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  • 291PODCASTS
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Best podcasts about compounds

Latest podcast episodes about compounds

MS Living Well: Key Info from Multiple Sclerosis Experts
Multiple Sclerosis Clinical Trials

MS Living Well: Key Info from Multiple Sclerosis Experts

Play Episode Listen Later Oct 14, 2021 42:28


Interested in improving MS care? Participating in a clinical trial may have personal advantages and help others in the future. Trial design discussed including whether or not a placebo (no treatment) will be used. Criteria needed to enroll in a clinical study called inclusion and exclusion criteria explained. Key elements of clinical trials outlined including multiple safety measures and informed consent. Current clinical trials in multiple sclerosis are covered including using highly effective treatment early for someone living with multiple sclerosis. Current studies in progressive MS and remyelination shared. Compounds highlighted include BTK inhibitors, masitinib, ibudilast, simvastatin and gold nanocrystals. Barry Singer MD, Director of The MS Center for Innovations in Care, interviews: Jiwon Oh MD PhD is the Director of the BARLO MS Centre at St. Micheal's Hospital in Toronto. She is an Associate Professor of Neurology University of Toronto. Dr. Oh's research focuses on developing advanced imaging techniques of the spinal cord and brain for use in clinical settings. She is the principal investigator on local and collaborative, multi-center MRI studies. Dr. Oh is the lead of the Canadian National Progression Cohort, which is focused on better understanding progression in MS. She completed her undergraduate degree at the University of Toronto and medical school from Queen's University. Dr. Oh completed her residency at the University of Toronto, PhD in Public Health at John Hopkins and neuroimmunology fellowship at John Hopkins. Robert Bermel MD is a neurologist specializing in multiple sclerosis at the Mellen Center for Multiple Sclerosis at Cleveland Clinic. He received a medical degree with thesis honors from the State University of New York at Buffalo. Dr. Bermel completed his neurology residency training and served as Chief Resident at Cleveland Clinic. He was funded as a National MS Society postdoctoral fellow in clinical neuroimmunology and advanced imaging at Cleveland Clinic. Dr. Bermel cares for patients, conducts imaging research, and an investigator in multiple clinical trials at the Mellen Center. His current research interests focus on the identification of advanced imaging methods to evaluate and improve recovery from inflammatory demyelinating disease. Visit www.mslivingwell.org for more information.

The Medical Journal of Australia
Episode 443: MJA Podcasts 2021 Episode 42: Potentially harmful compounds in e-liquids, with Associate Professor Alex Larcombe

The Medical Journal of Australia

Play Episode Listen Later Oct 9, 2021 17:34


Vol 215, Issue 8: 11 October 2021. Associate Professor Alexander Larcombe is Program Head of Respiratory Health at Telethon Kids Institute in Perth. He discusses the potentially harmful chemical compounds he and his colleagues found in a range of e-liquids available for purchase in Australia. With MJA news and online editor, Cate Swannell. The research is free to access and can be found at https://www.mja.com.au/journal/2021/potentially-toxic-compounds-found-vaping-liquids ... Guidance for GPs on the new prescribing legislation for e-cigarettes can be found at https://www.racgp.org.au/clinical-resources/clinical-guidelines/key-racgp-guidelines/view-all-racgp-guidelines/supporting-smoking-cessation

Anti Aging Hacks
Is NAD One Of The Top Anti-Aging Compounds In The World, Plus It's Use In Treating Addiction: Tom Ingoglia

Anti Aging Hacks

Play Episode Listen Later Sep 17, 2021 55:18


NAD stands for Nicotinamide Adenine Nucleotide. It is essential to the creation of energy in the body and coordinating cellular processes. It's a critical coenzyme found in every cell in your body. Tom Ingoglia's life changed when he was infected with Lyme disease because he experienced adverse drug reactions that spiraled into drug addiction. But his rock bottom was losing half his family in the same week. Tom dedicated himself to healing over eight years, found intravenous NAD⁺ therapy, and miraculously regained his health. He went on to spearhead IV NAD therapies in the clinic he created.   ------------------------ If you're looking to improve your hair wellness and get thicker, stronger and longer hair, make sure to check out https://fullyvital.com ------------------------ Topics of Discussion: - How Did Tom Find NAD? - Why Is NAD So Important For Anti-Aging and Health? - What Happens To NAD Levels As We Get Older - How Is NAD Made In the Body? - How Can You Get NAD From External Sources - Who Are The NAD Pioneers? - What's Tom's Involvement with NAD - Where to Get Some NAD Patches That You Can Try Out (use discount code FARAZ15) Check out the detailed show notes at https://antiaginghacks.net/nad

The Brü Lab
Episode 030 | Phenolic Compounds In Beer w/ Dr. Mike Lentz

The Brü Lab

Play Episode Listen Later Sep 15, 2021 67:44


Dr. Mike Lentz, associate professor in the Department of Biology at the University of North Florida, joins Cade in the lab to discuss his work looking at the impact phenolic compounds have on beer character.  The Brü Lab is brought to you by Imperial Yeast who provide brewers with the most viable and fresh yeast on the market. Learn more about what Imperial Yeast has to offer at ImperialYeast.com today. | Read More | The Impact of Simple Phenolic Compounds on Beer Aroma and Flavor Ferulic Acid Rest xBmt Underpitch vs. Overpitch In Weissbier xBmt

Podcast Notes Playlist: Latest Episodes
ADHD & How Anyone Can Improve Their Focus | Episode 37

Podcast Notes Playlist: Latest Episodes

Play Episode Listen Later Sep 15, 2021 138:01


Huberman Lab Podcast Notes Key Takeaways Attention deficit disorder (ADD) is now called Attention deficit hyperactivity disorder (ADHD) when it became clear there was a hyperactive componentDespite the stereotype, people with ADHD can be hyper-focused but only focus attention on things of interestDopamine is the neurotransmitter that underlies enjoyment and curiosity – most ADHD pharmaceuticals are stimulants with a play on the dopamine systemThere's a fine line between street drugs and therapeutics for ADHD: Ritalin is closely related to speed; Adderall closely resembles methamphetamineNon-pharmaceutical and behavioral treatments for ADHD may be used in combination with pharmaceuticals with the potential to wean off as possibleWhile research for elimination diets has been controversial as a treatment for ADHD, it seems like avoiding simple sugars and exploring allergies to make informed food choices is worthwhileNewer studies point to the idea that smartphone use is inducing ADHD in adolescence if used more than 60 minutes per day, and approximately 120 minutes per day in adultsRead the full notes @ podcastnotes.orgIn this episode, I discuss ADHD (Attention-Deficit Hyperactivity Disorder): what it is, the common myths, and the biology and psychology of ADHD. I discuss both behavioral and pharmacologic treatments for ADHD, and brain-machine interface tools. I also discuss behavioral training protocols that can improve focus in people with ADHD and those without ADHD, and for people of different ages. I discuss the role of dopamine in coordinating 'default-mode' and 'task-related' neural networks, attentional "blinks" (lapses of attention) and how to overcome them, and the role of actual blinks in time perception and attention. Finally, I review some of the prescription and over-the-counter compounds for increasing focus such as Adderall, Ritalin, Modafinil and Armodafinil, the racetams, Alpha-GPC and phosphatidylserine and the role of diet for managing ADHD (and the controversies of diet for ADHD). The role of cell phones/technology in ADHD and ADHD-like challenges with focus are also discussed. Throughout, both basic science and clinical scenarios, as well as applicable tools and resources are covered. Thank you to our sponsors: Roka - https://www.roka.com -- code "huberman" Belcampo - https://www.belcampo.com/huberman Helix Sleep - https://www.helixsleep.com/huberman   Our Patreon page: https://www.patreon.com/andrewhuberman   Supplements from Thorne: http://www.thorne.com/u/huberman   Support Research in the Huberman Lab at Stanford: https://hubermanlab.stanford.edu/giving   Social: Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab Website - https://hubermanlab.com Email Newsletter - https://hubermanlab.com/neural-network   Links: Review of Compounds for ADHD, Smart Drugs & Focus - https://www.fbscience.com/Landmark/articles/10.52586/4948 Review of Atypical Compounds for ADHD - https://www.hindawi.com/journals/np/2016/1320423/ Study of Focus Protocol In ADHD & Non-ADHD Children - https://www.mdpi.com/1660-4601/17/13/4780   Timestamps: 00:00:00 Introduction & Note About Diagnosis 00:03:27 Sponsors  00:07:56 ADHD vs. ADD: Genetics, IQ, Rates in Kids & Adults 00:13:00 Attention & Focus, Impulse Control 00:14:57 Hyper-focus  00:16:45 Time Perception 00:18:25 The Pile System 00:20:00 Working Memory 00:24:10 Hyper-Focus & Dopamine  00:26:40 Neural Circuits In ADHD: Default Mode Network & Task-Related Networks  00:32:57 Low Dopamine in ADHD & Stimulant Use & Abuse 00:37:10 Sugar, Ritalin, Adderall, Modafinil & Armodafinil  00:47:00 Non-Prescribed Adderall, Caffeine, Nicotine 00:49:18 How Stimulants “Teach” the Brains of ADHD Children to Focus 00:52:00 When To Medicate: A Highly Informed (Anecdotal) Case Study 00:56:35 Elimination Diets & Allergies In ADHD 01:04:46 Omega-3 Fatty Acids: EPAs & DHAs  01:07:00 Modulation vs Mediation of Biological Processes 01:10:50 Attentional Blinks  01:16:56 Open Monitoring & 17minute Focus Enhancement  01:22:50 Blinking, Dopamine & Time Perception; & Focus Training  01:30:10 Reverberatory Neural & Physical Activity 01:33:40 Adderall, Ritalin & Blink Frequency 01:35:00 Cannabis  01:37:30 Interoceptive Awareness  01:41:15 Ritalin, Adderall, Modafinil, Armodafinil; Smart Drugs & Caffeine: Dangers 01:48:05 DHA Fatty Acids, Phosphatidylserine 0:1:50:54 Ginko Biloba  01:51:45 Modafinil & Armodafanil: Dopamine Action & Orexin 01:56:19 Acetylcholine: Circuits Underlying Focus; Alpha-GPC 01:59:04 L-Tyrosine, (PEA) Phenylethylamine  02:01:23 Racetams, Noopept  02:05:15 Transcranial Magnetic Stimulation; Combining Technology & Pharmacology  02:09:14 Smart Phones & ADHD & Sub-Clinical Focus Issues In Adults & Kids 02:14:30 Synthesis/Summary 02:16:10 Support for Podcast & Research, Supplement Resources   Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.   Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com 

The Field Church
Do You Suffer Well?

The Field Church

Play Episode Listen Later Sep 13, 2021 64:18


Do You Suffer Well? 1 Peter 5:5-7 David Grantham NOTES: Live victoriously for the Lord without: • Losing hope • Becoming bitter • Unrighteous anger • Damaging our witness Live victoriously for the Lord with: • Trust in the Lord • Looking forward to His second coming Four proper responses to persecution: 1. Expect it 2. Rejoice in it 3. Evaluate its cause 4. Entrust it to God Obedience produces: • A calmness in our physical body • A clarity in our minds • A peacefulness in our demeanor • An inner assurance of harmony with God • A gentleness in our actions Disobedience: • Is a stress multiplier • Compounds our anxieties • A waste of our life

Huberman Lab
ADHD & How Anyone Can Improve Their Focus | Episode 37

Huberman Lab

Play Episode Listen Later Sep 13, 2021 138:01


In this episode, I discuss ADHD (Attention-Deficit Hyperactivity Disorder): what it is, the common myths, and the biology and psychology of ADHD. I discuss both behavioral and pharmacologic treatments for ADHD, and brain-machine interface tools. I also discuss behavioral training protocols that can improve focus in people with ADHD and those without ADHD, and for people of different ages. I discuss the role of dopamine in coordinating 'default-mode' and 'task-related' neural networks, attentional "blinks" (lapses of attention) and how to overcome them, and the role of actual blinks in time perception and attention. Finally, I review some of the prescription and over-the-counter compounds for increasing focus such as Adderall, Ritalin, Modafinil and Armodafinil, the racetams, Alpha-GPC and phosphatidylserine and the role of diet for managing ADHD (and the controversies of diet for ADHD). The role of cell phones/technology in ADHD and ADHD-like challenges with focus are also discussed. Throughout, both basic science and clinical scenarios, as well as applicable tools and resources are covered. Thank you to our sponsors: Roka - https://www.roka.com -- code "huberman" Belcampo - https://www.belcampo.com/huberman Helix Sleep - https://www.helixsleep.com/huberman   Our Patreon page: https://www.patreon.com/andrewhuberman   Supplements from Thorne: http://www.thorne.com/u/huberman   Support Research in the Huberman Lab at Stanford: https://hubermanlab.stanford.edu/giving   Social: Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab Website - https://hubermanlab.com Email Newsletter - https://hubermanlab.com/neural-network   Links: Review of Compounds for ADHD, Smart Drugs & Focus - https://www.fbscience.com/Landmark/articles/10.52586/4948 Review of Atypical Compounds for ADHD - https://www.hindawi.com/journals/np/2016/1320423/ Study of Focus Protocol In ADHD & Non-ADHD Children - https://www.mdpi.com/1660-4601/17/13/4780   Timestamps: 00:00:00 Introduction & Note About Diagnosis 00:03:27 Sponsors  00:07:56 ADHD vs. ADD: Genetics, IQ, Rates in Kids & Adults 00:13:00 Attention & Focus, Impulse Control 00:14:57 Hyper-focus  00:16:45 Time Perception 00:18:25 The Pile System 00:20:00 Working Memory 00:24:10 Hyper-Focus & Dopamine  00:26:40 Neural Circuits In ADHD: Default Mode Network & Task-Related Networks  00:32:57 Low Dopamine in ADHD & Stimulant Use & Abuse 00:37:10 Sugar, Ritalin, Adderall, Modafinil & Armodafinil  00:47:00 Non-Prescribed Adderall, Caffeine, Nicotine 00:49:18 How Stimulants “Teach” the Brains of ADHD Children to Focus 00:52:00 When To Medicate: A Highly Informed (Anecdotal) Case Study 00:56:35 Elimination Diets & Allergies In ADHD 01:04:46 Omega-3 Fatty Acids: EPAs & DHAs  01:07:00 Modulation vs Mediation of Biological Processes 01:10:50 Attentional Blinks  01:16:56 Open Monitoring & 17minute Focus Enhancement  01:22:50 Blinking, Dopamine & Time Perception; & Focus Training  01:30:10 Reverberatory Neural & Physical Activity 01:33:40 Adderall, Ritalin & Blink Frequency 01:35:00 Cannabis  01:37:30 Interoceptive Awareness  01:41:15 Ritalin, Adderall, Modafinil, Armodafinil; Smart Drugs & Caffeine: Dangers 01:48:05 DHA Fatty Acids, Phosphatidylserine 0:1:50:54 Ginko Biloba  01:51:45 Modafinil & Armodafanil: Dopamine Action & Orexin 01:56:19 Acetylcholine: Circuits Underlying Focus; Alpha-GPC 01:59:04 L-Tyrosine, (PEA) Phenylethylamine  02:01:23 Racetams, Noopept  02:05:15 Transcranial Magnetic Stimulation; Combining Technology & Pharmacology  02:09:14 Smart Phones & ADHD & Sub-Clinical Focus Issues In Adults & Kids 02:14:30 Synthesis/Summary 02:16:10 Support for Podcast & Research, Supplement Resources   Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.   Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com 

Proactive - Interviews for investors
Mindset Pharma says Family 3 psilocybin compounds show long-acting duration in preclinical trials

Proactive - Interviews for investors

Play Episode Listen Later Aug 27, 2021 5:54


Mindset Pharma Inc (CSE:MSET) (OTCQB:MSSTF) (FRA:9DF) CEO James Lanthier and CSO Joseph Araujo tell Proactive the group has released positive preclinical results from research on its Family 3 group of psilocybin compounds that could significantly improve the sustained effectiveness and safety profile of microdosing practices. Lanthier and Araujo say research on the compounds, comprised of long-acting psilocybin side-chain restricted analogs, demonstrated “extended duration of action” and decreased effect size at the 5-HT2A receptor. Lanthier says findings indicate the potential to change the paradigm of microdosing therapies by delivering the therapeutic benefits of psychedelics with limited potential to elicit a hallucinogenic experience at a wide range of effective doses.

Proactive - Interviews for investors
Mindset Pharma files newest US patent application for its Family 4 DMT compounds

Proactive - Interviews for investors

Play Episode Listen Later Aug 25, 2021 4:36


Mindset Pharma Inc (CSE:MSET) (OTCQB:MSSTF) (FRA:9DF) CEO James Lanthier and Chief Scientific Officer Joseph Araujo joined Proactive to discuss its new provisional patent application with the United States Patent and Trademark Office that extends its Family 4 compounds, a set of novel DMT/5-MeO-DMT analogs. Lanthier and Araujo say the most recent application covers a “comprehensive range” of next generation drug candidates, as well as their related chemical process synthesis, composition of matter and therapeutic uses.

Fundamental Health with Paul Saladino, MD
Ending the debate over seed oils, with Tucker Goodrich

Fundamental Health with Paul Saladino, MD

Play Episode Listen Later Aug 24, 2021 128:57


Tucker Goodrich is a technology executive in the financial industry who designs, runs, and debugs complex systems in high-risk environments. Areas of expertise include risk management, systems management, and cyber-security. After experiencing some personal health crises and realizing that the ‘solutions' offered by medical professionals weren't working or addressing causation he started applying the same approach in research and evaluation of data to his own health issues to determine root causes. His interests have focused on dietary and environmental drivers of chronic disease, including carbohydrate, wheat, and various classes of fats. Specifically, he's attempting to understand and popularize understanding of the mechanisms driving the diet-derived explosion in so-called chronic diseases (or diseases of civilization). He is active on twitter (@tuckergoodrich, has a blog called Yelling Stop, is an Expert Advisor for the nutrition start-up Nutrita, and has been a guest on numerous podcasts.   Time Stamps: 0:10:16 Podcast begins 0:12:16 Tucker's blog post: https://yelling-stop.blogspot.com/2021/06/thoughts-on-of-rats-and-sidney-diet.html 0:14:16 Compounds that reduce overeating 0:17:16 Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity: https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2012.38 0:23:31 Endocannabinoid signal in the gut controls dietary fat intake: https://www.pnas.org/content/108/31/12904 0:29:56 A Neural Circuit for Gut-Induced Reward: https://www.cell.com/cell/fulltext/S0092-8674(18)31110-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867418311103%3Fshowall%3Dtrue 0:35:46 CRP is a marker of oxidized linoleic acid 0:38:32 Dietary linoleic acid intake and blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials: https://pubs.rsc.org/en/content/articlelanding/2017/FO/C7FO00433H 0:43:06 Take a pill or just stop eating so many seed oils? 0:45:16 Low‐Density Lipoprotein Cholesterol Corrected for Lipoprotein(a) Cholesterol, Risk Thresholds, and Cardiovascular Events: https://www.ahajournals.org/doi/10.1161/JAHA.119.016318 0:49:46 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans: https://pubmed.ncbi.nlm.nih.gov/9844997/ 0:54:16 HNE - what is it and why is it important? 0:58:36 Where is linoleic acid even found? 1:02:46 The average amount of linoleic acid in the human diet 1:12:06 Why I don't eat bacon 1:14:46 Just because a study was conducted a long time ago, doesn't mean it should be ruled out 1:20:31 Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73): https://www.bmj.com/content/353/bmj.i1246 1:27:16 When low LDL can result in a higher risk of cardiovascular disease 1:28:31 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis: https://www.bmj.com/content/346/bmj.e8707 1:32:16 Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study: https://pubmed.ncbi.nlm.nih.gov/9989963/ 1:40:40 The blood test you should consider getting  1:42:55 The idea of "intralipid" 1:51:00 Tucker's personal experience with weight loss and dietary changes 2:03:10 Health Characteristics of the Wayuu Indigenous People: https://academic.oup.com/milmed/article/184/7-8/e371/5481850 2:07:25 Where to find more of Tucker Goodrich   Sponsors: Blazing Bull: $150 off of a 1500 degree grill at BlazingBullGrills.com with code “CARNIVOREMD” at checkout Lets Get Checked: 20% off your order at www.TRYLGC.com/carnivoremd  White Oak Pastures: www.Whiteoakpastures.com, use code: CarnivoreMD for 10% off your first order Belcampo: www.belcampo.com use code: CarnivoreMD for 20% off your order

Not Another Fitness Podcast: For Fitness Geeks Only
Episode 111: My Plant Medicine Experience w Ayahuasca and Kambo in Costa Rica

Not Another Fitness Podcast: For Fitness Geeks Only

Play Episode Listen Later Aug 17, 2021 83:05


Introduction to Marcos and his journeyWhat to considerLessons learnedHow my journey beganWhere I wentWhat I tookHow I feltMy takeawayWarningsMarcos https://www.linkedin.com/in/strongerfitnessMike Bledsoe on IG https://www.instagram.com/mike_bledsoe/?hl=enAn Urgent Plea to Users of Psychedelics: Let's Consider a More Ethical Menu of Plants and Compounds by Tim Ferrisshttps://tim.blog/2021/02/21/urgent-plea-users-of-psychedelics-ethical-plants-compounds/Amazon Conservation Team via Dr Mark Plotkinhttps://www.amazonteam.org/Kambo Casita, Nosoro Costa Rica  https://www.kambocasita.com/Multidisciplinary Association for Psychedelic Studies (MAPS) is a 501(c)(3) non-profit research and educational organization that develops medical, legal, and cultural contexts for people to benefit from the careful uses of psychedelics and marijuana.https://maps.org/Dr Rick Doblin of MAPS podcastsRick Doblin: Psychedelics | Lex Fridman Podcast #202Joe Rogan Experience: Dr Rick Doblinhttps://open.spotify.com/episode/1Z8lzhvHCMv0c8qZWXbzzKMitchell, J.M., Bogenschutz, M., Lilienstein, A. et al.MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat Med27, 1025–1033 (2021). https://doi.org/10.1038/s41591-021-01336-3Selected ReferencesAyahuasca(1-9)Kambo (10-18)1.         Dos Santos RG, Valle M, Bouso JC, Nomdedéu JF, Rodríguez-Espinosa J, McIlhenny EH, et al. Autonomic, neuroendocrine, and immunological effects of ayahuasca: a comparative study with d-amphetamine. Journal of clinical psychopharmacology. 2011;31(6):717-26.2.         Hamill J, Hallak J, Dursun SM, Baker G. Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness. Curr Neuropharmacol. 2019;17(2):108-28.3.         Estrella-Parra EA, Almanza-Pérez JC, Alarcón-Aguilar FJ. Ayahuasca: Uses, Phytochemical and Biological Activities. Nat Prod Bioprospect. 2019;9(4):251-65.4.         Orsolini L, Chiappini S, Papanti D, Latini R, Volpe U, Fornaro M, et al. How does ayahuasca work from a psychiatric perspective? Pros and cons of the entheogenic therapy. Hum Psychopharmacol. 2020;35(3):e2728.5.         dos Santos RG. Immunological effects of ayahuasca in humans. J Psychoactive Drugs. 2014;46(5):383-8.6.         Zeifman RJ, Palhano-Fontes F, Hallak J, Arcoverde E, Maia-Oliveira JP, Araujo DB. The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial. Front Pharmacol. 2019;10:1325.7.         Dos Santos RG, Grasa E, Valle M, Ballester MR, Bouso JC, Nomdedéu JF, et al. Pharmacology of ayahuasca administered in two repeated doses. Psychopharmacology. 2012;219(4):1039-53.8.         Winkelman M. Psychedelics as medicines for substance abuse rehabilitation: evaluating treatments with LSD, Peyote, Ibogaine and Ayahuasca. Curr Drug Abuse Rev. 2014;7(2):101-16.9.         Palhano-Fontes F, Barreto D, Onias H, Andrade KC, Novaes MM, Pessoa JA, et al. Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychol Med. 2019;49(4):655-63.10.      Schmidt TT, Reiche S, Hage CLC, Bermpohl F, Majic T. Acute and subacute psychoactive effects of Kambo, the secretion of the Amazonian Giant Maki Frog (Phyllomedusa bicolor): retrospective reports. Sci Rep. 2020;10(1):21544.11.      Roy R, Baranwal A, Espiridion ED. Can Overuse of Kambo Cause Psychosis? Cureus. 2018;10(6):e2770.12.      Majic T, Sauter M, Bermpohl F, Schmidt TT. Connected to the spirit of the frog: An Internet-based survey on Kambo, the secretion of the Amazonian Giant Maki Frog (Phyllomedusa bicolor): Motivations for use, settings and subjective experiences. J Psychopharmacol. 2021;35(4):421-36.13.      Rali P, O'Corragain O, Oresanya L, Yu D, Sheriff O, Weiss R, et al. Incidence of venous thromboembolism in coronavirus disease 2019: An experience from a single large academic center. J Vasc Surg Venous Lymphat Disord. 2021;9(3):585-91 e2.14.      Byard RW. Is voluntary envenomation from the kambo ritual therapeutic or toxic? Forensic Sci Med Pathol. 2020;16(2):205-6.15.      Peleg Hasson S, Shachar E, Kessner R, Shpigel S, Wolf I. Kambo-Induced Systemic Inflammatory Response: A Case Report of Acute Disease Progression of Cholangiocarcinoma. Integr Cancer Ther. 2021;20:1534735421999106.16.      Junior VH, Martins IA. KAMBO: an Amazonian enigma. J Venom Res. 2020;10:13-7.17.      Silva F, Monteiro WM, Bernarde PS. "Kambo" frog (Phyllomedusa bicolor): use in folk medicine and potential health risks. Rev Soc Bras Med Trop. 2019;52:e20180467.18.      den Brave PS, Bruins E, Bronkhorst MW. Phyllomedusa bicolor skin secretion and the Kambo ritual. J Venom Anim Toxins Incl Trop Dis. 2014;20:40.

The Intelligence
It rains, it pours: Haiti's tragedy compounds

The Intelligence

Play Episode Listen Later Aug 17, 2021 20:03


A president's assassination, a cratered economy and now this: a tropical depression that will hamper rescue efforts after a massive earthquake. The country cannot catch a break. India and Pakistan parted ways 74 years ago this week; we discuss how the tensions that defined their division still resonate today. And why Indonesia is so good at badminton.For full access to print, digital and audio editions of The Economist, subscribe here www.economist.com/intelligenceoffer See acast.com/privacy for privacy and opt-out information.

Economist Radio
It rains, it pours: Haiti's tragedy compounds

Economist Radio

Play Episode Listen Later Aug 17, 2021 20:03


A president's assassination, a cratered economy and now this: a tropical depression that will hamper rescue efforts after a massive earthquake. The country cannot catch a break. India and Pakistan parted ways 74 years ago this week; we discuss how the tensions that defined their division still resonate today. And why Indonesia is so good at badminton.For full access to print, digital and audio editions of The Economist, subscribe here www.economist.com/intelligenceoffer See acast.com/privacy for privacy and opt-out information.

The Evan Brand Show
Dr. J and Evan on The Top 5 Nutrients and Compounds for Immune Support

The Evan Brand Show

Play Episode Listen Later Aug 17, 2021


With everything going on today our immune system needs all the support it can get - tune in as we talk about the top 5 nutrients and compounds for immune support. If you're looking for something to support your immune system, you can check out our Glutathione Pro: https://auraroots.com/products/glutathione-pro-60-c If you'd like our help clinically, you can reach out at evanbrand.com/free and we'll be happy to help you!

Biohacking Superhuman Performance
Episode 55: Dr. Sandy Kaufmann Longevity Expert – Sneak Peak at 3 New AntiAging Compounds That Have Earned a Spot in Her New Book

Biohacking Superhuman Performance

Play Episode Listen Later Aug 10, 2021 97:11


In this week's episode, Nathalie talks to Dr. Sandy Kaufmann the seven tenets of aging, 3 of the amazing compounds she has included in her upcoming new book and how to stay young as you get older!   Meet This Week's Guest Dr. Kaufmann began her academic career in the field of cellular biology, earning a Master's Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. For the last five years she has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children's Hospital, a nationally recognized center of excellence. Most recently, she was recognized as “Best in Medicine” by the American Health Council. Her avid interest in the science of anti-aging began many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first, ever, comprehensive theory of aging.   Episode Sponsor:  Oxford HealthSpan brings us Primeadine, the best formulated Spermidine supplement on the market!  What makes it stand out – it includes Spermine & Putrescine two other Polyamines that work hand in hand with Spermidine PLUS FOS, a prebiotic to feed the bacteria in your gut that make Spermidine!  I take Spermidine daily as do my family and my clients – it has become a solid member of my “foundation stack”.  Research has shown that Spermidine upregulates autophagy, helps the immune system to rejuvenate and it protects DNA – visible benefits experienced by myself and my clients include better sleep, hair, skin and nails!  If you haven't tried it yet go to Primeadine.com and use promo code BIONAT15 to save 15%.   Key Takeaways [03:40] About Dr. Kaufmann... [06:20] The seven tenets of aging: Information Systems (DNA), Cellular Energy, Cellular Pathways, Quality Control, Immune System, Individual Cells, Waste Management… [14:07] Should you do an aggressive heavy metal detox?.. [16:21] Should we all be taking prenatal vitamins?.. [19:28] The ranking system of the seven tenets of aging covered in the Kaufman Protocol [24:28] About the Kauffmann protocol app… [27:30] Should you stay on supplements indefinitely or cycle them?.. [28:35] What supplements are the foundational supplements most people should be on?.. [38:12] Thoughts on vitamin D3?.. [38:46] Teaser of Dr. Kaufmann's second book. How is the book organized? Can you use the book like a health encyclopedia?.. [42:00] Ecklonia cava, the key to weight loss, healthy skin and hair?.. [53:30] Reishi mushrooms, the key to immortality? [62:00] Spermidine, the one of a kind supplement that fills in all the gaps [74:00] What are the best brain supplements? [78:55] What are the best antiaging tips that do not involve supplements?   Linkage: Website: https://kaufmannprotocol.com/ Instagram: @Kaufmannantiaging     Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.    

CannaInsider - Interviews with the Business Leaders of The Legal Cannabis, Marijuana, CBD Industry
Ep 359 - Delta-8 THC and 5-MeO-DMT (Two Compounds You Need To Know About)

CannaInsider - Interviews with the Business Leaders of The Legal Cannabis, Marijuana, CBD Industry

Play Episode Listen Later Aug 9, 2021 54:20


What are Delta-8 THC and 5-MeO-DMT and what's all the hype about? Here to help us understand is the cannabis whisper himself, Max Montrose of Trichome Institute. Learn more at https://trichomeinstitute.com  Key Takeaways: [00:43] An inside look at Trichome Institute, the leading cannabis education company [2:06] Delta-8 THC and how it differs from its better-known cousin delta-9 THC [3:45] Why delta-8 is surging in popularity [13:36] Where Max sees delta-8 THC heading over the next 3-5 years  [16:44] Max's partnership with Abstrax, an industry leader in the study and production of cannabis and botanically-derived terpenes [23:39] 5-MeO-DMT, a psychedelic found in a variety of plant species and the glands of the Sonoran Desert toad [27:39] Max's work studying the Sonoran Desert toad and their unique venom glands [41:12] How Max's experiences with 5-MeO-DMT and ayahuasca have changed his philosophies and way of life

PeerView Internal Medicine CME/CNE/CPE Video Podcast
Nicola Gökbuget, MD - Achieving Therapeutic Innovation in ALL: Insights on Modern Asparaginase Compounds in Pediatric, AYA, and Adult Patients

PeerView Internal Medicine CME/CNE/CPE Video Podcast

Play Episode Listen Later Aug 6, 2021 83:31


Go online to PeerView.com/JPA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. This Clinical Consults activity features case-based expert discussions on the use of asparaginase in the context of broader innovations in ALL care across pediatric, AYA, and adult patients. Our experts give insights on standard asparaginase compounds, monitoring and management of toxicities, hypersensitivity/silent inactivation, and sequential use of alternative asparaginase compounds. Upon completion of this accredited CE activity, participants should be better able to: Cite current, multimodal recommendations for acute lymphoblastic leukemia (ALL) management in pediatric, adolescents and young adult (AYA), and adult populations, including multi-agent chemotherapy and asparaginase compounds, antibody-based approaches, cellular therapy, and tyrosine kinase inhibitors, Discuss the clinical implications of Escherichia coli (E. coli) asparaginase hypersensitivity and asparaginase discontinuation in ALL, including in pediatric, AYA, and adult populations, Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations as a component of chemotherapy for ALL, Apply updated protocols for the management of E. coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Oncology & Hematology CME/CNE/CPE Video Podcast
Nicola Gökbuget, MD - Achieving Therapeutic Innovation in ALL: Insights on Modern Asparaginase Compounds in Pediatric, AYA, and Adult Patients

PeerView Oncology & Hematology CME/CNE/CPE Video Podcast

Play Episode Listen Later Aug 6, 2021 83:31


Go online to PeerView.com/JPA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. This Clinical Consults activity features case-based expert discussions on the use of asparaginase in the context of broader innovations in ALL care across pediatric, AYA, and adult patients. Our experts give insights on standard asparaginase compounds, monitoring and management of toxicities, hypersensitivity/silent inactivation, and sequential use of alternative asparaginase compounds. Upon completion of this accredited CE activity, participants should be better able to: Cite current, multimodal recommendations for acute lymphoblastic leukemia (ALL) management in pediatric, adolescents and young adult (AYA), and adult populations, including multi-agent chemotherapy and asparaginase compounds, antibody-based approaches, cellular therapy, and tyrosine kinase inhibitors, Discuss the clinical implications of Escherichia coli (E. coli) asparaginase hypersensitivity and asparaginase discontinuation in ALL, including in pediatric, AYA, and adult populations, Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations as a component of chemotherapy for ALL, Apply updated protocols for the management of E. coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Heart, Lung & Blood CME/CNE/CPE Video Podcast
Nicola Gökbuget, MD - Achieving Therapeutic Innovation in ALL: Insights on Modern Asparaginase Compounds in Pediatric, AYA, and Adult Patients

PeerView Heart, Lung & Blood CME/CNE/CPE Video Podcast

Play Episode Listen Later Aug 6, 2021 83:31


Go online to PeerView.com/JPA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. This Clinical Consults activity features case-based expert discussions on the use of asparaginase in the context of broader innovations in ALL care across pediatric, AYA, and adult patients. Our experts give insights on standard asparaginase compounds, monitoring and management of toxicities, hypersensitivity/silent inactivation, and sequential use of alternative asparaginase compounds. Upon completion of this accredited CE activity, participants should be better able to: Cite current, multimodal recommendations for acute lymphoblastic leukemia (ALL) management in pediatric, adolescents and young adult (AYA), and adult populations, including multi-agent chemotherapy and asparaginase compounds, antibody-based approaches, cellular therapy, and tyrosine kinase inhibitors, Discuss the clinical implications of Escherichia coli (E. coli) asparaginase hypersensitivity and asparaginase discontinuation in ALL, including in pediatric, AYA, and adult populations, Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations as a component of chemotherapy for ALL, Apply updated protocols for the management of E. coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

The Melanie Avalon Biohacking Podcast
#105 - Glen Matten: The Sirtfood Diet, Beneficial Plant Compounds Antioxidants & Polyphenols, Coffee, Chocolate, & Wine, Hormetic Stress & Xenohormesis, Sirtuin Activation, And More!

The Melanie Avalon Biohacking Podcast

Play Episode Listen Later Aug 6, 2021 97:59


GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/sirtuins 2:45 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 3:05 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:30 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 4:00 - DRY FARM WINES: Low Sugar, Low Alcohol, Toxin-Free, Mold-Free, Pesticide-Free, Hang-Over Free Natural Wine! Use The Link dryfarmwines.com/melanieavalon To Get A Bottle For A Penny! 5:05 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At melanieavalon.com/cleanbeauty! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 10:25 - Glen Matten's Personal Story 12:00 - Antioxidants 14:40 - What Are The Beneficial Plant Compounds? 15:20 - Phytonutrients 20:45 - How We Benefit From Plant Foods 22:30 - Hormetic Stress 24:15 - Xenohormesis 25:35 - SUNLIGHTEN: Get $200 Off Any Sunlighten Cabin Model Or $100 Off The Solo Unit (That Melanie Has!) AND $99 Shipping (Regularly $598) With The Code MelanieAvalon At MelanieAvalon.Com/Sunlighten. Forward Your Proof Of Purchase To Podcast@MelanieAvalon.com, To Receive A Signed Copy Of What When Wine! 27:00 - The Carnivore Debate 29:45 - Olive Oil, Cocoa Flavonoids, Red Wine And Coffee 31:15 - Blue Zones 32:00 - Being A Dietary Agnostic 33:40 - Plants As Signaling Molecules 35:00 - What Are Sirtuins? 40:00 - What The 7 Sirtuins Are Responsible For 42:20 - The Connection Between Fasting And Sirtuin Activation 46:35 - Antioxidants While Fasting 48:45 - Sirtuin Activation 53:50 - The Difference Between Fasting And Sirtuin Activation 1:00:50 - The First 7 Days Of The Sirtfood Diet 1:05:10 - Gaining Muscle 1:07:50 - LUMEN: The Lumen Breath Analyzer That Tells Your Body If You're Burning Carbs Or Fat For Energy! Get $25 Off A Lumen Device At melanieavalon.com/lumen With The Code melanieavalon25! 1:10:15 - Leucine 1:12:45 -PI3 Kinase, AMPK, MTor 1:19:20 - Home Gardens 1:20:05 - Wine 1:24:25 - Dry Farming 1:25:05 - Chocolate & Cocoa Go To thegoodchocolatecompany.com And Use The Coupon Code MelanieAvalon For 10% Off! 1:32:00 - A Diet Of Inclusion

The Gary Null Show
The Gary Null Show - 08.03.21

The Gary Null Show

Play Episode Listen Later Aug 3, 2021 61:25


When stressed, people are quicker to jump to the worst conclusion University College London, July 29, 2021 When under stress, people reach undesirable conclusions based on weaker evidence than when they are relaxed, finds a new study led by UCL researchers. The findings, published today in the Journal of Neuroscience, show that stress can make people more likely to conclude the worst scenario is true. Senior author Professor Tali Sharot (UCL Psychology & Language Sciences and Max Planck UCL Centre for Computational Psychiatry and Ageing Research) said: "Many of the most significant choices you will make, from financial decisions to medical and professional ones, will happen while you feel stressed. Often these decisions require you to first gather information and weigh the evidence. For example, you may consult multiple physicians before deciding on a best course of medical treatment. We wanted to find out: does feeling stressed change how you process and use the information you gather? "Our research suggests that under stress, people weight each piece of evidence that supports undesirable conclusions more than when they are relaxed. In contrast, how they weigh evidence that supports desirable conclusions is not affected by stress. As a result, people are more likely to conclude the worst is true when they are stressed." For the study, 91 volunteers played a categorisation game, in which they could gather as much evidence as they wanted to decide whether they were in a desirable environment (which was associated with rewards) or an undesirable environment (which was associated with losses). They were incentivised for accuracy. Prior to playing the game, 40 of the volunteers were told that they had to give a surprise public speech, which would be judged by a panel of experts. This caused them to feel stressed and anxious. The researchers found that under stress, the volunteers needed weaker evidence to reach the conclusion that they were in the undesirable environment. By contrast, stress did not change the strength of the evidence needed to reach the conclusion that they were in the desirable environment. Lead author, PhD student Laura Globig (UCL Psychology & Language Sciences and Max Planck UCL Centre for Computational Psychiatry and Ageing Research) said that "we usually think of stressful situations as a hindrance to our decision-making process. But the pattern of learning we have uncovered may counterintuitively be adaptive, because negative beliefs may drive people to be extra cautious when in threatening environments."   Thai Cabinet Approves Use of Fah Talai Jone (green chiretta) to Treat Asymptomatic COVID-19 Cases Bangkok Post, July 22, 2021 Prime Minister Prayut Chan-o-cha has instructed authorities to set up a committee to study the use of green chiretta (Andrographis paniculata) extracts to treat Covid-19 patients with mild symptoms. The announcement was made at a cabinet meeting on Tuesday, which was convened to discuss additional measures to help curb the Covid-19 outbreak, the premier said on Wednesday. Deputy Prime Minister and Public Health Minister Anutin Charnvirakul was appointed head of the committee. It will coordinate studies on the safety and efficacy of green chiretta extracts on Covid-19 patients, as well as draft a strategic plan to promote Thai traditional medicine in general. The decision was taken in response to a proposal from Justice Minister Somsak Thepsutin, who urged the government to scale up the use of traditional medicines on Covid-19 patients with mild symptoms. This comes amid a vaccine shortage which has led to criticism for the government. His proposal came with evidence showing the Department of Corrections' success in treating 12,376 inmates who were infected with Covid-19 with green chiretta extracts. Of this number, 5,045 inmates were in Chiang Mai Central Prison, 2,100 in Nonthaburi Provincial Prison and 5,231 in Bang Kwang Central Prison also in Nonthaburi, said Mr Somsak. Before prescribing the herbal medicine to infected inmates, Mr Somsak said he had studied information by the Department of Thai Traditional and Alternative Medicine, which recommended a dosage of 180mg of andrographolides from green chiretta for five consecutive days to patients with mild symptoms. Citing the same research, the minister said each rai of land can yield up to 600kg of green chirettas, which can be turned into roughly 375,000 herbal extract capsules, he said. A total of 3.1 billion such capsules will be needed to cover all Thais, which means 8,400 rai of land will need to be planted with the herb, he said. The Department of Corrections now plans to produce about 50 million capsules of the herbal medicine in the next four months, which it aims to prescribe to about 50% of the prison population, he said. Due to its medical benefits, green chiretta has become a cash crop which is now in high demand in the export sector, he said. Mr Somsak added that the medicinal herb costs about 450 baht per kg    Taking breaks while learning improves memory   Max Planck Institute of Neurobiology (Germany), July 29, 2021 We remember things longer if we take breaks during learning, referred to as the spacing effect. Scientists at the Max Planck Institute of Neurobiology gained deeper insight into the neuronal basis for this phenomenon in mice. With longer intervals between learning repetitions, mice reuse more of the same neurons as before—instead of activating different ones. Possibly, this allows the neuronal connections to strengthen with each learning event, such that knowledge is stored for a longer time. Many of us have experienced the following: the day before an exam, we try to cram a huge amount of information into our brain. But just as quickly as we acquired it, the knowledge we have painstakingly gained is gone again. The good news is that we can counteract this forgetting. With expanded time intervals between individual learning events, we retain the knowledge for a longer time. But what happens in the brain during the spacing effect, and why is taking breaks so beneficial for our memory? It is generally thought that during learning, neurons are activated and form new connections. In this way, the learned knowledge is stored and can be retrieved by reactivating the same set of neurons. However, we still know very little about how pauses positively influence this process—even though the spacing effect was described more than a century ago and occurs in almost all animals. Learning in a maze Annet Glas and Pieter Goltstein, neurobiologists in the team of Mark Hübener and Tobias Bonhoeffer, investigated this phenomenon in mice. To do this, the animals had to remember the position of a hidden chocolate piece in a maze. On three consecutive opportunities, they were allowed to explore the maze and find their reward—including pauses of varying lengths. "Mice that were trained with the longer intervals between learning phases were not able to remember the position of the chocolate as quickly," explains Annet Glas. "But on the next day, the longer the pauses, the better was the mice's memory." During the maze test, the researchers additionally measured the activity of neurons in the prefrontal cortex. This brain region is of particular interest for learning processes, as it is known for its role in complex thinking tasks. Accordingly, the scientists showed that inactivation of the prefrontal cortex impaired the mice's performance in the maze. "If three learning phases follow each other very quickly, we intuitively expected the same neurons to be activated," Pieter Goltstein says. "After all, it is the same experiment with the same information. However, after a long break, it would be conceivable that the brain interprets the following learning phase as a new event and processes it with different neurons." However, the researchers found exactly the opposite when they compared the neuronal activity during different learning phases. After short pauses, the activation pattern in the brain fluctuated more than compared to long pauses: In fast successive learning phases, the mice activated mostly different neurons. When taking longer breaks, the same neurons active during the first learning phase were used again later. Memory benefits from longer breaks Reactivating the same neurons could allow the brain to strengthen the connections between these cells in each learning phase—there is no need to start from scratch and establish the contacts first. "That's why we believe that memory benefits from longer breaks," says Pieter Goltstein. Thus, after more than a century, the study provides the first insights into the neuronal processes that explain the positive effect of learning breaks. With spaced learning, we may reach our goal more slowly, but we benefit from our knowledge for much longer. Hopefully, we won't have forgotten this by the time we take our next exam!     The flavonoid epicatechin inhibits progressive tau pathology in Alzheimer's University of Bath (UK), July 23, 2021 According to news reporting originating in Avon, United Kingdom, by NewsRx journalists, research stated, “Aggregation of the microtubule-associated protein tau into paired helical filaments (PHFs) and neurofibrillary tangles is a defining characteristic of Alzheimer's Disease. Various plant polyphenols disrupt tau aggregation in vitro but display poor bioavailability and low potency, challenging their therapeutic translation.”  Green tea, cocoa, blackberries and blueberries are high in epicatechin. The news reporters obtained a quote from the research from the University of Bath, “We previously reported that oral administration of the flavonoid (-)-epicatechin (EC) reduced Amyloid-beta (A beta) plaque pathology in APP/PS1 transgenic mice. Here, we investigated whether EC impacts on tau pathology, independent of actions on A beta, using rTg4510 mice expressing P301L mutant tau. 4 and 6.5 months old rTg4510 mice received EC (similar to 18 mg/day) or vehicle (ethanol) via drinking water for 21 days and the levels of total and phosphorylated tau were assessed. At 4 months, tau appeared as two bands of similar to 55 kDa, phosphorylated at Ser262 and Ser396 and was unaffected by exposure to EC. At 6.5 months an additional higher molecular weight form of tau was detected at similar to 64 kDa which was phosphorylated at Ser262, Ser396 and additionally at the AT8 sites, indicative of the presence of PHFs. EC consumption reduced the levels of the similar to 64 kDa tau species and inhibited phosphorylation at Ser262 and AT8 phosphoepitopes. Regulation of the key tau kinase glycogen synthase kinase 3 beta (GSK3 beta) by phosphorylation at Ser9 was not altered by exposure to EC in mice or primary neurons. Furthermore, EC did not significantly inhibit GSK3 beta activity at physiologically-relevant concentrations in a cell free assay.” According to the news reporters, the research concluded: “Therefore, a 21-day intervention with EC inhibits or reverses the development of tau pathology in rTg4510 mice independently of direct inhibition of GSK3 beta.”     Fruit compound may have potential to prevent and treat Parkinson's disease   Johns Hopkins University, July 29, 2021 Johns Hopkins Medicine researchers say they have added to evidence that the compound farnesol, found naturally in herbs, and berries and other fruits, prevents and reverses brain damage linked to Parkinson's disease in mouse studies. he compound, used in flavorings and perfume-making, can prevent the loss of neurons that produce dopamine in the brains of mice by deactivating PARIS, a key proteininvolved in the disease's progression. Loss of such neurons affects movement and cognition, leading to hallmark symptoms of Parkinson's disease such as tremors, muscle rigidity, confusion and dementia. Farnesol's ability to block PARIS, say the researchers, could guide development of new Parkinson's disease interventions that specifically target this protein. "Our experiments showed that farnesol both significantly prevented the loss of dopamine neurons and reversed behavioral deficits in mice, indicating its promise as a potential drug treatment to prevent Parkinson's disease," says Ted Dawson, M.D., Ph.D., director of the Johns Hopkins Institute for Cell Engineering and professor of neurology at the Johns Hopkins University School of Medicine. Results of the new study, published July 28, in Science Translational Medicine, detail how the researchers identified farnesol's potential by screening a large library of drugs to find those that inhibited PARIS. In the brains of people with Parkinson's disease, a buildup of PARIS slows down the manufacture of the protective protein PGC-1alpha. The protein shields brain cells from damaging reactive oxygen molecules that accumulate in the brain. Without PGC-1alpha, dopamine neurons die off, leading to the cognitive and physical changes associated with Parkinson's disease. To study whether farnesol could protect brains from the effects of PARIS accumulation, the researchers fed mice either a farnesol-supplemented diet or a regular mouse diet for one week. Then, the researchers administered pre-formed fibrils of the protein alpha-synuclein, which is associated with the effects of Parkinson's disease in the brain. The researchers found that the mice fed the farnesol diet performed better on a strength and coordination test designed to detect advancement of Parkinson's disease symptoms. On average, the mice performed 100% better than mice injected with alpha-synuclein, but fed a regular diet. When the researchers later studied brain tissue of mice in the two groups, they found that the mice fed a farnesol-supplemented diet had twice as many healthy dopamine neurons than mice not fed the farnesol-enriched diet. The farnesol-fed mice also had approximately 55% more of the protective protein PGC-1alpha in their brains than the untreated mice. In chemical experiments, the researchers confirmed that farnesol binds to PARIS, changing the protein's shape so that it can no longer interfere with PGC-1alpha production. While farnesol is naturally produced, synthetic versions are used in commerce, and the amounts people get through diet is unclear. The researchers caution that safe doses of farnesol for humans have not yet been determined, and that only carefully controlled clinical trials can do so. Though more research is needed, Dawson and his team hope farnesol can someday be used to create treatments that prevent or reverse brain damage caused by Parkinson's disease.   Plant compounds reveal anticancer mechanisms Russian Academy of Sciences, July 28 2021.  Research published on June 9, 2021 in Scientific Reportsexplored mechanisms involved in the cancer protective effects of 30 compounds derived from fruits and vegetables. The researchers hope that their findings will contribute to the formulation of new drugs that will have fewer side effects than drugs currently in use.   “To create potent new drugs that will target only the tumor, it was necessary to determine how dietary compounds affect cell proteins in the prevention and treatment of cancer,” explained coauthor Grigory Zyryanov, who is a professor at the Russian Academy of Sciences. “Therefore, by modeling molecular mechanisms, we figured out how substances bind to proteins. This allowed us to determine the pool of therapeutic targets that the drugs will subsequently target. For example, these are anti-apoptotic (prevent apoptosis) and pro-apoptotic (induce apoptosis) proteins, protein kinases, and others. But a key drug target is phosphatidylinositol-3-kinase . . . This enzyme influences mutations in cancer, rearrangement, and amplification of genes.” Compounds investigated in the study included emodin, eugenol, gingerol, sulforaphane, linalool, catechin, oleanolic acid, ursolic acid, curcumin, yakuchinone-A, pinusolide, alpha-boswellic acid, oleandrin, sesquiterpene lactone-326, resveratrol, triterpenoid, beta-boswellic acid, anethole, capsaicin, glycolic acid, quercetin, genistein, ellagic acid, flavopiridol, zerumbone, garcinol, guggulsterone, parthenolide, halogenated monoterpenes and silibinin. Of these compounds, silibinin, flavopiridol, oleandrin, ursolic acid, alpha-boswellic acid, beta-boswellic acid, triterpenoid, guggulsterone and oleanolic acid had the greatest binding affinity with phosphatidylinositol-3-kinase alpha (P13K), which is involved in functions that can contribute to cancer. Other targets identified as binding with various compounds included PKC-η, Ras and H-Ras.  “We assumed that the foods we selected for the study had anti-cancer properties, but this needed to be verified,” Dr Zyryanov noted. “As a result, we found out that diseased cells stop development under the influence of certain combinations of food compounds.”     Meta-analysis supports potential of omega-3s for ADHD Kings College London, July 31, 2021 Omega-3s fatty acid supplements may improve symptoms and cognitive performance in children and adolescents with attention deficit hyperactivity disorder (ADHD), according to a meta-analysis of gold standard clinical trials. Data from seven clinical trials involving over 500 children and adolescents indicated that omega-3s were associated with improvements in clinical symptoms of ADHD, while data from three clinical trials involving over 200 children and adolescents indicated a positive impact on cognitive measures associated with attention. “[W]e provide strong evidence supporting a role for n3-PUFAs deficiency in ADHD, and for advocating n-3 PUFAs supplementation as a clinically relevant intervention in this group, especially if guided by a biomarker-based personalization approach,” wrote the authors, led by Jane Pei-Chen Chang from King's College London, in Neuropsychopharmacology . Boosting EPA/DHA intakes Commenting independently on the meta-analysis, Harry Rice, PhD, VP of regulatory & scientific affairs for the Global Organization for EPA and DHA Omega-3s (GOED): “In the past, I've been lukewarm on whether or not increasing EPA/DHA intake benefits children with ADHD. Results from this meta-analysis put me a little closer to believing. “Minimally, given the low side effect profile of omega-3s versus the drugs of choice to treat ADHD, I would highly recommend first increasing intake of EPA/DHA. This is particularly true if a child doesn't eat at least two servings of fatty fish a week or doesn't take an omega-3 supplement on a regular basis.” Meta-analysis details The new meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and used established scientific literature databases to identify appropriate studies for inclusion. Data from seven randomized controlled trials (RCTs) with 534 young people indicated that that omega-s3 supplementation significantly improved inattention and hyperactivity symptoms, according to parental reports. Additional analysis revealed that the improvements in hyperactivity were only observed when doses of EPA (eicosapentaenoic acid) of 500 mg/day or more were used. Interesting, the researchers did not find improvements in hyperactivity and inattention when they looked at teacher's reports, unlike what was reported by parents. Omega-3 supplements were associated with improvements in select measures of cognitive performance, said the researchers. “N-3 PUFAs are crucial for optimal neurotransmitter function: for example, incorporating more EPA and DHA in the cell membrane can increase cholesterol efflux, modulate lipid raft clustering and disruption, and affect the function of the dopamine transporter (DAT), which in turn may affect attention and executive function by regulating synaptic dopamine levels,” wrote the researchers. Omega-3 levels Data from case-control studies were also collected to assess if omega-3 levels were also associated with ADHD, with results indicating that children and adolescents with ADHD had lower levels of EPA, DHA (docosahexaenoic acid),and total omega-3s. “In the context of ‘personalised medicine', it is tempting to speculate that a subpopulation of youth with ADHD and with low levels of n-3 PUFAs may respond better to n-3 PUFAs supplementation, but there are no studies to date attempting this stratification approach,” wrote the researchers. “However, we have [previously] shown that individuals at genetic risk of developing depression in the context of the immune challenge, interferon-alpha (IFN-alpha), have lower levels of RBCs n3-PUFAs, and that n-3 PUFAs supplementation prevents the onset of IFN-alpha-induced depression, arguably by replenishing the endogenously low anti-inflammatory PUFAs in the ‘at risk' individuals.”

The Leadership Minute with Kevin DeShazo
The Leadership Minute - consistency compounds

The Leadership Minute with Kevin DeShazo

Play Episode Listen Later Jul 29, 2021 2:37


One good decision each day adds up --- Support this podcast: https://anchor.fm/kevindeshazo/support

Pints & Polishing...an Auto Detailing Podcast
Compounds, Customer Service w/ Detail Addicts

Pints & Polishing...an Auto Detailing Podcast

Play Episode Listen Later Jul 29, 2021 64:11


What does it take to launch a compound and polish? A couple years ago Josh decided to launch Detail Addicts with a great intent! In this episode, on the Community

Oncotarget
Oncotarget: Metal Compounds Induce DNA Instability In Cancer Cells

Oncotarget

Play Episode Listen Later Jul 22, 2021 5:16


Oncotarget's cover paper this week (Volume 12, Issue 15) is entitled, "Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells." About the Study: Researchers from the National Institutes of Health, University Paris-Saclay, Kazusa DNA Research Institute, and the University of Edinburgh used a dual-Human Artificial Chromosome (HAC) assay to analyze the genomic activity of six telomere-targeting platinum compounds. The dual-HAC assay was previously created by the researchers in this study to detect compounds that induce CIN through telomere dysfunction. This assay consists of two cell lines: one with telomeres, and one without. Disruption of the cell lines with telomeres denotes compound-induced CIN, and indicates potentially efficacious cancer therapeutics in vivo. “Recently we developed a dual-HAC-based assay allowing quantitative comparison of the efficiency and specificity of compounds to induce telomere dysfunction [36].” Pt-tpy, ​​a terpyridine platinum compound, and five of its structurally modified derivatives were assayed to determine their efficacy in creating genomic instability in cancer cells via telomere disruption. The team evaluated the six compounds using two isogenic human fibrosarcoma cell lines, the dual-HAC assay, FISH analysis of EGFP-HACs, telomere fluorescent in situ hybridization (Telo-FISH), flow cytometry, calculation of the rate of spontaneous HAC loss and after compound treatment, cell viability testing for measuring HAC loss in response to drug treatment, cytokinesis-block micronucleus assay, immunofluorescence, and statistical analysis. “We found that treatment of cancer cells with either Pt-cpym, Pt-vpym, Pt-ttpy or Pt-tpy induces telomere dysfunction leading to high levels of chromosome instability.” Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28020 DOI - https://doi.org/10.18632/oncotarget.28020 Full text - https://www.oncotarget.com/article/28020/text/ Correspondence to - Vladimir Larionov - larionov@mail.nih.gov and Natalay Kouprina - kouprinn@mail.nih.gov Keywords - chromosome instability, CIN, platinum-derived G4-quadruplexes, telomere dysfunction, human artificial chromosome About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget YouTube - https://www.youtube.com/c/OncotargetYouTube/ LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

THINK Business with Jon Dwoskin
Grow Your Business BIG: DAILY! - Make 1 More Call - It Compounds!

THINK Business with Jon Dwoskin

Play Episode Listen Later Jul 21, 2021 1:31


Jon shares how going that extra mile - making that 1 more call - can make a difference over time.   Connect with Jon Dwoskin: Twitter: @jdwoskin Facebook: https://www.facebook.com/jonathan.dwoskin Instagram: https://www.instagram.com/thejondwoskinexperience/ Website: https://jondwoskin.com/LinkedIn: https://www.linkedin.com/in/jondwoskin/ Email: jon@jondwoskin.com Get Jon's Book: The Think Big Movement: Grow your business big. Very Big!

PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast
Nicola Gökbuget, MD - Achieving Therapeutic Innovation in ALL: Insights on Modern Asparaginase Compounds in Pediatric, AYA, and Adult Patients

PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast

Play Episode Listen Later Jul 15, 2021 83:38


Go online to PeerView.com/JPA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. This Clinical Consults activity features case-based expert discussions on the use of asparaginase in the context of broader innovations in ALL care across pediatric, AYA, and adult patients. Our experts give insights on standard asparaginase compounds, monitoring and management of toxicities, hypersensitivity/silent inactivation, and sequential use of alternative asparaginase compounds. Upon completion of this accredited CE activity, participants should be better able to: Cite current, multimodal recommendations for acute lymphoblastic leukemia (ALL) management in pediatric, adolescents and young adult (AYA), and adult populations, including multi-agent chemotherapy and asparaginase compounds, antibody-based approaches, cellular therapy, and tyrosine kinase inhibitors, Discuss the clinical implications of Escherichia coli (E. coli) asparaginase hypersensitivity and asparaginase discontinuation in ALL, including in pediatric, AYA, and adult populations, Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations as a component of chemotherapy for ALL, Apply updated protocols for the management of E. coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Oncology & Hematology CME/CNE/CPE Audio Podcast
Nicola Gökbuget, MD - Achieving Therapeutic Innovation in ALL: Insights on Modern Asparaginase Compounds in Pediatric, AYA, and Adult Patients

PeerView Oncology & Hematology CME/CNE/CPE Audio Podcast

Play Episode Listen Later Jul 15, 2021 83:38


Go online to PeerView.com/JPA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. This Clinical Consults activity features case-based expert discussions on the use of asparaginase in the context of broader innovations in ALL care across pediatric, AYA, and adult patients. Our experts give insights on standard asparaginase compounds, monitoring and management of toxicities, hypersensitivity/silent inactivation, and sequential use of alternative asparaginase compounds. Upon completion of this accredited CE activity, participants should be better able to: Cite current, multimodal recommendations for acute lymphoblastic leukemia (ALL) management in pediatric, adolescents and young adult (AYA), and adult populations, including multi-agent chemotherapy and asparaginase compounds, antibody-based approaches, cellular therapy, and tyrosine kinase inhibitors, Discuss the clinical implications of Escherichia coli (E. coli) asparaginase hypersensitivity and asparaginase discontinuation in ALL, including in pediatric, AYA, and adult populations, Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations as a component of chemotherapy for ALL, Apply updated protocols for the management of E. coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Heart, Lung & Blood CME/CNE/CPE Audio Podcast
Nicola Gökbuget, MD - Achieving Therapeutic Innovation in ALL: Insights on Modern Asparaginase Compounds in Pediatric, AYA, and Adult Patients

PeerView Heart, Lung & Blood CME/CNE/CPE Audio Podcast

Play Episode Listen Later Jul 15, 2021 83:38


Go online to PeerView.com/JPA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. This Clinical Consults activity features case-based expert discussions on the use of asparaginase in the context of broader innovations in ALL care across pediatric, AYA, and adult patients. Our experts give insights on standard asparaginase compounds, monitoring and management of toxicities, hypersensitivity/silent inactivation, and sequential use of alternative asparaginase compounds. Upon completion of this accredited CE activity, participants should be better able to: Cite current, multimodal recommendations for acute lymphoblastic leukemia (ALL) management in pediatric, adolescents and young adult (AYA), and adult populations, including multi-agent chemotherapy and asparaginase compounds, antibody-based approaches, cellular therapy, and tyrosine kinase inhibitors, Discuss the clinical implications of Escherichia coli (E. coli) asparaginase hypersensitivity and asparaginase discontinuation in ALL, including in pediatric, AYA, and adult populations, Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations as a component of chemotherapy for ALL, Apply updated protocols for the management of E. coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Internal Medicine CME/CNE/CPE Audio Podcast
Nicola Gökbuget, MD - Achieving Therapeutic Innovation in ALL: Insights on Modern Asparaginase Compounds in Pediatric, AYA, and Adult Patients

PeerView Internal Medicine CME/CNE/CPE Audio Podcast

Play Episode Listen Later Jul 15, 2021 83:38


Go online to PeerView.com/JPA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. This Clinical Consults activity features case-based expert discussions on the use of asparaginase in the context of broader innovations in ALL care across pediatric, AYA, and adult patients. Our experts give insights on standard asparaginase compounds, monitoring and management of toxicities, hypersensitivity/silent inactivation, and sequential use of alternative asparaginase compounds. Upon completion of this accredited CE activity, participants should be better able to: Cite current, multimodal recommendations for acute lymphoblastic leukemia (ALL) management in pediatric, adolescents and young adult (AYA), and adult populations, including multi-agent chemotherapy and asparaginase compounds, antibody-based approaches, cellular therapy, and tyrosine kinase inhibitors, Discuss the clinical implications of Escherichia coli (E. coli) asparaginase hypersensitivity and asparaginase discontinuation in ALL, including in pediatric, AYA, and adult populations, Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations as a component of chemotherapy for ALL, Apply updated protocols for the management of E. coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

Pints & Polishing...an Auto Detailing Podcast
Resurrecting Compounds w/ Tommy From Angel Wax

Pints & Polishing...an Auto Detailing Podcast

Play Episode Listen Later Jul 1, 2021 96:48


Welcome to the Community

Evolutionary Radio
Evolutionary.org Podcast #402 - Cycles using four performance enhancing compounds

Evolutionary Radio

Play Episode Listen Later Jul 1, 2021 35:16


Evolutionary radio presents another exciting podcast. Host Stevesmi is joined by co-host Rick . Totally raw and unfiltered this time they discuss steroid cycle ideas. Cuadruple compound cycles for Cutting, Bulking and Recomp Newbie, intermediate and advanced. Should someone who is more advanced be using more potent compounds? listen to find out Which steroids fit these different categories? They debate which 4 compounds whether steroids, sarms, or anything else they recommend. discuss bulking cycles https://www.evolutionary.org/forums/anabolic-steroids-peds/best-bulking-cycle-9823.html Read an article about steroids 101 https://www.evolutionary.org/steroids-101/ Read an article about stacking steroids https://www.evolutionary.org/stacking-steroids-part-1/ Follow Ricky on Social: http://www.RickyVRock.com/ Follow Ricky and ask him anything: http://www.BigRickRock.com/ Check out the Evolutionary Radio Podcast: https://www.evolutionary.org/podcasts/ Check out the EliteFitness Podcast: https://www.elitefitness.com/articles/elitefitness-com-podcast-01-anavar-profile/

Maestros del Mezcal Podcast
Season 3 Episode 7 - Aromatic Compounds in Mezcal

Maestros del Mezcal Podcast

Play Episode Listen Later Jun 30, 2021 31:43


We talk with analytical chemist Adam Floyd about the mezcal samples he ran through Gas Chromatograph Mass Spectrometry

Modern Chemistry Podcast
Computing carbohydrates

Modern Chemistry Podcast

Play Episode Listen Later Jun 29, 2021 54:05


Elisa Fadda obtained her PhD in 2004 from the Department of Chemistry at the Université de Montréal under Professor Dennis R. Salahub. From May 2004 to May 2008, she worked as a post-doctoral fellow in Dr Régis Pomès group in Molecular Structure and Function at the Hospital for Sick Children (Sickkids) Research Institute in Toronto. From June 2008 until May 2013, Elisa worked as a research associate and honorary research lecturer in Prof Robert J. Woods group in the School of Chemistry at NUI Galway. In 2013 she was awarded a Post-Graduate Certificate in Teaching and Learning in Higher Education from the Centre for Learning and Teaching (CELT) at NUI Galway. In August 2013, Elisa became an Assistant Lecturer in the Department of Chemistry at Maynooth University, taking on a Lecturer position since 2014.You will hear the following terms used during the interview. I've included some descriptions here. Quantum chemistry -The branch of chemistry that apply quantum mechanics to chemical systems, including electronic structure, molecular dynamics and Schrödinger equations.Biophysics – And approach to science that applies methods typically used in physics to study biology and biological systems.Glycoproteins – Proteins which contain oligosaccharide chains (glycans), attached to amino acid side-chains via a covalent bond.Carbohydrates – Molecules (typically biological) composed of Carbon, Hydrogen and Oxygen, typically with a 2:1 Hydrogen:Oxygen atom ratio.Glycan (or polysaccharide) – Compounds made of many monosaccharide subunits, linked via a glycoside bond.N-Glycans – Glycans attached to a protein at an Asparagine residue via an N-glycosidic bond.Sequon – A sequence of amino acids in a protein that serve as a carbohydrate binding site.The carbohydrate is often an N-linked-Glycan.Asparagine, proline, serine, threonine. – Amino acids found naturally in biological proteins. Asparagine, serine and threonine are required in specific combinations to form a sequon, proline must be absent from a sequon.Glycosaminoglycans or mucopolysaccharides- Long, linear glucans consisting of repeating disaccharide units – most commonly uronic acid and an amino sugar.Glycosylation – A reaction in which a carbohydrate molecule is attached to a functional group of another molecule (such as a hydroxyl).  In biology the term typically refers to the carbohydrate being attached to a protein molecule.Folded protein – Proteins have several levels of structure, secondary, tertiary (and arguably quaternary) levels of structure describe how the polypeptide chain forms into specific structures that typically confer functional properties.Cryo-EM – Cryogenic Electron Microscopy studies samples cooled to cryogenic temperatures (-153 oC or lower), while embedded in vitreous water.X-Ray crystallography – A technique which uses X-rays to determine crystal structures, but studying the X-ray diffraction patterns.NMR – Nuclear Magnetic Resonance subjects samples to a strong magnetic fields and measures the resonance pattern of the nuclei. It is widely used to study the structure and dynamics of organic molecules.Spike proteins – More properly ‘Peplomers', spike proteins are glycoproteins that project from the surface of a virus particle lipid bilayer and play an important part in viral infectivity.Coronavirus – One of a group of related RNA viruses that cause respiratory tract infections in birds and mammals. These infections lead to diseases that can have mild effects, or be lethal. The Covid-19 pandemic was caused by a coronavirus, the SARS-CoV-2 virus. The 2002/4 SARS outbreak was caused by the SARS-CoV-1 virus.HIV – The Human Immunoseficiency Virus is two species of lentivirus that if left untreated cause Acquired Immunodeficiency Syndrome (AIDS) in humans.Receptor – A protein embedded in a cell membrane which binds to a specific molecule, or class of molecules.  Once the target molecule is bound, there is typically and effect within the cell to trigger some form of biological process.(viral) Pathogensis – The process by which a disease progresses. Viral pathogensis is specific to a disease caused by a virus.Computer node – Each computer in a connected cluster that are working together.GPUs – Graphics Processing Units are specific electronic circuits that rapidly address memory in order to output images to a display device. Their highly parallel structure makes them efficient at processing algorithms that process large data blocks in parallel.Glycoanalytics – Scientific study of glycosylated molecules, often biological in nature.Neuraminidase, or Sialidase – Are enzymes that cut the glycosidic bonds of neuraminic acids. This action helps viruses move through the respiratory tract mucus and infect host cells. The publication we refer to early on in the discussion is available at https://www.sciencedirect.com/science/article/pii/B9780128194751000560?via%3Dihub.  A full list of Elisa's publications is available at her group website. Elisa is contactable on social media, and you can find her on LinkedIn https://www.linkedin.com/in/elisa-fadda-a012b194/ (although, Elisa admits, she's rarely on LinkedIn)On Twitter, search @ElisaTelisaThe group website is https://efadda73.wixsite.com/elisafadda Our theme music is "Wholesome" by Kevin MacLeod (https://incompetech.com)Music from https://filmmusic.ioLicense: CC BY (http://creativecommons.org/licenses/by/4.0/) Connect with me (Paul) at https://www.linkedin.com/in/paulorange/H.E.L. group can be found at www.helgroup.com online,on LinkedIn at https://www.linkedin.com/company/hel-group/ on Twitter, we're @hel_group, https://twitter.com/hel_groupor search for us on Facebook

PeerView Oncology & Hematology CME/CNE/CPE Video Podcast
Elizabeth A. Raetz, MD / Rachel Rau, MD - Meeting Therapeutic Challenges in Pediatric ALL: Expert Perspectives on the Use of Asparaginase Compounds

PeerView Oncology & Hematology CME/CNE/CPE Video Podcast

Play Episode Listen Later Jun 22, 2021 61:12


Go online to PeerView.com/ZBG860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert faculty panel focuses on clinical decision-making related to the use of asparaginase compounds as part of pediatric acute lymphoblastic leukemia (ALL) therapy by pairing a sample case scenario with a short lecture designed to illustrate the tactics and techniques for addressing hypersensitivity and effectively utilizing available asparaginase options. Upon completion of this accredited CE activity, participants should be better able to: Describe the clinical implications of Escherichia coli asparaginase hypersensitivity and asparaginase discontinuation in pediatric acute lymphoblastic leukemia (ALL), Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations, as a component of multiagent chemotherapy for pediatric ALL, Develop protocols for the management of E coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Internal Medicine CME/CNE/CPE Video Podcast
Elizabeth A. Raetz, MD / Rachel Rau, MD - Meeting Therapeutic Challenges in Pediatric ALL: Expert Perspectives on the Use of Asparaginase Compounds

PeerView Internal Medicine CME/CNE/CPE Video Podcast

Play Episode Listen Later Jun 22, 2021 61:12


Go online to PeerView.com/ZBG860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert faculty panel focuses on clinical decision-making related to the use of asparaginase compounds as part of pediatric acute lymphoblastic leukemia (ALL) therapy by pairing a sample case scenario with a short lecture designed to illustrate the tactics and techniques for addressing hypersensitivity and effectively utilizing available asparaginase options. Upon completion of this accredited CE activity, participants should be better able to: Describe the clinical implications of Escherichia coli asparaginase hypersensitivity and asparaginase discontinuation in pediatric acute lymphoblastic leukemia (ALL), Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations, as a component of multiagent chemotherapy for pediatric ALL, Develop protocols for the management of E coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Oncology & Hematology CME/CNE/CPE Audio Podcast
Elizabeth A. Raetz, MD / Rachel Rau, MD - Meeting Therapeutic Challenges in Pediatric ALL: Expert Perspectives on the Use of Asparaginase Compounds

PeerView Oncology & Hematology CME/CNE/CPE Audio Podcast

Play Episode Listen Later Jun 22, 2021 61:09


Go online to PeerView.com/ZBG860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert faculty panel focuses on clinical decision-making related to the use of asparaginase compounds as part of pediatric acute lymphoblastic leukemia (ALL) therapy by pairing a sample case scenario with a short lecture designed to illustrate the tactics and techniques for addressing hypersensitivity and effectively utilizing available asparaginase options. Upon completion of this accredited CE activity, participants should be better able to: Describe the clinical implications of Escherichia coli asparaginase hypersensitivity and asparaginase discontinuation in pediatric acute lymphoblastic leukemia (ALL), Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations, as a component of multiagent chemotherapy for pediatric ALL, Develop protocols for the management of E coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Internal Medicine CME/CNE/CPE Audio Podcast
Elizabeth A. Raetz, MD / Rachel Rau, MD - Meeting Therapeutic Challenges in Pediatric ALL: Expert Perspectives on the Use of Asparaginase Compounds

PeerView Internal Medicine CME/CNE/CPE Audio Podcast

Play Episode Listen Later Jun 22, 2021 61:09


Go online to PeerView.com/ZBG860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert faculty panel focuses on clinical decision-making related to the use of asparaginase compounds as part of pediatric acute lymphoblastic leukemia (ALL) therapy by pairing a sample case scenario with a short lecture designed to illustrate the tactics and techniques for addressing hypersensitivity and effectively utilizing available asparaginase options. Upon completion of this accredited CE activity, participants should be better able to: Describe the clinical implications of Escherichia coli asparaginase hypersensitivity and asparaginase discontinuation in pediatric acute lymphoblastic leukemia (ALL), Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations, as a component of multiagent chemotherapy for pediatric ALL, Develop protocols for the management of E coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Heart, Lung & Blood CME/CNE/CPE Video Podcast
Elizabeth A. Raetz, MD / Rachel Rau, MD - Meeting Therapeutic Challenges in Pediatric ALL: Expert Perspectives on the Use of Asparaginase Compounds

PeerView Heart, Lung & Blood CME/CNE/CPE Video Podcast

Play Episode Listen Later Jun 22, 2021 61:12


Go online to PeerView.com/ZBG860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert faculty panel focuses on clinical decision-making related to the use of asparaginase compounds as part of pediatric acute lymphoblastic leukemia (ALL) therapy by pairing a sample case scenario with a short lecture designed to illustrate the tactics and techniques for addressing hypersensitivity and effectively utilizing available asparaginase options. Upon completion of this accredited CE activity, participants should be better able to: Describe the clinical implications of Escherichia coli asparaginase hypersensitivity and asparaginase discontinuation in pediatric acute lymphoblastic leukemia (ALL), Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations, as a component of multiagent chemotherapy for pediatric ALL, Develop protocols for the management of E coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast
Elizabeth A. Raetz, MD / Rachel Rau, MD - Meeting Therapeutic Challenges in Pediatric ALL: Expert Perspectives on the Use of Asparaginase Compounds

PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast

Play Episode Listen Later Jun 22, 2021 61:09


Go online to PeerView.com/ZBG860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert faculty panel focuses on clinical decision-making related to the use of asparaginase compounds as part of pediatric acute lymphoblastic leukemia (ALL) therapy by pairing a sample case scenario with a short lecture designed to illustrate the tactics and techniques for addressing hypersensitivity and effectively utilizing available asparaginase options. Upon completion of this accredited CE activity, participants should be better able to: Describe the clinical implications of Escherichia coli asparaginase hypersensitivity and asparaginase discontinuation in pediatric acute lymphoblastic leukemia (ALL), Summarize evidence surrounding the use of Erwinia chrysanthemi asparaginase, including recombinant formulations, as a component of multiagent chemotherapy for pediatric ALL, Develop protocols for the management of E coli asparaginase hypersensitivity, including monitoring and strategies for switching to Erwinia asparaginase options.

Empowering You Organically - Audio Edition
How to Do Detox Effectively

Empowering You Organically - Audio Edition

Play Episode Listen Later Jun 22, 2021 30:05


Your body is designed to remove toxins and waste on its own. But do you know how to support it? Tune in this week to learn how! We all have a Natural Detox Response. When we activate this response in our bodies, we increase our ability to protect your immune system naturally, and clear out the everyday toxins that find their way into your food, the air you breathe, the water you drink, and the surfaces you touch.   Natural Detox Response When we activate this response in our bodies we: Increase our ability to protect your immune system naturally clear out the everyday toxins that find their way into your food, the air you breathe, the water you drink, and the surfaces you touch Your body is designed to remove toxins and waste on its own. And while your organs are there to keep you alive, each and every one of them plays its own role in keeping you healthy. There are 4 organs more than any others that work together to create your personal detox machine working inside of you right now…   Your Liver acts like a filter in blocking out toxic substances in foods and drinks from passing into your bloodstream… Your Kidneys are working around the clock to then filter that blood and flush out those toxins when you use the bathroom. Your Colon puts in overtime taking care of the larger toxins and breaking them down with healthy bacteria before they can do you any harm… And Your Lungs play their part in filtering out the toxins that enter your body from breathing. As you can see, the human body was designed as a fully equipped detox machine.   How To Support Your ‘Detox Machine' You must take steps to support your body's Natural Detox Response System and I'm about to show you how right now… Once you begin to support your body's natural detox abilities, you'll notice that your body's “normal state” tends to shift toward health instead of inching toward illness. So what is it that your body needs to trigger your Natural Detox Response?   DETOX SUPPORT NUTRIENT #1 – Matcha   Matcha tea is the “it” health beverage of the moment, but this amazing superfood is more than just a “fad” trend. The history of matcha for health goes back to the Tang Dynasty in China, which ruled between the 7th – 10th centuries. Over time, the matcha tea made its way to Japan, where it began to be incorporated into special tea ceremonies. And today, countless scientific studies show us just how powerful this little nutrient is. First, it boosts chlorophyll levels. Chlorophyll can help improve liver function, which also boosts your body's ability to flush out toxins. So, it's no surprise that it's been shown to help with the excretion of heavy metals, dioxins, and other persistent chemicals, And the second part of the magic of matcha is big energy without the crash. Unlike the caffeine that comes from coffee beans, the caffeine in Matcha is released slowly into your system along with L-theanine, giving you a steady supply of energy so your body's natural detox system can function at its highest levels.   Other Benefits of Matcha: Protection against free radicals. You've heard about the antioxidant power of green tea, right? Well, matcha has 137 times more antioxidants than regular green tea! And 20 times more than a serving of blueberries. Antioxidants are key to disease prevention and are one of the best ways to boost your health. Cancer prevention. Catechins, which are potent cancer-fighters counteracting the effect of pollutants, chemicals, UV rays, and radiation, are a unique set of antioxidants found only in matcha. According to the National Cancer Institute, green tea is one of the most powerful cancer-fighters. Calm alertness. Matcha tea is rich in the amino acid L-Theanine, which is what left those Zen monks (and me) feeling calm, yet alert and focused. While it is a component of all green and black teas, matcha contains roughly five times the amount of L-theanine. Linked to increased concentration, learning ability and even physical endurance, L-Theanine gives you a boost without the caffeine jitters. (6) As someone who absolutely cannot handle the caffeine in coffee, matcha is my go to pick-me-up. If your clients or patients struggle with caffeine jitters, a cup of matcha might be a better choice. Anti-aging properties. A common drink in Okinawa, Japan, one of the few Blue Zones, where people live the longest, healthiest lives, matcha is said to reduce inflammation and oxidation, contributing to anti-aging. Fat-burning properties. One study found that matcha tea increased thermogenesis, the body's rate of burning calories, by about 4 times the normal rate. Another study showed that drinking matcha before exercise resulting in 25% more fat burning. Improving heart health. Green tea has been shown to lower LDL cholesterol, and lower incidence of heart disease and stroke in regular drinkers. (9) A recent Chinese study found that hypertension risk is lowered by up to 65 percent in regular green tea drinkers. Imagine the potential improvements to heart health in drinkers of the much more concentrated form of green tea that matcha is!   DETOX SUPPORT NUTRIENT #2 – Milk Thistle (Silybum marianum) Don't confuse this plant for a weed like most people do. It's a part of the artichoke family, a superfood known for its incredible support of the liver – your body's central detoxifier. In Germany, Milk Thistle is still prescribed today by doctors to treat alcoholic cirrhosis, hepatitis, jaundice, and any inflammation or poisoning of the liver.   Supports: Liver, Digestive Organs, and Lungs   DETOX SUPPORT NUTRIENT #3 – Blessed Thistle (Cnicus benedictus) Used for more than 2,000 years to stimulate appetite, support bile secretion, support liver health, this superfood is known for its support of your digestive system. Blessed thistle (Cnicus benedictus), not to be confused with milk thistle (Silybum marianum), was once used to treat the bubonic plague. It's still used today for natural digestive comfort and can even be applied to the skin to support wound healing.   Supports: Liver, Colon and Digestive System   DETOX SUPPORT NUTRIENT #4 – Licorice Root (Glycyrrhiza glabra) Licorice root is used to soothe gastrointestinal problems. In cases of food poisoning, stomach ulcers, and heartburn, licorice root extract can speed the repair of stomach lining and restore balance. This is due to the anti-inflammatory and immune-boosting properties of glycyrrhizic acid. Licorice is recommended to treat respiratory problems. Taking licorice as an oral supplement can help the body produce healthy mucus. Increasing phlegm production may seem counterintuitive to a healthy bronchial system. However, the opposite is true. The production of clean, healthy phlegm keeps the respiratory system functioning without old, sticky mucus clogging it.   Supports: Digestive System, Colon, Lungs   DETOX SUPPORT NUTRIENT #5 – Dandelion Root (Taraxacum officinale) You may be most familiar with dandelion as a stubborn weed that never seems to leave your lawn or garden. However, in traditional herbal medicine practices, dandelion are revered for their wide array of medicinal properties. For centuries, they've been used to treat a myriad of physical ailments, including cancer, acne, liver disease and digestive disorders. From root to flower, dandelion are highly nutritious plants, loaded with vitamins, minerals and fiber. Dandelion greens can be eaten cooked or raw and serve as an excellent source of vitamins A, C and K. They also contain vitamin E, folate and small amounts of other B vitamins. What's more, dandelion greens provide a substantial amount of several minerals, including iron, calcium, magnesium and potassium. The root of the dandelion is rich in the carbohydrate inulin, which is a type of soluble fiber found in plants that supports the growth and maintenance of a healthy bacterial flora in your intestinal tract. Dandelion are a rich source of beta-carotene and polyphenolic compounds, both of which are known to have strong antioxidant capabilities that can prevent aging and certain diseases. Animal studies have shown that dandelion protect liver tissue from toxic substances and oxidative stress. Some research indicates that dandelion may have antimicrobial and antiviral properties, which could support your body's ability to fight infection. Several test-tube studies found that dandelion extract significantly reduced the ability of viruses to replicate.   Supports: Colon, Liver, Digestive System   DETOX SUPPORT NUTRIENT #6 – Marshmallow Leaves (Althaea officinalis) Used by the ancient Greeks to remedy bruises and bleeding, and as a mild laxative. Europeans in medieval times used it for indigestion and diarrhea. And today it's still prescribed by doctors as a way to naturally soothe and support the intestines. Marshmallow leaves also have mild anti-infective and immune-supporting properties. That makes it perfect for gastroenteritis, peptic and duodenal ulcers, colitis, and enteritis.   Supports: Colon, Digestive System   Introducing: Organixx's NEW Organic Daily Detox Organic Daily Detox was designed specifically to boost your levels of these nutrients and feed your natural detox machine exactly what it needs to properly detox over the long run. The result? Better energy… Better sleep… Better ability to fight illness… And of course, a robust immune system you can depend on. Because Organixx is dedicated to the highest quality natural ingredients, a crystalized formula just made more sense. But there are other benefits as well. The first is potency. Most other detox “teas” just aren't made with enough quality ingredients to make any real difference to your health. They're watered down versions and are too weak to really do anything for you. The 2nd is freedom! With a traditional tea bag, you're forced to drink it as it is, with water. You're essential “bagged in” as I like to say and when your options are limited, you get bored quickly. But our specially formulated detox mix is perfect to be stirred into any of your other favorite drinks. It's made to mix easily so it's a perfect health boost in smoothies, juices or water. And because of the unique manufacturing process, any unneeded “filler” Liquids or compounds are extracted before it's turned into a crystalized format. It also makes Organic Daily Detox easier to drink. Simply take 1 or two scoops and drop it into hot or cold water. It mixes nearly instantly! Resources: Milk Thistle Benefits: 15 Ways This Super Herb Can Improve Your Health https://organixx.com/milk-thistle-benefits/?gl=60b8d78b8ebf583b0a3c207d Detox Your Liver Naturally! (+ 7 Tips for a Healthy Liver) https://organixx.com/liver-detox/?gl=60b8d78b8ebf58f1103c207f 11 Signs Your Body Is Screaming for a Detox https://www.foodmatters.com/article/the-importance-of-detoxifying-your-body Detoxification Pathways in the Liver http://link.springer.com/chapter/10.1007/978-94-011-9749-6_2 Chlorophyll and Chlorophyllin http://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/chlorophyll-chlorophyllin Determination of catechins in matcha green tea by micellar electrokinetic chromatography. https://www.ncbi.nlm.nih.gov/pubmed/14518774 Tea and Cancer Prevention https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/tea-fact-sheet Effect of Green Tea Phytochemicals on Mood and Cognition. https://www.ncbi.nlm.nih.gov/pubmed/28056735 Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women. https://www.ncbi.nlm.nih.gov/pubmed/24993695 Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials. https://www.ncbi.nlm.nih.gov/pubmed/21715508 Phytochemical Characterization of Low Molecular Weight Constituents from Marshmallow Roots (Althaea officinalis) and Inhibiting Effects of the Aqueous Extract on Human Hyaluronidase-1 https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.6b00670# Infections caused by Gram-positive bacteria: a review of the global challenge. https://www.ncbi.nlm.nih.gov/pubmed/19766888 Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders https://www.sciencedirect.com/science/article/pii/S0102695X14000477?via%3Dihub Aqueous extracts and polysaccharides from Marshmallow roots (Althea officinalis L.): Cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro https://www.sciencedirect.com/science/article/abs/pii/S0378874109006102?via%3Dihub Determination of Antioxidant Activity of Marshmallow Flower (Althaea officinalis L.) https://www.tandfonline.com/doi/abs/10.1081/AL-120039431 Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. https://www.ncbi.nlm.nih.gov/pubmed/19149749 Flavonoids--food sources and health benefits. https://www.ncbi.nlm.nih.gov/pubmed/25272572 Dietary, circulating beta-carotene and risk of all-cause mortality: a meta-analysis from prospective studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886629/ Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492638/ Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000725/ Natural forms of vitamin E: metabolism, antioxidant and anti-inflammatory activities and the role in disease prevention and therapy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120831/ Carotenoids, inflammation, and oxidative stress--implications of cellular signaling pathways and relation to chronic disease prevention. https://www.ncbi.nlm.nih.gov/pubmed/25134454 Flavonoids, Inflammation and Immune System https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084045/ Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. A randomized clinical pilot study. https://www.ncbi.nlm.nih.gov/pubmed/26367736 Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. https://www.ncbi.nlm.nih.gov/pubmed/2671116/ Hepatoprotective effect of silymarin. https://www.ncbi.nlm.nih.gov/pubmed/24672644 Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials. https://www.ncbi.nlm.nih.gov/pubmed/25208775 Characterisation of antimicrobial extracts from dandelion root (Taraxacum officinale) using LC-SPE-NMR. https://www.ncbi.nlm.nih.gov/pubmed/25644491 Isolation and Identification of Compounds from Bioactive Extracts of Taraxacum officinale Weber ex F. H. Wigg. (Dandelion) as a Potential Source of Antibacterial Agents. https://www.ncbi.nlm.nih.gov/pubmed/29507587 Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity. https://www.ncbi.nlm.nih.gov/pubmed/22078030 Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells. https://www.ncbi.nlm.nih.gov/pubmed/24481875 Leaves Antimicrobial Activity of Glycyrrhiza glabra L. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870067/ An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123991/ Antiviral Activity of Glycyrrhizin against Hepatitis C Virus In Vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715454/ 4 HUGE Matcha Green Tea Powder Benefits for Weight Loss, Detox & More! https://organixx.com/matcha-green-tea-powder/?gl=60b8d72e8ebf58f1103c207e Marshmallow: A Surprising Ingredient for Detox, the Gut, Respiratory Health & More https://organixx.com/marshmallow-plant-benefits/?gl=60b8d73a8ebf58f0103c207d

Bioprocess With The Bozenhardts
014: Dealing With The Nasties: BL-3, Potent Compounds, Solvents, & Peroxides

Bioprocess With The Bozenhardts

Play Episode Listen Later Jun 3, 2021 32:28


Herman & Erich Bozenhardt, PE are back, joining Louise Hall, PMP for a discussion on equipping your bioprocessing facilities to safely and efficiently handle the potent compounds, solvents, and peroxides used in the production of biologics. The trio discuss the adaptation of technologies and procedures to mitigate risk in the process of manufacturing exosomes, antibody drug conjugates, viral vectors, and more. 

Pints & Polishing...an Auto Detailing Podcast
Diminishing Abrasives & Water Based Compounds

Pints & Polishing...an Auto Detailing Podcast

Play Episode Listen Later Jun 3, 2021 74:43


How much time do you take during your compound stage? Could you save more time with a diminishing abrasive that also uses water based technology? Tonight on the Community

Struggle Creates Strength
MINDSET MONDAY - Consistency Compounds

Struggle Creates Strength

Play Episode Listen Later Jun 1, 2021 34:18


Consistency is not a once in a blue moon thing; it is constant action being taken at a certain level of performance over a quality of time. Constantly expanding with your work, studying, fitness, content, etc, will compound and lead to great success. Success is earned not given and through consistency you will obtain exactly what you desire. Being consistent is not always easy, but it sure is rewarding. There will be ups and downs, but if you persevere and continue to be consistent you will be rewarded by your actions. You don't lose 20lbs by going to gym once, you don't make a million dollar company by putting in one 12 hour day, and you don't become successful without consistency. The more consistent you are means the more successful you'll be because consistency compounds. * If you want to reach out to me or are interested in being on the podcast you can contact me via:   Instagram: Struggle Creates Strength Website: www.StruggleCreatesStrength.com Email: Info@StruggleCreatesStrength.ca Facebook: Struggle Creates Strength   Thanks so much for listening to another episode of Struggle Creates Strength and just remember that EVERYONE has a story.

MhChem Chemistry with Dr. Michael Russell
Chapter 19 Screencast - Nomenclature of Coordination Compounds

MhChem Chemistry with Dr. Michael Russell

Play Episode Listen Later May 24, 2021 8:19


A screencast from Chapter 19 in CH 223 which discusses the nomenclature system for coordination compounds in inorganic chemistry. https://mhchem.org/223/classroom/zAudio/Ch22aCoordNomen.mp4

The Melanie Avalon Biohacking Podcast
#093 - Shawn Wells: Quality Supplements, Berberine, Resveratrol, CBD, NMN, New Biohacking Compounds, Polyphenols & Adaptogens, Whole Foods Vs. Supplementation, Ketogenic Diets & Fasting, And More!

The Melanie Avalon Biohacking Podcast

Play Episode Listen Later May 14, 2021 118:41


GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/energyformula 2:00 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 2:10 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:40 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 3:15 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At melanieavalon.com/cleanbeauty! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 8:25 - Shawn's Beginnings 14:00 - Orthorexia 16:00 - The Role Of Fear In Health 21:40 - Being A Bio-Hacktivist 24:25 - The Relationship With Biohacking And Supplements 25:25 - Bad Supplements On The Market 27:35 - Is There Any Type Of Certification? 29:20 - FEALS: Feals Makes CBD Oil Which Satisfies ALL Of Melanie's Stringent Criteria - It's Premium, Full Spectrum, Organic, Tested, Pure CBD In MCT Oil! It's Delivered Directly To Your Doorstep. CBD Supports The Body's Natural Cannabinoid System, And Can Address An Array Of Issues, From Sleep To Stress To Chronic Pain, And More! Go To feals.com/melanieavalon To Become A Member And Get 50% Off Your First Order, With Free Shipping! 32:00 - How Are Vitamins And Supplements Made? 35:20 - What About Transdermal Patches? 38:15 - NMN Vs NR 38:00 - Intranasal Application 41:10 - Glutathione Supplementation 42:35 - L-Ergothioneine 44:10 - The Power Of Mushrooms 44:55 - Taking Exogenous Antioxidants; Vitamin C 47:00 - Polyphenols And Xenohormesis 49:40 - Whole Food Vs Supplements 53:20 - CBD 56:00 - Isolated Vs Full Spectrum CBD 57:00 - Powdered Processed Foods 59:20 - Whey Protein 1:00:30 - Collagen 1:02:20 - Importance Of Amino Acid Ratios 1:04:10 - Glycine 1:06:00 - What Is CD38? 1:08:20 - Berberine 1:10:30 - Berberine's Anti-Viral Properties 1:18:05 - SUNLIGHTEN: Get $200 Off Any Sunlighten Cabin Model Or $100 Off The Solo Unit (That Melanie Has!) AND $99 Shipping (Regularly $598) With The Code MelanieAvalon At melanieavalon.com/sunlighten. Forward Your Proof Of Purchase To Podcast@MelanieAvalon.com, To Receive A Signed Copy Of What When Wine! 1:19:20 - How Do You Know If Your Supplements Are Effective? 1:22:55 - Shawn's Top Picks 1:24:15 - Thoughts On Breaking A Fast 1:29:10 - Exogenous Ketones; RBHB Sodium 1:31:45 - MCTs 1:35:40 - BAIBA 1:37:45 - Anandamide 1:41:45 - Dehydrozingerone 1:45:10 - Nucleotides  1:46:10 - Tetrahydrocurcumin  1:50:00 - Raspberry Ketones

The Gary Null Show
The Gary Null Show - 05.07.21

The Gary Null Show

Play Episode Listen Later May 7, 2021 57:56


Higher omega-3 levels linked with lower risk of death during 16-year period The Fatty Acids and Outcomes Research Consortium, April 28 2021.    An analysis of prospective studies published on April 22, 2021 in Nature Communications uncovered a decreased risk of mortality during an average of 16 years among men and women who had higher red blood cell or plasma levels of omega-3 fatty acids.  The analysis was conducted by William S. Harris and The Fatty Acids and Outcomes Research Consortium (FORCE). Dr Harris is a codeveloper of the Omega-3 Index, which measures omega 3 levels in red blood cell membranes. The team examined 17 prospective studies that evaluated associations between the risk of death from all causes and levels of the omega-3 fatty acids alpha linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), and EPA plus DHA.  During the studies’ follow-up periods, 15,720 deaths occurred among a total of 42,466 men and women. Subjects whose EPA, DPA, DHA, and EPA plus DHA levels were among the top 10% of participants experienced a 9% to 13% reduction in mortality from all causes during follow-up compared to men and women whose levels were among the lowest 10%. When cause-specific mortality was examined, having EPA, DPA, DHA, or EPA plus DHA levels among the highest 10% was associated with a lower risk of cardiovascular mortality, cancer mortality and mortality from all other causes combined (with the exception of the association between DHA and reduced cancer mortality, which was not considered significant).  "Since all of these analyses were statistically adjusted for multiple personal and medical factors (i.e., age, sex, weight, smoking, diabetes, blood pressure, etc., plus blood omega-6 fatty acid levels), we believe that these are the strongest data published to date supporting the view that over the long-term, having higher blood omega-3 levels can help maintain better overall health," Dr Harris concluded.     New study shows tree nuts may play a role in both weight loss and weight maintenance   University of California at Los Angeles, May 4, 2021  In a randomized, controlled study* published online in the journal, Nutrients, researchers found that including mixed tree nuts in a weight management program resulted in significant weight loss and improved satiety. Researchers at UCLA compared 95 overweight/obese men and women (BMI 27.0-35.0 kg/m2) ages 30-68 years who consumed either 1.5 ounces of mixed tree nuts or a pretzel snack. Both snacks provided the same number of calories, as part of a hypocaloric weight loss diet (500 calories less than resting metabolic rate) over 12 weeks. This was followed by an isocaloric weight maintenance program for an additional 12 weeks.  Participants experienced significant weight loss (12 weeks: -1.6 kg and -1.9 kg and 24 weeks: -1.5 kg and -1.4 kg) in the tree nut and pretzel snack groups, respectively. Both groups also showed a significant decrease in BMI at 12 weeks, compared to baseline. However, satiety was significantly higher at the end of week 24 in the mixed tree nut group, and there was a trend toward greater weight maintenance compared to the pretzel group. Moreover, the dropout rate was significantly lower in the mixed tree nut group (16.4%) compared to the pretzel (35.9%) group. And, heart rate was decreased significantly, compared to baseline, in those consuming tree nuts, but not pretzels.  "Tree nuts (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts) are a great source of protein, healthy fats and fiber," explained lead researcher, Zhaoping Li, MD, PhD, Professor of Medicine and Chief of the Division of Clinical Nutrition at UCLA. "This makes them so satiating and may be a major reason why we saw less weight gain in the tree nut group during weight maintenance, and a significantly lower dropout rate compared to the pretzel group."  Recent research has shown that more than 40 percent of Americans are overweight or obese.** During the past year many Americans have gained weight while sheltering in place, partly due to less exercise and more snacking. One study estimates a weight gain of 1.5 pounds per month.*** "We know most people get about 25% of their calories each day from snacks and a large proportion come from desserts, sugar-sweetened beverages, sweets and salty snacks," states Dr. Li. "By replacing just one of those snacks with 1.5 ounces of tree nuts may result in a positive impact on weight and overall health." According to Maureen Ternus, M.S., R.D.N, Executive Director of the International Tree Nut Council Nutrition Research & Education Foundation (INC NREF), "This latest study adds to a growing body of evidence showing that nut consumption may be a useful tool in weight management."     Green tea compound and coconut oil may help improve depression in multiple sclerosis patients Catholic University of Valencia (Spain), April 30. 2021   According to news reporting originating from Valencia, Spain, research stated, “Multiple sclerosis (MS) is pathogenically characterized by high oxidative stress and symptomatically by progressive muscle loss and increased body fat associated with the presence of depression. Epigallocatechin gallate (EGCG) (particularly present in green tea) and ketone bodies (in particular beta-hydroxybutyrate (BHB)), whose main source is coconut oil, have shown emotional benefits and body fat loss.” The news journalists obtained a quote from the research from Catholic University of Valencia: “The aim of this study was to assess the impact of EGCG and coconut oil on cortisol activity related to fat loss and depression in MS patients. The study involved 51 MS patients who were randomly divided into an intervention group or a control group. The intervention group received 800 mg of EGCG and 60 mL of coconut oil, which were included in their daily diet for four months. The control group received placebo and all patients followed an isocaloric diet. A blood sample was collected before and after the four-month period, and levels of cortisol, albumin and BHB were measured in serum. In addition, immediately before and after the intervention, anthropometric variables were measured: waist-to-hip ratio (WHR), body fat mass percentage, fat weight, total weight, and muscle mass percentage. Depression was assessed with the Beck Depression Inventory II (BDI-II). No significant changes were obtained in cortisol levels in any of the groups, and there was a significant increase in albumin in the blood of the intervention group only that could lead to a decrease in serum free cortisol. In addition, it was observed a significant decrease in levels of depression and abdominal fat.” According to the news reporters, the research concluded: “EGCG combined with coconut oil increase the concentration of albumin in blood and produce less depression in MS patients.”       Vulnerable older people at greater risk of depression and anxiety during pandemic   University of Manchester (UK), May 5, 2021 Older people who are clinically vulnerable to COVID-19 are at greater risk of deterioration in health and social well-being during the pandemic, according to a new study. The research, published in the Journal of Epidemiology and Community Health, found that older people were more likely to report worse health outcomes than those with no clinical vulnerabilities, including greater depression and anxiety and lower quality of life, even when taking into account pre-pandemic levels of health and social well-being. The findings highlight the need for policymakers to consider the mental and physical health consequences of the pandemic for those at higher risk from coronavirus, particularly for those asked to shield. Professor Debora Price from The University of Manchester and Dr. Giorgio Di Gessa from UCL compared data from 2020's English Longitudinal Study of Aging with data from the previous year. They analyzed responses from over 5000 people aged 52 and over in private households in England. The study revealed that during the pandemic, respondents classified as clinically vulnerable were more likely to report poor self-rated health, lower levels of physical activity, depression, anxiety, lower quality of life as well as loneliness and receipt of care, compared to those without clinical vulnerabilities. This was true within each age group. Among people in their 70s, the odds of being depressed and anxious for those clinically vulnerable were around 50% higher than for those without clinical vulnerabilities. Those in their 80s—regardless of clinical vulnerability—were much more likely to have unmet care needs and to have little contact with friends and family by text, email, or videocall. Although older adults' health and social well-being have been impacted by shielding, the researchers found that it was those who were clinically vulnerable and shielding who reported the most substantial rises in anxiety, depression, poor self-rated health and receipt of formal care, as well as decreases in well-being and physical activity. "Older people with underlying health conditions, even before the pandemic, faced challenges in terms of access to healthcare services and social contact," said Professor Debora Price. "They also experienced greater emotional distress, higher risk of loneliness and poorer quality of life than non-vulnerable individuals." "While policies focusing on shielding clinically vulnerable older people reduce rates of hospitalization and death from COVID-19, policymakers need to acknowledge that there may be adverse consequences of this measure and address the wider needs of these vulnerable groups," added Dr. Giorgio Di Gessa. "It's vital that policymakers are aware that when advised to stay at home, a host of health and social risks for this group, already poor, are likely to be exacerbated."   Researchers find obesity linked to reduced blood flow to the brain Trinity College Dublin (Ireland), May 5, 2021 A new study from scientists at The Irish Longitudinal Study on Aging (TILDA) at Trinity College Dublin reveals important findings, indicating that being overweight or obese significantly reduces blood flow in the brain. The study also shows that increased physical activity can positively modify, or even negate, this reduction in brain blood flow. The study contains relevant information which is of great interest to the general public; since reduced blood flow in the brain, or 'cerebral hypoperfusion," is an early mechanism in vascular dementia and Alzheimer's disease. Obesity and health challenges According to the World Health Organization (WHO), obesity is a worsening health crisis that has reached epidemic proportions globally, with over 1 billion adults overweight—and at least 300 million clinically obese. It continues to be a major contributor to global rates of chronic disease and disability, affecting overall quality of life, while placing increased strain on the immune system which is of the upmost importance given the current COVID-19 situation. Obesity is also a significant public health concern given its negative impact on physiological function, especially as we age. Finding easily implemented and cost-effective ways to tackle the impact of obesity is particularly important to help protect against negative health outcomes in later life. What are the findings of the TILDA study? The study investigates three different measures of obesity—body mass index (BMI), waist-to-hip ratio and waist circumference, as well as physical activity, in adults over 50 years. Brain blood flow was measured using cutting-edge MRI scanning and analysis techniques. The findings reveal that being overweight or obese is associated with reduced blood supply to the brain. Whereas brain blood flow is known to decline with age, in this study the negative influence of obesity on brain blood flow was shown to be greater than that of age. However, being physically active helps to cancel out the negative effects of obesity on brain blood flow. Key Findings ncreased BMI, waist-to-hip ratio, and waist size are associated with less blood supply to the brain. A waist size increase of +1cm is associated with the same reduction in brain blood flow as +1 year of age. Higher levels of physical activity modify the associations between reduced brain blood flow and obesity. Recommendations The study recommends at least 1.5 to two hours of 'being active' throughout the day, engaging in activities that require moderate effort. These include activities that cause one to breathe harder than normal, such as fast walking or cycling. However, any increase in physical activity, particularly if integrated into daily or weekly habits, such as gardening, should help maintain and potentially improve brain blood flow. Dr. Silvin Knight, Research Fellow at TILDA and lead author, said: Consistent, healthy blood supply to the brain is critical, as it ensures that the brain is provided with enough oxygen and nutrients to function correctly. If brain blood flow becomes impaired, it can lead to serious health issues as we age, such as increasing the risk of dementia and Alzheimer's disease. We know that obesity can predispose a person to age-related conditions, illness, and disease, and even reduce life expectancy by up to six years in men and seven years in women, after the age of forty. Our study reveals clear associations between obesity and reduced blood supply to the brain in an older population. The study also shows the importance of being physically active for older overweight or obese individuals, as this may help to protect against reduced brain blood flow and the poor health outcomes that can arise from this. Professor Rose Anne Kenny, Principal Investigator of TILDA, and co-author of the study, said: "Many experts have shown that obesity and aging have very similar effects on the biology of aging; diseases associated with obesity are similar to those of aging and age-related diseases—heart disease, diabetes, high blood pressure, kidney failure, arthritis, susceptibility to infections- including COVID-19." Our study not only shows that there is a link between obesity and reduced brainblood flow, but also that it is possible to protect against the negative consequences of obesity through regular physical exercise. Whereas these findings are of relevance in the global context, because of the rapidly evolving global burden of obesity, the research is especially important to Irish adults because obesity and being overweight is a considerable health issue in Ireland. Previous TILDA research has shown that over one-third of Irish adults aged 50 and older are obese and a further 43% overweight. As we prepare our society for a growing aging population, we can use this evidence to prepare meaningful public health policies that will promote impactful and positive lifestyle habits, such as regular physical activity, to mitigate against some of the negative consequences of the growing obesity crisis.           In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, May 2, 2021 Objective In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus (2019-nCoV), an ongoing novel coronavirus that causes pneumonia. Methods There were two main steps in the screening process. In the first step we conducted a literature search for natural compounds that had been biologically confirmed as against sever acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus. Resulting compounds were cross-checked for listing in the Traditional Chinese Medicine Systems Pharmacology Database. Compounds meeting both requirements were subjected to absorption, distribution, metabolism and excretion (ADME) evaluation to verify that oral administration would be effective. Next, a docking analysis was used to test whether the compound had the potential for direct 2019-nCoV protein interaction. In the second step we searched Chinese herbal databases to identify plants containing the selected compounds. Plants containing 2 or more of the compounds identified in our screen were then checked against the catalogue for classic herbal usage. Finally, network pharmacology analysis was used to predict the general in vivo effects of each selected herb. Results Of the natural compounds screened, 13 that exist in traditional Chinese medicines were also found to have potential anti-2019-nCoV activity. Further, 125 Chinese herbs were found to contain 2 or more of these 13 compounds. Of these 125 herbs, 26 are classically catalogued as treating viral respiratory infections. Network pharmacology analysis predicted that the general in vivo roles of these 26 herbal plants were related to regulating viral infection, immune/inflammation reactions and hypoxia response. Conclusion Of course, it should be pointed out that Chinese herbs that have not been identified through this screening process may still have beneficial effects. Further, considering that the biologically validated natural compounds reported in the literature cannot cover all antiviral natural compounds, and the natural compounds included in the Chinese medicine database are not complete, the process that we have followed may have excluded herbs that would be well suited to this treatment. Nevertheless, the purpose of this screening was to provide a rational approach for selecting Chinese herbal medicines with a high potential efficacy in treating 2019-nCoV and related viruses. The specific dosage and usage of each herb should be determined based on patients’ manifestations. Finally, the key step in this screening was molecular docking. The 3D structures of the proteins used here are based on reported gene sequences. If the virus mutates during transmission, a new screening is recommended. In conclusion, this work has identified several Chinese medicinal plants classified as antiviral/pneumonia-effective that might directly inhibit the novel coronavirus, 2019-nCoV. Additionally, we propose screening principles and methods which may provide guidance in screening antiviral drugs from other natural drug databases.     Ginkgolide B monotherapy reverses osteoporosis by regulating oxidative stress-mediated bone homeostasis   Chinese University of Hong Kong, May 4, 2021 According to news reporting from Hong Kong, People’s Republic of China, research stated, “Osteoporosis is characterized by reductions in bone mass, which could be attributed to the dysregulation of bone homeostasis, such as the loss of balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Elevated levels of oxidative stress increase bone resorption by promoting osteoclastogenesis and inhibiting the osteogenesis.” The news correspondents obtained a quote from the research from the Chinese University of Hong Kong, “Ginkgolide B (GB), a small natural molecule from Ginkgo biloba, has been reported to possess pharmacological activities by regulating reactive oxygen species (ROS) in aging-related degenerative diseases. Herein, we assessed the therapeutic effects of GB on the bone phenotypes of mice with osteoporosis induced by (I) aging, (II) ovariectomy, and (III) glucocorticoids. In all three animal models, oral gavage of GB significantly improved bone mass consistent with the increase in the OPG-to-RANKL ratio. In the in vitro experiments, GB promoted osteogenesis in aged mesenchymal stem cells (MSCs) and repressed osteoclastogenesis in aged macrophages by reducing ROS. The serum protein profile in GB-treated aged mice revealed moderate rejuvenating effects; signaling pathways associated with ROS were also regulated. The anabolic and anti-catabolic effects of GB were illustrated by the reduction in ROS. Our results indicate that GB is effective in treating osteoporosis.” According to the news reporters, the research concluded: “The use of GB in patients with osteoporosis is worthy of further clinical investigation.” This research has been peer-reviewed.

Psychedelics Today
PTSF57 - New Compounds, Psychedelic Business, and Neurogenesis

Psychedelics Today

Play Episode Listen Later Apr 30, 2021 60:20


In this week's Solidarity Fridays episode, a power outage keeps Michelle from joining in, but Joe and Kyle pick up the slack, going old-school SF style for the week.  They talk about new drugs: Cybin investigating using their proprietary psychedelic compound "CYB003" for alcohol use disorder, and scientists using a technology called psychLight to identify when a compound activates the brain's serotonin 2A receptor (in hopes of activating the biological benefits of psychedelics without their traditional hallucinogenic effects). They also give a legalization update, with new cannabis and psychedelic reform bills in Texas and legalization bills in Louisiana, talk about non-profit Porta Sophia's new Psychedelic Prior Art Library and the importance of establishing a public domain, and discuss Johns Hopkins' new study on psilocybin for Alzheimer's-related depression (and ways to possibly combat the effects of Alzheimer's). They also cover climate change, Leonard Pickard, the tragedy of the commons, 2C-B, the importance of looking at fringe cases, and the intelligence of millennials.  Notable Quotes “How could we shift to more cooperative actions vs. competition all the time?” -Kyle “Our map of reality is minimized inappropriately when we exclude these fringe cases. ...What does it mean that somebody can present as psychic, or present as a spirit, or meet these spirits, or go to the [afterlife] and come back (in your case) and then get set on an interesting trajectory via psychedelics? This is not what doctors can deal with, but this is what those of us outside of medicine can deal with, as a philosophical endeavor.” -Joe “Some of these new compounds- I guess it’s exciting, and you always say we need new drugs, but …why is there a race for new drugs when we’re not even using the ones to the full potential that are not even on the market right now? ..Just thinking about all the new companies coming online trying to find new drugs for patents and development, when it’s like, have we really explored the potential of the ones that have been around for a while?” -Kyle  Links Psychedelics Today: Mind Bending, Mind Mending - A Series Exploring How Psychedelics Affect the Brain: Serotonergic Psychedelics Businesswire.com: Cybin Selects Alcohol Use Disorder Indication for Psychedelic Molecule CYB003 Johns Hopkins’ study on psilocybin for Alzheimer’s-related depression Reversing Alzheimer's: How to Prevent Dementia and Revitalize Your Brain, by Timothy J. Smith, MD Nypost.com: Ayahuasca tea could be a breakthrough treatment for Alzheimer’s The Tim Ferriss Show: Dr. Adam Gazzaley, UCSF - Brain Optimization and the Future of Psychedelic Medicine (#507) Neuroscape’s “Neuroracer” game Portasophia.org (Psychedelic Prior Art Library) Wikipedia.org: Tragedy of the commons Psychedelic Salon: Podcast 667 - “A Conversation with Leonard Pickard” The Rose Of Paracelsus: On Secrets & Sacraments, by William Leonard Pickard Saving Normal: An Insider's Revolt Against Out-Of-Control Psychiatric Diagnosis, Dsm-5, Big Pharma, and the Medicalization of Ordinar, by Allen Frances, M.D. Bluelight.org forums Marijuanamoment.net: Texas Lawmakers Approve Marijuana And Psychedelics Reform Bills Diaspora Psychedelic Society Marijuanamoment.net: Louisiana Lawmakers Approve Marijuana Legalization Bill In Committee Nypost.com: American faces years in Dubai prison after pot found in urine Scitechdaily.com: Scientists Discover a Psychedelic-Like Drug Without the Hallucinogenic Side Effects Support the show! Patreon Leave us a review on Facebook or iTunes Share us with your friends Join our Facebook group - Psychedelics Today group – Find the others and create community. Navigating Psychedelics

Talking Biotech Podcast
286 – Identifying Rare Compounds with A.I.

Talking Biotech Podcast

Play Episode Listen Later Apr 3, 2021 50:19


While genomics approaches have opened a universe of new compounds in plants, the vast majority remain uncharacterized. Brightseed has employed an artificial intelligence platform to scan for novel compounds, with a goal to identify new [...] The post 286 – Identifying Rare Compounds with A.I. first appeared on Talking Biotech Podcast.

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

Dr. Jack Schultz is a Professor in Plant Sciences and Director of the Bond Life Sciences Center at the University of Missouri. Jack is interested in understanding why insects and other animals don't consume all of the plants in the world. In his research, Jack has examined chemical defenses of plants and also chemical signaling in plants that can be detected by the predators that eat the insects that eat plants. Jack loves learning, so it's not always easy to pull himself away from the science. However, for most of his life, he has been an avid guitarist and really enjoyed playing music professionally and for fun. Jack also enjoys photography and landscape gardening. He received his PhD in Zoology from the University of Washington and completed postdoctoral research at Dartmouth College. He was then hired at Dartmouth as a Research Assistant Professor. Jack's next career move brought him to Penn State University where he remained for 25 years, rising to the rank of Distinguished Professor of Entomology before joining the faculty at the University of Missouri. Jack's research has been featured by the New York Times, People Magazine, and Time Magazine. Jack is here with us today to tell us all about his journey through life and science.

Ben Greenfield Fitness
Fringe Supplement Stacks You've Never Heard Of, The Best Nootropic Combinations, The Latest Keto Support Compounds, Supplements That Act Like "Exercise In A Bottle" & Much More With Shawn Wells

Ben Greenfield Fitness

Play Episode Listen Later Feb 25, 2021 81:30


bengreenfieldfitness.com/energyformula If there's anything people say they want more of these days...it's energy. The world around us continually requires more from us while we give less and less thought to our long-term health. This distracted and overwhelmed mindset has landed us squarely in survival mode, depriving us of the necessary steps to create lasting, sustained energy. The truth is most of us are so exhausted and don't know how to find the energy to live our best lives. My friend Shawn Wells just put the finishing touches on his new book The ENERGY Formula: Six Life Changing Ingredients to Unleash Your Limitless Potential... ...which covers keto, Paleo, biohacking, stoicism, supplements, CBD, nootropics, MCTs, infrared saunas, cold plunges, how to create a sleep fortress, circadian rhythm, and much more. With about 60 full-color diagrams and over 100 scientific citations, Shawn gives you the knowledge you will not find anywhere else, including "Formulator's Corners" in every chapter that cover doses, brands, and forms of supplements you need to be taking as well as "Resource Hacks" that tell you the products, devices, apps, and more to use. Developed by biochemist, dietitian, sports nutritionist, and formulation scientist Shawn Wells after surviving a series of torturous health battles, this pivotal and groundbreaking book is the product of meticulous and persistent research to find solutions to his personal and painful experiences—paired with two decades of legitimate clinical and scientific expertise. Shawn previously joined me on the podcast episode "The Nitty-Gritty Underground World of Supplement Ingredients, Sports Nutrition Frankenfuels, Illegally Laced Compounds & More.," and he's been studying up on plenty more since that show, so prepare for a wild ride on today's podcast. Shawn, who is an MPH, LDN, RD, CISSN, FISSN, is a leading nutritional biochemist and expert on health optimization. He has formulated over 500 supplements, foods, beverages, and cosmeceuticals, has patented 10 novel ingredients, and is now known as the Ingredientologist—the scientist of ingredients. Formerly a chief clinical dietitian with over a decade of clinical experience, he has counseled thousands of people on natural health solutions such as keto, paleo, fasting, and supplements. He has also personally overcome various health issues including Epstein-Barr virus, chronic fatigue syndrome, fibromyalgia, depression, insomnia, obesity, and a pituitary tumor. As a world-renowned thought leader on mitochondrial health, he has been paid to speak on five different continents. His insights have been prominently featured in documentaries, nationally syndicated radio programs, and regularly on morning television. Shawn's expertise can help any health-conscious individual to better manage stress and experience higher performance and more energy through utilizing his practical research-backed solutions. During this discussion, you'll discover: -What Shawn had for breakfast the day of the interview...7:11 He was 40 hours into a 72-hour fast 36 to 48 hours into the fast is when he starts to feel amazing Pique fasting tea Redmond Real Sea Salt Redmond Re-Lyte Electrolyte Drink Mix Hypernatremia, and why slight dehydration isn't a bad thing for performance...9:40 Hypernatremia: not enough sodium in the blood Athletes are not only more hypernatremic than dehydrated, but usually both Electrolyte formulas are fine, but more salt is lost while sweating Keto dieters tend to be hypernatremic Hunger and headaches may be a sign of hypernatremia rather than a lack of water Redmond Real Salt (contains trace minerals, family-oriented company) Real salt tested low in contamination (no anti-humectant added to dry out the salt) Celtic Sea Salt (recommended by Robert Slovak) Ben's morning hydration regimen: Adds Quinton Hypertonic Minerals to well water from his property Vitamin C 2:1 ratio to baking soda Water and Wellness hydrogen tablets BGF podcasts on deuterium depleted water Deuterium Demystified: Everything You Need To Know About Deuterium Depleted Water (DDW), How To Lower Deuterium & Much More, With Dr. Ann Cooper And Dr. Que Collins. Water & Water Filtration: Everything You Need To Know About Water Filters, Alkaline Water, Structured Water, Hydrogen-Rich Water, Deuterium-Depleted Water & Much More, With Robert Slovak. Why The War On Cancer Has Failed & What You Can Do About It: Mistletoe, NAD, Deuterium Depleted Water, Melatonin, Gerson Therapy & Beyond, With Dr. Thomas Cowan Vape Pens, Hair Growth Serums, Fixing The Pineal Gland & C60 (The Next Great Longevity Molecule), With Ian Mitchell. H2Bev hydrogen water in a can (use code BEN to save 10%) Avoid glyphosate like the plague (Roundup) -Optimizing glutathione levels for optimal mitochondria...21:35 Mitochondrial glutathione is the main line of defense against cell death; prevents impairment of the electron transport chain N-Acetylcysteine (NAC) is one of the best ways to boost glutathione AlmsBio Mitotherapy, with PQQ and COQ10 (use code BENGREENFIELD10 to save 10%) Bioadvantex's PharmaNAC Thorne NAC (what Shawn uses) -The criteria by which Shawn evaluates a supplement brand...25:30 Contract manufacturing is in some ways better than in-house Thorne, Standard Process, Pure Encapsulations invest heavily in quality control BioTrust spent 2 years working on a formula with Shawn The Nitty-Gritty Underground World of Supplement Ingredients, Sports Nutrition Frankenfuels, Illegally Laced Compounds & More, With Shawn Wells. You get what's on the label, and you don't get what's not on the label A little bit more pricey, but you're paying for that quality Beware of vegetable oils or "proprietary blends" Companies use the leaf or stem in their product when they should be using the root Gingko has to be the leaf; ginseng has to be the root -How Shawn discovered two substances and made them into supplement form...35:45 Theacrine and Dynamine™ Worked with Dr. Hector Lopez and Dr. Tim Ziegenfuss Methylliberine (Dynamine™) In the methylxanthine family (of which caffeine is a part) Enhanced energy and focus Pain reduction Stimulated NAD production No habituation effect as you find in caffeine Less adaptation effect Biggest difference is the half-life Infopathy generator (use code BENG10 for 10% off) (Ben's podcast with Anton Federenko will be published on February 27) Hapbee wearable Theacrine and Dynamine™ are full synthetic (GMP and informed-choice tested for sports - tested athletes can use it); natural extraction is cost-prohibitive, but it does occur naturally in tea leaves and cacao Shawn's energy stack: Creatine Dynamine™ Alpha GPC -The exercise augmenter that has been called "exercise in a bottle"...44:15 Advanced Smart Drugs & Nootropics You’ve Never Heard Of, Rare Japanese Seaweed For Sleep Enhancement, The Most Powerful Form Of Vitamin B1 That Exists & Much More! With Lucas Aoun. Ergogenic Health β-aminoisobutyric Acid - L-Baiba is an exercise mimetic (exercise augmenter) Intense exercise breaks down BCAA muscle pool to use those amino acids for fuel for the workout L-Valine ends up converting into L-Baiba Mitoburn (L-Baiba) Positive things associated with exercise are enhanced when L-Baiba levels are increased in plasma Brown adipose tissue is brown because of the amount of iron; it's more mitochondrially dense (only 2% or so in your body); burns fat like nothing else Babies can't shiver until about 6-9 months to create heat thermogenesis; we have brown adipose tissue for that reason It is around your collarbone because that's your core; it's important to keep heat near your core More brown adipose tissue may be a factor in one's metabolism -Grains of paradise...49:55 Grains of paradise is a type of pepper, gingery taste; similar to capsaicin and ginger Enhances metabolism without a stimulant effect 40mg increased thermogenesis and caloric expenditure of around 100 calories a day -Ben's super easy goals for his upcoming 40th birthday...52:15 Humans are the easiest to kill in all of history Goldilocks zone - just the right amount of hormetic stressors Polyphenols are xenohormetics to plants "Strong people are harder to kill than weak people—and more useful in general." Why Strong People Are Harder To Kill (And How To Get Strong), With Keith Norris. Ben's 40th birthday activity: complete in a 40 hour fasted state: 2-3 rounds of Wim Hof breathing leading up to a 4-minute static breath-hold 1 40 kg kettlebell Turkish get-up per side 4-minute dead hang from a bar  400-meter farmer's walk with a kettlebell in each hand (40kg) 4-minute ice bath at 32°F (use code BENFORGE to save $150 off any Forge) -A different form of berberine that is used to control blood glucose levels...56:30 A Rocket Scientist Homeschooler’s Insider Blood Glucose Monitoring Secrets, The Best Way To Use A Continuous Glucose Monitor (CGM), Blood Sugar Biohacking Tips & Much More, with Josh Clemente of Levels Health Dihydroberberine Consuming berberine at the gut level converts it to dihydroberberine; at the plasma level it is converted back to berberine Berberine is a glucose disposal agent Dihydroberberine is Shawn's number 1 recommended anti-aging ingredient 5x more bioavailable than berberine, and lasts around twice as long Doesn't give you GI distress that you get berberine Mitochondrial hormetic -Shawn's new formula for BHB and thoughts on exogenous ketones...1:03:30 HVMN ketone ester Ketone Aid Patent on active isomer RBHB (aka DBHB) Exogenous ketones can carry excess minerals; causes some GI distress All in powder form, very salty in taste -Preferred medium-chain triglycerides (MCTs) to go with ketones...1:07:00 Caprylic acid (C8) is best for increasing ketones Lauric acid is great as a virucidal and anti-bacterial; monolaurin for the immune system Dom D'Agostino has a patent pending (ketone + C8) Which Ketone Supplement Works Best: Ketone Salts vs. Ketone Esters With Dr. Dominic D’Agostino. -The best way to raise NAD levels...1:09:20 NMN (use code GREENFIELD10 to save 10%) is better than NR Ben Greenfield Interviews Dr. David Sinclair About Lifespan: Why We Age―and Why We Don’t Have To. Intranasal supplements (use code BEN to save 5%) are often administered incorrectly Getting a quality NMN and the correct amount Fisetin, NMN, apigenin the ultimate stack Add in COQ10 and PQQ for the ultimate mitochondrial stack Article by John Lieurance: Mito Fast: A Brand New Advanced Anti-Aging Protocol To Nurture Your Mitochondria, Boost Autophagy, & Rejuvenate Your Stem Cells.  Iontophoresis NAD patches -And much more! Resources from this episode: - Shawn Wells: The ENERGY Formula: Six Life Changing Ingredients to Unleash Your Limitless Potential The Nitty-Gritty Underground World of Supplement Ingredients, Sports Nutrition Frankenfuels, Illegally Laced Compounds & More. - Podcasts and article: Deuterium Demystified: Everything You Need To Know About Deuterium Depleted Water (DDW), How To Lower Deuterium & Much More, With Dr. Ann Cooper And Dr. Que Collins. Water & Water Filtration: Everything You Need To Know About Water Filters, Alkaline Water, Structured Water, Hydrogen-Rich Water, Deuterium-Depleted Water & Much More, With Robert Slovak. Why The War On Cancer Has Failed & What You Can Do About It: Mistletoe, NAD, Deuterium Depleted Water, Melatonin, Gerson Therapy & Beyond, With Dr. Thomas Cowan Vape Pens, Hair Growth Serums, Fixing The Pineal Gland & C60 (The Next Great Longevity Molecule), With Ian Mitchell. Advanced Smart Drugs & Nootropics You’ve Never Heard Of, Rare Japanese Seaweed For Sleep Enhancement, The Most Powerful Form Of Vitamin B1 That Exists & Much More! With Lucas Aoun. A Rocket Scientist Homeschooler’s Insider Blood Glucose Monitoring Secrets, The Best Way To Use A Continuous Glucose Monitor (CGM), Blood Sugar Biohacking Tips & Much More, with Josh Clemente Which Ketone Supplement Works Best: Ketone Salts vs. Ketone Esters With Dr. Dominic D’Agostino. Ben Greenfield Interviews Dr. David Sinclair About Lifespan: Why We Age―and Why We Don’t Have To. Why Strong People Are Harder To Kill (And How To Get Strong), With Keith Norris.Mito Fast: A Brand New Advanced Anti-Aging Protocol To Nurture Your Mitochondria, Boost Autophagy, & Rejuvenate Your Stem Cells. - Food and supplements: Pique Tea Redmond Real Sea Salt Redmond Re-Lyte Celtic Sea Salt Quinton Hypertonic Vitamin C Baking Soda Water and Wellness Hydrogen Tablets H2Bev (use code BEN to save 10%) NAC AlmsBio Mitotherapy (use code BENGREENFIELD10 to save 10%) Bioadvantex's PharmaNAC Theacrine Dynamine™ Infopathy (use code BENG10 for 10% off) Creatine Alpha GPC L-Valine Mitoburn (L-Baiba) Grains of Paradise Dihydroberberine Berberine HVMN Ketone Aid Caprylic Acid (C8) Monolaurin NMN (use code GREENFIELD10 to save 10%) Nicotinamide Riboside NeuroNAD Intranasal Spray (use code BEN to save 5%) Fisetin Apigenin COQ10 PQQ NAD Patches - Other resources: Hapbee Wearable Kettlebell Morozko Forge (use code BENFORGE to save $150) Wim Hof Breathing Methylxanthine Turkish Get-up Video Dead Hang Video Farmer's Walk with a Kettlebell Video Episode sponsors: -Kion Coffee: Carefully selected and roasted for taste, purity, high antioxidants, and health. BGF listeners save 20% off your first order with code BGF20. -Chili Technologies: ChiliSleep makes both the chiliPAD and OOLER, innovative options that fit over the top of your mattress and use water to control the temperature of your bed and help lower your core body temperature to trigger deep, relaxing sleep. -Paleovalley Beef Sticks: 100% grass-fed AND grass-finished. Keto friendly and higher levels of Omega 3 Fatty Acids. Receive a 15% discount on your order when you use my link. -Butcher Box: Delivers healthy 100% grass-fed and finished beef, free-range organic chicken, and heritage breed pork directly to your door on a monthly basis. All their products are humanely raised and NEVER given antibiotics or hormones.  -Spiritual Disciplines Journal: The new Spiritual Disciplines Journal by Ben Greenfield is coming soon! Sign up to download a free preview and get notified once it's ready. Do you have questions, thoughts, or feedback for Shawn or me? Leave your comments below and one of us will reply!