Podcasts about Yale University

There is so much we don't know about our universe. But our curiosity about the unknown shouldn't blind us to the incredible progress we have made in cosmology over the last century. We know the universe is big, expanding, and accelerating. Modern cosmologists are using unprecedentedly precise datasets to uncover more details about the evolution and structure of galaxies and the distribution and nature of dark matter. Priya Natarajan is a cosmologist working at the interface of data, theory, and simulation. We talk about the state of modern cosmology, and how tools like gravitational lensing are providing us with detailed views of what's happening in the distant universe.Support Mindscape on Patreon.Priya Natarajan received her Ph.D. in astrophysics from the University of Cambridge. She is currently professor of astronomy at Yale University, the Sophie and Tycho Brahe Professor at the Niels Bohr Institute of the University of Copenhagen, and an honorary professor for life at the University of Delhi, India. She is an Affiliate at the Black Hole Initiative at Harvard University and an Associate Member of the Center for Computational Astrophysics at the Flatiron Institute in New York. She is a frequent contributor to the New York Review of Books and other publications. Among her awards are a Guggenheim Fellowship, the India Abroad Foundation's “Face of the Future” Award, and an India Empire NRI award for Achievement in the Sciences. She is the author of Mapping the Heavens: The Radical Scientific Ideas That Reveal the Cosmos.Web siteYale web pageGoogle Scholar publicationsArticles at the New York Review of BooksWikipediaTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Jon Lieff is a neuropsychiatrist with a Bachelor of Arts in Mathematics from Yale University and a Doctorate in Medicine from Harvard Medical School. You can check out his newest book " The Secret Language of Cells" which is available now.

Pastor Aaron moderates a panel of four current missions partners of Grace who also grew up at Grace Church.Missionaries:Jenna DeJesus, serves in Chi Alpha Christian Fellowship at Yale University, alongside her husband, Stevens. You can find out more about them in a longer interview we did with them here.Phil and Renee Remmers serve on the the Robert Morrison Project, a non profit, non- denominational organization dedicated to legally translating and publishing reformed Christian literature in Asia.David and Susan Parshall have served in Overseas Missionary Fellowship, spreading the gospel to the Uyghur people of China. They currently serve in Nepal with missionaries sent out from China.Nancy Fritz works with Anda Leadership and is also part of a global network of missionaries who train church workers how to run children's ministry. Resources:Class "Perspectives on the World Christian Movement"Missions by Andy JohnsonThe Call: Finding and Fulfilling the Essential Purpose of Your Life by Os GuinnessChi Alpha "We Live Missions" PodcastJohn Piper's Missionary Biographies 

A virtual event presentation by Professor Paul Franks ABOUT THE EVENT: What is the legacy of German Judaism, and what can it still offer us today? German Judaism began with Moses Mendelssohn's controversial German translation of the Humash in 1783, and ended with the Nazi pogrom of November 1938. The best known slogan of the Torah-true wing of German Judaism is “Torah im derekh erets” (“Torah with the way of the land”). But this slogan is often misunderstood as nothing more than an educational philosophy that came in one flavor. In fact, it is an ideal of humanity articulated, in several competing versions, in the context of the quest for Jewish civil rights. The German-Jewish tradition raises vital questions that remain relevant today: What is the mission of Jews within civil society? What makes a Jewish community Jewish? What role should Jews play within the ongoing struggle for social justice and civil rights? ABOUT THE SPEAKER: Paul Franks is the Robert F. and Patricia Ross Weis Professor of Philosophy and Judaic Studies at Yale University. He was educated at Gateshead Yeshiva; Balliol College, Oxford; and Harvard University. Before arriving at Yale in 2011, he was the inaugural holder of the Jerahmiel S. and Carole S. Grafstein Chair in Jewish Philosophy at the University of Toronto. He has also taught at University of Michigan, Indiana University Bloomington, University of Notre Dame, and University of Chicago, and he has given shiurim at synagogues and Jewish community centers throughout Britain, Israel, and North America. Paul works at the intersection of the Jewish and German philosophical traditions, specializing in Kantian and post-Kantian metaphysics, epistemology, and philosophy of the humanities and social sciences. He is the translator and annotator, with Michael L. Morgan, of Franz Rosenzweig, Philosophical and Theological Writings (Hackett, 2000); and he is the author of All or Nothing: Systematicity, Transcendental Arguments, and Skepticism in German Idealism (Harvard, 2005), as well as over fifty academic articles. He is currently writing, with his collaborator Morgan, an ambitious survey that will reveal the dynamic interaction between Jewish philosophy and modern European philosophy from Luria to Levinas, and he is also working on a monograph on Kant's metaphysical and epistemological legacy. -- DONATE: www.bit.ly/1NmpbsP​​​​​​​ For podcasts of VBM lectures, GO HERE: www.valleybeitmidrash.org/learning-library/ www.facebook.com/valleybeitmi...​ Become a member today, starting at just $18 per month! Click the link to see our membership options: www.valleybeitmidrash.org/become-a-member/

In the middle of the pandemic, Dr. Nicholas Christakis released a sweeping book, called “Apollo's Arrow: The Profound and Enduring Impact of Coronavirus on the Way We Live.” In it, he drew on scientific, medical, and sociological research, and assessed the transmission of the virus, responses worldwide, and prognosis for the pandemic's end, including some […]

In the middle of the pandemic, Dr. Nicholas Christakis released a sweeping book, called “Apollo's Arrow: The Profound and Enduring Impact of Coronavirus on the Way We Live”. In it, he drew on scientific, medical, and sociological research, and assessed the transmission of the virus, responses worldwide, and prognosis for the pandemic's end, including some bold predictions. The paperback edition is just out with some new material.

Dorian Webb the founder of Dorian Webb Lifestyle, creates intentional semiprecious and precious jewelry, artwork, and bespoke home décor that celebrates women, the beauty of connection, and African American culture. The company, which Dorian began while studying at Yale University, found early success at its first trade show where Neiman Marcus purchased the line for […]

In this episode, Jeremi and Zachary talk with special guest Dr. Mark Atwood Lawrence about the Vietnam War and its continuing legacies in American society, global policy, as well as recent similar conflicts in Afghanistan and Iraq. Zachary sets the scene with his poem, “It is Hard to Build Utopias”. Mark Atwood Lawrence is Director of the LBJ Presidential Library and Museum in Austin, Texas. Until January 2020, he taught history at UT-Austin, where his classes focused on American and international history. Lawrence is author of Assuming the Burden: Europe and the American Commitment to War in Vietnam, The Vietnam War: A Concise International History, and, this fall, The End of Ambition: The United States and the Third World in the Vietnam Era, as well as several edited books and numerous articles, chapters, and reviews on various aspects of the history of U.S. foreign relations. Lawrence has held the Cassius Marcellus Clay Fellowship at Yale University (2006-2008) and the Stanley Kaplan Visiting Professorship in American Foreign Policy at Williams College (2011-2012). He earned his BA from Stanford University and his PhD from Yale University. This episode of This is Democracy was mixed and mastered by Ean Herrera.

"Our Happy Divorce" authors, Nikki DeBartolo and Benjamin Heldfond slid into the diner booth with me this week. Divorce is never easy but these two have figured out a way to make it work for their son Asher. We started our conversation talking about how Ben and Nikki met, when the sparks flew, and what brought them from San Francisco to Tampa, Florida. Making friends in a new city is hard and resentment is a tough emotion to shake when it starts building. I really appreciate the candor and self-awareness they both showed when owning how the years leading up to the divorce and the few after could have been handled better. We also talked about how they worked through the popular, though flawed, rationale many unhappy couples have: Stay together for the kids. We ended talking about the importance of counseling, the beauty of an open mind, and the power of clarity in communication. This was filled with just the right amount of couple bantering and deep-hitting realities. Excited for you to hear it!      About the Guest:  From weeknight dinners and homework sessions with their son to Christmas card photos and vacations, Nikki DeBartolo and Benjamin Heldfond have created a tight-knit, enviable family. They work and play well together, from the smallest daily tasks to the biggest life events—and it only took a divorce to get them there. Though their marriage has been over for nearly a decade, they still share a happy life with each other and their son Asher, along with their new amazing spouses and children. Ben and Nikki had hoped their wedding would start their happily ever after—but seven years, one child, and countless financial and familial entanglements later, their I do-s had turned into We can't-s. Armed with their fierce love for their son and a desire to give him the best, they realized they needed to find an alternative to the seemingly inevitable toxic divorce that loomed over their lives. Refusing to participate in the standard litigious legal divorce process, they devised a new strategy and worked to confront their hurt feelings and fragile egos head-on. Committed to putting Asher's needs first in every decision, they helped each other heal and build a future. Their happily blended family today is a testament to their commitment to a few core principles and their incredible son—during the divorce and beyond. In their stunning book "Our Happy Divorce," Ben and Nikki elaborate on the difficulties of their divorce experience, their individual pains and triumphs, and their unique approach to relationships and blended families. Their story is sure to inspire others to pursue something few believe possible…a happy divorce.   Connect with Ben and Nikki and learn more: https://www.amazon.com/Our-Happy-Divorce-Marriage-Together/dp/1631779974/ref=sr_1_1?keywords=Our+Happy+Divorce&qid=1568927277&sr=8-1 (Link to their book on Amazon) @ourhappydivorce on Instgram About the Host:  Friends! Here's a somewhat stuffy bio of me:   I am an author, professional speaker, coach, host, and entrepreneur. My first book, Leading Imperfectly: The value of being authentic for leaders, professionals, and human beings, is available wherever people buy books. I speak internationally to willing and unwilling attendees about authenticity, vulnerability, and leadership. My clients include American Express, General Electric (GE), Accenture, Yale University, The Ohio State University, and many others. As a speaker, I am doing the two things I loves the most: making people think and making people laugh!  I host my own events multiple times a year. They are 2-day events called Living Imperfectly Live (and sometimes they are 1-day virtual events). They are a space where humans from every walk of life can come together to be part of a community on the pursuit of badassery. The goal is to help attendees start living the life we say we want...

"The problem is ourselves." Timothy Snyder describes why the challenges of our democracies are not so much political figures like Trump, but ourselves as citizens. Snyder says it's about breaking down social barriers while addressing structural political problems like voter suppression and the manipulation of the electoral college. "A failed coup attempt is a rehearsal for a later coup." Timothy Snyder teaches history at Yale University. His book, "On Tyranny," has been translated into more than 40 languages and sold nearly half a million copies in the U.S. alone. It was published in 2021 by Ten Speed Press in an edition illustrated by Nora Krug.

The United States is responding to an influx of refugees from Afghanistan following the Taliban's takeover of the country. But what happens after they arrive in our state?This week, we take a look at the immigration process for refugees. We'll hear from two immigration experts about how we can best support new migrants and what research tells us about their ability to thrive in America. And a housing advocate breaks down zoning policy in Connecticut and how it's making housing more expensive. Guests: Hossna Samadi - Afghan migrant who moved to Connecticut with her family in 2016. She now works with Integrated Refugee and Immigrant Services and Sanctuary Kitchen in New Haven. Martine Dherte - Refugee Services Program Manager at the Connecticut Institute for Refugees and Immigrants. Salma Mousa - Assistant Professor of Political Science at Yale University. Sara Bronin - Professor of City and Regional Planning at Cornell University, and founder and lead organizer of Desegregate Connecticut. She was recently nominated by President Biden to chair the Advisory Council on Historic Preservation. Disrupted is produced by James Szkobel-Wolff, Zshekinah Collier, and Catie Talarski. Our interns are Abe Levine, and Dylan Reyes. See omnystudio.com/listener for privacy information.

We loved this book! If you're also a fan of Practical Magic, Hocus Pocus, and books both spooky and pretty, Lana's newest work, Payback's A Witch, is a beautiful, fun, sexy rom com for your October. We discuss how to know when you've written *just* enough description (and the fact that many readers don't want to smell characters), writing villains we can't stand (who are just charming enough to be believable), and the creation of a magical system (which is somehow, at once, beautiful, believable, and escapist). Lana studied psychology and literature at Yale University and law at Boston University. She is a graduate of the Emerson College publishing and writing program and the author of YA novels Wicked Like a Wildfire, Fierce Like a Firestorm, Blood Countess, the forthcoming Poison Priestess, and the adult rom-com, Payback's A Witch, from Berkley Books. Lana was born in Serbia and lived in Bulgaria, Hungary, and Romania before moving to the United States. She lives in Chicago with her family.

Stacie Wong is a Principal at GLUCK+. Named by Fast Company as a top 10 most innovative companies in architecture, the firm is recognized for Architect Led Design Build. Stacie's considerable design and construction experience began 26 years ago with the Yale Building Project's design-build of a single-family residence in New Haven. Ever since, she has been involved in educational, commercial and residential work across the United States. Stacie brings expertise in leading strategic planning, research, programming, and community stakeholder engagement with private and public institutional clients, as well as stewarding the design and construction for the successful completion of many technically complex projects. She has been an advocate for architects' involvement in construction to increase their agency in the building process and impact on the design of the physical environment, including features in Metropolis Magazine, Wallpaper* and Architectural Design (UK). Notable award-winning projects include ONStage at Kaufman Astoria Studios in New York City, Pilkey Lab, a LEED Gold science research building for Duke University Marine Laboratory on their coastal campus; Artist Retreat in Upstate New York; and The East Harlem School in New York City. Current projects in progress include Van Sinderen Plaza, affordable housing in East New York and City Seminary of New York's campus in Harlem. Stacie received her Bachelor of Arts in Architecture from the University of California at Berkeley and a Master of Architecture from Yale University.   In this episode we talk about: Stacie's desire to become a complete architect, and know how a building actually gets put together, led to her interest in design-build projects How GLUCK+ scaled up its design-build work to include both single-family residences and public institutional work Stacie's experience working as a Superintendent on a construction site Advice for emerging professionals on navigating construction sites and Construction Administration  Why there's no shame in not knowing everything, and the best way to learn How GLUCK+ is set up so everyone works on both the design and construction side Why there is less liability in design-build than people may think - We want to hear from you! Please send your feedback to hello@designvoicepodcast.com and follow the show on Instagram at https://www.instagram.com/designvoicepodcast.

What has patriotism meant over time, and how has civil debate shaped it? We hosted a discussion of that question last week featuring philosopher Steven Smith of Yale University, who shared insight from his new book, Reclaiming Patriotism in an Age of Extremes. He was joined by historians Allen Guelzo of Princeton University and Sophia Rosenfeld of the University of Pennsylvania. They explored some of the key episodes of patriotism and dissent throughout American history—from the Revolution through the Founding and the Civil War to today. Jeffrey Rosen, president and CEO of the National Constitution Center, moderated. This panel was streamed live on October 13, 2021. 

Building Sustained Giving, Continuous Growth, and an Engaged, Loyal Donor Base: Don't Make It About Money There are hundreds of millions of dollars in philanthropic funds which lie on the sidelines each year. This is over and above all the millions currently in donor-advised holdings. Accessing these funds is possible for any worthy charitable organization. To do so, nonprofit leaders must first adopt the right mindset, as being truly successful in fundraising is 90% thinking and only 10% doing. Larry C. Johnson is an internationally recognized philanthropy and fundraising thought leader, Larry trains the staff and volunteers of worthy causes to achieve real impact through the creation of reliable, growing revenue streams. He emphasizes principles before methods as the key to long-lasting success. He stresses the simple, the practical, and the joyful. Larry is the Founder of The Eight Principles, the premier brand for educational products and services in relational fundraising and philanthropy. The Eight Principles provides digital education, live workshops, and structured coaching to nonprofit organizations. Author of the award-winning book, The Eight Principles of Sustainable Fundraising, AFP named Larry Outstanding Development Executive in 2010. The Wall Street Business Network ranks him in the Top 15 Fundraising Consultants in the USA. Larry is a graduate of Yale University. Larry speaks widely and serves on numerous nonprofit and corporate boards, including The Philanthropy Council of The Carter Center, the philanthropy of the 39th President of the United States. Learn more about your ad choices. Visit megaphone.fm/adchoices

Following a "small but successful" 10 Days in 2006, Jonathan is inspired while at a conference at Yale University to enter a season of extended fasting. During the fast, he heard the Lord ask him to "call 120 to pray for 10 Days leading up to Pentecost." This new direction from the Lord led to an amazing faith adventure. Unexpectedly, the emerging 10 Days team began to converge with significant threads of revival and missions history. Ultimately, this led to the first 10 Days retreat in Northfield, MA in 2007 at an enormous, empty campus founded by evangelist DL Moody. This "revival lab" experience was full of firsts. This was the first time they saw what could happen when believers "stopped everything" to seek God for 10 Days. For Jonathan, this time touched on an even deeper desire--it was his first time experiencing what it feels like when believers are "one as the Father and Son are one", a small but significant measure of John 17 unity. This is the fourth installment in a multi-part series of interviews telling the story of 10 Days in depth from the perspective of the founder, Jonathan Friz, interviewed by 10 Days board member Gregg Healey.  While many people have heard elements of the story of 10 Days, this is an in depth retelling that includes many stories that have never been shared before publicly.  You'll hear it all--from amazing victories to dramatic and painful failures.  Jonathan and Gregg are good friends and it comes through in the playful and fun conversational style of the interviews. Support this podcast

Today, we hear about human happiness from two of the world's foremost researchers on the subject: Dr. Laurie Santos and Dr. Arthur Brooks. Dr. Santos hosts The Happiness Lab, a podcast “that will forever alter the way you think about happiness.” She's also a Professor of Psychology at Yale University and teacher of one of the most popular classes ever in Yale history: The Happiness Class, which tries to give students the keys to happiness and satisfaction. Dr. Brooks is a Harvard professor, social scientist, prolific bestselling author, and columnist at The Atlantic. Learn more: Laurie Santos The Happiness Lab podcast Arthur C. Brooks   Subscribe to Stories of Impact wherever you listen to podcasts Facebook, Twitter, Instagram, YouTube Comments, questions and suggestions info@storiesofimpact.org Supported by Templeton World Charity Foundation

Colleges and universities all over the United States are facing a wave of students suffering from depression and anxiety heightened by the last year and a half of the pandemic.  Dr. Jud Brewer says there are things everyone can do to be more mindful, to break bad habits, and to be happier. Brewer is the Director of Research and Innovation at the Mindfulness Center and associate professor in Behavioral and Social Sciences at the School of Public Health and Psychiatry at the School of Medicine at Brown University.  He is also a research affiliate at MIT.  Before that, he held research and teaching positions at Yale University and the University of Massachusetts' Center for Mindfulness.  Brewer is a New York Times best-selling author of “Unwinding Anxiety: New Science Shows How to Break the Cycles of Worry and Fear to Heal Your Mind” (March 2021).  He is an addiction psychiatrist and an internationally known expert in mindfulness training for treating addictions.  Based on the success of these programs in the lab, he co-founded MindSciences, Inc. to create app-based digital therapeutic versions of these programs for a wider audience, working with individuals, corporations, and hospital systems to put effective, evidence-based behavior change guidance in the hands of people struggling with unwanted behaviors and “everyday addictions.” See omnystudio.com/listener for privacy information.

Please join author Khurram Nasir and Associate Editor Sandeep Das as they discuss the article "Social Vulnerability and Premature Cardiovascular Mortality Among US Counties, 2014-2018." Dr. Carolyn Lam: Welcome to Circulation on the Run your weekly podcast, summary, and backstage pass to the journal and its editors. We're your co-hosts, I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center in Duke-National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor, Director of the Poly Heart Center, VCU Health in Richmond, Virginia. Dr. Carolyn Lam: Greg, I'm really excited about today's feature discussion. It's really meaningful on so many levels. It discusses social vulnerability. In other words, social determinants of health and its association with premature cardiovascular mortality among US counties. Now, even as an ex-US person I learned a lot, so everyone is going to want to listen in. But now let's start with going through some exciting papers in today's issue, shall we? Dr. Greg Hundley: You bet Carolyn. So, I'm going to grab a cup of coffee and we'll get started with the first article. And really gets into the world of cardiovascular risk and prostate cancer management. Dr. Greg Hundley: So, Carolyn in the light of improved prostate cancer survivorship, and the competing risk of cardiovascular disease, there's an ongoing need for rigorous cardio oncology clinical trials. As you probably know, androgen deprivation therapy is a cornerstone of prostate cancer therapy. Through different pituitary gonadotropin releasing hormone receptor mediated mechanisms both GnRH agonists, as well as antagonists, either indirectly or directly inhibit luteinizing hormone secretion, consequently inhibiting testosterone production. These GnRH agonists are the most commonly prescribed form of androgen deprivation therapy with only 3 to 4% of patients receiving a GnRH antagonist. Dr. Greg Hundley: So, Carolyn the relative cardiovascular safety of gonadotropin releasing hormone antagonists compared with gonadotropin releasing hormone agonists in men with prostate cancer and known atherosclerotic cardiovascular disease remains somewhat controversial. And therefore these authors led by Dr. Renato Lopes from both Brazil, as well as the Duke University Medical Center in Durham, conducted an international multicenter, prospective randomized open label trial, and men with prostate cancer and concomitant atherosclerotic cardiovascular disease were randomized one to receive gonadotropin releasing hormone, antagonist degarelix or the gonadotropin releasing hormone, agonist leuprolide for 12 months and the primary outcome was time to first educate major adverse cardiovascular event that combined the endpoints of composite death MI and stroke over these 12 months. Dr. Carolyn Lam: Nice Greg, and what did they find? Dr. Greg Hundley: Right Carolyn, due to slower than projected enrollment and fewer than projected primary outcome events enrollment was stopped before the 900 plan participants were accrued from May 3rd, 2016 to April 2020, a total of 545 patients from 113 sites across 12 countries were randomized. Baseline characteristics were really balanced between the two study groups. Now Mace occurred in 5.5% of the patients assigned to degarelix and 4.1% assigned to leuprolide and so in summary, Carolyn, this pronounced study is the first international randomized clinical trial to prospectively compare the cardiovascular safety of a gonadotropin releasing hormone antagonist as well as agonist in patients with prostate cancer. And the study was terminated prematurely due to smaller than planned number of participants and events. And so no difference in mace at one year was noted between the two groups and this pronounced study really provides a model for interdisciplinary collaboration between urologists, oncologists and cardiologist with a sheer goal of evaluating the impact of cancer therapies on cardiovascular outcomes. Dr. Carolyn Lam: That's so cool, Greg. I heard the presentation of these results at the ESC by Dr. Renato Lopes and it's a really cool and important study, but a paper I want to present is an analysis from Emperor preserved on inpatient and outpatient heart failure events. Dr. Greg Hundley: Great. Carolyn, so remind us, what did the Emperor preserved trial show? Dr. Carolyn Lam: Emperor preserved showed that in patients with heart failure and preserved ejection fraction empagliflozin reduce the primary endpoint of cardiovascular death or hospitalization for heart failure, primarily related to a lower risk of hospitalizations for heart failure. Greg you're smiling, because you can see me beaming because we finally have a robustly positive outcomes trial in have pep in this trial. Nonetheless in the current analysis, Dr. Milton Packer from Baylor Heart and Vascular Institute and others used prospectively collected information on inpatient and outpatient events, reflecting worsening heart failure, and pre specified their analysis in individual and composite end points. Dr. Greg Hundley: I've been in suspense here. What did they find? Dr. Carolyn Lam: Empagliflozin reduced the risk of severe hospitalizations as reflected by admissions requiring the use of ionotropic or vasopressor drugs and the need for intensive care. Empagliflozin also reduce the risk of outpatient worsening heart failure events, including the need for urgent care visits, diuretic, intensification, and unfavorable changes in functional class. So, basically benefit across the spectrum. Furthermore, because there's controversy about the effect across the spectrum of ejection fraction. The benefit on total heart failure hospitalizations was found to be similar in patients with an ejection fraction of above 40, but less than 50% and between 50 to 60%, although it was attenuated at the higher ejection fractions and we'll hear a lot of discussions about this.   Dr. Greg Hundley: Wow, Carolyn. Just more information that keeps coming out about SGLT-2 inhibition. My next paper comes from the world of preclinical science and angiogenesis is a dynamic process, involves expansion of a preexisting vascular network that can incur in a number of physiologic and pathologic settings. But despite its importance, the origin of the new angiogenesis vasculature is really poorly defined in particular, the primary subtype of endothelial cells, whether they be capillary, Venus or arterial that might be driving, this process really remains undefined. These authors led by Dr. Michael Simmons at Yale University school of medicine, fate mapped endothelial cells using genetic markers specific to arterial, Venus and capillary cells. Dr. Carolyn Lam: What did they find Greg? Dr. Greg Hundley: This team study results found that Venus endothelial cells were the primary endothelial subtype responsible for the normal expansion of vascular networks, formation of arterial, venous malformation, and pathologic angiogenesis. And these observations highlight the central role of the Venus endothelium in normal development and disease pathogenesis. Dr. Carolyn Lam: Wow. That's really interesting. I don't think I've ever really paid attention to that bit. Venus endothelium. Thank you for that. Now what else is in today's issue? Well, there's an exchange of letters between Doctors Zhang and Liao regarding the article anti hypertrophic memory after regression of exercise induced physiologic, myocardial hypertrophy is mediated by the long noncoding RNA M heart 779, then ECG Challenge by Dr. Ahmed on challenges of interpreting smart watch and implantable loop recorder, tracings. There's cardiology news by Tracy Hampton and Highlights from the Circulation Family of journals by Sara O'Brien. These regular articles are just really worth a read. You learn so much from just these short lovely summaries. There's On My Mind paper by Dr. Meyer on a targeted treatment opportunity for taking advantage of diastolic tone. And there's also a Research Letter by Dr. Brozovich on a rat model of heart failure with preserved ejection fraction changes in contractile proteins, regulating calcium cycling and vascular reactivity. Dr. Greg Hundley: These journal issues, there's so much information. I'm in a close out with an in depth piece from professor entitled antithrombotic therapy in patients undergoing transcatheter interventions for structural heart disease. I really look forward to your feature discussion on the social vulnerability and premature cardiovascular mortality in US countries. Dr. Carolyn Lam: Thanks Greg. It's good. Dr. Carolyn Lam: Today's feature discussion focuses on an extremely important topic of social vulnerability and premature cardiovascular mortality. So pleased to have the corresponding author of the feature paper, Dr. Khurram Nasir from Houston Methodist and Dr. Alana Morris, who is the editorialist for this paper. And she's joining us from Emory University in Atlanta, Georgia. So thank you both of you for joining and Alana if you don't mind, I'm going to borrow some of the words from your really-excellent editorial to bring us into the discussion. You very nicely brought up that early race and ethnic disparities and a death toll from COVID 19 really, laid the foundation for us having Frank conversations about vulnerable populations and has really brought to light social determinant of health and social economic inequality as risk factors. Now that's, COVID 19. And frankly, if we put everything in a global view of what kills most of us, it's still cardiovascular disease, which is why this paper is just so important, but current recognizing I'm not from the US, lots of our audience are not from the US. Could you please walk us through what your paper looked at and what it means? Dr. Khurram Nasir: Sure. Klan, thank you so much for having us today and what a wonderful editorial by Dr. Morris on this. As you pointed out about the COVID challenges, we were all touched by the significant disparities, really in a one of the lifetime crisis, such as COVID. But the reality is that even in times of calm the benefits, for example, cardiovascular disease prevention access have not been shared equally among vulnerable groups. So I'm a preventive cardiologist, and it gives me immense pride that despite being the number one cause of morbidity mortality for so long as a cardiology community, we have made significant strides over the last three decades, cutting into our losses. And if you look at the trends it's appeared and I'm very hopeful that we'll soon be losing the number one killer tag in US. At the same time we are seeing that those cuts are being lost, especially in the young individuals. Dr. Khurram Nasir: And at one point while we celebrate these decline. But the thing that bothers many of us that unfortunately these gains have not been equal, especially for our more vulnerable patients. And apart from the well documented, I think racial disparities that we all know and are becoming more aware. I think health disparities also form across various fourth lines and I believe the deepest and more persistent divides is around income. And you can even go a step further in US, unfortunately for our international group is unfortunate fact that in US, your zip code may hold more sway than your genetic code. And an example was made famous in St. Louis, Missouri Del marble award, which is known as the Delmer divide, a title that was made famous by a four minute BBC documentary that showed, that a sharp dividing line between the poor predominantly African American neighborhoods in the north and more affluent, largely white neighborhood in the south with health falling across this divide. Dr. Khurram Nasir: And in our practice, we see this phenomenon clearly in our own backyard. So, inspired by this sterling. We wanted to determine that a mirror geographical measure, where we can get insights of conditions where people live, learn, work, play, grow, and age, and commonly now known as the social determinants of health. Can that explain some of these rising risks, especially in the premature cardiovascular disease. So to design this study, we reached out to the CDC social vulnerable, the index that has been created that ranks communities and zip codes based on 15 factors across food domains, socioeconomic status, household composition of disability, that in includes single parents, elderly or children, minority status and language and housing type and transportation, all of them are put together and for each census. And then eventually at the county level, you can classify what their social vulnerability is. And as you know, this was really developed in to identify places where in times of disaster and emergencies, you can focus a little bit more, but we thought about how do we connect this to, for example, our data on mortality from CDC wonder. Dr. Khurram Nasir: And once we did that, we found very interesting patterns that across the scale social vulnerability, there is a risk dose dependent fashion and the age adjusted mortality rates for premature cardiovascular disease, which we define as less than 65, went from the least vulnerable and became the worst across the most vulnerable. At the same time, we also found this double jeopardy issues where this association was varied by race, gender, and ruler. And what we found that specifically Non-Hispanic lack individuals were more likely for certain types of cardiovascular, premature, such as stroke and heart failure, mortality, as compared to the rest, even if you were from the least vulnerable to the most women also unfortunately had a twofold higher risk of CBD mortality. And what is becoming clearly this whole ruler urban that a two to five fold risk of CBD mortality was seen among the least vulnerable. So this is in just the motive of our study, what we did and what we found. Dr. Carolyn Lam: That is so wonderful. Thank you for setting the context and then just to reiterate, so this was all within the US. Alana, could you maybe help frame how important these findings are for us? Dr. Alana Morris: Yes. I think that this analysis is so important, particularly within the context of some of the things that we see happening politically in our country and our landscape right now. And I think we tried to touch on some of those issues in the editorial. Again, I think that the COVID 19 pandemic, if you want to put that against this landscape has really brought into the forefront of our minds, this issue of disparities. Of course, there are many of us who have been thinking about researching and writing about disparities for a long time, but the issue of disparities really, came into the public mindset with the COVID 19 pandemic. The question now is how do we address these as we go forward? And what we're seeing politically is this question of how do we address inequalities that have been present for really since the beginning of time and maybe are widening and perhaps threaten many of the advances that we've made in terms of cardiovascular disease, morbidity, and mortality. Dr. Alana Morris: I think we have to think about in the US, universal healthcare coverage, because we have to be able to prevent disease and treat disease. And as current addressed, there are neighborhood zip codes where people not only don't have access to healthcare, but they don't even have access to the ability to promote health. They don't have access to things like parks, where they can exercise. They don't have access to healthy foods or grocery stores and in a country like the United States where there's so much wealth, you need to think about the fact that certain individuals, don't have the ability to access a grocery store, to access healthy food. It's just really striking and mind boggling that we have this, the difference in rural versus urban locations where some of our US residents, unfortunately don't have access to primary care clinicians, certainly not specialty clinicians is really very mind boggling. And we've seen this play out with the pandemic, but hopefully once we get past the COVID 19 pandemic, we still have to come back to a place where again, we're taking care of not only preventives or services to prevent the onset of cardiovascular disease, but certainly once people are diagnosed with cardiovascular disease, we want to get them access to specialty care. So we have to think as a community, how do we prevent disease, but also treat disease once disease is diagnosed within our country.   Dr. Carolyn Lam: What you just said about the zip code being more powerful about, than the genetic code, that's like a quotable code. It's incredible. And for those of us coming outside of the US, we don't even realize how much that plays a role, even just within the US. But now let's get to exact point that Alana pointed out, which is what are the next steps. And could you maybe suggest Khurram, and Alana maybe come first, but what's the one thing you want to get out or the one next thing that should happen after this Dr. Alanna Morris: We put a figure in to the editorial that I think really gets to the heart of the matter, I think that those of us who are in healthcare or those of us who think about public health really would ask the question of, why in a country that has as much wealth as the United States, do we not have universal healthcare, most countries across the world that are in an economic position similar to the United States do have universal healthcare coverage for their residents. And you see much better statistics in terms of longevity for their residents as compared to what we have in the United States. And what you see when you look at the United States is that where there is the most vulnerable residents as per analysis identifies those states are the ones that actually don't have, Medicaid expansion. Dr. Alanna Morris: They don't have a safety net for their residents. And so there's really contrast and this disparity that just does not make sense. It does not make sense where there are residents in the United States, which need the most help and they just don't have it. They just are not able to get access to preventive services as well as diagnostic services. And it really just doesn't make sense what we're doing in the United States, in my humble opinion. And I think in the humble opinion of many of us who want to take care of patients, but just cannot, Kern and I both practice in states where this is an issue. And I think that's one big driver. But again, I think when we also think about the built environment in the US and how we think about promoting health and how we talk to patients, when we talk about individuals in the US, we try to give them advice about therapeutic lifestyle changes, how to exercise, how to eat healthy, to prevent disease. That's easier for certain individuals as compared to others, depending upon where you live, depending upon those five digits that make up your zip code. So if we really want our residents to be healthy, we have to create an environment that enables them to do that. Dr. Carolyn Lam: Wow, thank you very much. And as I let Khurram have the final words even about where you think mixed research should be. I just want to highlight that incredible figure from your editorial Alana. I mean, it is really started, there are three panels to it, everyone. The first one chose the social vulnerability index, the second, the premature cardiovascular disease mortality, and then the third, the status of Medicaid expansion. And you can see the colors are just vivid in, how it all makes sense and goes together. So pick up our journal and have a look, but then finally Khurram? Dr. Khurram Nasir: So, Alana, your figure was fantastic and so much add perspective to our findings. As you were saying, it took me back to 35 years back when, where we are before Medicare disparities, even in access to hospitals were dramatic. So where we practice in the south one third of the hospitals would not admit African Americans even for emergency. Now, this is where the policy comes in and suddenly in 1965 using the carrot of Medicare dollars, the federal government virtually ended the practice of racially segregating patients, doctors, and medical staffs, blood supplies so that is the direction that we need to go from the policy perspective and trying to affect the upstream determinants. Now moving forward, as I think more, and especially as a physician, I think while the census level measures are extremely useful to help refine these policy and focus programs in vulnerable areas. Dr. Khurram Nasir: I also think that there is a parallel need to start focusing on similar efforts at the individual level. The first thing is how do we even identify social determinants at this patient level? Are there three main categories, income, education, possibly healthcare, but I think that we need to broaden this. And in the past we have been challenged because we didn't have a set of consensus of the defined SDUH framework. But thankfully now in 2021, we have the healthy people, 2020. Actually for international community, the WHO there is a WHO framework of identifying SDOH at an individual level and in US a more comprehensive Kaiser family foundation. And not only that, we looked at superficially broadly, but we have to go deeper beyond these components of economic instability, education, housing, social context on healthcare beyond insurance, and even food. Dr. Khurram Nasir: For example, income and employment are predominant pillars of income stability, but it may not capture the full picture. For example, difficulty paying bills out of pocket cost and death related to medical care, same in education, where we captured the highest degree, but issues around health and digital literacy and language proficiency may be even more important. So not only we have to broaden the scope, but we have to go in depth. And thirdly, what I've realized from these kind of studies that we have to go a step further, that social disparities don't occur in silos. And we have to look at the aggregated information. And maybe it's time to potentially learn from advances in genetics, in what we have learned that manifestation of disease, especially cardio metabolic rather than being influenced by few major genes is manifested secondary to multiple interacting genes. So can we create similar to a poly genetic risk score, which is an aggregation of genetic smaller risk to a relevant something similar called poly social risk score. Dr. Khurram Nasir: Now, this is an area that our group has been extensively working. And over the last 12 months, we have tried to construct a comprehensive poly social risk score at an individual level based on almost about 50 sub components of the social determinants. And we have suddenly finding very interesting associations with premature CAD stroke. Almost one in two young individuals with stroke, have the worst poly social risk code at the individual level. I think so the next steps will be definitely validation of this tool, incorporation in practice, whether it's adoption and effective interventions can be tied. But the final thing, what I truly want to say is that I'm hopeful that these efforts, the census level at an individual level, at a societal level and the health system are waking up to the importance of social determinants that we can think outside the box and have strong community partnerships. Multi Pro strategies driven largely by social economic environmental factors. So we can all make a lead towards the mission of achieving social justice and equity that eventually cascades through the health system and beyond. So we had enough time to illuminate the issues and challenges. Now it's the time to act. Dr. Carolyn Lam: Thank you so much Kern for a beautiful paper. We are so proud to be publishing it in circulation. And thank you, Alana lovely, editor that we've said so many times. Thank you audience for joining us today. You've been listening to Circulation on the Run from Greg and I please tune in again. Next week, Dr. Greg Hundley: This program is copyright of the American heart association, 2021. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American heart association for more visit ahajournals.org.

Dr. Jennings is Associatet Professor of Systematic Theology and Africana Studies at Yale University and has written several books including The Christian Imagination: Theology and the Origins of Race (Yale 2010), which won the American Academy of Religion Award of Excellence in the Study of Religion in the Constructive-Reflective category the year after it appeared and, in 2015 and the Grawemeyer Award in Religion, the largest prize for a theological work in North America. His commentary on the Book of Acts, titled Acts: A Commentary, The Revolution of the Intimate (for the Belief Series, Westminster/John Knox) received the Reference Book of the Year Award from The Academy of Parish Clergy in 2018.In this episode, Dr. Jenning helps us understand how the book of Acts critiques empire and imperial values, and also how the early Christians in the book of Acts were wrestling with ethnic reconciliation and inclusion. Toward the end of the episode, we talk about the concept of “Whiteness”--what it means, what it doesn't mean, and how it can be a useful tool for people to use to think through the history and politics of race. Theology in the Raw Conference - Exiles in Babylon At the Theology in the Raw conference, we will be challenged to think like exiles about race, sexuality, gender, critical race theory, hell, transgender identities, climate change, creation care, American politics, and what it means to love your democratic or republican neighbor as yourself. Different views will be presented. No question is off limits. No political party will be praised. Everyone will be challenged to think. And Jesus will be upheld as supreme.Faith, Sexuality, and Gender Conference - Live in Boise or Stream OnlineIn the all-day conference, Dr. Preston Sprinkle dives deep into the theological, relational, and ministry-related questions that come up in the LGBTQ conversation.Support PrestonSupport Preston by going to patreon.comVenmo: @Preston-Sprinkle-1Connect with PrestonTwitter | @PrestonSprinkleInstagram | @preston.sprinkleYoutube | Preston SprinkleCheck out Dr. Sprinkle's website prestonsprinkle.comStay Up to Date with the PodcastTwitter | @RawTheologyInstagram | @TheologyintheRawIf you enjoy the podcast, be sure to leave a review.

At the beginning of the COVID-19 pandemic, thousands of psychotherapists were forced to migrate their practice to teletherapy or secure video.  While many have embraced this new mode of practice and have even found enhancements to their delivery of therapy, others are eager to return to the office or adopt a hybrid model.  Dr. Hannah Zeavin, author of the The Distance Cure: A History Teletherapy, joins us for a conversation around the history of teletherapy as well as systems-level implications for the wide adoption of teletherapy. In this conversation we cover:     the biggest misconceptions that psychotherapists are likely to labouring under with respect to the history and deployment of teletherapya discussion of the reality of every therapeutic exchange - whether virtual, in the office or otherwise - being mediated in some respect and existing within a "frame"the evidence-base around teletherapy3rd party payers stance towards teletherapy and whether a distinction between in-office therapy and teletherapy remains relevantthe dysfunctional focus on "activities" vs "outcomes" in an insurance-driven mental health system and how teletherapy could unwittingly accentuate this dynamicconsideration of therapy-process related factors in the context of teletherapy (e.g., client seeing the clinician within their home environment & vice versa)implications of the the appification/commodification of mental health services via digital platformsthe dangers of "batch processing" and "gamification" in the provision of therapy within a commodified mental health systemthe potential for the digital distribution of services to create “winner takes all” outcomes and the danger of a cost leader further commodifying mental health via call-center models or similarPotential unintended consequences of national licensure around the commodification of mental health services Dr. Zeavin's thoughts on the questions clinicians and practices should be grappling with right now in the context of tele therapyHannah Zeavin is a Lecturer in the Departments of English and History at the University of California, Berkeley and is on the Executive Committee of the University of California at Berkeley Center for Science, Technology, Medicine, and Society and on the Executive Committee of the Berkeley Center for New Media. Additionally, she is a visiting fellow at the Columbia University Center for the Study of Social Difference. Dr. Zeavin's first book, The Distance Cure: A History of Teletherapy is now out from MIT Press, with a Foreword by John Durham Peters. She is at work on her second book, Mother's Little Helpers: Technology in the American Family (MIT Press, 2023).  Dr. Zeavin serves as an Editorial Associate for The Journal of the American Psychoanalytic Association and is a co-founder of The STS Futures Initiative. Other work has appeared in or is forthcoming from American Imago, differences: A Journal of Feminist Cultural Studies, The Guardian, The Los Angeles Review of Books, Real Life Magazine, Slate, The Washington Post, Logic Magazine, and beyond. Dr. Zeavin received her B.A. from Yale University in 2012 and her Ph.D. from the Department of Media, Culture, and Communication at NYU in 2018.https://www.zeavin.org/

Over-worked or over-entertained? Our humanity gives us the joint gifts of both activity and passivity. We act and we are acted upon. But how do we balance and mediate these states? How do we cultivate long practices and habits that help us to inhabit the space between activity and passivity, bringing them together in a beautiful agency?Poet and linguist Alysia Harris joins Matt Croasmun for a discussion of that space between active and passive in human life—bringing the concepts of wonder, awareness/attention, patient receptivity to the natural world and to God, bearing witness to the autonomy and action of the other, and how she cultivates and meditates on these things in her own life.Show NotesNorman Wirzba, This Sacred Life: Humanity's Place in a Wounded WorldActive life vs passive lifeIntermediate category between activity and passivity: attentive awarenessActive receptivity and bearing witnessHuman beings enacting and reactingWitness as perception and responseCarl Sagan, Robin Kimmerer, Timothy WilburnWonder as a mediating emotion between active and passive"I'm not the entire system."Granting autonomy to a natural systemMaking the right impact through granting the sovereignty of the otherAdam and Eve as gardeners—beauty vs productivityGenesis: "Avad and Shamar"—Till and Keep, Serve and ProtectRestrain, observe, attend, and magnify"Me and God"Capitalism, scarcity mentality, and "enough"Ping-ponging between over-worked and over-entertainment—deficient visions of activity and deficient visions of passivityMark 4: Parable of the Sower. Scattering SeedsDynamic reciprocity and intentional permeabilityThe patience an orchid demands"Ideas have no use unless they have something to do with our lives."Practices and rituals to inhabit the space between active and passiveWriting habits—"faithful stewardship with less brings faithful stewardship with more"Dance as an embodied balance with intellectual workIntercessory prayer and producing opportunitiesWorking out of hope instead of strivingRunning, walking, granting the natural world autonomyAbout Alysia HarrisFollow Alysia Harris @PoppyinthewheatAlysia Nicole Harris was born in Fremont, California but grew up in Alexandria, VA and considers herself on all accounts a member of the ranks of great Southern women. At age 10 she wrote her first poem, after hearing about sonnets in English class. That class began her life-long love of poetry and the literary arts.Alysia went to The University of Pennsylvania where she experienced her first success as a writer and a performer. In 2008 she featured on the HBO documentary: Brave New Voices where she wowed audiences with her piece "That Girl". In 2010 Alysia graduated UPENN Summa Cum Laude with honors and was also inducted into the Phi Beta Kappa honor society. Alysia received her MFA in poetry from NYU in 2014 and her PhD in linguistics from Yale University in 2019. Her dissertation “The Non-Aspectual Meaning of African-American English ‘Aspect' Markers” breaks with traditional analyses and explores the discourse-oriented uses of the preverbal particles ‘be' and ‘done' in varieties of African-American English.Although she has experienced scholastic success, poetry has always come first in her heart. Cave Canem fellow, winner of the 2014 and 2015 Stephen Dunn Poetry Prizes, Pushcart Nominee, her poetry has appeared  in Best American Poets, Indiana Review, The Offing, Callaloo, Solstice Literary Magazine, Squaw Valley Review, Letters Journal, and Vinyl Magazine among others. Her first chapbook How Much We Must Have Looked Like Stars to Stars won the 2015 New Women's Voices Chapbook Contest and is available for purchase on site.Alysia was also a founding member of the internationally known performance poetry collective, The Strivers Row and has garnered over 5 million views on YouTUBE. She has toured nationally for the last 10 years and also performed at the United Nations and the US Embassies in Jordan and Ukraine, as well as in Australia, Canada, Germany, Slovakia, South Africa, the UAE, and the UK.Alysia now lives in Atlanta, GA where she works as a consultant for the Morehouse Center for Excellence in Education and as arts and soul editor at Scalawag Magazine, a nonprofit POC-led, women run media organization focused on Southern movement, community, and dissent. She is working on a book of poems and a collection of essays about the intersections of faith, violence, and the natural world. Production NotesThis podcast featured poet Alysia Harris and biblical scholar Matt CroasmunEdited and Produced by Evan RosaHosted by Evan RosaProduction Assistance by Martin Chan & Nathan JowersA Production of the Yale Center for Faith & Culture at Yale Divinity School https://faith.yale.edu/aboutSupport For the Life of the World podcast by giving to the Yale Center for Faith & Culture: https://faith.yale.edu/give

Welcome to this Saturday Special Edition Part 3 of 3 in which Cynthia Chaplin interviews Sarah Heller MW. In this episode she discusses the approach to tasting Italian wine devised by the Vinitaly International Academy. Sarah talks about the reformatted, tasting-intensive VIA Italian Wine Ambassador course and the new VIA Tasting Schematic, VIA's standardized tasting grid with descriptors which are specific to Italian wines. The new VIA schematic forms the basis of both tasting sessions during the course and the blind tasting section of the exam. In the interview, Sarah goes through each descriptor and explains its relevance to Italian wines. If you are planning to take the next VIA Italian Wine Ambassador course, you cannot miss this podcast! Before telling you more about our great episode we want to give a shout out to our new Sponsor Vivino! the world's largest online wine marketplace - The Vivino app makes it easy to choose wine. Enjoy expert team support, door to door delivery and honest wine reviews to help you choose the perfect wine for every occasion. Vivino - Download the app on Apple or Android and discover an easier way to choose wine! Find out more about by visiting: www.vivino.com/IT/en/ or download the app: www.vivino.com/app More about Sarah Heller MW: Wine educator and wine branding expert, content creator and proprietor of Radix + Folium Design. Recently appointed to the faculty of the Vinitaly International Academy, Sarah Heller is a content creator, visual artist and wine branding expert based in Hong Kong and at 30 is the world's youngest Master of Wine. Having graduated from Yale University with a degree in fine art, Sarah began her career in the New York and Hong Kong wine trades and wineries in France and Italy. She was Executive Director of events and education firm Meiburg Wine Media in Hong Kong for three years. As well as being a Master of Wine and an Associate of the Institute of Wine and Spirits, Sarah is a Society of Wine Educators Certified Specialist of Wine and Spirits. She is the proprietor of Radix + Folium Design. If you want to learn more about Sarah & today's topic, you can by visiting: sarahheller.com/ vinitalyinternational.com/wordpress/vi…nal-academy/ More about the host Cynthia Chaplin: Passionate US/UK wine professional, focus on the Italian wine sector with particular interest in sparkling and rosé wines. Experienced educator and presenter, talented communicator and writer. Qualified sommelier and wine judge. Translator and editor for wine reviews and websites. Actively seeking roles that allow me to share knowledge and experience with a global audience, as well as continue my personal growth and development in the wine industry. Cynthia has recently taken over the show “Voices” on the Italian Wine Podcast as well! To find out more about Cynthia Chaplin visit: blablawine.com/en/author/cynthia…chaplingmail-com/ Instagram: @kiss_my_glassx LinkedIn: www.linkedin.com/in/cynthia-chaplin-190647179/ Let's keep in touch! Follow us on our social media channels: Instagram @italianwinepodcast Facebook @ItalianWinePodcast Twitter @itawinepodast Tiktok @MammaJumboShrimp LinkedIn @ItalianWinePodcast If you feel like helping us, donate here www.italianwinepodcast.com/donate-to-show/ We also want to give a shout out to our sponsor Ferrowine. The largest alcoholic beverage shop in Italy since 1920! They have generously provided us with our brand new Italian Wine Podcast T-shirts, and we love them! Check out Ferrowine's site, they have great wines, food pairings and so much more! www.ferrowine.it/

In his new book "Humane: How the United States Abandoned Peace and Reinvented War," scholar Samuel Moyn argues that post-9/11 efforts to reform the conduct of US military operations have ultimately sanitized and prolonged the underlying illegal warfare. Moyn discusses the Obama administration's key role in sanitizing warfare and how it undermined the US anti-war movement. He also addresses criticism of how the legendary human rights attorney Michael Ratner factors into his book's arguments. Guest: Samuel Moyn. Professor at Yale Law School and a professor of history at Yale University. His new book is "Humane: How the United States Abandoned Peace and Reinvented War." Support Pushback at Patreon: https://www.patreon.com/aaronmate

➡️ Like The Show? Leave A Rating: https://ratethispodcast.com/successstory ➡️ About The Guest Miko is a General Partner with Gumi Ventures, a US $30M investment fund focused early stage blockchain startups and a cofounder of crypto exchange Evercoin, Miko fell in love with open source software 25 years ago as chief Evangelist for the Java Language and Platform at Sun Microsystems.  Since then he has been building open source software startups in Silicon Valley including raising over $50 million in venture capital for developer platform companies such as Gradle and financial infrastructure companies like Hazelcast and has participated in multiple exits including INFRAVIO, webMethods, and Db4O.  He is an advisor in successful startups like Celsius (CeFi Lending), Idle Finance (DeFi Yield Aggregator), Pundi X (Payments), and KEYLESS (ID infrastructure). He has been an investor with Focus Ventures, a firm with over $800M under management, 9 IPOs and 44 exits and blockchain firm Pantera Capital. He holds a Master's degree in Neuroscience from Yale University where he worked on abstract computational neural networks. ➡️ Talking Points 00:00 - Intro. 08:02 - Blockchain.. breaking away from institutional systems. 15:42 - Crypto hacking. 20:21 - Questioning people's motives. 26:09 - What is De-Fi? 32:10 - Blockchain & Crypto adoption. 46:11 - How De-Fi is changing lives. ➡️ Show Links https://twitter.com/mikojava https://miko.com/ ➡️ Podcast Sponsors 1. Canva — Create Content & Design Anything (No Skill Required) https://canva.me/successstory — Free 45 Day Canva Pro Trial 2. Better Help —Virtual Therapy & Mental Wellness  https://betterhelp.com/scottclary — 10% Off First Month 3. Postie—Direct mail for digital marketers. https://postie.com/successstory (Free Demo)

Ayaan speaks with Lawrence Krauss about the new religion of wokeism and how it spread throughout academia. They discuss the impacts that political correctness and cancel culture have on science, and what it means for the future. Lawrence Krauss is an internationally known theoretical physicist. He is President of The Origins Project Foundation and host of The Origins Podcast with Lawrence Krauss. He has written over 500 publications, including for The New York Times, Wall Street Journal, Quillette, The New Yorker, Prospect Magazine, and The Economist. Lawrence has written numerous popular books including NYT bestsellers: The Physics of Star Trek; and A Universe from Nothing. His newest book is The Physics of Climate Change. He received his PhD from MIT and then moved to the Harvard Society of Fellows. Following eight years as a professor at Yale University, he was appointed as a full professor with an endowed chair while still in his thirties. During his career, he has held endowed professorships and distinguished research appointments at numerous institutions. Between 2006 and 2018, he was Chair of the Board of Sponsors of the Bulletin of the Atomic Scientists. Follow him on Twitter @lkrauss1. Follow Ayaan on Twitter @ayaan.

Buckle up, y'all because this episode is jam-packed with nuggets of wisdom that will stick with you long after listening. Today I kicked it in the booth with bestselling author, socially conscious entrepreneur, and speaker Laura Gassner Otting (aka LGO). We talked about finding what you love to do, defining success and what is enough for yourself, motivation vs. discipline, control, imposter syndrome, and a new way to think about confidence. LGO is incredibly entertaining, an excellent storyteller, and someone who offers a fresh perspective. This episode has a little bit of everything for everyone and is well worth your time. Not to mention, it starts out with some PRO tips for ordering at the diner. Check it out!   About the Guest:  Washington Post Best Selling Author and Motivational Keynote speaker, Laura Gassner Otting, inspires people to push past the doubt and indecision that keep great ideas in limbo because her presentations make listeners think bigger and accept greater challenges that reach beyond their limited scope of belief. She delivers strategic thinking, well-honed wisdom, and perspective generated by decades of navigating change across the start-up, nonprofit, political, as well as philanthropic landscapes. Laura dares listeners to find their voice, and generate the confidence needed to tackle larger-than-life challenges. She leads them to seek new ways of leading, managing and mentoring others. Laura's entrepreneurial edge has been well-honed over a 25-year career that started as a Presidential Appointee in Bill Clinton's White House, where she helped shape AmeriCorps. She left a leadership role at the respected nonprofit search firm, Isaacson, Miller, to expand the startup ExecSearches.com. Laura also founded and ran the Nonprofit Professionals Advisory Group, which partnered with the full gamut of mission-driven nonprofit executives, from start-up dreamers to scaling social entrepreneurs to global philanthropists. In 2015, Laura sold NPAG to the team that helped her build it, both because she was hungry for the next chapter and because she held an audacious dream of electing our nation's first female president. Along the way, while serving on Hillary Clinton's National Finance Committee, she was asked to do a TEDx talk which became so popular that it launched a speaking career. Laura has spoken across the United States and internationally to universities, companies, conferences, accelerators, TEDx, and the US Military. She is the author of Mission-Driven: Moving from Profit to Purpose (2015) and the Washington Post Best Seller Limitless: How to Ignore Everybody, Carve Your Own Path, and Live Your Best Life (2019). She lives with her husband, two teenage sons, and troublesome puppy outside of Boston, MA. Fun facts: I went to computer sleep away camp. I am running my fourth marathon in a week, having never run a mile in my life before I turned 39, and now the reigning lightweight indoor rowing champion of my age group. I have an irrational fear of whales.    Connect with Laura and learn more: myfourquestions.com lauragassnerotting.com @heylgo on Instagram About the Host:  Friends! Here's a somewhat stuffy bio of me:   I am an author, professional speaker, coach, host, and entrepreneur. My first book, Leading Imperfectly: The value of being authentic for leaders, professionals, and human beings, is available wherever people buy books. I speak internationally to willing and unwilling attendees about authenticity, vulnerability, and leadership. My clients include American Express, General Electric (GE), Accenture, Yale University, The Ohio State University, and many others. As a speaker, I am doing the two things I loves the most: making people think and making people laugh!  I host my own events multiple times a year. They are 2-day events called Living Imperfectly Live (and sometimes they are 1-day virtual events). They...

In this special Bonus episode, Chris has an extended dialogue with General Stan McChrystal, US Army (Retired) about his new book: Risk: A User's Guide,  co-authored with Anna Butrico. They talk through assessing risk in our own lives: amid the pandemic and persistent uncertainty at work and at home, with real world examples of how to systematically detect and respond to it.  This is a conversation not to miss.  General Stanley McChrystal retired in July 2010 as a four-star general in the U.S. Army. His last assignment was as the commander of the International Security Assistance Force and as the commander of the U.S. forces in Afghanistan. He had previously served as the director of the Joint Staff and as the commander of the Joint Special Operations Command. The author of My Share of the Task, Team of Teams, and Leaders, he is currently a senior fellow at Yale University's Jackson Institute for Global Affairs and the cofounder of the McChrystal Group.

Thank you for joining us on Breakfast With Champions! Today we listen in to Glenn Lundy interviewing Marc Brackett! Brackett is the Founder of the Yale Center for Emotional Intelligence, Professor in the Child Study Center of Yale University. Lead developer of RULER, an evidence-based approach to social and emotional learning!

This episode is supported by Brizo • Monograph • Miele • Graphisoft Peter L. Gluck is founder and principal of GLUCK+ in New York. Named by Fast Company as a top 10 most innovative companies in architecture, the firm is recognized for Architect Led Design Build. The practice is dedicated to pushing the boundaries of design with real-world expertise to craft bold and conceptually unique architecture. The firm's approach has been featured in Architectural Record "The New Master Builders," The Architects Newspaper "Inside Architecture's One-Stop Shop, and Architect "Best Practices: Engaging in Architect Led Design Build." The diverse portfolio of work is consistently recognized through national and international design awards and publications. Notable award-winning projects include California House, an updated take on the Arts & Architecture Case Study Houses; Bridge, the first LEED Gold high-rise development in Philadelphia; Pilkey Laboratory, a LEED Gold science research facility for Duke University; The Stack, the first prefabricated steel and concrete modular residential development in New York City; and Cary Leeds Center for Tennis & Learning, hailed by The New York Times as “one of the city's best new works of public architecture.” A frequently invited guest lecturer and keynote speaker on the work of GLUCK+, Peter Gluck also has spoken widely on the responsibility of architects to change the profession. Peter received both a Bachelor of Arts and a Master of Architecture from Yale University. He and others in his class were the catalyst for what would become the Yale Building Project. He has taught at Columbia and Yale schools of architecture and curated exhibitions at the Museum of Modern Art in New York and the Milan Triennale. The Modern Impulse: Peter L. Gluck and Partners, the firm's monograph, was published in 2008.  SUBSCRIBE  • Apple Podcasts  • YouTube  • Spotify CONNECT  • Website: www.secondstudiopod.com • Instagram • Facebook • Twitter  • Call or text questions to 213-222-6950 SUPPORT Leave a review :) EPISODE CATEGORIES  •  Interviews: Interviews with industry leaders.  •  Design Companion: Informative talks for clients.   •  After Hours (AH): Casual conversations about everyday life.  •  Design Reviews: Reviews of creative projects and buildings.  •  Fellow Designer: Tips for designers.

In May of 2008, a 7.9 magnitude earthquake struck Sichuan, China in the middle of the afternoon. Entire towns were destroyed, schools collapsed, and over 80,000 people died — many of them schoolchildren. When grief-stricken families were denied information about exactly who and how many children died, Chinese artist Ai Weiwei initiated a critical and controversial response by compiling their names and expressing a region's collective grief through art. Enter Ian Boyden, who first encountered the thousands of names while curating Ai's 2016 exhibition, Ai Weiwei: Fault Line, at the San Juan Islands Museum of Art. Over the course of a year, Boyden read and translated the poetic essence of the children's names and composed heartbreaking, elegiac verses in response. The resulting work, A Forest of Names, meditates on humanity, memory, and language. In our 109th episode of In the Moment, Shin Yu Pai and Boyden explore his haunting and healing tribute of the thousands of lives lost. Ian Boyden is a visual artist, translator, writer, and curator whose work holds a deep awareness of East Asian aesthetics. He studied for several years in China and Japan and holds degrees in Art History from Wesleyan University and Yale University. His art and published work are found in many public collections including Reed College, Stanford University, the Portland Art Museum, and the Victoria & Albert Museum. His work is interdisciplinary, and past collaborations have involved scientists, poets, composers, and visual artists. Shin Yu Pai is Program Director for Town Hall. She is the author of eleven books of poetry. Her work has appeared in publications throughout the U.S., Japan, China, Taiwan, the United Kingdom, and Canada. Her essays and nonfiction writing have appeared in Tricycle, YES! Magazine, The Rumpus, City Arts, The Stranger, Medium, and others. Buy the Book: A Forest of Names: 108 Meditations  Presented by Town Hall Seattle. To become a member or make a donation click here. 

Continuing our #MethodsandMeasuring series, Chris and Cara chat with Dr. Claudia Valeggia about her inspirational origin story, her work on reproductive health in the Qom of Argentina, and the importance of biological meaningfulness in data analysis. Dr. Valeggia is a Professor of Anthropology at Yale University and a PI in the Yale Reproductive Ecology Lab. You can contact Dr. Valeggia at claudia.valeggia@yale.edu and on Twitter @ClaudiaValeggia Visit the Yale Reproductive Ecology Lab site at https://reproeco.yale.edu and on Twitter @YaleReproEco Contact the Sausage of Science Podcast and Human Biology Association: Facebook: www.facebook.com/groups/humanbiologyassociation Website:humbio.org/, Twitter: @HumBioAssoc Cara Ocobock, Website: sites.nd.edu/cara-ocobock/, Email:cocobock@nd.edu, Twitter:@CaraOcobock Chris Lynn, HBA Public Relations Committee Chair, Website: cdlynn.people.ua.edu/, Email: cdlynn@ua.edu, Twitter:@Chris_Ly Delaney Glass, Website: dglass.netlify.app/, Email: dglass1@uw.edu, Twitter: @GlassDelaney Alexandra Niclou, Email: aniclou@nd.edu, Twitter: @fiat_Luxandra

Parenting With Impact with Elaine Taylor-Klaus and Diane Dempster  Episode 015 Parenting Anxious Childhood Emotions with Eli Lebowitz Professor Eli Lebowitz studies and treats childhood and adolescent anxiety and is Director of the Program for Anxiety Disorders at the Yale Child Study Center. His research focuses on the development, neurobiology, and treatment of anxiety and related disorders, with special emphasis on cross-generational and familial influences in these disorders. Dr. Lebowitz is the lead investigator on multiple funded research projects, and is the author of numerous research papers and of books and chapters on childhood and adolescent anxiety.  Listen to this inspiring Parenting With Impact episode with Eli Lebowitz about the unique aspects of childhood anxiety and how it is managed. Here is what to expect on this week's show: How SPACE helps change behaviors to help your kid manage anxiety Parents are not the cause of anxiety, but are integral in healing it Childhood anxiety is inherently different from adult anxiety due to development Connect with Eli: Links Mentioned: For information about SPACE: www.spacetreatment.net For information about the Childhood Study Center at Yale University: https://medicine.yale.edu/childstudy/about/   Follow on Facebook @YaleChildStudyCenter @spacetreatments  Top 10 Ways to Stop Meltdowns in Their Tracks In this FREE insider's guide from the experts at ImpactParents, learn 10 tips that will actually help you reduce the frequency and intensity of meltdowns for good! Used by parents all over the world, successfully help children manage their intense emotions and triggers so they learn to respond with respect and calm. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to this Saturday Special Edition Part 2 of 3 in which Cynthia Chaplin interviewed in conversation with Sarah Heller MW. In this episode she discusses the approach to tasting Italian wine devised by the Vinitaly International Academy. Sarah talks about the reformatted, tasting-intensive VIA Italian Wine Ambassador course and the new VIA Tasting Schematic, VIA's standardized tasting grid with descriptors which are specific to Italian wines. The new VIA schematic forms the basis of both tasting sessions during the course and the blind tasting section of the exam. In the interview, Sarah goes through each descriptor and explains its relevance to Italian wines. If you are planning to take the next VIA Italian Wine Ambassador course, you cannot miss this podcast! Before telling you more about our great episode we want to give a shout out to our new Sponsor Vivino! the world's largest online wine marketplace - The Vivino app makes it easy to choose wine. Enjoy expert team support, door to door delivery and honest wine reviews to help you choose the perfect wine for every occasion. Vivino - Download the app on Apple or Android and discover an easier way to choose wine! Find out more about by visiting: www.vivino.com/IT/en/ or download the app: www.vivino.com/app More about Sarah Heller MW: Wine educator and wine branding expert, content creator and proprietor of Radix + Folium Design. Recently appointed to the faculty of the Vinitaly International Academy, Sarah Heller is a content creator, visual artist and wine branding expert based in Hong Kong and at 30 is the world's youngest Master of Wine. Having graduated from Yale University with a degree in fine art, Sarah began her career in the New York and Hong Kong wine trades and wineries in France and Italy. She was Executive Director of events and education firm Meiburg Wine Media in Hong Kong for three years. As well as being a Master of Wine and an Associate of the Institute of Wine and Spirits, Sarah is a Society of Wine Educators Certified Specialist of Wine and Spirits. She is the proprietor of Radix + Folium Design. If you want to learn more about Sarah & today's topic, you can by visiting: sarahheller.com/ vinitalyinternational.com/wordpress/vi…nal-academy/ More about the host Cynthia Chaplin: Passionate US/UK wine professional, focus on the Italian wine sector with particular interest in sparkling and rosé wines. Experienced educator and presenter, talented communicator and writer. Qualified sommelier and wine judge. Translator and editor for wine reviews and websites. Actively seeking roles that allow me to share knowledge and experience with a global audience, as well as continue my personal growth and development in the wine industry. Cynthia has recently taken over the show “Voices” on the Italian Wine Podcast as well! To find out more about Cynthia Chaplin visit: blablawine.com/en/author/cynthia…chaplingmail-com/ Instagram: @kiss_my_glassx LinkedIn: www.linkedin.com/in/cynthia-chaplin-190647179/ Let's keep in touch! Follow us on our social media channels: Instagram @italianwinepodcast Facebook @ItalianWinePodcast Twitter @itawinepodast Tiktok @MammaJumboShrimp LinkedIn @ItalianWinePodcast If you feel like helping us, donate here www.italianwinepodcast.com/donate-to-show/ We also want to give a shout out to our sponsor Ferrowine. The largest alcoholic beverage shop in Italy since 1920! They have generously provided us with our brand new Italian Wine Podcast T-shirts, and we love them! Check out Ferrowine's site, they have great wines, food pairings and so much more! www.ferrowine.it/

Race, while drawn from the visual cues of human diversity, is an idea with a measurable past, an identifiable present, and an uncertain future. The concept of race has been at the center of both triumphs and tragedies in American history and has had a profound effect on the human experience. Race Unmasked: Biology and Race in the Twentieth Century (Columbia UP, 2018)revisits the origins of commonly held beliefs about the scientific nature of racial differences, examines the roots of the modern idea of race, and explains why race continues to generate controversy as a tool of classification even in our genomic age. Surveying the work of some of the twentieth century's most notable scientists, Race Unmasked reveals how genetics and related biological disciplines formed and preserved ideas of race and, at times, racism. A gripping history of science and scientists, Race Unmasked elucidates the limitations of a racial worldview and throws the contours of our current and evolving understanding of human diversity into sharp relief. About the author: Michael Yudell is a public health ethicist, award-winning historian, and professor and Vice Dean at the College of Health Solutions at Arizona State University. He is the co-editor of the Columbia University Press Series Race, Inequality, and Health and the author of several books, including Race Unmasked, for which he won the Arthur J. Viseltear Award from the American Public Health Association. About the interviewer: Hussein Mohsen is a PhD/MA Candidate in Computational Biology and Bioinformatics/History of Science and Medicine at Yale University. His research interests include machine learning, cancer genomics, and the history of human genetics. For more about his work, visit http://www.husseinmohsen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

I recently had the true pleasure of chatting with my former teacher: violinist and pedagogue extraordinaire Brian Lewis!  He is an exceptionally dedicated and passionate performer who is committed to growing the legacies of his own two incredible teachers, the great Dorothy DeLay and Dr. Shinichi Suzuki. In our conversation we touched on... How Brian's artistic path has unfolded, from his own childhood studies to today's pedagogical pursuits (3:13) Teaching the language of music (11:50) Practicing concentration, and the importance of shifting your focus to refocusing for optimizing your practice (13:00) The legacy of Dorothy DeLay: how she empowered her students (including Brian) through positivity, removing judgement from her instruction, encouraging questions, and presenting the possibilities of playing to help young musicians sort out their own paths (15:01) Leading teaching with love, and the lasting, negative impacts of “abusive teaching” (25:13) Practicing habits (formed by DeLay and Suzuki) that helped set his playing apart, focusing on simplicity, the importance of listening, and repeating your own study of a score (30:01) Brian's advice for collegiate musicians to use your time in conservatory to prepare for a life as a professional musician (35:09) The lineage of musicianship and importance of flexibility (42:15) Brian's answers to a series of rapid-fire questions, including consistent practicing, his most memorable performances, favorite practice room tools, and book recommendation! (44:10)   MORE ON BRIAN LEWIS: One of the most versatile violinists on the current scene, Brian Lewis is an exceptionally gifted and charismatic artist. "There are a lot of fine violinists on the concert stage today, but few can match Lewis for an honest virtuosity that supremely serves the music,” reports the Topeka Capital-Journal. Much sought after as a performer and teacher, Mr. Lewis concertizes and teaches around the globe, and is dedicated to growing the legacy of Shin'ichi Suzuki and Dorothy DeLay. Acclaimed performances include concerto debuts in both New York's Carnegie Hall and Avery Fisher Hall, as well as performances with the Orchestra of St. Luke's, the Berlin (Germany), Louisiana, Kansas City, Hartford, Syracuse, Odense (Denmark), Lima (Peru), Boulder, Guadalajara (Mexico), Sinfonia Toronto (Canada), ROCO and American Symphony orchestras, among many others.   He has released six CDs, including as soloist with the London Symphony Orchestra of music by Leonard Bernstein and Hollywood composer Michael McLean for the Delos Label. Mr. Lewis began his violin studies at the age of four, participating in the Ottawa Suzuki Strings program, and traveling to Japan twice to study with Dr. Suzuki. He received his Bachelor and Master degrees from The Juilliard School, studying with the renowned pedagogue, Dorothy DeLay. Mr. Lewis holds the David and Mary Winton Green Chair in String Performance and Pedagogy at The University of Texas at Austin. In addition, he is Artistic Director of the Starling-DeLay Symposium on Violin Studies at The Juilliard School in New York City, Artistic Director and Faculty and the Brian Lewis Young Artists Program held most recently in Fairbanks, AK. He has also recently held positions as the Class of '57 Visiting Professor of Music at Yale University and Visiting Professor at the Cleveland Institute of Music. More information about Mr. Lewis can be found at www.brianlewisviolin.com.   PRACTICING FOR PEAK PERFORMANCE: I'm excited to tell you that Practicing for Peak Performance is now available for download! Go to MindOverFinger.com for access to all the tools that will help you transform your practice, gain confidence in your process, and start performing at your best.  With the purchase of PPP, you gain: Access to all recorded content - over 7 hours of instruction Guidance in effective high-performance systems Detailed handouts For a limited time only, a free 30-minute consultation with me. PPP alumnus Karmen Palusoo has this to say about PPP: “For a long time I have had this belief that learning an instrument is difficult and hard work or that it has to be, and there is no other way. Only a few weeks after PPP, I am starting to feel that change! My everyday practice sessions are now filled with freedom and ease!”   THANK YOU: A HUGE thank you to my fantastic producer, Bella Kelly, who works really hard to make this podcast as pleasant to listen to as possible for you. Most sincere thank you to composer Jim Stephenson who graciously provided the show's musical theme.  Concerto #1 for Trumpet and Chamber Orchestra – Movement 2: Allegro con Brio, performed by Jeffrey Work, trumpet, and the Lake Forest Symphony, conducted by Jim Stephenson. Thank you to pianist-singer-song-writer Louise Kelly for the introduction!  You can find out more about Kelly and her creative work by visiting louisekelly.com.    MIND OVER FINGER: I encourage you to visit MindOverFinger.com for a plethora of resources on mindful practice and information on how to work with me. Sign up for my newsletter and receive your free guide to a highly productive mindful practice using a metronome! mindoverfinger.com https://www.facebook.com/mindoverfinger/ https://www.instagram.com/mindoverfinger/

Natural compound in basil may protect against Alzheimer's disease pathology University of South Florida, October 5, 2021 Fenchol, a natural compound abundant in some plants including basil, can help protect the brain against Alzheimer's disease pathology, a preclinical study led by University of South Florida Health (USF Health) researchers suggests. The new study published Oct. 5 in the Frontiers in Aging Neuroscience, discovered a sensing mechanism associated with the gut microbiome that explains how fenchol reduces neurotoxicity in the Alzheimer's brain. Emerging evidence indicates that short-chain fatty acids (SCFAs)– metabolites produced by beneficial gut bacteria and the primary source of nutrition for cells in your colon—contribute to brain health. The abundance of SCFAs is often reduced in older patients with mild cognitive impairment and Alzheimer's disease, the most common form of dementia. However, how this decline in SCFAs contributes to Alzheimer's disease progression remains largely unknown. Gut-derived SCFAs that travel through the blood to the brain can bind to and activate free fatty acid receptor 2 (FFAR2), a cell signaling molecule expressed on brain cellscalled neurons. "Our study is the first to discover that stimulation of the FFAR2 sensing mechanism by these microbial metabolites (SCFAs) can be beneficial in protecting brain cells against toxic accumulation of the amyloid-beta (Aβ) protein associated with Alzheimer's disease," said principal investigator Hariom Yadav, Ph.D., professor of neurosurgery and brain repair at the USF Health Morsani College of Medicine, where he directs the USF Center for Microbiome Research. One of the two hallmark pathologies of Alzheimer's disease is hardened deposits of Aβ that clump together between nerve cells to form amyloid protein plaques in the brain. The other is neurofibrillary tangles of tau protein inside brain cells. These pathologies contribute to the neuron loss and death that ultimately cause the onset of Alzheimer's, a neurodegenerative disease characterized by loss of memory, thinking skills and other cognitive abilities. Dr. Yadav and his collaborators delve into molecular mechanisms to explain how interactions between the gut microbiome and the brain might influence brain health and age-related cognitive decline. In this study, Dr. Yadav said, the research team set out to uncover the "previously unknown" function of FFAR2 in the brain. The researchers first showed that inhibiting the FFAR2 receptor (thus blocking its ability to "sense" SCFAs in the environment outside the neuronal cell and transmit signaling inside the cell) contributes to the abnormal buildup of the Aβ protein causing neurotoxicity linked to Alzheimer's disease. Then, they performed large-scale virtual screening of more than 144,000 natural compounds to find potential candidates that could mimic the same beneficial effect of microbiota produced SCFAs in activating FFAR2 signaling. Identifying a natural compound alternative to SCFAs to optimally target the FFAR2 receptor on neurons is important, because cells in the gut and other organs consume most of these microbial metabolites before they reach the brain through blood circulation, Dr. Yadav noted. Dr. Yadav's team narrowed 15 leading compound candidates to the most potent one. Fenchol, a plant-derived compound that gives basil its aromatic scent, was best at binding to the FFAR's active site to stimulate its signaling. Further experiments in human neuronal cell cultures, as well as Caenorhabditis (C.) elegans (worm) and mouse models of Alzheimer's disease demonstrated that fenchol significantly reduced excess Aβ accumulation and death of neurons by stimulating FFAR2 signaling, the microbiome sensing mechanism. When the researchers more closely examined how fenchol modulates Aβ-induced neurotoxicity, they found that the compound decreased senescent neuronal cells, also known as "zombie" cells, commonly found in brains with Alzheimer's disease pathology. Zombie cells stop replicating and die a slow death. Meanwhile, Dr. Yadav said, they build up in diseased and aging organs, create a damaging inflammatory environment, and send stress or death signals to neighboring healthy cells, which eventually also change into harmful zombie cells or die. "Fenchol actually affects the two related mechanisms of senescence and proteolysis," Dr. Yadav said of the intriguing preclinical study finding. "It reduces the formation of half-dead zombie neuronal cells and also increases the degradation of (nonfunctioning) Aβ, so that amyloid protein is cleared from the brain much faster." Before you start throwing lots of extra basil in your spaghetti sauce or anything else you eat to help stave off dementia, more research is needed—including in humans. In exploring fenchol as a possible approach for treating or preventing Alzheimer's pathology, the USF Health team will seek answers to several questions. A key one is whether fenchol consumed in basil itself would be more or less bioactive (effective) than isolating and administering the compound in a pill, Dr. Yadav said. "We also want to know whether a potent dose of either basil or fenchol would be a quicker way to get the compound into the brain."   Researchers find sense of purpose associated with better memory Florida State University, October 6, 2021 Add an improved memory to the list of the many benefits that accompany having a sense of purpose in life. A new study led by Florida State University researchers showed a link between an individual's sense of purpose and their ability to recall vivid details. The researchers found that while both a sense of purpose and cognitive function made memories easier to recall, only a sense of purpose bestowed the benefits of vividness and coherence. The study, which focused on memories related to the COVID-19 pandemic, was published in the journal Memory. "Personal memories serve really important functions in everyday life," said Angelina Sutin, a professor in the College of Medicine and the paper's lead author. "They help us to set goals, control emotions and build intimacy with others. We also know people with a greater sense of purpose perform better on objective memory tests, like remembering a list of words. We were interested in whether purpose was also associated with the quality of memories of important personal experiences because such qualities may be one reason why purpose is associated with better mental and physical health." Nearly 800 study participants reported on their sense of purpose and completed tasks that measured their cognitive processing speed in January and February 2020, before the ongoing coronavirus pandemic took hold in the U.S. Researchers then measured participants' ability to retrieve and describe personal memories about the pandemic in July 2020, several months into the public health crisis. Participants with a stronger sense of purpose in life reported that their memories were more accessible, coherent and vivid than participants with less purpose. Those with a higher sense of purpose also reported many sensory details, spoke about their memories more from a first-person perspective and reported more positive feeling and less negative feeling when asked to retrieve a memory. The researchers also found that depressive symptoms had little effect on the ability to recall vivid details in memories, suggesting that the connection between life purpose and memory recall is not due to the fewer depressive symptoms among individuals higher in purpose. Purpose in life has been consistently associated with better episodic memory, such as the number of words retrieved correctly on a memory task. This latest research expands on those connections to memory by showing a correlation between purpose and the richness of personal memory. "We chose to measure the ability to recall memories associated with the COVID-19 pandemic because the pandemic is an event that touched everyone, but there has been a wide range of experiences and reactions to it that should be apparent in memories," said co-author Martina Luchetti, an assistant professor in the College of Medicine. Along with the association with better memory, previous research has found other numerous benefits connected with having a sense of purpose, from a lower risk of death to better physical and mental health. "Memories help people to sustain their well-being, social connections and cognitive health," said co-author Antonio Terracciano, a professor in the College of Medicine. "This research gives us more insight into the connections between a sense of purpose and the richness of personal memories. The vividness of those memories and how they fit into a coherent narrative may be one pathway through which purpose leads to these better outcomes.   Vitamin D protects against severe asthma attacks Queen Mary University of London, October 3, 2021 Taking oral vitamin D supplements in addition to standard asthma medication could halve the risk of asthma attacks requiring hospital attendance, according to research led by Queen Mary University of London (QMUL). Asthma affects more than 300 million people worldwide and is estimated to cause almost 400,000 deaths annually. Asthma deaths arise primarily during episodes of acute worsening of symptoms, known as attacks or 'exacerbations', which are commonly triggered by viral upper respiratory infections. Vitamin D is thought to protect against such attacks by boosting immune responses to respiratory viruses and dampening down harmful airway inflammation. The new study, funded by the National Institute for Health Research, and published in The Lancet Respiratory Medicine, collated and analysed the individual data from 955 participants in seven randomised controlled trials, which tested the use of vitamin D supplements. Overall, the researchers found that vitamin D supplementation resulted in: a 30 per cent reduction in the rate of asthma attacks requiring treatment with steroid tablets or injections - from 0.43 events per person per year to 0.30. a 50 per cent reduction in the risk of experiencing at least one asthma attack requiring Accident and Emergency Department attendance and/or hospitalisation - from 6 per cent of people experiencing such an event to 3 per cent. Vitamin D supplementation was found to be safe at the doses administered. No instances of excessively high calcium levels or renal stones were seen, and serious adverse events were evenly distributed between participants taking vitamin D and those on placebo. Lead researcher Professor Adrian Martineau said: "These results add to the ever growing body of evidence that vitamin D can support immune function as well as bone health. On average, three people in the UK die from asthma attacks every day. Vitamin D is safe to take and relatively inexpensive so supplementation represents a potentially cost-effective strategy to reduce this problem." The team's use of individual participant data also allowed them to query the extent to which different groups respond to vitamin D supplementation, in more detail than previous studies. In particular, vitamin D supplementation was found to have a strong and statistically-significant protective effect in participants who had low vitamin D levels to start with. These participants saw a 55 per cent reduction in the rate of asthma exacerbations requiring treatment with steroid tablets or injections - from 0.42 events per person per year to 0.19. However, due to relatively small numbers of patients within sub-groups, the researchers caution that they did not find definitive evidence to show that effects of vitamin D supplementation differ according to baseline vitamin D status. Professor Hywel Williams, Director of the NIHR Health Technology Assessment Programme, said: "The results of this NIHR-funded study brings together evidence from several other studies from over the world and is an important contribution to reducing uncertainties on whether Vitamin D is helpful for asthma - a common condition that impacts on many thousands of people worldwide." Dr David Jolliffe from QMUL, first author on the paper, added: "Our results are largely based on data from adults with mild to moderate asthma: children and adults with severe asthma were relatively under-represented in the dataset, so our findings cannot necessarily be generalised to these patient groups at this stage. Further clinical trials are on-going internationally, and we hope to include data from them in a future analysis to determine whether the promise of today's results is confirmed in an even larger and more diverse group of patients."     Study Shows Lifestyle Choices Have Significant Impact on Multiple Chronic Conditions, Significant Implications For Reducing Costs Yale University,  October 05, 2021 In a study published in the Journal of Preventive Medicine, Adams and colleagues showed a linear association between a number of modifiable risk factors and multiple chronic conditions, making those modifications a key to health care cost savings and to preventing a wide range of conditions. The data analyzed for the study, https://authors.elsevier.com/a/1VpFeKt2pmc9H, were from the publicly available 2013 Behavioral Risk Factor Surveillance System and included 483,865 non-institutionalized US adults ages 18 years old or older. Chronic conditions included asthma, arthritis, heart disease, stroke, chronic obstructive pulmonary disease (COPD), cognitive impairment, cancer other than skin, and kidney disease. Risk factors included obesity, current smoking, sedentary lifestyle, inadequate fruit and vegetable consumption and sleeping other than seven to eight hours, while depression, hypertension, high cholesterol, and diabetes were considered in each category. Previous research by Thorpe and colleagues had estimated that the care of adults with four or more chronic conditions (17.1% of all adults in the study) is responsible for 77.6% of all health care costs in the U.S. today. The potential savings by reducing just two risk factors (diabetes and hypertension) and their related comorbidity was estimated previously by Ormond and colleagues at $9 billion annually over one to two years and closer to $25 billion a year after 5 years or more, factoring in possible complications. True Health Initiative founder, at Yale University  Director and study co-author David L. Katz, MD, MPH, FACLM, pointed out that in addition to costs, another implication of the study results is an individual's access to healthcare if they have one or more of the chronic conditions. "Although insurers decide what qualifies as a pre-existing condition, all the chronic conditions used in this study except cognitive impairment are commonly included," he said. "Individuals with a pre-existing condition could be denied coverage or face higher premiums. While having a pre-existing condition might not affect coverage for adults eligible for Medicare, over half of all adults with multiple chronic conditions are ages 18 to 64 years." American College of Lifestyle Medicine President George Guthrie, MD, MPH, FACLM, said the study confirms the necessity for addressing the root cause of chronic conditions. "The evidence shows that the risks for chronic disease are rooted in lifestyle choices," he said. "More than ever, it is important to emphasize lifestyle medicine as the first treatment option for preventing, treating, and in some cases, reversing the cause of chronic conditions. If we can help people with chronic conditions, we can add years to their life and life to their years, as well as lower the ever-increasing costs of healthcare for everyone."     Physical athletes' visual skills prove sharper than action video game players University of Waterloo (Canada), October 7, 2021 Athletes still have the edge over action video gamers when it comes to dynamic visual skills, a new study from the University of Waterloo shows. For an athlete, having strong visual skills can be the difference between delivering a peak performance and achieving average results. "Athletes involved in sports with a high-level of movement—like soccer, football, or baseball—often score higher on dynamic visual acuity tests than non-athletes," said Dr. Kristine Dalton of Waterloo's School of Optometry & Vision Science. "Our research team wanted to investigate if action video gamers—who, like e-sport athletes, are regularly immersed in a dynamic, fast-paced 2D video environment for large periods of time—would also show superior levels of dynamic visual acuity on par with athletes competing in physical sport." While visual acuity (clarity or sharpness of vision) is most often measured under static conditions during annual check-ups with an optometrist, research shows that testing dynamic visual acuity is a more effective measure of a person's ability to see moving objects clearly—a baseline skill necessary for success in physical and e-sports alike.  Using a dynamic visual acuity skills-test designed and validated at the University of Waterloo, researchers discovered that while physical athletes score highly on dynamic visual acuity tests as expected, action video game players tested closer to non-athletes.  "Ultimately, athletes showed a stronger ability to identify smaller moving targets, which suggests visual processing differences exist between them and our video game players," said Alan Yee, a Ph.D. candidate in vision science. All participants were matched based on their level of static visual acuity and refractive error, distinguishing dynamic visual acuity as the varying factor on their test performance. These findings are also important for sports vision training centers that have been exploring the idea of developing video game-based training programs to help athletes elevate their performance. "Our findings show there is still a benefit to training in a 3D environment," said Dalton. "For athletes looking to develop stronger visual skills, the broader visual field and depth perception that come with physical training may be crucial to improving their dynamic visual acuity—and ultimately, their sport performance."  The study, Athletes demonstrate superior visual dynamic visual acuity, authored by Waterloo's School of Optometry & Vision Science's Dalton, Yee, Dr. Elizabeth Irving and Dr. Ben Thompson, was recently published in the journal Optometry and Vision Science.     Probiotic Akkermansia muciniphila and environmental enrichment reverse cognitive impairment associated with high-fat high-cholesterol consumption University of Oviedo (Spain), September 8, 2021 Nonalcoholic steatohepatitis (NASH) is one of the most prevalent diseases globally. A high-fat, high-cholesterol (HFHC) diet leads to an early NASH model. It has been suggested that gut microbiota mediates the effects of diet through the microbiota–gut–brain axis, modifying the host's brain metabolism and disrupting cognition. Here, we target NASH-induced cognitive damage by testing the impact of environmental enrichment (EE) and the administration of either Lacticaseibacillus rhamnosus GG (LGG) or Akkermansia muciniphila CIP107961 (AKK). EE and AKK, but not LGG, reverse the HFHC-induced cognitive dysfunction, including impaired spatial working memory and novel object recognition; however, whereas AKK restores brain metabolism, EE results in an overall decrease. Moreover, AKK and LGG did not induce major rearrangements in the intestinal microbiota, with only slight changes in bacterial composition and diversity, whereas EE led to an increase in Firmicutes and Verrucomicrobia members. Our findings illustrate the interplay between gut microbiota, the host's brain energy metabolism, and cognition. In addition, the findings suggest intervention strategies, such as the administration of AKK, for the management of the cognitive dysfunction related to NASH. In this study, we described cognitive, brain metabolism, and microbiota alterations associated with high-fat and high-cholesterol consumption. In addition, we clearly showed that environmental enrichment and A. muciniphila CIP107961 restore cognitive dysfunction. Furthermore, we revealed that cognitive improvement is associated with differential effects of environmental enrichment and this strain of A. muciniphila on brain metabolism and gut microbiota. Finally, we discovered that restored cognitive function was associated with the administration of A. muciniphila CIP107961, but not L. rhamnosus GG, which may be clinically relevant when selecting probiotics for treating HFHC-derived pathologies. In conclusion, the microbiota and cognition are intimately connected through the gut–brain axis, and in HFHC pathologies they can be influenced by environmental enrichment and A. muciniphila CIP107961 administration. Cognitive improvement was accompanied by changes in brain metabolic activity and gut microbial composition analysis, pointing to specific microbiota targets for intervention in diet-induced pathologies. However, some mechanisms other than major changes in microbiota composition and the combined effect of environmental enrichment and A. muciniphila administration, which we identified in this study, may also be biologically relevant and will need to be investigated in future studies due to their relative contributions to the selection of effective treatments for patients.           

Alessandro Nivola's career trajectory is proof that artists, especially actors, must continue to adjust ambitions and dream big. On first the stage and then the screen, Alessandro carved out a character actor niche, morphing into roles “very unlike” himself, as he tells Backstage. “It's part of staying alive, always having new cravings and goals and longings.... One has to battle those feelings on some level and try and feel grateful for what you have.” A Boston native who studied acting at regional theaters and as an undergrad at Yale University, Alessandro fulfilled his dreams of a stage career as a young adult, award-nominated for his Broadway debut opposite Helen Mirren in “A Month in the Country.” After watching his theater peers cross over to Hollywood, he did the same with “Face/Off,” and appeared in “Laurel Canyon,” “Junebug,” “Selma,” “A Most Violent Year,” “The Wizard of Lies,” “Disobedience,” and in many more character roles. Tony-nominated for “The Elephant Man” and a SAG Award winner for “American Hustle,” he also runs the company behind “Doll & Em” and “To Dust,” King Bee Productions, with his wife, actor Emily Mortimer. Alessandro now stars as Dickie Moltisanti, one of his first leading roles, in Warner Brothers' new prequel to “The Sopranos” from David Chase, “The Many Saints of Newark.” Read more about the buzzy film at backstage.com: https://bit.ly/3a3CbSo --- Backstage has been the #1 resource for actors and talent-seekers for 60 years. In the Envelope, Backstage's podcast, features intimate, in-depth conversations with today's most noteworthy film, television, and theater actors and creators. This is your guide to every aspect of acting, from voiceover and commercial work to casting directors, agents, and more. Full of both know-how and inspiration, In the Envelope airs weekly to cover everything from practical advice on navigating the industry, to how your favorite projects are made, to personal stories of success and failure alike. Join host Jack Smart, Awards Editor at Backstage, for this guide on how to live the creative life from those who are doing it every day: https://bit.ly/2OMryWQ Follow Backstage and In the Envelope on social media: - https://www.facebook.com/backstage - https://www.twitter.com/backstage - https://www.twitter.com/intheenvelope - https://www.instagram.com/backstagecast Looking to get cast? Subscribe here: www.backstage.com/subscribe Browse Backstage casting listings: https://bit.ly/3mth68e Check out our community-driven virtual programming, The Slate: https://bit.ly/2WDNXf0 Backstage stands in solidarity with the Black Lives Matter movement: https://bit.ly/3cuMBt5 Special thanks to... - Host: Jack Smart - Producer: Jamie Muffett - Social media: Katie Minard - Design: Mark Stinson, Caitlin Watkins - Additional support: Christine McKenna-Tirella, Kasey Howe, Samantha Sherlock, Benjamin Lindsay, Oriella St. Louis

I don't even know if there are diners in the Canary Islands, but I do know that this week's guest, Geneviève Pépin, slid into this diner all the way from off the coast of Morocco. Geneviève and I started off discussing the magical foods that are poutine (because she's from Quebec City) and arepas (because they are delicious). Then she told me about how she went from being a loner as a child who wanted to be an artist to getting lost in the corporate world. In her 20s she became a voracoius traveler and wound up studying and then working in China for 6 years! I loved hearing about her experience in China, what she loved about the culture there, and what surprised her. Because she has lived in many places, Geneviève calls herself a free agent of cultural norms, so naturally, I had to ask how one does that. We then discussed some of her professional careers. She talked about getting your dream job and then realizing it was not right for her and then knowing when to leave. It was fascinating hearing her talk about coming to terms with your control issues and understanding your relationship with control. And we finished up by going back and forth about, as a coach, how do you spark change? Loved this one y'all!   . About the Guest: (Bio, Personal Links, Resource Links)   Geneviève Pépin is passionate about helping people go from busy & stressed to happy & productive, as a result of her own journey in the professional world. She is an accredited life coach (IAPC&M), certified mindset specialist, productivity and leadership development coach (Fortune 500 companies), and improv facilitator. Before coaching, Geneviève built her career internationally in event management and marketing, living, working, and traveling in 20 countries, in four different languages. She likes to enjoy a black espresso and a good laugh with friends, practice improv comedy, and spend time with her husband and two dogs in the beautiful Canary Islands that she calls home.   Connect with Geneviève and learn more: LinkedIn: https://bit.ly/GenLIProfile Website: https://nettolacoaching.com/ About the Host:  Friends! Here's a somewhat stuffy bio of me:   I am an author, professional speaker, coach, host, and entrepreneur. My first book, Leading Imperfectly: The value of being authentic for leaders, professionals, and human beings, is available wherever people buy books. I speak internationally to willing and unwilling attendees about authenticity, vulnerability, and leadership. My clients include American Express, General Electric (GE), Accenture, Yale University, The Ohio State University, and many others. As a speaker, I am doing the two things I loves the most: making people think and making people laugh!  I host my own events multiple times a year. They are 2-day events called Living Imperfectly Live (and sometimes they are 1-day virtual events). They are a space where humans from every walk of life can come together to be part of a community on the pursuit of badassery. The goal is to help attendees start living the life we say we want to live. Alas, you're here because of an idea I had a number of years ago and didn't think I was good enough to pull it off. I finally acted on it and alas Diner Talks with James was born! As you can see from what I do in my professional life, Diner Talks is alligned with everything I believe in and teach.  If this wasn't dry enough, and you would like to know more info about my speaking, events, or coaching feel free to check out my website: JamesTRobo.com. Let's Be Friends on Social Media! Instagram: https://www.instagram.com/jamestrobo (https://www.instagram.com/jamestrobo) Facebook: https://www.facebook.com/jamestrobo (https://www.facebook.com/jamestrobo) LinkedIn: https://www.linkedin.com/in/jamesrobilotta/ (https://www.linkedin.com/in/jamesrobilotta/) YouTube: https://www.youtube.com/JamesRobilottaCSP...

Roshan Sethi is a screenwriter and is a radiation oncologist at the Dana Farber Cancer Institute in Boston. He graduated from Yale University and Harvard Medical School where he began his screenwriting career. He co-created Fox's The Resident and has written for TV shows including Code Black and Black Box. Recently he wrote and directed 7 Days, a rom-com that was featured this year at the Tribeca Film Festival. Bon and Sethi talk about the parallels between screenwriting and medicine, writing as an act of empathy, and the art of storytelling.

We discuss woke capitalism, interdisciplinary pursuits, entrepreneurship, the biotech and asset management industries, the need for passion in life, happiness, career changes, and life stages among other topics. _______________________________________ Vivek is the author of the recently released New York Times bestseller book Woke, Inc.: Inside Corporate America's Social Justice Scam. He founded and served as executive chairman of Roivant Sciences, a biopharmaceutical company specializing in the use of technology to drug development. In 2016, Forbes Magazine listed Vivek as the 24th richest American entrepreneur under 40 (net worth of $600 million). He holds a Harvard undergraduate degree in biology and a Yale University law degree. _______________________________________ If you appreciate my work and would like to support it: https://subscribestar.com/the-saad-truth https://patreon.com/GadSaad https://paypal.me/GadSaad _______________________________________ This chat was posted earlier today (October 6, 2021) on my YouTube channel as THE SAAD TRUTH_1309: https://youtu.be/uy5cee96yAE _______________________________________ The Parasitic Mind: How Infectious Ideas Are Killing Common Sense (paperback edition) was released on October 5, 2021. Order your copy now. https://www.amazon.com/Parasitic-Mind-Infectious-Killing-Common/dp/162157959X/ref=tmm_hrd_swatch_0?_encoding=UTF8&qid=&sr= https://www.amazon.ca/Parasitic-Mind-Infectious-Killing-Common/dp/162157959X https://www.amazon.co.uk/Parasitic-Mind-Infectious-Killing-Common/dp/162157959X _______________________________________ Please visit my website gadsaad.com, and sign up for alerts. If you appreciate my content, click on the "Support My Work" button. I count on my fans to support my efforts. You can donate via Patreon, PayPal, and/or SubscribeStar. _______________________________________ Dr. Gad Saad is a professor, evolutionary behavioral scientist, and author who pioneered the use of evolutionary psychology in marketing and consumer behavior. In addition to his scientific work, Dr. Saad is a leading public intellectual who often writes and speaks about idea pathogens that are destroying logic, science, reason, and common sense. _______________________________________  

Building connections is a critical skill set for career success. Most successful people would agree that the popular catchphrase, "it's who you know, not what you know," rings true in daily life. The fact is, “who you know” might matter more, or at least, be just as important as what you know in getting professional opportunities. Our guest, Rosa Gonzalez Welton, Director of Product Management, Digital Acquisition, Growth and Customer Success at ServiceNow, shares her career journey and why she believes creating and building connections is the key to learning, growing, and fostering relationships. As Director of Product Management, Rosa is responsible for creating experiences across the end-to-end customer journey, from acquisition and growth, through to customer success. Rosa also created her own LeanIn Circle, for Latinas working in tech, a safe space for real talk, inspiration, and support. In this episode, Rosa shares why the best way to learn is by seizing opportunities, the benefits of investing in yourself, her decision framework, and how she gained access to influential leaders, sponsors, and mentors. Visit https://www.iambeyondbarriers.com where you will find show notes and links to all the resources in this episode, including the best way to get in touch with Rosa. Highlights: [02:22] Rosa's story [04:30] Jumping at opportunities to learn [06:13] Gaining clarity on your career path [08:26] The ROI of investing in yourself [10:24] The importance of community [15:07] Pushing forward through barriers [16:58] Rosa's decision framework [18:34] Gaining access to influential leaders, sponsors, and mentors [20:43] Asking for help [22:29] Rosa's daily success habits [24:39] Staying ahead of the curve Quotes: “Sometimes, in an organization, you're in a situation where you're just not going to win. Go where you're valued.” – Rosa Welton “People generally want to help. There is a benefit they get simply by mentoring or coaching others.” – Rosa Welton “The big picture in trying something new is that it's going to somehow open the door for you to know if that's the direction you want to go or a direction you don't want to go in.” - Rosa Welton “When others are complimenting you or your work, listen to them with an open mind, it will help you to find clarity on your strengths.” - Rosa Welton “It's important to know when to move on from a company or role. It is equally important to be intentional about where you are going next.” - Rosa Welton About Rosa Welton: As Director of Product Management, Digital Acquisition, Growth and Customer Success at ServiceNow, Rosa Gonzalez Welton is responsible for creating experiences across the end-to-end customer journey, from acquisition and growth, through to customer success. Prior to joining ServiceNow in 2019, Rosa spent 7 years with eBay where she held leadership positions in the consumer selling business; leading teams in product management, strategy, and product marketing. Her experiences building consumer marketplaces include roles at Walmart Labs and TrueCar, where she was an instrumental part of the team that launched the car shopping platform. Earlier in her career, she worked at Forrester Research, the Food Network, and Hearst Interactive. Rosa is originally from Los Angeles and holds an MBA from UCLA Anderson and a BA from Yale University. In her free time Rosa sparks connections between people around her dinner table in a drive to cure loneliness. Links: Website: https://www.rosawelton.com/ LinkedIn: https://www.linkedin.com/in/rwelton/ Latinas In Tech: https://leanin.org/circles/latinas-in-tech

We discuss speech codes, the roots of political correctness, cancel culture, postmodernism, the importance of reading and of pursuing a liberal education among many other topics.   Michael hosts The Michael Knowles Show at the Daily Wire, and is the author of two books, the satirical empty book Reasons to Vote for Democrats and the recently released Speechless: Controlling Words, Controlling Minds. He is an alumnus of Yale University. _______________________________________ At roughly the 59:21 mark, I referred to PodTV with whom I had an exclusive deal at the time but that has now been terminated by mutual agreement. The Buck Sexton chat aired on PodTV's platform originally but will eventually be uploaded on my platforms (along with all other episodes that originally aired on PodTV). The current chat with Michael Knowles is not part of the episodes that originally aired on PodTV. _______________________________________ If you appreciate my work and would like to support it: https://subscribestar.com/the-saad-truth https://patreon.com/GadSaad https://paypal.me/GadSaad _______________________________________ This chat was posted earlier today (October 4, 2021) on my YouTube channel as THE SAAD TRUTH_1307: https://youtu.be/62ZtJ_uFwu0 _______________________________________ The Parasitic Mind: How Infectious Ideas Are Killing Common Sense was released on October 6, 2020. Order your copy now. https://www.amazon.com/Parasitic-Mind-Infectious-Killing-Common/dp/162157959X/ref=tmm_hrd_swatch_0?_encoding=UTF8&qid=&sr= https://www.amazon.ca/Parasitic-Mind-Infectious-Killing-Common/dp/162157959X https://www.amazon.co.uk/Parasitic-Mind-Infectious-Killing-Common/dp/162157959X _______________________________________ Please visit my website gadsaad.com, and sign up for alerts. If you appreciate my content, click on the "Support My Work" button. I count on my fans to support my efforts. You can donate via Patreon, PayPal, and/or SubscribeStar. _______________________________________ Dr. Gad Saad is a professor, evolutionary behavioral scientist, and author who pioneered the use of evolutionary psychology in marketing and consumer behavior. In addition to his scientific work, Dr. Saad is a leading public intellectual who often writes and speaks about idea pathogens that are destroying logic, science, reason, and common sense. _______________________________________

General Stanley McChrystal retired in July 2010 as a four-star general in the U.S. Army. His last assignment was as the commander of the International Security Assistance Force and as the commander of the U.S. forces in Afghanistan. He had previously served as the director of the Joint Staff and as the commander of the Joint Special Operations Command. The author of My Share of the Task, Team of Teams, and Leaders, he is currently a senior fellow at Yale University's Jackson Institute for Global Affairs and the cofounder of theMcChrystal Group, a leadership consulting firm.

My guest this week is Rory Stewart, British academic, diplomat, explorer, author, soldier, and politician. Rory is a Senior Fellow at Yale University's Jackson Institute for Global Affairs, where he teaches politics and international relations. He has served as a Minister in four different departments of the UK government, including Secretary of State for International Development. He resigned from this role when Boris Johnson became Prime Minister. He was also a Member of Parliament. He has walked across Afghanistan, Iran, Pakistan, India, and Nepal, and written a best selling book, The Places In Between, about his experiences. Rory's Books Tristram Shandy by Lawrence Sterne, 1759 Anna Karenina by Leo Tolstoy, 1877 The Civilisation of the Renaissance in Italy by Jacob Burckhardt, 1860 The Power and the Glory by Graham Greene, 1940 The Master and his Emissary by Ian McGilchrist, 2009 Learn more about your ad choices. Visit podcastchoices.com/adchoices

Text LEARNERS to 44222 for more... Full show notes at www.LearningLeader.com Twitter/IG: @RyanHawk12    https://twitter.com/RyanHawk12 General Stanley McChrystal retired in July 2010 as a four-star general in the U.S. Army. His last assignment was as the commander of the International Security Assistance Force and as the commander of the U.S. forces in Afghanistan. He had previously served as the director of the Joint Staff and as the commander of the Joint Special Operations Command. The author of My Share of the Task, Team of Teams, and Leaders, he is currently a senior fellow at Yale University's Jackson Institute for Global Affairs and the co-founder of the McChrystal Group, a leadership consulting firm. Notes: Stan's mentor for his military career and still to this day: an Army officer with a thick southern accent, Major John Vines. His advice: “If there are 3 people responsible for feeding the dog, the dog is going to starve.” Stan graduated from West Point 31 years after his father did. Major General George Smith Patton (General George Patton's son) handed him his diploma. Stan wondered at that moment, what kind of leader you wanted to be. And he came up with, “a good one.” Now the more fundamental question is “What do good leaders do?” Instead of just being a good leader, Stan desires to be an effective leader. Effective leaders: Tactically competent Are morally good Respected They create an environment where others want to follow They shape how people think and behave People that others want to follow Have high standards Risk: in reality, risk is neither mathematical nor finite. Its impact depends to a great extent on how we perceive, process, and respond. A healthy risk immune system successfully executes 4 imperatives: Detect, Assess, Respond, and Learn "Risk comes at you from out of the blue, from every angle, when least convenient. There is a cost in becoming overly focused on risk and another at ignoring them. And the sweet spot between the two extremes moves with the circumstances around you.” “I chose a soldier's life for many reasons, one of which was the desire to perceive myself as a courageous risk taker. I liked the idea of taking risks that others would not.” Threat x Vulnerability = Risk Risk is an eternal challenge. But trying to anticipate or predict every possible risk is a fool's errand. The key is to understand how we need to think about risk, and to then respond appropriately. Rather than living in dread of things we often can't anticipate, duck, or dodge – we must remember these five key insights. Look Inward: The greatest risk to us is us. It's Up to Us: We have a risk immune system Be holistic: It's the system. Make it work Balance: The muscles you exercise will be strong: those you ignore will be vulnerabilities Risk is always with us, and it's our responsibility to make our teams ready for it When taking command of the 2nd Ranger Battalion, Stan, along with the leaders of the unit, established The foundational skills - They called them the big 4: Physical conditioning Marksmanship Medical Skills Small Unit Drills But even before mastering basic skills, grounding both individuals and organizations with answers to the most basic questions that relate to the narrative is essential: What are our values? What exactly do we do? And why do we do it? What is expected of each of us? What went wrong with our response to COVID-19? 50 states operated separately instead of a united response "We weren't unified" "Our leaders did not communicate effectively." "You have to act before the population sees the requirement for it." Have a front-line obsession - Stan was known for going on the front lines with his soldiers. As leaders, we should do the same with our teams. Be on the front lines to: See how it's done with your own eyes, not just reports They need to see you go. They'll appreciate it It helps create your self-identity The new hybrid model of in-office and at-home working... Be intentional Use technology Understand what you're not doing Don't get lazy How to deal with imposter syndrome? Ask, "What do I know?" "What's my responsibility?" "You have to fight that crisis of confidence." Excellence = Be less flexible on your basic values Be flexible with how a problem gets solved

Nine justices hold tremendous power. Advocates on the left see a Supreme Court out of touch with the electorate, obstructed by partisan interests, and rendered illegitimate by years of controversial appointments. But those opposed believe dramatically changing one of the three core pillars of American government would undermine the court's legitimacy.  Intelligence Squared U.S. in partnership with The Newt and Jo Minow Debate Series at Northwestern Pritzker School of Law asks: Should we expand the Supreme Court?   Arguing in favor of the motion is Dhalia Lithwick, legal commentator and Slate's Amicus podcast host with Tamara Brummer of advocacy group Demand Justice. Arguing against the motion is Carter Phillips, a Supreme Court and appellate litigator with Akhil Reed Amar, a constitutional law scholar and professor at Yale University. Emmy award-winning journalist John Donvan moderates.  Learn more about your ad choices. Visit megaphone.fm/adchoices

General Stanley McChrystal — Mastering Risk: A User's Guide | Brought to you by Kettle & Fire high quality, tasty, and conveniently packaged bone broths; Eight Sleep's Pod Pro Cover sleeping solution for dynamic cooling and heating; and ShipStation shipping software. More on all three below.General Stanley McChrystal (@stanmcchrystal) was called “one of America's greatest warriors” by Secretary of Defense Robert Gates. Having held leadership and staff positions in the Army Special Forces, Army Rangers, 82nd Airborne Division, the XVIII Army Airborne Corp, and the Joint Staff, McChrystal became commander of JSOC in 2003, responsible for leading the nation's deployed military counterterrorism efforts around the globe. His leadership is credited with the 2003 capture of Saddam Hussein and the 2006 locating and killing of Abu Musab al-Zarqawi, the leader of al-Qaeda in Iraq. In June 2009, McChrystal received his fourth star and assumed command of all international forces in Afghanistan.General McChrystal founded the McChrystal Group in January 2011, an advisory services firm that helps businesses challenge the hierarchical “command and control” approach to organizational management.He is a senior fellow at Yale University's Jackson Institute for Global Affairs, where he teaches a course on leadership, and he is the author of the bestselling leadership books My Share of the Task: A Memoir; Team of Teams: New Rules of Engagement for a Complex World; and Leaders: Myth and Reality. His new book is Risk: A User's Guide. He is also the co-host (with former Navy SEAL Chris Fussell) of the No Turning Back podcast, where they explore the future of leadership and teams with the world's most consequential leaders.Please enjoy!This episode is brought to you by Kettle & Fire! Kettle & Fire makes one of the highest quality, tastiest, and most conveniently packaged bone broths on the market, and I have a huge collection of their broths on my kitchen counter for easy access. I've been a fan ever since 2015, when podcast guest and ketogenesis expert Dr. Dominic D'Agostino introduced me to the company. Their products fit me and my lifestyle extremely well: bone broth is a great ‘one-stop shop' for low-carb, high-protein nutrition, and bone broth makes an excellent lower-calorie breakfast that requires no prep.It's one of the simplest ways to get many of the nutrients I need, and I simply feel better when broth is a regular part of my diet. You can save 25% off your order by going to KettleAndFire.com/Tim and using code TIM at checkout.*This episode is also brought to you by ShipStation. Do you sell stuff online? Then you know what a pain the shipping process is. ShipStation was created to make your life easier. Whether you're selling on eBay, Amazon, Shopify, or over 100 other popular selling channels, ShipStation lets you access all of your orders from one simple dashboard, and it works with all of the major shipping carriers, locally and globally, including FedEx, UPS, and USPS. Tim Ferriss Show listeners get to try ShipStation free for 60 days by using promo code TIM. There's no risk, and you can start your free trial without even entering your credit card info. Just visit ShipStation.com, click on the microphone at the top of the homepage, and type in TIM!*This episode is also brought to you by Eight Sleep! Eight Sleep's Pod Pro Cover is the easiest and fastest way to sleep at the perfect temperature. It pairs dynamic cooling and heating with biometric tracking to offer the most advanced (and user-friendly) solution on the market. Simply add the Pod Pro Cover to your current mattress and start sleeping as cool as 55°F or as hot as 110°F. It also splits your bed in half, so your partner can choose a totally different temperature.And now, my dear listeners—that's you—can get $250 off the Pod Pro Cover. Simply go to EightSleep.com/Tim or use code TIM. *If you enjoy the podcast, would you please consider leaving a short review on Apple Podcasts? It takes less than 60 seconds, and it really makes a difference in helping to convince hard-to-get guests. I also love reading the reviews!For show notes and past guests, please visit tim.blog/podcast.Sign up for Tim's email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Laurie Santos (Cognitive scientist! Host of The Happiness Lab! Professor of Psychology at Yale University!) makes it weird