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White House says continued mass migration from the Third World is literally unsustainable, Trump doubles down on calling Tim Walz "retarded," the surviving D.C. Guardsman shows signs of recovery, Mark Kelly still won't disavow sedition, Keith Ellison caught on tape cozying up to future Feeding Our Future fraud defendants, home sellers slashing prices by record amounts, FDA quietly admits COVID shots killed kids, Joe Rogan says "Christianity works," Alex Jones preaches repentance, and a warning that college football is on the fast track to a Cloward-Piven collapse. The AM Update, Aaron McIntire, Trump immigration, reverse migration, Tim Walz, Afghan attack, National Guard, Mark Kelly sedition, Keith Ellison scandal, housing market, COVID vaccine deaths, Joe Rogan Christian, Alex Jones repent, college football collapse
President Trump cracks down on migration from third-world countries following the attack on National Guardsmen in D.C. Minnesota Gov. Tim Walz (D) thought he had a gotcha moment on Trump, after the president called him retarded. The FDA admits that COVID shots killed at least 10 children. CNN tries a new attack on the president, that he's targeting female journalists. Chad Prather and Adam Johnson join the panel. ► Subscribe to "Sara Gonzales Unfiltered"!https://www.youtube.com/@SaraGonzalesUnfiltered?sub_confirmation=1Today's Sponsors: ► Jase MedicalRight now, you can easily give the gift of real emergency preparedness with 20% off Jase gift cards when you use promo code SARA at https://www.jase.com. ► MDHearing Go to https://www.ShopMDHearing.com and use promo code SARA to get a pair of hearing aids for JUST $297! Plus, they're adding a free extra charging case, a $100 value, just for my listeners. ► American GiantBuy American today at https://www.American-Giant.com. Save 20% when you use code SARA at checkout. ► BlazeTVJoin today at https://www.blazetv.com/SARA and get $30 off right now. Learn more about your ad choices. Visit megaphone.fm/adchoices
Prediabetes is common in the U.S. — around 1 in 3 people have it. And many people may not know they have it. But last year, the FDA approved the first over-the-counter continuous glucose monitor. Since then, more people without diabetes have started checking their blood glucose levels. Diabetologist and University of California, San Francisco professor of medicine Dr. Sarah Kim shares the science behind blood glucose with host Emily Kwong. Check out more of NPR's coverage about continuous glucose monitors.Interested in more science of the human body? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy
Nicolle Wallace is joined by Senator Richard Blumenthal to discuss Congress' investigation into the military operations in the Caribbean after it was revealed that Defense Secretary Pete Hegseth gave the order to “kill everyone” aboard a vessel suspected to be transporting drugs.Later, Nicolle covers the mysterious MRI Trump received in October, which, when asked by a reporter, Trump said he had no idea which body part it was for. As Trump faces the increased fatigue that comes with aging, the FDA put out a memo that suggests it's going to get stricter when approving vaccines.For more, follow us on Instagram @deadlinewhTo listen to this show and other MS NOW podcasts without ads, sign up for MS NOW Premium on Apple Podcasts. For more from Nicolle, follow and download her podcast, “The Best People with Nicolle Wallace,” wherever you get your podcasts.To listen to this show and other MS podcasts without ads, sign up for MS NOW Premium on Apple Podcasts. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
In a leaked memo over the weekend, our country’s FDA vaccine chief stated that AT LEAST 10 children have died after, and because of receiving COVID-19 vaccinations. The medical community has largely responded with not only skepticism, but a demand for proof to back up what the FDA says is a “profound revelation." The memo goes on to blame the Biden administration for coercing “healthy young children” into having these vaccinations “that could result in death.”See omnystudio.com/listener for privacy information.
In a leaked memo over the weekend, our country’s FDA vaccine chief stated that AT LEAST 10 children have died after, and because of receiving COVID-19 vaccinations. The medical community has largely responded with not only skepticism, but a demand for proof to back up what the FDA says is a “profound revelation." The memo goes on to blame the Biden administration for coercing “healthy young children” into having these vaccinations “that could result in death.”See omnystudio.com/listener for privacy information.
In a leaked memo over the weekend, our country’s FDA vaccine chief stated that AT LEAST 10 children have died after, and because of receiving COVID-19 vaccinations. The medical community has largely responded with not only skepticism, but a demand for proof to back up what the FDA says is a “profound revelation." The memo goes on to blame the Biden administration for coercing “healthy young children” into having these vaccinations “that could result in death.”See omnystudio.com/listener for privacy information.
This podcast is brought to you by Outcomes Rocket, your exclusive healthcare marketing agency. Learn how to accelerate your growth by going to outcomesrocket.com Innovation is moving faster than the law, and investors are racing to keep up. In this episode, Brian Bewley, a partner in the Life Sciences and Health Industry group at Reed Smith, discusses how rapid technological advancements are reshaping healthcare and the life sciences faster than current regulations can keep pace. He explains how shifting federal policies, tariff disruptions, and turnover at key agencies, such as the FDA and HHS, have created uncertainty for investors. Brian also discusses how state-level laws are making it harder for private equity to fund healthcare innovation, and why that could slow progress. Still, he sees growing optimism as investors engage policymakers and prepare for a stronger market in 2026. Tune in to learn how legal, regulatory, and investment forces are converging to shape the future of healthcare innovation! Resources Connect with and follow Brian Bewley on LinkedIn, or reach out via email. Follow Reed Smith LLP on LinkedIn and visit their website.
The FDA's vaccine chief says the agency plans to tighten approval standards for COVID-19 vaccines, citing concerns about potential risks for children. In a leaked memo, Dr. Vinay Prasad says a review of records links 10 children's deaths to the COVID vaccine. He did not provide data to support the claim. CBS News medical contributor Dr. Celine Gounder explains what to know. At a pretrial hearing in the state case against Luigi Mangione, his lawyers are expected to argue some key evidence against him should not be allowed at trial. Mangione is accused of killing UnitedHealthcare CEO Brian Thompson nearly a year ago. There have been nearly 1.5 million reports of fraud so far this year, which is up from 1.3 million for the same period last year. Ash-har Quraishi got a behind-the-scenes look at VISA's high-tech cyber fusion center in Virginia to see how it's fighting fraud. Actor and comedian Richie Moriarty talks with "CBS Mornings" about the fifth season of the comedy series "Ghosts," what's next for his character and how the cast has bonded. When Marianne Baumgarten was 8 years old she was supposed to be a flower girl in a family wedding, but got sick just before. Decades later, an unexpected friendship that started during the pandemic would lead to her decades-old wish coming true. David Begnaud reports. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices
Did you know the FDA just reversed 23 years of misinformation about hormone therapy? In this powerful episode, I'm breaking down what this landmark ruling means for every woman, and why an entire generation was robbed of the opportunity to protect their health. This is vindication, but it also opens up critical questions about what comes next and how you can take control of your hormone health today. I'm sharing the complete roadmap to natural hormone balancing and bioidentical hormone replacement, including what your doctor isn't telling you about testing, metabolism, and the real foundations that make hormones work. You'll Discover: ● Why the FDA's recent ruling is a game-changer (and what it means for your health decisions!) ● The truth about menopause: it's not a disease, but leaving it untreated accelerates aging ● How estrogen affects every organ system in your body (except two cells!) and why losing it impacts more than just reproduction ● Why "test, don't guess" is essential, and why timing matters for perimenopausal women ● The critical difference between bound and free hormones, and why urinary testing reveals what blood work can't ● The five foundational pillars that make or break your hormone health: nutrition, sleep optimization, stress management, strategic exercise, and toxin reduction ● Why putting hormones in a "dumpster fire" lifestyle won't work (and how to create the right environment for them to thrive!) ● How liver detoxification and hormone metabolism determine whether you'll feel great or symptomatic on HRT ● The specific exercise prescription for menopause: strength training, zone 2 cardio, and why over-exercising can backfire Ready to Take Control of Your Hormone Health? This transition requires new strategies and support, and you have more control than you think. Watch the full episode now, and share this with every woman who needs to know she has options!
This special episode is brought to you by Zoll RespicardiaIn this episode of SleepTech Talk, we explore the newest breakthroughs in treating Central Sleep Apnea (CSA).Our guest, Timothy Morgenthaler, MD, Professor and Vice Chair, Quality and Affordability at the Mayo Clinic, and past President of the American Academy of Sleep Medicine (AASM), helps explain the updated AASM treatment guidelines and how Transvenous Phrenic Nerve Stimulation (TPNS) is now recognized as an effective therapy for CSA.We also dive deep into the Remede implant, an FDA-approved TPNS device that stimulates the phrenic nerve to help patients breathe normally during sleep. Dr. Morgenthaler breaks down how it works, which patients may benefit most, and what the AASM's new recommendations mean for clinicians and patients going forward.⭐ Main topics we cover:What's new in the AASM guidelines for Central Sleep Apnea (2025 update)Why TPNS is now an accepted therapy for CSAHow the Remede implant works and who it helpsDifferences between obstructive, central, and complex sleep apneaReal-world impact of the updated guidelines on patient careWhere TPNS fits among PAP therapy, ASV, oxygen, medications, and other treatmentsWhether you're a sleep clinician, technologist, or someone affected by sleep apnea, this episode provides a clear, practical breakdown of the latest evidence-based options for CSA.Learn more about Remede athttps://remede.zoll.com/ ABOUT SLEEPTECH TALKSleepTech Talk brings together leaders in sleep medicine, technology, and innovation to explore the tools and trends shaping the future of sleep health.Catch the show on most podcast platforms or on YouTubewww.youtube.com/@sleeptechtalk Don't forget to Like, Share, and Comment! Subscribe to SleepTech Talk for more insights into sleep apnea, CPAP therapy, and innovations shaping the future of sleep care.Whether you're a sleep professional or a healthcare innovator, this episode explores the intersection of technology, patient care, and sleep medicine.Learn more about the show at https://www.sleeptechtalk.com/thetechroomCredits:Audio/ Video: Diego R Mannikarote; Music: Pierce G MannikaroteHosts: J. Emerson Kerr, Robert Miller, Gerald George MannikaroteCopyright: ⓒ 2025 SleepTech Talk ProductionsEpisode 112The views and opinions expressed by guests on SleepTech Talk are their own and do not necessarily reflect those of the podcast hosts or SleepTech Talk as a whole. This podcast is intended for educational and informational purposes only and should not be considered medical advice. Listeners are encouraged to consult with a qualified healthcare professional for any medical concerns or questions.Sleep apnea, obstructive sleep apnea, oral sleep appliance, inspire, surgery, sleep surgery, CPAP, AI, Artificial Intelligence
Join Dr. David and MTC as we interview Dr. Otto Dueno of Dayton Behavioral Care. Dr. Dueno's practice specializesin advanced interventions for treatment-resistant depression, including rTMS and Spravato (the new FDA-approved nasal formulation of Esketamine). We also provide a complete array of psychotherapy services, including EMDR, for patients with trauma-related needs.
AABP Executive Director Dr. Fred Gingrich is joined by Dr. Isaac Jumper, assistant professor and ambulatory clinician at Mississippi State University College of Veterinary Medicine. Jumper was the first author on a paper published in the Bovine Practitioner online first edition. This peer-reviewed journal published by AABP is open access. The target audience for the journal is the practicing cattle veterinarian and there are no publication fees for submissions. Find the journal at this link. The objective of this paper was to study the temporal consumption patterns of chlortetracycline (CTC)-medicated mineral supplement offered free choice to beef cows on pasture and test the effect of cow age on CTC-medicated mineral supplement intake. The study involved an adaptation period to acclimate cows to the SmartFeed units and a trial period to test the study objectives. During the 27-day adaptation period, 76% of cattle consumed any amount of the diet during the day and the average total intake was just under 8 kg per cow or 0.3 kg per day. During the 46-day trial period, 27% of cows across all pasture groups consumed any amount of CTC-medicated mineral with an average amount consumed of just under 41 grams per day. The average dose of CTC consumed was 0.53 mg/kg per day which is less than the labeled dose of 1.1 mg/kg. The authors identified variability between cows in consumption of CTC-medicated mineral. The mean number of consumption days was 12.5, the number of consecutive days the average cow visited the feeder was 1.6 and the average number of days between visits was 6 days. We discuss the implications for control of anaplasmosis with these results. The authors identified that in this study, feeding CTC-medicated mineral did not ensure that cows on free-choice pasture-based feeding programs did not consume the label dose of CTC. As the age of the cow increased, the frequency of visits decreased, and the total consumption of CTC-medicated mineral declined. Veterinarians who are utilizing CTC for control of anaplasmosis should be familiar with FDA regulations on the Veterinary Feed Directive, including dosing, the difference between hand-fed labels and free-choice administration, and the prohibition of extralabel drug use for medically important antimicrobials administered in feed. A pilot study investigating consumption patterns of chlortetracycline-medicated mineral supplement offered free choice to beef cows on pasture. (2025). The Bovine Practitioner, 60(1):1-11. https://doi.org/10.21423/bpj20269277 Questions and Answers: FDA Approved Free-Choice Feeding Options for Anaplasmosis Control in Cattle | FDA
Marty Makary breaks down how views on steroids and testosterone shifted from taboo to medical treatment. He explains why muscle mass predicts longevity, why the FDA is holding a forum on TRT, and how hormone therapy for women was wrongly discredited despite major benefits for heart health, bones, and quality of life.
Listen to Daily Global #News from Grecian Echoes WNTN 1550 AM - Nasdaq closes higher, but notches losing month despite Thanksgiving week rally- FDA will upend its approach to immunizations for respiratory illnesses, including flu vaccines
To learn more about the FDA draft guidance regarding clinical efficacy studies for biosimilars and interchangeability, click here. To read more about G's discussion with Sarah Yim, MD, from the FDA from the recent 2025 GRx+Biosims conference, click here. To read more on Yim's perspectives on biosimilar policy harmonization, click here.
Pensión Mujeres Bienestar llega a QR para mexicanas de 60 a 64 años FDA admite posibles muertes infantiles ligadas a vacunas Covid Más información en nuestro Podcast
On this episode of Vitality Radio, Jared welcomes homeopathy educator and advocate Paola Brown, president of Americans for Homeopathy Choice. Together, they break down what homeopathy really is, how it works, and why it continues to help families around the world—even when the mainstream medical world insists it “shouldn't.” Paola shares her personal healing story, practical guidance for beginners, simple ways parents can confidently use homeopathy for everyday acute issues, and when to seek support from a homeopath for chronic conditions. You'll also hear why the FDA has recently threatened access to homeopathic remedies and what Paola's organization is doing in Washington, D.C. to keep these safe, affordable remedies available for everyone. Jared and Paola discuss potency selection, how to identify the right remedy, and why homeopathy often succeeds where other natural tools don't—especially for children and even animals. If you've ever been curious, skeptical, or confused about homeopathy, this conversation makes the entire system feel approachable, actionable, and empowering. And if you're already a believer, you'll walk away with even more tools, stories, and insights to support your family's wellness—naturally and safely.Products:Ollois Homeopathic RemediesAdditional Information:PaolaBrown.com/freeHomeopathyChoice.org/freeTo schedule your Homeopathy Consultation with Amanda Kotter:Email Amanda@vitalitynutrition.comCall/Text 801-388-4133Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
Dr. Jack Cush reviews the news and reports from this past week on RheumNow.com, including reports on FDA resurrections, FM seasonal worsening, and do you fight switch or swap biologics in PsA TNFi nonresponders?
INTERVIEW G Edward Griffin Author and documentary filmmaker, G Edward Griffin joinsHow did he get into documentary filmmakingWhat caused him to change his mind about the UNWhat does the author of "The Creature from Jekyll Island" think about the future of money?Now that we've seen how BigPharma & the FDA have acted during the "pandemic" are we ready to learn about alternative cancer treatment from his book "A World Without Cancer"INTERVIEW "Just the Inserts" — Vetting Pharma & BigMed for Yourself & Others Alexandra, JustTheInserts.comLike many, Alexandra was reluctant to heed warnings from friends and family. And like many, vaccine injury got her attention. How do we educate ourselves and fight the fear and arguments from authority? Alexandra has an answer. My Answer to "Stop Looking for Perfection, Jesus Isn't On the Ballot" What do we say to friends and family that want us to drop our principles and vote for what they think is a lessor evil? Do we focus on WHO is right or WHAT is right? Unveiling the FBI's Dark Secrets, Church's Silence, and Political Hypocrisy - A Battle for America's Soul! Dive into the heart of controversy as FBI whistleblower Garrett O'Boyle stands up against the agency's dark misuse of power, revealing a shocking clash of ethics versus corruption. Uncover the moral silence in America's churches, as we question why religious leaders are mute in the face of modern injustices. Expose the political hypocrisy with TPUSA's Charlie Kirk, where public endorsements clash with Christian values, igniting a firestorm over political integrity. Finally, the GOP's timid dance around abortion post-Roe v. Wade, urging a call to arms for more courageous, ethical political action. Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
INTERVIEW G Edward Griffin Author and documentary filmmaker, G Edward Griffin joinsHow did he get into documentary filmmakingWhat caused him to change his mind about the UNWhat does the author of "The Creature from Jekyll Island" think about the future of money?Now that we've seen how BigPharma & the FDA have acted during the "pandemic" are we ready to learn about alternative cancer treatment from his book "A World Without Cancer"INTERVIEW "Just the Inserts" — Vetting Pharma & BigMed for Yourself & Others Alexandra, JustTheInserts.comLike many, Alexandra was reluctant to heed warnings from friends and family. And like many, vaccine injury got her attention. How do we educate ourselves and fight the fear and arguments from authority? Alexandra has an answer. My Answer to "Stop Looking for Perfection, Jesus Isn't On the Ballot" What do we say to friends and family that want us to drop our principles and vote for what they think is a lessor evil? Do we focus on WHO is right or WHAT is right? Unveiling the FBI's Dark Secrets, Church's Silence, and Political Hypocrisy - A Battle for America's Soul! Dive into the heart of controversy as FBI whistleblower Garrett O'Boyle stands up against the agency's dark misuse of power, revealing a shocking clash of ethics versus corruption. Uncover the moral silence in America's churches, as we question why religious leaders are mute in the face of modern injustices. Expose the political hypocrisy with TPUSA's Charlie Kirk, where public endorsements clash with Christian values, igniting a firestorm over political integrity. Finally, the GOP's timid dance around abortion post-Roe v. Wade, urging a call to arms for more courageous, ethical political action. Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
"Antibody–drug conjugates (ADCs) have three basic parts: the antibody part, the cytotoxic chemo, and the linker that connects the two. First, the antibody part binds to the target on the surface of the cell. Antibodies can be designed to bind to proteins with a very high level of specificity. That's what gives it the targeted portion. Then the whole thing gets taken up by the cell and broken down, which releases the chemotherapy part. Some sources will call this the 'payload' or the 'warhead.' That's the part that's attached to the 'heat-seeking' part, and that's what causes the cell death," Kenneth Tham, PharmD, BCOP, clinical pharmacist in general oncology at the University of Washington Medicine and Fred Hutchinson Cancer Center in Seattle, WA, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about antibody–drug conjugates. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by November 28, 2026. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge related to the mechanism of action of antibody–drug conjugates. Episode Notes Complete this evaluation for free NCPD. ONS Podcast™ episodes: Pharmacology 101 series Episode 303: Cancer Symptom Management Basics: Ocular Toxicities Episode 283: Desensitization Strategies to Reintroduce Treatment After an Infusion-Related Reaction ONS Voice articles: An Oncology Nurse's Guide to Cancer-Related Ocular Toxicities Antibody–Drug Conjugates Join the Best of Two Worlds Into One New Treatment Nursing Management of Adverse Events From Enfortumab Vedotin Therapy for Urothelial Cancer Oncology Nurses' Role in Translating Biomarker Testing Results The Pharmacist's Role in Combination Cancer Treatments ONS Voice drug reference sheets: Belantamab mafodotin-blmf Datopotamab deruxtecan-dlnk Enfortumab vedotin Fam-trastuzumab deruxtecan-nxki ONS book: Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice (second edition) ONS course: ONS Fundamentals of Chemotherapy and Immunotherapy Administration™ Clinical Journal of Oncology Nursing articles: Antibody–Drug Conjugates and Ocular Toxicity: Nursing, Patient, and Organizational Implications for Care Nurse-Led Grading of Antineoplastic Infusion-Related Reactions: A Call to Action Other ONS resources: Antineoplastic Administration Huddle Card Biomarker Database Chemotherapy Huddle Card Monoclonal Antibodies Huddle Card Association of Cancer Care Centers (ACCC) antibody–drug conjugates page Drugs@FDA Hematology/Oncology Pharmacy Association (HOPA) National Cancer Institute cancer drugs page Network for Collaborative Oncology Development and Advancement (NCODA) clinical resource library ACCC/HOPA/NCODA/ONS Patient Education Sheets website To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org Highlights From This Episode "The mechanism of action of the chemo itself depends on what agent or what 'warhead' is attached. Generally, [ADCs] have some kind of cytotoxic mechanism related to many of the chemotherapies that we use in practice, without attachment to the antibody. Some of them can be microtubule inhibitors, vinca alkaloids like vincristine. Some of them can be topoisomerase I (TOP1) inhibitors like irinotecan. Some can be alkylating agents that cause DNA breaks. So, again, looking back at the arsenal we have of cytotoxic chemo, these can all be incorporated into the ADCs." TS 5:54 "I want to talk about a case where the biomarker is being tested, but the biomarker isn't the target that you're looking for. One good case of this is a newer agent that was approved called datopotamab deruxtecan. The datopotamab portion is specific to a target called 'trophoblast cell surface antigen 2' (TROP2), which is expressed on the surface of many epithelial cancers. This agent was first approved in hormone receptor-positive, HER2-negative breast cancer, and received accelerated approval in patients with non-small cell lung cancer (NSCLC) with an EGFR mutation. ... The antibody looks for a target, TROP2. But in both of these cases—in the breast cancer and the NSCLC—you're testing for expression of different mutations or lack thereof. You're not looking for expression of TROP2. There's more research that needs to be done about the relationship between TROP2 expression and the presence or absence of these other biomarkers, but until we know more, we're actually testing for biomarkers that aren't the target of the ADC." TS 10:22 "There are common adverse advents to antibodies and chemo in general. Because we have both of these components, we want to watch out for the adverse effects of both of them. Antibodies, as with most proteins, can trigger an immune response or an infusion reaction. So, many ADCs can also cause hypersensitivity or infusion reactions. The rates of that are really variable and depend on the actual antibodies themselves. Then you have the cytotoxic component, the chemotherapy component, which has its own characteristic side effects. So, if we think of general chemo side effects—fatigue, nausea, bone marrow suppression, alopecia—these can [occur] with a lot of ADCs as well." TS 15:34 "The rate of ocular toxicity in [mirvetuximab soravtansine] is quite high. The manufacturer reports that this can occur in up to 60% of patients. With rates so high, the manufacturer recommends a preventive strategy. For this particular agent, [they] recommend patients have required eyecare. ... This ocular toxicity is something we do see in other ADCs that don't have the same target and don't necessarily have the same payload component. For example, tisotumab vedotin and again, datopotamab deruxtecan, can both cause ocular toxicities and both would have required ocular supportive care." TS 20:08 "Overall, I feel like the future is incredibly bright for these agents. There have only been around a dozen therapies approved by the U.S. Food and Drug Administration (FDA) despite this idea—the first agent came out in 2000. So, 25 years later, there are only around a dozen FDA-approved treatments. But there are so many more that are coming through the pipeline. And as we're discovering more biomarkers and developing more specialized antibodies, it's only natural that more ADCs will follow." TS 26:50
In this special live episode recorded at Sleep Medicine Disruptors in Austin, Texas, host Dr. Seema Khosla sits down with two standout innovators whose technologies captured the spirit of disruptive innovation in sleep medicine. Dr. Jason McKeown from Neurovalens and Dr. Onur Kilic from Bairitone Health present groundbreaking approaches to treating insomnia and personalizing obstructive sleep apnea therapy. Dr. McKeown, a neurologist, introduces his FDA-cleared non-pharmacological treatment for insomnia using vestibular nerve stimulation. He explains how the technology works, why stimulating nerves in this manner is safe, and how it differs from vagus nerve devices. The conversation explores the relationship with cognitive behavioral therapy for insomnia (CBT-I), addresses the placebo effect question, and clarifies whether this is a long-term solution or temporary intervention. Dr. McKeown discusses contraindications including pregnancy and Inspire therapy, potential side effects, and ideal patient populations. Dr. Kilic presents his sensor technology that enables non-invasive assessment of airway collapse location and severity—what he calls an "anatomic PSG." This innovation addresses a critical challenge: predicting which patients will respond to specific treatments like oral appliances, Inspire, or PAP therapy based on individual anatomical collapse patterns. Using a cheek-mounted sensor, the device identifies obstruction levels, differentiates between primary and secondary collapse sites, and detects collapse at the velopharyngeal level. The discussion explores whether this represents a scalable alternative to drug-induced sleep endoscopy (DISE), how it integrates with OSA endotyping, and practical applications during titration studies to identify optimal pressure ranges and guide combination therapies. Both innovators emphasize moving beyond one-size-fits-all approaches toward personalized, anatomy-based treatment selection. Whether you're interested in non-pharmacological insomnia treatments, precision medicine approaches to OSA, or the future of sleep diagnostics, this episode showcases innovative thinking driving the next generation of sleep medicine. Join us for this exciting live conversation from Sleep Medicine Disruptors.
Dr. Don and Professor Ben talk about the risks of feeding recalled sealed Byheart baby formula to a baby. Fedica text: Dr. Don - risky ☣️ Professor Ben - risky ☣️ ByHeart recalls organic baby formula amid infant botulism outbreak | AP News Infant Botulism Outbreak Linked to Infant Formula, November 2025 | Botulism | CDC Seven-Year Case-Control Study in California of Risk Factors for Infant Botulism - ScienceDirect Elevated incidence of infant botulism in a 17-county area of the Mid-Atlantic region in the United States, 2000–2019, including association with soil types | Applied and Environmental Microbiology Tyndallization - Wikipedia Outbreak Investigation of Infant Botulism: Infant Formula (November 2025) | FDA
The FDA has updated its stance on estrogen therapy, reversing decades of confusion from early WHI interpretations. New research and global data now show estrogen may support long-term health and reduce key chronic risks.This episode explains the FDA's updated guidance, what the WHI got wrong, and what current science reveals about heart health, brain function, diabetes risk, bone density, and breast cancer. We also break down synthetic progestins vs. bioidentical progesterone, why timing matters, and how Europe achieved better outcomes with HRT.Tune in to get clear, evidence-based insights so you can talk confidently with your provider and decide if hormone therapy fits your goals.Timestamps: 00:00 FDA Update 00:27 WHI Misinterpretation 01:05 Synthetic vs Bioidentical 02:14 Why Estrogen Was Blamed 03:12 Black Box Warning 04:48 New Research 06:10 Heart/Brain/Cancer Data 07:45 Europe's Approach 08:30 Progestins vs Progesterone 09:45 What It Means Today 10:45 Why Doctors Stopped HRT 11:30 FDA 2025 Review 12:28 Black Box Removal 13:25 Key Takeaways 14:05 How to Discuss HRTReady to talk through your options? Visit this link to learn more:https://www.alluremedical.com/Subscribe to the podcast and leave a 5-star review!Read the latest research and advice from the doctors at Allure Medical: https://www.alluremedical.com/books/ Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.LinkedIn: https://www.linkedin.com/in/charles-mok-4a0432114/ Instagram: https://www.instagram.com/alluremedicals/ Website: https://www.alluremedical.com/ YouTube: https://www.youtube.com/@AllureMedical TikTok: https://www.tiktok.com/@alluremedical Amazon Store: https://www.amazon.com/stores/Dr.-Charles-Mok/author/B0791M9FZQ?ref=ap_rdr&store_ref=ap_rdr&isDramIntegrated=true&shoppingPortalEnabled=true Join the Allure Medical Inner Circle Membership:https://www.alluremedical.com/inner-circle-membership/
It's our 100th episode! I celebrate this milestone with Karen Bradley, NP, discussing the biggest wins, most common questions, and key themes from nearly two years of podcasting about women's sexual health and menopause.We dive into the FDA's recent decision to remove the boxed warning from vaginal estrogen a huge victory for women's health advocacy. This warning has prevented countless women from getting treatment for painful sex, recurrent UTIs, and other symptoms of genitourinary syndrome of menopause. I share a powerful story of a patient with breast cancer history who was denied hormone therapy by her oncology team, only to have them completely reverse course once the boxed warning was removed.The conversation covers the most frequently asked questions from listeners: Is it perimenopause or just stress? (It's both.) Why is my libido gone? (Biology, psychology, and life circumstances all play a role.) Why do I keep getting UTIs after sex? (Often it's vestibulodynia or changes in the vaginal microbiome from estrogen deficiency.) How do I talk to my partner about sex? (Communication is key, and sometimes you need a sex therapist to help.)We also discuss the reality of midlife weight gain, the role of GLP-1 medications like Wegovy and Zepbound, and why building muscle matters more than endless cardio. This episode is a celebration of how far we've come and a reminder that you don't have to suffer through menopause.Highlights:The FDA removed the boxed warning from vaginal estrogen—what this means for access to careThe biology behind midlife low libido and why it's not "all in your head"Why recurrent UTIs after sex might actually be vestibulodynia or vaginal microbiome changes.How to talk to your partner about sex when you've never had those conversationsThe truth about midlife weight gain and what hormones can and can't doGLP-1 medications: FDA approvals for weight loss, cardiovascular protection, MASH, and sleep apneaThank you for being here for 100 episodes. Honestly, there have been times I've wanted to stop, but then I get a DM from someone saying they heard something on the podcast that changed their care, or a patient tells me they finally found answers here. That's what keeps me going.The biggest way you can help me keep doing this work is simple: share this show with someone who needs it and hit subscribe. When you share an episode with a friend who's struggling, a family member who's been dismissed by doctors, or post about it on social media, you're helping me reach more women who deserve better care.Thank you for listening, for learning, and for advocating alongside me. Here's to the next 100.Get in Touch with Me: WebsiteInstagramYoutubeSubstack
Chris Cuomo responds directly to a flood of viewer comments and questions — from accusations that he's “changed,” to criticism of his Alan Dershowitz interview, to claims that he's too hard or too soft on Trump. He addresses confusion around shutdown politics, breaks down the realities of the ACA debate, and pushes back on misinformation about what Trump did or didn't do — including his shifting claim about “ending seven wars.” Cuomo also explains why outrage remains the dominant political currency online, and why so many people mistake anger for clarity. Cuomo digs into arguments about wealth, privilege, and independence; clarifies his views on Epstein, Venezuela, and selective outrage; and calls out how social media's algorithmic incentives twist honest disagreement into hostility. He talks openly about intensity, decency, and why provocation has replaced persuasion — and closes with a reminder not to waste moments with family on fights that don't matter. Follow and subscribe to The Chris Cuomo Project on Apple Podcasts, Spotify, and YouTube for new episodes every Tuesday and Thursday: https://linktr.ee/cuomoproject Join Chris Ad-Free On Substack: http://thechriscuomoproject.substack.com Support our sponsors: Exclusive $45-off Carver Mat at https://on.auraframes.com/CUOMO Promo Code CUOMO Ready to give Rugiet a try? Get 15% off your first order by going to http://rugiet.com/CUOMO and using code CUOMO. Disclaimer - Rugiet prescriptions are compounded medications, available only if prescribed following an online consultation with a licensed clinician. Compounded drugs can be prescribed by federal law, but are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness, or manufacturing. Individual results may vary. Full safety information available at Rugiet.com. Don't miss NOBL's biggest Sale of the Year! Head to http://NOBLTravel.com for up to 62% off your entire order! #NOBL #ad Learn more about your ad choices. Visit podcastchoices.com/adchoices
Marty Makary explains how the FDA began after toxic chemicals in food caused deaths, how it grew to regulate 20 percent of the US economy, and what he has changed in his first eight months including removing artificial dyes, cutting red tape, adding AI, and rewriting the food pyramid.
Around the country, a pervasive question being asked: How can I afford my prescription drugs? The high cost of those medications, particularly very expensive drugs to treat serious diseases like multiple sclerosis and cystic fibrosis, have fueled a nationwide business in which insurance programs are using companies called “alternative funding programs” or AFPs that promise to get these medications at little or no cost to the patient. “RiskyRX,” a CNBC investigation, found AFPs are becoming more pervasive around the country as drug costs skyrocket.CNBC submitted nearly 100 public records requests and sorted through more than 10,000 pages of contracts, emails, invoices and complaints that show these companies have penetrated the country's health-care system through private employers, cities, counties, school districts and unions. In some cases, employers require their staff to use an AFP. CNBC traced the trail of medications from abroad to the U.S. via a supply chain that's not authorized by the pharmaceutical companies that manufacture the medications. The investigation features an exclusive interview with a Department Of Homeland Security official who says these programs should be shut down because they're illegal and post a serious safety risk to patients. A former high-ranking FDA official, speaking out for the first time, says these programs typically don't disclose the risks to patients. The AFPs strongly defend their business practices as both legal and safe and say their businesses are an antidote to high prescription drug prices. Those prices, across all drugs, in the U.S. are nearly three times as much, on average, as those in other high-income countries, according to a 2024 report by Rand, a nonprofit, nonpartisan research organization. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Thanksgiving and overindulgenceA food poisoning incidentObservations on health at ThanksgivingWhat do you think of online sites offering prescriptions for hair loss via a questionnaire?
My granddaughter suffers from menstrual cramps. Do you have any suggestions?Do you recommend nicotinamide daily to prevent recurrence of basal cell cancers?What works best to lower fibrinogen?I've been on Ozempic for a year and have diarrhea every morning!Is bypass surgery still being done?Would you recommend Bergamot for fatty liver?
Feeling alone in a crowded room is a hallmark of today's loneliness epidemic, proving that company alone isn't the answer. Healing loneliness starts by looking inward rather than outward. By cultivating self-love, you nurture the most important relationship of all—the one with yourself—which naturally leads to genuine contentment and stronger bonds with the people around you. To explore the deep-rooted aspects of the loneliness epidemic, Harvesting Happiness Podcast Host Lisa Cypers Kamen speaks with bestselling author, relationship expert, and co-creator of the powerful Inner Bonding® self-healing process, Dr. Margaret Paul. Margaret discusses how her 6-step Inner Bonding process leads to healing the soul and creates deeper bonds with ourselves and within our closest relationships. This episode is proudly sponsored by: Signos — Offers the world's first FDA-cleared AI-driven app and CGM for weight management and wellness that turns data into lasting habits for better health. Visit https://signos.com/ and use promo code HHTR to get $10 off select plans. Like what you're hearing? WANT MORE SOUND IDEAS FOR DEEPER THINKING? Check out More Mental Fitness by Harvesting Happiness bonus content available exclusively on https://harvestinghappiness.substack.com/ and https://medium.com/@HarvestingHappiness.
Did you know the FDA just reversed 23 years of misinformation about hormone therapy? In this powerful episode, I'm breaking down what this landmark ruling means for every woman, and why an entire generation was robbed of the opportunity to protect their health. This is vindication, but it also opens up critical questions about what comes next and how you can take control of your hormone health today. I'm sharing the complete roadmap to natural hormone balancing and bioidentical hormone replacement, including what your doctor isn't telling you about testing, metabolism, and the real foundations that make hormones work. You'll Discover: ● Why the FDA's recent ruling is a game-changer (and what it means for your health decisions!) ● The truth about menopause: it's not a disease, but leaving it untreated accelerates aging ● How estrogen affects every organ system in your body (except two cells!) and why losing it impacts more than just reproduction ● Why "test, don't guess" is essential, and why timing matters for perimenopausal women ● The critical difference between bound and free hormones, and why urinary testing reveals what blood work can't ● The five foundational pillars that make or break your hormone health: nutrition, sleep optimization, stress management, strategic exercise, and toxin reduction ● Why putting hormones in a "dumpster fire" lifestyle won't work (and how to create the right environment for them to thrive!) ● How liver detoxification and hormone metabolism determine whether you'll feel great or symptomatic on HRT ● The specific exercise prescription for menopause: strength training, zone 2 cardio, and why over-exercising can backfire Ready to Take Control of Your Hormone Health? This transition requires new strategies and support, and you have more control than you think. Watch the full episode now, and share this with every woman who needs to know she has options!
The long-awaited revision of ISO 10993-1 is almost here – and the MedTech community is full of questions.Will we need to retest everything?Is this a complete game-changer, or just an evolution?How will Notified Bodies and the FDA react?In this episode of the Medical Device Made Easy Podcast, Monir El Azzouzi hosts Marina Daineko, biocompatibility consultant at Intrinsic Medical Group, to unpack what's really coming.This episode covers:The background and current status of the ISO 10993-1 revisionWhy the new version is best seen as an evolution, not a revolutionHow the standard pushes further into a risk-based, scientifically justified approachThe link with ISO 14971 and lifecycle thinkingChanges in contact categorization and cumulative exposureThe industry trend toward reducing animal testing through in vitro methods and data-driven justificationHow to conduct a gap analysis once the new standard is publishedPractical advice on how to prioritize updates without freezing projects or panickingReal-world examples where process chemicals, not base materials, changed the risk pictureHow Intrinsic Medical Group supports companies with biological evaluation, cleanliness, sterilization and reusable devices
Send us a textIn this episode I sit down with Dr. Melissa Miskell, a gynecologist with 30 years of experience who has helped thousands of women feel like themselves again using bioidentical hormone therapy. If you're over 40 and dealing with brain fog, mood swings, belly fat, hot flashes, low sleep, or low libido and keep being told “that's just aging” ,this one is for you.Dr. Miskell explains, in simple language, what really happens in perimenopause and menopause, why so many women are misdiagnosed with depression or anxiety, and how hormones like estrogen, progesterone and testosterone actually protect your heart, bones and brain. We also talk about the famous Women's Health Initiative study, what it got wrong, and why the FDA has now removed the black box warning from estrogen.You'll hear:The key differences between “normal aging” and hormone imbalanceWhy so many women are given 3 medications (antidepressant, anxiety, sleep) when what they really need is hormone testingWhat bioidentical hormones are and how they're different from older synthetic optionsWhich labs women over 40 should ask for (and why symptoms matter more than one number on a lab sheet)When HRT makes sense, when it doesn't, and how fast many women start to feel betterIf you've ever felt dismissed, unheard, or confused about your symptoms, this episode will give you hope and better questions to ask your doctor.Check out Dr Miskell websites https://feelbetterfromdayone.com/ and her clinic https://hormonesbydesign.comIf you want help with strength training, habits, and building a balanced lifestyle alongside your hormone journey, check out my coaching options https://www.personaltrainerturo.com/Thank you for listening!
Send us a textSchedule an Rx AssessmentSubscribe to Master The MarginWhat does it really take to start and sustain a successful compounding pharmacy in 2026? In this episode, Scotty Sykes, CPA, CFP®, and Austin Murray sit down with Amy Summers, PharmD, BCSCP and of Restore Health Consulting, to discuss how pharmacy owners can move from idea to implementation when entering the compounding space.We cover:Designing a purpose-built facility for USP standards and your product mixThe mindset shift from dispensing to creating and how to balance quality with patient careMarket analysis, relationships, and niche focus in building a sustainable businessKey trends driving growth, consolidation, and private investment in the compounding industryMore About Our Guest:Amy Summers, PharmD, BCSCP is an independent consultant, specializing in business, operations, quality assurance, and regulatory compliance matters for the pharmaceutical compounding industry. She earned her PharmD degree from the University of California San Francisco and was among the first pharmacists in the nation to earn a Board Certified Sterile Compounding Pharmacist (BCSCP) credential. Dr. Summers has spent her entire career as a pharmacist in various settings centered around non-sterile and sterile compounding. She has formerly served as Director of Operations and Pharmacist in Charge at organizations engaged in compounding and also as Managing Director of a FDA-registered 503B outsourcing facility. With extensive experience in USP standards, accreditation, cGMP, and regulatory compliance, Dr. Summers has also served as an expert witness for matters related to compounding.Stay connected with Amy and Restore Health Consulting: Amy Summers LinkedInRestore Health Consulting WebsiteRestore Health Consulting LinkedInStay connected with us on social media:Facebook: https://www.facebook.com/sykesandcoTwitter: https://twitter.com/OllinSykesLinkedIn: https://www.linkedin.com/company/sykes-&-company-p-a-?trk=tyahScotty Sykes – CPA, CFP® LinkedIn: https://www.linkedin.com/in/scottysykes/More on this topic:Podcast: The Trusted Pharmacist: Advocacy and Building a Resilient PharmacyPodcast: From Counter to Capitol
On this week's episode, Ali sits down with an icon and pioneer in the infertility community: double-board certified REI and infertility warrior Dr. Natalie Crawford. Natalie opens up about her four pregnancy losses before having her two kiddos, being both sides of the stirrups as doctor and patient, and what it's really like to navigate infertility as someone who “knows too much.” She talks about bucking the system when it came to social media; co-founding her boutique clinic in Austin, TX, Fora Fertility (and why she decided to start her own thing); and her new book, The Fertility Formula. Natalie also talks about how to advocate for yourself in the exam room, how her patients inspired parts of the book; and what she wants every fertility patient to hear right now.For more, and to preorder The Fertility Formula, go to www.nataliecrawfordmd.comIG: @nataliecrawfordmdEPISODE SPONSORS: THE WORK OF ART BOOK SERIESAli's Children's Book Series about IVF, IUI and Family Building Through Assisted Reproductive Technology https://www.infertileafgroup.com/booksThe latest book in the Work of ART series, “You Are a Work of ART," is for every kiddo born through ART -- and the people who love them.Order "Work of ART," "Beautiful Bird" and "You Are a Work of ART," now at https://www.infertileafgroup.com/booksFERTILITY RALLYIG: @fertilityrallywww.fertilityrally.comNo one should go through infertility alone. Join the Worst Club with the Best Members at fertilityrally.com. We offer 5 to 6 support groups per week, three private Facebook groups, tons of curated IRL and virtual events, and an entire community of more than 500 women available to support you, no matter where you are in your journey.Join today at link in bio on IG @fertilityrally or at www.fertilityrally.com/membershipPHERDALIG: pherdal_sciencePherDal is the world's first and only FDA-cleared, sterile, at-home insemination kit designed to help people build their families in the comfort of home. Created by parents who've been there, PherDal is safe, simple, and affordable—putting more options in your hands as you grow your family. Explore at PherDal.com.Support this podcast at — https://redcircle.com/infertile-af-infertility-and-modern-family-building-through-art/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
This week, I'm joined by Josh Kilmer-Purcell and Dr. Brent Ridge, founders of Beekman 1802, to share how they built a nationally loved skincare brand rooted in kindness and authentic connection. They open up about starting their business during a recession with nothing but grit, determination, and a whole lot of heart—proving you can build something great even in the hardest seasons. We dive into what real success looks like when you define it for yourself and align every decision with your personal values. Josh and Brent also remind us that everyday wisdom is often more powerful than any formal credentials when it comes to building something meaningful. You'll walk away with practical insights on leading with kindness, building authentic relationships, and staying grounded no matter where your journey begins.In this episode:How kindness became the foundation of their businessEarly struggles of starting a business during a recessionSharing wisdom and prioritizing collaboration over competitionBuilding authentic, “neighborly” relationships with customers and the communityThe difference between kindness and niceness in businessMeasuring success by impact on people, not just salesThe role of communication and authenticity in building a strong businessHere is my favorite quote from this episode:"We are in the people business. We're not in the product business." - Kim GravelExperience Bible Life Guides: Forgiven and Free — a 21-day Bible-based journey to emotional freedom, available free at https://try.biblelifeguides.com/products/forgiven-free-with-kim-gravelTake the Quiz: Which Maribelle and the Manger character are you? Find out here: https://bit.ly/4pxUqF8If you want your questions answered then leave a comment or call me and leave me a voicemail at 404-913-6460There is BONUS CONTENT in our free newsletter so make sure to subscribe at https://www.kimgravelshow.comNEW! Order Kim's Holiday Children's BookEmbark on a magical adventure with five friends as they journey together to witness the birth of Jesus! It's a heartwarming holiday tale your whole family will love.Kim's brand-new storybook Maribelle and the Manger is available now: https://maribelleandthemanger.com/?utm_source=lwya.beehiiv.com&utm_medium=newsletter&utm_campaign=pre-order-kim-s-new-book&_bhlid=075a4287c5257cbe2d43cc23e857262cc9cf39cdConnect with Josh Kilmer-Purcell and Dr. Brent Ridge:WebsiteInstagramFacebookTikTokYouTubeG.O.A.T. Wisdom: How to Build a Truly Great Business--From the Founders of Beekman 1802Connect with Me:YouTubeFacebookInstagramTikTok WebsiteNew episodes of The Kim Gravel Show drop every Wednesday at 6pm EST.Support our show by supporting our Sponsors:Aura FramesThe holidays are almost here, and Aura Frames is the gift that brings memories to life. Aura is a digital photo frame with unlimited storage that can be updated instantly from any phone, anywhere. It's an easy way to share moments, keep traditions alive, and feel connected every day. You can't wrap togetherness, but you can frame it.For a limited time, visit https://on.auraframes.com/KIM and get $45 off Aura's best-selling Carver Mat frame with promo code KIM at checkout. This exclusive Black Friday/Cyber Monday offer is their best of the year—order before it ends!HERSMenopause can bring hot flashes, fatigue, brain fog, and other challenging symptoms—but getting help doesn't have to be hard. HERS now offers menopause care through their trusted online health platform. Complete a simple medical intake, and if eligible, a licensed provider creates a personalized treatment plan with access to FDA-approved options. Many women start feeling relief in 4–6 weeks, with better sleep, fewer hot flashes, and improved overall well-being.Visit https://www.forhers.com/kim to get a personalized plan. Not available in all 50 states. Perimenopause & Menopause by Hers includes hormonal health support, educational resources, digital tools, and prescription options, if appropriate. See website for full details, important safety information, and restrictions.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
On this episode of Vitality Radio, Jared breaks down a stunning new investigation showing just how many supplements sold on Amazon failed to meet label claims—some containing zero active compounds! You'll learn why these quality issues keep happening, how to protect yourself as a consumer, and what to look for when shopping during Black Friday weekend.Jared also gives a clear, ingredient-by-ingredient look at Get Well Stay Well, the immune formula he created 20 years ago and Vitality's top winter seller. He explains how the herbs, nutrients, and mushrooms support the body's natural defenses and why the flexible “stay well” and “get well” dosing makes it so versatile.Finally, you'll get a preview of the biggest Black Friday / Small Business Saturday sale Vitality has ever offered, including rare discounts on major brands and a special free-product bonus with qualifying purchases.Products:Get Well, Stay WellVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
We are back with lots of OncoPharm updates: 1. The belantamab mafodotin REMS program details are available....and it's a lot. How will belantamab mafodin-regimens be used with the upcoming MAJESTIC-3 data of teclistamab-daratumumab? 2. The capecitabine label is updated and calls for pre-treatment DPYD testing 3. Daratumumab gets an FDA approval for high-risk smoldering myeloma based on the AQUILA study Critique of AQUILA: https://doi.org/10.1093/oncolo/oyaf216 4. A pertuzumab biosimilar (Poherdy) is approved 5. Epcoritamab nets regular approval and a new indication with lenalidomide/rituximab (RR) for Follicular Lymphoma 6. Ziftomenib, a new menin inhibitor, is approved for NPM1 relapsed/refractory AML 7. Sevabertinib, a new HER2 inhibiting TKI, is approved for ERBB2 mutated NSCLC, with evidence of activity in patients previously treated with HER2-antibody-drug conjugates 8. Expected FDA approvals for durvalumab + FLOT in preoperative gastric/GEJ cancer; neoadjuvant pembrolizumb + enforumab vedotin in bladder cancer (non-cisplatin eligible), and tarlatamab regular approval for small cell lung cancer 9. Happy Thanksgiving!
In this episode of The Oncology Brothers, we dived into the pivotal study of MATTERHORN, which explored the addition of Durvalumab to perioperative FLOT chemotherapy for patients with resectable gastric and gastroesophageal junction adenocarcinoma. Join us as we welcome Dr. Yelena Y. Janjigian, a medical oncologist from Memorial Sloan Kettering and the lead author of the MATTERHORN study. Dr. Janjigian shared insights on the study's design, findings, and the implications for clinical practice, including: • The significance of the study in the context of recent FDA approvals and treatment advancements. • Key survival data, including a three-year overall survival rate of 68.6% with Durvalumab. • The feasibility of combining immunotherapy with chemotherapy and impact on surgical outcomes. • Management of side effects and clinical pearls for practitioners. We also discussed the potential for extrapolating this data to esophageal adenocarcinoma and the role of PD-L1 status in treatment decisions. Whether you're a seasoned oncologist or just starting in the field, this episode is packed with valuable information to help you provide the best care for your patients. Follow us on social media: • X/Twitter: https://twitter.com/oncbrothers • Instagram: https://www.instagram.com/oncbrothers • Website: https://oncbrothers.com/ Don't forget to like, share, and subscribe for more practice-changing updates in oncology! #MATTERHORN #GastricCancer #Immunotherapy #Durvalumab #OncologyBrothers #GIOncology
This episode is part of Dr. Taniqua Miller's Menopause Potpourri Series — a collection of bite-size, evidence-based conversations on the most talked-about topics in midlife health.In this installment of Midlife Revival, Dr. Taniqua breaks down the buzz around hormone pellet therapy — one of the most popular (and misunderstood) treatments in menopause care.If you've ever asked, “Should I get pellets?” this episode gives you the clarity you need.Dr. T explains:What estrogen and testosterone pellets actually are — and how they workWhy pellets aren't FDA-approved and what that means for safetyPotential side effects when hormone levels overshootThe real cost of pellets (including those hidden lab fees)Whether you've tried pellets or you're just curious, you'll walk away empowered to make informed decisions — without the fear, confusion, or hype.
Dystrophinopathies are heritable muscle disorders caused by pathogenic variants in the DMD gene, leading to progressive muscle breakdown, proximal weakness, cardiomyopathy, and respiratory failure. Diagnosis and management are evolving areas of neuromuscular neurology. In this episode, Kait Nevel, MD, speaks with Divya Jayaraman, MD, PhD, an author of the article "Dystrophinopathies" in the Continuum® October 2025 Muscle and Neuromuscular Junction Disorders issue. Dr. Nevel is a Continuum® Audio interviewer and a neurologist and neuro-oncologist at Indiana University School of Medicine in Indianapolis, Indiana. Dr. Jayaraman is an assistant professor of neurology and pediatrics in the division of child neurology at the Columbia University Irving Medical Center in New York, New York. Additional Resources Read the article: Dystrophinopathies Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @IUneurodocmom Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Nevel: Hello, this is Dr Kate Nevel. Today I'm interviewing Dr Divya Jayaraman about her article on dystrophinopathies, which she wrote with Dr Partha Ghosh. This article appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Divya, welcome to the podcast, and please introduce yourself to the audience. Dr Jayaraman: Thank you so much, Dr Nevel. My name is Divya, and I am an assistant professor of Neurology and Pediatrics at Columbia University Irving Medical Center, and also an attending physician in the Pediatric Neuromuscular program there. In that capacity, I see patients with pediatric neuromuscular disorders and also some general pediatric neurology patients and also do research, primarily clinical research and clinical trials on pediatric neuromuscular disorders. Dr Nevel: Wonderful. Thank you for sharing that background with us. To set us on the same page for our discussion, before we get into some more details of the article, perhaps, could you start with some definitions? What comprises the dystrophinopathies? What are some of the core features? Dr Jayaraman: So, the dystrophinopathies, I like that term because it is a smaller subset from the muscular dystrophies. The dystrophinopathies are a spectrum of clinical phenotypes that are all associated with mutations in the DMD gene on chromosome X. So, that includes DMD---or, Duchenne muscular dystrophy---, Becker muscular dystrophy, intermediate muscular dystrophy (which falls in between the two), dilated cardiomyopathy, asymptomatic hyperCKemia, and manifesting female carriers. In terms of the core features of these conditions, so, there's some variability, weakness being prominent in Duchenne and also Becker. The asymptomatic hyperCKemia, on the other hand, may have minimal symptoms and might be found incidentally by just having a high CK on their labs. They all will have some degree of elevated CK. The dilated cardiomyopathy patients, and also the Becker patients to a lesser degree, will have cardiac involvement out of proportion to skeletal muscle involvement, and then the manifesting carriers likewise can have elevated CK and prominent cardiac involvement as well as some milder weakness. Dr Nevel: Now that we have some definitions, for the practicing neurologists out there, what do you think is the most important takeaway from your article about the dystrophinopathies? Dr Jayaraman: I like this question because it suggests that there's something that, really, any neurologist could do to help us pick up these patients sooner. And the big takeaway I want everyone to get from this is to check the CK, or creatine kinase, level. It's a simple, cheap, easy test that anyone can order, and it really helps us a lot in terms of setting the patient on the diagnostic odyssey. And in terms of whom you should be thinking about checking a CK in, obviously patients who present with some of the classic clinical features of Duchenne muscular dystrophy. This would include young boys who have toe walking, as they're presenting, sign; or motor delayed, delayed walking. They may have calf hypertrophy, which is what we say nowadays. You might have seen calf pseudohypertrophy in your neurology textbooks, but we just say calf hypertrophy now. Or patients can often have a Gowers sign or Gowers maneuver, which is named after a person called Gowers who described this phenomenon where the child will basically turn over and use their hands on the floor to stand up, usually with a wide-based gait, and then they'll sort of march their hands up their legs. That's the sort of classic Gowers maneuver. There are modified versions of that as well. So, if anyone presents with this classic presentation, for sure the best first step is to check a CK. But I would also think about checking a CK for some atypical cases. For example, any boy with any kind of motor or speech delay for whom you might not necessarily be thinking about a muscle disorder, it's always good practice to check a CK. Even a boy with autism for whom you may not get a good clinical exam. This patient might present to a general pediatric neurology clinic. I always check a CK in those patients, and you'll pick up a lot of cases that way. For the adult folks in particular, the adult neurologist, a female patient could show up in your clinic with asymptomatic hyperCKemia. And I think it's an important differential to think about for them because this could have implications not just for their own cardiac risks, but also for their family planning. Dr Nevel: So, tell us a little bit more about the timing of diagnosis. Biggest takeaway: check a CK if this is anywhere on your radar, even if somewhat of an atypical case. Why is it so important to get kiddos started on that diagnostic odyssey, as you called it, early? Dr Jayaraman: This is especially important for kids because if they especially get a Duchenne muscular dystrophy diagnosis, you might be making them eligible for treatments that we've had for some time, and also treatments that were not available earlier that hinge on making that diagnosis. So, for example, people may be skeptical about steroids, but there's population data to suggest that initiation and implementation of steroids could delay the onset of loss of ambulation as much as three years. So, you don't want to deprive patients of the chance to get that. And then all the newer emerging therapies---which we'll be talking about later, I'm sure---require a Duchenne muscular dystrophy diagnosis. So, that's why it's so important to check a CK, have this on your radar, and then get them to a good specialist. Dr Nevel: I know that you alluded already, or shared a few of the kind of exam paroles or findings among patients with dystrophinopathy. But could you share with us a little bit more how you approach these patients in the clinic who are presenting with muscle weakness, perhaps? And how do you approach this or think about this in terms of ways to potentially differentiate between a dystrophinopathy versus another cause of motor weakness or delay? Dr Jayaraman: It's helpful to think through the neuraxis and what kinds of disorders can present along that neuraxis. A major differential that I'm always thinking about when I'm seeing a child with proximal weakness is spinal muscular atrophy, which is a genetic anterior horn cell disorder that can also present in this age group. And some of the key differences there would be things like reflexes. So, you should have dropped reflexes in spinal muscular atrophy. In DMD, surprisingly, they might have preserved Achilles reflexes even if their patellar reflexes are lost. It may only be much later that they go on to lose their Achilles reflex. So, if you can get an Achilles reflex, that's quite reassuring, and if you cannot, then you need to be thinking about spinal muscular atrophy. They can both have low muscle tone and can present quite similarly, including with proximal weakness, and can even have neck flexion weakness. So, this is an important distinction to make. The reason for that is, obviously there are treatments for both conditions, but for spinal muscular atrophy, timing is very, very important. Time is motor neurons, so the sooner you make that diagnosis the better. Other considerations would be the congenital muscular dystrophies. So, for those that they tend to present a lot younger, like in infancy or very early on, and they can have much, much higher CKS in that age range than a comparable Duchenne or Becker muscular dystrophy patient. They can also have other involvement of the central nervous system that you wouldn't see in the dystrophinopathies, for example. My mnemonic for the congenital muscular dystrophies is muscle-eye-brain disease, which is one of the subtypes. So, you think about muscle involvement, eye involvement, and brain involvement. So, they need an ophthalmology valve. They can have brain malformations, which you typically don't see in the dystrophinopathies. I think those are some of the major considerations that I have. Obviously, it's always good to think about the rest of the neuraxis as well. Like, could this be a central nervous system process? Do they have upper motor neuron signs? But that's just using all of your exam tools as a neurologist. Dr Nevel: Yeah, absolutely. So, let's say you have a patient in clinic and you suspect they may have a dystrophinopathy. What is your next diagnostic step after your exam? Maybe you have an elevated CK and you've met with the patient. What comes next? Dr Jayaraman: Great question. So, after the CK, my next step is to go to genetics. And this is a bit of a change in practice over time. In the past we would go from the CK to the muscle biopsy before genetic testing was standard. And I think now, especially in kids, we want to try and spare them invasive procedures where possible. So, genetic testing would be the next step. There are a few no-charge, sponsored testing programs for the dystrophinopathies and also for some of the differential diagnosis that I mentioned. And I think we'll be including links to websites for all of these in the final version of the published article. So, those are a good starting point for a genetic workup. It's really important to know that, you know, deletions and duplications are a very common type of mutation in the DMD gene. And so, if you just do a very broad testing, like whole exome, you might miss some of those duplications and deletions. And it's important to include both checking for duplications and deletions, and also making sure that the DMD gene is sequenced. So always look at whatever genetic test you're ordering and making sure that it's actually going to do what you want it to do. After genetics, I think that the sort of natural question is, what if things are not clear after the genetics for some reason? We still use biopsy in this day and age, but we save it for those cases where it's not entirely clear or maybe the phenotype is a little bit discordant from the genotype. So, for mutations that disrupt the reading frame, those tend to cause Duchenne muscular dystrophy, whereas mutations that preserve the reading frame tend to cause Becker muscular dystrophy. There are some important exceptions to this, which is where muscle biopsy can be especially helpful in sorting it out. So, for example, there are some early mutations early in the DMD gene where, basically, they find an alternate start codon or an initiation codon to continue with transcription and translation. So, you end up forming a largely functional, somewhat truncated protein that gives you more of a milder Becker phenotype. On the other hand, you can have some non-frameshift or inframe mutations that preserve the reading frame, but because they disrupt a very key domain in the protein that's really crucial for its function, you can actually end up with a much more severe Duchennelike phenotype. So, for these sorts of cases, you might know a priori you're dealing with them, but might just be a child who is who you think has DMD has a mutation that's showed up on testing. There isn't enough in the literature to point you one way or another, but they look maybe a little milder than you would expect. That would be a good kid to do a biopsy in because there are treatment decisions that hinge on this. There are treatments that are only for Duchenne that someone with a milder phenotype would not be eligible for. Dr Nevel: So, that kind of stepwise approach, but maybe not all kids need a muscle biopsy is what I'm hearing from you. If it's a mutation that's been well-described in the literature to be fitting with Duchenne, for example. Dr Jayaraman: Absolutely. Dr Nevel: So, after you confirm the diagnosis through genetic testing---and let's say, you know, whether or not you do a muscle biopsy or not, after you know the diagnosis is a dystrophinopathy---how do you counsel the families and your patients? What are the most important points to relay to families, especially in that initial phase where the diagnosis is being made? Dr Jayaraman: This is a lot of what we do in pediatric neurology in general, right? So, I actually picked up this approach from the pediatric hematology oncology specialists at Boston Children's. They had this concept of a day-zero conversation, which is the day that you disclose the life-changing diagnosis or potentially, at some point, terminal diagnosis to a family. And some of the key components of that are a not beating around the bush, telling them what the diagnosis is, and then letting them have whatever emotional response they're going to have in the moment. And you may not get much further than that, but honestly, you want them to take away, this is what my child has. I did not do anything to cause this, nor could I have done anything to prevent this. Because often for these genetic conditions, there's a lot of guilt, a lot of parental guilt. So, you want to try and assuage that as much as possible. And then to know that they're not going to be alone on this journey; that, you know, they don't have to have it all figured out right then, but we can always come back and answer any questions they have. There's going to be a whole team of specialists. We're going to help the family and the kid manage this condition. Those are sort of my big takeaways that I want them to get. Dr Nevel: Right. And that segues into my next question, which is, who is part of that team? I know that these teams that help take care of people with dystrophinopathies and other muscle disorders can be very large teams that span multiple specialists. Can you talk a little bit more about that for this group of patients? Dr Jayaraman: Of course. So, the neuromuscular neurologist, really, our role is in coordinating the diagnosis, the initiation of any disease-specific treatments, and coordinating care with a whole group of specialists. So, we're sort of at the center of that, but everyone else is equally important. So, the other specialists include physical therapists; occupational therapists; rehab doctors or physiatrists; orthotists who help with all of the many braces and other devices that they might need, wheelchairs; pulmonology, of course, for managing the respiratory manifestations of this. It becomes increasingly important over time, and they are involved early on to help monitor for impending respiratory problems. Cardiac manifestations, this is huge and something that you should be thinking about even for your female carriers, the mother of the patient you're seeing in the clinic, or your patient who comes to adult clinic with asymptomatic hyperCKemia. if you end up making a diagnosis of DMD carrier for those patients, or if you make a Becker diagnosis, the cardiac surveillance is even more important because the cardiac involvement can be out of proportion to the skeletal muscle weakness. And of course, extremely important for the Duchenne patients as well. Endocrinologists are hugely important because in the course of treating patients with steroids, we end up giving them a lot of iatrogenic endocrinologic complications. Like they might have delayed puberty, they might have loss of growth, of height; and of course metabolic syndrome. So, endocrinology is hugely important. They're also important in managing things like fracture prevention, osteoporosis, prescribing bisphosphonates if necessary. Nutrition and GI are also important, not just later on when they might need assistance to take in nutrition, whether that's through tube feeds, but also earlier on when we're trying to manage the weight. Orthopedics, of course, for the various orthopedic complications that patients develop. And then finally, a word must be said for social work and behavioral and mental health specialists, because a lot of this patient population has a lot of mental health challenges as well. Dr Nevel: After you give the diagnosis, you've counseled the patient and families and you've had those kind of initial phase discussions, the day-zero discussion, when you start getting into discussions or thoughts about management, disease-specific medication. But what are the main categories of the treatment options, and maybe how do you kind of approach deciding between treatment options for your patients? Dr Jayaraman: So, there are two broad categories that I like to think about. So, one is the oral corticosteroids and oral histone deacetylase, or HDAC inhibitors, which share the common characteristic that they are non-mutation specific. And within corticosteroids, patients now have a choice between just Prednisone or Prednisolone, or Deflazacort or Vermilion. The oral HDAC inhibitors are newly FDA-approved as a nonsteroidal therapy in addition to corticosteroids in DMD patients above six years of age. I would say we're in the early phase of adoption of this in clinical practice. And then the other big category of treatment options would be the genetic therapies as a broad bucket, and this would include gene therapy or gene replacement therapy, of which the most famous is the microdystrophin gene therapy that was FDA-approved first on an accelerated approval basis for ages four to eight, and then a full approval in that age group as well as an accelerated approval for all comers, essentially, with DMD. This is obviously controversial. Different centers approach this a bit differently. I think our practice at our site has been to focus on the ambulatory population, just thinking about risk versus benefit, because the risks are not insignificant. So really this is something that should be done by experienced sites that have the bandwidth and the wherewithal to counsel patients through all of this and to manage complications as they arise with regular monitoring. And then another class that falls within this broader category would be the Exon-skipping therapies. So as the name suggests, they are oligonucleotides that cause an Exon to be skipped. The idea is, if there is a mutation in a particular Exon that causes a frame shift, and there's an adjacent Exon that you can force skipping of, then the resulting protein, when you splice the two ends together, will actually allow restoration of the reading frame. I think the picture I want to paint is that there's a wide range of options that we present to families, not all of which everyone will be eligible for. And they all have different risk profiles. And I really think the choice of a particular therapy has to be a risk-benefit decision and a shared decision-making process between the physician and the family. Dr Nevel: What is going on in research in this area? And what do you think will be the next big breakthrough? I know before we started the recording you had mentioned that there's a lot of things going on that are exciting. And so, I'm looking forward to hearing more. Dr Jayaraman: Of course. So, I'll be as quick as I can with this. But I mentioned that next-generation Exon skipping therapies, I think the hope is that they will be better at delivering the Exon skipping to the target tissue and cells and that they might be more efficacious. I'm also excited about next-generation gene therapies that might target muscle more specifically and hopefully reduce the off-target effects, or combination use of gene therapies with other immunosuppressive regimens to improve the safety profile and maybe someday allow redosing, which we cannot do currently. Or potentially targeting the satellite cells, which are the muscle stem cells, again, to improve the long term durability of these genetic therapies. Dr Nevel: That's great, thank you for sharing. Thank you so much for talking to me today about your article. I really enjoyed learning more about the dystrophinopathies. Today I've been interviewing Dr Divya Jayaraman about her article on the dystrophinopathies, which she wrote with Dr Partha Ghosh. This article appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Please be sure to check out the Continuum Audio episodes from this and other issues. Also, please read the Continuum articles for more details than what we were able to get to today during our discussion. Thank you, as always, so much to the listeners for joining us today, and thank you, Divya, for sharing all of your knowledge with us today. Dr Jayaraman: Thank you so much for having me on the podcast. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.
In this episode, Cameron sits down with Steven Huang, the Director of Finance, People, IT, and Community at MAPS, the Multidisciplinary Association for Psychedelic Studies. Steven helps lead global efforts to bring psychedelic research, policy reform, and public understanding into the mainstream, building on MAPS' 40-year history at the forefront of mental health innovation.Steven shares his unlikely path from life insurance actuary to Silicon Valley analyst to psychedelic industry operator, including how psychedelics shaped his career decisions, his leadership growth, and his move into the second-in-command role during a major organizational crisis. He and Cameron explore what the government is getting right, where the psychedelic movement is headed, and how MAPS balances scientific rigor with visionary cultural work.If you've been watching psychedelics move from taboo to the TED stage to boardrooms and leadership circles, this conversation gives a rare inside look at the movement from someone steering the ship.Timestamped Highlights00:00 Steven opens with a core leadership lesson around self-belief.01:28 Cameron introduces Steven and MAPS' mission.03:00 Cameron's first encounter with Rick Doblin and the psychedelic space.04:09 What MAPS is and how it's shaped the psychedelic movement.05:18 How cannabis legalization opened the door for psychedelic conversations.07:23 Steven on public stigma shifting and psychedelics entering mainstream business culture.09:00 Understanding MDMA therapy, ketamine, and where research is now.11:41 Cameron's personal experiences with psychedelic therapy.12:44 How government perception and bipartisan interest are evolving.14:45 How MAPS is funded and why conferences aren't profit centers.15:39 The path from MAPS to Lycos and Resilient Pharmaceuticals.18:00 Real-world use: psilocybin dispensaries and psychedelic churches.20:19 Where psychedelics help… and where clinical caution still matters.22:20 The role of intention in therapeutic and recreational use.24:32 Steven's psychedelic-inspired career pivot from actuary to Facebook.27:21 Cameron's first MDMA experience and how it changed his worldview.29:05 When company culture goes too far.30:30 The challenge of leading a nonprofit in a regulated landscape.33:16 The FDA setback and massive internal shift at MAPS.37:04 Steven's first encounter with Rick Doblin and the reality of working with a visionary founder.39:00 Steven's advice to his younger self.Resources & MentionsMDMA-assisted therapyKetamine therapyPsilocybinAyahuascaPsychedelic Science ConferenceResilient Pharmaceuticals (formerly Lykos Therapeutics)Rick DoblinAbout the GuestSteven Huang is the Director of Finance, People, IT, and Community at MAPS, the Multidisciplinary Association for Psychedelic Studies. With a background spanning actuarial science, Facebook's people analytics team, and diversity leadership roles across Silicon Valley, Steven brings a rare mix of analytical rigor and human-centered...
Citizen groups are forming as the system continues to break and yet the OPP is busy busting Mohawk weed and Tobacco growers We get Esoteric - ET doesn't care about us, Egyptian looking beings at Holloman AFB, Earth was never ours - 2026 the files come out, missing hikers, ancient past, WTF happened in 1913, the Baltic Sea Anomaly update, the X Banker who backs out pre sacrifice ritual, Giants and The Book of Enoch, the FDA protocol for negative entity attachment, the cancellation of the Aether, Project Looking Glass... And then more serious, Autopilot trackers track Congress and stocks, Will Trump really go after anyone funding violence, the Grizzly attacking kids in BC, human hunting, and what ever happened to that study about kids in the classroom under fluorescent lighting To gain access to the second half of show and our Plus feed for audio and podcast please clink the link http://www.grimericaoutlawed.ca/support. For second half of video (when applicable and audio) go to our Substack and Subscribe. https://grimericaoutlawed.substack.com/ or to our Locals https://grimericaoutlawed.locals.com/ or Rokfin www.Rokfin.com/Grimerica Patreon https://www.patreon.com/grimericaoutlawed Support the show directly: https://grimericacbd.com/ CBD / THC Tinctures and Gummies https://grimerica.ca/support-2/ Eh-List Podcast and site: https://eh-list.ca/ Eh-List YouTube: https://www.youtube.com/@TheEh-List Our Adultbrain Audiobook Podcast and Website: www.adultbrain.ca Our Audiobook Youtube Channel: https://www.youtube.com/@adultbrainaudiobookpublishing/videos Darren's book www.acanadianshame.ca Check out our next trip/conference/meetup - Contact at the Cabin www.contactatthecabin.com Other affiliated shows: www.grimerica.ca The OG Grimerica Show www.Rokfin.com/Grimerica Our channel on free speech Rokfin Join the chat / hangout with a bunch of fellow Grimericans Https://t.me.grimerica grimerica.ca/chats Discord Leave a review on iTunes and/or Stitcher: https://itunes.apple.com/ca/podcast/grimerica-outlawed http://www.stitcher.com/podcast/grimerica-outlawed Sign up for our newsletter http://www.grimerica.ca/news SPAM Graham = and send him your synchronicities, feedback, strange experiences and psychedelic trip reports!! graham@grimerica.com InstaGRAM https://www.instagram.com/the_grimerica_show_podcast/ Purchase swag, with partial proceeds donated to the show www.grimerica.ca/swag Send us a postcard or letter http://www.grimerica.ca/contact/ ART - Napolean Duheme's site http://www.lostbreadcomic.com/ MUSIC Tru Northperception, Felix's Site sirfelix.bandcamp.com Links to the stuff we chatted about: https://nakedemperor.substack.com/p/have-rich-murder-tourists-been-paying?utm_source=post-email-title&publication_id=602373&post_id=178877843&utm_campaign=email-post-title&isFreemail=true&r=24pqe&triedRedirect=true&utm_medium=email https://x.com/401_da_sarpanch/status/1990538811894534394?s=20 https://x.com/DominionSoc/status/1990412199110602786?s=20 https://x.com/wealthmoose/status/1990140709991489603?s=20 https://x.com/HighPeaks77/status/1993061627139104911?s=20 https://x.com/buperac/status/1992296128025653486?s=20 https://x.com/brandilwells/status/1992306794375401686?s=20 https://x.com/Tablesalt13/status/1991908533135388855?s=20 https://x.com/Chrisjjosephs/status/1991202966225973668?s=20 https://x.com/OMApproach/status/1991220792982663580?s=20 https://www.turkiyetoday.com/region/bulgarian-man-who-went-missing-17-years-ago-found-alive-in-pirin-national-park-3209381#:~:text=A%20Bulgarian%20man%20who%20went,of%20the%20park's%20camping%20areas. https://x.com/newstart_2024/status/1991999231373230464?s=43 https://x.com/therealinspired/status/1991186395151384719?s=43 https://x.com/returnofkappy/status/1990480198601744836?s=43 https://www.facebook.com/reel/2239248879822560 https://www.facebook.com/reel/1215500003724311 https://www.facebook.com/reel/1891390198442191 https://x.com/rjnol/status/1989925913031573842?s=43 https://x.com/uapreportingcnt/status/1990190976451686649?s=43 https://x.com/occultni/status/1988248832279294341?s=43 https://x.com/uapwatchers/status/1989790604130197828?s=43 https://x.com/karma44921039/status/1992892642070262027?s=43 https://x.com/conspiracyb0t/status/1992869169684160864?s=43 https://x.com/lifelibertylisa/status/1990140074185330942?s=43 https://x.com/clif_high/status/1990792652070023375?s=43 https://x.com/DonaldBestCA/status/1989878780987318304?s=20 https://x.com/DerWulf/status/1989879653394518193?s=20 https://x.com/goofbusterss/status/1989831059710906476?s=20 https://x.com/MatrixMysteries/status/1989387351643308188?s=20 https://x.com/JimFergusonUK/status/1989242174974689717?s=20 https://x.com/covertress/status/1987571431668908537?s=20 https://x.com/covertress/status/1987571431668908537?s=20
This podcast is brought to you by Outcomes Rocket, your exclusive healthcare marketing agency. Learn how to accelerate your growth by going to outcomesrocket.com Remote therapeutic monitoring only works when it strengthens the relationship between patient and provider rather than adding friction. In this episode, Steven Coen, CEO and co-founder of SaRA Health, shares how his own frustrations as a physical therapy patient inspired him to redesign MSK care between visits. He describes how SaRA's one-character SMS check-ins reduce cognitive load, strengthen continuity, and significantly boost adherence and outcomes. Steven also explains how remote therapeutic monitoring codes reshaped their business model, leading them to build an internal RCM system and prepare for 2026 codes that could greatly increase practice revenue. He highlights what sets their FDA-designated software apart, the lack of remote strategies across most practices, and the broader payment and prior-auth challenges shaping hybrid care models. Tune in and learn how remote care, thoughtful design, and better business models are reshaping MSK patient engagement! Resources Connect with and follow Steven Coen on LinkedIn. Follow SaRA Health on LinkedIn and discover their website.Email Steven directly here.
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SPONSOR: BRUNT WORKWEAR - When you’re on your feet all day, the wrong boots can ruin everything — Which is why BRUNT Workwear stands out. Their boots are built tough, but comfortable. No stiff leather, no painful break in period, they feel ready for a full shift on day one. BRUNT was created by someone who actually worked in the trades, who knew the big legacy brands weren’t listening anymore. If you’re shopping for someone who works hard, these are the gifts they’ll actually use. BRUNT is releasing limited-edition styles all month long — once they sell out, they’re gone — and they’ve got everything from heavy - duty pants to incredibly comfortable hoodies built to take a beating. Best of all, there’s zero risk. If they’re not a fit, BRUNT will take them back. With temps dropping and holidays coming up, it’s time to treat yourself or the hard-working man in your life to real comfort. Skip the throwaway gifts and get him something built to last: Brunt workwear. Our listeners get $10 off their entire order with code “RICK” at checkout. That’s https://www.BRUNTWORKWEAR.COM , and use code “RICK”. Order today and let them know you heard it here on the show! - https://www.BRUNTWORKWEAR.COM SPONSOR: RELIEFBAND - Nausea can wreck your entire day. Reliefband is the device that actually stops it. It’s FDA-cleared, clinically proven, totally drug-free, and non-drowsy. It works by sending gentle pulses to the wrist that calm the nerves in your stomach, and you can adjust the intensity depending on how you feel.There are two versions. The Reliefband Sport is sleek, rechargeable, and water-resistant. The Reliefband Flex is lighter, great for daily wear, and uses a swappable battery so you’re never caught without power. What makes Reliefband so useful is how quickly it works. If you’ve been waiting to try Reliefband, this is the time! The Black Friday and Cyber Monday deals run through the end of November, and you can save up to 30% sitewide! Reliefband’s Sport and Flex models make amazing gifts for anyone who deals with nausea, and with the extended return window through January 1, you can shop early and stress-free. Reliefband is also FSA and HAS eligible, so it’s a great way to use those end-of-year dollars on something that really works. Go to https://www.Reliefband.com to shop the Black Friday and Cyber Monday sale, and save up to 30% off sitewide. -- https://www.Reliefband.comSPONSOR: BLAZETV -- BlazeTV doesn’t exist without people like you, who genuinely care about preserving honest conversation in this country. You’ve seen what’s happening on the right: the gatekeeping, the approved narratives, the pressure for everyone to fall in line. That’s not who we are. We’re not bound to talking points or beholden to anyone’s agenda. We don’t have to check our convictions with a corporate sponsor before we speak. We show up with one thing: the freedom to tell the truth as we see it. And that freedom only exists because of BlazeTV subscribers. Once a year, we lower the barrier for people who want to be part of this movement, people who refuse to sit on the sidelines. Right now, for Black Friday only, you can get $40 off a BlazeTV annual subscription. If you’ve been on the fence, this is the moment. Not because of a discount, but because your subscription actually keeps independent voices alive, voices that aren’t controlled by Big Tech, advertisers, or political gatekeepers. You make it possible for us to keep fighting, creating, and telling the truth without compromise. If you believe America is still worth fighting for, this is your moment to join the fight. And if you’re already a subscriber, THANK YOU. You make all of this possible. to someone who needs a space free from filtered, “approved” opinions.Thank you so much for watching and continuing to support the movement that we’re building together. Go to https://www.BlazeTV.com/RICK and use code BLACKFRIDAY40 to grab our Black Friday savings while it’s still here. That’s https://www.BlazeTV.com/RICK , code BLACKFRIDAY40. -- https://www.BlazeTV.com/RICKSee omnystudio.com/listener for privacy information.
Stop this barbaric treatment! Sign the petition here: https://stopect.com/email-congress This barbaric medical treatment is still being used to treat depression and mental illness in the US. Find out about the dangerous side effects of electroconvulsive therapy (ECT), one of the most controversial mental health treatments that exists. You won't believe they're still doing this!0:00 Introduction: ECT for depression0:41 Electroshock treatment background2:11 Is ECT dangerous? 2:23 What is electroconvulsive therapy?4:22 More side effects of electroconvulsive therapy4:38 Trauma from electroshock therapy This barbaric mental health therapy costs around $2000 to $2500 per treatment, and is covered by Medicaid, Medicare, and the VA system. It's a multibillion-dollar market! The average treatment plan includes 12 sessions in the first month, followed by maintenance sessions every 3 weeks. This treatment has never been scientifically proven to work! There have been no official trials, and it has even been performed on children and pregnant women. The UN calls this treatment a human rights abuse and compares this forced treatment on minors to torture. In China, it's actually used as a form of torture. In addition, this treatment has never been FDA-approved and was merely grandfathered in. In 2018, the FDA downgraded it from a high-risk classification to a moderate-risk classification. This dangerous treatment causes structural brain damage, creates swelling and inflammation in the brain, and even kills brain cells. Electroconvulsive therapy involves putting 150 volts through a person's brain to induce a grand mal seizure. ECT treatment comes with many side effects, has 60 documented adverse events, and can cause permanent brain damage, memory loss, and heart attacks. This treatment uses enough energy to stop the heart, and there is nothing stopping the voltage from traveling to the rest of the body. This can lead to cardiac arrest! People who use this treatment are also at an increased risk of suicide. I've seen firsthand in practice that people who've had this treatment lose their personality, humor, creativity, and more. ECT treatment can lead to death, destruction of cells and mitochondria, and shrinking of the hippocampus. Neurologist Dr. John Feinberg noted in 1977 that ECT caused structural brain damage, indistinguishable from head trauma. If you have depression, diet and lifestyle changes may help. Increasing vitamin D levels, B-vitamin levels, and omega-3 levels, along with a low-carb diet and intermittent fasting, can significantly improve your symptoms.Dr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the Director of Dr. Berg Nutritionals and author of the best-selling book The Healthy Keto Plan. He no longer practices, but focuses on health education through social media.Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.
After decades of stagnation and caution, the FDA is radically changing their advice on hormone replacement therapy for menopausal women. We speak to the FDA Commissioner about the new advice for women. Get the facts first with Morning Wire. Chevron: Build a brighter future right here at home. Visit https://Chevron.com/America to discover more. HelloFresh: Go to https://HelloFresh.com/MORNINGWIRE10FM now to Get 10 Free Meals + a Free Item for Life! - - - Wake up with new Morning Wire merch: https://bit.ly/4lIubt3 - - -Privacy Policy: https://www.dailywire.com/privacy Learn more about your ad choices. Visit podcastchoices.com/adchoices
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