Podcasts about researching

Systematic study undertaken to increase knowledge

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Latest podcast episodes about researching

Acting Business Boot Camp
Episode 358: What's a Motto With You?

Acting Business Boot Camp

Play Episode Listen Later Oct 8, 2025 10:35


In this episode, I talk about mottos. Those little slogans or mantras that can actually keep you going in a business that is often messy, unpredictable, and overwhelming. A motto is not just decoration. It's a tool. It helps you: Stay grounded when the industry feels chaotic. Filter choices and make better decisions. Communicate your identity and values quickly. Build momentum through small daily actions. I'll share a quick history of mottos, what makes a good one, and a few of my favorites like: Grow through every no Truth over performance Consistent action, creative life Bring light to every role But here's the most important part. A motto has to fuel action. It should connect to something small you can do each day. Even five minutes counts. That could be: Sending one outreach email Researching a casting director Tracking your auditions Posting or reposting content Reviewing your goals When you tie your motto to action, five minutes turns into seven, then ten, and before you know it, you've built momentum. So, here's my challenge for you: Pick a motto tonight. Don't overthink it. Write it down where you'll see it. Tomorrow, spend five minutes on one business task that matches your motto. Repeat. Momentum comes from consistency, not perfection. Your motto isn't just a phrase. It's a compass. Find the one that makes your chest expand a little when you say it out loud, and let it guide your next step. I'd love to hear what motto you come up with. You can always reach me at mandy@actingbusinessbootcamp.com, or say hi on TikTok @AstoriaRed.

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers
833: Researching Alternative Splicing for Gene Regulation in the Immune System - Dr. Kristen Lynch

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

Play Episode Listen Later Oct 6, 2025 37:38


Dr. Kristen Lynch is a Professor and Chair of Biochemistry and Biophysics at the University of Pennsylvania. Kristen's research focuses on alternative splicing. Her lab is investigating how cells decide when to use an entire portion of the DNA instruction manual versus when to exclude parts of the instructions that are not useful or would be harmful. In particular, Kristen is interested in alternative splicing in the immune system and what happens when cells are faced with an immune challenge. When she's not at work, Kristen loves being outdoors. She spends her free time kayaking, paddle boarding, biking, hiking, and doing yoga. She received her B.A. in biochemistry and her Ph.D. in biochemistry from Harvard University. Afterwards, Kristen pursued postdoctoral training at the University of California, San Francisco. She served on the faculty at the University of Texas Southwestern Medical Center prior to joining the faculty at the University of Pennsylvania in 2009. Kristen is the recipient of many awards and honors for her work, including a National Science Foundation CAREER Award. She joined us for an interview to talk about her experiences in life and science.

New Books Network
Michael Rowe, "Researching Street-Level Bureaucracy: Bringing Out the Interpretive Dimensions" (Routledge, 2024)

New Books Network

Play Episode Listen Later Oct 1, 2025 40:09


Researching Street-level Bureaucracy: Bringing Out the Interpretive Dimensions (Routledge, 2024) is the first among a number of new titles in the Routledge Series on Interpretive Methods that we'll be featuring on New Books in Interpretive Political and Social Science. In it, Mike Rowe discusses the continued relevance of the idea of street level bureaucracy, and the merits of adopting interpretive methodologies for studying frontline discretionary workers. He reflects on his own ethnographic and interview-based research among social welfare officers and police culture in the United Kingdom, and comparatively, in places where bureaucracy may be noteworthy more for its absence than its presence.  Like this episode? You might also be interested in Sarah Ball talking about Behavioural Public Policy in Australia Looking for something to read? Mike recommends In Praise of Floods by James C. Scott, and Then We Came to the End by Joshua Ferris.  This interview summary was not synthesised by a machine. Unlike the makers and owners of those machines, the author accepts responsibility for its contents. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

New Books in Political Science
Michael Rowe, "Researching Street-Level Bureaucracy: Bringing Out the Interpretive Dimensions" (Routledge, 2024)

New Books in Political Science

Play Episode Listen Later Oct 1, 2025 40:09


Researching Street-level Bureaucracy: Bringing Out the Interpretive Dimensions (Routledge, 2024) is the first among a number of new titles in the Routledge Series on Interpretive Methods that we'll be featuring on New Books in Interpretive Political and Social Science. In it, Mike Rowe discusses the continued relevance of the idea of street level bureaucracy, and the merits of adopting interpretive methodologies for studying frontline discretionary workers. He reflects on his own ethnographic and interview-based research among social welfare officers and police culture in the United Kingdom, and comparatively, in places where bureaucracy may be noteworthy more for its absence than its presence.  Like this episode? You might also be interested in Sarah Ball talking about Behavioural Public Policy in Australia Looking for something to read? Mike recommends In Praise of Floods by James C. Scott, and Then We Came to the End by Joshua Ferris.  This interview summary was not synthesised by a machine. Unlike the makers and owners of those machines, the author accepts responsibility for its contents. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/political-science

New Books in Anthropology
Michael Rowe, "Researching Street-Level Bureaucracy: Bringing Out the Interpretive Dimensions" (Routledge, 2024)

New Books in Anthropology

Play Episode Listen Later Oct 1, 2025 40:09


Researching Street-level Bureaucracy: Bringing Out the Interpretive Dimensions (Routledge, 2024) is the first among a number of new titles in the Routledge Series on Interpretive Methods that we'll be featuring on New Books in Interpretive Political and Social Science. In it, Mike Rowe discusses the continued relevance of the idea of street level bureaucracy, and the merits of adopting interpretive methodologies for studying frontline discretionary workers. He reflects on his own ethnographic and interview-based research among social welfare officers and police culture in the United Kingdom, and comparatively, in places where bureaucracy may be noteworthy more for its absence than its presence.  Like this episode? You might also be interested in Sarah Ball talking about Behavioural Public Policy in Australia Looking for something to read? Mike recommends In Praise of Floods by James C. Scott, and Then We Came to the End by Joshua Ferris.  This interview summary was not synthesised by a machine. Unlike the makers and owners of those machines, the author accepts responsibility for its contents. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/anthropology

New Books in Sociology
Michael Rowe, "Researching Street-Level Bureaucracy: Bringing Out the Interpretive Dimensions" (Routledge, 2024)

New Books in Sociology

Play Episode Listen Later Oct 1, 2025 40:09


Researching Street-level Bureaucracy: Bringing Out the Interpretive Dimensions (Routledge, 2024) is the first among a number of new titles in the Routledge Series on Interpretive Methods that we'll be featuring on New Books in Interpretive Political and Social Science. In it, Mike Rowe discusses the continued relevance of the idea of street level bureaucracy, and the merits of adopting interpretive methodologies for studying frontline discretionary workers. He reflects on his own ethnographic and interview-based research among social welfare officers and police culture in the United Kingdom, and comparatively, in places where bureaucracy may be noteworthy more for its absence than its presence.  Like this episode? You might also be interested in Sarah Ball talking about Behavioural Public Policy in Australia Looking for something to read? Mike recommends In Praise of Floods by James C. Scott, and Then We Came to the End by Joshua Ferris.  This interview summary was not synthesised by a machine. Unlike the makers and owners of those machines, the author accepts responsibility for its contents. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sociology

New Books in Public Policy
Michael Rowe, "Researching Street-Level Bureaucracy: Bringing Out the Interpretive Dimensions" (Routledge, 2024)

New Books in Public Policy

Play Episode Listen Later Oct 1, 2025 40:09


Researching Street-level Bureaucracy: Bringing Out the Interpretive Dimensions (Routledge, 2024) is the first among a number of new titles in the Routledge Series on Interpretive Methods that we'll be featuring on New Books in Interpretive Political and Social Science. In it, Mike Rowe discusses the continued relevance of the idea of street level bureaucracy, and the merits of adopting interpretive methodologies for studying frontline discretionary workers. He reflects on his own ethnographic and interview-based research among social welfare officers and police culture in the United Kingdom, and comparatively, in places where bureaucracy may be noteworthy more for its absence than its presence.  Like this episode? You might also be interested in Sarah Ball talking about Behavioural Public Policy in Australia Looking for something to read? Mike recommends In Praise of Floods by James C. Scott, and Then We Came to the End by Joshua Ferris.  This interview summary was not synthesised by a machine. Unlike the makers and owners of those machines, the author accepts responsibility for its contents. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/public-policy

The Bobby Bones Show
TUES PT 2: Dr. Lori Appraises Our Thrift Store Finds + Bobby Is Now Researching Ultrasounds + Tuesday Reviewsday!

The Bobby Bones Show

Play Episode Listen Later Sep 30, 2025 45:25 Transcription Available


Dr. Lori stopped by the studio. She appraised all of our items that we got from thrift stores that we all bought with the intention of finding valuables. She tells us what they are worth vs. what we paid for them. She also tells us crazy stories from her appraisals where things have been worth millions of dollars...we hope that happens to us! Bobby talked about how he has been researching ultrasounds. We talked about Kellie Pickler who once went on a date with an alleged mass murderer. We also all shared our Tuesday Reviewsday of tv shows and movies.See omnystudio.com/listener for privacy information.

Fitt Insider
308. Brian Keller, Co-Founder and CEO of Rorra

Fitt Insider

Play Episode Listen Later Sep 30, 2025 33:13


Today, I'm joined by Brian Keller, co-founder and CEO of Rorra.    Prioritizing design excellence, Rorra sells user-friendly water filters that deliver cleaner, safer drinking and bathing water — backed by NSF testing and transparent performance reports.   In this episode, we discuss building trust in the water filtration category.   We also cover:   Design and UX philosophy Direct-to-consumer vs. retail strategy Educating consumers without scare tactics   Subscribe to the podcast → insider.fitt.co/podcast   Subscribe to our newsletter → insider.fitt.co/subscribe   Follow us on LinkedIn → linkedin.com/company/fittinsider    Rorra's Website: https://rorra.com/  Rorra's Instagram: https://www.instagram.com/rorrawater/  Rorra's X: https://x.com/rorrawater  Rorra's Facebook: https://www.facebook.com/rorrawater    -   The Fitt Insider Podcast is brought to you by EGYM. Visit EGYM.com to learn more about its smart workout solutions for fitness and health facilities.   Fitt Talent: https://talent.fitt.co/  Consulting: https://consulting.fitt.co/  Investments: https://capital.fitt.co/   Chapters:  (00:00) Introduction  (00:25) Brian's background and founding story behind Rorra  (02:30) Researching existing water filtration options and market gaps  (05:15) Product development challenges and manufacturing in stainless steel  (07:15) Building business model and raising capital pre-product  (09:35) Design philosophy and user experience considerations  (11:30) Consumer education and "What's in Your Water" platform  (14:10) Messaging strategy around microplastics and forever chemicals  (16:20) Positioning as health and wellness vs. kitchen appliance  (18:15) Customer segmentation from biohackers to new mothers  (20:15) Partnership strategy with health and wellness influencers  (23:20) Direct-to-consumer vs. retail distribution considerations  (25:40) Filter replacement strategy and subscription model  (28:10) Future product roadmap and staying focused on water  (30:35) Long-term vision as trusted water quality information source  (31:05) Conclusion  

97.5 Y-Country
TUES PT 2: Dr. Lori Appraises Our Thrift Store Finds + Bobby Is Now Researching Ultrasounds + Tuesday Reviewsday!

97.5 Y-Country

Play Episode Listen Later Sep 30, 2025 51:41


Dr. Lori stopped by the studio. She appraised all of our items that we got from thrift stores that we all bought with the intention of finding valuables. She tells us what they are worth vs. what we paid for them. She also tells us crazy stories from her appraisals where things have been worth millions of dollars...we hope that happens to us! Bobby talked about how he has been researching ultrasounds. We talked about Kellie Pickler who once went on a date with an alleged mass murderer. We also all shared our Tuesday Reviewsday of tv shows and movies.See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

The Broadcast Retirement Network
Many #Investors Spend 6 #Minutes or Less #Researching #Stock Buys

The Broadcast Retirement Network

Play Episode Listen Later Sep 29, 2025 14:53


#ThisMorning | Many #Investors Spend 6 #Minutes or Less #Researching #Stock Buys | Toomas Laarits, NYU Stern School of Business | #Tunein: broadcastretirementnetwork.com #Aging, #Finance, #Lifestyle, #Privacy, #Retirement, #Wellness

a16z
From Vibe Coding to Vibe Researching: OpenAI's Mark Chen and Jakub Pachocki

a16z

Play Episode Listen Later Sep 25, 2025 52:05


What comes after vibe coding? Maybe vibe researching.OpenAI's Chief Scientist, Jakub Pachocki, and Chief Research Officer, Mark Chen, join a16z general partners Anjney Midha and Sarah Wang to go deep on GPT-5—how they fused fast replies with long-horizon reasoning, how they measure progress once benchmarks saturate, and why reinforcement learning keeps surprising skeptics.They explore agentic systems (and their stability tradeoffs), coding models that change how software gets made, and the bigger bet: an automated researcher that can generate new ideas with real economic impact. Plus: how they prioritize compute, hire “cave-dweller” talent, protect fundamental research inside a product company, and keep pace without chasing every shiny demo. Timecodes: 0:00  Introduction & Goals of Automated Researcher0:43  The Evolution of Reasoning in AI1:46  Evaluations: From Benchmarks to Real-World Impact5:15  Surprising Capabilities of GPT-56:56  The Research Roadmap: Next 1, 2, 5 Years7:46  Long-Horizon Agency & Model Memory9:44  Reasoning in Open-Ended Domains11:18  The Role and Progress of Reinforcement Learning13:14  Reward Modeling & Best Practices14:21  The New Codex: Real-World Coding16:20  AI vs. Human Coding: The New Default20:07  What Makes a Great Researcher?21:14  Persistence, Conviction, and Problem Selection26:00  Building and Sustaining a Winning Research Culture31:45  Balancing Product and Fundamental Research39:00  The Importance of Compute and Physical Constraints45:50  Maintaining Speed and Learning at Scale47:18  Trust and Collaboration at OpenAI Resources: Find Jakub on X: https://x.com/merettmFind Mark on X: https://x.com/markchen90Find Sarah on X: https://x.com/sarahdingwangFind Anjney on X: https://x.com/AnjneyMidha Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your friends!Find a16z on X: https://x.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zListen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYXListen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated:Find a16z on XFind a16z on LinkedInListen to the a16z Podcast on SpotifyListen to the a16z Podcast on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

8 O'Clock Buzz
Cheshire Cat Comedy: Researching the Silly Side of Science

8 O'Clock Buzz

Play Episode Listen Later Sep 24, 2025 20:07


Sasha Rosser, founder of Cheshire Cat Comedy, talks about the upcoming “Wisconsin Science Festival edition of Words with Nerds“, a juxtapositional event of “scientists hankerin' to be silly”. The event […] The post Cheshire Cat Comedy: Researching the Silly Side of Science appeared first on WORT-FM 89.9.

Up To Date
How do you get rid of forever chemicals? A UMKC professor is researching solutions

Up To Date

Play Episode Listen Later Sep 23, 2025 15:30


Forever chemicals, or PFAS, are found in substances from cosmetics to nonstick pans — and end up in our bloodstreams, unable to break down. UMKC engineering professor Dr. Megan Hart studies how to get rid of these substances, and shares the everyday changes she has made for her health.

Architectette
068: Dr. Angie Scott: Researching Interior Design's Influence on Psychological and Social Well-Being

Architectette

Play Episode Listen Later Sep 22, 2025 40:11


Angie Scott, Ph.D., Allied IIDA, and Allied ASID, is a well-known expert regarding well-being and inclusive design in the built environment. She is the CEO, Principal Design Researcher, and Strategist at Culturwell. Through evidence-based design and strategy, her consultancy aims to improve retention, sense of belonging, and well-being in built environments by collaborating with innovative leaders in architecture, healthcare, housing, and education. Her previous positions include the Community Concept Lead and creator of the WELL Equity Rating at IWBI, and a tenure-track professor of interior design. We talk about: - Angie's multiple advanced degrees and in what ways each has deepened her multidisciplinary understanding of the impacts of interior design.- We next chat about the science of neuroaesthetics and how design can influence stress, emotional regulation, and overall human experience.- We dive into Angie's significant contributions to the creation of the WELL Equity Rating and how it integrates inclusive design strategies to promote health equity.- We end by talking about Angie's design consultancy, how she advises organizations through evidence-based strategies, and her key takeaways from 2025's NeoCon.Connect with Angie: LinkedIn: www.linkedin.com/in/angelita-scott-phd-503a5041Connect with Architectette:- Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.architectette.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Learn more)- Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @architectette⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (See more)- Newsletter:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.architectette.com/newsletter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Behind the Scenes Content)- LinkedIn:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ The Architectette Podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Page and/or⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Caitlin Brady⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Support Architectette:- Leave us a rating and review!Music by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ AlexGrohl⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ from ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Pixabay⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.

Career Zone Podcast
Explore your options

Career Zone Podcast

Play Episode Listen Later Sep 22, 2025 6:50


Exploring your options involves expanding your knowledge of the range of occupations, sectors and organisations that may be of interest to you. In this episode, Dawn Lees, Student Employability and Development Manager, discusses how you can explore the opportunities available to you, whether that's applying for graduate roles or further study. Useful Links: Getting the most from LinkedIn   Networking for career conversations  Exploring options with a degree in…  Researching employers  Careers fair resources  Sector pages  Self-employment: Student Startups | Student Startups | University of Exeter Choosing Postgraduate Study  Lib Guide: About this Research Guide - Researching companies and organisations for your job search​ - LibGuides at University of Exeter

ASCO Daily News
Cancer and Aging: Researching the Path to Longer, More Vibrant Lives

ASCO Daily News

Play Episode Listen Later Sep 18, 2025 18:02


Dr. Monty Pal and Dr. Mina Sedrak discuss the science behind cancer treatment-induced accelerated aging and the development of drug therapies and technologies aimed at helping older patients and cancer survivors. TRANSCRIPT Transcript: Cancer and Aging: Researching the Path to Longer, More Vibrant Lives Dr. Monty Pal: Hello, and welcome to the ASCO Daily News Podcast. I am Dr. Monty Pal. I am a medical oncologist and professor and vice chair of medical oncology here at the City of Hope Comprehensive Cancer Center. I am also host of this podcast. Today, we are going to be talking to somebody that I consider to be my little brother, if you will, in oncology, Mina Sedrak. Mina is an expert in the area of cancer and aging, which really includes the development of drug therapies and technologies that help enable older adults and survivors to live longer, healthier, and more vibrant lives. I am really excited to chat with him. He is an expert not just in cancer and aging but also breast cancer. He was my former colleague here at City of Hope before he moved over to the UCLA Jonsson Comprehensive Cancer Center, where he is an associate professor and director there of the Cancer and Aging Program. Dr. Sedrak's research involves mechanisms behind cancer treatment-induced accelerated aging and really aims to take this science into more of a therapeutic direction, which I am super, super excited about.  Mina, thanks so much for joining us today, and just FYI for our listeners, we have all of our disclosures in the transcript of this episode. Dr. Mina Sedrak: Thank you, Monty. Thank you, Dr. Pal, for having me. I am really excited to be here. Dr. Monty Pal: I feel like we have to go on a first-name basis here with how well we know each other. So Mina, you and I together have witnessed this evolution in cancer and aging. I mean, both of us worked together here with just a legendary figure in the field of geriatric oncology, I will call it, Dr. Arti Hurria, mentor to me, mentor to you, mentor to so many. Can you give us a sense of where cancer and aging has gone since the time that you and I started here together at City of Hope? Dr. Mina Sedrak: Dr. Hurria and her collaborators, Dr. [Willliam] Dale and Dr. [Supriya] Mohile, they were like huge pioneers in the field. They were one of the very first people to highlight the importance of looking at older adults beyond just their chronological age and their comorbidities and moving us beyond just seeing patients and making decisions using what we call the eyeball test. "Oh, this person looks fit or not fit, frail or robust," to really using objective measures to assess our patient's health status and incorporate that assessment into our evaluation of the treatment, prognostication, and discussions with our patients throughout the cancer continuum. And so that is what geriatric oncology has and continues to be, and it is a huge, important part. And their work has laid the foundation to show that when we look at our patients beyond just their chronological age and we look at their functional age, and we do these objective assessments, we can gain much more deeper information to tailor the treatment for our patient that is sitting in front of us, rather than do a prescriptive treatment or over- or undertreatment in that population. So that is sort of where the field is growing, and a lot of the work now is, how do we implement that? How do we put that into clinical practice? Dr. Monty Pal: Well, let me kind of spearhead that discussion, right? I have these moments when I go to the ASCO Annual Meeting – I remember this happened to me a while ago when Dr. Jennifer Temel presented that terrific work around early palliative care interventions, right? Or it even happened to me this year, right, when Dr. Christopher Booth presented the CHALLENGE trial around exercise and colon cancer. You know, these amazing, I am going to say simple, they are not simple, but they are simple interventions relative to, you know, some of the complex drugs and mechanisms that we are using nowadays that really help outcomes for our cancer patients. The big question becomes, how do you implement, right? But my understanding is that there are easy ways for us to take tools in cancer and aging and sort of plug them into our daily practice. Am I right about that? Dr. Mina Sedrak: Yes, and that is something that they are – the Cancer and Aging Research Group, which was founded by Dr. Hurria and now is co-led by Dr. Dale, Dr. Mohile, and Dr. [Heidi] Klepin, they have been incredible at really trying to develop practical tools, like the Practical Geriatric Assessment, which is now endorsed by the ASCO and other NCCN guidelines. And so, there are tools that are becoming more and more practical to help incorporate that into clinic.  Now, what might be practical in a resource-intensive setting may not be practical in some of the limited resources, whether it is rural and/or other countries where the resources may be more limited. So that is why Cristiane Bergerot, Enrique Soto, and others have been really working hard. There was actually a really beautiful paper that was just published in the Journal of Global Oncology, where they have shown that there are guidelines [ASCO Geriatric Assessment Global Guideline] about how to implement these tests, these tools, these assessments in clinical practice, even in different resource settings. So I think we are going to get to the future where this is much more – it is definitely important, but it is much more easily ‘incorporatable' into our practice. Dr. Monty Pal: Yeah, you know how close I am to Cris, and I was so proud when I saw that paper come out. That was really exciting. You know, I skimmed it. I have to tell you, I did not get into the weeds, but it was apparent to me that, you know, some of these geriatric oncology tools are things that, you know, I could probably plug and play into my practice where I am double- and triple-booked over, you know, most slots, right? I mean, I could still probably afford a little bit of time or maybe have, like, a nurse or an extender kind of help participate in the evaluation process. I thought that was, yeah, really, really interesting. Dr. Mina Sedrak: I will just say that at UCLA, we are working with Dr. Arash Naeim, who is a geriatric oncologist, and he has developed an AI platform where the assessments can be done by an AI computer. So it is like talking to your ChatGPT. They can talk to you, and for a few minutes, they will ask you the questions. So you do not even have to fill it out on a piece of paper. You could give the patient a little iPad, put them in a private room while they are waiting for their doctor, and get the results, and it is right there for you. And so, we have been trying to think about how can technology help with the completion of the assessment, at least doing that? And I think it is actually, it has been very cool. We did a pilot study. He is writing that up, and we are going to continue to do some of this exciting work. How do we think about AI in the context of this? And, you know, older adults, they are not like what they used to be. A lot of older adults are very familiar with and comfortable with phones and computers and iPads, much more so today than they were even at the time when Dr. Hurria was alive. Dr. Monty Pal: That is so interesting. You mentioned this, the AI approach is something I have been thinking about in this context because what if, for instance, you know, we have got video monitors all over our hospital, right? What if you are actually just taking a look at that patient as they make their way towards your clinic? Capture that video, use an AI algorithm to say, "Hey, you know, the timed get-up-and-go test in this patient is not particularly good based on what I am seeing here," right? There are so many ways that you could, you know, stir the pot and come up with creative ways to get these tests done. Dr. Mina Sedrak: That's right. And Arash is looking at also sensors. So he has some studies where he is putting sensors inside people's homes, where they would put them, like, on top of an Alexa app or the equivalent. A lot of people have these apps, and basically, they can sense how you are moving around and what you are doing, just movement-wise. And then they can collect that information to gain information about your life beyond just what we are seeing in the 20-minute visit in the clinic. Even when I do a walk test where I get gait speed or physical performance, short physical performance battery, the chair sit-up, those are oftentimes a single, cross-sectional, static measure. But what about the dynamic ability of capturing what has been happening for the last 7 days? What has been happening for the last 25 days between the visits, between the cycles of chemotherapy? And could that inform how I make decisions when I see patients and who do I need to target and identify? And so, we are very excited because really at UCLA, Arash is leading the technology efforts and thinking about implementation of these important measures and these important tools but leveraging new technology. And we do not want to be behind; we want to be ahead of the game. Dr. Monty Pal: I love that idea because there is a Hawthorne effect, isn't there, where you observe a process, and it naturally gets better. I mean, when you ask that patient to get up in the clinic and move, they are probably functioning to the best of their abilities, but we could probably learn a lot from just watching how fast that patient picks up a remote control at home. Some simple movement like that that is volitional would probably help out a ton. And I got to tell you, it is so funny when you mention Arash Naeim's name. I distinctly remember him serving as an attending on the wards when he was brand new at UCLA on faculty when I was a resident there. And his dad is a legendary hematopathologist, right? Dr. Mina Sedrak: I did not know that. Dr. Monty Pal: Yeah, yeah. Faramarz Naeim wrote the book on a lot of heme-path malignancies. Incredible guy. Very, very storied hematopathologist at UCLA.  I could probably go on this topic forever, but in the interest of time, I am going to shift to something that again, I could probably talk about forever, which is this area of senescence that you are involved in. You know, you had mentioned this to me, I am going to say during your outro from City of Hope and towards your transition to UCLA, it is such an exciting area. I mean, understanding the actual biologic process of aging and using those underpinnings to really sort of tailor therapy. So tell us where the state of the science is there with this body of work that you are doing. Dr. Mina Sedrak: As I said before, we have tools now to assess patients and to then do something about the deficits. So if a patient is falling, what we do is we refer them to physical therapy where they can do fall precautions and strength training to give them the information. But all of these supportive care interventions are very important. They are great. But they oftentimes are not targeting the root cause of why they are happening. And so that is really where I have been very interested in, how can we understand why is it that something like chemotherapy or immunotherapy is causing a decline in cognitive function or a decline in physical function? And so that has really led us to think about geriatric oncology rather than a discipline of older adults, but to think about aging as a physiologic process. We are all aging. As every day goes by, we are aging. And what that means is that our bodies are accumulating damage, the cells are being exposed to various stressors, and the repair mechanisms are declining. And as we get older, it is really more damage and less repair mechanism at the cellular molecular level. And it turns out that these processes of how our cells repair and respond to damage are fundamental processes of biological aging. And there has been a large amount of preclinical and now really exciting clinical work to show that there are hallmarks that could be used to assess the rate of which we age by looking at these processes. And that includes things like epigenetics, telomeres, inflammation, and something called ‘cellular senescence.' And we have been interested in my lab in senescence because it is a unique process that has an important role in aging, but it also has a really important role in cancer. Senescence is a cell state. Cells, when they are stressed, they respond to entering this state of senescence. The stress could come from anything. It could come from an oncogene activation. It could come from a reactive oxygen species. It could come from a direct damage to the cell. But it is a cell state, just like apoptosis, necrosis. Senescence is a state in which the cell, in response to that stressor, undergoes an arrest from the G to the S phase. And that arrest is oftentimes associated with a resistance to apoptosis. So then the cell does not die, but it is alive, and it remains metabolically active. And in fact, downstream pathways of these cell cycle inhibition of this G-to-S phase lead to the increase of these transcription factors in the chromatin and lead to the development of these pro-inflammatory factors. So these cells, which can occur in various tissues in the body, can continue to live despite having developed these changes, and then they secrete these proinflammatory molecules like cytokines, chemokines, metalloproteinases, all of these, which are called the senescence-associated secretory phenotype, or SASP. And as we age, we accumulate more and more of these cells, and our bodies are no longer able – our immune system, like macrophages and T cells – are no longer able to remove them effectively. And as we accumulate them in various organs, these organs release a lot of inflammatory cytokines, and the chronic inflammation in that tissue leads to the tissue being damaged, and it does not work as well, and then it starts to decline in function. And that is believed to be how senescence plays a role in aging. It is the accumulation of senescent cells that occurs with increased damage and then the repair mechanism of clearing these cells effectively, which then leads to build up of inflammation and chronic inflammation leads up to damage in multiple tissues. Dr. Monty Pal: This concept to me is fascinating. And I guess the big question is – senescence is bad, right – is it not reasonable to think that this body of research, I mean, if you are able to sort of have a meaningful impact on senescence, it could have implications well beyond oncology. Is that fair? You really could extend lifespan all around. Is that reasonable to think, all-cause mortality? Dr. Mina Sedrak: One hundred percent. And that is what they have been shown in animal models. And the reason senescence is exciting is because it turns out that you can target these cells and you can induce apoptosis of these cells, but it requires active targeting of various pathways, but it can occur. And when it does, and it is done either genetically or pharmacologically in mice, we see that the mice can reverse damage. So if you take an old mouse and you genetically engineer it to remove senescent cells, that mouse will go from being frail to fit. And if you take a young mouse and you induce senescent cells at a high rate and you accumulate them in that mouse, that mouse, even though it is young, will become frail.  So that has really led to this exciting opportunity of, can we translate this finding that we are seeing in animals and in in vivo cells, cell cultures, into humans? And could that have a benefit beyond just one disease? Could it have a benefit in multiple diseases? And not just really longevity, which I think it would be great, but what people are really looking for is, how do we live healthy as we get older? How do we move the curve so that people are not developing chronic diseases in their 60s, but they are developing them in their 80s towards shortening the period of their life with disability rather than what we have currently, which is people are living to 70s, the average life expectancy is in the mid-70s, but they are spending 10 or 11 years in disability of that life. And so, how could we reduce that time frame? Dr. Monty Pal: This is brilliant, Mina. And for our audience, this compelling dialogue that we have had here thankfully is translating to funding for Mina's work. He just scored in the second percentile for his NIH R01 based on this topic. We are so, so proud of you. I mean, it is just remarkable work. It is not easy in the current climate to get funding, and a second percentile score is just absolutely wonderful. You know, Mina, I could probably go on with you for a couple more hours here talking about your work in cancer and aging. I think I am going to have to have you back on the podcast here. But a million thanks for sharing your thoughts here today on the ASCO Daily News Podcast.  And thanks to our listeners too. If you value the insights that you heard today on the ASCO Daily News Podcast, please do not forget to rate, review, and subscribe wherever you get your podcasts. Thanks, Mina. Dr. Mina Sedrak: Thank you so much. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:     Dr. Sumanta (Monty) Pal   @montypal  Dr. Mina Sedrak @minasedrakmd   Follow ASCO on social media:      @ASCO on Twitter     ASCO on Bluesky    ASCO on Facebook      ASCO on LinkedIn      Disclosures:     Dr. Monty Pal:    Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview   Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical   Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis   Dr. Mina Sedrak: Patents, Royalties, Other Intellectual Property: Up-to-Date

Dark Finds Podcast
Gregory A. Freeman - The Forgotten 500 & Lesser Known History

Dark Finds Podcast

Play Episode Listen Later Sep 18, 2025 65:26


Today, I’m thrilled to be joined by bestselling author Gregory A. Freeman, a master of historical true crime and untold wartime stories. We’ll be diving into his incredible book, The Forgotten 500, which tells the gripping story of over 500 allied airmen shot down over Nazi-occupied Yugoslavia during World War II. With the help of local villagers and General  Mihailović’s Chetnik forces, these airmen were hidden from German troops and rescued in one of the largest airlift operations behind enemy lines—a story of courage, ingenuity, and ordinary people doing extraordinary things. Gregory also shares insights into his research, the untold heroism of the people involved, and the dramatic real-life events that make this story both haunting and inspiring. Links Gregory's Website My new thriller How It Falls Apart out now

The Struggle Climbing Show
Weekend Warrior: Shorty Bouldering Skills, Drills, and Mindset

The Struggle Climbing Show

Play Episode Listen Later Sep 17, 2025 68:03


Join The Struggle's Patreon community to get 100+ hours of Bonus Episodes, Pro Clinics, Uncut Videos, and Submit Questions for Future Guests. FREE TRIAL available!  https://www.patreon.com/thestruggleclimbingshow   Weekend Warrior Gentil Nguyen shares insights including: How she sent ten V10s in her first two years outside Challenges (and advantages!) of being 4'11" Why indoor climbs can be harder than outdoors for short climbers Climbing 3 days per week and doing very little other training Why her first season was so magical, and her second season a struggle Dealing with send pressure The importance of releasing expectations Separating self-worth from climbing performance Flexibility and finger strength tips to "climb taller" - BIG THANKS TO THE AMAZING SPONSORS OF THE STRUGGLE WHO LOVE ROCK CLIMBING AS MUCH AS YOU DO: Rúngne: Soft threads and high performing chalk! Use Code STRUGGLE for 10% Off Bags, Buckets, Chalk & Apparel from Rúngne! Petzl: Check out the CONNECT ADJUST at your local gear shop, and learn more at Petzl.com. I love this PAS, it's so easy to use. Rhino Skin Solutions: Perform, Cleanse, Repair… repeat! Amazing skin care products crafted specifically for climbers, whether you're pulling hard indoors or out. Use code STRUGGLE to score a whopping 20% off your purchase!   And check out ALL the show's awesome sponsors and exclusive deals at thestruggleclimbingshow.com/deals - Here are some AI generated show notes (hopefully the robots got it right) 02:11 Gentil's Climbing Background and Achievements 02:48 Host's Recent Outdoor Climbing Experience 19:40 Gentil's Climbing Philosophy and Training Routine 27:26 Gentil's Transition to Outdoor Climbing 33:43 Planning Bouldering Trips 34:48 Setting Expectations and Priorities 36:28 Researching and Identifying Boulders 37:18 Inspiration and Community Impact 37:54 Safety Gear Spotlight: Petzl Connect Adjust 39:41 Challenges of Short Climbers 41:58 Mental Journey and Training Blocks 46:43 Balancing Performance and Enjoyment 54:07 Future Goals and Outdoor Climbing 55:52 Indoor Climbing and Personal Growth 56:40 Tips for Short Climbers 01:00:10 Red Rock Bouldering Recommendations 01:04:15 Conclusion and Final Thoughts - Shoutout to Matt Waltereese for being a Victory Whip supporter on Patreon! So mega. - Follow along on Instagram and YouTube: @thestruggleclimbingshow  - This show is produced and hosted by Ryan Devlin, and edited by Glen Walker. The Struggle is carbon-neutral in partnership with The Honnold Foundation and is a proud member of the Plug Tone Audio Collective, a diverse group of the best, most impactful podcasts in the outdoor industry.   And now here are some buzzwords to help the almighty algorithm get this show in front of people who love to climb: rock climbing, rock climber, climbing, climber, bouldering, sport climbing, gym climbing, how to rock climb, donuts are amazing. Okay, whew, that's done. But hey, if you're a human that's actually reading this, and if you love this show (and love to climb) would you think about sharing this episode with a climber friend of yours? And shout it out on your socials? I'll send you a sticker for doing it. Just shoot me a message on IG – thanks so much! 

Historical Drama with The Boston Sisters
Designing a Fashion Narrative for DOWNTON ABBEY: THE GRAND FINALE (Ep. 75)

Historical Drama with The Boston Sisters

Play Episode Listen Later Sep 16, 2025 46:56


The 5th season premiere! In Episode 75 we go behind-the-scenes with DOWNTON ABBEY costume designer Anna [Mary Scott] Robbins who reflects on her journey designing costumes for two DOWNTON ABBEY series and the three feature films including the recent and final chapter DOWNTON ABBEY: THE GRAND FINALE.In this conversation, Anna highlights the importance of creating costumes that reflect the characters' shifting roles and status over a decade at Downton Abbey, both upstairs and downstairs. ------TIMESTAMPS0:53 - DOWNTON ABBEY: THE GRAND FINALE synopsis1:27 - Anna Robbins introduction3:06 - Anna Robbin's costume designer' journey8:59 - Downton Abbey art deco style and women's changing role through fashion12:52 - 1920s fashion influences on contemporary designers13:55 - Researching fashion for costume designs17:57 - Collaborative process of the DOWNTON ABBEY production and design teams21:45 - Designing a stand-out tomato red gown for Lady Mary23:09 - Generic Break23:44 - Hats, gloves, and jewelry -- character  is in the details29:13 - Edith and Mary as career women: London style and country estate style32:27 - Designing to reflect upstairs/downstairs hierarchies and generations39:07 - Costuming characters' story arcs (optional addition Daisy's evolution)41:20 - Anna's desired adaptations Chanel biopic, and book adaptation pick - Sarah Winman's Still Life novelTranscripts are available to download from the webpage for this podcast episode. Visit michonbostongroup.com/bostonsistersSUBSCRIBE to HISTORICAL DRAMA WITH THE BOSTON SISTERS® on your favorite podcast platformENJOY past podcasts and bonus episodesSIGN UP for our mailing listSUPPORT this podcast  SHOP THE PODCAST on our affiliate bookstoreBuy us a Coffee! You can support by buying a coffee ☕ here — buymeacoffee.com/historicaldramasistersThank you for listening!

Project Upland Podcast
#332 | Hunting and Researching Upland Birds on Working Western Landscapes with Dave Dahlgren

Project Upland Podcast

Play Episode Listen Later Sep 12, 2025 113:50


In this episode of The Birdshot Podcast, host Nick Larson discusses the world of grouse research, wildlife conservation, and the use of pointing dogs in citizen science. We explore how upland bird hunters and scientists can work together to collect data, and how David has been at the forefront of using dogs and technology to study sage grouse and other upland birds David Dahlgren is an Associate Professor and Rangeland Wildlife Extension Specialist at the University of Utah. His research focuses on upland game bird species, particularly sage grouse and dusky grouse, as well as wildlife management on rangelands. With over 20 years of experience in the field, David combines his passion for upland bird hunting with cutting-edge research, including the use of pointing dogs in citizen science projects. He's also the creator of the Western Range Ranch Management Academy, which teaches ranchers how to balance wildlife conservation with livestock management. Expect to Learn How pointing dogs contribute to wildlife research and citizen science projects. The importance of sagebrush cover for the persistence of sage grouse populations. Insights into livestock grazing and its surprising benefits for wildlife conservation. The value of dog work in tracking and understanding grouse behavior. The integration of technology in Wildlife Studies. David's personal favorite bird species to hunt and his experiences with Mearns quail, chukars, and more. Episode Breakdown with Timestamps [00:00:00] - Introduction  [00:04:54] - Different Kinds of Dogs [00:17:40] - David's Background and how it relates to Upland Birds [00:34:40] - What is meant by Sagebrush Steppe [00:49:30] - The Biggest Threats for Sagebrush [00:58:29] - Understanding sage grouse habitat [01:04:43] - Benefits of using Dogs in Science [01:28:08] - Learning from 20 Years of Studying Grazing [01:43:20] - David's Favorite Shotgun [01:45:51] - Conclusion Follow the Guest David: Instagram: https://www.instagram.com/dkdbio/   LinkedIn: https://www.linkedin.com/in/david-dahlgren-0b9004b7/  Rangeland Wildlife Ecology and Conservation open access link https://link.springer.com/book/10.1007/978-3-031-34037-6 Western Ranch Management Academy website https://link.springer.com/book/10.1007/978-3-031-34037-6 Faculty webpage https://qanr.usu.edu/directory/dahlgren-david Follow Host Nick: Instagram: @birdshot.podcast Website: www.birdshotpodcast.com Listening Links: Spotify: https://open.spotify.com/show/17EVUDJPwR2iJggzhLYil7 Apple Podcasts: https://podcasts.apple.com/us/podcast/birdshot-podcast/id1288308609 YouTube: http://www.youtube.com/@birdshot.podcast SUPPORT | http://www.patreon.com/birdshotUse Promo Code | BSP20 to save 20% on https://www.onxmaps.com/hunt/app Use Promo Code | BS10 to save 10% on https://trulockchokes.com/ The Birdshot Podcast is Presented By: https://www.onxmaps.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Plant Based Briefing
1145: I Spent Months Researching Alternatives to Bird Feathers. Spoiler: It's Possible by Emma Håkansson at GoodOnYou.eco 

Plant Based Briefing

Play Episode Listen Later Sep 12, 2025 7:54


I Spent Months Researching Alternatives to Bird Feathers. Spoiler: It's Possible “What if, instead of plucking ostriches to use their feathers in fashion, designers sought to celebrate the qualities of plummage with alternative materials that don't exploit animals? That's what Emma Håkansson, founding director of Collective Fashion Justice, has spent months working with designers to do, trialling new ways to create the texture. Here, Håkansson discusses why this is a pressing animal welfare issue, and the new techniques and materials designers should know.” Listen to today's success story written by Emma Håkansson at GoodOnYou.eco #vegan #plantbased #plantbasedbriefing #ethicalfashion #collectivefashionjustice #ostrichfeathers  ========================== Original post:  https://goodonyou.eco/more-ethical-bird-feather-alternatives/  ========================== Related Episodes: 573: [Part 1] The Human Rights Issues Behind Fashion's Animal Supply Chains https://sites.libsyn.com/342677/573-part-1-the-human-rights-issues-behind-fashions-animal-supply-chains-by-emma-hkansson-at-goodonyoueco 574: [Part 2] The Human Rights Issues Behind Fashion's Animal Supply Chains https://sites.libsyn.com/342677/574-part-2-the-human-rights-issues-behind-fashions-animal-supply-chains-by-emma-hkansson-at-goodonyoueco  518: Fashion and Animal Welfare: Everything You Should Know Before You Buy https://sites.libsyn.com/342677/518-fashion-and-animal-welfare-everything-you-should-know-before-you-buy-by-lara-robertson-at-goodonyoueco  472: The Environmental Impact of Animal Products in Fashion https://sites.libsyn.com/342677/472-the-environmental-impact-of-animal-products-in-fashion-by-joanna-psaros-at-goodonyoueco  315: Is Down Feather Ethical and Sustainable? https://sites.libsyn.com/342677/315-is-down-feather-ethical-and-sustainable-by-emma-hakansson-at-goodonyoueco  Use search feature at https://www.plantbasedbriefing.com/episodes-search   ========================= Good on You is the world's leading source for fashion brand ratings. They're a group of campaigners, fashion professionals, scientists, writers and developers who care for our planet, people and animals and help drive the whole industry to become more sustainable and fair.  They help us understand we can all play a part in driving fashion to be more sustainable and ethical - by choosing to wear clothes from ethical labels; and by re-wearing, recycling, swapping and thrifting.  =========================  FOLLOW THE SHOW ON: YouTube: https://www.youtube.com/@plantbasedbriefing     Spotify: https://open.spotify.com/show/2GONW0q2EDJMzqhuwuxdCF?si=2a20c247461d4ad7 Apple Podcasts: https://podcasts.apple.com/us/podcast/plant-based-briefing/id1562925866 Your podcast app of choice: https://pod.link/1562925866  Facebook: https://www.facebook.com/PlantBasedBriefing     LinkedIn: https://www.linkedin.com/company/plant-based-briefing/   Instagram: https://www.instagram.com/plantbasedbriefing/      

Literacy Untangled Podcast
#61 - When One Parent Says 'Just Give It Time' and the Other Is Researching Dyslexia at Midnight

Literacy Untangled Podcast

Play Episode Listen Later Sep 12, 2025 6:28


Ever found yourself down a late-night research rabbit hole about dyslexia while your partner is sound asleep, completely unbothered? Do you feel like you're fighting this battle alone, trying to advocate for your child's reading struggles while your partner says, "Just give it time"? If this sounds familiar, you're not alone, and this episode is for you. I want to show you why this divide happens and, more importantly, give you a path forward. So, instead of arguing, discover how to shift the conversation and get on the same page. Remember, this isn't about winning an argument; it's about getting both parents on the same team, fighting for your child's future, not with each other. Tune in and let's get you a united front. Would you like to understand reports, ask the right questions, and get schools to take you seriously? Together Through Dyslexia 6-month program provides expert mentorship for parents of dyslexics and struggling readers, and you can claim your spot now at https://www.literacyuntangled.com/together-through-dyslexia! My mini-course, From Lost to Empowered: How to Get Your Struggling Reader: The 3-Step Evaluation Request Blueprint for Parents of Struggling Readers, is available now! This 3-step evaluation request blueprint walks you through everything you need to know, from documenting concerns with the right details to writing the evaluation request letter with language that triggers legal timelines, to handling what to do when schools try to push you off, and so much more. You can break through the barriers NOW and get instant access at https://www.literacyuntangled.com/from-lost-to-empowered. Topics Covered: The ways in which reading instruction has changed over the past 20 to 30 years, and why this means that old methods just don't work anymore [1:53] How your child is developing a story about themselves based on their struggles and the feelings this can lead to [2:08] The Matthew Effect explained: why children who fall behind in reading tend to fall even further behind over time [2:30] Specific questions to ask your child about how they perceive reading to shift the conversation from a problem to a deeper understanding of their unique brain [3:22] Why allowing children to articulate their experience in their own words can be such a powerful tool [4:18] A look at the framework for approaching a resistant partner using a strategic approach that moves from emotion to curiosity, and from confrontation to collaboration [4:34] Key Takeaways Waiting until the end of third grade to address reading difficulties can be highly detrimental. Shifting the conversation from arguing about a "problem" to being curious about your child's experience can be a game-changer. A reminder that the goal isn't to win an argument, but to create a united front. When you're ready to work with me, here are 3 ways I can help you: Join the waitlist to find out when my long-awaited course, Untangling Dyslexia: From Identification to IEP, opens up again! Subscribe to my Podcast Literacy Untangled Podcast for bimonthly episodes on navigating the dyslexia journey with your kid. Want 1:1 help from an Orton-Gillingham expert? Book a call to see how I help kids who are struggling to learn how to read. Have a question or want a certain topic covered? Send an email to jennie@literacyuntangled.com or a DM on Instagram. I want to support parents with dyslexic children and get this content in the hands of those who need it most. Click the share button and send away! Thank you. Listen to the episode on Apple Podcasts, Spotify or on your favorite podcast platform.

Artspeak Radio
Artspeak Radio with Owens, Brick, Skedel, Griffin, and Marten

Artspeak Radio

Play Episode Listen Later Sep 12, 2025 60:03


Artspeak Radio, Wednesday, September 17, 2025, 9am -10am CST, 90.1fm KKFI Kansas City Community Radio, streaming live audio www.kkfi.org Producer/host Maria Vasquez Boyd welcomes artists Pierre Owens, DeAnna Skedel, KE Griffin, Anna Marten, and filmmaker Jon Brick. JON BRICK- Experience the magic of Ronzo at an exclusive screening of Jon Brick's new feature documentary—a lively tribute to the man who turned a small Southern town into a creative mecca. Ronzo is a witty, heartfelt documentary about Ron Shapiro — affectionately known as Ronzo — who turned Oxford, Mississippi, from a conservative college town into an unlikely cultural mecca. His Hoka Theater became the beating heart of the town's creative underground — a sanctuary for misfits where college students mingled with literary giants like Willie Morris, John Grisham, and Barry Hannah. The Hoka hosted music, indie films, plays, and midnight adult film screenings, and drew counterculture icons like Abbie Hoffman, Allen Ginsberg and Hunter S. Thompson. It also helped launch the careers of artists and musicians, including members of Wilco, North Mississippi Allstars, and Widespread Panic. Outside the theater, Ronzo stirred up local politics, using wit and empathy to provoke dialogue and bridge divides. His legacy continues through Hoka Days, an annual celebration in his honor, culminating in a lively parade in Oxford. Though Ronzo's death left a void, his influence remains, reminding us of the power of creativity, inclusion, and the arts in shaping communities. Ronzo's story is told through the voices of his closest friends and family, including musicians from Wilco, Widespread Panic, and the North Mississippi Allstars; actress Joey Lauren Adams (Chasing Amy); renowned Southern writers; and TV and radio hosts Jim Dees, John T. Edge, Robert Gordon and Tom Franklin — to name a few. The screening is Saturday, September 27th, 7:30pm Grand Avenue Temple 206 E 9th Street KCMO, 64106 Tickets ($15) are available to purchase through the International Documentary Association, the film's fiscal sponsor with this link: https://ronzo.allyrafundraising.com/events/922 If you are unable to attend, we are accepting donations also through the International Documentary Association Fiscal Sponsorship Program: https://ronzo.allyrafundraising.com/ PIERRE OWENS- I'm an artist with Autism who started drawing when I was a young kid. I graduated from Paseo Academy in 2007 as a Creative Writing Major. I found my true calling back in 2009 while I did some job shadowing at AbilityKC. I was diagnosed with Autism at the age of two. Years later, he found my true love for movies. Movies have been a true part of my art. I come up with great movie ideas and create great movie posters for them. I'm an outsider artist with no art school education but has a God-given talent to create such beautiful portraits. The things that inspire me to draw are the people that I met, the places I've visited and the movies that I watched. I've done commissioned drawings for people across the country and some from around the world. My drawing style is very traditional and cartoonist-like. I mostly draw from pictures that I look at and from memory as well. Three years after I found my calling in the art world, I met professional artist Wes Benson and he inspired me to go further in my art career. In 2013, I started having my very first art show at his studio at The Bauer. In 2015, I showcased some of my drawings with Charles Mooneyham at an exhibit in St. Louis. In 2016, I presented a special drawing to former KC Mayor Sly James. In 2017, I had my first exhibit at the Bruce R. Watkins Center and it was a success. Months later, I was featured in an interview with former teacher Christopher Ulmer on his page called Special Books by Special Kids when I was showing off my ability to recall any movie release date. Right after that, drawing commissions started pouring in. They couldn't get enough of my work. In 2022, I had a second pop-up art fair at the Bruce R. Watkins Center. In 2024, I was featured in an exhibit with Harold Smith and other local artists at the Leedy-Voulkos Art Center. A few months after that, I had a couple of art fairs with fellow artist Trey Loomis at the City Market. In September of 2024, I participated in the 18th & Vine Arts Festival with Harold Smith, Trey Loomis and Crystal Major. Back in April of 2025, I participated in ArtsFusion KC and sold some art there as well. I'm currently participating in an exhibit called Digitalfiles/Flattiles at the Emily and Todd Voth Artspace. I have to say that being an artist can be tough sometimes but creating something beautiful can be the easy part. There were times I wanted to give up on my art but courage and the blessings from God has allowed me to never give up and to keep going. I had many ups and downs in my creative journey but I always come back up on top. Art will always be my true love.You can contact me for custom made drawings or previously drawn artwork by emailing at owenspierre81@yahoo.com or by calling or texting me at (816) 885-3772. ANNA MARTEN- In 2024, after nine years as a production illustrator who hand-painted signs and murals for a grocery store, I stepped away from my position and began to reimagine my creative process without the barriers of a corporate art world. I'm now getting reacquainted with the parts of myself that create for creation's sake. As an avid daydreamer, I acknowledge that memory plays tricks on us. If there's a boundary connecting memory, reality, and fantasy, then my art probably exists between all three. Lesser observed spaces draw my attention because I'm interested in the implied environment rather than the literal one. Whether there's a narrative to be uncovered or imagined, I enjoy recentering overlooked and candid moments as fantastical realities. Illustrating words was my primary livelihood for so many years, but I'm now more interested in exploring the conversation that exists between mediums. How do I conjure a story with both photography and painting? Can the two styles of communication work together while maintaining separate identities? In working together, is the result decipherable or purely fantastical? As an interdisciplinary creator, I'm open to learn or experiment with whichever mediums work best for each project. Anna Marten is a Kansas City-based multimedia illustrator with a BFA from the Kansas City Art Institute. She approaches traditional processes such as hand-lettering and painting with vibrancy. Her professional practice has incorporated hand-painted signs, murals, and displays into Kansas City businesses for over a decade. As an interdisciplinary artist, she has utilized screen printing, photography, acrylic paint, found objects, and sculpture for exhibition pieces. A few exhibit collaborators include the KC Fringe Festival, MCC, InterUrban Arthouse, and Vulpes Bastille. DEANNA SKEDEL has been an artist and professor in Kansas City since 2002. Her eclectic, wide-ranging studio practice has been akin to the practice of reading tea leaves: an act of both divination and meditation. DeAnna first began showing at the Ohio Craft Museum while still in undergrad. Graduate school at the School of the Art Institute of Chicago brought about some time working in theater. Sculpture and good friends presented opportunities at such venues as the US/UKContemporary Cast Iron SculptureProject and Overflow/Fluids (LA Art Girls) at the Getty Museum Los Angeles, California. She has been a Kansas City Avenue of Arts recipient, part of the Urban Culture Project, included in the book The Sixth Surface: Steven Holl Lights the Nelson-Atkins Museum and a member of the Kansas City chapter of the social justice organization, Avodah. Skedel has been honored by her peers at Metropolitan Community College-Blue River with the Missouri Governor's Award for Excellence in Teaching, and is honored by students who call her “some crazy combination of Mr. Miyagi and Bob Ross” and is happy her children do not find her too embarrassing. Skedel has been an artist and professor in Kansas City since 2002. Her diverse, expansive studio practice resembles ... cooking—a meditative process of infusion and maceration. Reflecting on her life, she says, "As an artist, academic, and a parent of neurodiverse teenagers, I navigate evolving social concerns, teaching and learning styles, all while experiencing a shifting identity. At times, it feels like I am experiencing a 'puberty of maturity,' where, despite societal invisibility and the many layers my roles add, my personal evolution is accelerating." KAREN E (KE) GRIFFIN -I am a creative, proactive and transformative textile and performing artist possessing the innovative ability to formulate fabrics and seams into wonderful stories. My visionary process evokes and informs viewers by exploring tangible and verbal artforms. The art quilts, abstracts and panels are constructed of music notes, adinkra symbols, feathers, beads, prints, patterns, denim and 2D. The textiles contain the following materials: paper, African or cotton fabric on canvas or wood panels. After four or more art pieces are completed, stories are implemented to embrace the art quilt or abstracts. For 21 days, I shut off my outer body to support me with framing a piece(s). After the layout(s) is unveiled, I hand-select prints, patterns and threads to depict breathtaking textiles. My concepts consist of complying black outline drawings, digital graphing, photography, crayon drawings on poster board and sewing. Machine sewing or hand-stitching fabric on paper, canvas or cotton is my form of meditating. When my mind is relaxed, my hands control the progress and final art piece. I enjoy joining seams with fabric to generate a story, depicting my ancestors' journey to and in America. It takes two or more months to produce an array of textiles and stories from an idea to wall hanging, art show or presentation. Researching and studying the journey of African-Americans play an important role in designing, displaying and promoting my textiles. The primary purpose of sewing seams and applying a story is design to engage, empower and educate viewers of my creations about the history of African-Americans. As a textile and performing artist, I am honored to teach and share the journey of enslaved Africans in America through art and storytelling. My first solo exhibition consisted of twenty-one textiles on clotheslines with rope, clothespins, fencing post, burlap, buckets and concrete. The exhibit was designed to inform all generations with exploring the journey of enslaves, seeking FREEDOM in America. This quote best expresses how I hope people feel when they view my work. “There are times people don't want to hear what you're saying, but they will relate and engage to what you express through ART”. Art by .E Lewis

Italian Roots and Genealogy
Uncovering Italian American Heritage

Italian Roots and Genealogy

Play Episode Listen Later Sep 11, 2025 35:31


Send us a textIn this engaging conversation, Bob Sorrentino interviews Stephanie Detton, the creator and host of the podcast 'Italian American Stories.' They delve into Stephanie's family heritage, her journey into genealogy, and the inspiration behind her podcast. The discussion highlights the importance of storytelling in preserving cultural history, the challenges of researching family backgrounds, and the fascinating tales that emerge from Italian American archives. Stephanie shares unique stories, including the intriguing lives of her ancestors and the weird and wonderful tales she has uncovered in her research.Genealogy drives a passion for storytelling.Everyday Americans have fascinating stories worth sharing.Researching family history can uncover unexpected tales.Italian Americans have a rich cultural history in the U.S.Podcasts can be a powerful medium for storytelling.Unique stories often come from local archives and newspapers.The importance of community support in creative endeavors.Researching names can lead to surprising discoveries.Cultural heritage is a vital part of identity.The podcasting journey can evolve from personal interests.Turnkey. The only thing you'll lift are your spirits.Italian Marketplace LLCOnline tee shirts, hoodies and more for ItaliansDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showPurchase my book "Farmers and Nobles" here or at Amazon.

Your Podcast Consultant
Stop Researching and Start Recording!

Your Podcast Consultant

Play Episode Listen Later Sep 6, 2025 6:46 Transcription Available


First up, let's talk about the wild ride of launching a podcast. It's like trying to throw a birthday party and making sure every single balloon is inflated to perfection. Spoiler alert: it's impossible. Our main speaker, Dave, dives headfirst into the chaotic world of podcasting, where he points out that there's never a perfect time to hit that record button. Seriously, if you're waiting for the planets to align or for your cat to give you the nod of approval, you might be waiting forever. Instead of obsessing over SEO and storytelling like it's a PhD thesis, just grab that mic and start chatting! Trust me, your first episode will probably make you cringe later on, but that's part of the journey. And hey, if you're gonna mess up, might as well do it while having fun, right?Takeaways: Launching a podcast is like having a baby: there's never a perfect time, so just go for it! Researching SEO and storytelling can easily turn into procrastination, so stop buffering and hit record! Your podcast is a recipe, not a statue—it's all about experimenting and adjusting as you go! If you're waiting for perfection, you might just be overthinking everything—start recording already! Listening to your own content is hard, but if you can't handle it, maybe it's not ready for the world. Remember, aiming for perfection might just land you somewhere really good instead, so embrace the journey! Start Your Podcast!Are you looking to start your own podcast but don't know where to begin? Look no further than the School of Podcasting. Our comprehensive online courses and one-on-one coaching will teach you everything you need to know, from equipment and editing, to marketing and monetization. With our proven methods and expert instructors, you'll be creating high-quality, engaging content in no time. Say goodbye to the frustration and uncertainty, and hello to a successful podcasting career with the School of PodcastingMentioned in this episode:Your Voice is Your LegacyYou have lived things that need to be heard. You can help other people, and I'm here to help. Don't let your story die within you, release your legacy today and start your podcast. I've helped hundreds (thousands?) of podcasters and I can help you. It's time to do it.School of PodcastingThis podcast uses the following third-party services for analysis: OP3 - https://op3.dev/privacy

The Exchange
Ristretto | Why is it Called a Quaker? Ep. 10

The Exchange

Play Episode Listen Later Sep 3, 2025 5:43


The term 'Quaker' in coffee refers to under-roasted beans.Quaker Brown is linked to the clothing of the Society of Friends.Quaker defects are a result of immature green beans.Quaker defects are the same color as clothing worn by many in the Society of Friends in the 1800'sThe term 'Quaker' was initially derogatory but was reclaimed.Researching coffee history can reveal surprising connections.  Part of The Exchange Coffee Podcasting Network TAKE OUR LISTENER SURVEY Visit and Explore Covoya!

Experts in Sport
E96: Strength in Numbers - Researching Gender Equity in Wheelchair Rugby

Experts in Sport

Play Episode Listen Later Sep 3, 2025 44:10


What does gender equity really mean in a sport as physically demanding and strategically complex as wheelchair rugby? In this episode, we dive into a groundbreaking research project that's challenging assumptions and driving change for women in para-sport. Through personal reflections and expert insights, we explore why representation matters, how performance is measured, and what it takes to build inclusive pathways for female athletes.Joining the conversation are Dr Thomas Rietveld from the Peter Harrison Centre for Disability Sport at Loughborough University, Richard Allcroft, President of World Wheelchair Rugby, Lauren Templeton, Regional General Manager for Europe at World Wheelchair Rugby, and Jason Brisbane, Chief Executive Officer of Great Britain Wheelchair Rugby. Together, they share personal insights, strategic goals, and reflections on the Women's Cup in Paris — a key testing ground for inclusive rule changes like the 0.5-point classification for female athletes. Whether you're a coach, policymaker, athlete, or simply curious about the future of inclusive sport, this episode offers a compelling look at how data, collaboration, and lived experience are shaping the next phase of wheelchair rugby.Intros: 0:00Gender Equity: 4:19 The research: 11:11 The rule change: 15:56 The athlete voice: 21:44 Collaboration: 28:42 Research call to action: 34:33 Takeaways: 36:46#loughborough #university #education #student #Experts in sport #podcast #sport #research #experts in health #fitness #women #women's health #women in sport #women's hub #world cup #rugby #women's rugby #wheelchair #wheelchair rugby #gender #equity

So You Want To Be A Writer with Valerie Khoo and Allison Tait: Australian Writers' Centre podcast
Writing Podcast Episode 679: Laila Lalami discusses her latest novel, 'The Dream Hotel'

So You Want To Be A Writer with Valerie Khoo and Allison Tait: Australian Writers' Centre podcast

Play Episode Listen Later Sep 1, 2025 44:43


What if you could be locked away simply for having disturbing dreams? That’s part of the premise in internationally acclaimed author Laila Lalami’s latest novel, The Dream Hotel. In this episode, Laila discusses the themes that inspired and eventually mirrored her book, along with her background in writing, her daily routine, writing tips and more. 00:00 Welcome04:50 Writing tip: Avoid clichés!07:58 WIN!: A Forbidden Alchemy by Stacey McEwan09:35 Word of the week: ‘Apophenia’10:03 Writer in residence: Laila Lalami11:02 Laila outlines The Dream Hotel12:17 Speculative Fiction and real-world parallels14:20 The language of this near future world19:40 Dreams and their cultural significance21:58 Speculative Fiction and dreams as data22:50 Researching the novel27:17 The role of algorithms in society30:11 Laila’s journey to becoming a writer34:33 Balancing teaching and writing37:27 The challenges of book promotion39:20 Future writing projects40:59 Laila’s writing tips42:43 Final thoughts Read the show notes Connect with Valerie and listeners in the podcast community on Facebook Visit WritersCentre.com.au | ValerieKhoo.comSee omnystudio.com/listener for privacy information.

English Learning for Curious Minds | Learn English with Podcasts

✨ Back To School Sale - Save 25% - https://bit.ly/BackToSchoolSept25Ends 23:59, Sunday 7th September.--Ever wondered how the (podcast) sausage is made?  In this slightly "meta" episode, I reveal the step-by-step process to make an episode of English Learning for Curious Minds.  Choosing podcast topics: interest, timelessness, and neutrality Avoiding controversial topics and current affairs Researching topics through books, articles, and data Writing full scripts for natural conversation flow Using a variety of vocabulary for diverse learners Rewriting scripts after initial recordings Aiming for 20-minute episodes, 2,500-3,000-word scripts Incorporating AI tools for brainstorming and editing Results from our 2025 listener survey Thank you! Full interactive transcript, subtitles and key vocabulary available on the website: https://www.leonardoenglish.com/podcasts/how-i-make-podcast-episodes ---You might like:⚡️ Back To School Sale - Save 25% [ends 23:59, Sunday, 7th September]

Evidence Based Birth®
EBB 369 - What is Mistreatment in Childbirth? with Dr. Morgan Richardson Cayama from Team EBB

Evidence Based Birth®

Play Episode Listen Later Aug 27, 2025 43:59


Dr. Morgan Richardson Cayama, public health researcher, doula, and member of Team EBB, joins Dr. Rebecca Dekker to explore the critical issue of mistreatment in maternity care. Drawing from her doctoral research—including interviews with Black women in Florida and data from the Giving Voice to Mothers study—Dr. Morgan shares what respectful maternity care really looks like, and how the lack of it can negatively impact birth outcomes and future healthcare decisions. She also opens up about her own preterm hospital birth, offering insight into how even the most informed parents can feel disempowered by coercive hospital systems. Together, they break down the systemic roots of obstetric violence and offer community-driven recommendations for change.   Content Note: Discussion of obstetric mistreatment, medical trauma, discrimination in maternity care, and stillbirth.   (04:35) How a Global Health Class Sparked a Career in Public Health (08:17) From Dissertation to Delivery: Dr. Morgan's Birth Story (15:57) Reflecting on the Power of Language and Provider Ultimatums (19:40) What Mistreatment in Maternity Care Looks Like in the U.S. (24:08) Florida's Unique Birth Landscape (26:10) Researching the Lived Experiences of Black Birthing Women (28:13) What Respectful Care Really Means to Patients (35:29) Participant Recommendations for Healthcare Providers and Parents (40:01) How a Single Birth Interaction Can Shape Lifelong Views on Healthcare (42:00) Centering the Voices of Birthing People to Create Change   Resources Access the FREE 2-page handout: ebbirth.com/rmc Read the Giving Voice to Mothers study: birthplacelab.org Listen to EBB 338 – Respectful Maternity Care with Dr. Jessica Brumley   For more information about Evidence Based Birth® and a crash course on evidence based care, visit www.ebbirth.com. Follow us on Instagram and YouTube! Ready to learn more? Grab an EBB Podcast Listening Guide or read Dr. Dekker's book, "Babies Are Not Pizzas: They're Born, Not Delivered!" If you want to get involved at EBB, join our Professional membership (scholarship options available) and get on the wait list for our EBB Instructor program. Find an EBB Instructor here, and click here to learn more about the EBB Childbirth Class.

My Simplified Life
If You're Reading This, It's Meant For You with Leigh Stein

My Simplified Life

Play Episode Listen Later Aug 26, 2025 33:34


In this episode of Read the Damn Book, host Michelle Glogovac sits down with author Leigh Stein to discuss her new novel, If You're Seeing This, It's Meant for You. Their conversation explores how TikTok culture, tarot, and generational shifts shape the story, while also unpacking themes of therapy, identity, and digital life. Leigh shares the personal experiences and research that informed her writing, offering a candid look at both her creative process and her perspective on content creation in today's world. The episode closes with Leigh reflecting on her evolution as a writer and where readers can discover more of her work.What We're Talking About...Leigh's new novel blends gothic mystery with modern TikTok culture.The concept of hype houses is a real phenomenon among influencers.Researching tarot card reading added depth to the novel's themes.Therapy is a recurring theme, reflecting its growing acceptance in society.TikTok's algorithm is unique, focusing on personalized content recommendations.The character of Owen Wilson the rabbit symbolizes innocence and connection.Generational differences are explored through the characters' interactions.The book features a love triangle that challenges age norms.Leigh's personal experiences influence her writing and character development.The novel encourages readers to reflect on their own life choices.Chapters00:00 Introduction and Celebration of New Book04:33 Exploring the Themes of Self-Care and TikTok Culture07:26 The Role of Therapy in Modern Life10:38 Navigating Content Creation and TikTok Dynamics13:30 The Fascination with Tarot and Its Influence16:27 The Unique World of Influencers19:25 Character Development and Personal Connections22:41 Generational Perspectives and Relevance25:28 Romantic Dynamics in the Novel28:39 Reflections on Life Choices and Paths31:27 Conclusion and Where to Find the Book32:49 Introduction to the Book and Its Themes33:19 Exploring Tarot and TikTok CultureLinks MentionedIf You're Seeing This, It's Meant For You by Leigh Steinhttps://bookshop.org/a/99223/9780593983645 Leigh Stein's Websitehttps://www.leighstein.com/

Branding Room Only with Paula T. Edgar
How to Prepare for a Conference to Maximize Your Personal Brand Impact

Branding Room Only with Paula T. Edgar

Play Episode Listen Later Aug 26, 2025 31:05


Conferences offer incredible opportunities to network, learn, and strengthen your personal brand—but only if you're prepared to make the most of them. With the right approach, you can expand your mindset, build valuable connections, and uncover new insights. To help you get there, I've put together a step-by-step guide using one of my favorite tools: an acronym!In this episode of the Branding Room Only podcast, you'll discover how to maximize your personal brand impact at conferences. We'll cover crafting an effective elevator pitch, setting clear goals, networking with purpose, and following up to create lasting connections that truly matter.2:00 - Crafting your elevator pitch: what to include, the value of adding fun facts, and the importance of how you sound as you introduce yourself8:21 - Organizing your goals for conferences: suggestions, recommendations, and the benefit of flexibility10:56 - Networking with intent: how to prepare beforehand and the importance of quality over quantity13:13 - Following up effectively: how to make connections, use streamlining tools, and approach your follow-up messages16:50 - Engaging before and after the conference: how to use social media and prepare for and continue conversations online19:07 - Researching the event: how to use the past to maximize your opportunities20:32 - Elevating your online presence: what you can do before you attend any conference23:20 - Navigating the conference agenda: tools to plan your schedule and how to add value and leave time for decompression and self-care26:45 - Creating branded materials: suggestions for easy connection and communicating key information28:35 - Engaging authentically: how to appear in conversations and what to avoid while conversing with other peopleMentioned In How to Prepare for a Conference to Maximize Your Personal Brand ImpactCorporate Counsel Women of Color Conference Branding Room Only Interview With Laurie Robinson Haden: Shining Brightly - Part 1Branding Room Only Interview With Laurie Robinson Haden: Shining Brightly - Part 2Personal Branding Boosters and Bruisers: Attending ConferencesMaximize Your Event Attendance: 12 Strategies to Amplify Your Personal BrandPersonal Branding Strategy SessionsFollow & Review: If you enjoyed this episode, leave a 5-star review on your favorite podcast platform! Sponsor for this episodePGE Consulting Group LLC empowers individuals and organizations to lead with purpose, presence, and impact. Specializing in leadership development and personal branding, we offer keynotes, custom programming, consulting, and strategic advising—all designed to elevate influence and performance at every level.Founded and led by Paula Edgar, our work centers on practical strategies that enhance professional development, strengthen workplace culture, and drive meaningful, measurable change.To learn more about Paula and her services, go to www.paulaedgar.com or contact her at info@paulaedgar.com, and follow Paula Edgar and the PGE Consulting Group LLC on LinkedIn.

ASCO Daily News
The Gut Microbiome and Immunotherapy: Researching the Connection

ASCO Daily News

Play Episode Listen Later Aug 21, 2025 18:47


Dr. Sumanta (Monty) Pal and Dr. Arielle Elkrief discuss the clinical relevance of the gut microbiome in cancer immunotherapy and the importance of antibiotic stewardship, as well as interventions currently being explored to treat gut dysbiosis and optimize immunotherapy response. TRANSCRIPT Dr. Sumanta (Monty) Pal: Hi everyone, I'm Dr. Monty Pal, welcoming you to the ASCO Daily News Podcast. I'm a medical oncologist. I'm a professor and vice chair of academic affairs at the City of Hope Comprehensive Cancer Center in Los Angeles.  Today we're here to discuss one of my favorite topics, which is the gut microbiome. It's almost hard to avoid the gut microbiome nowadays if you look at medical literature within oncology. It's an emerging phenomenon, but there are a couple of individuals that I would really define as pioneers in the field. And one of them is actually with me today, Dr. Arielle Elkrief, to discuss the clinical relevance of the gut microbiome, particularly amongst patients receiving immunotherapy, although I imagine our conversation today will take many twists and turns. Arielle is an assistant professor and clinician scientist in the Department of Oncology at the University of Montreal, and she is co-director of the CHUM Microbiome Center there.  FYI for the listeners, we have our full disclosures in the transcript of this episode.  Arielle, thank you so much for joining us today. Dr. Arielle Elkrief: Thanks so much, Monty. This is going to be amazing. Dr. Sumanta (Monty) Pal: Well, I have to tell you what sort of inspired me to bring you on as a guest. It was one of many things, but it was this really terrific ASCO Educational [Book] article that you wrote. Now, I have to tell you, I've read all the articles sort of cover to cover in the book, and they're always a wonderful primer, so if our audience is studying for board research or something of that sort, it's a terrific resource to go through. I have to tell you, this piece on the gut microbiome that you wrote is nothing short of a masterpiece. If you read this cover to cover, it's actually going to give you, I think, a sense of the current state and future state of the field. I wanted to start by just sort of beginning with sort of the origin story for a lot of this, which is this association between the gut microbiome and immunotherapy response. This takes us back several years to this pivotal series of papers in Science. Maybe you could walk our audience through that. Dr. Arielle Elkrief: Absolutely. Well, thank you so much for your kind words about the ASCO [Educational] Book. It was a team effort with a lot of key opinion leaders in the field, so I'm really glad to learn that you've liked it.  Moving backwards in terms of how we came to understand that the gut microbiome is essential to priming a response to cancer immunotherapy actually goes back to 2015 and seminal papers that looked at what happens when we take mice that are germ-free mice that have never been exposed to a microbiome. These are mice that are born by cesarean section and essentially live in a bubble. And when we give those mice tumors and treat them, in the first papers with anti-CTLA-4 treatment, we realized that these antibodies don't work at all. And that was the first observation that the presence of a gut microbiome was essential to mounting an anti-cancer immune response. When we supplemented those same mice with beneficial bacteria or feces from responder patients, we were able to restore the response to immunotherapy. And so those were really the first preclinical observations that made us understand the critical role of the microbiome in immunotherapy response. Moving a little bit in the future, we examined the fecal microbiome composition using shotgun metagenomic sequencing in different cohorts of patients with solid tumors, namely lung cancers, kidney cancers, and also skin tumors like melanoma, and found that patients who responded to immunotherapy had a distinct microbiome that was characterized by beneficial bacteria compared to patients who experienced resistance to immunotherapy that had a dysbiotic or diseased microbiome. Dr. Sumanta (Monty) Pal: So, you know, it's interesting, these techniques that we're using to sequence the gut, they're a little bit different. So I wonder if you can give the audience a quick primer on these techniques that you're so well versed in, shotgun metagenomic sequencing, 16S rRNA sequencing. If you had to describe this in 30 seconds, which is a tall task, how would you do that? Dr. Arielle Elkrief: That's a tall task. Much of what we know about the microbiome initially came from a technique called 16S rRNA sequencing. This is a technique that amplifies the 16S region and basically tells you at the genus level what's going on at the level of bacterial composition. This technique is fast, relatively cheap, and can be performed on a laptop computer, which is excellent. The problem is that it's prone to a lot of technical variations. Different primers might give you different results, and you're really limited at the genus resolution. You can't get a good resolution in terms of species, and we're learning that different species from the same genus might have different physiological properties, and the same thing goes at the strain level. So when we really zone in and look at inter-species changes, we're seeing that these actually have specific functions in the host. So that brings us to metagenomic sequencing, which is a whole genome sequencing, next-generation sequencing based method that looks at the whole composition and gives you information not only on bacteria, but you might also get fungal and viral properties. You can zoom in on the strain level. You can also get functional output, so we can examine what the metabolic properties of specific species or strains might look like. The negative aspects of shotgun metagenomic sequencing is that it takes a lot of computational power in order to analyze the results and it might take a little bit longer. And certainly, within the clinical setting, not something that's feasible yet.  And that brings us to more novel point-of-care biomarker tools that we've collaborated in developing along with Dr. Laurence Zitvogel and Dr. Lisa Derosa at Gustave Roussy, that learning from the shotgun metagenomics results designed a probe using quantitative PCR which looks for this specific bacteria we know to be important and developed a ratio of harmful bacteria to beneficial bacteria. This is called the TOPOSCORE, and it actually is able to predict quite nicely the response to immunotherapy using a stool sample and a really good turnaround time of almost 72 hours. Dr. Sumanta (Monty) Pal: That was a perfect overview and a lot of information in a short amount of time. It also makes you take out your high school biology textbooks, doesn't it, to understand that the bacterial ribosome, right, is a different size and shape, and that's what we're sequencing here. But these techniques I think are incredibly important, and I'm glad you actually discussed this, this RT-PCR based strategy of calculating the TOPOSCORE. It lends itself to this phenomenon of dysbiosis, and I think for our audience, that's going to be an important term to understand as time goes on. There's the normal healthy gut and then there's this phenomenon of dysbiosis, which is, I guess, simply put, an unhealthy gut. But tell us about, you know, how often you see dysbiosis in a cancer patient, maybe versus a normal healthy adult. Dr. Arielle Elkrief: So, I think we can split up your question into two parts. One is we know from cohort studies and population level-based studies that the microbiome of patients with cancer is distinct from healthy patients or healthy people. And we know that because of the global composition. We also think that there are diversity metrics that lend themselves to being described as dysbiotic. But we do know that the microbiome of people with cancer is distinct from healthy volunteers. That's the first point.  In terms of how frequently dysbiosis occurs in patients with cancer, it's not very well defined. We know that even among healthy people, there is a certain level of dysbiosis. Laurence in her talk mentioned that to be about 10% to 20%. And the other fascinating component is that when we're thinking about dysbiosis and the cancer associated microbiome, in terms of the species that are enriched, it's quite striking that a lot of these dysbiotic or negative bacteria are also found to be enriched in patients with metabolic disease, like cardiovascular disease, for example. And so it's unclear if dysbiosis is the cause or consequence, but there definitely seems to be a general pattern of disease when looking at the microbiome compared to healthy people. Dr. Sumanta (Monty) Pal: That's interesting. So, I'll tell you, my second favorite portion of your article, and I'll tell you my favorite portion as well in the context of this podcast, but my second favorite part was the section around antibiotic stewardship. You know, the utilization of antibiotics in a very pragmatic fashion amongst our patients. Can you describe why that's so critical in the context of the microbiome? Dr. Arielle Elkrief: Antibiotics can disrupt the gut microbiome composition. We know this from mouse studies, but also cohort studies of patients that are exposed to antibiotics. And most importantly, we know that patients who are exposed to antibiotics, either before or during the immunotherapy period, have significantly worse progression-free survival and overall survival to immunotherapy. And this is true for immunotherapy in the monotherapy setting, but also when combined with chemotherapy. What's striking is that when we look at patients who are just treated with chemotherapy, we don't see the negative outcome of antibiotics on outcome and progression-free survival and overall survival, suggesting that the negative impact of antibiotics on outcomes is really specific to immunotherapy backbones. The other important point is that this negative signal is maintained even after adjusting for standard prognostic variables in the specific malignancies that we're looking at. And then most importantly, at the mechanistic level, we were able to actually pinpoint the mechanism behind this antibiotic related dysbiosis. And we see this with a bloom of negative bacteria which induces a loss of MAd-CAM, which is an endothelial gut checkpoint immune marker, and that causes an efflux of immunosuppressive T cells, which are usually in the gut, to go straight into the tumor where they make the tumor unamenable to an immunotherapy response. And so now we finally have the mechanism as to why antibiotics are harmful and why we need to practice antibiotic stewardship. Dr. Sumanta (Monty) Pal: And just to be clear for the audience, I mean, if a patient needs antibiotics, they need antibiotics. But perhaps it just suggests that, and we have, I suppose, this predilection as oncologists, just for the minor cold or cough or what have you, we maybe should be a little bit more cognizant of whether or not antibiotics are truly necessary. Is that fair? Dr. Arielle Elkrief: Absolutely. So what we're advocating for is antibiotic stewardship, and this is the clear recommendation that we can make. So that means confirming a bacterial infection. If it's there and antibiotics are indicated, to choose the most narrow spectrum for the shortest course and constantly re-evaluate the indication of antibiotics. And of course, we need to work with our colleagues in infectious diseases who've done incredible work in antibiotic stewardship. And all along this process we also need to be mindful of other medications and polypharmacy, such as proton pump inhibitors or narcotics, for example, we think that these other medications which are frequently prescribed in our cancer population can also potentially have negative impacts on the microbiome and immunotherapy response. Dr. Sumanta (Monty) Pal: I think that's a terrific summary and big guidance for the audience.  I promised you I'd tell you my favorite part of your article, and this is this huge table. I think the table is two and a half pages long, if I remember correctly, but it's an awesome table, and I highly recommend our audience to check this out. It lists literally every therapeutic trial for the microbiome under the sun. And so it begins with the approach of fecal microbiota transplant, which I'm going to ask you to tell us about in a second, but it also hinges on a lot of really cool sort of novel therapies, live bacterial products, mixes of different microbial products. Maybe take us through this whole approach of FMT (fecal microbiota transplantation). I actually wasn't aware of the dozens of trials that you listed there in this space. It seems like it's a very active area of research. Dr. Arielle Elkrief: Definitely. So, as you alluded to, FMT or fecal microbiota transplantation is the most well studied and direct way to modify the patient's microbiome. This technique aims to replace the patient's dysbiotic microbiome with that of a healthy microbiome, either from a healthy donor volunteer that's been heavily screened, or from a patient who experienced response to immunotherapy. And, as three landmark studies so far that have been published demonstrated the potential of FMT to reduce primary resistance or secondary resistance to immunotherapy, and this has been in melanoma.  We also recently reported on the results of our FMT-LUMINate trial, which looked at patients with lung cancer and melanoma. Once again, FMT, when combined with immunotherapy was safe and led to a higher proportion of responses than we would normally expect.  We're now also looking at randomized trials that have come out. So the first being the TACITO trial in kidney cancer, which compared FMT plus pembrolizumab and axitinib to placebo in patients with RCC, and again, FMT was safe and feasible and also led to an increased progression-free survival at one year, meeting the study's primary endpoint.  And so, so far, there's a wealth of data really showing the promise of FMT when combined with immunotherapy, and we're now in the process of conducting larger randomized trials, including in melanoma with the CCTG (Canada Cancer Trials Group) in our ME17 or Canbiome2 trial, where we're going to be enrolling 128 patients with metastatic melanoma to receive FMT and standard of care immunotherapy compared to standard of care immunotherapy alone. Dr. Sumanta (Monty) Pal: You're very humble, so I've got to highlight for our audience. This was a mega grant that Arielle received to fund really the largest prospective exploration of FMT that will exist to date. So I'm really excited about that. I wish this was something we could participate in stateside.  Before we jump into the other approach, which is live bacterial products and mixes thereof, where do you see FMT going? I think that one of the perceived challenges with FMT is that it's hard to implement, right? You need to have a really robust framework when it comes to gastroenterology, the preparation's challenging. Is there a way to envision FMT use being more generalized? Dr. Arielle Elkrief: Those are great questions. So we're lucky in Canada to work with pioneers in FMT, Michael Silverman, Saman Maleki, and John Lenehan in London, Ontario, who had this really robust FMT healthy donor screening program, which literally screens for every pathogen under the sun, and we haven't had any problems with feasibility or implementing FMT in Canada. But I think that once we're going to hopefully start doing larger scale, randomized phase three studies, that we might run into problems with scalability. And I think also with regards to reproducibility, and that's the feedback that we're getting from some regulatory authorities, especially at the level of the FDA, where there are some concerns around inter- and intra-donor variability because, of course, we can't guarantee that every fecal sample is going to be the same. So that has really pushed the field to think about other strategies, such as live biotherapeutic products which take modified FMT or bacteria from stools from either healthy donors or from responder patients and basically turn them into drugs that are regulated as drugs and can then be studied in the context of investigational new drugs or products. Dr. Sumanta (Monty) Pal: I like this and, you know, I do think that there's a future for it. We just have to kind of put our heads together and figure out how to get over all of these logistical hurdles, but, you know, I agree, I think your group and others have demonstrated, especially with this trial that you're fanning out all throughout Canada, that it can potentially be done.  This is a topic that could probably go on for another couple of hours, right, especially based on the size of the table that you put together in this brilliant article, but tell us about live bacterial products or LBPs, as we call them these days. What's the current status, what's the future there? And maybe I'll give you less than two minutes here, although again, I realize it's a two-hour topic. Dr. Arielle Elkrief: You're probably better suited to speak about that because you've been one of the pioneers in terms of this. So we can think about LBPs in terms of single strain organisms, like CBM588 for an example, which your group did some amazing work in showing that, in a randomized setting, that this led to better responses than we would expect compared to just work with controls. We also know that LBPs can have multiple strains, up to 30. We're collaborating with a company called Cannabis Bioscience that is actually working on much larger communities of consortia. And so we're really excited about the direction that that's taking in terms of taking these LBPs and developing them from the drug perspective. In addition to LBPs, we know that there are other ways that we can change the microbiome, notably prebiotics, which are compounds which can have a beneficial impact on the microbiome. And one of these is camu camu, which I know your group is leading a clinical trial looking at camu camu and kidney cancer, and we're excited to see how that compares to FMT or LBPs, because that might be a potentially scalable alternative. Dr. Sumanta (Monty) Pal: That's awesome. What a terrific overview, and that was less than two minutes. I don't know how you did it. That's terrific.  Arielle, this has been such an insightful conversation. I just want to thank you for, again, a terrific article in the ASCO Educational Book. I highly recommend all of our listeners to go there and check it out, and also for sharing all these terrific insights on the podcast today. Dr. Arielle Elkrief: Thank you so much, Monty. Dr. Sumanta (Monty) Pal: And thanks to our listeners, too. If you value the insights that you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Thanks, everyone. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:    Dr. Sumanta (Monty) Pal  @montypal Dr. Arielle Elkrief Follow ASCO on social media:     @ASCO on Twitter    ASCO on Bluesky   ASCO on Facebook     ASCO on LinkedIn     Disclosures:    Dr. Sumanta (Monty) Pal:   Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview  Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical  Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis  Dr. Arielle Elkrief: Honoraria: AstraZenica, Bristol-Myers Squibb, Merck, EMD Serono Consulting or Advisory Role: Bristol-Myers Squibb Research Funding (Inst.): Kanvas Bioscience, AstraZeneca, Merck Other Relationship: Royal College of Surgeons and Physicians of Canada, Cedar's Cancer Center (Henry R. Shibata Fellowship), Canadian Institutes of Health Research (CIHR)

Launch Your Box Podcast with Sarah Williams | Start, Launch, and Grow Your Subscription Box
214: Stop Researching. Start Selling Your Subscription Box.

Launch Your Box Podcast with Sarah Williams | Start, Launch, and Grow Your Subscription Box

Play Episode Listen Later Aug 20, 2025 37:42


If you've been “almost ready” to launch your subscription box for months – or even years – this episode of the Launch Your Box Podcast is for you. I get it. I spent 18 months sitting on my own subscription box idea, watching others launch, endlessly researching, tweaking, and dreaming. I thought I was preparing. But when I finally launched, I learned more in that first month of taking action than I had in all those months of planning. The truth? All that research, note-taking, and idea-tweaking feels productive… But it's keeping you from what you really want: customers, sales, and momentum. In this episode of the Launch Your Box Podcast, I'll help you break out of perpetual learning mode so you can finally start selling your subscription box.  How to Tell If You're Stuck in Perpetual Research Mode Some of the biggest indicators include: You've gathered endless information but haven't acted on it. Your launch date keeps moving. You redesign your branding more than you talk to potential customers. You're constantly switching your box idea after seeing others' boxes. You're waiting for the “perfect” product before you launch. Staying in research mode feels safe. There's no risk of rejection, no hard deadlines, and no uncomfortable decisions. But every week you stay there is a week without customers, feedback, or income. The Hidden Reasons You Haven't Launched Your Subscription Box Being “not ready” is rarely about needing more time or more information. Often, what's really keeping you stuck is one of these: Fear of Failure – Worrying no one will buy or that people won't like your box. Fear of Success – Wondering how you'll handle it if things actually take off. Perfectionism – Believing everything must be flawless before you launch. Comparison – Feeling behind because your box doesn't look like someone else's Year 5 version. Comfort Zone + Lack of Clarity – Staying in familiar territory instead of testing your idea with real people. In the episode, I share stories from my own business journey and why messy action is always better than perfect inaction. You can't research your way into a successful subscription box business. You have to sell your way there. Imagine 30 days from now: your first boxes shipped, real customer feedback in hand, and a clear plan for month two. That only happens if you start now. Stop waiting for perfect. Start building the business you've been dreaming about. Join me in all the places:     Facebook Instagram Launch Your Box with Sarah Website  Are you ready for Launch Your Box? Our complete training program walks you step by step through how to start, launch, and grow your subscription box business. Join the waitlist today! 

School Of Awesome Sauce with Greg Denning
So Many Dreams, So Little Time: A Parent's Guide to Choosing Which Goals Matter Most Right Now

School Of Awesome Sauce with Greg Denning

Play Episode Listen Later Aug 19, 2025 60:51


Do you ever feel like you have a "million dreams and not enough time" to chase them all? As a parent, the challenge is even greater—you want financial freedom, family adventures, strong relationships, better health, and so much more. But where do you even start?In this episode, Greg and Rachel Denning share their 5-step process for choosing which dreams matter most right now. They reveal how to prioritize goals without sacrificing what matters most—your marriage, your kids, your health, and your peace of mind.Key Takeaways:✅ Write down and prioritize ALL your dreams✅ Balance ambition with family life✅ Follow intuition and interests as guideposts✅ Use urgency, energy, and alignment filters to choose what to pursue✅ Avoid the trap of sacrificing relationships for successWhether you dream of traveling the world, building a business, or creating a family legacy, this episode will help you gain clarity, simplify your focus, and start moving forward today.If you've ever asked, “Where do I start?”—this is the roadmap you've been looking for.✨ Memorable Quotes

Gangland Wire
Hollywood and the Chicago Boys: Stone Wallace on Mobsters in Tinseltown

Gangland Wire

Play Episode Listen Later Aug 18, 2025 28:23 Transcription Available


In this episode of Gangland Wire, retired Kansas City intelligence detective Gary Jenkins sits down with writer and mob historian Stone Wallace—a man whose path has crossed acting, broadcasting, boxing, and a lifelong fascination with organized crime. The focus of today's conversation is Stone Wallace's latest book, Hollywood and the Chicago Boys, which uncovers how the Chicago Outfit quietly moved in on Hollywood in the 1930s. With Prohibition fading, figures like Frank Nitti and Tony Accardo shifted their sights to new rackets in film unions, projection booths, and studio lots. Stone Wallace's obsession with the mob began at age seven with a library book on the 1920s. It lit a fire that would eventually lead Wallace to explore the violent glamour of the underworld in both fiction and nonfiction. Stone Wallace shares how he created the fictional studio boss Sam Bast, modeled after several real-life moguls, and how mob-connected actors like George Raft blurred the lines between movie star and made man. From behind-the-scenes extortion to real-life gangland enforcers like Jack “Machine Gun” McGurn, this episode connects the dots between celluloid dreams and street-level muscle. Stone Wallace's Amazon author page.

Business & Personal Development with Chris Haroun
How to invest in different sectors, Which 10 companies in the financial sector are worth researching, Tech jobs that won't be affected by AI and more.

Business & Personal Development with Chris Haroun

Play Episode Listen Later Aug 16, 2025 114:47


This episode is a compilation of answers to YOUR questions that were asked directly from my listeners who attend my weekly business education YouTube live webcast. Topics covered include: How to invest in different sectors, Which 10 companies in the financial sector are worth researching, Tech jobs that won't be affected by AI and more.   Refer to chapter marks for a complete list of topics covered and to jump to a specific section. Download my free "Networking eBook": www.harouneducation.comAttend my weekly YouTube Live every Thursday's 8am-11am PT. Subscribe to my YouTube Channel to receive notifications. Learn more about my MBA Degree ProgramConnect with me: YouTube: ChrisHarounVenturesCompleteBusinessEducationInstagram @chrisharounLinkedIn: Chris HarounTwitter: @chris_harounFacebook: Haroun Education Ventures  TikTok: @chrisharoun300How to forecast a P/E ratio

EatWild Podcast
EatWild 100 - Cougars Up Close - Researching cougar behaviour with wildlife biologist Julie Thomas

EatWild Podcast

Play Episode Listen Later Aug 16, 2025 61:41


I've always known that cougars tend to avoid humans, with only a few close calls while sneaking around in the woods. However, this summer has seen several unusual encounters with cougars in Whistler and Squamish, including instances of cougars stalking hikers and chasing mountain bikers in popular recreation areas. I was curious about the reasons behind this behaviour, so I reached out to wildlife biologist Julie Thomas. In our conversation, Julie discusses her research on cougars in central British Columbia, focusing on their predator-prey relationship with caribou. She explains how changes in the landscape impact cougar behaviour, their hunting techniques, and their adaptability to various environments. We also delve into field research methods, including the process of capturing and collaring cougars, as well as the complexities of human-cougar interactions, especially in areas where cougars have been sighted near popular trails. Julie shares insights from her experiences and emphasizes the importance of understanding these magnificent creatures in the context of conservation and wildlife management. I also share a couple of my close brushes with cougars in the wild.   You can follow Julie here for more on her research and catch amazing cougar footage @wild_juliethomas on Instagram.    Check out the latest EatWild Online Course - iHunter App Field Guide: Tools and tactics for successful hunts The iHunter App supports the Eatwild Podcast and other programs. It is an essential tool for making you more comfortable in the woods. The app's mapping layers, navigation tools, and hunting regulations are packed into it to give you the information you need on your next adventure.  Stop in at Beere Brewing and take advantage of a 10% discount on your purchase. Use the code EATWILD10 on your next purchase. Beere makes a great selection of bright, crisp beers perfect for the patio or around the campfire.  

The Astrology Podcast
Comets in Astrology

The Astrology Podcast

Play Episode Listen Later Aug 15, 2025 114:07


In episode 503 of The Astrology Podcast astrologer Rod Chang joins me to discuss the long and fascinating history of comets in astrology, how astrologers viewed them as omens in ancient times, and creating a new foundation for interpreting them today. While comets are a notable astronomical phenomenon and are famous in legends from ancient times as powerful omens, there has been very little discussion about their meaning or use in modern astrology. Part of the reason for this is that they appear so infrequently, are difficult to calculate, and are not included in most astrology software, which has led to them being largely overlooked by contemporary astrologers. We begin the discussion by exploring the long history of comets in astrology, noting the contrast between the Western tradition and the Chinese tradition. In the West, research into comets was set back for centuries by Aristotle's mistaken belief that they were merely atmospheric phenomena. In the Chinese tradition, however, comets were meticulously documented for thousands of years, where they were often referred to as "broom stars" that could sweep away the old government or indicate the need for reform. This eventually led to a rich history of astrological interpretation, which we are only now beginning to recover and understand. During the course of the episode we talk about what comets are from an astronomical perspective, as well as how their erratic and unpredictable nature became a key part of their astrological interpretation. Traditionally comets were interpreted as omens that signified major disruptions, the death of prominent people, and important turning points in history. Their meaning was often derived from their visual appearance, such as their color or the shape of their tail. While often viewed as negative omens that coincided with natural disasters or the death of rulers, there are also instances where they were interpreted positively. Towards the end of the episode we discuss how contemporary astrologers are now in a much better position to study comets, with new tools that allow us to calculate their positions and go back and research what was happening in the world when major comets appeared in the past. This is a large part of the focus of Rod's new book titled Comets in Astrology, where he identifies some of the most important "Great Comets" in history and documents the events that coincided with their appearance. We hope that this discussion provides a good foundation for a subject that will become an exciting new area of research in astrology in the years to come. Rod's book was just released August 13, and you can get it now: Comets in Astrology on Amazon You can find out more information about Rod on his website: RodChang.com This episode is available in both audio and video versions below. Timestamps 00:00:00 Introduction 00:01:05 Rod's journey into studying comets 00:02:40 Why comets are overlooked in modern astrology 00:07:09 What is a comet? 00:10:04 Short-period vs. long-period comets 00:16:55 Erratic and unpredictable quality of comets 00:19:18 Aristotle's error vs. Chinese documentation 00:24:30 Edmond Halley, Brahe, and Kepler 00:28:58 Recent comets: Pons-Brooks 00:33:52 Decline of astrology hindered comet research 00:36:39 Researching historical comets and mundane events 00:39:01 What defines a “Great Comet” 00:51:04 Chinese “broom stars” and political significance 01:01:06 Comets as omens 01:11:47 Death of prominent people 01:15:02 Mark Twain and Halley's Comet 01:25:52 Observational astronomy 01:36:18 Comet's tail and directionality 01:40:03 Positive interpretations of comets 01:43:27 Setting a foundation for comet research 01:48:11 Rod's upcoming work, website, and classes 01:51:29 Concluding remarks Watch the Video Version of This Episode https://www.youtube.com/watch?v=U-UtgNIRCnY –

Spybrary
The Second Traitor with Alex Gerlis

Spybrary

Play Episode Listen Later Aug 14, 2025 50:51


In this episode of Spybrary, host Shane Whaley interviews author Alex Gerlis about his latest novel, The Second Traitor, book 2 in the spy series which is set against the backdrop of World War II and the early Cold War. They discuss the complexities of writing historical fiction, the importance of research, and the intricate character dynamics within the story. Gerlis shares insights into the historical events that inspired his work, including Operation Sea Lion, the Invasion Warning, Sub-Committee and the role of German intelligence (Abwehr). The conversation also touches on the balance between action and intrigue in spy fiction, as well as the challenges of writing sensitive topics and sex scenes. Highlights of our conversation with author Alex Gerlis. The Second Traitor is the second book in a four-part series. Readers can jump into the second book without reading the first. Historical accuracy is crucial in writing spy fiction. Operation Sea Lion was a significant but ultimately failed Nazi plan. Were the Abwehr sending second-rate spies to Britain? Character development is key to engaging storytelling. Gerlis prefers to allude to intimate scenes rather than describe them in detail. Researching real locations adds authenticity to the narrative. The Invasion Warning Subcommittee was a real organization during WWII. Gerlis's writing process is flexible and not overly planned.   If you enjoyed this episode, please consider leaving us a rating and review. Your support helps more spy fiction fans discover the show. Don't forget to follow, share, and stay tuned for more tales from the world of espionage. Join us for this enthralling conversation and then connect with your fellow espionage aficionados in our online community to share your thoughts on Alex Gerlis's spy novels

Daily Stock Picks
✅Alpha Picks Playbook: Beat the S&P by Researching, Not Over‑Trading | Quant‑Driven Top Stocks, Bullish IPO and Strategies

Daily Stock Picks

Play Episode Listen Later Aug 14, 2025 34:27


A great episode on actual NUMBERS - trading takes away long term gains! Plus some great stocks! Here are the links to all the sales: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SAVE ON TRENDSPIDER - GET THE ANNUAL SUBSCRIPTION TO GET MY 4 HOUR ALGORITHM ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Dear Nikki - A User Research Advice Podcast
Researching for Real Life | Loren Flores & Kathryn Ambroze (JPMorgan Chase)

Dear Nikki - A User Research Advice Podcast

Play Episode Listen Later Aug 8, 2025 31:11


Listen now on Apple, Spotify, and YouTube.—Loren is a UX Researcher with over 8 years of experience designing user-centered financial solutions. She's passionate about uncovering actionable insights that bridge user needs with business objectives, and specializes in transforming complex behaviors into strategies that elevate digital experiences. Loren currently works at JPMorgan Chase as a Lead UX Researcher for digital commerce solutions. Over her time at Chase she has worked across several organizations, getting to know a wide variety of customer-facing and employee-facing products and services giving her a unique insight into how the customer views Chase as a whole.Kathryn is a behavioral neuroscientist with experience in consumer research and methodological innovation. She earned her Bachelors in Neuroscience and Business from Muhlenberg College and her Masters in Behavioral and Decision Sciences at the University of Pennsylvania. She currently works at JP Morgan Chase as a User Researcher, with a focus on methodological development, infusing behavioral science and design thinking into the customer experience.In our conversation, we discuss:* What end-to-end research actually means in practice and why it starts before users ever touch your product.* How to use habit loops to map and influence real customer behavior without forcing change.* The power of live account interviews for breaking out of prototype fantasyland.* Strategies for building alignment and shifting stakeholders from “I need” to “we're solving.”* How internal playbooks, role-play exercises, and empathy maps help teams stay grounded in real life.Some takeaways:* End-to-end research isn't just a longer study, but a wider lens. Loren and Kathryn define end-to-end research as everything from a customer's initial intent to what happens after they close the product. It's not just about usability or funnel drop-off, but about how their lives influence how they interact with your product. To get real insight, you have to look outside the interface and understand what's happening before, during, and after each interaction. That kind of zoomed-out context changes the questions you ask and the recommendations you make.* Customers don't live inside your product and they won't change their habits for you. Many organizations build with the assumption that users will adapt. They won't. Through live account research, Loren uncovered how users ignore offers, stick to their routines, and reject anything that adds complexity. Kathryn explains how habit loops (cue → routine → reward) help teams understand why users behave the way they do, and why your product needs to slot into existing routines, not disrupt them.* Usability labs are structured, focused, and quiet. Real life is not. That's why live account research can be so powerful; users bring their own data, context, and mess. Watching someone navigate a real account reveals things no A/B test or journey map ever could, especially when paired with tools like empathy maps that capture what people are saying, doing, thinking, and feeling.* To build cross-team alignment, make the customer the common ground. When products span multiple teams, priorities clash. Loren uses design rationale briefs and vision statements to realign teams around what the customer wants, not just what each team needs. Kathryn emphasizes the importance of shared language and moving from “I need” to “we're building.” Getting people into the same room, physically or virtually, and grounding them in the customer's perspective is what turns politics into partnership.* If you want teams to understand context, you have to simulate real life. Kathryn runs role-playing workshops where stakeholders juggle real-life distractions while interacting with a product. It's a reminder that customers are busy, stressed, and multitasking, and your product has to work under those conditions. Loren adds that this mindset shift helps counter the overconfidence teams can get from testing in perfect research environments. Their advice: don't just study what customers say, watch what they actually do in the wild.Where to find Loren:* LinkedInWhere to find Kathryn: * LinkedInStop piecing it together. Start leading the work.The Everything UXR Bundle is for researchers who are tired of duct-taping free templates and second-guessing what good looks like.You get my complete set of toolkits, templates, and strategy guides. used by teams across Google, Spotify, , to run credible research, influence decisions, and actually grow in your role.It's built to save you time, raise your game, and make you the person people turn to—not around.→ Save 140+ hours a year with ready-to-use templates and frameworks→ Boost productivity by 40% with tools that cut admin and sharpen your focus→ Increase research adoption by 50% through clearer, faster, more strategic deliveryInterested in sponsoring the podcast?Interested in sponsoring or advertising on this podcast? I'm always looking to partner with brands and businesses that align with my audience. Book a call or email me at nikki@userresearchacademy.com to learn more about sponsorship opportunities!The views and opinions expressed by the guests on this podcast are their own and do not necessarily reflect the views, positions, or policies of the host, the podcast, or any affiliated organizations or sponsors. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.userresearchstrategist.com/subscribe

The Creative Penn Podcast For Writers
Researching And Writing Family History Or Genealogy With TL Whalan

The Creative Penn Podcast For Writers

Play Episode Listen Later Aug 4, 2025 57:37


Are you curious about the lives of your ancestors? What secrets might be hiding in your family tree, and where would you even begin to look for them? How do you turn dusty records and vague family stories into a compelling book for others to read? T.L. Whalan shares how she researched and wrote a […] The post Researching And Writing Family History Or Genealogy With TL Whalan first appeared on The Creative Penn.

Real Estate Investing Abundance
How to Stand Out in the STR Market with Mark Lumpkin of STR Cribs - Episode - 532

Real Estate Investing Abundance

Play Episode Listen Later Aug 1, 2025 28:18


We'd love to hear from you. What are your thoughts and questions?In this conversation, Allen Lomax and Mark Lumpkin delve into the world of short-term rentals, discussing the importance of partnerships, the unique opportunities in this investment strategy, and the evolving expectations of guests. They explore the regulatory challenges facing the industry and the significance of building strong client relationships. Mark shares insights on market trends and how investors can navigate competition by focusing on unique experiences.Main Points:Choosing the right partner is crucial for success.Short-term rentals can yield significantly higher income than long-term rentals.Building strong relationships with clients leads to better outcomes.Quality over quantity in client relationships is essential.Regulatory challenges are a major concern for short-term rentals.The demand for short-term rentals is growing year over year.Guests are increasingly viewing properties as part of their vacation experience.Researching local market needs is vital for success.Unique properties face less competition in the market.STR Cribs specializes in helping clients set up short-term rentals.Connect with Mark Lumpkin:mlumpkin@strcribs.comwww.strcribs.comhttps://www.linkedin.com/in/mark-lumpkin-84b173142/https://www.instagram.com/strcribs_/

The Remarkable Leadership Podcast
The Science of Leadership with Margaret Moore and Jeffrey Hull

The Remarkable Leadership Podcast

Play Episode Listen Later Jul 31, 2025 40:03 Transcription Available


What are some practical ways to make an impact as a leader? In this episode, Kevin welcomes Margaret Moore and Jeffrey Hull to discuss how leaders can close the gap between science and real-world application. Margaret and Jeffrey translated hundreds of leadership studies into nine capacities. These are grouped into three levels: self, relationships with others, and the larger organizational and societal impact. They share what it means to lead intentionally, develop agility and authenticity, and build psychologically safe environments. They also talk about concepts like the "quiet ego," balancing compassion and strategy, and why conscious leadership underpins all other capacities. Listen For 0:00 Introduction and Framing the Conversation 1:16 About the Podcast and Live Opportunities 1:48 Kevin Introduces His Book Flexible Leadership 2:15 Guest Introductions Margaret Moore and Jeffrey Hull 3:14 Why the Word “Impact” 5:26 How the Book Came to Be 8:09 Researching the Research 13:28 Three Segments of Leadership Capacities 17:32 The 3 Self Focused Capacities 19:39 The 3 Team or Other Focused Capacities 23:39 The 3 Organization Focused Capacities 27:48 Most Misunderstood Capacities 30:12 The Concept of the Quiet Ego 32:42 Book Takeaways and Closing Reflections 35:03 What They're Reading 37:04 Where to Learn More 38:24 Kevin's Final Challenge Now What Their Story: Jeffrey Hull, PhD, and Margaret Moore, MBA are the authors of The Science of Leadership: Nine Ways to Expand Your Impact. Jeffery has focused on leadership for over 30 years, as an HR leader with multiple corporations, cofounder of a leadership development consultancy, nonprofit executive director, and coach to leaders across the globe. He brings years of translating science into leadership as a consultant, psychologist, and teacher at New York University and Harvard Medical School. In writing this book, Jeff is excited to see his chosen professions—leadership and coaching—getting the scientific attention and application they deserve. Margaret blends leadership, coaching, and science, including thirty years in C-suite roles, co-leading four successful start-ups in biotechnology and coaching, and two decades of professional coaching and coach training. For 25 years, she has been a prolific translator of science into coaching, training, and leadership practice. Margaret's vision for this book is to help bring scientists, leaders, and coaches together to foster leadership excellence and support everyday leaders far and wide. https://www.scienceofleadership.com/ https://www.linkedin.com/in/jeffreywhull/ https://www.linkedin.com/in/coachmeg/ This Episode is brought to you by... Flexible Leadership is every leader's guide to greater success in a world of increasing complexity and chaos.  Book Recommendations The Science of Leadership: Nine Ways to Expand Your Impact by Jeffrey Hull and Margaret Moore  The Transformative Self: Personal Growth, Narrative Identity, and the Good Life (Explorations in Narrative Psychology) by Jack J. Bauer  The Trauma of Everyday Life by Mark Epstein M.D Thoughts Without A Thinker: Psychotherapy from a Buddhist Perspective by Mark Epstein Rise Above: Overcome a Victim Mindset, Empower Yourself, and Realize Your Full Potential by Scott Barry Kaufman PhD James by Percival Everett Like this? Cracking the Leadership Code with Alain Hunkins Connecting with Others Through Listening with Ximena Vengoechea Join Our Community If you want to view our live podcast episodes, hear about new releases, or chat with others who enjoy this podcast join one of our communities below. Join the Facebook Group Join the LinkedIn Group   Leave a Review If you liked this conversation, we'd be thrilled if you'd let others know by leaving a review on Apple Podcasts. Here's a quick guide for posting a review. Review on Apple: https://remarkablepodcast.com/itunes    Podcast Better! Sign up with Libsyn and get up to 2 months free! Use promo code: RLP  

Workplace Innovator Podcast | Enhancing Your Employee Experience | Facility Management | CRE | Digital Workplace Technology
Ep. 362: “Have a Data Strategy” – Elevating Employee Experiences by Researching the Future at Work with Kyle de Bruin of Leesman

Workplace Innovator Podcast | Enhancing Your Employee Experience | Facility Management | CRE | Digital Workplace Technology

Play Episode Listen Later Jul 29, 2025 25:31


Kyle de Bruin is Managing Director at Leesman where he is passionate about measuring and analyzing the experiences of employees in their places of work. Mike Petrusky asks Kyle about how high-performance offices deliver a great employee experience and they review lessons learned from the past five years of workplace change. The lack of variety in office design is a significant challenge, as employees are staying at their desks due to the increased use of video calls and the need for private conversations. Kyle believes that the facility management and corporate real estate industry is data-rich but insights-poor, so he hopes AI advancements can help organize and analyze unstructured data. The value of real estate assets should not solely be measured by occupancy rates and workplace leaders need to focus on creating spaces where employees can focus and be productive, so Mike and Kyle offer the advice and inspiration you need to be a Workplace Innovator! Take the Eptura™ Podcast Survey: https://forms.office.com/r/jY577CbNcx Connect with Kyle on LinkedIn: https://www.linkedin.com/in/kyledebruin/ Learn more about Leesman: https://www.leesmanindex.com/ Read the “Lessons Learned” article Kyle referenced: https://www.leesmanindex.com/articles/redefining-the-workplace-why-employee-experience-matters/ Discover free resources and explore past interviews at: https://www.workplaceinnovator.com/ Learn more about Eptura™: https://eptura.com/ Connect with Mike on LinkedIn: https://www.linkedin.com/in/mikepetrusky/  

Mark Bell's Power Project
TRT Explained: The Science of How To Boost Testosterone

Mark Bell's Power Project

Play Episode Listen Later Jul 28, 2025 109:33


Boost your testosterone and transform your health with this deep dive into the world of TRT! Mark Bell and Nsima Inyang hang out with Chase Irons on Mark Bell's Power Project Podcast to break down the science behind testosterone replacement therapy, hormones, and optimizing your body.They tackle everything from managing TRT dosages, diet, and cardio to avoid side effects like bloating and high blood pressure, to strategies for building muscle and burning fat. Chase shares his insights on using peptides, GLP-1s, HGH, and even methylene blue for recovery and energy.Follow Chase on IG: https://www.instagram.com/chaseirons/Special perks for our listeners below!

The Grimerica Show
#718 - Michael Donnellan and Nick Spratt. Atlantica - The Lost City Found

The Grimerica Show

Play Episode Listen Later Jul 15, 2025 124:41


Interview starts at 33:05 Michael and Nick join us to chat about Atlantis, Atlantica - Michael's docuseries and the Azores as another location.   Michael talks about the 8 years of work, working at Giza, scanning techniques, shipwrecks, visual effects and this growing community. Then we get into what they have found of the coast of Spain. Plato, underwater currents, old explorers, ancient mining, Templars are also all discussed.   Since 2015, Michael has spearheaded multidisciplinary underwater and satellite expeditions along southern Spain's Atlantic coast with Merlin Burrows. Their explorations have uncovered concentric ruins off Cádiz that mirror Plato's description of Atlantis—circular city walls, a central temple, harbor structures—using sonar, LiDAR, dives, and lab-validated ancient concrete samples His efforts are captured in the three-part docuseries Atlantica: The Discovery of Atlantis, premiered at the South International Series Festival in Cádiz with a 10-minute standing ovation. The series assembles archaeological, geological, and historical evidence suggesting Atlantis may lie buried off the Andalusian coast http://www.ingeniofilms.com/films/atlantica/ https://www.instagram.com/michaeldonnellan_atlantica/   Nick Spratt. Researching the Azores as the spot for Atlantis and our tour guide for Contact at the Cabin in the Azores with Randall Carlson https://www.youtube.com/@Jungcheese1080 https://www.instagram.com/nickaspratt/   Links to stuff we chatted about in the intro: https://nevermoremedia.substack.com/p/crow-update-71425?publication_id=787156&post_id=168341554&triggerShare=true&isFreemail=true&r=24pqe&triedRedirect=true   https://www.amazon.ca/Unlearned-School-Failed-What-About-ebook/dp/B0FH5R7K7P/ref=sr_1_1?sr=8-1   Become a Lord or Lady with 1k donations over time. And a Noble with any donation. Leave Serfdom behind and help Grimerica stick to 0 ads and sponsors and fully listener supported. Thanks for listening!! Help support the show, because we can't do it without ya.   Support the show directly: https://grimericacbd.com/ CBD / THC Gummies and Tinctures http://www.grimerica.ca/support https://www.patreon.com/grimerica http://www.grimericaoutlawed.ca/support www.Rokfin.com/Grimerica   https://www.eventbrite.com/e/experience-the-ultimate-hunting-adventure-in-alberta-canada-tickets-1077654175649?aff=ebdsshcopyurl&utm-campaign=social&utm-content=attendeeshare&utm-medium=discovery&utm-term=organizer-profile&utm-share-source=organizer-profile   The Eh- List site. Canadian Propaganda Deconstruction https://eh-list.ca/ The Eh-List YouTube Channel: https://youtube.com/@theeh-list?si=d_ThkEYAK6UG_hGX Adultbrain Audiobook YouTube Channel: https://www.youtube.com/@adultbrainaudiobookpublishing https://grimericaoutlawed.ca/The newer controversial Grimerica Outlawed Grimerica Show Check out our next trip/conference/meetup - Contact at the Cabin www.contactatthecabin.com Our audio book website: www.adultbrain.ca www.grimerica.ca/shrooms and Micro Dosing Darren's book www.acanadianshame.ca Grimerica on Rumble: https://rumble.com/c/c-2312992 Join the chat / hangout with a bunch of fellow Grimericans Https://t.me.grimerica https://www.guilded.gg/i/EvxJ44rk   Leave a review on iTunes and/or Stitcher: https://itunes.apple.com/ca/podcast/grimerica-outlawed http://www.stitcher.com/podcast/grimerica-outlawed Sign up for our newsletter https://grimerica.substack.com/ SPAM Graham = and send him your synchronicities, feedback, strange experiences and psychedelic trip reports!! graham@grimerica.com InstaGRAM https://www.instagram.com/the_grimerica_show_podcast/ Tweet Darren https://twitter.com/Grimerica Can't. Darren is still deleted. Purchase swag, with partial proceeds donated to the show: www.grimerica.ca/swag Send us a postcard or letter http://www.grimerica.ca/contact/ Episode ART - Napolean Duheme's site http://www.lostbreadcomic.com/ MUSIC https://brokeforfree.bandcamp.com/ - Something Old Felix's Site sirfelix.bandcamp.com - Should I