Arkansas Researchers in Medicine (ARM)

The Voth laboratory studies Coxiella burnetii, an obligate intracellular bacterial pathogen that causes human Q fever. http://mbim.uams.edu/Daniel_Voth

Dr. Compadre has extensive research experience, on the study of bioactive compounds from natural origin, and on the use of molecular modeling in drug design and structure-activity studies, with over 70 publications, 9 US patents related to the development of bioactive compounds, and one FDA approved antimicrobial technology. http://pharmcollege.uams.edu/departments-units/pharmaceutical-sciences/pharmaceutical-sciences-faculty/drccompadre/

Charles O'Brien, Ph.D., is a Professor and a CAVHS Research Scientist; and the director of the UAMS transgenic mouse core facility. He is a molecular biologist trained at Oklahoma and Yale Universities. He joined the Center in 1994 and his work focuses on the molecular control osteoclastogenesis and bone turnover in health and disease. Dr. O'Brien is the Director of the UAMS Transgenic Facility.

We are interested in the analysis of structure and function of biological macromolecules using crystallographic techniques. Our research comprises three main areas: (i) Bacterial signaling (ii) Interactions of von Willebrand Factor and thrombin with platelet receptors (iii) Interactions of methamphetamine and other drugs of abuse with therapeutic antibodies. http://physiology.uams.edu/faculty/kottayil-varughese/

In my laboratory we study the function of novel genes, in particular those involved in bone formation, development, homeostasis and disease. We utilize the power of mouse gene targeting and conditional gene-inactivation techniques to generate ubiquitous or tissue-specific mutations in the mouse. With the use of cell biology, biochemistry, cell microscopy and genetic approaches we characterize the phenotype of these mice to understand the underlying gene function. The objective is to learn from the animal model and make correlations with relevant aspects of human disease and hence gain mechanistic insights of biological function. rmorello@uams.edu

http://pharmtox.uams.edu/gottschall