Podcasts about compounds

BUFFALO, NY – June 8, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on June 3, 2026, titled “The anticancer effects of PCAIs in pancreatic cancer cells involve MAPK and PI3K/AKT pathways hyperactivation.” The study was led by first author Kweku Ofosu-Asante and corresponding author Nazarius S. Lamango from the Florida A&M University College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health in Tallahassee, Florida. Pancreatic ductal adenocarcinoma is among the deadliest forms of cancer, due in large part to the high frequency of KRAS mutations that drive tumor growth and resistance to treatment. Although targeted therapies have recently been developed for specific KRAS mutations, many patients continue to have limited treatment options, highlighting the need for broader strategies capable of targeting multiple KRAS-driven cancers. In this study, researchers investigated a class of experimental compounds known as polyisoprenylated cysteinyl amide inhibitors (PCAIs), which were originally designed to disrupt abnormal KRAS signaling. Using pancreatic cancer cell lines carrying KRAS mutations, the team explored how these compounds affect cancer cell survival, migration, invasion, and the molecular pathways that regulate tumor growth. Full press release - https://www.oncotarget.com/news/pr/experimental-compounds-trigger-cancer-cell-death-in-kras-driven-pancreatic-cancer/ DOI - https://doi.org/10.18632/oncotarget.28879 Correspondence to - Nazarius S. Lamango - nazarius.lamango@famu.edu Abstract video - https://www.youtube.com/watch?v=asbhjME7rFQ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28879 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PCAIs, PDAC, MAPK, PI3K/AKT, KRAS To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Last year, a mysterious source reached out to WIRED's senior writer Andy Greenberg — someone who claimed to be an engineer trapped in a scam compound in Laos. According to the whistleblower, the compound's illicit tactics specialized in pig butchering scams: sophisticated online tactics to build a romantic, trustworthy relationship with a victim before scamming them. Brian sat down with Andy earlier this year to break down how the whistleblower revealed — and fled — the inner operations of the compound. Originally published on February 5th. Articles mentioned in this episode:He Leaked the Secrets of a Southeast Asian Scam Compound. Then He Had to Get Out Alive | WIREDJoin WIRED's best and brightest on Uncanny Valley as they dissect the collision of tech, politics, finance, and business, from the newest ventures to the effects of inaccurate information from artificial intelligence (AI) chatbots on social protests. Learn about your ad choices: dovetail.prx.org/ad-choices

10 million deaths a year.  That is how many people are predicted to die from antibiotic-resistant infections if we do not find new treatments. In today's episode, Professor Martha Clokie and Professor Tim Spector explore the secret gut viruses, known as phages, being studied to fight deadly infection, target cancer cells, and to protect your gut microbiome.  Martha is a world-leading expert on the mysterious phage and, for the last 20 years, has pioneered research to revolutionise the treatment of infections without antibiotics. She explains why antibiotic resistance is a growing global threat, why everyday infections are becoming harder to treat, and how some bacteria are now resistant to every antibiotic available. We explore how the viruses in our gut may help solve this problem, and how scientists may one day use them to deliver highly targeted cancer treatment. By the end of the episode, you'll have some ideas to help support a healthier gut ecosystem and understand how to increase the number of friendly gut viruses that live inside you. The science is still early, but the message is clear: the small choices we make every day are shaping our long-term resilience to disease. If viruses can help protect us from infection rather than cause it, how much of human health are we only just beginning to understand?

A screencast from Chapter 19 in CH 223 entitled “Coordination Compounds”

Creatine and Microbiomes A new 2026 Cell Metabolism study explores a compelling and increasingly central idea in modern biology: the gut/brain/immune/metabolism axis is not just associative, it is mechanistic. Specifically, Dr. Lu and colleagues investigate how the gut microbiota can directly influence depressive behavior by reshaping systemic and neural metabolism. This is another in a long running list of papers describing the amazing work that bacterial commensal microbes do for us. In this case, our minds and moods. "Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic profiling to reveal elevated fecal creatine alongside reduced plasma and cerebrospinal fluid creatine in both patients with depression and mouse depression models. Exogenous creatine produced antidepressant-like effects mediated by gut microbiota. Bifidobacterium pseudolongum was identified as a significantly reduced gut bacterial species in depression, correlating with impaired creatine absorption. Subsequent supplementation with Bifidobacterium enhanced the antidepressant effects of creatine. Mechanistically, B. pseudolongum-derived acetate promoted the creatine transporter (Slc6a8) expression in intestinal epithelial cells via histone acetylation. The Slc6a8 mediated the antidepressant-like effects of creatine. Neuronal creatine deficiency influenced energetic metabolism and neurophysiological function. In patients with depression taking antidepressants, co-administration of creatine and Bifidobacterium increased plasma creatine levels and reduced depression scores. These findings identify the Bifidobacterium-creatine combination as a promising antidepressant strategy and highlight the critical role of gut-brain energy metabolism in depression." "The brain, as an energy-intensive organ, relies on precise metabolic regulation to maintain synaptic plasticity, neurotransmitter synthesis, and stress response systems. Accumulating evidence implicates energy metabolism dysregulation as a hallmark of depression. Neuroimaging studies using positron emission tomography (PET) have identified marked glucose hypometabolism in the medial prefrontal cortex (mPFC) of patients with depression. Cerebral mitochondrial dysfunction and ATP imbalance have been mechanistically linked to depression progression. Notably, emerging studies emphasize the bidirectional interplay between peripheral metabolic signals and central energy regulation, which is fundamental to neural metabolism. Clinical observations such as fatigue, appetite dysregulation, and unexplained weight fluctuations in patients with depression further suggest systemic metabolic disturbances spanning peripheral organs and the CNS.." (Lu et. al. 2026) This is next-level medicine. Mental health can no longer be framed as a disorder of genetics, experience, or circumstance alone. This work opens a clearer window, showing how the microbiome participates as an active partner, shaping brain function through the metabolites it helps produce and deliver. Compounds like creatine are no longer just peripheral players. They become signals, fuel, structure, and information, bridging gut and brain, metabolism and behavior.... and more Enjoy, Dr. M

Did you catch our excellent recent article? Titled Beyond Aroma: Hop enzymatic activity, diastatic power, and fermentation control, Francesco Lo Bue and Philip Wietstock, Professor and Chair of Brewing and Beverage Technology at TU Berlin, brought together recent research on hop diastatic power with observations on enzyme distribution within the hop cone, to provide a more complete understanding of how hops influence fermentation beyond flavour. As they explain, hops have long been evaluated through aroma and bitterness. That framework no longer reflects how hops behave in modern brewing. So with that in mind, we’re revisiting Francesco’s brilliant talk from our 2025 Brewers Congress. Francesco is an agronomist with a degree in food technology, specialised in hops aromatic compounds. And in London he outlined how hop compounds peak at different times and explained how brewers can bring them all into the beers they brew through a number of actionable tips. We hope you enjoy…

In dieser Folge dreht sich alles um das Thema Materialfreigabe. Was steckt hinter der Freigabe eines OEMs? Gibt es Unterschiede zwischen Material- und Bauteilfreigabe? Wie lange dauert ein Projekt zur Freigabe eines Compounds? Das alles und noch mehr beantwortet Andre Schrader von der MOCOM Compounds GmbH & Co. KG. Mehr zu MOCOM: www.mocom.eu Mehr zum SKZ Prüflabor: https://www.skz.de/pruefung Weiterbildungen im Bereich Material und Compoundieren: https://www.skz.de/bildung/kurse

I didn't leave X because it failed.I left because I realized something most people still don't understand:You don't own your audience.For years, I played the game—posting, engaging, building visibility.It looked like progress. It felt like momentum.But attention isn't ownership.It's rented.In this episode, I break down why I stopped chasing distribution—and started building something that compounds.This isn't about platforms.It's about control.Ownership.And building something that actually lasts.If you're a builder, not a promoter—this is for you.—Crypto Hipster PodcastMaking sense of the digital economy—through the people building it.Where builders talk freedom, not price.

Struggling to choose between taping, topping, and all-purpose drywall compounds? Discover why the industry is overdue for a material rethink and how switching to a single, high-performance system can cut labor, boost health, and improve your bottom line. Learn more at https://phoenixfinish.com/ Phoenix Advanced Materials City: Southlake Address: 2600 East Southlake Boulevard Website: https://phoenixfinish.com/

Send us Fan MailIn this episode of the B2B Go-To-Market Leaders Podcast, Vijay Damojipurapu sits down with Holly Roland, former executive at SAP and Oracle and founder of Rebel GTM, to break down what go-to-market really means in today's AI-driven world.Holly introduces a simple but powerful framework: go-to-market is an infinity loop of discovery and value, where buyers move from awareness to purchase, and then into expansion, cross-sell, and advocacy. Yet most B2B companies still over-index on acquisition while underinvesting in the value loop.Drawing from decades of experience across enterprise tech and startups, Holly shares how she evolved from product management into go-to-market leadership, and why she ultimately built Rebel GTM to help companies align product, marketing, sales, and customer success into one unified system.They dive into:Why go-to-market should be viewed as a discovery loop + value loop, not just a funnel.The common mistake B2B companies make by prioritizing new logos over expansion.How marketing alone can't fix growth if upstream and downstream functions are misaligned.Career lessons on moving from IC roles to leadership through collaboration and influence.Why storytelling and positioning are as important as the product itself.The rise of Generative Engine Optimization (GEO) and how it's reshaping digital presence.A real-world GEO case study that improved readiness from ~30% to nearly 80% in weeks.Why LLM-driven traffic produces higher-intent, higher-conversion buyers than traditional SEO.The importance of reframing your product to match how customers think (not how you describe it).Practical ways to approach AI in GTM; starting with workflows, not tools.Holly's core message is clear:Great go-to-market isn't about isolated tactics. It's about aligning the entire company around how customers discover, buy, and realize value.This episode is a deep dive into modern GTM strategy, combining foundational principles with emerging trends like AI and GEO that are redefining how companies reach and convert buyers.Connect with Vijay Damojipurapu on LinkedInConnect with Holly Roland on LinkedInBrought to you by: stratyve.com

HAPPY 420! Cult Cup just 12 days away. Grab your tickets at growcast.com/events (00:00) Intro and newly discovered aromatics (03:26) Consumption method flavor nuance (10:19) Heat as a flavor catalyst (15:58) Riley's grow and veggie garden This is a part two with Riley Kirk, you can catch up on the last episode or just pick up right here! On this installment, Riley talks about the nuance of flavor that comes from compounds (some of which are just being discovered) not only being present and produced by our flowers- but also by interacting and transmuting when introduced to things like heat and pressure. Riley also shares some insights into her own grow, as a researcher who also takes the extra step to grow the plant herself. BOGO on GrowCast Seed Co: www.growcast.com/seeds 42% off www.rootedleaf.com with code GROWCAST this week only Join GrowCast Membership TODAY! The best community in cultivation. Personal 24/7 garden support, Members Only content and discounts, and the Grand Pheno Hunt! www.growcast.com/membership  Code GROWCAST15 now works with grow KITS from AC Infinity! www.acinfinity.com use promo code GROWCAST15 for 15% off the BEST grow fans in the game, plus tents, pots, scissors, LED lights, and now REFILLABLE FILTERS!

Estropipate, paclitaxel and levocarnitine altered behaviors tied to SCN2A and DYRK1A variants specifically, a new open-source platform revealed.

Contractors are driving a shift toward mineral-based, zero-VOC drywall compounds that deliver superior workability, durability, and healthier indoor environments. Discover what's fueling this transformation and how performance-driven formulations are redefining professional finishing standards. To learn more, visit https://phoenixfinish.com/ Phoenix Advanced Materials City: Southlake Address: 2600 East Southlake Boulevard Website: https://phoenixfinish.com/

You've heard how the compounds work. This week we go inside one—through the eyes of Small Q, an Ugandan musician who was trafficked in and got out—also: Erin West of Operation Shamrock on the bigger picture.  Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of Fraudology, Karisse Hendrick welcomes back Erin West, prosecutor and founder of Operation Shamrock, for an urgent update on the global "scamdemic" of pig butchering. Erin shares firsthand accounts from her recent investigative trip to Cambodia, providing a chilling look at the industrialized nature of transnational organized crime and the massive scale of the scam compounds operating in the region.The conversation explores the recent waves of accountability, including the historic U.S. indictment of Cambodian/Chinese kingpin Chen Ji and the subsequent $15 billion forfeiture—a move that has sent ripples of fear through the industry. Erin details the "Super Bowl effect" she witnessed in Sihanoukville, where compounds appeared shuttered for show while operations continued behind locked metal doors and shuttered windows.We also explore the "hot topics" dominating the fraud landscape today:The GDP of Fraud: How the scam industry now accounts for an estimated 40% to 60% of Cambodia's GDP, making total eradication a complex economic and humanitarian challenge.Industrialized Deception: Why these compounds resemble corporate training rooms—complete with cubbies for personal phones and strict "fine" schedules for victims—proving this is a highly systemized global industry.The Liability Lever: A look at how platforms like Meta successfully block scam ads in Australia where they face financial liability, while failing to do so in regions where "teeth" in the law are missing.Building the Coalition: How Erin's crypto-coalition has grown to 2,400 members, bridging the gap between local law enforcement and federal agencies to ensure victims are no longer turned away.Additionally, Erin dives into the heartbreaking reality of the "generation's worth of wealth" being stolen from Western countries to fund "mint-colored Rolls Royces" and garish displays of luxury in Phnom Penh. We conclude with a call to action for fraud professionals to "Train the Trainer," using Operation Shamrock's resources to educate their own communities and break the echo chamber.

Most rental companies compete on equipment. The ones pulling ahead are competing on something harder to copy. In this episode, Kyle sits down with Elliott Vigil, one of the most respected sales coaches in the construction equipment industry, to break down why trust is the only competitive advantage that truly compounds, how to apply the Pareto principle to your customer base, and why Elliott believes AI is still under hyped in rental.

PART ONE OF TWO Cult Cup 2026, Saturday May 2nd, Loves Park IL! Don't miss the biggest event of the year: www.growcast.com/events  (00:00) Introduction & staying connected with patients (06:05) Skatole resembles DMT (09:31) Compounds that make experiences go "up or down" (14:13) Follow your nose (18:48) Riley's favorite medicinal compound Fan favorite Dr. Riley Kirk returns to the program to pick up right where we left off. Today she is here to discuss how aromatic compound affect our canna experience, and also how they affect our health. Riley points out some of her favorite compounds and extrapolates on how they function in the human body, and shares some interesting facts around more psychedelic chemovars... Join GrowCast Membership TODAY! The best community in cultivation. Personal 24/7 garden support, Members Only content and discounts, and the Grand Pheno Hunt! www.growcast.com/membership  Code GROWCAST15 now works with grow KITS from AC Infinity! www.acinfinity.com use promo code GROWCAST15 for 15% off the BEST grow fans in the game, plus tents, pots, scissors, LED lights, and now REFILLABLE FILTERS!

The biggest operational advantage in multifamily usually starts with changes so small most teams ignore them.Incremental improvement rarely feels dramatic, which is exactly why so many leaders undervalue it. In multifamily operations, people tend to notice sweeping changes, new initiatives, and bold announcements. What often gets missed is that small, repeated improvements usually create the most durable advantage over time.A slightly better turn process matters. A clearer communication habit matters. A marginally faster response time matters. None of those changes feel revolutionary on their own, but when they are repeated daily, they begin to compound. Over time, that consistency outperforms the sporadic big move that never fully takes hold.That is where discipline enters the picture. Discipline is hard work because it asks people to do the simple things well, over and over again, without needing applause every time. But that discipline creates freedom. It reduces chaos. It builds trust in the process. It gives teams a rhythm they can actually sustain.This is one reason continuous improvement works so well in apartment operations. Teams can absorb incremental change without feeling exhausted by it. Small improvements build confidence instead of resistance. They help progress feel achievable. When people believe progress is possible, they participate more willingly and execute more consistently.Compounding works quietly. It rewards patience, discipline, and consistency long before it gets recognized from the outside. The multifamily operators who commit to steady improvement often outperform the ones chasing breakthrough ideas that sound exciting but never fully land in the day-to-day business.That is the real takeaway. Do not underestimate the power of a better process, a better habit, or a better standard repeated over time. In multifamily, the operators who win are often the ones who get a little better every day and stay committed long enough to let that improvement stack up.Subscribe now. Every episode is built for multifamily operators who want practical ideas that improve execution, strengthen culture, and help teams get better one day at a time.MultifamilyCollective Blog: https://www.multifamilycollective.comThe Daily Collective Book: https://amzn.to/3YI6BDaHosted by: https://www.multifamilymedianetwork.com

You're eating “healthy.” You're reading ingredients. And yet… the migraines keep coming.What if the trigger isn't obvious but hiding in plain sight under different names on the label?In this episode of Migraine Heroes Podcast, host Diane Ducarme uncovers five common but often disguised food compounds that can quietly activate a sensitive migraine brain. These ingredients aren't always listed in ways you'd expect and for some people, they can significantly lower the migraine threshold.Blending neuroscience with practical food awareness, this episode helps you move from confusion to clarity without fear or food obsession.You'll discover:

The video version of this episode--------------------------------------------My short, clear overview of everything you need to know about the Group 2 elements, and some of their compounds.--------------------------------------------Check out the Chemistry Made Simple academyFind out more about the Chemistry Made Simple academyContact me:Instagram @chemistrymadesimpleEmail Matthew@ChemistryMadeSimple.netRecord a voice note for me: chemistrymadesimple.net/voicenoteJoin the discussion at the Chemistry Made Simple podcast community.

Chocolate is often blamed for migraines. But what if it's not the chocolate itself, it's which compound inside it your brain reacts to?In this episode of Migraine Heroes Podcast, host Diane Ducarme breaks down the five active compounds in chocolate that directly influence your nervous system, blood flow, and migraine threshold. Because for some brains, chocolate enhances focus and mood. For others, it quietly lowers the threshold for an attack.You'll discover:

Markwayne Mullin embarrassed himself in his Senate confirmation hearing yesterday. Steve Schmidt breaks down the exponential idiocy of Trump's cabinet and warns of the growing threat to the U.S. Constitution. Today's Merch: Constitution Is Kinghttps://thewarningwithsteveschmidt.com/products/constitution-is-king-tee Subscribe for more and follow me here:Substack: https://steveschmidt.substack.com/subscribeStore: https://thewarningwithsteveschmidt.com/Bluesky: https://bsky.app/profile/thewarningses.bsky.socialFacebook: https://www.facebook.com/SteveSchmidtSES/TikTok: https://www.tiktok.com/@thewarningsesInstagram: https://www.instagram.com/thewarningses/X: https://x.com/SteveSchmidtSESSee omnystudio.com/listener for privacy information.

We celebrate our 250th episode of the Elite Business Advice Podcast in the best way we know how: talking about the role consistency plays in our business and our personal lives. We thought it would be a fitting episode to have this discussion as today marks 250 straight weeks we've put out a new episode. We also share this milestone with some of our listeners and clients from hearing their most impactful takeaway during this journey!If you're looking to be more intentional with your business this year how some of our clients mentioned in this episode, start the process with us by scheduling a free business analysis meeting at www.elitebusinessadvisors.com

Living a Nutritious Life PodcastIn this episode of Living a Nutritious Life podcast, we are thrilled to welcome Barbara Ruhs, MS, RDN, a Registered Dietitian Nutritionist and expert on the health attributes of extra virgin olive oil.About Our Guest:Barbara Ruhs is a nationally recognized nutrition leader and the USA Lead Dietitian for Cobram Estate. As a marketing and communications nutrition expert, she has shaped nutrition strategies for well-known food brands and raised the health profile of underrated fruit from pears, avocados to olives.What You'll Learn in This Episode:- The science behind why extra virgin olive oil is so beneficial — and what sets it apart from regular olive oil.- How to spot truly high-quality extra virgin olive oil in the grocery store.- The latest research on extra virgin olive oil's unique phenolic compounds (like oleocanthal) and their impact on inflammation and overall health.- Best practices for storing, cooking, and maximizing the nutritional punch of your extra virgin olive oil.Episode Highlights:- Barbara's fascinating career path, from collegiate athlete to avocado industry leader to extra virgin olive oil expert.- What makes extra virgin olive oil superior for your heart and anti-inflammatory health.- Decoding extra virgin olive oil labels: how to know you're actually getting extra virgin quality and the shocking results from a UC Davis study.- Should you take “shots” of extra virgin olive oil plus how to pair extra virgin olive oil with other healthy foods for maximum absorption.About Living a Nutritious Life Podcast:Welcome to the Living a Nutritious Life podcast with Keri Glassman, MS, RDN, CDN, where we break down the latest nutrition science into smart, actionable tips to help you live your most nutritious life.On the Living a Nutritious Life podcast, Keri and her world-renowned guests cut through the noise, sharing unparalleled, forward-thinking tips, tricks, and the latest in health, wellness, and nutrition science.Based on Keri's whole-person approach to healthy living, each impactful episode extends far beyond the simplistic “get more sleep” and “eat your greens” advice. She connects the dots like no one else – like how morning yoga can make it easier to choose a healthy lunch, leading to better sleep at night.Listen as Keri and her expert guests explore the physiological and behavioral connections that explain, for example, why the common wisdom around dieting and exercising alone doesn't work, so you can finally make the meaningful changes you've been looking for.Thank you for listening in to this episode of Living a Nutritious Life. We hope you enjoyed the conversation as much as we did! If you found value in this episode, please RATE, REVIEW and SHARE.Join our amazing global community of like-minded students and alumni. Get in on the action—enroll in our Become a Nutrition Coach program at nutritiouslife.com/bnc.Connect with Barbara:Website: https://cobramestate.com/healthprofessionals/If Food is Medicine, Extra Virgin Olive Oil is the First Prescription: https://www.aboutoliveoil.org/food-is-medicine-olive-oilIG: www.instagram.com/cobramestateusa/FB: www.facebook.com/cobramestateusa/Not All Extra Virgin Olive Oil is Equal: Fresher is Better - Cobram-Estate-What-is-Extra-Virgin-Olive-Oil.pdfDid You Know You Can Cook with Extra Virgin Olive Oil? - Cobram-Estate-Cooking-with-EVOO-US VERSION-2025074JKD5-highresConnect with Keri on social:Instagram: https://www.instagram.com/nutritiouslifeofficial/Instagram: https://www.instagram.com/keriglassman/TikTok: https://www.tiktok.com/@keriglassmanFacebook: https://www.facebook.com/KeriGlassmanNutritiousLifeTwitter: https://twitter.com/NutritiousLife_LinkedIn: https://www.linkedin.com/company/nutritiouslifePinterest: https://www.pinterest.com/nutritious_life/Website: https://nutritiouslife.com/Become a Nutrition Coach: https://nutritiouslife.com/bnc/Copyright © 2023-2025 Nutritious Life.#LivingaNutritiousLife #NutritiousLife Hosted on Acast. See acast.com/privacy for more information.

Hey all you Vipers! Mr and Mrs Weedman are back with another round of great cannabis news, hot topics, headlines, research and reports. Before they get going, they get normal -  seshing on some Juicy Fruit flower from their friends @Midwest_Terps.  Mr Weedman shares a recent federally funded study finding most consumers are replacing medications with CBD and a new research report finding CBD useful when treating liver diseases. Mrs Weedman talks about the potential for cannabis as a legitimate medicine for menopause, she shares a research report on the munchies and how cannabis affects appetite, and she talks about the women shaping today's regulated market.   Support The Show: https://www.buzzsprout.com/283607/supportTWITTER: @weedman420podYouTube: Weedman420 ChroniclesEMAIL:  weedman420chronicles@gmail.comSHOP: www.eightdecades.comIG: @eightdecadesEMAIL: eightdecadesinfo@gmail.com#CannabisTruth #StomptheStigma #HomeGrow #FreethePlant #Stoners #rosin  #Potheads #Vipers #CannabisCultureEducation #CannabisResearch #Weed #Marijuana #LegalizeIt #CannabisNews #CBD #Terpenes #PodcastCannabis #eightdecades #CannabisLifestyle #HealthyLifestyle #NaturalMedicine #CannabisIndustry #PlantMedicine #News #WeedResearch #MedicalMarijuana #Infused #420Podcast #420Education #Health #WeedWellness #WorldNews #Gardening #budtender #420Culture #hemp #dabs #hash #joints #edibles #weed #gummies #tincture #vapes #pauliesayssmokesmartArticle Links:*  https://www.marijuanamoment.net/millions-of-americans-use-cbd-as-a* https://www.greenstate.com/health/cannabis-menopause-symptoms/?utm_source=flipboard&utm_content=topic/cannabidiol* https://www.foxnews.com/health/cannabis-compounds-could-reverse-disease-affecting-one-third-adults?utm_source=flipboard&utm_content=user%2FFoxNews* https://www.marijuanamoment.net/scientists-reveal-what-types-of-food-the-marijuana-munchies-make-you-crave-the-most/?utm_source=flipboard&utm_content=ChefJeff314%2Fmagazine%2FCannabis+Currently* https://www.greenstate.com/business/cannabis-leaders-speak-to-the-next-generation-of-women/?utm_source=flipboard&utm_content=GreenState/magazine/GreenState+News+%26+LifeCOPYRIGHT 2021 WeedMan420Chronicles©Suggestions? Questions? Chat with us here.Support the show

In this episode of Scam Rangers, Ayelet Biger-Levin speaks with Nils Mueller, Director of the North America Chapter of the Global Anti-Scam Alliance and former USAID Foreign Service Officer.Nils shares his unique path into the world of scam prevention after spending more than two decades working in international development and governance. During his time in Southeast Asia, he witnessed the rapid rise of industrial-scale scam operations run from organized crime compounds that target victims around the world.Together, Ayelet and Nils discuss how these scam compounds emerged, the human trafficking behind many of these operations, and why online scams have become a national security issue for governments. They also explore how global cooperation between governments, civil society, and the private sector can help disrupt these networks and protect consumers.Topics Covered How scam compounds in Southeast Asia evolved from casino infrastructure into large-scale global fraud operations The human trafficking behind many scam operations and how workers are recruited into these compounds Why scams have become a national security and economic threat, costing billions each year The role of international collaboration, sanctions, and law enforcement in disrupting organized scam networks How the Global Anti-Scam Alliance is bringing together governments, companies, and advocates to coordinate the fight against scamsAbout the GuestNils Mueller is the Director of the North America Chapter of the Global Anti-Scam Alliance and a former Foreign Service Officer with USAID. Over a 20-year career, he worked across Africa and Southeast Asia on governance, anti-corruption, and development initiatives.During his posting in Thailand, Nils became deeply involved in understanding and addressing the rise of scam compounds and the human trafficking networks connected to them.https://www.linkedin.com/in/nils-m-mueller/About the HostAyelet Biger-Levin is the Founder and CEO of RangersAI and the host of Scam Rangers, a podcast exploring the human side of scams and the people working to protect consumers from financial and emotional harm.Through her work at RangersAI and her leadership within the Global Anti-Scam Alliance, Ayelet partners with financial institutions, policymakers, and advocates to elevate scam prevention beyond controls and technology toward trust-based, customer-centric protection.Be sure to follow her on LinkedIn and reach out to learn about her additional activities in this space: https://www.linkedin.com/in/ayelet-biger-levin/RangersAI: https://www.rangersai.com/

After more than three decades in international banking, she has learned that real leadership isn't defined by team size, but by the ability to build trust, listen deeply, and move people toward shared outcomes. Now Country Manager of ING Taipei, Sophia brings a long-term perspective shaped by consistency, intellectual honesty, and care.In this conversation, Sophia reflects on how Taiwan's economic evolution, sustainability in finance, and personal energy management intersect in her leadership approach. From navigating high-stakes negotiations with empathy to viewing capital as a tool for long-term impact, she shares why credibility is built slowly. At its core, this episode is a reminder that leadership isn't about knowing everything but about connecting, listening, and building that trust that moves people to a shared goal.【Her Story】Why leadership is about influence, even in a one-person functionTransitioning from individual contributor to impact-driven leaderHow Taiwan moved up the global value chain — and what that means for finance todayThe role of empathy, listening, and energy management in long-term leadership加入會員，支持節目： https://careher.firstory.io/join留言告訴我你對這一集的想法： Powered by Firstory Hosting

Support the show:https://www.paypal.me/Truelifepodcast?locale.x=en_USOne on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meetingPSYCHEDELIC COMPOUNDSThat No One Has Made But I Think I Would LoveEpisode Six: THALASSINE-7(7-OH-Mitragynine-DMT Conjugate / Sigma-2 Agonist / Cortistatin Analog)“The compound that puts you in the water. The water that is already in you.”✦Episode SummaryThis episode delivers a haunting, second-person narrative of THALASSINE-7, a purely theoretical psychedelic that doesn't flood you with new visions — it turns up the volume on what your body is already screaming, clears the static of self-protection, and holds you in crystal-clear confrontation with the self at depth.Framed through a father and his nine-year-old daughter's real-time fight against a rip current at Three Tables Beach on Oahu's North Shore, the “trip” becomes an unflinching mirror for overconfidence, the weight of trust, ignoring warning signs, and the difference between survival and wisdom.The Compound (Theoretical Pharmacology)•  Backbone: Modified 7-hydroxymitragynine redirected from opioid receptors to sigma-2 agonism (mitochondrial receptors that govern the cellular “continue or quit” decision — literally apoptosis/survival signaling).•  Psychedelic Link: 5-substituted DMT moiety connected via sulfonyl linker, creating allosteric cross-talk that amplifies whatever signal your nervous system is already broadcasting instead of overlaying new hallucinations.•  Rest Component: Cortistatin-14 analog — the same neuropeptide your brain releases in deep slow-wave sleep — brought into full waking consciousness to quiet hippocampal chatter and deliver profound, low-static rest while you remain completely alert.Net Effect: Complete wakefulness + total removal of narrative armor + inescapable bodily truth = an encounter with reality you cannot file away.Status: 100% theoretical / fever-dream medicinal chemistry. No one has synthesized this. The lessons it forces are very real.The Trip Report: Three Tables Beach, Pupukea, North Shore OahuSetting: Overcast grey morning at the beach named for three flat coral reef tables visible at low tide. Multiple posted signs warn of powerful rip currents, hazardous shorebreak, and past deaths. The father enters the water anyway with his trusting daughter on his back.Key Moments (clinical timestamps from the narrative):•  T+0:00 — Reading the signs… and walking in.•  T+0:22 — The current slams. Sigma-2 receptors light up with the body's primal “continue” verdict.•  T+0:25–0:41 — Arm-over-arm fight; daughter silent, gripping, sixty-two pounds feeling like the entire world.•  T+0:58 — Shore reached. Arms shaking in six inches of water. Pride and reckoning land simultaneously.•  T+1:20 — The compound forces both truths at once: I brought her back and I never should have taken her in.•  T+2:00 — Integration on the sand: You are not the exception. Do the work in calm water before the current changes again.Real Location NoteThree Tables Beach (also called Kalua o Māua) is a real spot between Waimea Bay and Sharks Cove. It offers world-class snorkeling in summer but is notorious for sudden, powerful rip currents and rogue waves, especially October–April. Signs explicitly warn “Deaths have occurred,” “Strong rip currents capable of pulling swimmers far out to sea,” and “Enter at your own risk.” Recent incidents include drownings and rescues. There is no permanent lifeguard tower. Always check conditions and heed every sign.Core Themes & Takeaways•  The universal “gap at the sign” — the split-second where information becomes discomfort and we quietly decide “that doesn't apply to me.”•  Holding both pride in what your body refused to quit and accountability for the unnecessary risk.•  The ocean as the cleanest laboratory: it applies the same physics to everyone regardless of how much you love the person beside you or how strong your story says you are.•  Capacities are not equal — this is physics, not morality. The ethical response is ruthless honesty about where you actually are and deliberate work to close the gap.•  Parenting in action: what you model when the signs are clear echoes louder than any lecture.•  “Go do the work. In calm water. Before the current changes again.”Key Quote“You are not the exception. You are a person who, when the situation became the thing it was always warning you it might become, found out what you are actually made of. And what you are made of was enough. This time.”Synthesist's NotesThe specific conjugate (sulfonyl-linked 7-OH-mitragynine-DMT-cortistatin analog) exists only in speculation, but every piece draws from documented science: sigma-2 receptors in mitochondria, cortistatin's role in deep sleep consolidation, and the well-known potency of 7-hydroxymitragynine. What is not speculative is the psychological target — the moment we read a warning and override it with self-flattery. THALASSINE-7 is the compound that refuses to let you file that discomfort under “confidence” and keeps the gap open until it becomes transformation.Next EpisodeCHRONOGEN — a peptide-psychedelic hybrid that does not alter time perception. It alters time preference. The body begins to want the present with such ferocity that past and future lose their gravitational pull. The calendar has been keeping records of every appointment your future self never received. It is not angry. It is just waiting.✦END OF EPISODE SIXTHALASSINE-7 • Status: Theoretical. The signs were always right.Thank you for listening (or reading). If this episode moved you, sit with the gap at your own signs today. The water is already in you. One on One Video call W/George https://tidycal.com/georgepmonty/60-minute-meetingSupport the show:https://www.paypal.me/Truelifepodcast?locale.x=en_US

Behind the texts and crypto pitches flooding your phone is a darker reality: fortified scam compounds where trafficked workers are forced to run industrial-scale fraud operations. In this episode, we break down the latest raids, mass escapes, and high-level extraditions shaking Southeast Asia's scam empire — and why the people sending the messages may be victims too.https://www.pbs.org/newshour/world/why-southeast-asias-online-scam-industry-is-so-hard-to-shut-downhttps://www.theguardian.com/world/2026/jan/21/thousands-of-workers-flee-cambodia-scam-centres-officials-sayhttps://www.reuters.com/world/china/scammers-abandoned-cambodia-compound-exposes-brutality-banality-fraud-2026-02-06/Finding Lucyhttps://www.bbc.com/news/articles/cx2gn239exlohttps://www.youtube.com/watch?v=mNUku0jd4FAPickleball Brawlhttps://people.com/florida-couple-gets-into-heated-pickleball-brawl-with-over-20-country-club-members-11905209 Join our squad! Kristi and Katie share true crime stories and give you actionable things you can do to help, all with a wicked sense of humor.Follow our True Crime Trials Channel: https://www.youtube.com/@TrueCrimeSquadTrialsFollow our True Crime Shorts Channel: https://www.youtube.com/@truecrimesquadshorts-t6iWant to Support our work and get perks like extra content and The Watch Party?www.truecrimesquad.com*Social Media Links*Facebook: www.facebook.com/truecrimesquadFacebook Discussion Group: https://www.facebook.com/groups/215774426330767Website: https://www.truecrimesquad.comTikTok: https://www.tiktok.com/@truecrimesquadBlueSky- https://bsky.app/profile/truecrimesquad.bsky.social True Crime Squad on Spotifyhttps://open.spotify.com/show/5gIPqBHJLftbXdRgs1Bqm1

Support the show:https://www.paypal.me/Truelifepodcast?locale.x=en_USOne on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meetingThe metal detector isn't checking whether the building is dangerous for you…it's checking if you are dangerous for those inside! Episode Five of Psychedelic Compounds That No One Has Made But I Think I Would Love. DIGNIN: a peptide-tryptamine hybrid that temporarily takes the cortisol offline and asks it, at the molecular level, whether the threat is real or just a habit. Spoiler: it's a habit. You built it. You've been maintaining it for years. You're very good at it. This is the compound that shows you the blueprints. One on One Video call W/George https://tidycal.com/georgepmonty/60-minute-meetingSupport the show:https://www.paypal.me/Truelifepodcast?locale.x=en_US

SpaceTime with Stuart Gary Gary - Series 29 Episode 21In this episode of SpaceTime, we explore intriguing revelations about the search for life on Mars, the surprising effects of Saturn's moon Enceladus on its planet, and the monumental volcanic events that reshaped Earth's tectonic landscape.Life on Mars: A New PerspectiveRecent findings suggest that non-biological processes cannot fully explain the organic compounds found in Martian regolith samples collected by NASA's Curiosity rover. Published in the journal Astrobiology, the study indicates that life may have contributed to some of these compounds, challenging previous assumptions. The research involved evaluating potential non-biological sources and concluded that the abundance of organics on Mars could hint at past life, sparking renewed interest in the Red Planet's potential habitability.Enceladus' Electromagnetic InfluenceA fascinating study reveals that Saturn's icy moon Enceladus trails a wake of electromagnetic ripples extending over half a million kilometers, significantly influencing its giant host planet. Data from NASA's Cassini mission demonstrated how Enceladus' geysers contribute to energy and momentum circulation within Saturn's magnetic environment, marking a crucial discovery about the moon's role in the Saturnian system.Earth's Volcanic HistoryNew research highlights how Earth's largest volcanic event, associated with the Ontong Java Plateau, dramatically altered a major tectonic plate. The findings suggest that extensive volcanic activity led to significant physiochemical modifications within the oceanic plate, enhancing our understanding of plate formation processes and the environmental impacts of such massive eruptions.www.spacetimewithstuartgary.com✍️ Episode ReferencesAstrobiology, Geophysical Research Space Physics, Geophysical Research LettersBecome a supporter of this podcast: https://www.spreaker.com/podcast/spacetime-with-stuart-gary--2458531/support.

Cambodia promises to dismantle cyber scam compounds by April, CISA urges companies to adopt the OpenEoX standard, Linux gets post-quantum crypto support, and Palo Alto Networks avoids attributing an APT to China. Show notes Risky Bulletin: Cambodia promises to dismantle scam networks by April

In today's episode of Next Level University, hosts Kevin Palmieri and Alan Lazaros break down why most people underestimate the power of small daily choices and how invisible habits quietly shape success, health, and long-term performance. They reveal how discipline compounds, why coasting after progress is dangerous, and what it really takes to build momentum that lasts.This conversation challenges short-term thinking and exposes the hidden cost of inconsistency, comfort, and delayed action. If you are serious about personal growth, mental resilience, and sustainable achievement, this episode will sharpen your standards and reset how you approach your daily life._______________________Learn more about:Book Alan's Business Breakthrough Session. Your first 30-minute coaching call is FREE. Learn how to prioritize success and let your quality of life become the byproduct. - https://calendly.com/alanlazaros/30-minute-breakthrough-sessionTrack the Work. Earn the Results. To know more about the "Next Level Fitness Accountability Group," reach out.Kevin: https://www.instagram.com/neverquitkid/Alan: https://www.instagram.com/alazaros88/_______________________NLU is not just a podcast; it's a gateway to a wealth of resources designed to help you achieve your goals and dreams. From our Next Level Dreamliner to our Group Coaching, we offer a variety of tools and communities to support your personal development journey.For more information, check out our website and socials using the links below.

What if the line between “medicine” and “forbidden” has nothing to do with safety and everything to do with permission? This episode gives you a clear framework for understanding peptides, research chemicals, and performance enhancement so you can think for yourself instead of outsourcing your biology Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dylan Gemelli for a candid, unfiltered conversation about the underground world of biohacking, research chemicals, and human performance. Dylan is a long-time biohacker, educator, and researcher who came out of the bodybuilding world and spent more than a decade studying peptides, SARMs, nootropics, and gray-area compounds. He brings first-hand experience, deep research literacy, and a rare ability to explain what these compounds actually do, where the risks are, and why most doctors will never talk about them. Together, they unpack what “research chemicals” really means, why peptides technically fall into that category, and how legality often has little to do with biological reality. They explore compounds like MK-677, S4, and other SARMs, how they interact with growth hormone, muscle, strength, and recovery, and why some of these tools can be more powerful than peptides when used with intention and restraint. Dave also shares his own experiences rebuilding his health using underground tools, why he refuses to ask for permission to take care of his body, and how performance enhancement fits into longevity, metabolism, and real-world function. You'll Learn: • What research chemicals actually are and why peptides fall into that category • How compounds like MK-677 stimulate growth hormone and affect muscle and recovery • Why SARMs differ from steroids and where the real risks come from • The difference between tobacco and nicotine and why low-dose nicotine can support brain optimization • How performance enhancement fits into longevity, metabolism, and functional medicine thinking • Why strength and neurological drive matter more than size alone • How to think clearly about supplements, nootropics, and biohacking tools without fear or hype • Why taking responsibility for your biology is not cheating Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! • Antarctica Trip | Join me in Antarctica from March 8–17, 2026. Visit https://www.insiderexpeditions.com/future and use code DAVE for $1,000 off. • AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. • STEMREGEN | Go to https://stemregen.co/dave30 and use code DAVE30 for 30% off your next order. • Our Place | Visit https://fromourplace.com/DAVE and use code DAVE for 10% off sitewide. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: biohacking research chemicals, peptide biohacking podcast, underground peptides, SARMs explained, MK-677 growth hormone, performance enhancing drugs science, human performance biohacking, longevity biohacking podcast, neuroplasticity optimization, brain optimization nootropics, mitochondrial optimization biohacking, metabolism and hormones, testosterone optimization science, nicotine brain benefits, modafinil cognitive performance, supplements biohacking debate, functional medicine biohacking, muscle vs strength science, anti-aging performance strategies, Dave Asprey biohacking, Dylan Gemelli biohacking, The Human Upgrade podcast, Smarter Not Harder biohacking Resources: • Learn More About Dylan's Work And Content At: https://dylangemelli.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 1:28 - SARMs & Research Chemicals 7:43 - 29 Pounds of Muscle in 6 Weeks 10:20 - MK-677 & Growth Hormone 16:41 - Vegan Diet Disaster 18:30 - From Bodybuilding to Biohacking 21:31 - Diet Transformation & Metabolism 29:14 - Reversing Heart Plaque 33:50 - Exercise, Cardio & Longevity 44:16 - Testosterone, TRT & Kyzatrex 50:06 - Healthcare Freedom 53:23 - Medical Freedom See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Key Takeaways: Integrity Always Wins: In business, truth builds over time, while shortcuts and distortions eventually fall apart. Operating with honesty creates stronger and more lasting results. Get Reliable Tax Advice: Taxes are complex. It's better to rely on qualified professionals than social media tips that can be incomplete or misleading. Know Your Numbers: Regularly reviewing your finances and being transparent about performance helps you spot problems early and grow with confidence. Plan Based on Reality: Strong businesses are built on clear facts, not wishful thinking. Making decisions grounded in reality leads to steady progress. Build for the Long Term: Focusing on long-term relationships and smart financial systems creates stability and sustainable growth over time.   Chapters: 0:00 Truth Compounds While Lies Collapse Over Time 1:25 Avoiding Tax Advice From TikTok 2:27 Honesty and Optimism in Entrepreneurship 4:34 Balancing Tax Obligations and Investment Strategies 7:45 Building Strong Business Foundations for Long-Term Success 9:26 Decision-Making Anchors for Business Success Powered by ReiffMartin CPA and Stone Hill Wealth Management   Social Media Handles    Follow Phillip Washington, Jr. on Instagram (@askphillip)   Subscribe to Wealth Building Made Simple newsletter https://www.wealthbuildingmadesimple.us/   Ready to turn your investing dreams into reality? Our "Wealth Building Made Simple" premium newsletter is your secret weapon. We break down investing in a way that's easy to understand, even if you're just starting out. Learn the tricks the wealthy use, discover exciting opportunities, and start building the future YOU want. Sign up now, and let's make those dreams happen!   WBMS Premium Subscription   Phillip Washington, Jr. is a registered investment adviser. Information presented is for educational purposes only and does not intend to make an offer or solicitation for the sale or purchase of any specific securities, investments, or investment strategies. Investments involve risk and, unless otherwise stated, are not guaranteed. Be sure to first consult with a qualified financial adviser and/or tax professional before implementing any strategy discussed herein. Past performance is not indicative of future performance.

Juanita Headley is the advocacy & communications representative at the Global Anti-Scam Organization. She is also an anti-trafficking advocate, human rights executive, and TEDx Speaker. In this episode, Headley joins host Chris Morgan to discuss scam compounds in Southeast Asia, the tactics traffickers use to lure victims inside, bringing cybercriminals to justice, and more. To learn more about the Global Anti-Scam Organization, or GASO, visit https://www.globalantiscam.org. • For more on cybersecurity, visit us at https://cybersecurityventures.com.

1154. This week, we look at "headless" nouns like "scarecrow," "pickpocket," and "breakfast." We look at why these "cutthroat compounds" break the normal rules of English grammar. Then, we look at the science of reading versus listening, including how our brains process text differently from audio and why multitasking can affect your comprehension.

After exposing the scam compounds and human trafficking behind today's fraud economy, we follow the money, the power, and the few pressure points—from crypto seizures to sanctions—that might actually help spell the end of Southeast Asian scam compounds. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today's story: Southeast Asia has become the global hub of online scams, where scammers in massive compounds target workers around the world. China and the United States have begun pressuring governments in the region to shut down the scam compounds. But it's still not clear if these efforts will make a difference. Transcript & Exercises: https://plainenglish.com/833Get the full story and learning resources: https://plainenglish.com/833--Plain English helps you improve your English:Learn about the world and improve your EnglishClear, natural English at a speed you can understandNew stories every weekLearn even more at PlainEnglish.comMentioned in this episode:Hard words? No problemNever be confused by difficult words in Plain English again! See translations of the hardest words and phrases from English to your language. Each episode transcript includes built-in translations into Spanish, Portuguese, Chinese, German, French, Italian, Japanese, Polish, and Turkish. Sign up for a free 14-day trial at PlainEnglish.com

Dr. Don and Professor Ben talk about the risks of consuming 44 year old wine stored upright. Dr. Don - not risky

You've seen the scam texts. This week we go inside a global scam economy to expose human trafficking networks, lawless economic zones, and fortified compounds where victims are forced to target victims in a world of crime bosses and corrupt politicians. Learn more about your ad choices. Visit megaphone.fm/adchoices

Mood, motivation, and emotional resilience are not personality traits. They are biological systems. In this episode, you'll get the 12 greatest mood boosters on Earth, not as a clickbait supplement list, but as the real biological levers that control dopamine sensitivity, hormones, neuroplasticity, and energy production.Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down in Dubai with friend of the show, Lucas Aoun, founder of Ergogenic Health and INB4, for a deep, experience driven conversation on dopamine, mood, and performance. Lucas is Australia's leading biohacker, now based in Dubai, with a background in exercise science, naturopathy, and pharmacology. He is globally recognized for his work in dopamine regulation, testosterone optimization, and neurohormonal performance, and for rigorously testing protocols before recommending them. Together, Dave and Lucas explore how dopamine receptor upregulation changes motivation, mood, and resilience more effectively than stimulants alone. They break down compounds and systems discussed in the episode including solbutiamine, lithium orotate, sarcosine, inositol, uridine, testosterone, growth hormone, ketamine pathways, thyroid optimization, liver health, sleep quality, and desire regulation. The conversation also examines GLP-1 drugs, why they can blunt motivation, and how to think more strategically about long term mood and energy. This episode connects neuroscience, functional medicine, hormone biology, nootropics, and advanced biohacking ethics into a single framework for improving how you feel and function every day. Dave and Lucas also explain why experimentation requires guardrails, how to avoid tolerance and emotional flattening, and why upgrading baseline biology beats chasing quick fixes. You'll Learn: • Why dopamine sensitivity matters more than dopamine levels • How mood, motivation, and desire are regulated biologically • Which compounds and systems came up as major mood levers • How testosterone and growth hormone influence emotional resilience • Why some longevity drugs may reduce motivation and drive • How sleep depth and mitochondrial function affect mood • The role of neuroplasticity in emotional regulation • Why strategic testing beats random supplementation • How to improve mood without addiction or burnout • Where to start if you want sustainable energy and motivation Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! -LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. -Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. -AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: dopamine sensitivity, dopamine receptors, mood boosters, motivation biology, dopamine supplements, natural mood boosters, biohacking dopamine, emotional resilience, anhedonia dopamine, focus and motivation, testosterone mood, growth hormone mood, ketamine alternatives, neuroplasticity mood, sleep and mood regulation, mitochondrial energy mood, GLP-1 dopamine effects, desire regulation, hormone optimization mood, dave asprey dopamine, lucas aoun biohacking, smarter not harder mood Resources: • Lucas's YouTube: https://www.youtube.com/c/boostyourbiology/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Introduction & Dopamine Discussion 2:55 – Dopamine Compounds 6:29 – Lithium & Emotional Regulation 9:37 – Pain, Suffering & Biohacking Ethics 13:56 – Trumpet Vine & Amphetamine Alternatives 17:55 – Nootropics & Experimentation 20:27 – Sarcosine & Fast-Acting Antidepressants 23:53 – Sugar Tolerance & Inositol 27:01 – Testosterone & Hormone Optimization 33:48 – Natural Testosterone Optimization 37:36 – Anabolic Agents & SARMs 39:38 – Growth Hormone & MK-677 40:38 – Cabergoline & Prolactin 49:03 – Thyroid & Reverse T3 51:18 – Liver Health & Tudca 54:53 – Ketamine & Psychedelics 1:02:01 – Experimental Compounds 1:07:05 – Advanced Peptides & Compounds 1:13:19 – GLP-1 Agonists & Dopamine 1:14:44 – Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

https://www.jayfeldmanwellness.com/healthy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/non-toxic-product-recommendations-for-your-home-body-cookware-skincare-clothing-emfs-more/   Timestamps: 0:00 – intro  0:53 – misconceptions regarding the Randle cycle in the alternative health world  4:57 – what is the Randle cycle?  7:06 – what most people get wrong about the Randle cycle  10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio  16:29 – how fat oxidation inhibits the utilization of carbohydrates  21:03 – the Randle cycle shows the benefits of burning carbs for energy  25:56 – how fat oxidation inhibits the utilization of carbohydrates cont'd  26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging  32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization  38:39 – how glucose oxidation inhibits the uptake and utilization of fats  45:32 – whether you can “activate” or “deactivate” the Randle cycle  47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production  52:08 – the protective effects of CO2 and why the brain can't use fats as a fuel  53:17 – whether we should strive for metabolic flexibility  55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing  1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state  1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle?  1:08:08 – different cells, tissues, and organs can use different fuels at the same time   

Send us a text if you want to be on the Podcast & explain why!Ready to stop spinning your wheels and start training like your results matter? We take a classic bro split from a young lifter who wants bigger arms and less fat, then rebuild it into a focused, tension-first plan that actually moves the needle. The fix isn't more fluff—it's better sequencing, smarter volume, and a weekly structure that balances heavy work with strategic accessories.We start by clearing the biggest bottleneck: too much isolation too early. Compounds go first to drive strength and mechanical tension; isolation slides to the end where it belongs. Using a simple CCA pattern—compound, compound, accessory—we stack pressing and rowing for output and then add targeted raises, curls, and triceps work that won't blunt your main lifts. Along the way, we address common pitfalls like fragile low backs during bent-over rows, shoulder irritation on fixed-path incline pressing, and calf training that never progresses beyond 3x10.Progression gets an upgrade with daily undulating periodization. One day leans heavy in the 5–8 rep zone, the next expands to 8–12 or 10–15 for volume and skill. We outline weekly set targets, show how to nudge volume 10–20 percent without tipping into junk fatigue, and explain why tension is the north star while stress and damage remain useful indicators. You'll also hear how to use short, brutal finishers—push-ups, pull-ups, walking lunges—to add conditioning, and how interval runs beat endless steady-state when the goal is fat loss with muscle retention.By the end, you'll know how to structure a chest-forward day, a back-dominant day, and an optional leg or accessory day that respects recovery and keeps elbows and shoulders happy. You'll leave with a plan to grow faster, get stronger, and ditch random workouts for training with a purpose. If this helps, follow the show, share it with a training partner, and drop a review telling us which lift you're prioritizing this month.Want to become a SUCCESSFUL personal trainer? SUF-CPT is the FASTEST growing personal training certification in the world! Want to ask us a question? Email info@showupfitness.com with the subject line PODCAST QUESTION to get your question answered live on the show! Website: https://www.showupfitness.com/Become a Successful Personal Trainer Book Vol. 2 (Amazon): https://a.co/d/1aoRnqANASM / ACE / ISSA study guide: https://www.showupfitness.com

Keith discusses the K-shaped economy, where income from capital assets is rising while labor income is declining.  In 1965, 50% of income came from labor and 50% from capital; by 1990, it was 54% and 46%, respectively, and today it's 57% and 43%. Keith emphasizes the importance of how capital compounds over labor and advises on building ownership in real estate and businesses.  Finally, he answers your listener's questions about: agricultural real estate inflation, profiting on mortgage loans, transitioning from accumulation to preservation and a fast-growing state that no one talks about. Episode Page: GetRichEducation.com/584 For access to properties or free help with a GRE Investment Coach, start here: GREmarketplace.com GRE Free Investment Coaching: GREinvestmentcoach.com Get mortgage loans for investment property: RidgeLendingGroup.com or call 855-74-RIDGE  or e-mail: info@RidgeLendingGroup.com Invest with Freedom Family Investments.  For predictable 10-12% quarterly returns, visit FreedomFamilyInvestments.com/GRE or text  1-937-795-8989 to speak with a freedom coach Will you please leave a review for the show? I'd be grateful. Search "how to leave an Apple Podcasts review"  For advertising inquiries, visit: GetRichEducation.com/ad Best Financial Education: GetRichEducation.com Get our wealth-building newsletter free— GREletter.com or text 'GRE' to 66866 Our YouTube Channel: www.youtube.com/c/GetRichEducation Follow us on Instagram: @getricheducation Complete episode transcript: Keith Weinhold  0:00   Keith, welcome to GRE. I'm your host. Keith Weinhold, capital compounds, labor doesn't realizing this can change allocation decisions for the rest of your life. Then I discuss giving. Finally, I answer your listener questions about agricultural real estate inflation, profiting on mortgage loans when it's time for you to stop accumulating properties and a fast growing state that no one talks about today on get rich education   Speaker 1  0:33   since 2014 the powerful get rich education podcast has created more passive income for people than nearly any other show in the world. This show teaches you how to earn strong returns from passive real estate investing in the best markets without losing your time being a flipper or landlord. Show Host Keith Weinhold writes for both Forbes and Rich Dad advisors, and delivers a new show every week since 2014 there's been millions of listener downloads of 188 world nations. He has a list show guests include top selling personal finance author Robert Kiyosaki, get rich education can be heard on every podcast platform, plus it has its own dedicated Apple and Android listener phone apps build wealth on the go with the get rich education podcast. Sign up now for the get rich education podcast or visit get rich education.com   Corey Coates  1:18   You're listening to the show that has created more financial freedom than nearly any show in the world. This is get rich education.   Keith Weinhold  1:34   Welcome to GRE from Williamsburg, Virginia to Williamsport, Pennsylvania and across 188 nations worldwide. I'm Keith Weinhold, and you're listening to get rich education, and I'm somewhat near Williamsport, Pennsylvania today. For years, I've told you about the widening canyon between the haves and the have nots, and that's something that you might have only visualized in your head or merely considered a theory, but now you can see it. There's a chart that I recently shared with our newsletter subscribers that might just make your spine tingle and look, I don't like saying this, but hard work just does not pay off like it used to. This is emblematic of the K shaped economy. Just visualize the upper branch of the K, a line rising over time, and the lower branch of a letter k, that line falling over time, both plotted on the same chart. So what steadily happened over the last 60 years really is quite astonishing. And look, I don't want the world to be the way that I'm about to tell you it is, but that's just what's occurring. The share of one's income from capital assets is rising, while the share from labor keeps decreasing simultaneously. Now just think about your own personal economy. What share of your income is from your invested capital versus how much of your income is derived from your labor. When you're the youngest, it's all labor. When I got out of college and had my first job, all of my income was from labor. I certainly didn't have any rental property cash flow or stock dividends. But for Americans, here is how it's changed over time, and this K shaped divergence is alarming people in 1965 it was 5050 by 1990 54% of income was from capital and 46% labor. Today it's 57% capital and only 43 labor. Gosh, the divergence is real, and it's only getting wider, and I really had to dig for the sources on this K shaped economy chart. They are the BLS, the Tax Foundation and the International Labor Organization. Increasingly, asset owners are the haves. The upper part of this K shaped economy, that line is drifting up like a helium balloon that you forgot to tie to the chair. It just keeps going up and then the labor share of income, which is shrinking, that is also known as how much of the economic pie goes to people who actually work for a living. That is another way to think of it. So frankly, that's why I say hard work just does not pay off like it used to, because with each wave of inflation, assets, pump, leveraged assets, mega pump and wages lag behind, and we can't allocate our resources in the way that we want the. World to be, but how the world really is. In fact, the disparity is even greater than the chart that I just described to you, because it doesn't even include value accumulation, also known as appreciation. I was only talking about income there, and the reality is that working for a paycheck just pays off less and less and less. No amount of working overtime on a Saturday can make you wealthy, but it might make you miserable. Owning assets pays off more and more. In fact, the effect is even more exaggerated than what I even described, because, as we know, the tax treatment is lighter on your capital gains than it is your income derived through labor. As the economy keeps evolving, those who benefit the most, they do not sell their time for money. They're not trading their time for dollars. In fact, let me distill it down here are, yeah, it's just four words that could change the way you allocate your time and your effort for the rest of your life. Capital compounds, labor doesn't. yeah, there's a lot right there. If you want to keep up or get ahead, you need to be on the capital part of the K, the upper part. And what would that really look like for you in real life? What does that practically mean? It means building ownership into your financial life, owning real estate, owning businesses using prudent leverage, owning things that produce income, and even merely owning more things that appreciate. And here's the great news, though, real estate is still the most accessible, leverageable, tax favored capital friendly asset class ever created. That's whether you're just patching together like 43k for a down payment on your first turnkey single family rental, or making a tax deferred exchange into a 212 door apartment complex. Okay, this is how that can look in real life. The bottom line here is that as the economy gets more and more K shaped, with this divergence between Americans capital share of income increasing and labor share decreasing, that you want to stack real income generating assets. That is the big takeaway.    Keith Weinhold  7:44   Well, this is the time of year where a lot of people feel compelled to give donations. And as a GRE listener that's paid five ways, you've got more ability than others to give, I need to caution you about some things. I'm sorry that it is this way, because I do want to promote giving. It's kind, it's virtuous, and it's not a completely selfless act either, because when I give, it makes me feel good too. You're making a difference, and that feels great. Let's talk about the downsides of giving, though, because few people discuss that. We already know about the upsides when I give to an organization, say, 1500 bucks here, $1,000 over there, well, inevitably, you do get on that organization's contact list. And yeah, I suppose that it is easier to retain a customer or donor than it is to find a new one. Sometimes I just make what I expected to be a one time donation, but they will keep contacting you. Now, I was once on the other side of this. I served on a volunteer committee that organizes athletic events, and a friend of mine, John made a $1,000 donation to our organization one year, which was really kind, and he's just a day job working kind of guy when he didn't make the donation. The following year, someone made it a line item in our meeting minutes to say that John's donation was not renewed. Like that's the only thing they brought up. Oh gosh, that really struck me the wrong way, because here's a guy that traded his time for dollars at a job that I happen to know he doesn't like very much, and the committee statement was that the guy didn't renew his donation. Sheesh, now, when it comes to the tax treatment of, say, $1,000 that you make in a donation, there's a lot of misunderstanding about how that works, and this is the type of subject that you're thinking about now, because sometimes people want to get a tax break tallied up before year end, because some people think that after the year ends, well, the IRS pays you back the $1,000 you donated because it's tax deductible. No, that's how a tax credit. Works. But a tax deduction, which is all that you might be eligible for, means that if your annual income is 100k well then a 1k donation lowers your taxable income to 99k so if you're in the 24% tax bracket, then you'd get 240 bucks back. But you know, in many or even most cases, you're not going to get any tax break at all for making a donation, and this is because you did not exceed the standard deduction threshold, which is now almost 16k if you're single and almost 32k married, you get to deduct those amounts from your taxable income no matter what. So the standard deduction, in a way, it's nice, because you don't have to keep receipts and do all that tracking for everything. So I've had that experience myself where, huh, feeling a little generous throughout the year, giving $1,500 here, $1,000 there. Oh, and then realizing that it does nothing for me on taxes, you have to give more to exceed the standard deduction amount and start itemizing them. And mortgage interest does go into that amount. Okay, it does go into the amount to try to get your total above the standard deduction threshold. So go ahead and give freely, but in a lot of cases, keep in mind that it often does nothing for your taxes, because you're taking that standard deduction if you indeed are. There's been another tip flation trend that's annoying, and that is increasingly when I give a donation online, I'm asked to if I want to leave a tip on top of the donation. That is so weird, a tip is for good service. I'm serving you by being generous enough to give a donation. Sheesh, a tip request on top of a donation. But please do give when you do, one thing that you might want to specify is that it is a one time donation, if that is your intent, or they will constantly follow up with you.    Keith Weinhold  12:06   Coming up next, I'm going to answer your listener questions. A member of Team GRE, who you haven't heard before, is going to come in to ask me your listener questions, and one of them is going to be among the most important topics that our show has never addressed, and it's about time. I'm Keith Weinhold. You're listening to get rich education.    Keith Weinhold  12:28   You know, most people think they're playing it safe with their liquid money, but they're actually losing savings accounts and bonds don't keep up when true inflation eats six or 7% of your wealth every single year I invest my liquidity with FFI freedom family investments in their flagship program. Why fixed 10 to 12% returns have been predictable and paid quarterly. There's real world security backed by needs based real estate like affordable housing, Senior Living and healthcare. Ask about the freedom flagship program when you speak to a freedom coach there, and that's just one part of their family of products, they've got workshops, webinars and seminars designed to educate you before you invest. Start with as little as 25k and finally, get your money working as hard as you do. Get started at Freedom, family investments.com/gre, or send a text now it's 1-937-795-8989, yep, text their freedom coach, directly again, 1-937-795-8989   Keith Weinhold  13:40   the same place where I get my own mortgage loans is where you can get yours. Ridge lending group and MLS, 42056, they provided our listeners with more loans than anyone because they specialize in income properties. They help you build a long term plan for growing your real estate empire with leverage. Start your prequel and even chat with President Caeli Ridge personally while it's on your mind, start at Ridge lending group.com that's Ridge lending group.com   Kristen Tate  14:14   this is author Kristin Tate. Listen to get rich education with Keith Weinhold, and don't quit your Daydream.   Keith Weinhold  14:32   Welcome back to get rich Education. I'm your host. Keith Weinhold, they say that it takes a village to get some things done and well, it takes a team to prop up this slack jawed operation one GRE team member, capably behind the scenes for more than a year and a half now, is Brenda Almendariz, welcome in. Brenda, Hi, Keith, thanks. Rather than me asking the listener questions this time you. You get to do it, but before we do that, just tell us a bit about your real estate investing.    Brenda  15:07   Sure. So I started maybe learning a little bit about investing and kind of looking into other options to grow my wealth. And I came across the GRE podcast and a few others. So I think about 2018 I did a little bit of just learning and kind of educating myself. And then 2019 I bought my first turnkey property. Turned out well. And then 2020 I bought my second one. And then in 2021 I decided, okay, this is working really well. Maybe I'll do a house hack. I'll do something a little different, and in a year, then maybe I'll do something else. But I've been in my 2021 home now for about almost five years. I'm looking for the next one, hopefully within the next year. But yeah, it's been great. Turnkey. Just met real estate investment company here at my local REIA, and then I learned that I could actually connect with other companies across other places through GRE but yeah, it's been great.   Keith Weinhold  16:02   Brenda lives in Phoenix, just about as close to the center of Phoenix as you can possibly be. I sat down with Brenda for lunch the last time that I was in Phoenix, and like a lot of people, almost everybody that works here at GRE they started out as a listener before they ever worked here. And really, it's that same story with Brenda as well. So yeah, Brenda will want to ask us the first of what we have about four listener questions today   Brenda  16:31   we do, so I'll go over the first one here. Question is, I would love for you to revisit some of the non traditional example, coffee plantation, CBD manufacturing, teak plantation, Belize resort properties and syndication projects you've discussed on the GRE podcast just to see how they turned out. I'm sure some of them failed to deliver the expected returns, and it's the failures that many of us learn the most from   Keith Weinhold  17:02   Yeah, totally. Okay, so not so much a listener question here, but a comment to discuss more of these agricultural real estate investments or ones that are in syndications off of the investment type that you can't do yourself, is what we're talking about here, rather than direct ownership of residential rental property and an appeal to follow up down the road to see how they really turned out. And you know, Brenda, I'll address you because we don't have the listener name with this question. Most people in my position, if an investment has been discussed on the show, and then that investment didn't go as well as was hoped for, you know what? They never tell the audience about it. However, there's the Panama coffee farm investment. We first discussed that here way back in 2015 and we had a GRE field trip where I met a lot of you in person there in Panama. And as I often do when we discuss a particular investment here, I bought and still own Panama coffee farm parcels myself. That investment, it paid cash flow from the crop yields for a few years, and then it stopped. The good yields stopped due to covid disruption, and since then, there have also been erratic weather patterns like drought and precipitation of the wrong levels and at the wrong time of year, and there's been more of a prevalence of pests in disease like coffee leaf, rust and the operator. They have been communicative and forthcoming all the while they're still issuing the annual report that I read, and sometime after that, I think that a lot of investors were assured, because it sort of made national news, international news, that markets for both coffee and cacao have been suppressed, at least from the standpoint of there's not enough crop yield. I mean, that is a problem in a lot of places worldwide. Now I hope that turns around, and it very well may. In fact, we did something here that very few shows do. Back on episode 431, we had the Panama coffee farm CEO come back on the show to describe exactly what I just told you about there. And few shows are willing to do that. Some people just want you to think that every single investment that's discussed goes as well it was hoped for, or even better than expected. But that is not real world. You got to be authentic in real So, okay. Listener, comment, well, taken there. They appreciate that sort of follow up, and they would like more of that. All right, that's great. What's the next question? Brenda.   Brenda  19:40   Sure. So the next one comes to us from our audience over on YouTube. So in response to our real estate pays five ways in a slow market, YouTube video matrices wrote, There is no inflation profiting. You would have to be paying off the loan with an income that goes up with housing inflation. That's plausible if you are a wage earner, but if your source of income is rental properties, then there isn't a wage increase that reduces the effective loan amount. You are double dipping in the inflation profiting column by counting appreciation which you earn as a real estate investor and inflation profiting, which you earn only if your wages go up at the rate of housing inflation, and you use those wages to pay off the loan, which you don't   Keith Weinhold  20:33   Okay, again, somewhat of a statement here. I suppose there's a question implicit within that for matrices. I'm not sure how you say that name exactly. Wondering about inflation profiting. Are you counting it? Right? I don't know about that. The part about paying off the loan faster if you're a wage earner, I mean, that's plausible, but not if your income is from rental properties. I mean, see that's actually backwards, because your cash flow goes up faster than the rate of inflation due to your biggest payment, your principal and interest staying fixed, so your net rent income goes up even faster than the rate of inflation. So inflation profiting, therefore it's even better than how I've been presenting it and calculating it. Now with that understood matrices, here's one way for real estate investors to understand inflation profiting on your loan if you still have trouble getting with that. 30 years ago, in 1995 the US median home price was 130k with an 80% loan, your mortgage balance at origination would have been 104k and the monthly mortgage payment is 763 with the 8% market mortgage rate level that you would have gotten at that time. Now, even if we don't apply any principal pay down at all, your mortgage balance today is still just 104k and your payment is still just 736 bucks, and it is substantially easier to make that payment today, because your wages and salaries and rent incomes are multiples higher. When you originate a loan, the bank doesn't ask to be repaid in dollars or their equivalent. The loan documents only say dollars and dollars are worth less and less and less. So today, your median priced property is worth over 400k despite still having that tiny 104k loan balance. And of course, your tenant would have paid that down to zero, and we aren't even counting that part, I think, to really exaggerate the effect and help make the inflation profiting concept crystallize for you, matrices. If you go back 100 years, the median home cost was 11,600 bucks. An 80% loan would be just over 9k that you borrowed. Okay, so at a 7% interest rate, 30 year loan, the monthly payment would be 94 bucks, laughably small. That's less than the cost of a nice dinner out today. That's all you owe on a median priced property, which is over 400k today. So because it doesn't feel like you're tangibly walking away with anything when you sell a property, hopefully that helps make it real mitricas. And one last way to think about it is, let's just forget real estate for a moment. Would you loan your best friend 100k for 30 years interest free, even if we're somehow absolutely guaranteed that he would pay you back? Well, of course, he wouldn't do that, because inflation destroys the lender and benefits the borrower. So you would want to be the borrower in that case, because the borrower profits from inflation, profiting just like you're the borrower with income property. That's the position that you want to be in. But I'm glad we brought this up, because a lot of people have that question. That was a good one. Matrices, even though you seem to sort of be doubting if inflation profiting is a real thing with the way you approach the question, hey, I really appreciate it. Anyway, what's the next one? Brenda   Brenda  24:10   yep. So the next one we have is Mark. He wrote into our general inbox, and he says, I have been listening to your podcasts from the beginning, and I believe I have not missed a single show. Wow. Yeah, it would be hard to argue with your strategy of using debt to rapidly increase your returns and expand your rental real estate portfolio. This method is great for the accumulation phase of one's life. However, I believe that you have never addressed the next chapter of everyone's life, phase two. I am, of course, talking about preserving your wealth, which is phase two. Yeah, I only ask this because that is what stage of life I am in. For background, he has 15 rentals, seven mortgages. Age 62. Currently all managed by a property manager, and he is married and an empty nester. Please note, no matter how much money is made from rentals, he said, his wife's view is that it is work, and so she does not want any more homes or work. This would be a great idea for an upcoming show. Please consider thanks, Mark.   Keith Weinhold  25:20   Yeah. Great stuff, Mark. And before Brenda came on, we discussed which questions that she's going to choose. And I definitely wanted to have this one in there, because, I mean, this is one of the most important topics that's never been answered on the show, and it really needs to be answered today. The accumulation phase of Mark's life is done. He wants to know about how to approach the preservation stage. First of all, Mark, congratulations. You've listened to every GRE episode, 584, of them now, and you've clearly benefited from acting so good for you to be in this position. In fact, this show had its inception in 2014 and it doesn't even take these 1011, years to reach financial freedom, if you follow my plan. So you are there. All right, so, Mark, you've got 15 rentals, seven mortgages. You're age 62 they're currently managed by a property manager. You're married in an empty nester. I mean, you've made it, and you know that you've made it when you have enough income to support your desired lifestyle. That's what we're talking about here. Financially Free, beat step free and all of that, I'm going to speculate mark that if you had tried paying all cash for every property, you wouldn't have gotten very far. You wouldn't have made it to this point. You know why this question resonates so well with me, Mark, despite being quite a bit younger than you, I am at that stage as well. I definitely don't need to add more properties for the rest of my life. Now. I don't have kids yet either, so there's no clear air there. In fact, one reason that I hold on to my properties is to help educate our audience to be a real investor in the game and to be able to keep up with trends. You can just kind of tell when someone's not investing in real estate themselves. So if I talk it, I want to keep doing it now for you, Mark, it's not about rushing to pay off your seven mortgages, as you know from listening, that's usually not your best return on capital. If you've already made it, there is absolutely zero reason to add more properties, I would agree, especially if you know, in your wife's eyes, that creates a headache, and maybe yours as well, once you get to a certain point. So as far as this preservation stage, since you've moved away from the accumulation phase, the LLC is the favorite protection structure, not a C or an S Corp. And I have done shows on that with attorneys before. Since I'm not one of your 15 properties, if one or two are less profitable or for whatever reason, you just have difficulty getting those rented during vacancies, okay, you can sell those off if you don't want to do the 1031, exchange into more property, you can pay the tax. That's an option, but you will also have to pay depreciation recapture on those properties and mark. If there's one thing I wish I knew, it's that if you do have children or clear heirs, but the gold standard for passing along properties to heirs is a revocable living trust, and if you only remember one thing about that, a properly drafted living trust is the number one way to pass along rental properties smoothly. And why it's great is that it avoids probate. Probate is a court supervised process. It takes months or years of delay. So instead, with a revocable living trust, heirs get access to your properties almost immediately. Now you are age 62 hopefully this isn't happening anytime soon, but you do keep full control while you're alive, it's easy to update a revocable living trust, but the big one probably is that it prevents family disputes and it keeps everything private. That way there's no public probate record. And the bonus is, if you own properties in multiple states, a trust avoids multiple probates, that's huge. So those are some considerations. Mark as you've Congratulations again. Move from the accumulation phase to the preservation stage. It's a completely normal, natural process. You sure don't have to keep adding properties for ever and ever. Congrats. You made it. You did it.    Brenda  29:37   Great. We've got another one, Keith. This one is from Tim in Philomath, Oregon, and he says, I would be interested in the days ahead, if you would be able to help us understand why North Dakota is projected to grow so much.   Keith Weinhold  29:54   Okay, thanks, Tim in follow math, Oregon, another word I'm not sure how to pronounce. Now, yeah, you might think it's unusual that I would want to answer this question. For a low population state of under 1 million people, like North Dakota, from today to 2050 there's forecast to be 9% population growth nationally, but in North Dakota, it is 34% that is quite a surge, and that is per visual capitalist via the University of Virginia, but North Dakota's projected growth, it looks surprisingly strong on paper, especially for a cold, rural, low population state. But really, there are at least four major forces behind the fast 2025 to 2050, Outlook, and when you break them down, the growth actually makes sense. So I want to talk about this, because it's really a template for what makes for a growing place and a good future real estate market, no matter where it is. But in North Dakota, you've got this continued energy sector, strength, oil, gas and next generation energy. Part of what's driving the growth is something that's definitely not a new story. It is still the Bach and shale. It's still one of the top US oil fields. You got advances in drilling. That means more production with fewer rigs. That makes a sector more resilient. You've got global demand for liquid fuels projected to remain high through 2050 I know people like to talk about renewables, and there probably is a future there. But it's not like we're going to go all renewable right away. North Dakota is aggressively expanding carbon capture. So energy equals jobs. Jobs equals population retention and in migration, there's a national labor shortage in North Dakota. It's got this skilled worker hole. The US is going to face a major labor shortage through 2050 that's because of trends that you really can't change, like an aging population and low birth rates. That makes these high wage, high demand energy and engineering jobs stickier. North Dakota consistently leads in labor force participation, job availability, good starting wages for skilled trades, and they always seem to have a low unemployment rate, lower than the national average. So in other words, people move where the jobs are, even if it's cold. They really have one of the best economic outlooks in the country. There's a report called Rich states, poor states. In their latest one, they ranked North Dakota fifth nationwide in economic outlook, and that's above Texas and Florida and Tennessee, and that's because North Dakota has low taxes. They're business friendly, they're light on regulation. Businesses like that, their budgets are stable, and they've got strong public finances. So states with those fundamentals, they tend to grow pretty well over long horizons, and North Dakota has this demographic momentum. It's a younger state than all the surrounding states. They have a younger median age, high birth rates, so they've got this faster natural replacement rates, and they have really strong university systems, both und and North Dakota State, and what that does is that retains those graduates for jobs like energy and engineering and agriculture. So North Dakota benefits from this high stay rate, like a lot of people move for jobs, and they end up staying there, and their population growth seems fast, but the overall population small, so a net gain of 150,000 people, that really seems huge in percentage terms. It's steady rather than explosive growth. We're talking about annual gain. So really, a takeaway for investors is that North Dakota's growth is not a fluke. It's from strong economic policy, a big, durable energy engine, high earning jobs. You got this favorable business climate, and really unexpectedly young demographics. I read that the counties that will grow fastest are Cass Williams and stark and, you know, Brenda. If we learn about a reputable North Dakota property provider, maybe we'll talk about them here on the show. So if you the listener or anyone else know about one, write into us at get rich education, comm slash contact, and we'll check them out. And also, more broadly, if you want your listener question answered in the future, that's where to write to us as well, again, at get rich education.com/contact, thank thanks for the North Dakota question, Tim and Brenda, it's nice to have you here to ask the questions in a different voice.   Brenda  34:29   Thanks, Keith. Yeah, it's good to be on this side of the show instead of   Keith Weinhold  34:34   a listener. After all these years, there's one episode I'm sure you'll be listening to, and it's this one that you're on today.   Keith Weinhold  34:48   Yeah, much of our team here were GRE listeners before they ever worked here. We just made another hire two months ago. That woman worked for a payment processor. I said at the time, that sounds really boring. It definitely sounds more interesting to work at the GRE podcast. To review what you learned today, capital compounds labor doesn't though I promote being a giver, there are downsides to giving, but they're manageable. Inflation, profiting is the most often misunderstood of the five ways, and you will reach a tipping point where you've won in which you no longer have to add properties. That is transitioning from the accumulation phase to the preservation phase. That is one of the more important unaddressed things on the show until today, and finally, North Dakota's booming growth projections coming up soon on the show, I'll reveal GRE national home price appreciation forecast for next year, where you will learn the exact percent appreciation or decline expected in the future. Until then, check us out at get richeducation.com I'm your host. Keith Weinhold, don't quit your Daydream.   Speaker 3  36:00   You nothing on this show should be considered specific, personal or professional advice. Please consult an appropriate tax, legal, real estate, financial or business professional for individualized advice. Opinions of guests are their own. Information is not guaranteed. All investment strategies have the potential for profit or loss. The host is operating on behalf of Get Rich Education LLC, exclusively.   Keith Weinhold  36:32   The preceding program was brought to you by your home for wealth building, GetRichEducation.com  

This week: 67 days into a ceasefire, Israel has killed at least 383 Palestinians in Gaza.   A winter storm killed at least 14 Palestinians in Gaza. Israel approved further settlements in the occupied West Bank. Israel has killed more than 70,656 Palestinians in Gaza since October 7th, 2023. In this episode: Ibrahim Al Khalili, (@_ibrahimalkhalili) Al Jazeera Correspondent Hind Khoudary, (@Hind_Gaza) Al Jazeera Correspondent Nour Odeh, (@osamabinjavaid) Al Jazeera Correspondent Episode credits: This episode was produced and mixed by David Enders. Our sound designer is Alex Roldan. Our lead of audience development and engagement is Andrew Greiner and Munera AlDosari is our engagement producer. Alexandra Locke is The Take’s executive producer. Ney Alvarez is Al Jazeera's head of audio. Connect with us: @AJEPodcasts on X, Instagram, Facebook, and YouTube

AI advantage is proving to be compounding, not linear. Drawing on new data from OpenAI, Menlo Ventures, EY, and early AI ROI Benchmarking results, this episode explains how leading organizations are pulling away by using AI more intensively, moving beyond time savings into higher-value use cases, and reinvesting gains back into deeper capabilities—creating flywheels that laggards will struggle to catch. In the headlines: real-world AI benchmarks, OpenAI user growth, chip-war intrigue, Oracle earnings, and AI market volatility.Brought to you by:KPMG – Discover how AI is transforming possibility into reality. Tune into the new KPMG 'You Can with AI' podcast and unlock insights that will inform smarter decisions inside your enterprise. Listen now and start shaping your future with every episode. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.kpmg.us/AIpodcasts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Gemini - Build anything with Gemini 3 Pro in Google AI Studio - ⁠⁠⁠⁠http://ai.studio/build⁠⁠⁠⁠Rovo - Unleash the potential of your team with AI-powered Search, Chat and Agents - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://rovo.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠AssemblyAI - The best way to build Voice AI apps - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.assemblyai.com/brief⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LandfallIP - AI to Navigate the Patent Process - https://landfallip.com/Blitzy.com - Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://blitzy.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to build enterprise software in days, not months Robots & Pencils - Cloud-native AI solutions that power results ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://robotsandpencils.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Agent Readiness Audit from Superintelligent - Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://besuper.ai/ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠to request your company's agent readiness score.The AI Daily Brief helps you understand the most important news and discussions in AI. Subscribe to the podcast version of The AI Daily Brief wherever you listen: https://pod.link/1680633614Interested in sponsoring the show? sponsors@aidailybrief.ai

My guest is Dr. David Fajgenbaum, MD, professor of translational medicine and human genetics at the University of Pennsylvania. He explains how, unbeknownst to most doctors, many approved medications can successfully treat or even cure diseases other than the ones they are typically used to treat. He shares his story of escaping death from Castleman's disease by discovering a life-saving treatment using repurposed drugs that were approved for other purposes. Our conversation explores how researchers, physicians, and you—the general public—can explore novel treatments and cures to conditions the medical profession has deemed untreatable, including cancers. We also discuss the crucial role of mindset in battling diseases and the lesser-known use of compounds to promote health and longevity. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman Eight Sleep: https://eightsleep.com/huberman Rorra: https://rorra.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman Timestamps (0:00) David Fajgenbaum (4:06) Self-Agency in Healthcare; New Uses for Old Medicines (6:44) Other Uses of Aspirin & Viagra; Drug Development & Approved Use (8:53) Lidocaine & Breast Cancer; Pharmaceutical Companies & Incentives (11:36) Sponsors: Eight Sleep & Rorra (14:16) Pharmaceutical Companies, Patents & New Uses; Lithium (18:40) Tools: Finding Reliable Health Sources, Asking Questions & Disease Organizations; DADA2 Treatment (21:53) Medical Community & Connections; Integrated Medical Databases (24:36) Drug Repurposing, Thalidomide, Pembrolizumab (28:45) Medical Research Databases, Mapping Disease Connections (33:51) Every Cure Database & Programs, Bachmann-Bupp Syndrome; Colchicine & Heart Disease (37:57) Sponsors: AGZ by AG1 & David (40:41) David's Medical & Career Journey, Glioblastoma, Castleman Disease (49:10) Autoimmune Disease, Driven Personality, Stress & Immune System (52:52) Castleman Disease, Treatment, Chemotherapy (55:54) Physician Continuing Education, Santa Claus Theory of Civilization; Science Collaboration (1:03:32) Medical School, Relapse & “Overtime”, Finding a New Treatment, Rapamycin (1:12:46) Sport, Football & Resilience; Challenge & Personal Growth, Family (1:18:41) Sponsor: Function (1:20:29) Social Support; “Overtime”, Gratitude (1:23:19) Business School, Castleman Disease Treatment; Repurposing Drugs & AI (1:28:29) Drug Repurposing, POEMS Syndrome; Mitigating Risk (1:35:32) Nicotine, Compounds for Preventive Health; GLP-1 Agonists (1:40:51) Bioprospecting, Drug Development; AI, Prioritization & Novel Connections (1:46:18) Healthcare & Children; Hope, Action & Impact Circuit; Challenge & Super-Agers (1:52:50) Get Involved with Every Cure (1:56:20) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

As Vice Week wraps up here at The Indicator, we wanted to take a slightly different perspective on the evolving business of crime and take a look at TRUE crime. As in the genre. Because look, people are obsessed with it! Today on the show, our hosts favorite pieces of true crime content. Darian Woods: The Economist's Scam Inc.Wailin Wong: Wednesday Journal's A tangled mess Adrian Ma: Philadelphia Inquirer's Dime Heist story Related episodes: Fighting AI with AI What's supercharging data breaches? When cartels start to diversify For sponsor-free episodes of The Indicator from Planet Money, subscribe to Planet Money+ via Apple Podcasts or at plus.npr.org. Fact-checking by Sierra Juarez. Music by Drop Electric. Find us: TikTok, Instagram, Facebook, Newsletter. Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy