through advanced blood testing, DNA analysis, DEXA scans, vascular imaging, skin AI analysis, cancer screening, balance testing, and more. Rather than treating disease after it develops, Medici focuses on identifying each person's unique risk factors and creating highly personalized strategies based on genetics, biomarkers, and lifestyle.Brad and Dr. Phillips discuss why personalized medicine is replacing the "one-size-fits-all" approach to health, highlighting examples where simple lifestyle changes—guided by genetic testing—can dramatically reduce disease risk. They also explore the growing role of artificial intelligence in healthcare, including Medici's AI assistant, Dr. Gabby, which helps users interpret health data, evaluate supplements, scan food products, and even estimate cardiovascular risk using only a smartphone camera.The discussion also covers the rapidly growing field of peptides. Dr. Phillips explains why peptides show tremendous promise for longevity and recovery but emphasizes that they should always be paired with proper laboratory monitoring rather than taken blindly. Brad agrees that objective testing is essential since feeling better doesn't always mean your body is responding positively.Throughout the interview, both emphasize that true health isn't simply avoiding illness—it's building resilience through exercise, nutrition, preventative testing, personalized care, and consistent habits. Dr. Phillips also praises personal trainers as some of the most influential professionals in preventive healthcare, reinforcing Brad's philosophy that fitness coaching remains one of the best investments people over 40 can make.Whether you're interested in biohacking, longevity, AI-powered healthcare, preventative medicine, or simply maximizing your healthspan, this episode provides an insightful look at where the future of healthcare is heading and how personalized data may soon replace generic health advice.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at brad@over40fitnesshacks.com or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzVDisclaimer: The information provided on this podcast, including interviews and recommendations, is for educational and entertainment purposes only. It does not constitute medical, nutritional, or professional fitness advice. The hosts and guests are not your personal doctors or trainers. Always consult a qualified medical professional before changing your diet, starting a new exercise regimen, or implementing any advice heard on this show. Use of any information provided is solely at your own risk.

What if the real reason most businesses fail isn't strategy or market fit, but the behavior and value system of the owner themselves? In this episode, Sean sits down with Jay Aldebert, a business consultant who has studied patterns across 88,000 businesses and identified 11 biomarkers that predict whether a company will thrive or struggle. Jay explains why he starts every client conversation with a single pointed question about profit, and how the answer reveals far more than most owners expect. He shares why education has to come before measurement, drawing a parallel to how doctors measure without explaining, and why changing an owner's value system is often the hardest and most important part of the work. If you have ever wondered why smart, driven business owners keep hitting the same walls, Jay's framework will give you a completely new lens for looking at your own business.──────────────────────────────────────────────────────

Welcome to MS Research Briefs, a new ECTRIMS podcast series delivering an expert guided tour of important new studies in multiple sclerosis research. In each episode, leading MS experts will take a small number of recently published studies and go beyond the headline findings – exploring what the research shows and how it may influence clinical practice and future discovery. In this inaugural episode, Prof. Alan Thompson and Prof. Olga Ciccarelli discuss two studies exploring how advanced MRI biomarkers and machine learning may transform the diagnosis and prognosis of multiple sclerosis. Featured Publications Paramagnetic Rim Lesions and Development of Clinical MS in Radiologically Isolated Syndrome.JAMA Neurology. 2026;83(3):250–258. Machine learning-based combination of the central vein sign, cortical lesions and paramagnetic rim lesions: a web-based tool for the diagnosis of multiple sclerosis.Brain Communications. 2026;8(2):fcag079. Discussed in this episode Can paramagnetic rim lesions identify individuals with radiologically isolated syndrome (RIS) who are most likely to develop clinical MS? Why do paramagnetic rim lesions appear to be stronger prognostic biomarkers while the central vein sign remains a powerful diagnostic biomarker? Can machine learning models combining MRI biomarkers outperform traditional dissemination-in-space criteria? What role might advanced MRI biomarkers play in future diagnostic criteria and treatment decisions? How close are we to AI-supported diagnosis and automated biomarker detection in routine clinical practice? As advanced MRI biomarkers move from research tools towards clinically meaningful decision-making, this episode explores one of the most important developments in contemporary MS research.

Paul Lingor, MD, is Professor for Neurology, Group Leader and Head of the Outpatient Clinics for Motoneuron Disorders and Co-head of the Outpatient Clinics for Movement Disorders and at the Department of Neurology of the TUM Klinikum Rechts der Isar in Munich, Germany.  Here he discusses the recent publication "Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial."

Could a blood test finally provide answers for millions living with chronic fatigue syndrome (CFS/ME)? In this episode, Alexandre Akoulitchev and Dmitry Pshezhetskiy reveal a groundbreaking approach using epigenetic biomarkers to detect biological signatures associated with this complex, hard-to-diagnose condition. Their work leverages cutting-edge molecular medicine and translational research to provide earlier, more objective detection of CFS/ME—offering hope for patients who have long struggled with uncertainty and delayed diagnoses. In this conversation, we explore: ·       How a blood-based biomarker test may identify chronic fatigue syndrome more reliably. ·       The role of epigenetics in understanding invisible, multi-system illnesses. ·       The four core symptoms of CFS/ME and why conventional diagnostics often fail. ·       How inflammation and immune signals contribute to fatigue and disease progression. Alexandre Akoulitchev, cofounder of Oxford BioDynamics and creator of the EpiSwitch biomarker platform, and Dmitry Pshezhetskiy, Professorial Research Fellow at Norwich Medical School, bring decades of expertise in molecular biology, genome regulation, and translational research to this discussion. Learn more about Alexandre Akoulitchev here and Dmitry Pshezhetskiy here. Episode also available on Apple Podcasts: https://apple.co/38oMlMr 

Hermansky-Pudlak syndrome (HPS) is a rare genetic disorder that causes albinism, bleeding problems, and a high risk of developing pulmonary fibrosis. However, patients with HPS provide an important population for researchers looking for biomarkers that predict the onset and progression of pulmonary fibrosis. On this ATS Breathe Easy podcast episode, expert Resat Cinar, PhD, MBA, National Institute on Alcohol Abuse and Alcoholism, and patient advocate and founder of the Hermansky-Pudlak Syndrome Network Donna Appell, RN, discuss how HPS has helped researchers better understand pulmonary fibrosis, and how research on rare diseases can generate insights that benefit much larger patient populations. 

In this episode, Michel Mommejat, President of A.D.A.M. Innovations, shares how genomics and AI are transforming healthcare from reactive treatment to preventative wellcare. Recorded in Tokyo, this conversation explores what your DNA can reveal as a biological blueprint, why Japan serves as the world's laboratory for healthy aging, and how combining genetic data with biomarkers and lifestyle information creates a dynamic, personalized health ecosystem. Michel also discusses the ethical frameworks needed to protect the most sensitive data that exists, the concept of Artificial General Gene Intelligence, and practical applications like pharmacogenomics that are already changing how we think about medication. Tune in for a visionary conversation on the future of health and longevity.

The migraine pain is gone… so why do you still feel exhausted, emotional, foggy, or completely drained afterward?In this episode of The Migraine Heroes Podcast, host Diane Ducarme explores the often-overlooked “migraine hangover” phase — also known as the postdrome stage. Blending neuroscience with holistic healing insights, this episode explains why your brain and nervous system may still be recovering long after the pain disappears.You'll discover:

On this, our 331st Evolutionary Lens livestream, we discuss sunscreen and vegans. It's Summer, and the sun is out! Should you slather yourself in sunscreen, stay indoors, or seek moderate exposure to the sun that grows in intensity that more your skin becomes acclimated to the season? The last, of course. Research has found that sunscreen use may be positively correlated with skin cancer, but a) “sunscreen” is not just one thing, and most but not all sunscreen is positively toxic, and b) all cause mortality is lower in people who get regular (non-sunscreened) sun exposure, so even if sunscreen does lower your risk of skin cancer—the sun is protecting your health in other ways. Also consider ditching the sunglasses, and donning a hat. Then: even the New York Times can't figure out whose team they're on, as a vegan in Portland tries to get Oregonians to outlaw hunting, fishing, animal research, conventional livestock production, and “lethal pest control.”*****Our sponsors:Mud/WTR: Start your new morning ritual & get up to 43% off your @MUDWTR with code DarkHorse at http://mudwtr.com/DarkHorse #mudwtrpodCaraway: save up to $230 on the 12 piece cookware set vs buying the products individually; include minis duo & save up to $350. Visit http://Carawayhome.com/DarkHorse to take an additional 10% off using code DarkHorse on your next purchase.Puori: Clean and safe supplements, lab tested and guaranteed. Go to http://Puori.com/DarkHorse for 32% off grass-fed whey protein with a subscription. DarkHorse code works on all products!*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comHeather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.orgMusic: "Marble Machine" by WintergatanThis track can be downloaded for free at www.wintergatan.netFree License to use this track in your video can be downloaded at www.wintergatan.net*****Mentioned in this episode:Hulscher's substack: https://www.thefocalpoints.com/p/study-finds-sunscreen-use-linkedJeremian et al 2023. Gene–Environment analyses in a UK biobank skin Cancer cohort identifies important SNPs in DNA repair genes that may help prognosticate disease risk. Cancer Epidemiology, Biomarkers & Prevention, 32(11): 1599-1607: https://pmc.ncbi.nlm.nih.gov/articles/PMC10840669/pdf/nihms-1929398.pdfNicholson & Exley, C 2007. Aluminum: a potential pro-oxidant in sunscreens/sunblocks? Free Radical Biology and Medicine, 43(8): 1216-1217: https://www.ovid.com/journals/frbm/abstract/10.1016/j.freeradbiomed.2007.07.010~aluminum-a-potential-pro-oxidant-in-sunscreenssunblocksHunter-Gatherer's Guide: https://amzn.to/3AGANGg (commission earned)NYT in Oregon: https://www.nytimes.com/2026/06/21/us/politics/animal-rights-cruelty-oregon.htmlSupport the show

On this episode host Beth Friedman engages Bobby Reddy, Jr., PhD, Co-founder & CEO, Prenosis. Sepsis kills more people annually than all cancers combined - yet it receives a fraction of the research investment. Beth sits with Bobby Reddy Jr., leading Prenosis, a precision medicine company redefining how hospitals understand and treat their most critically ill patients. Reddy explains why decades of clinical trials for sepsis, acute heart failure, and pneumonia have failed and why the solution lies not in new drugs but in recognizing that these are not single diseases at all. Discover how Prenosis is using AI, deep biomarker data, and real-time EHR integration to characterize each patient's unique biology in under an hour, and what a landmark BARDA-funded trial could mean for the future of critical care.

Most athletes get routine blood work.Very few understand which biomarkers truly matter for performance, recovery, and longevity.In this episode of Find Your Edge, Coach Chris Newport and dietetic intern Emily Qiu break down the special lab values endurance athletes should know about and why they matter.We discuss:• CBC and CMP basics• ApoB and cardiovascular risk• Magnesium and athletic performance• Vitamin B12 and MMA• Homocysteine and longevity• Vitamin D and bone health• Why athletes need personalized interpretation• How biomarker trends help you make smarter decisionsIf you've ever felt like you're doing everything right but still not seeing the results you want, this episode is for you.Because the goal isn't more information.The goal is clarity.Learn more about the Endurance Edge Longevity Lab:https://www.theenduranceedge.com/longevity/Check out the episode here: https://www.theenduranceedge.com/special-lab-values-endurance-athletes-biomarkers Support the show

Each month, we will highlight a paper published in Aging chosen as the “Editors' Choice.” These selections are handpicked by our editors and accompanied by a brief summary, showcasing research with significant impact and novel insights in aging and age-related diseases. This exploratory randomized controlled trial, titled “Short-term responsiveness of DNA methylation–based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing Bifidobacterium longum BB536: an exploratory randomized controlled trial,” investigated whether a 12-week lifestyle intervention combining exercise, dietary guidance, and daily consumption of yogurt containing Bifidobacterium longum BB536 could influence biological aging. The researchers found a significant slowing of the DNA methylation-based pace of aging measure DunedinPACE in overweight men aged 50 and older, suggesting that feasible lifestyle changes may be associated with short-term improvements in selected epigenetic aging biomarkers. DOI - https://doi.org/10.18632/aging.206386 Corresponding author - Yukihiro Hishida - yukihiro-hishida639@morinagamilk.co.jp Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206386 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, DNA methylation clock, DunedinPACE, Multicomponent lifestyle intervention, Bifidobacterium longum BB536 To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

What matters most to patients with non-muscle invasive bladder cancer (NMIBC)? In this episode of BackTable Urology, Dr. Kelly Bree, Dr. Saum Ghodoussipour, and Meredith Donahue, N.P., join host Dr. Vignesh Packiam to discuss the power of shared decision-making across the NMIBC spectrum. They explore risk-adapted treatment selection, when to escalate or de-escalate therapy, and how to navigate conversations about recurrence risk, treatment burden, quality of life, and the possibility of cystectomy. --- Get the BackTable apphttps://www.backtable.com/app --- This podcast is supported by an educational grant from Johnson & Johnson. --- Timestamps 00:00 - Introduction01:55 - Second Opinions and Patient Counseling06:08 - Intermediate Risk Stratification12:13 - Treatment Options for Intermediate Risk NMIBC16:20 - BCG and Alternative Treatments for High Risk NMIBC26:49 - Options for BCG-Unresponsive NMIBC31:42 - Sequencing and Cystectomy37:03 - Financial and Time Toxicity41:08 - Biomarkers and ctDNA44:04 - Future Trials and NMIBC Innovations --- More about this episode They also review emerging therapies such as ZUSDURI, the evolving role of intravesical treatments, and the promise of biomarkers and ctDNA for personalized care. The discussion covers practical strategies for patient counseling, key updates to clinical guidelines, and a preview of innovations shaping the future of NMIBC management. --- Resources Active Surveillance Versus Intravesical Bacillus Calmette-Guérin for High-grade T1 Bladder Cancer with Negative Second Transurethral Resection: The Randomized Noninferiority Phase 3 JCOG1019 Trial:https://pubmed.ncbi.nlm.nih.gov/41571573/ Twelve-Month Results From the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade Non–Muscle-Invasive Bladder Cancerhttps://ascopubs.org/doi/10.1200/JCO-25-01324 CIRCULATING TUMOR DNA AS A BIOMARKER FOR UPSTAGING AND ADVERSE PATHOLOGY IN HIGH-RISK NON–MUSCLE-INVASIVE BLADDER CANCER:https://www.auajournals.org/doi/abs/10.1097/01.JU.0001191388.74345.c9.09 Preoperative Circulating Tumor DNA Predicts Upstaging and Recurrence in High-Risk Nonmuscle-Invasive Bladder Cancer Undergoing Radical Cystectomyhttps://pubmed.ncbi.nlm.nih.gov/41843048/ --- BackTable Urology is the go-to podcast for urologists, urologic oncologists, and urogynecologists. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

Are medical advancements closing or widening medical disparities? Eugene Manley, Jr., Ph.D., founder and CEO of the STEMM & Cancer Health Equity Foundation, breaks down why equity is still not completely measurable in clinical trials, what proper representation in studies is, and how certain demographics are at a disadvantage for biomarker tests compared to other groups with host Deborah Borfitz. Their conversation explores whether health equity in cancer trials is different compared to commonly occurring diseases and if basket and umbrella trials may help the move the needle. Plus, the latest news on a pioneering phage therapy service, a unique cardiac arrest pilot study, new primary endpoints for cancer trials, and trial disruptions threatening diversity. Listen and let us know in a review: where do you think our time and resources are most needed for equity? Show Notes News Roundup Compassionate use phage therapy Article in Nature Medicine Press release from Monash University   Sudden cardiac death research  Study in Prehospital Emergency Care News on the University of Cincinnati website New endpoints for cancer trials Consensus paper in The Lancet Oncology News on the Medical University of Vienna website USC and Tempus strategic collaboration News on the Keck School of Medicine of USC website Trial disruptions threaten diversity Article in the Journal of Medical Internet Research Misinterpreting effects of Alzheimer's drugs Research letter in JAMA Neurology News from Brown University School of Public Health  Guest Eugene Manley, Jr., Ph.D., founder and CEO of the STEMM & Cancer Health Equity Foundation The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News senior writer, Deborah Borfitz, welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider's look at clinical research today.  

Depression is often treated as a single condition. But two people with the same diagnosis can have completely different underlying causes. On this episode of The Dr. Hyman Show, I'm rejoined by Dr. James Greenblatt to explore why depression may be less of a disease and more of a signal that something deeper is going on. We discuss how a root-cause approach can uncover what's driving symptoms and why finding what's beneath them matters. Watch the full conversation on YouTube or listen wherever you get your podcasts. We discuss: Could nutrient deficiencies, inflammation, or gut issues be contributing to symptoms of depression What tests can help uncover the biological factors that may be affecting mood and mental health Why can two people with depression have different root causes—and require different solutions How do blood sugar imbalances, hormone changes, and metabolic health influence the brain What should you know about antidepressants, tapering, and addressing the factors that may affect recovery Hope doesn't come from ignoring symptoms—it comes from understanding them. Sometimes the most important question isn't "What's wrong with me?" but "What might my body be trying to tell me?" One of the key themes in this conversation is that mental health is deeply connected to what's happening throughout the body. In my Brainshaping Academy, you'll learn how to support the biological systems that shape cognitive, emotional, and mental well-being. View Show Notes From This Episode Depression symptoms aren't always just “in your head.” Dr. Hyman's Brainshaping Academy shows how your gut, immune system, and nutrient levels may be responsible—and what you can do about it. → https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Seed, Made In Cookware, Perfect Amino, BON CHARGE, and Big Bold Health.Go to seed.com/hyman and use code 20HYMAN to get 20% off your first month.Visit madeincookware.com and use code HYMAN10 for 10% off your order.Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order.Head to boncharge.com/hyman and use code HYMAN for 15% off.Go to bigboldhealth.com/drhyman and use code HYMAN15 to save 15% on your first order. (0:00) Antidepressants, Cooking at Home, and Introducing the Brain Shaping Academy (3:14) Prevalence of Depression and Personal Stories (4:27) Exploring Root Causes of Depression (5:07) Influential Figures and Orthomolecular Psychiatry (12:29) Gut Health, Gluten Sensitivity, and Brain Inflammation (20:22) Neuroinflammation and Root Causes of Depression (22:10) Biomarkers, Hormonal Imbalances, and Insulin Resistance (25:34) The Role of Toxins and Diagnostic Testing (31:15) Case Studies and Patient Stories (34:29) Challenges in the Mental Health System (37:05) Effectiveness of Antidepressants and Patient Resistance (43:17) Role and Need for Nutritional Lithium (45:00) Sponsor: Big Bold Health (46:00) Identifying Nutritional Lithium Need (47:13) Integrating Modalities and Supplements vs. Medications (48:04) Psychotherapy Methods and Addressing Root Causes (49:34) Dr. Greenblatt's Book and the Finding a Living Platform (51:03) Systematic Approach and Global Impact of Depression (52:39) Sharing, Disclaimer, and Closing Remarks

Ready to move beyond “one-size-fits-all” for BCG-unresponsive NMIBC? In this episode of BackTable Urology, Dr. Ruchika Talwar hosts Dr. Sam Chang to discuss the evolving treatment landscape for BCG-unresponsive non-muscle invasive bladder cancer (NMIBC). They explore why BCG may fail, the science and clinical rationale behind new immunotherapies and gene therapies, practical approaches to patient selection, treatment sequencing, and surveillance, and the value of emerging biomarkers, empowering urologists to make more informed, personalized decisions in complex cases of NMIBC. --- Get the BackTable apphttps://www.backtable.com/app --- This podcast is supported by ImmunityBiohttps://anktiva.com/ --- Timestamps 00:00 - Introduction03:48 - BCG: How it Works and Why it Fails11:13 - Pembrolizumab Role and Limits14:38 - Nadofaragene firadenovec 16:34 - Cretostimogene grenadenorepvec18:39 - BCG + Anktiva Rationale29:50 - Explaining Options to Patients33:05 - Post Treatment Surveillance37:32 - Future of Biomarkers and AI42:05 - Key Takeaways --- Resources N-803 Plus BCG Treatment for BCG-Naïve or -Unresponsive Non-Muscle Invasive Bladder Cancer: A Plain Language Reviewhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11524197/ Safety, Tolerability, and Long-Term Clinical Outcomes of an IL-15 analogue (N-803) Admixed with Bacillus Calmette-Guérin (BCG) for the Treatment of Bladder Cancerhttps://doi.org/10.1080/2162402X.2021.1912885 IL-15 Superagonist NAI in BCG-Unresponsive Non–Muscle-Invasive Bladder Cancerhttps://evidence.nejm.org/doi/full/10.1056/EVIDoa2200167 --- More about this episode This podcast is for informational purposes only. The views and opinions expressed in this podcast are solely those of the moderator and individual guest. --- BackTable Urology is the go-to podcast for urologists, urologic oncologists, and urogynecologists. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

Dr. Yana Aznavour, CEO and Founder of Endometrics, discusses the significant diagnostic delay women face with endometriosis due to non-specific symptoms and the current reliance on invasive surgery for a definitive diagnosis. The company has developed a non-invasive at-home diagnostic test that uses menstrual blood to analyze a five-gene biomarker signature with high accuracy.  This objective, molecular-based test shortens the time to the correct treatment and changes the dynamic of the patient-doctor conversation. Yana explains, "We are developing non-invasive diagnostic tests, and we are primarily addressing the huge diagnostic delay that our patients, women, face, unfortunately. This happens because there are tons of non-specific symptoms and inconclusive imaging findings, and women face unnecessary appointments and procedures before reaching the point of definitive diagnosis. We are working rigorously towards bringing non-invasive, highly reliable diagnostic tests to help women get clarity and answers behind their symptoms way earlier in the journey."   "Menstrual pain and pain in general that women try to express and define at physician's appointments, it's being dismissed because they try to explain that, but in many cases, they cannot find exactly where it hurts, especially in endometriosis. Due to this, unfortunately, at the primary care level and the non-OB/GYN level, they're being dismissed and repeatedly misdiagnosed for years. The key reason is the non-specific symptoms because symptoms like pelvic pain and pain with urination overlap with the list of diagnoses. Currently, the definitive diagnosis for endometriosis is achieved through surgery. Nobody would do surgery after the first appointment. So, endometriosis becomes a diagnosis of exclusion, unfortunately, and it takes years before patients receive the final diagnosis." #Endometrics #Endometriosis, #WomensHealth, #Biomarkers, #Diagnostics, #FemTech #Gynecology #PrecisionMedicine endometrics.us Listen to the podcast here

Dr. Yana Aznavour, CEO and Founder of Endometrics, discusses the significant diagnostic delay women face with endometriosis due to non-specific symptoms and the current reliance on invasive surgery for a definitive diagnosis. The company has developed a non-invasive at-home diagnostic test that uses menstrual blood to analyze a five-gene biomarker signature with high accuracy.  This objective, molecular-based test shortens the time to the correct treatment and changes the dynamic of the patient-doctor conversation. Yana explains, "We are developing non-invasive diagnostic tests, and we are primarily addressing the huge diagnostic delay that our patients, women, face, unfortunately. This happens because there are tons of non-specific symptoms and inconclusive imaging findings, and women face unnecessary appointments and procedures before reaching the point of definitive diagnosis. We are working rigorously towards bringing non-invasive, highly reliable diagnostic tests to help women get clarity and answers behind their symptoms way earlier in the journey."   "Menstrual pain and pain in general that women try to express and define at physician's appointments, it's being dismissed because they try to explain that, but in many cases, they cannot find exactly where it hurts, especially in endometriosis. Due to this, unfortunately, at the primary care level and the non-OB/GYN level, they're being dismissed and repeatedly misdiagnosed for years. The key reason is the non-specific symptoms because symptoms like pelvic pain and pain with urination overlap with the list of diagnoses. Currently, the definitive diagnosis for endometriosis is achieved through surgery. Nobody would do surgery after the first appointment. So, endometriosis becomes a diagnosis of exclusion, unfortunately, and it takes years before patients receive the final diagnosis." #Endometrics #Endometriosis, #WomensHealth, #Biomarkers, #Diagnostics, #FemTech #Gynecology #PrecisionMedicine endometrics.us Download the transcript here

CardioNerds (Dr. Billy-Joe Mullinax, Dr. Dinu Balanescu, and Dr. Jane Ehret) discuss risk stratification in acute pulmonary embolism with Dr. Stavros Konstantinides, Chair of the 2019 ESC Pulmonary Embolism Guidelines. Using a real-world case, this episode explores how modern PE care has moved beyond “massive” and “submassive” labels toward a dynamic, physiology-based approach. The discussion highlights the limitations of static risk scores, the importance of right ventricular dysfunction and biomarkers, and why normotension does not imply stability. Special emphasis is placed on intermediate-high risk PE, early identification of impending hemodynamic collapse, and the role of lactate, serial reassessment, and PERT teams in guiding escalation of care. Audio editing by CardioNerds intern, Joshua Khorsandi.The 2026 American multi-society PE guidelines were published after this episode was recorded. Dr. Dinu Balanescu and Dr. Billy-Joe Mullinax are Co-chairs for the CardioNerds PE Series, developed in collaboration with the PERT Consortium.   Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Pulmonary Embolism PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls Stable blood pressure does not mean low risk in PEHypotension is a late finding. Patients may have severe RV failure, hypoxia, and tissue hypoperfusion while remaining normotensive — a key concept behind “normotensive shock.” Risk stratification in PE must be dynamic, not staticLegacy scores like PESI and Bova provide a snapshot and predict 30-day mortality, but they do not capture short-term trajectory or impending hemodynamic collapse. Intermediate-high risk PE is a dangerous and heterogeneous groupPatients with RV dysfunction, positive biomarkers, tachycardia, hypoxemia, and elevated lactate may have in-hospital mortality approaching 15%, rivaling STEMI. Lactate is a critical but underutilized marker in PEElevated lactate reflects tissue hypoxia and early circulatory failure and may identify patients at risk for collapse before blood pressure declines. PERT enables physiology-driven, patient-centered PE carePERT teams operationalize continuous reassessment, integrate imaging, labs, and clinical trajectory, and allow timely escalation — shifting PE management from rigid categories to real-time decision-making. Notes Drafted by Dr. Jane Ehret. 1. What is the contemporary framework for risk stratification in acute pulmonary embolism? Modern PE risk stratification prioritizes hemodynamics and right ventricular (RV) function rather than clot burden. The 2019 ESC Guidelines classify PE into high risk, intermediate risk (low vs high), and low risk, based on: Hemodynamic status, RV dysfunction on imaging, and Cardiac biomarkers. This framework emphasizes early mortality risk but requires clinical context to guide escalation decisions. 2. Why is normotension insufficient to define “stability” in PE? Blood pressure is a late marker of circulatory failure in PE. Patients can maintain normal BP through Tachycardia, Increased sympathetic tone, and RV compensation. Many patients with preserved BP may already have shock physiology, including hypoxemia, elevated lactate, and RV failure — sometimes referred to as “normotensive shock.” 3. How should intermediate-risk PE be conceptualized clinically? Intermediate-risk PE is heterogeneous, ranging from patients who do well on anticoagulation to those who deteriorate rapidly. Intermediate-high risk PE is defined by RV dysfunction on imaging and positive cardiac biomarkers. Clinical features such as tachycardia, increasing oxygen requirement, and elevated lactate identify patients at highest risk within this group. 4. What are the strengths and limitations of commonly used PE risk scores? Legacy scores are useful for initial risk categorization but are static and limited in predicting short-term deterioration. Most scores were developed to predict mortality or complications at fixed time points rather than dynamic clinical trajectory. 5. What are the commonly used risk scores and clinical tools in PE, and what is each designed to predict? ESC Risk Stratification Algorithm: Identifies high-risk PE by hemodynamics. Uses PESI or sPESI in normotensive patients to distinguish low-risk from non–low-risk PE. Uses RV dysfunction and biomarkers to differentiate intermediate-low from intermediate-high risk. Forms the basis of many institutional PE pathways. PESI and sPESI: Validated to predict 30-day mortality. Widely used to identify low-risk patients appropriate for outpatient management. Heavily influenced by age and comorbidities. Bova Score: Predicts 30-day PE-related complications in normotensive patients. Composite PE Shock Score (CPES): Predicts normotensive shock in hemodynamically stable PE patients. Pulmonary Embolism Progression (PEP) Score: Predicts progression from intermediate-risk to high-risk PE within 72 hours of diagnosis. PE Short-term Clinical Outcomes Risk Estimation (PE-SCORE): Predicts clinical deterioration or death within 5 days of PE diagnosis. Hestia Criteria: Identifies low-risk PE patients safe for outpatient treatment. Wells' Criteria and Revised Geneva Score: Determine pretest probability for diagnostic triage. PERC Score: Rules out PE in very low-risk patients. 6. What is the role of biomarkers in PE risk stratification? Troponin and natriuretic peptides reflect RV myocardial injury and strain. Current guidelines treat biomarkers as binary (positive vs negative), despite risk being continuous. Biomarkers are most helpful for: Initial risk classification. They are less useful for: Short-interval monitoring and Detecting rapid clinical deterioration. 7. Why is lactate an important physiologic marker in PE? Lactate reflects global tissue hypoxia and impaired perfusion. Elevated lactate may identify patients with: Early circulatory failure and Increased risk of imminent hemodynamic collapse. Lactate is not currently included in ESC risk algorithms but may add important prognostic information in intermediate-risk patients. 8. How does trajectory influence decision-making in PE management? Risk stratification should be viewed as a dynamic process, not a one-time label. Worsening clinical trajectory may include: Rising heart rate, Increasing oxygen needs, Rising lactate, and Progressive RV dysfunction. Serial reassessment is essential for timely escalation of care. 9. What role do Pulmonary Embolism Response Teams (PERT) play in risk stratification? PERT facilitates: Multidisciplinary decision-making and Integration of imaging, biomarkers, and clinical physiology. PERT is most valuable for: Intermediate-risk and high-risk PE and Patients with complex comorbidities or uncertain trajectory. PERT enables a shift from category-based to physiology-driven PE care. References 1. Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J. 2019;54(3):1901647. Published 2019 Oct 9. doi:10.1183/13993003.01647-2019 2. Leidi A, Bex S, Righini M, Berner A, Grosgurin O, Marti C. Risk Stratification in Patients with Acute Pulmonary Embolism: Current Evidence and Perspectives. J Clin Med. 2022;11(9):2533. Published 2022 Apr 30. doi:10.3390/jcm11092533 3. Choi WH, Kwon SU, Jwa YJ, et al. The pulmonary embolism severity index in predicting the prognosis of patients with pulmonary embolism. Korean J Intern Med. 2009;24(2):123-127. doi:10.3904/kjim.2009.24.2.123 4. Jiménez D, Aujesky D, Moores L, et al. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med. 2010;170(15):1383-1389. doi:10.1001/archinternmed.2010.199 5. Chen X, Shao X, Zhang Y, et al. Assessment of the Bova score for risk stratification of acute normotensive pulmonary embolism: A systematic review and meta-analysis. Thromb Res. 2020;193:99-106. doi:10.1016/j.thromres.2020.05.047 6. Zhang RS, Yuriditsky E, Zhang P, et al. Composite Pulmonary Embolism Shock Score and Risk of Adverse Outcomes in Patients With Pulmonary Embolism. Circ Cardiovasc Interv. 2024;17(8):e014088. doi:10.1161/CIRCINTERVENTIONS.124.014088 7. Zhang RS, Alam U, Sharp ASP, et al. Validating the Composite Pulmonary Embolism Shock Score for Predicting Normotensive Shock in Intermediate-Risk Pulmonary Embolism. Circ Cardiovasc Interv. 2024;17(2):e013399. doi:10.1161/CIRCINTERVENTIONS.123.013399 8. Ehret J, Wakefield D, Badlam J, Antkowiak M, Erdreich B. Development of the Pulmonary Embolism Progression (PEP) score for predicting short-term clinical deterioration in intermediate-risk pulmonary embolism: a single-center retrospective study. J Thromb Thrombolysis. 2025;58(2):243-253. doi:10.1007/s11239-024-03051-5 9. Weekes AJ, Raper JD, Lupez K, et al. Development and validation of a prognostic tool: Pulmonary embolism short-term clinical outcomes risk estimation (PE-SCORE). PLoS One. 2021;16(11):e0260036. Published 2021 Nov 18. doi:10.1371/journal.pone.0260036 10. Zondag W, Hiddinga BI, Crobach MJ, et al. Hestia criteria can discriminate high- from low-risk patients with pulmonary embolism. Eur Respir J. 2013;41(3):588-592. doi:10.1183/09031936.00030412 11. Wells PS, Anderson DR, Rodger M, et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer. Ann Intern Med. 2001;135(2):98-107. doi:10.7326/0003-4819-135-2-200107170-00010 12. Wolf SJ, McCubbin TR, Feldhaus KM, Faragher JP, Adcock DM. Prospective validation of Wells Criteria in the evaluation of patients with suspected pulmonary embolism. Ann Emerg Med. 2004;44(5):503-510. doi:10.1016/j.annemergmed.2004.04.002 13. Le Gal G, Righini M, Roy PM, et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med. 2006;144(3):165-171. doi:10.7326/0003-4819-144-3-200602070-00004 14. Kline JA, Mitchell AM, Kabrhel C, Richman PB, Courtney DM. Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J Thromb Haemost. 2004;2(8):1247-1255. doi:10.1111/j.1538-7836.2004.00790.x 15. Kline JA, Courtney DM, Kabrhel C, et al. Prospective multicenter evaluation of the pulmonary embolism rule-out criteria. J Thromb Haemost. 2008;6(5):772-780. doi:10.1111/j.1538-7836.2008.02944.x

In this first deep dive, Rachel Buckley joins host Catherine Glass to explore how Alzheimer's disease risk can be detected before symptoms appear. From blood-based biomarkers like p-tau217, to AI-driven models of cognitive resilience, the episode examines how risk, progression, and protection can be better understood and predicted over time. Timestamps: 00:00:57:11 – Phosphorylated tau and amyloid-PET 00:08:15:05 – Biomarkers, risk, and progression 00:11:18:04 – Brain resistance and cognitive resilience 00:15:23:23 – AI biases

In this episode of Joint Ventures, hosts Jack Arnold, MBBS, PhD, an academic clinical lecturer in rheumatology at the University of Leeds, and Rihards Buss, MD, a consultant rheumatologist at Freeman Hospital, Newcastle, preview their unofficial countdown of the sessions, themes, and abstracts they are most excited about heading into the 2026 European Alliance of Associations for Rheumatology (EULAR) Annual Meeting in London, June 3–6, including:  Obesity, Weight Management, and Psoriatic Arthritis Sessions Personalized Medicine and Biomarkers in RMDs Sessions Fatigue and Quality of Life in Connective Tissue Disease Session Mitochondrial DNA and Interferon: Upstream Drivers of Autoimmunity Session Artificial Intelligence and Pattern Recognition in Rheumatology Sessions Axial Imaging in Axial Spondyloarthritis Session Head-to-Head Superiority Trials in RA and PsA Sessions CAR-T and CAR-NK Therapies: Efficacy, Limits, and What Comes Next Sessions

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Johnny Mahlangu and Joseph Rocco on their articles published in volume 147 issue 9 of Blood.  Dr. Mahlangu discusses study details and next steps from "Efficacy and safety of marstacimab prophylaxis in hemophilia A/B with inhibitors: results from the phase 3 BASIS trial" which shows that bleeding was reduced by 93% with subcutaneous marstacimab. Dr. Rocco shares the development behind "CXCL9 as a novel prognostic marker to identify high-risk adults with hemophagocytic lymphohistiocytosis", and the insights gained from measuring a new surrogate marker of IFN-γ activity predicting severity and mortality.

In this episode I look at blood tests that tell us about what's going on with our biological processes in terms of our long term metabolic health and the blood markers are relevant.Hba1c control: https://pmc.ncbi.nlm.nih.gov/articles/PMC4933534/Fasting insulin: https://pubmed.ncbi.nlm.nih.gov/11118012/Vitamin D: https://pmc.ncbi.nlm.nih.gov/articles/PMC10002864/AST/ALT: https://pmc.ncbi.nlm.nih.gov/articles/PMC10346959/Triglycerides and HDL ratio: https://pmc.ncbi.nlm.nih.gov/articles/PMC11493158/ApoB: https://pmc.ncbi.nlm.nih.gov/articles/PMC11219008/HDL cholesterol: https://pmc.ncbi.nlm.nih.gov/articles/PMC6077683/Hs-CRP: https://pmc.ncbi.nlm.nih.gov/articles/PMC9650935/Homocysteine: https://pmc.ncbi.nlm.nih.gov/articles/PMC12564181/Uric Acid: https://pmc.ncbi.nlm.nih.gov/articles/PMC8624633/Do Health: https://dohealth.co/what-we-measure#wwm-step-1Save your life in slow motion and those of others by subscribing now and sharing. Thank you for listening and for your support. It means a lot to me. Hosted on Acast. See acast.com/privacy for more information.

AUA2026: Focus on: Biomarkers, MRI and PSMA PET Imaging in Prostate Cancer Webcast CME Available: https://cme.auanet.org/URL/FOCUS262ONL LEARNING OBJECTIVES: After participating in this CME activity, participants will be able to: 1. Critically appraise recent developments in imaging biomarkers and molecular diagnostics (e.g., genomic risk scores, liquid biopsy) and discuss how they complement MRI and PSMA PET in prostate cancer care. 2. Determine the optimal clinical scenarios (diagnostic, staging, recurrence, surveillance) in which PSMA PET/CT or PET/MRI adds value beyond conventional imaging. 3. Recognize potential pitfalls in PSMA PET interpretation — including false positives, false negatives, non–PSMA-expressing disease, and technical artifacts — and implement strategies to mitigate them. 4. Synthesize biomarker, MRI, and PSMA PET findings into a personalized management plan, including guiding biopsy, focal therapy, salvage therapy, or systemic treatments. 5. Select appropriate patients with radiorecurrent or organ-confined prostate cancer for advanced imaging and guide re-treatment decisions (e.g., salvage therapy, targeted radiotherapy). ACKNOWLEDGEMENTS: Support provided by independent educational grants from: Blue Earth Diagnostics, Inc. Lantheus Medical Imaging

Making Diet Changes Without Extremes; Simplify for Sustainability and Social Connection; Three-Hour Sitting Rule Applies to the Sedentary; Importance of Moving Regularly; Value of Biomarkers vs. Observable Health; Be Cautious with Doctor Visits and Over-Testing; Yoga vs. Weight Training for Bone Strength; Bone Strength Can Improve Quickly with Exercise; Late-Life Exercise Still Effective; Most Supplements Are Unnecessary; Natural Medicine Replaced by Pill-Based Wellness; Fruits, Not Pills, Cured Nutrient Deficiencies Historically; Isolated Powders Lack Traditional Context; Most 'Evidence' for Supplements is Weak #HealthyAging #Longevity #BrainHealth #HealthTalks

We all know our four vital signs and how to take our heart rate, but what about reproductive vital signs? Are there any? YES and they're called reproductive biomarkers. Today's episode lays out the key biomarkers that you can use in your daily life for family planning and health diagnosis (as well as bonus ones that may be more specific to you).Looking for help finding the right method of tracking reproductive biomarkers for you? Our new book, Woven Well: A Christian Woman's Guide for Reproductive Health, Fertility, and Wholeness is here to help! You can pre-order the book now through these links or call your local book store to request it!NOTE: This episode is appropriate for most audiences but does refer to sex education and uses the word 'libido.'SHOW NOTES: **Pre-order Woven Well: A Christian Woman's Guide for Reproductive Health, Fertility, and Wholeness here: https://www.wovenfertility.com/pre-order-woven-wellJoin us for an upcoming Intro Session Ep. 212: Traditional Chinese Medicine explains period blood clots, with guest Emily Keuntz, M.S., L.Ac.Send Us a Text!Support the showOther great ways to connect with Woven Natural Fertility Care: Learn the Creighton Model System with us! Register here!Get our monthly newsletter: Get the updates!Chat about issues of fertility + faith: Substack Follow us on Instagram: @wovenfertilityWatch our episodes on YouTube: @wovenfertilityLove the content? The biggest gift you could give is to click a 5 star review and write why it was so meaningful! This podcast is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician. Always seek the advice of your doctor or other qualified health provider regarding a medical condition. If you think you may have a medical emergency, call 911 or go to the nearest emergency room immediately. Neither Woven nor its staff, nor any contributor to this podcast, makes any representations, exp...

Program notes:0:37 Prehospital resuscitation with whole blood1:37 Compared with blood components2:35 Easier to store 3:19 Azithromycin in wheezing kids4:19 Treated for five days5:26 Name change from PCOS to PMOS6:26 Consensus build7:28 Improved accuracy of pathophysiology8:30 Adjust policy, change international classification9:15 Biomarkers to direct lung cancer screening10:15 Participants from several countries11:15 What are barriers to those with a smoking history12:24 End

Editor's Summary by Preeti Malani, MD, MSJ, and Tracy Lieu, MD, MPH, Deputy Editors of JAMA, the Journal of the American Medical Association, for articles published from May 16-22, 2026.

From the World Congress of Anesthesiologists in Marrakech, TopMedTalk hosts Mike Grocott and Kate Leslie discuss perioperative cardiac risk assessment with Hilary Grocott, Professor and Head of, The Department of Anesthesiology, Pharmacology & Therapeutics (University of British Columbia) and Michelle Chew Professor of Anesthesiology and Intensive Care Medicine at Karolinska Institutet, Stockholm, Sweden, and editor for the British Journal of Anaesthesia. The conversation reviews perioperative cardiac biomarkers, noting abundant prognostic data but limited evidence for biomarker-led management. The discussion emphasizes that elevated troponins can reflect non-cardiac complications (AKI, PE, sepsis) as well as myocardial injury or heart failure, requiring context-specific follow-up pathways. The group highlights NT-proBNP as a specific marker for heart failure and useful for screening and optimization. The podcast then focuses on pulmonary hypertension and failing right ventricle: detect via history, exam, echo, and biomarkers; prioritize preemptive preparation, arterial beat-to-beat monitoring, modest fluids, early vasopressors/inotropes (norepinephrine, low-dose epinephrine), ventilatory optimization, and vigilant, rapid intervention. If you enjoyed this piece there's a fantastic Perioperative Profile with Michelle Chew you can hear here: https://topmedtalk.libsyn.com/perioperative-profiles-professor-michelle-chew-on-seizing-opportunities-in-anaesthesia-research-editing-and-guideline-work -- Join us at Evidence Based Perioperative Medicine (EBPOM) World Congress 2026 in London. Be part of a global conversation as clinicians from around the world gather between 7-9th July at the British Library in London. Three days of evidence-based perioperative medicine, global insights, and expert debate—featuring speakers including Michael Marmot and Ken Rockwood. Register here - https://ebpom.org/product/ebpom-world-congress-2026/

Gina, a perinatal fitness trainer, birth doula, and founder of MamasteFit in North Carolina, explains how exercising during pregnancy improves quality of life during pregnancy and postpartum—not just birth outcomes—while noting prenatal exercise research is still limited. She highlights a 2025/2026 American Journal of Obstetrics and Gynecology systematic review (11 RCTs) finding the strongest biomarker benefits from 12+ week programs done 2–3 times/week at moderate-to-vigorous intensity, including reduced pro-inflammatory markers, improved glucose/insulin regulation (supporting lower gestational diabetes risk), better lipid regulation, and favorable hormone/growth-factor changes linked to placental function and possibly baby brain development. Another 2025 review (9 RCTs, 1,500+ participants) suggests strength training may reduce excessive weight gain, low back/sciatic pain, and improve mood, sleep, fatigue, and well-being. She also cites studies indicating high-intensity lifting and even Valsalva can be well-tolerated with adequate rest and self-monitoring, then outlines MamasteFit's endurance-focused programming (compound lifts, accessory multi-plane work, myofascial slings, and posterior-chain emphasis) and promotes their app/video programs with a discount code.00:00 Why Prenatal Exercise Matters00:46 Meet Gina and MamasteFit01:38 What Research Can Tell Us02:23 Biomarkers and Training Dose05:11 Inflammation and Glucose Control08:05 Lipids Hormones and Baby Brain10:46 Strength Training Quality of Life13:17 Heavy Lifting and Valsalva Safety18:03 Listening to Your Body18:58 How to Program Prenatal Lifting20:54 Movement Variety and Posterior Chain23:04 Programs and Final Takeaways————

Functional Medicine Should Not Overwhelm the Patient More Than the Illness Already Has Episode Overview: Functional medicine has so much potential, but too often it has been reduced to expensive testing, overwhelming supplement protocols, restrictive diets, and long gaps between care. In this episode of Beyond the Biomarkers, Kerri Rachelle opens a larger series on what functional medicine is supposed to be, where it has gone wrong, and why Registered Dietitians are uniquely positioned to bring it back to thoughtful, personalized, nutrition-centered, root-cause care. This episode explores why functional medicine should work alongside conventional medicine, not against it, and why testing, protocols, supplements, and therapeutic diets should always serve the patient — not overwhelm them. What You'll Learn: What Functional Medicine Is Supposed to Be Where Functional Medicine Often Goes Wrong: Why Nutrition Expertise Matters How Testing Should Be Used Responsibly Why Frequency of Care Changes Outcomes Take Action: For Registered Dietitians: If you want to learn how to practice functional medicine with more clinical reasoning, nutrition expertise, accessibility, and integrity, explore ROOTED, our functional medicine training curriculum for RDs: kerrirachelle.com/fellowship For Patients: If you are looking for thoughtful, insurance-based functional nutrition and root-cause support through Registered Dietitians, learn more here: rev0lution.com/nutrition For Employers and Corporate Wellness Leaders: If your current wellness program is not improving employee health, engagement, or outcomes, REV0lution helps organizations support metabolic health, resilience, and performance without simply adding more cost or another unused benefit. Reach out through REV0lution to explore a better model for employee health. Next Episode Preview: This episode begins a larger conversation on Beyond the Biomarkers. In the next episodes, we'll unpack what functional medicine actually is, how conventional and functional medicine can work together, why nutrition must be centered, how testing should be used responsibly, and why practitioner training has to change. Functional medicine should not overwhelm the patient more than the illness already has. It should help people feel understood, supported, and capable of healing one step at a time. Because our health truly is our happiness.

In the second part of this series, Dr. Katie Krulisky and Dr. Cristina Domínguez-González explore the most effective approach to evaluating suspected mitochondrial disease. Show citation: Bermejo-Guerrero L, Restrepo-Vera JL, Martin-Jimenez P, et al. Clinical Heterogeneity and Candidate Biomarkers in POLG-Related Mitochondrial Disease. Neurol Genet. 2026;12(2):e200365. Published 2026 Mar 10. doi:10.1212/NXG.0000000000200365  Show transcript:  Dr. Katie Krulisky: This is The Neurology Minute. This is the second part of our series. I'm Katie Krulisky from the University of Utah and I'm here with Cristina Domínguez-González from the 12th of October University Hospital and its affiliated health research institute in Madrid, Spain. We've just recorded a full podcast on our paper, Clinical Heterogeneity and Candidate Biomarkers in POLG-related Mitochondrial Disease, which has been published in Neurology Genetics. Cristina, for The Minute, what's the most practical way to work up suspected mitochondrial disease today? Dr. Cristina Domínguez-González:  In practice, everything starts with the clinical picture. Recognizing the pattern, whether it's a combination of features or a more subtle isolated presentation, is what should first raise suspicion. From there, you decide the next step. Targeted genetic testing if the phenotype is well-defined, grow their sequencing if it is less clear or more complex. Biomarkers can also be very helpful. GDF15, Growth Differentiation Factor 15, is markedly elevated in many mitochondrial diseases and can support the suspicion. In myopathies in particular, it is especially useful because of its high negative predictive value helping to rule out a mitochondrial cause when levels are not elevated. And finally, muscle biopsy still has a role. It can provide important information in selected cases, particularly in adults or when genetic results are inconclusive, both for diagnosis and also to guide further studies. Dr. Katie Krulisky: Thank you. That's super helpful. And for more on mitochondrial diseases and POLG-related disorders, have a listen to the full neurology podcast. Again, I'm Katie Krulisky from the University of Utah with Cristina Domínguez-González  from the 12th of October University Hospital and its affiliated health research institute in Madrid, Spain.  

What if your genes are not your destiny, but a set of clues your body has been giving you all along? In this episode, Dr. Taz sits down with Dr. Florence Comite, endocrinologist, clinician scientist, longevity expert, and author of Invincible: Defy Your Genetic Destiny to Live Better, Longer, to explore how biomarkers, genetics, hormones, sleep, metabolism, and family history shape the way we age.In this episode, Dr. Comite explains why longevity is not just about biohacking, supplements, peptides, or the latest wellness trend. Instead, she shares why true healthspan begins with understanding your own body, your own patterns, and your own family story. She explains how changes in blood sugar, fasting insulin, free testosterone, cholesterol risk ratio, sleep quality, muscle, and metabolism can reveal early signs of disease risk long before symptoms fully appear.Dr. Taz and Dr. Comite discuss why “normal” lab ranges are not always the same as optimal health, why some people begin showing signs of metabolic disease decades earlier than expected, and how family history can act as a powerful roadmap for prevention. They also explore how genetics, lifestyle, hormones, wearables, continuous glucose monitoring, sleep, movement, protein, and personalized medicine may help people change the trajectory of their future health.If you're listening to this and thinking, “I know something is off in my body, but I don't know where to start,” join the Circle here:

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Cash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejects1. Patel, A. K., et al. *Physiology, Sleep Stages*. StatPearls / NCBI Bookshelf, 2024.2. Jensen, O., & Mazaheri, A. “Shaping Functional Architecture by Oscillatory Alpha Activity: Gating by Inhibition.” *Frontiers in Human Neuroscience*, 2010.3. Cavanagh, J. F., & Shackman, A. J. “Frontal Midline Theta Reflects Anxiety and Cognitive Control: Meta-Analytic Evidence.” *Journal of Physiology-Paris*, 2015.4. Axmacher, N., et al. “Cross-Frequency Coupling Supports Multi-Item Working Memory in the Human Hippocampus.” *PNAS*, 2010.5. Lacaux, C., et al. “Sleep Onset Is a Creative Sweet Spot.” *Science Advances*, 2021.6. Horowitz, A. H., et al. “Targeted Dream Incubation at Sleep Onset Increases Post-Sleep Creative Performance.” *Scientific Reports*, 2023.7. Caporro, M., et al. “Functional MRI of Sleep Spindles and K-Complexes.” *Clinical Neurophysiology*, 2012.8. Ng, T., et al. “Bayesian Meta-Analysis Reveals the Mechanistic Role of Slow Oscillation-Spindle Coupling in Sleep-Dependent Memory Consolidation.” *eLife*, 2025.9. Datta, K., et al. “Electrophysiological Evidence of Local Sleep During Yoga Nidra Practice in Young Male Volunteers.” *Frontiers in Neurology*, 2022.10. Jensen, M. P., et al. “Brain Oscillations, Hypnosis, and Hypnotizability.” *American Journal of Clinical Hypnosis*, 2015.11. Huels, E. R., et al. “Neural Correlates of the Shamanic State of Consciousness.” *Frontiers in Human Neuroscience*, 2021.12. Ingendoh, R. M., et al. “Binaural Beats to Entrain the Brain? A Systematic Review...” *PLOS ONE*, 2023.13. Páez, A., et al. “Sleep Spindles and Slow Oscillations Predict Cognition and Biomarkers of Neurodegeneration in Mild to Moderate Alzheimer's Disease.” *Alzheimer's & Dementia*, 2025.14. Askitopoulou, H. “Sleep and Dreams: From Myth to Medicine in Ancient Greece.” *Journal of Anesthesia History*, 2015.15. Pavli, A. “Asclepieia in Ancient Greece: Pilgrimage and Healing.” *Journal of Integrative Medicine and Research*, 2024.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. Now let me introduce the rest of the panel and guests.

In part one of this series, Dr. Katie Krulisky and Dr. Cristina Domínguez-González discuss when a neurologist should start thinking about mitochondrial disease.  Show citation: Bermejo-Guerrero L, Restrepo-Vera JL, Martin-Jimenez P, et al. Clinical Heterogeneity and Candidate Biomarkers in POLG-Related Mitochondrial Disease. Neurol Genet. 2026;12(2):e200365. Published 2026 Mar 10. doi:10.1212/NXG.0000000000200365  Show transcript:  Dr. Katie Krulisky: This is The Neurology Minute, and this will be a two-part series. I've had the pleasure of speaking with Cristina Domínguez-González from the 12th of October University Hospital and its affiliated Health Research Institute in Madrid, Spain. I'm Katie Krulisky from the University of Utah. We've just recorded a full podcast on our paper, Clinical Heterogeneity and Candidate Biomarkers and POLG-related Mitochondrial Disease, which has been published in Neurology Genetics. So for our first minute, Cristina, when should a neurologist start thinking about mitochondrial disease? Dr. Cristina Domínguez-González: Mitochondrial diseases are among the most common inherited neurological disorders. Think of them whenever you see compatible features like ptosis ophthalmoplegia, polyneuropathy, ataxia or myopathy, especially when they occur in combination. But even when these features appear in isolation, mitochondrial disease should still be part of the differential. This is particularly important because many patients do not present with a full classical picture, especially in early the disease course. In practice, this means maintaining a low threshold to consider mitochondrial disease, even in a typical presentations. Dr. Katie Krulisky: Thank you so much. And for more information on mitochondrial disease and POLG-related disorders, do listen to the full neurology podcast. Again, I'm Katie Krulisky from the University of Utah with Cristina Domínguez-González from the 12th of October University Hospital and its affiliated Health Research Institute in Madrid, Spain.   

Dr. Katie Krulisky talks with Dr. Cristina Domínguez-González about the complexities of mitochondrial disease, including diagnosis, biomarkers, and recent research on POLG-related disorders.  Read the related article in Neurology® Genetics.  Disclosures can be found at Neurology.org.

Join primary care faculty Gary Ferenchick, Kate Rowland, Henry Barry and Mark Ebell as they discuss 4 important new studies: the value (?) Of biomarkers in cognitive impairment, toilet training, bleeding risk with apixaban versus rivaroxaban for VTE, and diagnosing volume overload in adults  from the JAMA Rational Clinical Exam series.

The number one side effect of comfort is chronic disease, and we're more comfortable than any generation in human history. In this episode, Dr. Clay Moss and I unpack the simple, foundational shifts that produced life-changing results in a 7-day in-patient metabolic rehabilitation protocol: full elimination diet, sleep hygiene, intentional movement, stress management, and community connection. No biohacking gadgets required. Just a return to the basics, your biology was built for. CLICK HERE TO BECOME GARY'S VIP!: https://bit.ly/4ai0Xwg Listen to "Off Label with Dr. Clay Moss" on all your favorite platforms! YouTube: https://bit.ly/4defyfj  Spotify: https://bit.ly/4t5CbY7  Connect with Dr. Clay Moss Website: https://bit.ly/4cGbCE7  YouTube: https://bit.ly/423HwEo  Instagram: https://bit.ly/4mZqjoZ  Facebook: https://bit.ly/4teExEk  TikTok: https://bit.ly/423KkkU  X: https://bit.ly/3R88atg  LinkedIn: https://bit.ly/4cVVAVx  Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij  AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD  AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze  BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa  BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV  COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp  CYMBIOTIKA: "ULTIMATE10" FOR 10% OFF: https://bit.ly/4tjyluP  GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk  GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9  GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC   H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg  HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S  PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn  SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V  WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW  Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 ​Intro of Show 04:18 Metabolic Syndrome Definition 06:00 Dr. Clay Moss's Medical Journey 16:05 Biomarkers to Start 23:14 Functional Medicine Program 28:25 Stress Management Protocols 21:35 GLP-1: Pros and Cons 37:21 Future of Peptides 41:42 When Should People Take Peptides, GLP-1? 47:54 Muscle as Our Metabolic Currency 53:14 Female Hormone Therapy Benefits 58:04 Dr. Clay Moss's Mission-Vision 1:03:38 How to Improve Sleep Hygiene 1:08:08 Connect with Dr. Moss 1:08:40 What does it mean to you to be an Ultimate Human? Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered.  Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the WHOOP Podcast How To Series, WHOOP Global Head of Human Performance and Principal Scientist, Dr. Kristen Holmes, sits down with renowned longevity expert, Dr. Darshan Shah, to break down how to maximize longevity. The episode focuses on what truly drives healthspan, drawing from Dr. Shah's own experience as a trauma surgeon. Dr. Shah explains why most chronic diseases are preventable and reversible and why lasting change comes from mastering the fundamentals: sleep quality, daily movement, nutrition, stress management, and consistent data tracking. The conversation explores key biomarkers, the dangers of sedentary living, the role of toxins and environment, and the importance of habit formation, purpose, and emotional health. Together, Dr. Shah and Dr. Holmes reframe longevity not as living longer, but as living better— extending vitality, resilience, and performance throughout life.(00:47) Intro to Dr. Darshan Shah, Longevity Expert(01:14) How Chronic Illness Impacted Dr. Shah Firsthand(06:15) Dr. Shah: From Trauma Surgeon to Longevity Focused Lifestyle(09:30) Building Next Health: Dr. Shah's Impact on the Longevity World(13:10) Biggest Barrier For Patients: What Trends Dr. Shah Is Seeing (19:50) The Influence of a Morning Routine on Health and Longevity(21:36) Looking At The Biggest Game Changer: Movement Throughout The Day(24:26) Eliminating The “All or Nothing” Mentality(28:23) Beyond Sedentary Behavior: Habits Declining Longevity(37:18) Best Biomarkers Promoting Longevity(48:04) Optimization Beyond Nutrition, Sleep, and Exercise (Advanced Advice)(52:28) Combatting Trauma and Understanding The Nervous System(56:18) Dr. Shah's Wellness Wheel: 12 Aspects of Health(58:52) Technological Development In Health and Longevity(59:43) Menopause and Longevity: How Women Can Mitigate Symptoms(01:08:18) Policy Changes That Will Aid Health and LongevityFollow Dr. Darshan ShahInstagram WebsiteDr. Shah's Guide to Minimizing Toxic ExposureDr. Shah's Guide to Biomarkers  Support the showFollow WHOOP:Sign up for WHOOP Advanced LabsTrial WHOOP for Freewww.whoop.comInstagramTikTokYouTubeXFacebookLinkedInFollow Will Ahmed:InstagramXLinkedInFollow Kristen Holmes:InstagramLinkedInFollow Emily Capodilupo:LinkedIn 

“The awareness of how lifestyle, diet, and exercise affect us is mind-blowing.” Dr. Giovanni Campanile and Dr. Sandra Cammarata are the founders of CorAeon, the only functional medicine practice founded and led by a husband-and-wife team. Campanile is a Harvard-trained functional cardiologist, Associate Professor of Medicine at Rutgers, New Jersey Medical School, and former cardiologist for the President of the United States, George H.W. Bush. Cammarata is a Tufts-trained functional psychiatrist with 36 years of experience and multiple Castle Connolly Top Doctor honors. Together, they treat cardiovascular health and mental well-being as one inseparable system. They are co-authors of The Sicilian Secret Diet Plan and hosts of the podcast The Rest is Health. 00:00 - The mind-body approach to heart health 03:01 - How relationships predict lifespan 05:18 - The Monday morning heart attack 09:13 - Where healthy people get tripped up 13:02 - Visceral fat & body composition testing 15:28 - Biomarkers beyond cholesterol 23:25 - The problem with a zero CAC score 25:09 - Medications for heart disease risk 28:22 - When stress is the real driver 31:46 - EXO Mind & magnetic brain stimulation 35:34 - The problems with traditional cardiology 41:00 - The benefits of sauna therapy 44:46 - The hidden epidemic: insulin resistance 47:57 - The future of heart health Referenced in the episode:  Harvard longevity study: https://www.adultdevelopmentstudy.org/  This podcast is sponsored by CorAeon, the only functional medicine practice created by a functional cardiologist and functional psychiatrist team for a true mind-body approach. Learn more at coraeon.com.  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Full Show Notes: https://bengreenfieldlife.com/trupodcast In this episode with repeat guest Dr. Matt Dawson, you’ll discover how epigenetic testing analyzes DNA methylation to reveal how fast you’re biologically aging, what’s driving your health, and your risk for disease. You’ll explore how these signals can detect chronic disease risk earlier than traditional labs, and how TruDiagnostic built the TruHealth Test by analyzing ~1,000 biomarkers to pinpoint the most meaningful health indicators. We also break down the TruAge Test, covering biological age, pace of aging, and organ-specific aging, plus insights from my own results. We discuss how AI and large language models (LLMs) identify which interventions actually improve specific biomarkers, and what truly moves the needle for longevity, from caloric restriction and GLP-1 drugs to the often-overlooked impact of relationships, stress, and recovery.

In this episode of the WHOOP Podcast, WHOOP Founder and CEO Will Ahmed sits down with Quest Diagnostics CEO Jim Davis to discuss the partnership behind WHOOP Advanced Labs. Will and Jim discuss how combining blood biomarkers with continuous physiological data is reshaping consumer health. Will and Jim explore how trends in metrics like cholesterol, glucose, sleep, and recovery can drive more personalized, actionable insights and help shift healthcare from reactive to preventative. Jim shares his personal approach to health tracking, Quest's vision for democratizing lab testing, and leadership lessons from running a 50,000+ employee organization. Jim gets candid about his “obsession” with his WHOOP data and his advice for managing stress and staying focused on long-term health habits.Sign up for WHOOP Advanced Labs, available now in the WHOOP app. Learn more about WHOOP Advanced Labs here.(01:12) Jim Davis on the WHOOP x Quest Diagnostics Partnership(03:06) What WHOOP Members Can Expect From WHOOP Advanced Labs(07:10) Action From Insight: Understanding Trends To Optimize Your Health(12:27) How Frequently Should You Check Your Biomarkers? (13:25) Building The Tech: The Challenges of Health Innovation(18:10) Establishing Wellness Trends: Why Annual Bloodwork Matters(20:41) Lifestyle Factors That Can Cause Issues In Health & Biomarkers(22:23) Growing The Business: Jim's Vision For The Future of Quest(30:25) Do We Need Supplements?: What Your Bloodwork Says About Supplementation(32:37) Jim Davis on Understanding Blood Biomarkers & Using WHOOP To Form Healthy Habits(37:00) Jim's Lessons on Operational ExcellenceSupport the showFollow WHOOP:Sign up for WHOOP Advanced LabsTrial WHOOP for Freewww.whoop.comInstagramTikTokYouTubeXFacebookLinkedInFollow Will Ahmed:InstagramXLinkedInFollow Kristen Holmes:InstagramLinkedInFollow Emily Capodilupo:LinkedIn 

In this episode, we explore a groundbreaking development in the diagnosis of chronic fatigue syndrome (CFS/ME) — a condition that affects millions worldwide, yet remains notoriously difficult to identify… Joining the podcast to discuss this topic are Alexandre Akoulitchev and Dmitry Pshezhetskiy, who break down a novel blood test designed to detect biological signatures associated with chronic fatigue. Their work centers on cutting-edge epigenetic science and biomarker discovery, offering new possibilities for more objective and earlier diagnosis of complex, hard-to-measure conditions. Hit play to discover: How a blood-based biomarker test may help identify chronic fatigue syndrome. The role of epigenetics in understanding complex, "invisible" illnesses. The four key symptoms of ME/CFS, and why it's so difficult to diagnose. How inflammation signals can contribute to chronic fatigue. Alexandre Akoulitchev is a molecular biologist specializing in genome regulation and chromatin architecture. He is a cofounder of Oxford BioDynamics and the creator of its EpiSwitch biomarker platform. He earned his PhD in cell biology from University College London. Dmitry Pshezhetskiy is a Professorial Research Fellow at Norwich Medical School and an academic clinician focused on cancer biology and therapeutic research. He completed his academic training at Moscow State University, Montréal institutions, and leading research centers in France, building a strong background in molecular medicine and translational research. You can connect with Alexandre Akoulitchev here and Dmitry Pshezhetskiy here!