Podcasts about Plasmodium

TWiP explains a study that carries out selection of Plasmodium falciparum in the presence of inhibitors to identify determinants of drug resistance, and a paleoparasitological analysis of a 5th–16th c. CE latrine. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Naegleria fowleri acquired at splash pad (MMWR) Determinants of P. falciparum drug resistance (Science) Paleoparasitological analysis of 5th–16th c. CE latrine (Parasitol) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #77 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/13/25 – 3/26/25. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Food is medicine for human immunodeficiency virus: improved health and hospitalizations in the changing health through food support (chefs-hiv) pragmatic randomized trial (JID) The epidemiology and burden of human parainfluenza virus hospitalizations in u.s. children (Journal of the Pediatric Infectious Diseases Society) Bacterial Epidemiology and outcomes of bloodstream infections in patients in a burns intensive care unit: an eight-year retrospective study(OFID) Prophylactic vancomycin in the primary prevention of clostridium difficile in allogeneic stem cell transplant(Transplant Infectious Disease) Incidence of scrub typhus in rural south India (NEJM) Antibiotic treatment for 7 versus 14 days in patients with bloodstream infections(NEJM) Blood Culture–Negative Endocarditis(Journal of the American Heart Association) Brucella suis Infection in Cardiac Implantable Device of Man Exposed to Feral Swine Meat, Florida, USA (CDC Emerging Infectious Diseases) Hyperbilirubinemia at hospitalization predicts nosocomial infection in decompensated cirrhosis (Hepatology Communicatons) Fungal The Last of US Season 2 (YouTube) Fungal Infections in People Who Use Drugs (OFID) IDSA 2025 guideline update on the treatment of asymptomatic histoplasma pulmonary nodules (histoplasmomas) and mild or moderate acute pulmonary histoplasmosis in adults, children, and pregnant people(IDSA: Infectisous Disease Society of America) Changing trends in the sources and volumes of clinical cultures with Candida auris at a large health system, 2019-2023 (American Journal of Infection Control) Diagnostic test accuracy of the Fungitell serum (1→3)-β-D-glucan assay for the diagnosis of Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis (CMI: Clinical Microbiology and Infection) Parasitic Impact of Strongyloides stercoralis Coinfection on Disease Severity and Treatment Outcomes in Pulmonary Tuberculosis (OFID) Hematology thin smears perform equally to parasitology thick and thin blood smears for the diagnosis of Plasmodium and Babesia infections in a low prevalence setting (Journal of Clinical Microbiology) Notes from the Field: Rhodesiense Human African Trypanosomiasis (Sleeping Sickness) in a Traveler Returning from Zimbabwe — United States, August 2024 (CDC: MMWR) Miscellaneous The history of phage therapy LANCET: Infectious Diseases) Silence=death redux: infectious diseases, public health, and the imperative to resist (CID) Silence = Death, 1990(David Wojnarowicz Foundation) SILENCE=DEATH (B200KLYN Museaum) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

Today, we're venturing into a topic that many of us might not think about — parasite and worm infections. These unseen invaders can wreak havoc on your health, yet often go unnoticed for a long time. And, despite all the supplements and peptide therapies we might be using to optimize our health, we may still be missing something very important: a potential parasite or worm infection. In this episode, we'll explore the signs and symptoms of these infections, how you can acquire them, and why we should consider them even if we're doing everything "right" in terms of diet and wellness. Let's get into it! First things first—what are parasites and worms, and how are they different?. A parasite is any organism that lives on or inside another organism, known as a host, and benefits at the host's expense. Parasites can be microscopic or visible to the naked eye. Parasites can take many forms, including: Protozoa (single-celled organisms like Plasmodium that causes malaria) Helminths (worms like roundworms, tapeworms, and flatworms) Ectoparasites (organisms like fleas, lice, or ticks that live on the host's skin or surface). They usually don't infect other parts of your body. When people refer to worm infections, they are typically talking about helminth infections. Helminths are a specific type of parasite, and they are multicellular organisms that can be categorized into three main types: Roundworms (e.g., hookworms, pinworms, and threadworms) Tapeworms Flukes (flatworms) So, all worm infections are parasitic, but not all parasites are worms.   What are the symptoms of parasitic infections?   So, how can you tell if you have a parasite/protozoa or a worm infection? Let's talk about signs and symptoms. Signs of a parasite infection can be a bit tricky because they often mimic other illnesses or conditions. You might experience: Diarrhea (sometimes with blood or mucus) Stomach cramps or bloating Fatigue Unexplained weight loss Skin rashes or itching Nausea or vomiting Fever Visible worms in stools or around the anus Itchy anus (especially with pinworm infections) Coughing or chest pain (in the case of certain lung-dwelling worms) Parasites can also affect your mood and mental health, causing things like anxiety or brain fog due to the toxins they release in your body. While some worm infections can be obvious, others may linger for years without being detected, causing slow, gradual damage to the body. How do you get parasitic infections? So, how do we acquire these infections? There are several ways you can pick up a parasite or worm, and it often depends on where you live, what you eat, and what activities you engage in. Let's break it down: Traveling: Traveling to areas with poor sanitation increases the risk of contracting Giardia and Cryptosporidium, two protozoan parasites commonly found in contaminated water or food. These parasites can lead to traveler's diarrhea, causing symptoms like severe stomach cramps, bloating, nausea, and frequent watery diarrhea. In some cases, infections can lead to dehydration and fatigue, making it important to take precautions like drinking bottled water and avoiding undercooked food while traveling.   Eating undercooked meat or fish: Undercooked pork or fish can harbor parasitic larvae, such as Trichinella in pork and Anisakis (Anne-e-sakis) in fish. When consumed, these parasites can survive in the digestive system and begin to infect the body. For example, Trichinella can cause trichinosis, leading to symptoms like muscle pain and fever, while Anisakis can cause abdominal pain and nausea. Properly cooking these meats to safe temperatures can kill the parasites and prevent infection. Contaminated Soil: Certain parasites, like hookworms, can enter your body through small breaks or pores in the skin if you walk barefoot on contaminated soil. Areas where you are most likely to encounter hookworms in soil include Southeast Asia, Sub-Saharan Africa, Latin America (especially Central and South America), Caribbean Islands, and Southern United States (especially in areas with poor sanitation). Insects: Mosquitoes and other insects can transmit diseases caused by parasites, such as Plasmodium, the parasite responsible for malaria. Similarly, ticks can carry parasites like Babesia (buh-bee-zee-ah), which causes babesiosis (buh-bee-zee-OH-sis) Close contact: Some parasites are spread through human-to-human contact, especially in crowded or unsanitary conditions (e.g., schools, daycares, campgrounds, public restrooms, and nursing homes). For example, pinworms can be contracted by anyone, though they are most often seen in children. They are highly contagious, and you can acquire them through contact with contaminated surfaces or even from sharing bedding. How are parasitic infections diagnosed? Healthcare providers look for the parasites themselves or signs of them, such as their eggs, in your body fluids or tissues. To check for parasites, your provider might take samples from different areas, including: Your stool  Blood Skin or any affected tissue Phlegm (sputum) Fluid around your brain and spinal cord (CNS fluid) In some cases, your provider might also use imaging tests like X-rays, MRI, or CT scans to help diagnose a parasitic infection, depending on what symptoms you're experiencing. Now, this all ties into a bigger picture. Many people are investing heavily in their health these days—through supplements, peptide therapies, and cutting-edge wellness routines. And while these are all beneficial, they can't always protect us from hidden invaders like parasites and worms. What's more, many of the symptoms of a parasite or worm infection can mimic other conditions, and because we often don't think about these infections, they can go undiagnosed for years.  If you're dealing with ongoing digestive issues, fatigue, skin problems, or even unexplained brain fog, it might be time to consider that a parasite or worm infection could be behind it—especially if you've recently traveled.   Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week. We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey.  Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Researchers search for ways to predict antimalarial drug resistance and identify more effective drug combinations. Transcript The front-line treatment for malaria is typically a combination of drugs called artemisinin-based combination therapy. Resistance to treatment has already been reported in mild cases of malaria, but now, for the first time, it's also being reported in severe cases of malaria. Severe malaria cases are more likely to end in a fatal outcome, so drug resistance in these scenarios poses a risk to human life. To try and stay one step ahead of resistance, researchers tested compounds and combed through publications to identify 118 compounds active against over 700 parasite clones to see how the parasites evolve under pressure, and to identify mutations in the parasite genome likely to be associated with drug resistance. They confirmed that Plasmodium falciparum – the deadliest and most prevalent species of the malaria parasite – evolves relatively easily, with mutations that affect the drug's mechanism of action and which move through the population. The hope is that this dataset of drug resistance markers could provide an ‘early warning system' – to predict drug resistance in the field and to identify a more effective drug combination. Source Artemisinin Partial Resistance in Ugandan Children With Complicated Malaria (JAMA) Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance (Science)   About The Podcast The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.  

Nels and Vincent review the identification of a novel virus associated with the pathogen Plasmodium knowlsei and which is part part of a diverse and unclassified viral taxon. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Virus associated with P. knowlsei (bioRxiv) Timestamps by Jolene Science Picks Nels – The peace of wild things, poem by Wendell Berry Vincent – All Life on Earth Today Descended From a Single Cell. Meet LUCA Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune memory diversity in human upper airway (Nature) How Plasmodium infection promotes B cell cancers (Cell) Time stamps by Jolene. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Today, how DNA from a single patient in Ethiopia can shed light on the big picture of malaria. Why is Plasmodium vivax significant in malaria research, especially in Ethiopia? How does genomic sequencing contribute to understanding and controlling malaria? How are advances in sequencing technology influencing malaria research? With Jane Carlton, Delenasaw Yewhalaw, and Francisco Callejas Hernandez About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

'Comparative genomics' helps identify genes that can serve as targets for future drugs and vaccines. Transcript Not all parasites are alike. Genetic mutations mean that malaria parasites evolve differently in different regions – and even within the same region. One species thought to be particularly genetically diverse is Plasmodium vivax. It's the second most common species of malaria, found in South East Asia, South America, and some parts of Africa. In Ethiopia, 20% of malaria cases are thought to be caused by P. vivax. In a new paper, scientists made a ‘reference genome' from a sample of P. vivax in Ethiopia. They collected blood from an infected patient, extracted the DNA, and ‘read' its fragments to form the parasite genome. This allows scientists to compare P. vivax samples across regions – and understand their similarities and differences. Importantly, this study of ‘comparative genomics' ie comparing genomes will help identify the genes that stay the same – the conserved genes – and those which are different - the unique genes -which could serve as targets for future drugs and vaccines. Source Assembled genome of an Ethiopian Plasmodium vivax isolate generated using GridION long-read technology About The Podcast The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

In this episode of the Epigenetics Podcast, we talked with Karine Le Roch from the University of California at Riverside about her work on malaria chromatin structure and its transcriptional regulation. In this Interview Dr. Le Roch discusses her investigation of post-transcriptional controls and nucleosome positioning in Plasmodium falciparum, employing next-generation sequencing and chromatin profiling methods. Karin emphasizes how these methodologies contribute to a comprehensive understanding of gene regulation beyond mere transcription initiation, emphasizing the significance of mRNA binding proteins and their role in stabilizing gene transcripts for translation. This exploration of the interaction between chromatin structure, transcriptional dynamics, and post-transcriptional regulation reveals a multidimensional perspective of gene expression. Transitioning to her lab's focus on high-throughput genomic technologies, we discuss how Karin and her team are uncovering conserved and species-specific genomic organization principles within various Plasmodium species. By generating 3D genomic models through Hi-C experiments, she describes how they have identified patterns that underline the parasite's immune evasion strategies. In particular, we learn how genes involved in antigenic variation are controlled through intricate epigenetic mechanisms, illuminating the pathways that allow these parasites to elude host immune responses.   References Le Roch, K. G., Zhou, Y., Blair, P. L., Grainger, M., Moch, J. K., Haynes, J. D., De La Vega, P., Holder, A. A., Batalov, S., Carucci, D. J., & Winzeler, E. A. (2003). Discovery of gene function by expression profiling of the malaria parasite life cycle. Science (New York, N.Y.), 301(5639), 1503–1508. https://doi.org/10.1126/science.1087025 Ponts, N., Harris, E. Y., Prudhomme, J., Wick, I., Eckhardt-Ludka, C., Hicks, G. R., Hardiman, G., Lonardi, S., & Le Roch, K. G. (2010). Nucleosome landscape and control of transcription in the human malaria parasite. Genome research, 20(2), 228–238. https://doi.org/10.1101/gr.101063.109 Bunnik, E. M., Cook, K. B., Varoquaux, N., Batugedara, G., Prudhomme, J., Cort, A., Shi, L., Andolina, C., Ross, L. S., Brady, D., Fidock, D. A., Nosten, F., Tewari, R., Sinnis, P., Ay, F., Vert, J. P., Noble, W. S., & Le Roch, K. G. (2018). Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages. Nature communications, 9(1), 1910. https://doi.org/10.1038/s41467-018-04295-5   Related Episodes Epigenetics in Human Malaria Parasites (Elena Gómez-Diaz)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Plasmodium falciparum malaria, the most severe form of this disease, usually occurs in persons traveling without prophylaxis or with inadequate prophylaxis. Most cases of malaria occur in missionaries, long-term expatriates, and immigrants who have returned to the country of their origin to visit friends and family (VFR travelers). Failure to take adequate malaria prophylaxis may occur for economic reasons or due to the mistaken belief that prolonged residence in high risk areas leads to immunity. Practical prevention strategies and the self treatment of malaria are discussed. Session recorded on Friday, November 10th during Session Block #4 at 2:30 PM EST ; speaker: Gregory Juckett Session webpage: https://www.medicalmissions.com/events/gmhc-2023/sessions/malaria-prevention-and-treatment-in-missionaries

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Rafael Polidoro to talk about his career, the research of his laboratory on how the gut microbiome modulates the local and systemic immune responses during infections. Hosts: Cindy Leifer and Steph Langel Guest: Rafael Polidoro Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Content in this podcast should not be construed as medical advice.

Sean Murphy joins TWiP to discuss his career and the work of his laboratory to assess the daily natural history of asymptomatic Plasmodium infections in adults and older children in Katakwi, Uganda. Hosts: Vincent Racaniello, Dickson Despommier and Christina Naula Guest: Sean Murphy Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Daily natural history of Plasmodium infections (Lancet Microbe) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

What does the body of evidence say on malaria? Your favourite travel destination may be a malaria hot zone: we discuss how to prepare. Plus: a strange FDA application to use MDMA to treat PTSD, and have statins been overprescribed?   A Block: Malaria (0:58) History; the parasite's life cycle; how many people are affected by malaria; symptoms; how to diagnose it; how to treat it; prevention. B Block: Ecstasy for PTSD (35:46) An advisory committee for the FDA has raised many concerns about a company's application to use MDMA (ecstasy, molly) as part of psychotherapy for post-traumatic stress disorder. C Block: Statin Overprescription (46:08) A new risk calculator is classifying fewer people as needing statins. * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl * Assistant researcher: Aigul Zaripova To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/. To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE Patrons get a bonus show on Patreon called “Digressions”! Check it out! Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   References: 1) WHO fact sheet on malaria: https://www.who.int/news-room/fact-sheets/detail/malaria History of malaria: 2) https://doi.org/10.3390/ijerph7020675 3) https://doi.org/10.1007/s11230-004-6354-6 4) DOI: 10.1111/j.1365-2141.2008.07085.x 5) https://doi.org/10.1179/135100003225002952 6) https://doi.org/10.1038/hdy.2011.16 7) doi: 10.1038/s41598-018-19554-0  8) https://www.ncbi.nlm.nih.gov/books/NBK215638/    9) Plasmodium parasite life cycle: https://www.cdc.gov/dpdx/malaria/index.html    Malaria epidemiology: 10) https://www.canada.ca/en/public-health/services/catmat/canadian-recommendations-prevention-treatment-malaria/chapter-1-introduction.html  11) https://www.who.int/news-room/fact-sheets/detail/malaria  12) https://apps.who.int/malaria/maps/threats/# 13) https://www.who.int/publications/i/item/9789240086173  14) DOI: 10.15585/mmwr.mm7236a1   15) https://emergency.cdc.gov/han/2023/han00496.asp  16) https://www.canada.ca/en/public-health/services/catmat/appendix-1-malaria-risk-recommended-chemoprophylaxis-geographic-area.html    How to diagnose malaria: 17) https://www.cdc.gov/dpdx/resources/pdf/benchAids/malaria/Pfalciparum_benchaidV2.pdf  18) https://www.cdc.gov/dpdx/resources/pdf/benchAids/malaria/Pvivax_benchaidV2.pdf  19) https://www.cdc.gov/dpdx/resources/pdf/benchAids/malaria/Povale_benchaidV2.pdf  20) https://www.cdc.gov/dpdx/resources/pdf/benchAids/malaria/Pmalariae_benchaidV2.pdf    How to prevent malaria: 21) https://www.who.int/groups/vector-control-advisory-group/summary-of-new-interventions-for-vector-control/lethal-house-lures  22) DOI: 10.1016/S0140-6736(24)00004-7 23) https://www.bbc.com/news/world-africa-68037008 24) DOI: 10.1056/NEJMoa2026330 25) DOI: 10.1016/S1473-3099(23)00368-7 26) DOI: https://doi.org/10.1016/S1473-3099(22)00442-X   27) Dr. Andrea Love's article about DEET and insect repellents for Immunologic: https://immunologic.substack.com/p/essential-oils-are-not-chemical-free?publication_id=2109759&post_id=145493032&isFreemail=true&r=5o22t 28) Ada McVean's article about insect repellents for the McGill OSS: https://www.mcgill.ca/oss/article/health-technology/why-mosquitos-bite-you-and-how-make-them-stop 29) FDA advisers vote against medical use of ecstasy: https://www.science.org/content/article/fda-advisory-panel-rejects-mdma-ptsd-treatment 30) Elizabeth Conney's STAT article on new cardiovascular risk calculator for statin prescriptions: https://www.statnews.com/2024/06/10/cardiovascular-disease-statins-aha-guidelines/   It's Not Twitter But It'll Do: 1) Jonathan's interview on the Rethinking Wellness podcast: https://rethinkingwellness.substack.com/p/why-you-probably-dont-have-a-leaky

A poorly studied malaria protein could serve as a key drug target to help combat the growing problem of resistance. Transcript A poorly studied malaria protein – Plasmodium falciparum histone deacetylase 1 – could serve as a key drug target to help combat the growing problem of resistance. The protein helps regulate the ‘intraerythrocytic' stage of the parasite: a 48-hour cycle in which the parasite invades, replicates, and bursts free from red blood cells, causing disease symptoms. By making this protein fluorescent, researchers found that it is associated with a range of major biological functions that help the parasite progress through this stage, particularly during the ‘trophozoite' (or mature) stage. When PfHDAC1 was overexpressed, the number of malaria parasites increased – along with the expression of other genes responsible for parasite development. Dihydroartemisinin—a key antimalarial drug—ordinarily interferes with these biological processes, but overexpression of the protein leads to reduced sensitivity and resistance. This research reveals more about the parasite lifecycle in the human body and suggests a new drug target against it. Source PfHDAC1 is an essential regulator of P. falciparum asexual proliferation and host cell invasion genes with a dynamic genomic occupancy responsive to artemisinin stress About The Podcast The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

Dr Shane is joined in the studio by regular co-hosts Chris KP and Dr Ray, sharing their science news of the week. This week's guests are Gabriel Lubieniecki, a PhD candidate in the Body Image and Eating Disorders Research Group at Monash University, focussing on the critical role healthcare workers play in the treatment and management of eating disorders. The second guest is Dr Niall Geoghegan, Senior Postdoctoral Fellow at the Centre for Dynamic Imaging at WEHI, researching how the malaria causing parasite, Plasmodium, invades red blood cells and initiates the symptomatic stage of disease, and Dr Natalia Sampan from the Centre for Innate Immunity and Infectious Diseases at the Hudsons Institute, talking about how our cells detect that they have been infected, and how they fight back.Remember, “science is everywhere”, including:Program page: Einstein-A-Go-GoFacebook page: Einstein-A-Go-GoTwitter: Einstein-A-Go-Go

The Alice and C.C. Wang Award in Molecular Parasitology recognizes established investigators who are making seminal contributions to the field of molecular parasitology. David S. Roos is a professor of biology at the University of Pennsylvania. His laboratory studies the biochemistry, cell biology, molecular genetics, genomics and evolutionary biology of protozoan parasites and host–pathogen interactions, with special interest in Toxoplasma, a prominent opportunistic infection associated with immunodeficient states, and Plasmodium, which causes malaria. Learn more: https://www.asbmb.org/asbmb-today/people/081623/asbmb-names-2024-award-winners.

Dando sequência a série "Mudanças climáticas X Saúde", nesta edição do "CBN Meio Ambiente e Sustentabilidade" o tema em destaque é a malária, doença infecciosa, febril, aguda e potencialmente grave. Ela é causada pelo parasita do gênero Plasmodium, transmitido ao homem, na maioria das vezes, pela picada de mosquitos do gênero Anopheles infectados, também conhecido como mosquito-prego. No entanto, também pode ser transmitida pelo compartilhamento de seringas, transfusão de sangue ou até mesmo da mãe para feto, na gravidez. As informações são da Fundação Oswaldo Cruz (Fiocruz). Ouça a conversa completa!

Com auxílio de inteligência artificial (IA), pesquisadores da Universidade Estadual de Campinas (Unicamp), Universidade de São Paulo (USP) e Universidade Federal de Goiás (UFG) identificaram medicamentos já aprovados para o uso em humanos, ou em fase de estudo clínico, que apresentam potencial ação contra o parasita da malária. O alvo do trabalho divulgado na revista ACS Omega foi o Plasmodium falciparum, espécie responsável pelos casos mais graves de malária do país. Segundo os autores destacam no artigo, o uso de ferramentas computacionais pode facilitar a descoberta de fármacos contra o parasita, que tem capacidade de desenvolver resistência rapidamente.

Olá, bio-ouvintes! No episódio de hoje, iremos explorar os complexos detalhes da malária, uma doença que tem afetado comunidades em todo o mundo ao longo da história. Também conhecida como paludismo, a malária é uma doença transmitida por mosquitos infectados do gênero Anopheles. Esses insetos carregam consigo o parasita Plasmodium, responsável por desencadear os sintomas da doença. A malária é uma das doenças tropicais mais prevalentes e, infelizmente, continua a representar um desafio significativo para a saúde pública em muitas regiões.   CONTATOS cartinhas@biologiainsitu.com.br Instagram, Facebook e LinkedIn: @biologiainsitu Twitter e TikTok: @bioinsitu   APOIO Apoio recorrente na Orelo! Ou no Padrim! Pix: cartinhas@biologiainsitu.com.br Também no PicPay!   CRÉDITOS Coordenação por Bruna Canellas, Cristianne Santos, Heloá Caramuru, Ricardo Gomes e Vitor Lopes. Pesquisa, roteiro e locução: Nadja Lopes. Edição e mixagem de áudio: Marina Milito. Arte de capa: Helber Souza.   CITAÇÃO DO EPISÓDIO (ABNT) Biologia In Situ 127 - Bionews - Malária, uma história de zoonose. Coordenação: Bruna Garcia da Cruz Canellas, Cristianne Santana Santos, Heloá Caramuru Carlos, Ricardo da Silva Gomes e Vitor Estanislau de Almeida Souza Lopes. Pesquisa, roteiro e locução: Nadja Francisca Silva Nascimento Lopes. Edição e mixagem de áudio: Marina Milito Góes. Arte de capa: Helber Souza Carvalho. [S. l.] Canal Biologia In Situ, 21 de dezembro de 2023. Podcast. Disponível em: .   REFERÊNCIAS CAMARGO, E.P. Malária, Maleita, Paludismo. Ciência e Cultura online, São Paulo, v. 55, n. 1, p. 26-29, 2003. CÔNSOLI, R. A. G. B.; LOURENÇO-DE-OLIVEIRA, R. L. de. Principais mosquitos de importância sanitária no Brasil. FIOCRUZ, 228 p. 1994.  SANCHES – RIBAS, J.; PARRA-HENAO, G.; GUIMARAES, A. E. Impact of dams and irrigation schemes in Anopheline (Diptera: Culicidae) bionomics and Malaria epidemiology. Revista do Instituto de Medicina Tropical. São Paulo, v. 54, n. 4, p. 179-191, 2012. Disponível em:. Acesso em : 25 set. 2012. TADEI W.P. et al. Incidência, distribuição e Aspectos Ecológicos de Espécies de Anopheles (Díptera: Culicidae), em Regiões Naturais e sob Impacto Ambiental da Amazônia Brasileira. In:Ferreira, EJG et al(Eds.) Bases Científicas para Estratégias de Prevenção e Desenvolvimento da Amazônia. Instituto Nacional de Pesquisas da Amazônia, Manaus, v. 2, p.169-195, 1993. TADEI, W.P.; THATCHER B.D. Malaria vectors in the Brasilian Amazonia: Anopheles of the subgenus Nyssorhynchus. Revista do Instituto de Medicina Tropical de São Paulo. v. 42, p. 87-94, 2000. WORLD HEALTH ORGANIZATION (WHO). World Malaria risk areas. Library: Geneva, 2023.

On today's episode we'll discuss the findings from a phase 2 study of sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML, learn more about the inhibition of PLK4 in TP53-mutated AML, and discuss the role of CD44 in Plasmodium falciparum infection.

Annoncées en octobre 2021 par l'Organisation mondiale de la santé (OMS), les premières livraisons du vaccin antipaludique (RTS, S) ont démarré le 21 novembre. Plus de 330.000 doses du vaccin ont ainsi été livrées au Cameroun après une phase pilote au Ghana, au Kenya et au Malawi. Une étape clé qui prépare le terrain pour une vaccination à grande échelle sur le continent. Pour le docteur Charles Shey Wiysonge, chargé de l'immunisation au bureau régional de l'OMS, cette tournée de vaccinations marque « une étape historique » dans la lutte contre le paludisme. Il est l'invité de Christina Okello. RFI : Quelle est la spécificité du vaccin RTS,S ?Charles Shey Wiysonge : Il s'agit du premier vaccin antipaludique recommandé par l'OMS pour prévenir le paludisme chez les enfants. Le vaccin agit contre le Plasmodium falciparum qui est le parasite du paludisme le plus meurtrier dans le monde et celui qui est le plus présent en Afrique. Les recommandations de l'OMS concernant ce vaccin antipaludique reposent sur les résultats du programme pilote de mise en œuvre du vaccin qui a été conduit dans trois pays, au Ghana, Kenya et Malawi.Le Cameroun n'avait pas participé au programme pilote de vaccination, pourquoi a-t-il été choisi pour recevoir les premières doses ?Le Cameroun, et d'autres pays, vont recevoir la livraison dans les prochaines semaines, ce sont les premiers pays qui ont soumis une demande de soutien à Gavi, l'Alliance du vaccin. Puisque la forte demande a dépassé l'offre disponible, on a limité l'allocation de stocks parce qu'on a environ 18 millions de doses, donc avec 28 pays, c'était difficile. Donc il y en a un quart qui a été développé avant que les pays ne fassent la demande.Quelle est la situation du paludisme au Cameroun, et ailleurs ?Dans les pays comme le Cameroun, le Nigeria, c'est vraiment un grand problème de santé publique. Il y a au moins 10% de la population qui est atteinte du paludisme.Quelle est l'importance de ce vaccin pour la lutte contre le paludisme ? C'est une étape très importante parce que le vaccin est très efficace pour réduire le nombre de cas de paludisme causé par le Plasmodium falciparum chez les jeunes enfants et il réduit les formes graves. Après l'introduction du vaccin dans le programme pilote, on a constaté une baisse très remarquable du nombre d'enfants hospitalisés et une diminution du nombre de décès chez les enfants d'environ 13%. Donc c'est vraiment important.Quelle est l'efficacité du vaccin RTS,S compte tenu de la résistance du paludisme aux médicaments ?Il y a une résistance seulement quand quelqu'un a déjà le paludisme. On a vu qu'après trois doses de ce vaccin, il y a une diminution de 75% des cas de paludisme pendant la première année. C'est vrai que l'efficacité diminue, c'est pour cela qu'on recommande qu'un an après la troisième dose, il faut en donner une quatrième, et aussi un an après ça, il en faut une cinquième. Qui peut prendre le vaccin RTS,S ?On recommande quatre doses aux enfants à partir de l'âge de cinq mois. Par exemple, au Cameroun, le calendrier vaccinal prévoit qu'il y ait quatre doses, à six mois, à sept mois, à neuf mois et à vingt-quatre mois d'âge. C'est seulement pour les enfants.Le mois dernier, l'OMS a donné son feu vert à l'utilisation pour les enfants d'un deuxième vaccin antipaludique, le R21, quelle est la différence avec le vaccin RTS,S ?Il n'y a pas de différence, les deux vaccins agissent de la même manière. Mais pour le premier vaccin, il y a seulement, environ, dix-huit millions de doses qui seront disponibles d'ici 2025. Ce n'est pas suffisant. Au moins vingt-huit pays d'Afrique envisagent d'introduire ces vaccins contre le paludisme dans leur programme de vaccination d'enfants. Mais ce qui est aussi important, c'est que l'autre vaccin, le fabriquant a dit qu'ils vont produire beaucoup plus de doses que dix-huit millions, donc d'ici la fin de l'année prochaine, on n'aura pas de problèmes de stocks limités.Après le Cameroun, quels sont les prochains pays destinataires du vaccin?Après le Cameroun, il y aura le Burkina Faso, le Liberia, il y aura le Niger et la Sierra Leone. D'après les nouvelles qu'on a, le gouvernement du Cameroun prévoit de commencer la campagne de vaccination le 12 décembre. Quand va démarrer la vaccination à grande échelle sur le continent ?Chaque pays a son calendrier. Par exemple, le Cameroun va commencer en décembre. Il y a d'autres pays, comme le Burkina Faso, il y a le Burundi, il y a la RDC, on prévoit qu'il y aura cinq pays entre janvier et juin, parce qu'on pense que l'autre vaccin R21 sera disponible à partir de juin. Donc on pense qu'il y aura un peu plus de pays après juin.Et que signifie pour l'Afrique cette vaccination à grande échelle ?Chaque année, il y a autour de 500 000 enfants qui meurent dans le monde et la plupart, 95%, sont en Afrique. Si on a un vaccin, il va diminuer ce taux de mortalité. On a vu la réduction du taux de mortalité au Ghana, au Kenya, au Malawi, autour de 13%. Vous imaginez, un taux de réduction de 13% de la mortalité ? Et il y a une diminution des cas de paludisme de 75%. Donc c'est un grand atout pour la lutte contre le paludisme, je pense que c'est un moment historique pour l'Afrique et pour la vaccination en général.

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Plasmodium⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Microbiology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

Si Internet fue un país estaría entre los cinco mayores consumidores de electricidad del mundo. Solo el entrenamiento del ChatGPT requirió una energía equivalente al consumo de un hogar medio español durante 23 años. Cada vez que navegamos por la red dejamos un rastro de datos y de CO2. Reducir el consumo energético de la Inteligencia Artificial es el objetivo de la profesora de la Universidad de La Coruña, Verónica Bolón, que trabaja en el diseño de algoritmos verdes. Alda Olafsson nos ha ampliado una de las buenas noticias de este verano, la cesión a la OMS de la patente de la vacuna contra el coronavirus desarrollada por el CSIC (con testimonios de Ana Sanz, responsable de la oficina de apoyo al desarrollo de terapias y vacunas covid-19, de la Vicepresidencia de Innovación y Transferencia del CSIC). -En nuestra "Historia de la ciencia", Nuria Martínez Medina ha trazado la biografía del francés La Condamine, uno de los protagonistas de la expedición a Perú para determinar la longitud del arco del meridiano terrestre. Con Lluís Montoliu hemos analizado el alcance de las últimas investigaciones sobre un pangenoma que actúe de referencia para todos los seres humanos. José Antonio López Guerrero nos ha informado del hallazgo por serendipia de una bacteria del género Delftia que se desarrolla de forma natural en el intestino del mosquito Anopheles y bloquea el desarrollo del Plasmodium que causa la malaria. Con Bernardo Herradón hemos continuado nuestra exploración de la tabla periódica y en concreto, del litio, ese elemento clave y estratégico para las nuevas tecnologías. Eulalia Pérez Sedeño nos ha acercado a la biografía de la paleontóloga Ekaterina Vladimirovna, la primera persona en investigar los trilobites en la antigua Unión Soviética, creadora de la primera estratigrafía cámbrica de Siberia. Escuchar audio

On episode #32 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/21 – 7/4/23. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Clinical characteristics and outcomes among travelers with severe dengue (AIM) Phase 3 randomized trial of Bulevirtide in chronic hepatitis D (NEJM) Increased peripheral inflammation associated with structural brain changes and reduced blood flow in virologically controlled people with HIV (JID) Sustained viral suppression with dolutegravir monotherapy over 192 weeks in HIV patients (CID) Side-by-side comparative study of the immunogenicity of the intramuscular and intradermal rabies post-exposure prophylaxis regimens in suspected RABV exposed individuals (CID) Reliability of admission procalcitonin testing for capturing bacteremia across the sepsis spectrum (CCM) Early discontinuation of antibiotics in patients admitted with clinically suspected serious infection but negative cultures (OFID) Short-course therapy for urinary tract infections in children (JAMA) Autochthonous Leprosy in the United States (NEJM) Management of pediatric pneumonia (CID) Added value of (1,3)-β-D-glucan for the diagnosis of Invasive candidiasis in ICU patients (Infection) Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles (PLOS Pathogens) Locally acquired malaria cases identified in the US (CDC) Nanoplasmonic amplification in microfluidics enables accelerated colorimetric quantification of nucleic acid biomarkers from pathogens (NN) Music is by Ronald Jenkees

7 locally transmitted malaria cases have been reported in the US (Texas and Florida), a first in quite a few years. The species of malaria has been identified as Plasmodium vivax, one of 5 plasmodium species that can infect humans. What is malaria?, what is Plasmodium vivax?, how important is this transmission and how to prevent it? These and other questions will be posed to my guest today. Joining me today is Brian Grimberg, PhD. Dr. Grimberg is an Associate Professor, Department of Pathology, at the Case Western Reserve University School of Medicine and a prominent malaria researcher. Follow the website, Outbreak News Today For video interviews- Outbreak News TV

TWiP solves two cases this week, the Man with Issues after COVID-19, and the Man with Left Arm Weakness, then describe how the malaria parasite evades mosquito immunity by glutaminyl cyclase–mediated posttranslational protein modification. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Malaria parasite evades mosquito immunity (Proc Natl Acad Sci USA) Letters read on TWiP 218 Become a patron of TWiP Case Study for TWiP 218 A fun twist for today. Did I mention recently I was spending time with Paul Calle at the Central Park and instead of Jeff Bezos showing up for Dinner Chevy Chase was there. Here we have the case of a 19 month old female who seems to be having some issues. Lots of increased respiratory effort even with minimal exertion. Some issue with loose stools and then followed by the onset of facial swelling.  No sig PMH or PSH, fairly confident there is not smoking or drinking of alcohol and certainly not HIV+. On exam the increased respiratory effort that is audible. Directed testing reveals canine coccidia and giardia in the stool. So what is going on? Should I be worried about my daughter who has had lots of exposure? Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiP solves the case of the Man With Dog Exposure, and discuss rapid and spontaneous post-partum clearance of Plasmodium falciparum related to expulsion of the placenta. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Post-partum clearance of P. falciparum (J Inf Dis) Letters read on TWiP 217 Become a patron of TWiP Case Study for TWiP 217 We have two cases today! A man in his 60s who provides IT support for a bank and all done via zoom and remote work is referred to me. He reports having issues after COVID diagnosis Sept 5th, 2022. He had 4 vaccine doses and with diagnosis was treated with Paxlovid. Feel better than about week 3 wakes up with URI symptoms for about one week and by the 28th was improving. He had cold agglutinins detected. Referred to ophtho by his primary with some eye discomfort and noted to have elevated intra-ocular pressure elevation. Sleep and fatigue were a problem but slowly improving. Cognitive issues noted but improving.  He reports an issue a few years prior to this current problem where he developed fever, a sore throat, tender lymph nodes in the neck both in front and in the back. This resolved after about a week but was then followed by months of fatigue, sleep disturbances and not feeling well.  He reports no specific dietary preferences and reports no cat exposures. He saw several physicians and one did a number of blood tests.  A man in his late 30s presented to an ER at an outside hospital prior to ultimately being transferred to an academic center in NYC.. He reports onset of left arm weakness that prompted him to come to the ER. He reports on pointed questioning that he had COVID about one month prior and felt he had fully recovered. He did have a headache that preceded the onset of weakness. The OSH triggers their stroke protocol and perform a head CT which reveals a hypodense lesion on the right side of the brain not consistent with a stroke. A bit more history is obtained, some further testing is done,and based on this the patient is transferred on some sort of therapy. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #28 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/26 – 5/10/23. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Unprecedented outbreak of West Nile Virus (CDC) Approval of first RSV vaccine approved for individuals 60 years and older (FDA) FDA approves orally administered fecal microbiota product for the prevention of recurrence of C-difficile (FDA) Using thermal imaging to track cellulitis (OFID) Burden of Typhoid and Paratyphoid fever in India (NEJM) Early switch to oral antimicrobials in brain abscess (CMI) Considering vancomycin alternatives for pediatric methicillin-resistant Staphylococcus aureus bacteremia (JPIDS) Navigating treatment options for Carbapenem-Resistant Acinetobacter baumannii-calcoaceticus complex infections (CID) 2023 Duke-ISCVID criteria for infective Endocarditis (CID) Molecular characterization of Candida auris outbreak isolates in Qatar from COVID-19 patients (CMI) Amplicon sequencing reveals complex infection in infants congenitally infected with Trypanosoma cruzi (JID) Impact of Sequestration on Artemisinin-Induced Parasite Clearance in Plasmodium falciparum Malaria (CID) Advances in artificial intelligence for infectious disease surveillance (NEJM) Music is by Ronald Jenkees

Tanya Latty is an insect scientist with a quirky taste in pets, and a keen eye for detail. But it's the lessons from her brainless pet slime mould that she's most fascinated about

Tanya Latty is an insect scientist with a quirky taste in pets, and a keen eye for detail. But it's the lessons from her brainless pet slime mould that she's most fascinated about

Malaria continues to have a significant impact on humans. The Plasmodium parasites are transmitted through mosquito bites, and the disease has a tremendous impact on global health. Dr. Debopam Chakrabarti, a professor at the University of Central Florida who specializes in malaria. Dr. Chakrabarti discusses the history of the search for antimalarials, the problem of parasite drug resistance, how undergraduates can help to discover the next antimalarials, whether eradication of mosquitoes will eliminate malaria, and his challenging passion in growing roses in Florida. This episode was supported by ArchaeaMingle.com, for single-celled organisms looking for a steamy time. Participants: Karl Klose, Ph.D. (UTSA) Debopam Chakrabarti, Ph.D. (University of Central Florida) Janakiram Seshu, Ph.D. (UTSA) Jim McLellan (UTSA)

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: World Malaria Day: Reflecting on Past Victories and Envisioning a Malaria-Free Future, published by 2ndRichter on April 25, 2023 on The Effective Altruism Forum. World Malaria Day, inaugurated in 2017 by the United Nations World Health Organization, reminds us of malaria's impact on humanity and the role we can take in preventing the disease. Malaria was only eradicated from areas like Europe as recently as the 1970s, and nearly half of the world's population was still at risk of malaria in 2021. Over 600,000 people died of malaria in 2021 and 247 million people contracted the disease in 2021—and three-quarters of those deaths were children under five. Almost half of the world's countries have eradicated malaria since 1945, and we have reason to hope that countries still affected can eradicate it as well. With significant scientific advancements, we know that effective malaria prevention can be impactful and relatively cheap. Typical interventions to prevent and treat malaria include insecticide-treated bednets, removing standing water from affected areas, and antiviral medications—and some of these interventions are relatively cheap. Only $5 USD can provide one malaria net and $7 can protect a child from malaria through malaria chemoprevention. Roughly $5000 USD will provide enough bednets or seasonal medicine doses to save someone's life. Recent advances in vaccines against malaria and in work exploring the use of gene drives provide further hope that we could eradicate malaria from countries that are still affected. On World Malaria Day, we encourage you to donate to Giving What We Can's fundraiser partnering with the Against Malaria Foundation and the Malaria Consortium. Malaria is preventable and treatable; a lack of resources leaves people personally affected by the disease or affected by the loss of loved ones. Your giving can directly impact the lives of those affected by malaria: if we reached the $1 million USD fundraising goal, we could directly prevent roughly 200 deaths from malaria. Put simply, this is an area where we really can make a difference. Plasmodium falciparum prevalence from 2000 to 2019. The decreasing amount of red, orange, and yellow represents the decreasing prevalence of one of the deadliest strains of malaria due to prevention efforts. Data from, animation idea by Sam Deere. Where we've been Malaria has been a part of human history for thousands of years, from infections in ancient Rome to the infections of several U.S. presidents. Early treatment for malaria came in the form of quinine from the cinchona tree, first isolated by French chemists in 1820, and was commonly administered in the form of tonic water or the gin and tonic. French surgeon Alphonse Laveran discovered the plasmodium parasite as the cause of malaria in 1880, opening up further research that would identify antimalarials like chloroquine and DDT. Proportion of deaths from malaria to deaths from all causes in the eastern United States, 1870 US Census. From Our World In Data/Statistical Atlas from the 9th Census of the United States 1870 (published 1874). Fighting malaria was the impetus for developing public health infrastructure in a number of countries. The predecessor to the United States Centers for Disease Control was the Office of Malaria Control in War Areas, designed to limit the impact of malaria during World War II around US military bases in the Southern United States (hence its headquarters in Atlanta, Georgia rather than Washington DC). Roughly half of the world's countries have eliminated malaria in their territories through public health efforts, including some in tropical regions where malaria is most likely to be prevalent. 79 countries eliminated malaria from 1945 to 2010, and several more since 2010. Countries must achieve at least three consecutive y...

In this episode, I am joined by Dr. Chris Damman, Chief Medical & Scientific officer at UR Labs, and Marc Washington the Founder & CEO of Supergut. We discuss gut health and why it's essential for overall health. They explain that the gut is not just about digestion but a portal to whole health. They also discuss how what we eat and breathe can affect our gut and body health. The episode highlights the importance of understanding gut health and how healthcare professionals should incorporate this information into patient care.   Show notes:  [00:01:01] Gut health and whole health. [00:04:34] Gut health and total health. [00:07:45] The gut and immune system. [00:12:23] Gut health and nutrition decisions. [00:15:11] Four F's of Longevity. [00:19:03] Probiotics and Gut Health. [00:24:51] Different types of fiber. [00:28:00] Blood sugar spikes and fiber. [00:31:11] Chronic conditions and mind-body connection. [00:36:10] Double burden of disease. [00:40:23] Gut health and interconnectedness. [00:43:46] Following your passions.   More About Dr. Damman: Chris Damman is Chief Medical & Scientific officer at UR Labs.  Prior to joining UR Labs, he was Initiative Lead of Gut Health in the Enteric and Diarrheal Diseases team at the Bill & Melinda Gates Foundation.  He holds an M.D. from Columbia University and an M.A. in Molecular Biology & Biochemistry from Wesleyan University.  He moved west to complete his residency in internal medicine and fellowship in gastroenterology at the University of Washington.  Chris continued on at the University of Washington with a joint appointment in the Division of Gastroenterology and The Fred Hutchinson Cancer Research Center.  He maintains an academic appointment with the University of Washington with research interests focused on investigating the role of diet and microbiome-directed therapies as treatments for inflammatory bowel disease.  Past research activities have included early drug discovery work at Pfizer's Discovery Technology Center in Cambridge, MA and epidemiological surveillance work characterizing Plasmodium drug resistance genes at the Armed Forces Research Institute of Medical Sciences in Bangkok, Thailand. Outside of work, Dr. Damman likes to spend his time running, cooking, eating, and spending time with his wife and three daughters.    More About Marc: Marc Washington is the Founder & CEO of Supergut. His background spans a wide variety of consumer health businesses, including serving as the CEO of Irwin Naturals, a $100M+ supplements company and leading producer of soft-gel herbal formulas sold in over 90,000 retail outlets; President & COO of Beachbody, a $1B+ nutrition and fitness company with products including Shakeology health shakes, P90X, and the Beachbody-on-Demand digital platform; and working 9 years at The Wonderful Co, a $4B agriculture and food & beverage holding company, where he served in a variety of roles including CFO (corporate), EVP Sales (Teleflora), and Direct of Strategy & Operations (FIJI Water). Marc's deep experience in the wellness industry inspired him to found Supergut to help people regain control of their health by harnessing the powerful science of the gut biome. Marc holds an M.B.A. from Harvard Business School and B.S. from Princeton University.  Marc's areas of expertise: Entrepreneurship, Health & Wellness, Gut Health, Metabolic Health, Nutrition, Prebiotic Fiber & Resistant Starch, Food As Medicine, Nutrition & Public Health, Multicultural Health Disparities, Diversity & Inclusion   Resources from this Episode:  Website Our recently peer-reviewed and published clinical study SuperGut on Instagram SuperGut on TikTok SuperGut on Twitter   Follow Dr. Karen Litzy on Social Media: Karen's Twitter Karen's Instagram   Subscribe to Healthy, Wealthy & Smart: YouTube Website Apple Podcast Spotify SoundCloud Stitcher iHeart Radio      

On episode #22 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 2/2 – 2/15/23. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Influence of rapid influenza diagnostic testing on clinician decision-making for patients with acute respiratory infection (CID) Outbreak of extensively drug-resistant Pseudomonas aeruginosa (CDC) Epidemiology and clinical outcomes of non-HACEK gram-negative infective endocarditis (OFID) Azithromycin to prevent sepsis or death in women planning a vaginal birth (NEJM) Clinical significance of concomitant bacteruria in patients with Staphylococcus aureus bacteremia (EJCM) Health disparities in hemodialysis associated Staph aureus bloodstream infections (CDC) Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteremia (CMI) Genome-wide analysis of transposon mobility in the human fungal pathogen Cryptococcus deneoformans (PNAS) Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia (CID) Prevalence of Ocular Complications in candidemia (CID) Rapid and spontaneous post-partum clearance of Plasmodium falciparum (JID) Adoption and utilization of social media among adult and pediatric infectious diseases divisions and fellowship programs (OFID) Canine detection of chronic wasting disease in laboratory and field settings (Prion) Music is by Ronald Jenkees

On episode #18 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/9/22 – 12/21/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Human Rabies in Texas, 2021 (CDC) Human rabies despite post-exposure prophylaxis (The Lancet) The Qatar FIFA World Cup 2022 and camel pageant championships increase risk of MERS-CoV transmission and global spread (The Lancet) An update on eukaryotic viruses revived from ancient permafrost (bioRx) Colistin monotherapy vs combination therapy for carbapenem-resistant organisms (NEJM) Outcomes of Ceftriaxone vs antistaphylococcal Penicillins or Cefazolin for definitive therapy of Methicillin-susceptible Staphylococcus aureus bacteremia (OFID) Salmonella enteritidis cardiovascular implantable electronic device infection (OFID) Evaluation of serotonin syndrome with Linezolid and serotonergic agents at an academic medical center (OFID) Preemptive antifungal therapy for the prevention of invasive candidiasis following gastrointestinal surgery for Intra-abdominal infections (CID) Risk factors and outcomes of invasive aspergillosis in kidney transplant recipients (CID) Predictive performance of gram staining of catheter tips for Candida catheter-related bloodstream infections (OFID) Integrative genetic manipulation of Plasmodium cynomolgireveals multidrug resistance-(JID) Clinical characteristics of patients with calcified parenchymal neurocysticercosis and perilesional edema (OFID) Impact of sequestration on artemisinin-induced parasite clearance in Plasmodium falciparum malaria in Africa (CID) Factors contributing to delayed academic advancement of women in infectious diseases (OFID) Characterization of problematic alcohol use among physicians (JAMA) Alpha-gal syndrome in the ID clinic (OFID) Efficacy and safety of Azithromycin vs placebo to treat lower respiratory tract infections associated with low procalcitonin (The Lancet) Music is by Ronald Jenkees

Maria Manuel Mota é bióloga e uma autoridade internacional na investigação sobre a malária. Doutorou-se em Parasitologia Molecular pela University College London, no Reino Unido, e, depois de ter feito investigação sobre a malária internacionalmente, regressou a Portugal em 2002, onde tem continuado a desenvolver investigação que lhe tem valido diversas distinções. Desde 2014, assumiu também funções de Diretora Executiva do Instituto de Medicina Molecular, em Lisboa. -> Apoie este projecto e faça parte da comunidade de mecenas do 45 Graus em: 45grauspodcast.com -> Página do 45 Graus no Youtube _______________ Índice da conversa: (4:03) O que te levou a estudar a malária? | Progressos nos últimos anos na investigação nesta área. | Against Malaria Foundation (considerada pela Givewell a instituição mais eficaz do mundo)  (18:41) Nova vacina contra a malária (Oxford) | Adrian Hill | Vacina Gsk.  (27:04) O que causa a malária, e como nos infecta. Plasmodium. | Porque se manifesta de maneira diferente nas pessoas. | Como a anemia falciforme protege contra a malária.  (35:19) A importância da investigação em ciência fundamental. | A vantagem do IMM em ter uma ligação ao hospital (45:11) Importância e desafios da interdisciplinaridade na ciência. | Horizontes iMM: Uma Pergunta a Três | série: Diagnosis (59:41) Forças e limitações de Portugal na investigação científica. | Investigação de Bruno Silva-Santos | O que é preciso corrigir no financiamento em Portugal? | Independência da FCT. (1:13:44) Dificuldade em atrair doutorados para a investigação fundamental.  (1:29:08) Problemas do actual sistema de publicação e avaliação científica. | PLOS (Open Science) Livro recomendado: Empire of Pain, de Patrick Radden Keefe  _______________ Obrigado aos mecenas do podcast: Julie Piccini, Ana Raquel Guimarães Galaró family, José Luís Malaquias, Francisco Hermenegildo, Nuno Costa, Abílio Silva, Salvador Cunha, Bruno Heleno, António llms, Helena Monteiro, BFDC, Pedro Lima Ferreira, Miguel van Uden, João Ribeiro, Nuno e Ana, João Baltazar, Miguel Marques, Corto Lemos, Carlos Martins, Tiago Leite Tomás Costa, Rita Sá Marques, Geoffrey Marcelino, Luis, Maria Pimentel, Rui Amorim, RB, Pedro Frois Costa, Gabriel Sousa, Mário Lourenço, Filipe Bento Caires, Diogo Sampaio Viana, Tiago Taveira, Ricardo Leitão, Pedro B. Ribeiro, João Teixeira, Miguel Bastos, Isabel Moital, Arune Bhuralal, Isabel Oliveira, Ana Teresa Mota, Luís Costa, Francisco Fonseca, João Nelas, Tiago Queiroz, António Padilha, Rita Mateus, Daniel Correia, João Saro João Pereira Amorim, Sérgio Nunes, Telmo Gomes, André Morais, Antonio Loureiro, Beatriz Bagulho, Tiago Stock, Joaquim Manuel Jorge Borges, Gabriel Candal, Joaquim Ribeiro, Fábio Monteiro, João Barbosa, Tiago M Machado, Rita Sousa Pereira, Henrique Pedro, Cloé Leal de Magalhães, Francisco Moura, Rui Antunes7, Joel, Pedro L, João Diamantino, Nuno Lages, João Farinha, Henrique Vieira, André Abrantes, Hélder Moreira, José Losa, João Ferreira, Rui Vilao, Jorge Amorim, João Pereira, Goncalo Murteira Machado Monteiro, Luis Miguel da Silva Barbosa, Bruno Lamas, Carlos Silveira, Maria Francisca Couto, Alexandre Freitas, Afonso Martins, José Proença, Jose Pedroso, Telmo , Francisco Vasconcelos, Duarte , Luis Marques, Joana Margarida Alves Martins, Tiago Parente, Ana Moreira, António Queimadela, David Gil, Daniel Pais, Miguel Jacinto, Luís Santos, Bernardo Pimentel, Gonçalo de Paiva e Pona , Tiago Pedroso, Gonçalo Castro, Inês Inocêncio, Hugo Ramos, Pedro Bravo, António Mendes Silva, paulo matos, Luís Brandão, Tomás Saraiva, Ana Vitória Soares, Mestre88 , Nuno Malvar, Ana Rita Laureano, Manuel Botelho da Silva, Pedro Brito, Wedge, Bruno Amorim Inácio, Manuel Martins, Ana Sousa Amorim, Robertt, Miguel Palhas, Maria Oliveira, Cheila Bhuralal, Filipe Melo, Gil Batista Marinho, Cesar Correia, Salomé Afonso, Diogo Silva, Patrícia Esquível , Inês Patrão, Daniel Almeida, Paulo Ferreira, Macaco Quitado, Pedro Correia, Francisco Santos, Antonio Albuquerque, Renato Mendes, João Barbosa, Margarida Gonçalves, Andrea Grosso, João Pinho , João Crispim, Francisco Aguiar , João Diogo, João Diogo Silva, José Oliveira Pratas, João Moreira, Vasco Lima, Tomás Félix, Pedro Rebelo, Nuno Gonçalves, Pedro , Marta Baptista Coelho, Mariana Barosa, Francisco Arantes, João Raimundo, Mafalda Pratas, Tiago Pires, Luis Quelhas Valente, Vasco Sá Pinto, Jorge Soares, Pedro Miguel Pereira Vieira, Pedro F. Finisterra, Ricardo Santos _______________ Esta conversa foi editada por: Hugo Oliveira _______________ Bio: Maria Manuel Mota Licenciou-se em Biologia e obteve o grau de Mestre em Imunologia pela Universidade do Porto. Em 1998 doutorou-se em Parasitologia Molecular pela University College London, no Reino Unido. Maria M. Mota desenvolveu investigação como investigadora pós-doutorada no Laboratório do Prof. Vitor Nussenzweig da New York University Medical School, nos Estados Unidos e lecionou na mesma escola médica. Regressou a Portugal em 2002, onde liderou o seu grupo de investigação do Laboratório de Biologia Celular da Malária, Instituto Gulbenkian de Ciência, em Oeiras, tendo-se tornado em 2005 investigadora principal da Unidade de Malária no iMM, além de lecionar na Faculdade de Medicina da Universidade de Lisboa. Maria M. Mota é atualmente Diretora Executiva do iMM e Professora Convidada na Harvard School of Public Health, nos Estados Unidos. O seu trabalho no campo da malária centra-se no estudo de ambas as fases da infeção (hepática, sanguínea) por Plasmodium, o parasita causador da malária, no hospedeiro humano. Maria M. Mota venceu o EMBO Young Investigator Award em 2003, o European Young Investigator Award da European Science Foundation em 2004, e foi investigadora internacional do Howard Hughes Medical Institute (EUA) entre 2005 e 2010. Em Maio de 2016 foi eleita para integrar a Organização Europeia de Biologia Molecular (European Molecular Biology Organization – EMBO). Em 2017 recebeu o prémio Pfizer e em 2018 o Prémio Sanofi – Institut Pasteur – Mid-Career category. Em Portugal foi condecorada pelo Presidente da República com a Ordem do Infante D. Henrique em 2005 e foi agraciada com o Prémio Pessoa em 2013. Em 2019 recebeu o Prémio Dona Antónia-Consagração de Carreira. Maria Manuel Mota é uma voz ativa pelos direitos das mulheres e equidade de oportunidades na educação. Atualmente tem uma coluna de opinião mensal no jornal Expresso, como um contributo para alcançar o seu sonho de viver numa sociedade centrada no conhecimento. 

Parasites are known contributors to human disease and suffering, spanning a wide range of organisms. Dr. Jessie Kissinger from the University of Georgia has spent the last two decades curating genomic data from hundreds of parasites, their vectors and hosts. The information helps researchers generate hypotheses about parasites, and presents a fertile resources for comparing genomes and understanding similarities and differences across this diverse set of organisms. VEuPathDB.org  (Vector and Eukaryotic Pathogens Resource Center)ClinEpiDB.org (Clinical and Epidemiological resource with DIY analyses and many BGMF studies) @jcklab   (Dr. Kissinger twitter)mango.ctegd.uga.edu  (lab website)

In this episode of the Epigenetics Podcast, we caught up with Elena Gomez-Diaz from the Institute of Parasitology and Biomedicine López-Neyra at the Spanish National Research Council. She share with us her work on the Epigenetics in Human Malaria Parasites. Elena Gómez-Díaz and her team are focusing on understanding how epigenetic processes are implicated in host-parasite interactions by regulating gene expression in the model of malaria. The team has started to investigate and uncover layers of chromatin regulation that control developmental transitions in Plasmodium falciparum, especially in the parts of the life cycle that take place in the mosquito. Furthermore, the lab has investigated epigenetic changes that are present in malaria-infected Anopheles mosquitos, this led to the identification of cis-regulatory elements and enhancer-promoter networks in response to infection.   References Gómez-Díaz E, Rivero A, Chandre F, Corces VG. Insights into the epigenomic landscape of the human malaria vector Anopheles gambiae. Front Genet. 2014 Aug 15;5:277. doi: 10.3389/fgene.2014.00277. PMID: 25177345; PMCID: PMC4133732. Gómez-Díaz, E., Yerbanga, R., Lefèvre, T. et al. Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae. Sci Rep 7, 40655 (2017). https://doi.org/10.1038/srep40655 José Luis Ruiz, Juan J Tena, Cristina Bancells, Alfred Cortés, José Luis Gómez-Skarmeta, Elena Gómez-Díaz, Characterization of the accessible genome in the human malaria parasite. Plasmodium falciparum, Nucleic Acids Research, Volume 46, Issue 18, 12 October 2018, Pages 9414–9431, https://doi.org/10.1093/nar/gky643 Women in Malaria 2021: A Conference Premier. (2021). Trends in Parasitology, 37(7), 573–580. https://doi.org/10.1016/j.pt.2021.04.001 Twitter Account: https://twitter.com/womeninmalaria   Related Episodes Multiple challenges of CUT&Tag (Cassidee McDonough, Kyle Tanguay) ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

On episode #14 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 10/13/22 – 10/26/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Relative Effectiveness of cell-based versus egg-based quadrivalent Influenza vaccines in adults (OFID) Oral is the new iv. challenging decades of Blood and Bone Infection Dogma (American Journal of Medicine) The burden of bacterial antimicrobial resistance in the WHO European region in 2019 (The Lancet) What is the appropriate dose, route and duration of antibiotic therapy for pediatric acute hematogenous osteomyelitis? (JPIDS) How generalizable are Randomized Controlled Trials in Staphylococcus aureus Bacteremia? (CID) Current treatments against mucormycosis and future directions (PLOS) The Effect of regularly dosed Acetaminophen vs no Acetaminophen on renal function in Plasmodium knowlesi Malaria (IDSA) The value of metagenomic next-generation sequencing in Leishmaniasis diagnosis (OFID) AmBisome monotherapy and combination AmBisome–Miltefosine therapy for the treatment of Visceral Leishmaniasis in patients coinfected With HIV (CID) Does Calcified Neurocysticercosis affect migraine characteristics and treatment responsiveness? (ASTMH) Association between personal ambient carbon dioxide level monitoring and incidence of Tuberculosis infection (CID) Change in the perception of oral antibiotics among medical students (OFID) Impact of antivenom administration on the evolution of cutaneous lesions in loxoscelism (PLOS) Music is by Ronald Jenkees

Today we talk about how crystallizing human urine can help save seagrass, a new AI program that can detect early signs of heart disease, and how mosquitos can be used to vaccinate against malaria. Pee and Seagrass “Human Pee Might Just Be the Key to Saving Seagrass” by Jesse Kathanhttps://www.smithsonianmag.com/innovation/human-pee-might-just-be-the-key-to-saving-seagrass-180980368/“Use of a wastewater recovery product (struvite) to enhance subtropical seagrass restoration” by C. MacDonnella, F. Bydalek, T.Z. Osborne, A. Beard, S.Barbour, D.Leonard, J. Makinia, and P.W. Ingletta.https://www.sciencedirect.com/science/article/abs/pii/S0048969722028133Heart Sound Maps “Low-cost disease diagnosis by mapping heart sounds” by American Institute of Physicshttps://phys.org/news/2022-08-low-cost-disease-diagnosis-heart.html“Low-Cost Disease Diagnosis By Mapping Heart Sounds” by Addrew Shawnhttps://vervetimes.com/low-cost-disease-diagnosis-by-mapping-heart-sounds-sciencedaily/“Aortic Stenosis Overview”https://www.heart.org/en/health-topics/heart-valve-problems-and-disease/heart-valve-problems-and-causes/problem-aortic-valve-stenosis“Epidemiology of Aortic Valve Stenosis (AS) and of Aortic Valve Incompetence (AI): Is the Prevalence of AS/AI Similar in Different Parts of the World?”https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-18/epidemiology-of-aortic-valve-stenosis-as-and-of-aortic-valve-incompetence-ai#:~:text=Aortic%20stenosis%20is%20the%20second,increasing%20prevalence%20with%20advancing%20age.Modified Mosquitos “A box of 200 mosquitoes did the vaccinating in this malaria trial. That's not a joke!” By Max Barnharthttps://www.npr.org/sections/goatsandsoda/2022/09/21/1112727841/a-box-of-200-mosquitoes-did-the-vaccinating-in-this-malaria-trial-thats-not-a-jo“Malaria: Frequently Asked Questions” by CDChttps://www.cdc.gov/malaria/about/faqs.html#:~:text=Symptoms%20and%20Diagnosis,-What%20are%20the&text=Symptoms%20of%20malaria%20include%20fever,loss%20of%20red%20blood%20cells.“Malaria” by World Health Organizationhttps://www.who.int/news-room/fact-sheets/detail/malaria“A genetically engineered Plasmodium falciparum parasite vaccine provides protection from controlled human malaria infection” by Murphy et al.https://www.science.org/doi/10.1126/scitranslmed.abn9709Follow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers.Find episode transcripts here: https://curiosity-daily-4e53644e.simplecast.com/episodes/pee-and-seagrass-heart-sound-maps-modified-mosquitos

Este verano de 2022 está siendo uno de los más cálidos desde que existen registros, con tres olas de calor y noches tropicales. También es de los peores en cuanto a incendios forestales y sequía. La situación no es mejor en el resto del mundo donde los fenómenos extremos se suceden. Según un estudio publicado esta semana en Nature, la situación tiende a empeorar. Y advierte que las medidas que se aplicaban hace 10 ó 20 años se han quedado obsoletas porque los fenómenos son cada vez más extremos. Otro artículo más alarmante todavía, publicado en la revista PNAS, asegura que el mundo debe empezar a prepararse para la posibilidad de un ‘final climático’. Hemos entrevistado a Fernando Valladares Ros, responsable del grupo de Ecología y Cambio Global en el Museo Nacional de Ciencias Naturales, y coautor del libro “La salud planetaria” (CSIC-Catarata). Entre las secciones que hemos recuperado para este programa, el doctor Pedro Gargantilla nos comentó la relación de la medicina con “Los cuentos de Hoffman”, la ópera más famosa de Jacques Offenbach. Álvaro Martínez del Pozo dedicó su sección de “Moléculas imprescindibles para la vida” a la artemisinina, descubierta y caracterizada en China, y muy eficaz contra el parásito de la malaria (Plasmodium falciparum). José Luis Trejo nos explicó qué es la estimulación cerebral profunda, con electrodos, y sus aplicaciones. Javier Cacho nos contó como el deshielo de los polos está abriendo nuevas rutas marinas por el Ártico con todo lo que eso implica. Eulalia Pérez Sedeño trazó la biografía de Dolores Vilar Gallego, una de las principales impulsoras y presidenta de la Asociación Española de Mujeres Médicos, además de jefa de sección de Pediatría del Instituto Médico Valenciano. Escuchar audio

https://www.metaculus.com/notebooks/10685/malaria-and-the-historic-rtss-vaccine/ The following essay was contributed by public health researcher Jon Servello.   This essay makes extensive use of abbreviations. The list can be found here. Malaria caused 627,000 deaths in 2020, largely among children under five years of age in sub-Saharan Africa. Interventions aimed at preventative treatment could save a considerable number of lives, bring about long-term economic benefits to countries with endemic malaria, and yield substantial benefits to humanity as a whole.  After decades of varied success in vaccine development, a four-dose regimen of RTS,S/AS01 (brand name Mosquirix) showed promising initial results in preventing clinical disease from Plasmodium falciparum at 11 trial sites across west and central Africa, though this quickly declined to an average of 25.9% efficacy in the 6 to 12 week old age range, and 36.3% in the 5 to 17 month range. The European Medicines Agency licensed the vaccine in 2015, and RTS,S/AS01 is being rolled out via the Malaria Vaccine Implementation Program (MVIP) by the World Health Organization in Ghana, Malawi, and Kenya.

On the first episode of the Infectious Disease Puscast, Daniel and Sara bring Marc Crislip's well known Puscast back to life, and present a review of the infectious disease literature for the previous two weeks, 4/13 – 4/27/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rabies from an anteater (MMWR) Oral Tebipenem Pivoxil Hydrobromide in Complicated UTI (NEJM) Therapeutic monitoring of vancomycin for serious MRSA infections (IDSA) Time to retire Vancomycin for MRAS Endovascular Infections? (Op Forum Inf Dis) Impact of ID consultation on outcome of patients with enterococcal bacteremia (Op Forum Inf Dis) Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia (JAMA) Effect of Antimicrobial Prophylaxis Duration on Health Care-Associated Infections After Clean Orthopedic Surgery (JAMA) Randomized Clinical Trial Comparing Seven Versus Fourteen Days of Antibiotics for Uncomplicated Gram-Negative Bloodstream Infection (Op Forum Inf Dis) Vehicle Windshield Wiper Fluid as Potential Source of Sporadic Legionnaires' Disease in Commercial Truck Drivers (MMWR) Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis (NEJM) High Prevalence of Plasmodium falciparum K13 Mutations in Rwanda Is Associated With Slow Parasite Clearance After Treatment With Artemether-Lumefantrine (JID) Association of Reduced Long-Lasting Insecticidal Net Efficacy and Pyrethroid Insecticide Resistance With Overexpression of CYP6P4, CYP6P3, and CYP6Z1 in Populations of Anopheles coluzzii From Southeast Côte d'Ivoire (J Inf Dis) Intro music is by Ronald Jenkees Send your questions for Puscast to puscast@microbe.tv

In this week's episode we'll discuss the efficacy of the obinutuzumab-lenalinomide combination in advanced follicular lymphoma, learn more about the underlying mechanisms of anemia in children infected with Plasmodium falciparum, and discuss how granulocyte microvesicles could improve outcomes in septic shock.

The text of this podcast is from the Wikipedia article on malaria, a well-known and terrible tropical disease. For listeners to this podcast who are studying science, this will give you practice pronouncing typical scientific vocabulary. I'll repeat the paragraph three times, and then break it into sentences or shorter phrases so you can practice repeating. Excerpt from:  https://en.wikipedia.org/wiki/MalariaMalaria is caused by single-celled microorganisms of the Plasmodium group. It is spread exclusively through bites of infected Anopheles mosquitoes, according to a 2014 WHO fact sheet. [WHO is the World Health Organization.] The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver where they mature and reproduce. Five species of Plasmodium can infect and be spread by humans. Most deaths are caused by P. falciparum, whereas P. vivax, P. ovale, and P. malariae generally cause a milder form of malaria. The species P. knowlesi rarely causes disease in humans. Malaria is typically diagnosed by the microscopic examination of blood using blood films, or with antigen-based rapid diagnostic tests. Methods that use the polymerase chain reaction to detect the parasite's DNA have been developed, but are not widely used in areas where malaria is common due to their cost and complexity.1. Malaria is caused by single-celled microorganisms of the Plasmodium group. 2. It is spread exclusively through bites of infected Anopheles mosquitoes, according to a 2014 WHO fact sheet. 3. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. 4. The parasites travel to the liver where they mature and reproduce. 5. Five species of Plasmodium can infect and be spread by humans. 6. Most deaths are caused by P. falciparum. 7. Malaria is typically diagnosed by the microscopic examination of blood using blood films…8. or with antigen-based rapid diagnostic tests. 9. Methods that use the polymerase chain reaction to detect the parasite's DNA have been developed…10. but are not widely used in areas where malaria is common due to their cost and complexity.Intro & Outro Music: La Pompe Du Trompe by Shane Ivers - https://www.silvermansound.com

There are five Plasmodium species that cause malaria with the vast majority of reported cases being due to Plasmodium falciparum. Plasmodium vivax is the second most common reported cause of malaria. My guest today says P. vivax infections represent a major unrecognized burden on global health calling it "obscure and insidious" and we'll take a look at why he says this. Joining me today to discuss Plasmodium vivax, it's burden and a new study published in PLoS Medicine is Kevin Baird, PhD. Professor Baird is the head of the Eijkman-Oxford Research Unit in Jakarta, Indonesia and Professor of Malariology, Nuffield Department of Medicine, University of Oxford.

Episode SummaryHope for the future is vital to our makeup as human beings. Often, families, mothers around the world, watch in anguish as their children battle and all to often, succumb to malaria. But there is hope.The new malaria vaccine has already starting bringing this hope to hundreds of thousands of families who otherwise would have despaired at the ravages from the deadly disease that malaria is. Welcome to today's episode of Victory in Mind as we place a spotlight on malaria, highlighting the recently announced major medical breakthrough of a malaria vaccine after 30 years of research.Join me as we root all the way for the success of humanity!TIME-STAMPED SHOW NOTES[00:00:00] Show trailer [00:00:44] Intro music and voice over narration for the show[00:01:19] Introduction to the show [00:01:42] Consider the case of polio and the polio vaccine. [00:02:51] Goal of today's episode. [00:03:13] Why should you or I pay attention to the announcement regarding the malaria vaccine?[00:03:45] So what exactly was the announcement made? [00:04:20] Striking close to home. [00:06:55] Brief history of malaria. [00:08:00] What actually causes malaria? [00:09:00] Some of the stats on Plasmodium falciparum.[00:09:53] So who exactly is risk? [00:10:24] Why does malaria remain a problem? [00:10:46] Numbers don't lie. [00:12:00] Why the big deal then with this malaria vaccine? [00:13:12] Is this vaccine legit? [00:14:08] The future with this malaria vaccine: [00:15:32] Conclusion. Thank you so much for listening. Be sure that you subscribe to this podcast. That way you can automatically receive episodes and share the link. Share so people can liisten and get educated to what's going on around the world and why this malaria vaccine is such a big deal. You can go to our website www.victoryinmind.com for show notes as well as links to download and subscribe. Thanks for staying tuned to Victory in Mind. We appreciate you. I'm your host, Waceke Wambaa thanking you for joining me on our podcast today. Remember you have a future. You have a hope.[00:17:04] Outro music and voice over narration for the showLEAVE SOME FEEDBACKWhat should we talk about next? Please let us know in the comments below.Did you enjoy this episode? If so, please leave a short review. Here's the iTunes/Apple Podcast link: https://podcasts.apple.com/us/podcast/victory-in-mind/id1557591084. Be sure you are subscribed to this podcast so you can automatically receive your episodes!!! MORE INFOIf you'd like to find out more about Waceke visit: www.tataceke.comRESOURCESFor fantastic podcast intro/outro: GNX Productions. Larry "DJ X-Cell" Wall. Djxcell75@gmail.comGorgeous podcast artwork designed by Cameron Ward at www.camwarddesign.com.For voice over services: visit https://tataceke.comResource Articles:https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death Accessed October11, 2021.https://www.who.int/health-topics/malaria#tab=tab_1 Accessed October 11,

Dr Alena Pance has had an incredible career traversing neuroscience, cancer, and tropical parasite research. She has always had a focus on transcriptional regulation and it was incredible hearing about how she adapted to these very different fields. Alena was very honest in this interview about her two very different experiences of having children in research. It was very interesting to hear how these fed into policy changes that women on the Wellcome Genome Campus were driving and, although there is still work to be done, how much better these women made it for the parents coming after them. Some Resources! Alenas Sanger Page: https://www.sanger.ac.uk/person/pance-alena/ Alenas LinkedIn: https://www.linkedin.com/in/alena-pance-a4930620/ Alenas ResearchGate profile https://www.researchgate.net/profile/Alena-Pance Some of her most recent papers include: Pance, A. The Stem Cell Revolution Revealing Protozoan Parasites' Secrets and Paving the Way towards Vaccine Development. Vaccines 9, 105 (2021). https://www.mdpi.com/2076-393X/9/2/105/htm Pance, A. Diversify and Conquer: The Vaccine Escapism of Plasmodium falciparum. Microorganisms 8, 1748 (2020). https://www.mdpi.com/2076-2607/8/11/1748/htm And one of her landmark research papers: Bentrari, F., Chantôme, A., Knights, A., Jeannin, J.-F. & Pance, A. Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1. Nucleic Acids Res. 43, 9757–9765 (2015). https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158238 https://academic.oup.com/nar/article/43/20/9757/1400090 She's also been part of a great series called as part of public engagement called Talking Cells taking you through the life of a cell. I've linked below “The Life of a Cell”, “The Odd Neighbor Best”, and “A Tumultuous Affair”: https://www.youtube.com/watch?v=pIHqaCm7xZo https://www.youtube.com/watch?v=5SI0hisPQgw https://www.youtube.com/watch?v=rZKsQ_vDx0I Music: 'Lion' by Sapajou Free download: bit.ly/3q6w8mW --- Send in a voice message: https://anchor.fm/decoding-life-pod/message