Reaction which occurs within an organism for the purpose of defending against a pathogen
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Gut Health for Women: Why Fatigue, Bloating, and Mood Swings Might Start in Your Gut Are you feeling fatigued, moody, bloated—or just not quite yourself lately? You're not alone. And it might be your gut trying to get your attention. In this episode of The Natalie Tysdal Podcast, I open up about a deeply personal health crisis that became a turning point in my wellness journey (don't judge me for crying!). As a health journalist with over 30 years of experience interviewing doctors and wellness experts, I've learned that gut health plays a much bigger role in our energy, hormones, immunity, and mood than most of us realize—especially as women. What You'll Learn in This Episode: The four essential things every woman needs to know about gut health How hidden gut issues can show up as fatigue, anxiety, poor sleep, hormone imbalance, and more Early warning signs your gut is out of balance—and what to do before it becomes a crisis My step-by-step strategies for gut healing, including nutrition, supplements, and lifestyle shifts One simple thing you can do this week to start resetting your gut health
In this episode of 'Conversations in Lung Cancer Research,' Professor Tom John from the Peter MacCallum Cancer Centre in Melbourne discusses the significant progress and excitement surrounding cancer vaccines, particularly their emerging role in lung cancer treatment.He is joined by Professor Ken O'Byrne, a medical oncologist and clinical scientist at the Princess Alexandra Hospital and Queensland University of Technology, and Professor Georgina Long AO, the medical director of the Melanoma Institute of Australia and co-recipient of the 2024 Australian of the Year.The experts delve into technological advances spurred by COVID-19 vaccine development, promising results from recent melanoma and lung cancer vaccine trials, and the potential for personalised neoantigen mRNA vaccines. They also discuss historical challenges in vaccine efficacy and the promising future of immunotherapy and cancer vaccines, including patient perspectives and the logistics of rapid vaccine production and distribution.00:00 Introduction03:15 Historical Context of Cancer Vaccines05:13 Technological Advances in Vaccine Development06:53 The Promise of mRNA Technology14:03 Personalised vs. Off-the-Shelf Vaccines18:02 Identifying Neoantigens for Vaccines21:13 Caution and Optimism in Vaccine Development23:18 Exploring Tumour Mutation Burden and Vaccine Bias29:35 Challenges and Opportunities in Metastatic Disease33:53 Immunotherapy and Vaccine Hesitancy37:52 Future of Cancer Vaccines and Rapid Innovation42:14 Conclusion and Final Thoughts
In this episode of the Ducks Unlimited Podcast, we're joined by Dr. RuthAnn Lobos of Purina. We dive deep into puppy health, discussing essential vaccines, building immunity, the science behind proper nutrition, and why it all matters for your duck dog. Plus, Dr. Lobos shares valuable socialization tips to help your puppy grow into a confident hunting companion.Listen now: www.ducks.org/DUPodcastSend feedback: DUPodcast@ducks.org
Livestock vaccines must be stored and handled correctly in order to trigger an immune response against detrimental organisms.
A Gluten Free PodcastEpisode 176On today's episode I chat with Associate Professor Dr Bob Anderson — a world-renowned gastroenterologist, immunologist and trailblazer in coeliac disease research. From his foundational work at the Walter and Eliza Hall Institute (WEHI) to creating Nexvax2, leading Novoviah Pharmaceuticals, and becoming President of the International Society for the Study of Coeliac Disease (ISSCD), Bob has shaped the coeliac research landscape as we know it.We discuss how his career began, what he's most excited about in current research, and what's ahead for coeliac disease globally — including a look at ICDS 2026 in Melbourne.What We Cover
EP 206: In this quick and dirty, I'm diving straight into one of the most controversial things I've said recently - and trust me, it stirred up some serious heat on a recent social media post. After appearing on Codie Sanchez's podcast and dropping a bomb about how certain chronic diseases might actually be contagious (yeah, you read that right), the internet went wild. I'm breaking down why I stand by it, what the data shows, and how our microbiomes, social circles, and even online interactions might be influencing our health way more than we thought. On This Episode We Cover: 00:00:00 – Introduction 00:03:43 – Can Microbiomes Be Contagious? 00:04:44 – What Drives Chronic Disease Risk 00:06:40 – How Proximity Impacts Your Health 00:08:29 – Root Causes of Chronic Illness 00:09:57 – Why This Matters for Public Policy 00:13:49 – Rethinking the Hygiene Hypothesis 00:16:21 – The Danger of Microbiome Loss 00:17:17 – Your Inner Circle Affects Your Health Show Links: Dr Tyna on Codie Sanchez Are Noncommunicable Diseases Communicable? The Hygiene Hypothesis, The Covid Pandemic, And Consequences For The Human Microbiome Impact Of Obesity On Influenza A Virus Pathogenesis, Immune Response, And Evolution Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains Transfer Of Gut Microbiota From Lean And Obese Mice To Antibiotic-Treated Mice Further Listening: EP. 172: GLP-1 Agonists and the Gut Microbiome: Unveiling Their Role in Metabolic Health | Solo Sponsored By: Puori | Go to Puori.com/drtyna and use code DRTYNA to get 20% off LVLUP | Head over to LVLUPHealth.com and use code DRTYNA at checkout to get 20% off your order sitewide. Timeline | Timeline is offering 10% off your order of Mitopure Go to timeline.com/drtyna. Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
Commentary by Dr. Jian'an Wang.
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Connect with Dr. Bhanote Website (https://www.drbhanote.com/) Show Highlights: Importance of pathology in diagnosing health implications related to breast implants Experiences and practices in oncologic reconstruction and tissue sample examination Immune response to foreign bodies, particularly silicone from breast implants Chronic inflammation and its effects on health and diagnosis Risks associated with breast implants including infections and rare cancers like ALCL The significance of comprehensive patient medical history in treatment and diagnosis Cellular changes and responses to implants, including the formation of fibrous tissue The role of detoxification in promoting overall health and managing symptoms Challenges in imaging and diagnosing issues in patients with implants A need for patient education and awareness regarding the risks and benefits of cosmetic procedures Bio: Dr. Bhanote Dr. Monisha Bhanote, MD, FCAP, ABOIM, is a bestselling author of The Anatomy of Wellbeing and a distinguished authority in plant-based gut health, cellular health, and longevity. With quintuple medical board certifications, she leads in integrative medicine, functional culinary medicine, cytopathology, and anatomic/clinical pathology. As the founder of WELLKULÅ, she merges ancient wisdom with mind-body science to forge a transformative path toward optimal health and longevity. Dr. Bhanote is a graduate of NYU Winthrop University Hospital, Cornell, and the Andrew Weil Center for Integrative Medicine. She is featured in Shape, Reader's Digest, and Martha Stewart Living and shares her insights globally through DrBhanote.com. Serving on various clinical advisory boards, her profound interest in the nexus of nutrition and the microbiome, cellular health, and mindfulness practices underscores her commitment to revolutionizing wellbeing. She empowers individuals with sustainable, science-backed lifestyle changes that highlight the role of cellular health and nutrition in extending healthspan and vitality. Links and Resources Let's Connect Podcast: https://podcasts.apple.com/gb/podcast/breast-implant-illness/id1678143554 Spotify: https://open.spotify.com/show/1SPDripbluZKYsC0rwrBdb?si=23ea2cd9f6734667 TikTok: https://www.tiktok.com/@drrobertwhitfield?t=8oQyjO25X5i&r=1 IG: https://www.instagram.com/breastimplantillnessexpert/ FB: https://www.facebook.com/DrRobertWhitfield Linkedin: https://www.linkedin.com/in/dr-robert-whitfield-md-50775b10/ X: https://x.com/rob_whitfieldmd Read this article - https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness Shop: https://drrobssolutions.com SHARP: https://www.harp.health NVISN Labs - https://nvisnlabs.com/ Get access to Dr. Rob's Favorite Products below: Danger Coffee - Use our link for mold free coffee - https://dangercoffee.com/pages/mold-free-coffee?ref=ztvhyjg JASPR Air Purifier - Use code DRROB for the Jaspr Air Purifier - https://jaspr.co/ Echo Water - Get high quality water with our code DRROB10 - https://echowater.com/ BallancerPro - Use code DRROBVIP for the world's leader in lymphatic drainage technology - https://ballancerpro.com Ultrahuman - Use code WHITFIELD10 for the most accurate wearable - https://www.ultrahuman.com/ring/buy/us/?affiliateCode=drwhitfield
Dr. Sharon Bergquist is an award-winning physician, innovative healthcare leader, and visionary researcher, renowned for spearheading a science-based approach to applying lifestyle as medicine. She is the author of "The Stress Paradox: Why You Need Stress to Live Longer, Healthier, and Happier." She discusses the misunderstood role of stress, emphasizing its potential benefits when managed and utilized correctly. Dr. Bergquist explains how stress can enhance cellular function, boost resilience, and improve overall health. She delves into topics such as the physiology of stress, the science of hormesis, and the benefits of controlled stressors including plant toxins, thermal exposure, fasting, exercise, and psychological challenges. The discussion underscores the importance of balancing stress and recovery to promote cellular repair and long-term well-being.
Dr. Hoffman continues his conversation with Dr. Sharon Bergquist, author of "The Stress Paradox: Why You Need Stress to Live Longer, Healthier, and Happier."
Welcome back to the Information Entropy Podcast where today we are taking you on a wild and chaotic episode of Swamps! Yes, the wetlands that are smelly and gross… much like the opening half of the episode. Mitch takes us on a journey exploring the immune response to food poisoning to shed light on his week and it is fascinating as well as horrifying. Back on track the boys explore what differentiates swamps from other wetland habitats, how important they are for carbon sequestration, and the Surinam Toad… but if you have trypophobia don't listen to that bit! Music: HOME - AWAY
Dr. Hoffman continues his conversation with Nate Jones, CEO of Xlear, Inc., about his extraordinary win against the FTC for health freedom.
In this special episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman interviews Nathan Jones, CEO and founder of Xlear, Inc., about the extraordinary legal battle Xlear faced against the Federal Trade Commission (FTC) for making scientific claims about their xylitol-based products. Despite submitting numerous studies to substantiate their claims, the FTC pursued the case, which began in 2020 during the COVID-19 pandemic. Jones shares the journey and significant personal and financial costs involved, ultimately leading to the FTC dropping the case. The episode explores the broader implications for the natural products industry and highlights the importance of continued advocacy for scientific truth and free speech.
Dr. Hoffman continues his conversation with Kat James, renowned nutrition and inside-out transformation pioneer.
Transformation expert Kat James provides a deep-dive into the intricacies of the microbiome and its extensive impact on various aspects of health. Kat James, bestselling author of 'The Truth About Beauty,' shares her personal journey of overcoming eating disorders and metabolic imbalances through gut health. The discussion covers the roles of probiotics, prebiotics, and postbiotics in fostering a healthy microbiome, along with the unexpected connections between gut health and muscle mass, bone strength, mental health, and even skin health. They also touch upon practical tips for maintaining a balanced microbiome, especially during travel, and emphasize the innovative use of Dr. Ohhira's Probiotics. With emerging studies and expert insights, this episode sheds light on how optimizing gut health can lead to transformative well-being.
In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman welcome Dr. Margot Savoy to discuss the changing landscape of vaccine recommendations. The scientists explore risk-based vaccination approaches, focusing particularly on RSV and pneumococcal vaccines, while examining how factors like age and immunosenescence influence vaccine effectiveness. Dr. Savoy provides insights into how pandemic experiences have shaped vaccine strategies and emphasizes the importance of personalized vaccination discussions between healthcare providers and patients. The conversation offers listeners valuable understanding of current vaccine recommendations and their public health implications. All our sources from this episode are available at: https://www.unbiasedscipod.com/episodes/ (00:00) Intro (02:37) Understanding Risk-Based Vaccine Recommendations (06:47) Safety vs. Efficacy in Vaccines (08:56) Dynamic Nature of Vaccine Recommendations (12:50) Types of Vaccine Recommendations (20:11) Impact of Recommendations on Insurance Coverage (22:13) Recent Changes in RSV Recommendations (22:43) Understanding RSV and Its Impact (29:01) Immunosenescence: Aging and Immune Response (34:32) Pneumococcal Disease and Vaccination Recommendations (42:08) Final Thoughts: The Future of Vaccination: Innovations and Conversations Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices
Send us a textMom of two (including one who experienced a vaccine injury), toxicologist, and creator of the *must read*, comprehensive Vaccine Guide drops some jaw-dropping bombshells that will make you think twice about the safety, efficacy, ethics, and necessity of these routine shots.We talk about the tragic human sacrifices who were callously exploited for the sake of growing viruses in aborted fetal cells. The ingredients in vaccines will make your stomach churn— and no, we're not just talking about the well-known and widely discussed neurotoxic aluminum.We also discuss the superiority of natural immunity verses artificial immunity via vaccination and the longterm benefit of allowing our bodies to encounter sickness in the wild without synthetic interference. Specifically, we learn about which cancers you are at a lesser risk of having as a result of acquiring natural immunity from certain "vaccine preventable" illnesses.You'll hear us talk about the role breastmilk antibodies play from the start of life as well as the importance of honoring the divine order of growth from a spiritual standpoint.Despite the benefits we acknowledge that homeopathy provides, we talk about why we are against homeoprophylaxis as a “safer” alternative to vaccines. We also learn why vitamin D supplementation is not only pointless but also to some degree harmful.This conversation is sure to make your head spin in the best way!Follow Ashley on instagram @insta_ashleyeverlyAshley's websiteAccess Ashley's free vaccine guideSupport the showJOIN OUR NEW, PRIVATE COMMUNITY! DONATE (Thank you!!
In an effort to bring on great guests to go beyond the narrow realm of fitness and nutrition, Dr Joe Zundell (PhD in Cancer Biology) joins me to talk about: -How strength training reduces cancer risk -How maintaining muscle and bone helps survive cancer treatment -Why the cancer cure suppression conspiracy theory is silly logic -What lifestyle behaviours contribute the greatest risk of developing cancer -The relationship between cancer and obesity -Why there's no one dietary ideology that helps to defeat cancer -and much more 00:15 Meet Dr. Joe Zundell 01:12 Strength Training and Cancer Risk 03:19 Understanding Cachexia 07:42 Cancer Treatment and Quality of Life 09:28 Cancer Complexity and Misconceptions 19:51 Environmental and Lifestyle Factors 26:00 Diet, Obesity, and Cancer Risk 32:03 The Impact of Western Diet on Liver Cancer 33:39 Dietary Advice for Cancer Patients 35:57 Understanding Autophagy and Its Role in Cancer 39:30 The Balance of Immune Response in Cancer Treatment 41:17 Debunking Myths About Cancer and Diet 48:51 The Role of Natural Remedies in Cancer Treatment 51:14 Conclusion and Final Thoughts I've been putting a lot of time and effort into making these new episodes valuable for you. You can help me get these great guests and their knowledge in front of more people by: -Subscribing and checking out more episodes -Sharing on your social media (please tag me - I promise I'll respond) -Sharing with the friend you think of who needs this episode Follow Andrew Coates: Instagram: @andrewcoatesfitness Join My Email List: www.andrewcoatesfitness.com
Women who believe their implants are making them sick report a wide range of symptoms including extreme fatigue, muscle and joint pain, headache, brain fog, hair loss, rashes, dry mouth and eyes, depression, anxiety, and insomnia. These conditions appear within a few months to several years following surgery and seem to follow a secondary surgery like revision or exchange. However, the exact cause is difficult to pin down because other conditions, like Lyme disease and toxic mold exposure, can cause similar symptoms. Using PCR testing (instead of traditional CLIA-based lab testing), Dr. Rob discovered that over 60% of the breast implants he removed all had one thing in common. Dr. Robert Whitfield describes his methodology for identifying this complicated, misunderstood condition and shares his treatment strategies utilizing nutrition and genetic testing to put his patients on the path to healing. For more healing resources created by Dr. Rob, visit our store - Dr. Rob's Solutions at https://drrobssolutions.myshopify.com (https://drrobssolutions.myshopify.com). Show Highlights: Causes of BII (00:03:56) Biofilm and its significant contribution to breast implant illness cases What is Biofilm? (00:04:56) Explanation of biofilm as a bacterial or fungal contaminant affecting health and inflammation Environmental Factors (00:05:26) Environmental exposures, like mold and Lyme disease, and their role in BII symptoms Gut Health and Immune Response (00:07:43) Gut health's impact on immune function and overall wellness in BII patients Identifying Symptoms and Providers (00:10:12) How to identify symptoms and seek appropriate medical guidance for BII Explant Surgery Options (00:10:12) Overview of surgical options available for patients considering explant surgery Symptom Abatement Timeline (00:11:20) Discussion on the expected timeline for symptom improvement after explant surgery Pathology and Testing (00:12:36) Importance of laboratory analysis in evaluating post-surgery health and contamination Nutritional Support and Genetic Testing (00:13:50) The role of nutrition and genetic predisposition testing in managing BII Cautions on Online Medical Advice (00:15:13) Warnings against seeking medical advice from unqualified sources online Links and Resources Let's Connect... Podcast: https://podcasts.apple.com/gb/podcast/breast-implant-illness/id1678143554 Spotify: https://open.spotify.com/show/1SPDripbluZKYsC0rwrBdb?si=23ea2cd9f6734667 TikTok: https://www.tiktok.com/@drrobertwhitfield?t=8oQyjO25X5i&r=1 IG: https://www.instagram.com/breastimplantillnessexpert/ FB: https://www.facebook.com/DrRobertWhitfield Linkedin: https://www.linkedin.com/in/dr-robert-whitfield-md-50775b10/ X: https://x.com/rob_whitfieldmd Read this article - https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness Shop: https://drrobssolutions.com SHARP: https://www.harp.health NVISN Labs - https://nvisnlabs.com/ Get access to Dr. Rob's Favorite Products below: Danger Coffee - Use our link for mold free coffee - https://dangercoffee.com/pages/mold-free-coffee?ref=ztvhyjg JASPR Air Purifier - Use code DRROB for the Jaspr Air Purifier - https://jaspr.co/ Echo Water - Get high quality water with our code DRROB10 - https://echowater.com/ BallancerPro - Use code DRROBVIP for the world's leader in lymphatic drainage technology - https://ballancerpro.com Ultrahuman - Use code WHITFIELD10 for the most accurate wearable - https://www.ultrahuman.com/ring/buy/us/?affiliateCode=drwhitfield
In this episode of Curiosity Killed the Plaque, Spring Hatfield, RDH, BSPH, discusses immune response and the implications on oral health. Like this show? Leave us a review on your favorite podcasting app! Need CE? Start earning CE credits today at https://rdh.tv/ce Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/ Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/ Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh/
Researchers from the Texas A&M College of Veterinary Medicine and Biomedical Sciences are closer to developing an oral vaccine for anthrax as demonstrated in a study published earlier this year in the Journal of Zoo and Wildlife medicine. Joining me to discuss this development is Chase Nunez, MS PhD, Jamie Benn, PhD, AWB and Walter Cook, Phd, DVM. To watch the video version- go to Outbreak News TV
What is actually occurring within a sheep with worm resistance? This week on the podcast we have a fascinating discussion with Dr Kelsey Bentley who has spent her career so far looking into the immune mechanisms of Katahdin sheep in the US. Kelsey runs us through what happens biologically within the sheep to make it ‘resistant'. She has also researched the importance of the role of colostrum in lamb immunity. Kelsey explains how it provides essential immunological benefits - particularly through IgG and IgA antibodies - and that colostrum quality varies between sheep and therefore is under genetic influence. Highlights:- The make-up of the Katahdin breed- The biology of parasite resistance- The genetics of parasite resistance- The effect of worm resistance on other traits like growth- The importance of good quality colostrum - Behavioral responses to illnessesHead Shepherd is brought to you by neXtgen Agri International Limited. We help livestock farmers get the most out of the genetics they farm with. Get in touch with us if you would like to hear more about how we can help you do what you do best: info@nextgenagri.com.Thanks to our sponsors at MSD Animal Health and Allflex, and Heiniger Australia and New Zealand. Please consider them when making product choices, as they are instrumental in enabling us to bring you this podcast each week.Check out Heiniger's product range HERECheck out the MSD range HERECheck out Allflex products HERE
For quite some time now, ever since entering the world of red light therapy — but particularly when getting into the realm of methylene blue — I've wondered what nitric oxide's true impact on our body and wellness is. For the vast majority of my life, I was under the belief that all nitric oxide = good. That was ingrained at an early age with the countless pre-workout supplements I was taking during my heavy lifting days during high school through college. But it didn't stop there. The message of nitric oxide = good and that "more is better" has been perpetuated in the wellness, and even longevity, industries by countless experts and influencers.But how is that possible if one of methylene blue's main actions is nitric oxide inhibition? How is that possible if nitric oxide is a free radical and an environmental pollutant and, thus, is effectively an "electron stealer"?For whatever reason, I have never been able to get a straight answer from anyone on this topic. But serendipitously, I was recently reading a book that provided the most clearcut and sensible explanation that would allow for nitric oxide to be both "good" and "bad". The book is Methylene Blue: Magic Bullet: The Ultimate Mitochondrial Support, by Dr. John Lieurance. As I learned from the book, it turns out that nitric oxide is quite similar to how inflammation can be both a positive and a negative for our physiology; but with some additional nuances through in there. Today's episode is about nitric oxide and the roles it plays in our wellness and what the best strategies are for best harnessing the "good" nitric oxide while downregulating the "bad" nitric oxide. If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Book referenced in episode: Methylene Blue: Magic Bullet: The Ultimate Mitochondrial Support - Key Points: [00:00] Introduction to Red Light Therapy and Anti-Aging [00:13] Mitochondrial Triad and Dr. Mike Belkowski [00:36] Seasonal Stress and Immune Support [01:59] Introduction to Nitric Oxide [02:38] Understanding Nitric Oxide and Redox Signaling [04:05] Dr. John Lawrence and Nitric Oxide Types [06:32] Types of Nitric Oxide Synthases (NOS) [10:25] Methylene Blue and INOS Inhibition [11:19] Nitric Oxide in Fitness and Erectile Dysfunction [14:06] Risks of High Nitric Oxide and Cardiovascular Disease [16:10] Cytokine Storm and Immune Response [17:39] Red Light Therapy's Interaction with Nitric Oxide [18:40] Nitric Oxide Boosters: Pros and Cons [20:29] Dr. Jason Sommers and the Role of Red Light Therapy, Methylene Blue, HBOT [23:06] Caution in Medical Recommendations [23:42] Case Study on Methylene Blue and SSRIs [24:47] FDA and Health Canada Standpoints [26:09] Psychedelics and Methylene Blue Synergy [27:02] Standard Dosages vs. Surgical Dosages [29:19] Recap on Safety of Methylene Blue with SSRIs [29:34] Returning to Nitric Oxide [31:23] Introduction to Nitric Oxide (NO) [32:58] Three Types of Nitric Oxide [34:49] Balancing Nitric Oxide Types [38:13] Benefits of ‘Press and Pulse' Activation [39:40] Methylene Blue's Role in INOS Inhibition [40:52] Red Light Therapy Benefits for ENOS [41:17] Hyperbaric Oxygen Therapy and NOS [42:02] Summary on Nitric Oxide's Health Impact [43:04] Chronic Inflammation and INOS [43:46] Optimal Nitric Oxide Ratios for Health [44:13] Exploring Other Modalities for NOS Regulation [45:02] Conclusion and Call to Action - Save 20% when you purchase via The Mitochondrial Triad Bundle!Choose any one RLT device + one BioBlue supplement + one BioC60 supplement = save 20% on the entire order! No discount code necessary, click here to order! - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn BioLight: Website Instagram YouTube Facebook
Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune memory diversity in human upper airway (Nature) How Plasmodium infection promotes B cell cancers (Cell) Time stamps by Jolene. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Bats use proteins to offensively fight disease, keeping these creatures of the night healthy.
Emily Watkins - Researcher & Technical Instructor at the University of Brighton The conversation explores the value of academia in the first responder community and the consequences of chronic high exposure firefighting. The discussion focuses on the research conducted by Emily Watkins, a senior lecturer at the University of Roehampton, on the health and wellbeing of firefighters. The conversation delves into the challenges of funding research in this field and the reluctance to address the long-term implications of occupational exposure. The World Health Organization's declaration on firefighting as a carcinogenic occupation is also discussed, along with the need for evidence-backed preventative measures. The study conducted by Watkins examines the inflammatory and immune responses of breathing and operating instructors (BAIs) in the firefighting profession. The findings suggest that BAIs may experience chronic inflammation due to their high frequency of exposures. The study also explores the physiological and psychological effects of firefighting workloads on BAIs and firefighters. The conversation covered various topics related to the health and well-being of firefighters, including mood states, fatigue, biomarkers, cardiovascular disease, and the World Health Organization's research on firefighter health. The discussion highlighted the need for comprehensive testing and screening for firefighters, as well as the importance of self-care and early support. The conversation also touched on the challenges faced by female firefighters and the need for research and support specific to their unique physiological differences.You can connect with Emily at - Emily.Watkins@roehampton.ac.ukWe only feature the latest 200 episodes of the podcast on public platforms so to access our podcast LIBRARY, every Debrief & document CLICK HEREPODCAST GIFT - Get your FREE subscription to essential Firefighting publications HERE A big thanks to our partners for supporting this episode.GORE-TEX Professional ClothingMSA The Safety CompanyPATROL STORE UKIDEXHAIX FootwearGRENADERIP INTO Podcast ApparelLyfe Linez - Get Functional Hydration FUEL for FIREFIGHTERS, Clean no sugar for daily hydration. 80% of people live dehydrated and for firefighters this costHibern8 - a plant based sleep aid specially designed to promote a restful night's sleep and awaken you feeling refreshed and energisedPlease support the podcast and its future by clicking HERE and joining our Patreon Crew
View Powerpoint Slides: Understanding your Lymphatic SystemAre you unknowingly neglecting a crucial part of your body's defense system?Dr. Katie Deming welcomes Lymphatic expert Desiree De Spong who reveals simple, daily practices that can boost your body's natural healing abilities and help prevent complications like lymphedema.Discover the secrets of the lymphatic system and how it can transform your health, especially after breast surgery or during cancer recovery. Desiree shares easy-to-understand explanations of how this complex system works and why it matters for everyone, not just those recovering from illness or surgery.Chapters:05:17 - Lymph nodes: Pathogen managers and immunity agents14:58 - Retraining body: Balance lymphatic, enhance relaxation26:43 - Right bra fit - freedom, movement, relief36:14 - Daily drainage routine45:43 - Yoga pose: relaxation, energy boost, thyroid aidDiscover practical tips you can start using today to improve your lymphatic flow. From breathing techniques to gentle self-massage, you'll discover how small changes in your daily routine can make a big difference in how you feel. Whether you're dealing with swelling, fatigue, or just want to boost your immune system, this episode has something for you.Listen, learn, and unlock the power of your lymphatic system and start your journey to better wellness today!Connect with guest, Desiree De SponSend us a textHelp us spread the word about holistic healingPlease leave a review for Born to Heal: https://podcasts.apple.com/us/podcast/born-to-heal-holistic-healing-for-optimal-health/id1585725298 Take a screenshot, share it on your Instagram Stories, and tag @the.conscious.oncologist Don't Face Cancer Alone"The 6 Pillars of Healing Cancer" workshop series provides you valuable insights and strategies to support your healing journey - Click Here to Enroll MORE FROM KATIE DEMING M.D. Free Guide - 3 Things You Need to Know About Cancer: https://www.katiedeming.com/cancer-101/6 Pillars of Healing Cancer Workshop Series - Click Here to EnrollWork with Dr. Katie: www.katiedeming.comFollow Dr. Katie Deming on Instagram: The.Conscious.Oncologist Take a Deeper Dive into Your Healing Journey: Dr. Katie Deming's Linkedin Here Please Support the Show Share this episode with a friend or family member Give a Review on Spotify Give a Review on Apple Podcast DISCLAIMER:The Born to Heal Podcast is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider.
In this World Shared Practice Forum Podcast, Drs. Adrienne Randolph and Aaron Bodansky explore the groundbreaking research findings that uncover the pathophysiological mechanism behind multisystem inflammatory syndrome in children (MIS-C). These findings shed light on the characteristic immune response of patients who develop MIS-C, and provide insight into the development of post-infectious auto-immune disease phenotypes. LEARNING OBJECTIVES - Describe the pathophysiology of MIS-C, including the clinical features and molecular immune response - Describe the immune dysregulation that results in MIS-C, including the role of autoantibodies and T-cell responses - Identify the potential connections between SARS-CoV-2 infection and the development of autoimmune responses - Recognize the implications of the study findings for other related conditions such as long COVID and sepsis AUTHORS Adrienne Randolph, MD, MSc Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Professor of Anaesthesia and Pediatrics Harvard Medical School Aaron Bodansky, MD Assistant Professor Pediatric Critical Care University of California, San Francisco School of Medicine DATES Initial publication: September 24, 2024. ARTICLES REFERENCED Bodansky A, Mettelman RC, Sabatino JJ Jr, et al. Molecular mimicry in multisystem inflammatory syndrome in children. Nature. 2024;632(8025):622-629. doi:10.1038/s41586-024-07722-4. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Randolph AG, Bodansky A, Burns JP. Unveiling MIS-C's Immune Response: Molecular Mimicry. 09/2024. OPENPediatrics. https://soundcloud.com/openpediatrics/unveiling-mis-cs-immune-response-molecular-mimicry-by-a-randolph-and-a-bodansky-openpediatrics
Send us a textHow can understanding mitochondrial health revolutionize your approach to chronic illness? Join us on the Vibrant Wellness Podcast as we welcome Laura Frontiero, an expert nurse practitioner and functional health consultant. Laura shares her journey from conventional to functional medicine, explaining how integrating a focus on mitochondrial health can transform your practice. By improving cellular energy production, you can significantly enhance patient outcomes—especially in gut health, immune function, and detoxification.In our discussion, we explore practical strategies to optimize gut health. Discover why addressing drainage pathways before targeting microbial imbalances is essential for better health outcomes. We also examine the impact of environmental toxins and nutrient deficiencies, highlighting their influence on interconnected body systems. Laura provides actionable detox routines and discusses the critical role stress and trauma play in chronic disease, offering holistic methods to support comprehensive healing.We also delve into how lifestyle changes, exercise, and nutrient supplementation contribute to brain and mitochondrial health. Learn about the benefits of high-intensity workouts, cold and heat exposure, and key supplements like B vitamins and CoQ10. Drawing from her collaboration with experts on "toxic brain" and detoxification summits, Laura emphasizes the importance of continuous learning and proactive health management. Don't miss this episode packed with valuable insights and practical tips to elevate your approach to functional wellness. Chapters:(00:00) Functional Medicine and Cellular Energy(09:54) Modern Approaches to Gut Health(15:49) Uncovering Nutrient Deficiencies and Chronic Health(24:35) Natural Approaches to Health and Wellness(37:36) Supporting Brain Health and Detoxifying(47:22) Enhancing Mitochondrial Health Through Lifestyle(55:03) Longevity Through Knowledge and Wellness Links:www.laurafrontiero.comJoin Over 18,000 Leading Medical Professionals and Become a Vibrant Wellness Provider Today! (https://portal.vibrant-wellness.com/#/sign-up)
Join Dr. Skip Wyss and Dr. Julie Wyss on the Prime Podcast as they delve into essential health tips for improving your child's immune system. In this episode, discover the crucial link between gut health and your nervous system, and learn how regular chiropractic care can significantly enhance your immune response. The doctors shed light on common signs of poor gut health, such as persistent coughs and runny noses, and emphasize the importance of good nutrition. They also address the benefits of fever as a natural immune response and the importance of a proactive approach in maintaining children's health. Packed with valuable insights and practical advice, this episode is a must-watch for parents looking to support their children's well-being. 00:00 Understanding the Link Between Gut Health and Sickness 01:17 Introduction to the Podcast and Hosts 01:55 Back-to-School Immune System Tips 03:45 The Importance of Gut Health and Nervous System 05:02 The Role of Chiropractic Care in Immune Response 07:34 Debunking Fever Myths and Immune Response 13:32 Stress, Inflammation, and Chiropractic Solutions 20:25 Conclusion and Final Thoughts https://theprimepediatricpodcast.libsyn.com =============================================== Order Standard Process Here: https://primefamilycenters.standardprocess.com ================================= Download our App Here: Apple Play Store: https://apps.apple.com/us/app/prime-family-chiropractic-app/id6474149243 Android: https://play.google.com/store/apps/details?id=com.ub378e75245a.app&pcampaignid=web_share ================================= Please like, subscribe, comment, and share this video! //Dr. Julie Wyss - Prime Family Chiropractic Centers// Dr. Julie Wyss DC is a highly respected chiropractor with a special focus on pediatric and pregnancy care. Her extensive training and experience in these areas has made her a trusted advisor to families seeking a tailored and personalized type of care focused on the body's ability to heal itself. As a mother herself, Dr. Wyss understands the unique challenges that come with pregnancy and postpartum recovery. She believes that chiropractic care can play a vital role in supporting the health and wellbeing of both mother and child during these transformative stages of life. In addition to prenatal care, Dr. Wyss specializes in postpartum care to help new mothers recover and regain their strength and vitality. She provides gentle adjustments and breathing exercises to address issues such as diastasis recti, pelvic floor dysfunction, and breastfeeding difficulties. //Dr. Skip Wyss - Prime Family Chiropractic Centers// “When you get the chance to change lives from their first days of existence, you do not take it lightly. But you can take it with a dash of light-hearted joy!” That's how Dr. Skip Wyss chooses to manage Prime Family Chiropractic Centers, a 15-year staple in his Green Bay Community. He decided to take that experience and developed the internationally recognized educational program, The Prime Coaching Company, focused on pediatric, prenatal, and family health. Dr. Skip is an internationally recognized speaker, ICPA certified pediatric chiropractor and host of The Prime Podcast. The show is a platform for his wife, Dr. Julie Wyss, and himself to provide incredible education and resources on having an incredible marriage, business, family, faith, and health for service providers and their community! // Prime Family Chiropractic Centers // Certified Prenatal and Pediatric Family Chiropractic Healthcare. Get Primed for life and success with healthcare re-imagined. Website: https://primefamilycenters.com/ Follow us on Social Media! Instagram: https://www.instagram.com/primefamilycenters/ Instagram: https://www.instagram.com/drjuliewyss/ Instagram: https://www.instagram.com/skip_wyss_dc/ Instagram: https://www.instagram.com/primepediatrics/ Facebook: https://www.facebook.com/PrimeFamilyCenters Facebook: https://www.facebook.com/profile.php?id=100094650643408 Facebook: https://www.facebook.com/DrJulieWyss YouTube: https://www.youtube.com/@PrimeFamilyChiropracticCenters #primefamilycenter #primefamilychiropracticcenters #primepodcast #adversity #winning #losing #chiropractic #chiropractor #neckpain #shoulderpain #nervoussystem #spinehealth #headacherelief #pediatricchiropractor #familychiropractor #childwellness #healthyhabits #nutritionandwellness #sportschiropractor #chiropractornearme #pregnancychiropractor #prenatalchiropractor #prenatalcare #babychiropractor #greenbaywi #greenbaywisconsin #greenbaychiro #drskipwyss #drjuliewyss Green Bay, WI Chiropractors Best Chiropractor in Green Bay, WI Prime Family Centers Green Bay, WI Prime Family Chiropractic Centers Green Bay, WI Pediatric Chiropractors Webster Technique Pediatric Certified Chiropractor Dr. Skip Wyss Dr. Julie Wyss
In this episode of the Prime Podcast, Dr. Skip and Dr. Julie Wyss dive deep into the topic of children's stress and its effects on their behavior and health. They discuss common symptoms like tics, muscle twitches, and changes in posture that can arise from stress, especially as children prepare to return to school. The episode highlights the importance of proper brain-body communication, the role of chiropractic care in alleviating stress, and practical tips for parents to help their children adapt to stressful environments. The hosts also touch upon the misdiagnoses of conditions like ADHD and ADD that can stem from chronic stress and offer strategies to support both children and adults during high-stress periods. Tune in to learn how to better understand and mitigate stress in your child's life. 00:00 Introduction to ADHD and Children's Challenges 01:04 Welcome to the Podcast 01:20 Back-to-School Anxiety and Tics 02:43 Chiropractic Solutions for Stress 04:57 Signs of Stress in Children 08:44 Balance and Neurological Health 12:17 Stress and Immune Response 15:03 Conclusion and Upcoming Topics https://theprimepediatricpodcast.libsyn.com =============================================== Order Standard Process Here: https://primefamilycenters.standardprocess.com ================================= Download our App Here: Apple Play Store: https://apps.apple.com/us/app/prime-family-chiropractic-app/id6474149243 Android: https://play.google.com/store/apps/details?id=com.ub378e75245a.app&pcampaignid=web_share ================================= Please like, subscribe, comment, and share this video! //Dr. Julie Wyss - Prime Family Chiropractic Centers// Dr. Julie Wyss DC is a highly respected chiropractor with a special focus on pediatric and pregnancy care. Her extensive training and experience in these areas has made her a trusted advisor to families seeking a tailored and personalized type of care focused on the body's ability to heal itself. As a mother herself, Dr. Wyss understands the unique challenges that come with pregnancy and postpartum recovery. She believes that chiropractic care can play a vital role in supporting the health and wellbeing of both mother and child during these transformative stages of life. In addition to prenatal care, Dr. Wyss specializes in postpartum care to help new mothers recover and regain their strength and vitality. She provides gentle adjustments and breathing exercises to address issues such as diastasis recti, pelvic floor dysfunction, and breastfeeding difficulties. //Dr. Skip Wyss - Prime Family Chiropractic Centers// “When you get the chance to change lives from their first days of existence, you do not take it lightly. But you can take it with a dash of light-hearted joy!” That's how Dr. Skip Wyss chooses to manage Prime Family Chiropractic Centers, a 15-year staple in his Green Bay Community. He decided to take that experience and developed the internationally recognized educational program, The Prime Coaching Company, focused on pediatric, prenatal, and family health. Dr. Skip is an internationally recognized speaker, ICPA certified pediatric chiropractor and host of The Prime Podcast. The show is a platform for his wife, Dr. Julie Wyss, and himself to provide incredible education and resources on having an incredible marriage, business, family, faith, and health for service providers and their community! // Prime Family Chiropractic Centers // Certified Prenatal and Pediatric Family Chiropractic Healthcare. Get Primed for life and success with healthcare re-imagined. Website: https://primefamilycenters.com/ Follow us on Social Media! Instagram: https://www.instagram.com/primefamilycenters/ Instagram: https://www.instagram.com/drjuliewyss/ Instagram: https://www.instagram.com/skip_wyss_dc/ Instagram: https://www.instagram.com/primepediatrics/ Facebook: https://www.facebook.com/PrimeFamilyCenters Facebook: https://www.facebook.com/profile.php?id=100094650643408 Facebook: https://www.facebook.com/DrJulieWyss YouTube: https://www.youtube.com/@PrimeFamilyChiropracticCenters #primefamilycenter #primefamilychiropracticcenters #primepodcast #adversity #winning #losing #chiropractic #chiropractor #neckpain #shoulderpain #nervoussystem #spinehealth #headacherelief #pediatricchiropractor #familychiropractor #childwellness #healthyhabits #nutritionandwellness #sportschiropractor #chiropractornearme #pregnancychiropractor #prenatalchiropractor #prenatalcare #babychiropractor #greenbaywi #greenbaywisconsin #greenbaychiro #drskipwyss #drjuliewyss Green Bay, WI Chiropractors Best Chiropractor in Green Bay, WI Prime Family Centers Green Bay, WI Prime Family Chiropractic Centers Green Bay, WI Pediatric Chiropractors Webster Technique Pediatric Certified Chiropractor Dr. Skip Wyss Dr. Julie Wyss TAGS: Prime Podcast, Dr.Julie Wyss, Dr.Skip Wyss, Greenbay, Wisconsin, Chiropractors,
In this episode, we dive into the critical role of HLA gene variants, such as HLA-DRB1, and their profound impact on immune system function, particularly focusing on their significance in conditions like Lyme disease and mold toxicity. We'll explore how variations in these HLA genes, like the HLA-DRB1*0401 allele, influence the body's ability to recognize and respond to pathogens, potentially leading to chronic symptoms. The discussion will also cover HLA gene variant testing and how it can lend insight when it comes to taking a bioindividual approach to supporting the immune system. Topics: 1. Introduction - Explanation of HLA gene variants - Importance of HLA genes in immune system function 2. Basics of Genetics and Immunology - What is a chromosome? - Introduction to genes and their functions - Overview of DNA and protein synthesis 3. Major Histocompatibility Complex (MHC) - Description of the Major Histocompatibility Complex - Division of MHC genes into Class I, II, and III - Role of Class I MHC genes in antigen presentation - Role of Class II MHC genes in antigen presentation - Function of Class III MHC genes 4. HLA Genes and Immune Function - Explanation of Human Leukocyte Antigen (HLA) genes - Connection between MHC genes and HLA genes (human MHC) - Transcription and regulation of HLA genes - Response to internal and external signals - Role of Antigen-presenting cells (APCs) 5. Pathogen Recognition and Immune Activation - Mechanism of pathogen recognition by HLA genes - Activation of immune response by antigen presentation - Formation and function of peptide-HLA complexes 6. Impact of HLA Variants on Disease - Specific focus on Lyme disease and mold toxicity - Role of HLA Class II alleles in immune response - Association of HLA-DR alleles with chronic Lyme disease - Sensitivity to mold exposure linked to certain HLA gene variants 7. Testing and Implications of HLA Gene Variants - Importance of HLA gene variant testing - Broader implications for diseases like lupus and multiple sclerosis - Personalized approaches based on HLA gene variants 8. Biotoxin Illness and Poor Antigen Presentation Due to an HLA Gene Variant - Strategies to support immune system function in the presence of biotoxins - Importance of detoxification pathways and binders Thank you to our episode sponsor: Liver Medic Use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Try powerful new alternative therapies to get your life back on track. Book a consultation at Gentle Wellness Center today! More details can be found at https://www.mygentlewellness.com/ Gentle Wellness Center City: Fairfax Address: 12011 Lee Jackson Memorial Highway, STE 420 Website: http://www.mygentlewellness.com Phone: +1-703-996-3999 Email: info@mygentlewellness.com
BUFFALO, NY- July 1, 2024 – A new #review paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 12, entitled, “Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?” Two recent seminal works have untangled the intricate role of tumor-associated senescent cells in cancer progression, or regression, by guiding our immune system against cancer cells. The characterization of these unique, yet diverse cell populations, should be considered, particularly when contemplating the use of senolytics, which are drugs that selectively eliminate senescent cells, in a cancer framework. In this new review, researchers João Pessoa, Sandrina Nóbrega-Pereira, and Bruno Bernardes de Jesus from the University of Aveiro describe the current knowledge in this field. “In particular, we will discuss how the presence of senescent cells in tumors could be used as a therapeutic target in immunogenic cancers and how we may hypothetically design an adaptive anti-aging vaccine.” DOI - https://doi.org/10.18632/aging.205975 Corresponding authors - Bruno Bernardes de Jesus - brunob.jesus@ua.pt Video short - https://www.youtube.com/watch?v=hbhkSu1kX5Y Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205975 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cancer, immunotherapy, tumor-associated senescent cells, senescence, antigen, vaccine About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM
In this week's episode we'll learn about fitusiran prophylaxis in patients with hemophilia A or B, with or without inhibitors. Next we'll hear about new findings that heterozygous germline variants in the NBN gene that are linked to increased risk of B-cell acute lymphoblastic leukemia in children. Finally, we'll explore new insights on the histone demethylase PHF8, which has been identified as a master regulator of cell-intrinsic immune responses in acute myeloid leukemia. Featured Articles:Fitusiran prophylaxis in people with hemophilia A or B who switched from prior BPA/CFC prophylaxis: the ATLAS-PPX trialGermline genetic NBN variation and predisposition to B-cell acute lymphoblastic leukemia in children Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia
BUFFALO, NY- May 20, 2024 – A new research paper was published in Oncotarget's Volume 15 on May 16, 2024, entitled, “The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response.” The diheteroarylamide-based compound 1C8 and the aminothiazole carboxamide-related compound GPS167 inhibit the CLK kinases, and affect the proliferation of a broad range of cancer cell lines. A chemogenomic screen previously performed with GPS167 revealed that the depletion of components associated with mitotic spindle assembly altered sensitivity to GPS167. In this new study, researchers Lulzim Shkreta, Johanne Toutant, Aurélie Delannoy, David Durantel, Anna Salvetti, Sophie Ehresmann, Martin Sauvageau, Julien A. Delbrouck, Alice Gravel-Trudeau, Christian Comeau, Caroline Huard, Jasmin Coulombe-Huntington, Mike Tyers, David Grierson, Pierre-Luc Boudreault, and Benoit Chabot from Université de Sherbrooke, Université de Lyon, Institut de recherches cliniques de Montréal, Université de Montréal, and University of British Columbia a similar screen performed with 1C8 also established the impact of components involved in mitotic spindle assembly. “Accordingly, transcriptome analyses of cells treated with 1C8 and GPS167 indicated that the expression and RNA splicing of transcripts encoding mitotic spindle assembly components were affected.” The functional relevance of the microtubule connection was confirmed by showing that subtoxic concentrations of drugs affecting mitotic spindle assembly increased sensitivity to GPS167. 1C8 and GPS167 impacted the expression and splicing of transcripts in pathways relevant to tumor progression, including MYC targets and the epithelial mesenchymal transition (EMT). Finally, 1C8 and GPS167 altered the expression and alternative splicing of transcripts involved in the antiviral immune response. Consistent with this observation, depleting the double-stranded RNA sensor DHX33 suppressed GPS167-mediated cytotoxicity on HCT116 cells. “Our study uncovered molecular mechanisms through which 1C8 and GPS167 affect cancer cell proliferation as well as processes critical for metastasis." DOI - https://doi.org/10.18632/oncotarget.28585 Correspondence to - Benoit Chabot - benoit.chabot@usherbrooke.ca Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28585 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, CLK kinases inhibitors, EMT, antiviral immune response, microtubules, metastasis About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Most of us understand that the immune system ramps up in defense of the body in response to a stressor. But what happens when the system doesn't return to homeostasis? How can we quiet things back down and return balance when the immune system has become overactive, as with auto-immune disorders? On this episode of Vitality Radio, Jared invites Jim LaValle back on to discuss how plant sterols and sterolins can support the immune system to return to a balanced state. They also discuss what may be at the root of auto-immune diseases as well as mast cell, and histamine issues. You'll learn how you can rebalance your immune system as well as how you can support it to function at its best.Products:ModuCarePrecision Probiotic Vital SporesProtocol:#395: How Aged Garlic Extract Benefits Every System In Your Body with Dr. Jim LaValle#395: How Aged Garlic Extract Benefits Every System In Your Body with Dr. Jim LaValleVisit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
Today Jess is talking about immunity, and why it is important to support your child's immune system before winter.Parents generally focus on building their children's immunity during winter. However, focusing on supporting your children's (and your) immune system in autumn gives you the best chance of fighting off colds, and flu when winter time approaches. In this episode, Jess will discuss:How the immune system develops as a child ages; The different parts of the immune system; How innate immunity and adaptive immunity work together;The normal symptoms of illness and how often it is normal to be sick;How to determine if your child has a healthy immune system Stay tuned for next week's episode where Jess dives into antibiotics, the antibiotic cycle, and how we can avoid overuse of medications in our kids over the winter. Episode links:Immune Support Masterclass
In this episode, I delve deep into skin health and the hidden connections between your gut and your skin's condition. I'll talk about the truth behind chronic skin issues like acne, eczema and psoriasis, including why they're more than just surface-level problems. Join me as I uncover the root causes of these conditions, exploring the pivotal role of diet, stress and environmental factors in skin health. I'll share practical insights, backed by science, and offer actionable tips to help you reclaim control over your skin and enhance your overall well-being. In this episode: 00:00 - Introduction 02:38 - Root Causes of Chronic Skin Conditions 04:56 - Inflammation and Immune Response 06:00 - The Role of Gut Health 09:29 - Impact of Diet and Nutrient Absorption on Skin Health 11:27 - Stress and Emotional Health 12:39 - Detoxification Pathways 13:39 - Lifestyle Changes and Tips for Healthy Skin 19:14 - Final Thoughts Remember to like, subscribe, and share this episode with anyone who could benefit from it. And as always, thank you for tuning in to the Primal Shift Podcast! Links: Get a quick reference guide on what to eat for optimal health in my downloadable animal based food and beverage list. Diet is the main driver of skin health, but a daily skincare regimen can also help. I use OneSkin to help keep my skin looking and feeling great. If your skin issues are related to problems in your digestive tract, supplements like Intelligence of Nature (ION+), bovine colostrum and freeze-dried beef organs can help repair the delicate lining inside your gut and ensure you're absorbing all the essential micronutrients your skin needs to heal. To lean more about how environmental toxins can negatively impact your skin health, check out How Xenoestrogens Make Us Sick, Fat and Infertile (with Dr. Anthony Jay) and the Top Non-Toxic Household and Personal Care Products (We Use at Home) Thank you to this episode's sponsor, MK Supplements! Use code “primalshift” to save 15% on your MK Supplements order at https://shop.michaelkummer.com More From Michael Kummer: Website: https://michaelkummer.com YouTube: https://youtube.com/@MichaelKummer Instagram: https://instagram.com/mkummer82
In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significantly enhanced markers of adaptive immunity, while the vegan diet was associated with increased innate immune function.The hosts unpack these findings, discussing the potential mechanisms behind the divergent immune signatures, the limitations of the short-term study design, and the need for further research.They also highlight the importance of carefully standardizing the macronutrient and micronutrient compositions of the dietary interventions to isolate the key drivers of the observed changes.Overall, this episode provides a thought-provoking look at the profound impacts that diet can have on the functioning of our immune system, setting the stage for future studies exploring the therapeutic potential of nutritional approaches.This episode is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at https://gdx.net/themetaboliclinkAs mentioned in the introduction, you can watch the free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health hereIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
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Dr. Penner describes two primary factors of gut health to be absorption and barrier function or permeability. His lab's work on permeability is suggesting that intestinal regions really drive total gut permeability to a much greater extent than ruminal permeability in dairy cows. (7:06)Ms. Bertens is Dr. Penner's Ph.D. student and explains some new methodologies she developed for measuring gut permeability using chromium EDTA and cobalt EDTA. It's common to use an oral dose of chromium EDTA as a marker to measure total tract permeability. Claire's work, using cannulated cows, used a ruminal dose of chromium EDTA for total tract permeability and an abomasal dose of cobalt EDTA for post-ruminal permeability. Both of these markers are indigestible, non-metabolizable and have no transcellular transport mechanisms. Claire is working to publish the new method as a complete validation study has been completed. (9:15)While this method is currently limited to using cannulated animals, Greg and Claire could envision a less sophisticated and more applied on-farm technique to assess permeability. Until then, there are still a lot of management observations that can identify potential issues with gut permeability. The appearance of feces and the presence of mucin casts can both be indicative of gut issues. Certainly dry matter intake is a major influencer on gut health, and Claire also sees potential in new technologies like rumination collars or rumination ear tags. (13:47)Are there certain time points in a dairy cow's life when she is at risk for increased gut permeability? Dr. Penner describes research suggesting if weaning is implemented too abruptly, that really increases the risk for decreased barrier function of the gut. Erratic feed intake patterns resulting from withholding feed for any reason at any age can also increase the risk of leaky gut. For example, depressed intake during the transition phase, along with anything that drives a response through an underlying systemic inflammatory response, probably creates risky situations for leaky gut. Claire is currently running a study looking at the impacts of intramammary LPS infusion on gut function. Greg envisions that learning more about gut function could create a new philosophy for treating sick animals. In the past, only antimicrobials were used to treat mastitis, but now it's common to also treat with a NSAID for pain. Perhaps in the future, we will also provide treatment to accelerate the recovery of the gut to prevent secondary disorders. (16:15)How long does an off-feed event have to last to cause an issue in the gut? It seems a fairly acute time period is all that is needed. Most studies are trying to replicate what happens on-farm, for example during mastitis, heat stress or the transition period. Greg indicates that not only will permeability be impacted, but ruminal absorptive capacity can also decline rapidly in these conditions. In Claire's LPS challenge study, cows' rectal temperatures peak around six hours after the LPS infusion and usually resolve within 12 hours. But most cows do not eat for a solid 12 hours during the challenge, and they are slow to recover feed intake over the next few days. In cows that aren't sick but experience feed restriction in experimental protocols, they tend to overeat when they are allotted the full ration and this can lead to ruminal acidosis. (21:57)Increased incidences of liver abscesses in beef-on-dairy calves are being reported in the industry. Dr. Penner speculates that perhaps these calves are not always achieving adequate passive transfer, and may not be receiving high enough levels of milk replacer to support a more robust immune system. It may be the increased beef cattle genetics in the calves are putting an added requirement on growth or muscle development that may not be met by lower levels of milk replacer or even lower colostrum feeding levels. (34:40)In closing, providing cows with a consistent environment where they can meet their needs by their own behavior such as free access to feed when hungry and to a comfortable stall when it's time to rest. Cows reward consistency with health and production. Gut health in a commercial setting is a relevant issue and it might go undiagnosed or undetected. Research into where in the gut permeability is occurring will help define strategies to modulate response. While off-feed events for individual animals might be harder to recognize in a large dairy environment, new technology may allow for earlier diagnosis. (40:43)Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table. If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.
Until recently, doctors didn’t think it made a difference which arm patients got their COVID-19 vaccine in. But a new study from Oregon Health & Science University shows that switching arms between doses could lead to as much as a fourfold increase in immune response. Though further studies are necessary, researchers suspect the improvement has to do with how the body learns to protect itself against viruses, meaning the results could be replicated in other multi-dose vaccine regimens. Marcel Curlin is an associate professor of medicine and the medical director for occupational health at OHSU. He joins us to talk about what these findings could mean for future vaccine protocols.
A little less than a month after hearing oral arguments, the DC Circuit Court of Appeals has rejected Donald Trump's argument that he is immune from being prosecuted for acts within the “outer perimeter” of his presidential duties. That should clear the way for Judge Tanya Chutkan to again move toward the start of a criminal trial, unless the Supreme Court decides it wants to consider the case. Ken and Josh talk about the judges' reasoning, reasons the Supreme Court might decide to sit this one out, and when Chutkan could realistically proceed toward trial under various scenarios.Plus: Fani Willis' responds to a Georgia RICO defendant regarding her personal relationship with the special prosecutor she hired to oversee the case, Taylor Swift's lawyers send a nastygram to a college student tracking her private plane, Jack Burkman's giving up his law license, and it turns out that the Senate employee who filmed a sex tape in the Hart Building had the good sense to exercise his Fifth Amendment right not to talk to Capitol Police, which means he has better judgment than about half the people we talk about on this show.Visit serioustrouble.show to sign up for our newsletter and to find transcripts of our episodes. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.serioustrouble.show/subscribe
Today, I am blessed to have Dr. Eric Berg here with me. He is The Knowledge Doc, and he founded the Berg Institute of Health & Wellness in 1997 in Seminole, Florida, where he now serves as the Institute's CEO. The Institute aims to help people understand their health, their body's needs, and how to overcome nutritional deficiencies. Dr. Berg enables people to take ownership of their health and well-being to achieve their ideal weight loss goals empowered by a keto diet and intermittent fasting. In this episode, Dr. Berg chats about modern health challenges, shedding light on fat storage mechanisms, the role of ketones as a cleaner fuel, and the impact of abundant food availability on our health. Dr. Berg debunks common myths surrounding insulin responses to fat, sugar, and protein, emphasizing the crucial role of glucagon in maintaining a balanced physiological state. We dive into the intricate relationship between inflammation, the immune response, and dietary triggers, mainly focusing on the long-term consequences of chronic inflammation induced by certain foods. Plus, Dr. Berg challenges the conventional view of cholesterol, highlighting the essential functions of LDL in the body's healing processes. Moreover, he exposes censorship and disinformation campaigns against the ketogenic diet, calling for grassroots action to counter organized opposition and increase awareness about the benefits of a keto lifestyle. Dr. Berg advocates for a collective effort to create demand for whole, nutritious foods to influence market dynamics and discourage the promotion of processed or lab-based alternatives.
Forever Young Radio Show with America's Natural Doctor Podcast
Most of us are born with an immune response capable of warding off many unwanted invaders. This system is designed to protect the body from germs in order to keep itself healthy.However, due to our sedentary lifestyles and poor eating habits, and the pandemic, many are in need of an immune reboot.It's even more necessary with the cold weather that has already begun to creep its way across the country.Not to worry though. We've got some tips that may help improve the body's immune response, setting you up for a more enjoyable and relaxing experience during the cold months. Learn more at Foreveryoungradio.com and read this helpful article
Seasonality of Immune Response: Could Gingival Inflammation Have a Seasonal Component? By Spring Hatfield, RDH, BSPH Original article published on Today's RDH: https://www.todaysrdh.com/seasonality-of-immune-response-could-gingival-inflammation-have-a-seasonal-component/ This audio article is sponsored* by LISTERINE®. Although LISTERINE® Antiseptic is the most extensively tested over-the-counter mouthrinse in the world, with over 30 long-term clinical trials examining its safety and efficacy, there is still some misinformation out there over the uses of mouthrinses containing alcohol. To help understand the safety of alcohol-containing mouthrinses, in case any patients ask you about it, head on over to https://rdh.tv/ListerineSafety Need CE? Start earning CE credits today at https://rdh.tv/ce Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/ Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/ Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh/
This episode is truly a thought-provoking conversation about Alzheimer's and its unique impact on women with none other than the legendary Dr. Dale Bredesen (who is making his fourth appearance on the show). Dale Bredesen, MD, received his undergraduate degree from Caltech and his medical degree from Duke University. He served as resident and chief resident in neurology at the University of California, San Francisco (UCSF) and as postdoctoral fellow in the laboratory of Nobel Laureate Professor Stanley Prusiner. He was a faculty member at UCLA from 1989 to 1994 and was then recruited by the Burnham Institute to direct the Program on Aging. In 1998, he became the founding president and CEO of the Buck Institute for Research on Aging and adjunct professor at UCSF. In 2013, he returned to the University of California, Los Angeles (UCLA) as director of the Easton Center for Alzheimer's Disease Research and he is currently a professor.Dr. Stephanie and Dr. Bredesen delve into the fascinating topic of Alzheimer's as a preventable condition, emphasizing that this is the first generation with the power to make Alzheimer's truly optional. They explore the shift in the common presentation of Alzheimer's, particularly in women, highlighting the rise of subjective or mild cognitive impairment in 52-year-old women.As always, Dr. Stephanie and Dr. Bredesen provide actionable solutions for preventing and managing Alzheimer's, covering diet, exercise, sleep, supplementation, and testing. They introduce innovative blood tests, discuss the importance of a "cognoscopy," and even touch on dental health's role in brain health.Resources Mentioned:Reversal of Cognitive Decline: 100 Patients - https://www.omicsonline.org/open-access/reversal-of-cognitive-decline-100-patients-2161-0460-1000450-105387.htmlTranscriptional Effects of ApoE4: Relevance to Alzheimer's Disease - Transcriptional Effects of ApoE4: Relevance to Alzheimer's DiseaseReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline. - https://pubmed.ncbi.nlm.nih.gov/34680464/Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? - https://pubmed.ncbi.nlm.nih.gov/36774227/Reversal of cognitive decline: a novel therapeutic program - https://pubmed.ncbi.nlm.nih.gov/25324467/Reversing the effects of Alzheimer's Disease: Dr. Ron Geyer on NeuroEPO - https://medicine.usask.ca/news/2023/reversing-the-effects-of-alzheimers-disease-dr.-ron-geyer-on-neuroepo.phpDr. Bredesen's TedX talk - https://youtu.be/TzJSCttlQmc?si=sEC_psvctDR0XRkzDr. Bredesen's books - https://www.apollohealthco.com/books/KetoFLEX 12/3™ - https://ketoflex.apollohealthco.comEvanthea Dementia Reversal Trial - https://www.dementiareversaltrial.comInstagram - https://www.instagram.com/drdalebredesen/Episode Overview:0:00:00 Introduction0:05:42 Welcome to Dr. Dale Bredesen0:11:59 Factors driving the shift in Alzheimer's disease onset age0:15:41 COVID-19 and Alzheimer's disease risk0:21:28 The importance of addressing chronic conditions0:24:01 The role of metabolic health in cognitive decline0:25:40 The role of diet in Alzheimer's disease0:26:54 The postmenopausal women and cognitive decline0:35:05 Alzheimer's disease and genetic factors0:36:53 How we could confuse perimenopause with Alzheimer's0:44:39 ApoE4 and the evolution of hominids0:47:42 ApoE4 and its pro-inflammatory effect0:51:23 The limitations of targeting neurofibrillary tangles and plaques0:54:23 Evaluating the efficacy of drugs for Alzheimer's treatment1:04:39 Exploring the use of supplementation in the trial1:05:45 The seven fundamentals for maintain good brain health1:13:57 Importance of sleep hygiene and nasal breathing1:18:38 Tailoring sleep habits to circadian rhythms and environmental factorsWe'd like to thank our sponsors:Go to neurohacker.com/better to try Qualia Senolytic with a 100 day money back guarantee, and code BETTER will get you 15% off your order.Right now Levels is offering you an additional two free months off of the levels annual membership when you use the link levels.link/better.If you want to try Beam Minerals for yourself, head over to beamminerals.com/better for 20% off of the entire store.
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