Podcasts about ubiquitylation

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.24.550360v1?rss=1 Authors: del Pino, R. C., Zoltner, M., Yamada, K., Butterfield, E. R., Field, M. Abstract: Post-translational modifications (PTMs) modulate protein function, with ubiquitylation a pre-eminent example with major roles in protein turnover. Ubiquitylation utilises a ligase enzyme cascade for conjugation of ubiquitin to client proteins and cullin-RING ligases are amongst the most complex known. We reconstructed evolution of cullin-RING E3 ubiquitin ligases across eukaryotes and experimentally characterised two cullin complexes in trypanosomatids, a taxon highly divergent from animals and fungi. We find considerable diversity within cullins and, in particular, trypanosomatids share only a minority of cullins with other lineages. Furthermore, we identify expansions in cullin client adaptor protein families, novel client adaptors and demonstrate client specificity. Finally we show that ornithine decarboxylase (TbODC), an important target of the drug trypanosome eflornithine, is a substrate for TbCul-A and overturn earlier models for eflornithine specificity. These studies highlight lineage-specific roles for cullin E3s and their contributions towards eukaryotic complexity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

This episode is also available as a blog post: http://biopatrika.com/2021/04/02/interview-ubiquitylation-mitochondria-disorder/

Mario Rossi,Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET, Partner Institute of the Max Planck Society Polo Científico Tecnológico, Buenos Aires, ARGENTINA speaks on "Role of protein Ubiquitylation in tumor-cell migration and invasion". This seminar has been recorded by ICGEB Trieste

Guy Salvesen explains how arsenic trioxide treatment switches which SUMO variant is conjugated to an oncoprotein, thus triggering its degradation.

Venuprasad Poojary explains how the ubiquitin ligase Itch prevents chronic skin inflammation.

Vitezslav Bryja, Reinoud de Groot, and Rik Korswagen discovered that Huwe1 ubiquitylates Dishevelled to negatively regulate Wnt signaling.

Fri, 7 Feb 2014 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/18162/ https://edoc.ub.uni-muenchen.de/18162/1/Burkert-Kautzsch_Cornelia.pdf Burkert-Kautzsch, Cornelia ddc:540, ddc:500

Michaela Gack discusses how the deubiquitinase USP15 promotes interferon production to prolong the antiviral response.