Podcasts about signaling

Our 210th episode with a summary and discussion of last week's big AI news! Recorded on 05/23/2025 Hosted by Andrey Kurenkov and Jeremie Harris. Feel free to email us your questions and feedback at contact@lastweekinai.com and/or hello@gladstone.ai Read out our text newsletter and comment on the podcast at https://lastweekin.ai/. Join our Discord here! https://discord.gg/nTyezGSKwP In this episode: Google's Gemini diffusion technology showcases significant improvements in speed and efficiency for generating text, potentially revolutionizing the auto-regressive generation paradigm. Anthropic activates AI Safety Level 3 protections for Claude Opus 4, implementing robust measures such as bug bounties, synthetic jailbreak data, and preliminary egress bandwidth controls to mitigate bio-risk threats. OpenAI responds to the California Attorney General, refuting claims by the not-for-private-gain coalition and defending their controversial restructuring plans amidst ongoing criticism. Mistral delays the release of its Llama 4 Behemoth model due to training challenges, while Meta faces similar obstacles in rolling out its large-scale AI models, signaling difficulties in reaching frontier level performance. Timestamps + Links: (00:00:00) Intro / Banter (00:01:43) News Preview Tools & Apps (00:02:58) Anthropic's new Claude 4 AI models can reason over many steps (00:09:58) Google Unveils A.I. Chatbot, Signaling a New Era for Search (00:14:04) Google rolls out Project Mariner, its web-browsing AI agent (00:16:40) Veo 3 can generate videos — and soundtracks to go along with them (00:21:26) Imagen 4 is Google's newest AI image generator (00:23:15) Google Meet is getting real-time speech translation (00:25:36) Google's new Jules AI agent will help developers fix buggy code (00:26:43) GitHub's new AI coding agent can fix bugs for you (00:28:50) Mistral's new Devstral model was designed for coding Applications & Business (00:29:53) OpenAI Unites With Jony Ive in $6.5 Billion Deal to Create A.I. Devices (00:36:10) OpenAI's planned data center in Abu Dhabi would be bigger than Monaco (00:41:18) LM Arena, the organization behind popular AI leaderboards, lands $100M (00:45:21) Nvidia CEO says next chip after H20 for China won't be from Hopper series (00:46:39) Google's Gemini AI app has 400M monthly active users (00:51:15) AI Servers: End demand intact, but rising gap between upstream build and system production (2025.5.18) Projects & Open Source (00:53:46) Meta Is Delaying the Rollout of Its Flagship AI Model Research & Advancements (00:57:53) Gemini Diffusion (01:03:07) Chain-of-Model Learning for Language Model (01:09:16) Seek in the Dark: Reasoning via Test-Time Instance-Level Policy Gradient in Latent Space (01:15:38) Two Experts Are All You Need for Steering Thinking: Reinforcing Cognitive Effort in MoE Reasoning Models Without Additional Training (01:20:16) Lessons from Defending Gemini Against Indirect Prompt Injections (01:23:35) How Fast Can Algorithms Advance Capabilities? (01:30:20) Reinforcement Learning Finetunes Small Subnetworks in Large Language Models Policy & Safety (01:31:12) Exclusive: What OpenAI Told California's Attorney General (01:38:25) Activating AI Safety Level 3 Protections

This week, we take a field trip to Google and report back about everything the company announced at its biggest show of the year, Google I/O. Then, we sit down with Google DeepMind's chief executive and co-founder, Demis Hassabis, to discuss what his A.I. lab is building, the future of education, and what life could look like in 2030.Guest:Demis Hassabis, co-founder and chief executive of Google DeepMindAdditional Reading:At Google I/O, everything is changing and normal and scary and chillGoogle Unveils A.I. Chatbot, Signaling a New Era for SearchGoogle DeepMind C.E.O. Demis Hassabis on the Path From Chatbots to A.G.I.We want to hear from you. Email us at hardfork@nytimes.com. Find “Hard Fork” on YouTube and TikTok. Unlock full access to New York Times podcasts and explore everything from politics to pop culture. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify.

On today's Friday Q&A we cover: 1:30 Should I build a new house or buy an existing one? 14:19 My YouTube channel is struggling. What now? 30:13 Should I move with my girlfriend to the USA for a work assignment? 57:10 How can I apply Signaling Theory to modern dating? 1:13:41 Should I switch jobs to one that seems better but has less potential? 1:23:45 Should I pay cash for a house or borrow for it? 1:33:55 How do I move from Canada to the USA? 1:42:24 Should I add a CFP to my CPA designation? Joshua Please join us next week! https://patreon.com/radicalpersonalfinance 

Mark Thornton appears on Liberty and Finance with Elijah K. Johnson. They discuss the economic implications of the historically high gold-silver ratio. Dr. Thornton emphasizes the importance of historical data and Austrian economic principles in understanding crises. He also stresses the need for practical financial education, as government responses are failing to address core economic problems, leaving markets vulnerable to heightened volatility.The original interview is available on YouTube. For more information, visit Libertyandfinance.com.

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Mike Blake is the founder of High Score Strategies, with over 26 years of experience in business valuation and M&A markets. He specializes in advising small to medium-sized businesses (SMBs) on increasing their valuations. Mike is passionate about the relationship between pricing and value, and how effective pricing strategies can significantly impact a company's worth. In this episode, Mike shares his insights on how pricing affects valuation, the importance of differentiation in a competitive market, and the shift from growth to profitability in business models. Together, they explore the concept of context-driven pricing, the significance of signaling in pricing strategies, and how companies can leverage their unique data to enhance their market position.   Why you have to check out today's podcast: Discover how pricing communicates a company's brand and market position. Explore the relationship between pricing, profitability, and business valuation. Learn about the importance of differentiation and how to create a competitive moat.   “Pricing is language. It communicates to the market what kind of brand you are.”  – Mike Blake   Topics Covered: 01:37 – The relationship between pricing and valuation.  02:30 – The importance of pricing in determining profitability and cash flow. 03:39 – Differentiation and competitive moats in pricing strategies.  04:53 – The shift from growth to profitability in business models. 08:36 – Signaling in pricing and its impact on investor perception.  11:17 – How to differentiate in a market dominated by larger players.  13:23 – The relevance of pricing strategies for SMBs, and how service-based companies offer consulting as value-ad. 17:04 – What Mike does. 19:36 – Why businesses that don't know their business model. 20:53 – Why value-based pricing is excruciatingly difficult. 25:53 – Mike's advice on pricing and negotiation.   Key Takeaways: “Pricing is the stem cell for all of that. [Cash flow, revenue, and profitability]” – Mike Blake “Companies that get pricing right are the most valuable.” – Mike Blake “If you're selling 100% of your deals you're probably not optimizing your revenue because you're selling too cheaply.” – Mike Blake “Understanding your unique data can create alternative revenue streams.” – Mike Blake   Connect with Mike Blake: LinkedIn: https://www.linkedin.com/in/unblakeable/ Email: mblake@highscoresstrategies.com   Connect with Mark Stiving: LinkedIn: https://www.linkedin.com/in/stiving/  Email: mark@impactpricing.com  

Tom welcomes back Chris Vermeulen, the founder of The Technical Traders, to discuss the highly volatile year of 2025 so far. He notes that volatility has been extreme across various asset classes, driven by factors like geopolitical tensions, AI advancements, and fears of an impending recession. Vermeulen emphasized that while day traders thrive in such environments due to significant intraday swings, swing traders face increased risks with massive price gaps. Long-term investors should prioritize capital preservation by moving to cash until market clarity emerges, as he believes a bear market has already begun. He warned against the "buy the dip" mentality, especially for those nearing retirement, cautioning that this approach could lead to significant losses in a prolonged bear market. Vermeulen points out key indicators of an impending financial reset, including economic data showing hiring declines and rising unemployment, as well as housing market corrections with inventories soaring. Gold was discussed as a safe haven asset, though Vermeulen cautioned about potential pullbacks. He suggested that gold miners could offer better opportunities once the market stabilizes. Seasonality plays a role in his analysis, noting that stock markets typically struggle post-May, aligning with his bearish outlook. Real estate was also addressed, with Vermeulen predicting price drops of 15-20% and warning about the broader economic impact as housing values decline. He highlighted the psychological effect on investors when their largest asset depreciates, potentially leading to panic selling across markets. The U.S. dollar's potential strength was discussed, with Vermeulen suggesting it could rally in a risk-off environment. Time Stamp References:0:00 - Introduction0:52 - Market Volatility & Trading4:58 - Markets in Topping Stage8:30 - Cliff Phase Indicators15:22 - Downside Targets Gold18:50 - Expectations for Miners?23:18 - Seasonality in 2025?26:00 - Silver Markets & Risk?28:57 - Bitcoin Decoupling31:45 - Real Estate & Nest Eggs34:30 - Google Search Trends42:08 - Dollar Thoughts48:49 - Mkt Resets & Wrap Up Guest Links:Twitter: https://twitter.com/TheTechTradersWebsite: https://www.thetechnicaltraders.com/ Chris Vermeulen is the Founder of Technical Traders Ltd. Chris has been involved in the markets since 1997. He is an internationally recognized technical analyst, trader, and author. Years of research, trading, and helping individual traders worldwide have taught him that many traders have great trading ideas, but they lack one thing. They struggle to execute trades systematically for consistent results. Chris helps educate traders, and his mission is to help his clients boost their trading performance while reducing market exposure and portfolio volatility. He has also been on the cover of AmalgaTrader Magazine and featured in Futures Magazine, Gold-Eagle, Safe Haven, The Street, Kitco, Financial Sense, Dick Davis Investment Digest, and dozens of other financial websites.

Yelena Shulyatyeva breaks down the Consumer Confidence report as it hits the lowest level since January of 2021. She discusses how low confidence can freeze buying and expects a “significant deceleration in economic growth this year.” She highlights that confidence is lower across the political, age, and other spectrums, pointing to broad-based fears. However, she thinks we can avoid recession with Fed rate cuts.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Detroit Pistons fans are DIFFERENT but in a very disturbing way. They showed their true colors on NATIONAL TV! Pistons fans, during a close and important playoff game, gave up on their team and left the arena. Signaling to everyone that they didn't believe anymore. KNICK FANS WOULDN'T EVER DO THIS! WE ARE BUILT DIFFERENTLY... Troy Mahabir breaks all of this down! SHOW CHAPTERS: 00:00 - Intro 00:47 - Pistons Fans Abandon Team On National TV! 02:45 - Pistons Fans Left Team After They Stopped Believing 04:39 - Detroit Limited Knick Fans Access To Watching Their Fans Leave? 06:39 - Knick Fans STAY No Matter What 08:49 - PUT SOME RESPECT ON NEW YORK! LISTEN NOW TO GET YOUR KNICKS FIX! Catch the latest special interviews, shorts, fan interactions, and more by following the show! Don't forget to turn on notifications so you don't miss another episode! Rather Watch the latest Knicks Recap episode? Catch us on YouTube here: https://www.youtube.com/@TheKnicksRecap Follow The Knicks Recap on all social media platforms! Twitter: https://twitter.com/TheKnicksRecap Instagram: https://www.instagram.com/TheKnicksRecap/ Reddit: https://www.reddit.com/u/TheKnicksRecap?utm_source=share&utm_medium=android_app&utm_name=androidcss&utm_term=1&utm_content=share_button Facebook: https://www.facebook.com/TheKnicksRecap/ Rather Listen to The Knicks Recap on a different platform? Catch us on ALL of your favorite streaming platforms: Apple Podcast: https://apple.co/3SKSl8o Spotify: https://spoti.fi/3QrEfr6 iHeart Radio: https://www.iheart.com/podcast/269-the-knicks-recap-a-new-yor-100895112/ Amazon Music: https://amzn.to/3QoZrOd Other Pod Channels: https://anchor.fm/the-knicks-recap Grab our MERCH featuring some of the graphics you've seen us create to take your Knicks fandom to the NEXT LEVEL: MAIN STORE: https://theknicksrecap.myspreadshop.com/ CashApp: $TheKnicksRecap Have a comment about the show, an interview, or a graphic idea? Reach out to The Knicks Recap on ALL SOCIAL MEDIA PLATFORMS!

In this episode, I sat down with Dr. Heather Sandison to talk about something that needs more attention Alzheimer's disease, and whether it can actually be reversed. She challenges the conventional belief that it's irreversible and dives into how environmental toxins, poor lifestyle habits, and hidden infections can drive cognitive decline. We broke it all down using the acronym "TNSSS-I" — Toxins, Nutrients, Stressors, Structure, Signaling, and Infections. Dr. Sandison shares powerful recommendations: an organic ketogenic diet, dual-task exercises, proper sleep, and detoxing from things like heavy metals, mold, and chemicals. We also touched on gut health, oral hygiene, blood sugar balance, and the role of APOE gene testing. If you've been impacted by Alzheimer's or want to protect your brain for the long run this episode gives you the practical tools and real hope. #alzheimer #wellness #antiaging Dr. Heather Sandison IG: @dr.heathersandison ==== Thank You To Our Sponsors! Calroy Head on over to at calroy.com/drg and Save over $50 when you purchase the Vascanox and Arterosil bundle at https://calroy.com/rachel. Cornbread Hemp Head to cornbreadhemp.com/DRG and use code DRG at checkout for a special discount—Cornbread Hemp: This is the good life. ==== Be sure to like and subscribe to #HealThySelf Hosted by Doctor Christian Gonzalez N.D. Follow Doctor G on Instagram @doctor.gonzalez https://www.instagram.com/doctor.gonzalez/ Sign up for our newsletter! https://drchristiangonzalez.com/newsletter/

If most voters are misinformed, is democracy legitimate? What sort of voting system should we have in its place? And should some votes count more than others?[00:00] Introduction to the Problems of Democracy[00:17] Brexit: A Case Study in Misinformed Voting[05:33] Voter Behavior: Social Benefits and Signaling[18:29] The Legitimacy of Democratic Systems[30:32] The Challenge of Political Incentives[33:02] The Abortion Debate and Judicial Power[36:41] Depoliticizing Social Life[43:10] Proposals for Enlightened Preference Voting[55:10] Global Voting and Democratic Legitimacy[58:28] Philosophical Reflections on Democratic TheoryCheck out FeedSpot's list of 90 best philosophy podcasts, where Brain in a Vat is ranked at 15, here: https://podcast.feedspot.com/philosophy_podcasts/

In an Oval Office meeting with the president of El Salvador, Donald Trump indicated that he won't bring a wrongly-deported man back from El Salvador, which would constitute a violation of a directive from the Supreme Court.As he was doubling-down on lawlessness and unconstitutionality, Trump also told the president of El Salvador that he "needs to build five more places" to hold American citizens, as Trump announced that "home-grown are next."Glenn takes on the question of what the federal judiciary may do in the coming days to address this attempt by Trump to destroy the constitutional construct of the American system of government.If you're interested in supporting our all-volunteer efforts, you can become a Team Justice patron at: / glennkirschner If you'd like to support Glenn and buy Team Justice and Justice Matters merchandise visit:https://shop.spreadshirt.com/glennkir...Check out Glenn's website at https://glennkirschner.com/Follow Glenn on:Threads: https://www.threads.net/glennkirschner2Facebook: https://www.facebook.com/glennkirschner2Instagram: https://www.instagram.com/glennkirsch...Bluesky: https://bsky.app/profile/glennkirschn...TikTok: https://www.tiktok.com/glennkirschner2See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In an Oval Office meeting with the president of El Salvador, Donald Trump indicated that he won't bring a wrongly-deported man back from El Salvador, which would constitute a violation of a directive from the Supreme Court.As he was doubling-down on lawlessness and unconstitutionality, Trump also told the president of El Salvador that he "needs to build five more places" to hold American citizens, as Trump announced that "home-grown are next."Glenn takes on the question of what the federal judiciary may do in the coming days to address this attempt by Trump to destroy the constitutional construct of the American system of government.If you're interested in supporting our all-volunteer efforts, you can become a Team Justice patron at: / glennkirschner If you'd like to support Glenn and buy Team Justice and Justice Matters merchandise visit:https://shop.spreadshirt.com/glennkir...Check out Glenn's website at https://glennkirschner.com/Follow Glenn on:Threads: https://www.threads.net/glennkirschner2Facebook: https://www.facebook.com/glennkirschner2Instagram: https://www.instagram.com/glennkirsch...Bluesky: https://bsky.app/profile/glennkirschn...TikTok: https://www.tiktok.com/glennkirschner2See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

- DMSO and Its Effectiveness in Cancer Treatment (0:00) - Health Ranger Store's Mission and Product Development (3:34) - Natural Healing and Regenerative Capabilities (6:20) - Therapeutic Peptides and DMSO (15:53) - Preserving Knowledge and Combating Depopulation (36:56) - Incubation Experiment with Chemtrail Sample (38:42) - Special Report on Forbidden Cures (49:38) - Gold and Silver as Safe Havens (1:10:10) - Four Chan Exposed as Mossad Intelligence Front (1:10:24) - Gold and Silver Investment Advice (1:14:00) - Gold Market Patterns and Investment Strategies (1:24:09) - Book Review: "The Big Drop" by James Rickards (1:26:30) - Economic Challenges and Trade Embargoes (1:33:45) - Interview with Chris Sullivan on Financial Markets (2:21:40) - Asset Allocation and Investment Strategies (2:21:57) - The Role of Digital Assets in Portfolio Management (2:30:18) - The Future of Crypto and Digital Assets (2:31:09) - The Great Taking and Financial Freedom (2:36:15) - Conclusion and Final Thoughts (2:36:34) - Introduction and Song Teaser (2:36:52) - Lyrics and Themes of the Song (2:37:25) - Economic and Political Impact (2:37:37) - Final Lyrics and Emphasis (2:38:24) For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews videos would not be possible without you, as always we remain passionately dedicated to our mission of educating people all over the world on the subject of natural healing remedies and personal liberty (food freedom, medical freedom, the freedom of speech, etc.). Together, we're helping create a better world, with more honest food labeling, reduced chemical contamination, the avoidance of toxic heavy metals and vastly increased scientific transparency. ▶️ Every dollar you spend at the Health Ranger Store goes toward helping us achieve important science and content goals for humanity: https://www.healthrangerstore.com/ ▶️ Sign Up For Our Newsletter: https://www.naturalnews.com/Readerregistration.html ▶️ Brighteon: https://www.brighteon.com/channels/hrreport ▶️ Join Our Social Network: https://brighteon.social/@HealthRanger ▶️ Check In Stock Products at: https://PrepWithMike.com

Pistons disrespected? Doug's new Summer Beer?

In this week's episode we'll learn about the role of interleukin-1 signaling in the bone marrow microenvironment in the development of myelodysplastic syndromes, the immune checkpoint regulator VISTA as a potential target for preventing graft-vs-host disease, and epcoritamab plus gemcitabine and oxaliplatin in transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma.Featured Articles:IL-1R1 and IL-18 signals regulate mesenchymal stromal cells in an aged murine model of myelodysplastic syndromesTargeting cell-surface VISTA expression on allospecific naïve T cells promotes toleranceEpcoritamab plus GemOx in transplant-ineligible relapsed/refractory DLBCL: results from the EPCORE NHL-2 trial

This week's show is sponsored by: EPIC-MRA Public Opinion Research MIRS News Fulton Fish Market This week on ""A Republic, If You Can Keep It" Republicans everywhere are reassessing after stumbling in a couple of Florida special elections that should have been slam dunks, and losing a State Supreme Court election in a Wisconsin landslide A day later by a stunningly trade war launched by the worst graduate in the history of the Wharton School of Economics. There was a Standing-Room-Only crowd as Democrats headlined a Town Hall in the heart of Macomb County, an event taking full aim at MIA Congressman John James. Last week, it was the most unqualified national security team ever assembled Signaling its stunningly consistent ineptness, with the revelation that at least one of them is conducting official business on Gmail. This week, it's RFK Jr. who, by advocating quack medicine while firing actual real scientists, accelerates a growing measles outbreak that's spreading from ground ZERO in Texas. Homeland Security ineptly condemns people to an indefinite stay in an El Salvador hell hole with no proof they've done anything wrong. And the U.S. Senate race has its first major candidate. We talk with state Senator Mallory McMorrow The first announced candidate for U.S. Senator is state Senator Mallory McMorrow. She exploded into the national spotlight in 2024 after an emotional response to very public personal attacks on her by Republican state Senator Lana Theis went viral. She is an ardent supporter of policies protecting reproductive rights, empowering local communities, and making Michigan a business- and family-friendly state. McMorrow is the Senate Majority Whip, serving her second term in the Michigan Senate. Prior to her election to the Senate she worked for more than a decade in product design, media and advertising with companies like Mazda, Mattel, Gawker Media, Hearst and other global brands. McMorrow hit the ground running during her first term in the Michigan Senate, winning policy changes such as ending Michigan's tampon tax, helping struggling businesses during the coronavirus pandemic, and protecting certain individuals (including domestic violence survivors) by creating an address confidentiality program. She earned her bachelor's degree in industrial design from the University of Notre Dame and resides in Royal Oak with her husband, Ray, their daughter, Noa, and their rescue dog, Detroit. At 38, she is the youngest person on the list of potential Senate candidates in either party. Ann Telnaes - antelnaes.com This episode is sponsored in part by =========================== EPIC ▪ MRA, a full service survey research firm with expertise in • Public Opinion Surveys • Market Research Studies • Live Telephone Surveys • On-Line and Automated Surveys • Focus Group Research • Bond Proposals - Millage Campaigns • Political Campaigns & Consulting • Ballot Proposals - Issue Advocacy Research • Community - Media Relations • Issue - Image Management • Database Development & List Management =========================== ===========================

Join Sara Evans in this exciting episode of Diving In Deep as she sits down with country music star, Lauren Alaina! In this heartfelt conversation, Sara and Lauren discuss the joys and surprises of pregnancy, with Lauren sharing her due date and the exciting news that she's having a girl! They dive into their experiences on Dancing With The Stars, the challenges of balancing motherhood with a busy career, and the importance of enjoying every moment of this incredible journey.Sara offers valuable advice from her own experiences as a mom, and the two bond over their shared backgrounds and love for music. They also reminisce about their early days in the industry, including her time on American Idol and the pressures of being a working mom in the spotlight.Don't miss this candid and uplifting episode filled with laughter, wisdom, and a few surprises along the way! If you enjoyed this episode, please like, subscribe, and share! Leave a comment below to let us know your thoughts!Listen to Unbroke: (https://ffm.to/seunbroke).About Lauren Alaina:Grand Ole Opry member and Big Loud Records powerhouse Lauren Alaina is unveiling a new musical chapter with the release of “Those Kind Of Women” and “Household,” out now. Signaling more new music on the horizon, the releases are the first taste of new music since her six-song 2023 EP Unlocked. Alaina has earned three chart-topping hits: RIAA Platinum-certified “Road Less Traveled,” Diamond “What Ifs” with her childhood friend Kane Brown, and 3X Platinum “ONE BEER” with labelmate HARDY + Devin Dawson. The Georgia-born force, who American Songwriter notes is “on a seemingly limitless upward trajectory,” has shared the stage with Alan Jackson, Blake Shelton, Carrie Underwood, Luke Bryan, Martina McBride, and more. This year, she joins the much-anticipated Rascal Flatts Life Is A Highway Tour. The vocalist has performed on some of the highest-profile stages in the world including PBS' A Capitol Fourth, Dancing with the Stars, American Idol, CBS' Beyond The Edge, ABC's The Bachelorette, TODAY, Good Morning America, The Ellen DeGeneres Show, The Kelly Clarkson Show, The Tonight Show, Jimmy Kimmel Live!, Macy's Thanksgiving Day Parade, ABC's CMA Fest specials, CMA and ACM Awards, Nickelodeon's All That, Dallas Cowboys Thanksgiving Day halftime performance, MLB's World Series national anthem performance, a performance at the White House for President Obama, and more.LET'S BE SOCIAL:Follow Lauren Alaina:Instagram – (@laurenalaina)Tiktok – (@laurenalaina)Twitter/X – (@Lauren_Alaina)Facebook – (https://www.facebook.com/LaurenAlaina)Website – https://www.laurenalainaofficial.comFollow Diving in Deep Podcast:Instagram –(@divingindeeppod)TikTok – (@divingindeeppod)Twitter – (@divingindeeppod)Facebook – (@divingindeeppod)Follow Sara Evans:Instagram – (@saraevansmusic)TikTok – (@saraevansmusic)Twitter – (@saraevansmusic)Facebook – (@saraevansmusic)Produced and Edited by: The Cast Collective (Nashville, TN)YouTube – (‪@TheCastCollective‬)Instagram – (@TheCastCollective)Twitter – (@TheCastCollective)Directed by: Erin DuganEdited By: Sean Dugan, Corey Williams, & Michaela Dolphhttps://www.thecastcollective.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Global macro commentator and gold advocate Mario Innecco joins us for an eye-opening conversation on the accelerating unraveling of our monetary system. From hyperinflation and default to the role of gold in a potential Bretton Woods 2.0, Mario shares unfiltered insights on what's really driving global markets. We discuss the collapse of fiat currency, central bank credibility, the real reason gold is surging, and how silver remains the “banker's kryptonite.” Whether by design or dysfunction, a new financial era is unfolding — and Mario breaks down what it means for investors navigating extreme macro volatility.#gold #hyperinflation #macroeconomics---------------------

Signaling that we're mindful, whether we're speaking, writing, posting, or messaging, is simple.There's no lying, denying, or blame. There's no harm done. We're remembering that what we say and do, matters. We're not gossiping, just sharing what's needed.And everything we say is kind.It's simple, but maybe not easy.  If it were, I feel like more of us would be mindful,whether we're talking to friends or planning a campaign. It's not easy, but it seems to me like a better standard of care, and a better Signal to the world, than the one we have now.

While everyone picks a side in the battle over the Signal text chat mess, Americans and conservatives are missing the bigger issue exposed. Trump has - once again - staffed his national security team with neocons.

Editors' Picks:Rich: Dan's post "Canada's Liberals Think Trump Has Saved Them"Jim: The Ideas SummitNoah: John Noonan's piece "America Needs Good Men Like Mike Waltz"MBD: Andrew Stuttaford's post "The Ozempic Economy: Adjusting to Longer Life Expectancy"Light Items:Rich: March Madness disappointmentJim: College tourNoah: End of the tractor sagaMBD: Guy Ritchie moviesSponsors:FastGrowingTreesOtherwise Objectionable, a new podcast series from CEIThis podcast was edited and produced by Sarah Colleen Schutte.

BUFFALO, NY - March 25, 2025 – A new #review was #published in Oncotarget, Volume 16, on March 13, 2025, titled “Signaling pathway dysregulation in breast cancer." In this review article, Dinara Ryspayeva and colleagues from Brown University provide a detailed look at how breast cancer cells change the way they communicate and grow—helping tumors survive, spread, and resist treatment. The review highlights how certain gene mutations and disrupted signaling pathways influence therapy response across different types of breast cancer. It also outlines current treatment strategies and clinical trials, offering insights that could improve care for patients with aggressive or hard-to-treat cancers. Breast cancer is the most common cancer in women and a major cause of cancer-related deaths worldwide. While many patients respond to treatment at first, some cancers return or stop responding. The review explores how signaling disruptions inside tumor cells are often behind these setbacks. The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These pathways help control cell growth, division, DNA repair, and survival. When altered by mutations or other changes, they can promote tumor progression and resistance to treatment. One of the most disrupted pathways is PI3K/Akt/mTOR. It plays a central role in cell growth, but in many breast cancers—especially hormone receptor-positive and HER2-positive types—it becomes overactive due to gene mutations, or the loss of a tumor-suppressing protein called PTEN. “Up to 25–40% of BC cases exhibit variations that hyperactivate the PI3K/Akt/mTOR pathway, underscoring its critical role in oncogenesis.” Another key pathway, RAS/RAF/MEK/ERK, can also promote tumor growth. Even without mutations, it may become active when primary pathways are blocked, particularly in HER2-positive and triple-negative breast cancers. The review also highlights several new and emerging treatments aimed at blocking down these signaling pathways. Some drugs are already approved, while others are in clinical trials. The authors suggest that combining different treatments may help stop multiple pathways at once, making it harder for cancer cells to adapt. Matching treatments to each tumor's unique genetic changes could also improve patient outcomes. This comprehensive review gives researchers and clinicians a clearer understanding of how breast cancer resists treatment and where future therapies should focus. A better understanding of these disrupted signaling systems could lead to more personalized and effective treatments for patients facing aggressive or recurring disease. DOI - https://doi.org/10.18632/oncotarget.28701 Correspondence to - Dinara Ryspayeva - dinara_ryspayeva@brown.edu Video short - https://www.youtube.com/watch?v=ppFVGwdztHI Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Ok first off, please disregard my insistence that the Spring Equinox is on Saturday...it's not! Somehow I got that in my head and onto my calendar. The astrological New Year and the Spring Equinox coincide on the same day! Thursday, March 20th. You can definitely still celebrate on Saturday though, I know I will be! Taking time to enjoy the sun, freshness of nature, and rumblings of new beginnings.  On this solo episode I wish everyone a Happy Spring Equinox & Astrological New Year and share some insights into these events and ways to recognize them. With the Spring Equinox marking a powerful and beautiful shift making way for new blessings , fresh energy, and divine alignment. And the beginning of Aries season and the new Astrological year brings a powerful cosmic gateway where manifestations speed up and new ventures begin to blossom. Nature's Whispers Oracle Cards: https://blueangelonline.com/shop/card-decks/oracle-cards/natures-whispers/* Women Waken Wednesdays will be held weekly on Wednesdays at 6pm PST starting in February! This is a virtual Women's group I'm holding for my beautiful listeners. I would love for you to join! Please contact me (IG or Email) for Zoom info!Donations To Women Waken To Support The Show Are Greatly Appreciated

On this episode of Wrestling Tonight, live from The Turnbuckle Tavern with Acefield Retro and Chad, Roman Reigns returns to Raw in dominant fashion, taking out Seth Rollins and CM Punk while Paul Heyman watches in fear. AEW Dynamite sees "Speedball" Mike Bailey make his debut, officially signing with the company and advancing in the International Title Eliminator Tournament, setting up a chance to challenge Kenny Omega at Dynasty. In WWE, NXT Roadblock delivers a milestone moment as Stephanie Vaquer becomes a double champion, defeating Giulia to unify the NXT Women's and North American Championships. Meanwhile, TNA Sacrifice ends in shocking fashion as Nic Nemeth turns on Matt Hardy after their team's hard-fought victory in the steel cage main event. Elsewhere in TNA, Moose retains the X-Division Championship in a brutal ladder match against Jeff Hardy, Masha Slamovich fends off WWE's Cora Jade to keep her Knockouts Title, and Tessa Blanchard positions herself as the next challenger. Over on SmackDown, The Street Profits reclaim WWE Tag Team gold, defeating DIY in front of a red-hot Barcelona crowd. Plus, cryptic vignettes tease Rey Fenix's WWE arrival, while a mysterious "4" fuels speculation about Malakai Black's future. We also break down AEW and Tony Khan's legal response to Ryan Nemeth's lawsuit, the final four in NJPW's New Japan Cup, and the latest major shifts in WWE's road to WrestleMania 41. Join us as we cover the biggest news and stories from WWE, AEW, TNA, NJPW, and beyond, only on The Turnbuckle Tavern!

We've all heard of virtue signaling -- when people make a big show – a sometimes cringe-inducing show – of their moral values, their progressivism, their empathy. The right-wing loves to mock it, and MAGA is taking things a step further...with vice signaling. Instead of working to show people how good they are, MAGA decides to show people just how awful they can be. Is this working? Tune in for Don's take! Learn more about your ad choices. Visit megaphone.fm/adchoices

The Legislature is considering bills that would lift restrictions on how Texas' maternal mortality committee can investigate maternal deaths, including by reviewing abortion-related deaths.Looking for a Tesla? Or trying to sell one? How politics appears to be reshaping the market for the Texas-based company long considered the leader in the electric vehicle space.Also: Seismic activity […] The post What are current struggles signaling for Texas-based Tesla? appeared first on KUT & KUTX Studios -- Podcasts.

Are the Bears' offseason moves signaling that they're going for it? full 859 Wed, 12 Mar 2025 16:02:46 +0000 WhDpCj8UPAGK9tU0vO9XHPA7HPniMqIx nfl,chicago bears,sports Bernstein & Harris Show nfl,chicago bears,sports Are the Bears' offseason moves signaling that they're going for it? Dan Bernstein and Marshall Harris bring you fun, smart and compelling Chicago sports talk with great listener interaction. The show features discussion of the Bears, Blackhawks, Bulls, Cubs and White Sox as well as the biggest sports headlines beyond Chicago. Leila Rahimi joins the show as a co-host on Wednesdays. Recurring guests include Bears linebacker T.J. Edwards, Pro Football Talk founder Mike Florio, Cubs outfielder Ian Happ and Cubs president of baseball operations Jed Hoyer. Catch the show live Monday through Friday (10 a.m.- 2 p.m. CT) on 670 The Score, the exclusive audio home of the Cubs and the Bulls, or on the Audacy app. © 2024 Audacy, Inc. Sports False https://player.amperwavep

Emilia and Rori chat with Dr. Joann Trejo, a daughter of Mexican migrant farm workers who blossomed into a respected pharmacology professor at UC San Diego. Dr. Trejo shares how thinking beyond the lab helped her reach her goals and grow in biomedical research. EPISODE CHAPERS:02:52 Dr. Trejo's Early Life and Family Background06:34 Educational Journey and Early Influences10:26 College and Early Research Experiences19:43 Pursuing a Faculty Position23:07 Balancing Academia and Mentorship24:41 Facing Bias and Discrimination25:43 Why some scientists should get an MBA35:15 Reflections and AdviceCREDITS: This episode is produced and edited by Maribel Quezada Smith. Sound Engineering by Keagan Stromberg. Production Coordinator, Marissa Alcantar. The hosts of Science Wise are Emilia Huerta-Sanchez and Rori Rohlfs. Special thanks to Dr. Joann Trejo. This is a Diferente Creative production.

Rebuke worry if it tries to pay you a visit in this season. It doesn't look like what it looks like. You're not in the old, you're in the new. God has established many of His people in a phase of life they've never experienced before. Things have shifted for you, forever. God can see what we can't and although there are things you want to see now and do now, the land isn't fully dry. But I have good news for you! God is signaling you're about to leave the ark. It won't be long until you experience fruitfulness and His divine multiplication in your life. God never heals and transforms His people and then not allow them to fulfill their destiny and receive what He promised them. Relax… God has not forgotten about you, He's just gone ahead of you to prepare the way. Press play to hear more! Mediated scriptures Genesis 6-9. This year we are praying more people would hear such messages, to be stirred to read God's word to live the life He always destined them to live, including having the right spouse and marriage He desired for them to have. If you enjoy this series, you don't want to miss our live session this year, “ Kingdom Relationships 2.0.” We'd love to meet you and exhort you in person. Subscribe to our site for updates!

Moran Cerf is a neuroscientist and professor at Northwestern University, specializing in decision-making and consciousness. His research blends neuroscience, psychology, and AI to explore how humans make choices. A former hacker, he also studies the intersection of brain science and technology. Cerf is a sought-after speaker at events like TED and the World Economic Forum. His work has gained recognition in both academia and popular science.In our conversation we discuss:(00:00) - Introductions(0:40) - Emotional regulation(5:50) - Having a second person that listens(8:37) - Chasing the story in your brain(10:17) - Exposures(12:35) - Embodied cognition(17:35) - Smell or odor(25:29) - Purpose of tears(29:01) - Being in a neutral place(31:59) - Major histocompatibility complex(33:29) - Magic pheromones(38:32) - Signaling emotions(42:18) - Persuasion(52:59) - Negotiation(1:00:26) - Being likableLearn more about Moran CerfOfficial Website: https://www.morancerf.com/Linkedin: https://www.linkedin.com/in/morancerfInstagram: https://www.instagram.com/morancerfWatch full episodes on: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@seankim⁠⁠⁠⁠Connect on IG: ⁠⁠⁠https://instagram.com/heyseankim

Mark Vitner and John Lonski discuss the U.S. labor market after the latest weekly Jobless Claims. “There's a very narrow set of industries that are adding jobs,” Mark notes, and thinks we could start to see cracks. John covers layoffs in the public and private sectors. Mark thinks that there will be another two rate cuts this year, while John thinks the Fed could cut in June if the economy continues to slow down.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Watch the video version of this podcast episode.https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-160-with-dr.-remi-janicot---------------------------------Become a #DrGPCR Ecosystem Member---------------------------------Imagine a world in which the vast majority of us are healthy.The #DrGPCR Ecosystem is all about dynamic interactions between us working towards exploiting the druggability of # GPCRs. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.---------------------------------To build our #GPCR Ecosystem, we created various enabling outlets. Individuals OrganizationsAre you a #GPCR professional? ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Subscribe to #DrGPCR Monthly Newsletter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Listen and subscribe to #DrGPCR Podcasts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Listen and watch GPCR-focused scientific talks at #VirtualCafe⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.

John Kosar returns with the Asbury 6, saying the “lights are green” since Feb. 5. He charts the S&P 500, forecasting expansion upwards after recent consolidation. He discusses the potential of volatility flipping Asbury signals to red.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Amazon warned the start of 2025 was rough, and boy was it. Government data on consumer spending as well goods production came in exactly that way. And while extreme winter weather played a role in each one, it was clearly the opposite of what everyone says. Eurodollar University's Money & Macro AnalysisNYT Amazon Says Profits Rose 88% but Cautions Growth May Slowhttps://www.nytimes.com/2025/02/06/technology/amazon-earnings-profits.htmlCNN US retail spending plunged last month, falling for the first time since Augusthttps://www.cnn.com/2025/02/14/economy/us-retail-spending-january/index.htmlhttps://www.eurodollar.universityTwitter: https://twitter.com/JeffSnider_EDU

The federal agency that enforces workplace anti-discrimination laws now wants to toss out its own lawsuit. AP correspondent Donna Warder reports.

Lights, camera, AUCTION! We're in the next-to-last part of Crooked Kingdom and all the plans are finally coming together! We have news AND a message from a new listener! Kaz wants to earn respect, THEN leadership Apparently you can just… sell your own contract?  Signaling the end of Matthias Returning Ravkans Fun Segment: Two Baghras and an ApparatQuestion of the week: When Jesper accidentally kissed Kuwei instead of Wylan, was it understandable or unforgivable? Next time: Part 6.1!CONTACT US: You can listen to us everywhere pods are cast!  Youtube we are Into the Fold Podcast You can find us on Instagram: @Intothefoldpod You can email us: intothefoldpod@gmail.com Check out out Etsy shop: Grisha Trading Post  Leave us a rating and review on apple podcasts or spotify and we will read it on the show!  TELL PEOPLE YOU KNOW TO LISTEN TO THE SHOW!Until next time, no mourners! No funerals!

Guest: Fahad Mughal, Senior Cyber Solutions Architect - SecurityOn LinkedIn | https://www.linkedin.com/in/fahadmughal/____________________________Host: Sean Martin, Co-Founder at ITSPmagazine [@ITSPmagazine] and Host of Redefining CyberSecurity Podcast [@RedefiningCyber]On ITSPmagazine | https://www.itspmagazine.com/sean-martinView This Show's Sponsors___________________________Episode NotesModern railway systems are increasingly digital, integrating operational technology (OT) to enhance efficiency, reliability, and safety. However, as railways adopt automated and interconnected systems, they also become more vulnerable to cyber threats. In this episode of Redefining Cybersecurity on ITSP Magazine, host Sean Martin speaks with Fahad Ali Mughal, a cybersecurity professional with extensive experience in OT security architecture, about the challenges and priorities of securing railway infrastructure.The Growing Role of Cybersecurity in RailwaysRailway systems have evolved from steam-powered locomotives to autonomous, driverless trains that rely on sophisticated digital controls. OT now plays a crucial role in managing train operations, signaling, interlocking, and trackside equipment. These advancements improve efficiency but also expose railway networks to cyber threats that can disrupt service, compromise safety, and even impact national security. Unlike traditional IT environments, where the focus is on confidentiality, integrity, and availability (CIA), OT in railways prioritizes reliability, availability, and public safety. Ensuring the safe movement of trains requires a cybersecurity strategy tailored to the unique needs of railway infrastructure.Critical OT Systems in RailwaysMughal highlights key OT components in railways that require cybersecurity protection:• Signaling Systems: These function like traffic lights for trains, ensuring safe distances between locomotives. Modern communication-based train control (CBTC) and European Rail Traffic Management Systems (ERTMS) are vulnerable to cyber intrusions.• Interlocking Systems: These systems prevent conflicting train movements, ensuring safe operations. As they become digitized, cyber risks increase.• Onboard OT Systems: Automatic Train Control (ATC) regulates speed and ensures compliance with signaling instructions. A cyberattack could manipulate these controls.• SCADA Systems: Supervisory Control and Data Acquisition (SCADA) systems oversee infrastructure operations. Any compromise here can impact an entire railway network.• Safety-Critical Systems: Fail-safe mechanisms like automatic braking and failover controls are vital in preventing catastrophic accidents.The increasing digitization and interconnection of these systems expand the attack surface, making cybersecurity a top priority for railway operators.Real-World Cyber Threats in RailwaysMughal discusses several significant cyber incidents that highlight vulnerabilities in railway cybersecurity:• 2023 Poland Attack: Nation-state actors exploited vulnerabilities in railway radio communication systems to send unauthorized emergency stop commands, halting trains across the country. The attack exposed weaknesses in authentication and encryption within OT communication protocols.• 2021 Iran Railway Incident: Hackers breached Iran's railway scheduling and digital message board systems, displaying fake messages and causing widespread confusion. While safety-critical OT systems remained unaffected, the attack disrupted operations and damaged public trust.• 2016 San Francisco Muni Ransomware Attack: A ransomware attack crippled the fare and scheduling system, leading to free rides for passengers and operational delays. Though IT systems were the primary target, the impact on OT operations was evident.These incidents underscore the urgent need for stronger authentication, encryption, and IT-OT segmentation to protect railway infrastructure.Cybersecurity Standards and Best Practices for Railways (links to resources below)To build resilient railway cybersecurity, Mughal emphasizes the importance of international standards:• IEC 62443: A globally recognized framework for securing industrial control systems, widely applied to OT environments, including railways. It introduces concepts such as network segmentation, risk assessment, and security levels.• TS 50701: A European standard specifically designed for railway cybersecurity, expanding on IEC 62443 with guidance for securing signaling, interlocking, and control systems.• EN 50126 (RAMS Standard): A safety-focused standard that integrates reliability, availability, maintainability, and safety (RAMS) into railway operations.Adopting these standards helps railway operators establish secure-by-design architectures that mitigate cyber risks.Looking Ahead: Strengthening Railway CybersecurityAs railway systems become more automated and interconnected with smart cities, vehicle transportation, and supply chain networks, cyber threats will continue to grow. Mughal stresses the need for industry collaboration between railway engineers and cybersecurity professionals to ensure that security is integrated into every stage of railway system design.He also emphasizes the importance of real-time OT threat monitoring, anomaly detection, and Security Operations Centers (SOCs) that understand railway-specific cyber risks. The industry must stay ahead of adversaries by adopting proactive security measures before a large-scale cyber incident disrupts critical transportation networks.The conversation makes it clear: cybersecurity is now a fundamental part of railway safety and reliability. As Mughal warns, it's not a question of if railway cyber incidents will happen, but when.To hear the full discussion, including insights into OT vulnerabilities, real-world case studies, and cybersecurity best practices, listen to this episode of Redefining Cybersecurity on ITSP Magazine.___________________________SponsorsImperva: https://itspm.ag/imperva277117988LevelBlue: https://itspm.ag/attcybersecurity-3jdk3ThreatLocker: https://itspm.ag/threatlocker-r974___________________________Watch this and other videos on ITSPmagazine's YouTube ChannelRedefining CyberSecurity Podcast with Sean Martin, CISSP playlist:

How is market signaling tied to economic growth, and what will the introduction of AI do to the wave of economic development in the US and abroad? Will other surging economies surpass the United States as dynamics continue to change?Michael Spence is a senior fellow at the Hoover Institute at Stanford University, also the author of a number of books, including The Next Convergence: The Future of Economic Growth in a Multispeed World and most recently, Permacrisis: A Plan to Fix a Fractured World.Greg and Michael discuss Michael's ideas on economic growth and signaling, exploring the early days of applied micro theory with key figures like Ken Arrow and Tom Schelling. They also cover the evolution of global economic policy, particularly the challenges and opportunities in an increasingly fragmented world. Michael shares insights from his books and emphasizes the importance of cognitive diversity in understanding and addressing global socio-economic issues.*unSILOed Podcast is produced by University FM.*Show Links:Recommended Resources:Kenneth ArrowRichard ZeckhauserThomas SchellingThe Market for LemonsPooling EquilibriumJohn Maynard SmithErving GoffmanEdward LazearWashington ConsensusReport: EU competitiveness: Looking aheadGuest Profile:Professional Profile at the Hoover InstitutionProfile for the Council on Foreign RelationsNobel Prize ProfileWikipedia PageHis Work:Permacrisis: A Plan to Fix a Fractured WorldThe Next Convergence: The Future of Economic Growth in a Multispeed WorldEpisode Quotes:The scarcity of time as a signal18:56: It turns out time is an incredibly important signal. In just an ordinary interaction, if somebody's willing to spend time with you, we always take this for granted because it's part of life, right? If they won't spend time with you, that sends a different signal. I mean, in the internet era, I think most people understand that the scarcest commodity is attention, not money, not other things. And so, the battle for people's attention, or time, or whatever you want to, these are slightly different, but it's pretty important. So, it's all there, but it did have origins well before the signaling and screening work.Signaling model has to be visible11:11: The core of the signaling model is that it has to be visible. It has to cost something; otherwise, everybody would do it. And the costs have to be negatively correlated with the quality; otherwise, it won't survive in equilibrium.Navigating crises, inequality, and global interdependence49:19: The way I approach that is try to look at the big challenges: maintaining some reasonable level of global sort of interdependence with the benefits that it brings without getting into big trouble, dealing with the various dimensions of the sustainability agenda, and dealing with sort of stunningly high levels of inequality, especially in wealth. Thomas Piketty's right; there's long cycles in these things, and maybe you just have to live through them. But, the last thing I did is look at the St. Louis Fed, which publishes pretty detailed data on American household net worth, assets, liabilities, and net worth. The top 10 percent has two-thirds of the net worth. The bottom 50 percent has 3%. Yeah. Sort of wonder, you know, can you really run a society that looks like that indefinitely, or if not, what's going to break and cause it to change?

How old are you? A better question might be: how old do you feel? While your birthday says one thing, your biological age—the health of your cells—might tell a very different story. And here's the best part: unlike your chronological age, your biological age can go down. But how? For years, fasting has been celebrated as a key to longevity. Yet the challenge of skipping meals is enough to make most of us shy away. What if you could trick your body into reaping the rewards of fasting—without starving yourself?  This week, we're joined by Dr. Valter Longo, Director of the Longevity Institute at USC and one of TIME's 50 most influential people in healthcare. Valter's groundbreaking research on ageing and his FMD program have transformed how we think about health and longevity. Joining him is Tim Spector, ZOE's co-founder and one of the world's top 100 most-cited scientists.

We've all heard about Ozempic. But there are the GLP-1s we colloquially call “Ozempic” (see also: Wegovy, Mounjaro, Zepbound) and then there's the cultural role of Ozempic. Given the price of these drugs, barriers to access, and class implications of weight stigma, this topic presents a unique opening to talk about inequality in health outcomes and the profitable business of individualizing social problems. In part one of this rare two-part series, we're covering:  The wage penalties associated with (and relationship between) weight and women, and the parallels between the American attitudes about thinness and wealth The Danish pharma company that put Europe's entire economy on its back A conversation with a 12-year veteran of drug and device advocacy who said some of the surrounding issues represent, and I quote, “everything wrong with health policy in our country,” especially given the shortages, costs, and online pharmacies springing up to bridge that gap with non-FDA-approved solutions Let's take a peek at the inside the business of weight loss drugs, and join us here next week for part two. Transcripts, show notes, production credits, and more can be found at: https://moneywithkatie.com/weight-loss-drugs. Money with Katie's mission is to be the intersection where the economic, cultural, and political meet the tactical, practical, personal finance education everyone needs. Learn more about your ad choices. Visit megaphone.fm/adchoices

Host Katherine Mallett, MD Guest interviewee Jacob Sorenson, MD, discussing his training room article, “The Power of Preference Signaling: A Monumental Shift in the Orthopaedic Surgery Application Process” from the January 15, 2025 issue Articles summarized from the January 15, 2025 issue Research article “The Effect of Cemented Implants Placed During Initial TKA on Surgical Time and Expenses in Revision TKA” Research article “The Influence of Previous Joint Arthroplasty on Fulfillment of Patients' Expectations of Subsequent Lumbar Surgery” Follow this link to download these and other articles from the January 1, 2025 issue of JAAOS and the January 15, 2025 issue of JAAOS The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

In this episode, we sit down with Juraj Kocar, the CEO of Wyse Earth, to discuss his mission to provide natural support through adaptogenic honey. He dives into the world of adaptogens, particularly focusing on the powerful health benefits of adaptogenic mushrooms like reishi, cordyceps and lions mane. We explore the science behind these mushrooms, their ability to modulate the immune system, fight inflammation, and promote overall wellness. If you're curious about the intersection of nature and wellness, this episode offers valuable information on how this adaptogenic mushroom honey elixir is revolutionizing the way we think about vibrant health and resilience.Juraj Kocar, a 3x founder, is passionate about building and growing projects with meaning that impact the health & wellness of people worldwide. Currently, he's the CEO of Wyse Earth and on a mission to provide natural support via adaptogenic honey for the No. 1 health issue in the U.S.: chronic inflammation. As the CEO of Attune Health and Somavedic Technologies, he leads the strategic business and relationship development of two innovative ventures. Building on these experiences, he launched Wyse Earth to address chronic inflammation, the No. 1 health issue in the U.S., through powerful natural solutions. Wyse Earth focuses on adaptogenic products that harness high-potency adaptogenic extracts, combined with honey for enhanced taste and bioavailability. Guided by his knowledge of adaptogens—substances that increase the body's resilience to stress and restore balance—Wyse Earth's products feature adaptogenic mushrooms, some of the most effective natural agents against inflammation, to support holistic health and wellness.SHOW NOTES:0:40: Welcome to the show!1:15 About Wyse Earth3:47 Juraj Kocar's Bio4:13 Welcome him to the podcast!6:06 What are adaptogenic mushrooms?10:07 Signaling the immune system to work better12:02 Adaptogenic vs Psychedelic13:27 Formulation and dosage of Wyse Earth17:47 Quality & Sourcing of clean mushrooms19:00 Fruiting bodies vs Mycelium21:51 Raw vs heated honey22:31 Benefits of Reishi24:02 Benefits of Cordyceps25:55 *MAGNESIUM BREAKTHROUGH*27:52 Benefits of Lion Mane30:18 The story behind Wyse Earth31:08 *CAROL BIKE*33:14 The inspiration behind Wyse Earth38:19 Ketogenic diet, cancer, diabetes & honey46:10 Different blends of Wyse Earth40:55 Upcoming blend: Slim53:17 His finale piece of advice55:17 Where to find him57:13 Thanks for tuning in!RESOURCES:Wyse Earth - Discount code: BIOHACKERBABESIG: Wyse_EarthIG: Juraj.KocarBiOptimizer's Magnesium Breakthrough - code: biohackerbabes10Carol Bike - code: BIOHACKERBABES for $250 offSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Crypto News: Bitcoin and Altcoins such as XRP, Cardano, SUI and more are starting to move upwards. Is this the start of the next price move upwards our of the pullback and consolidation zone?Show Sponsor -

Update on T-bills. Last week's wild auctions repeated this week, only with flipped maturities. Other related data confirm the sharp demand as well as dealer participation in it. We discuss the implications plus dig into the reason why collateral is so important to begin with, and also why we don't know nearly enough about what's going on. Eurodollar University's Money & Macro AnalysisWEBINAR REPLAY, w/SPECIAL GUEST JIM RICKARDShttps://event.webinarjam.com/go/replay/26/7y53nc7mb44azzawFRBNY Primary Dealer Statisticshttps://www.newyorkfed.org/markets/counterparties/primary-dealers-statisticsIOSCO Securities Lending Transactions: Market Development and Implicationshttps://www.iosco.org/library/pubdocs/pdf/IOSCOPD96.pdfOFR Why Is So Much Repo Not Centrally Cleared?https://www.financialresearch.gov/briefs/files/OFRBrief_23-01_Why-Is-So-Much-Repo-Not-Centrally-Cleared.pdfhttps://www.eurodollar.universityTwitter: https://twitter.com/JeffSnider_EDU

Retired NYPD inspector Paul Mauro joins Fox Across America With Jimmy Failla to explain the actual motivations behind President Biden's decision to pardon his son Hunter. Jimmy talks about how President-elect Trump is showing other countries around the globe that the U.S. is done being taken advantage of once he reassumes office in January. PLUS, co-host of “The Big Money Show” on Fox Business Brian Brenberg stops by to discuss why owning a home has become so difficult for millennials. [00:00:00] President-elect Trump sends a message to Hamas [00:37:20] Update on the Daniel Penny trial [00:55:40] Paul Mauro [01:13:53] How the Left's policies have hurt the U.S. [01:32:20] Brian Brenberg Learn more about your ad choices. Visit megaphone.fm/adchoices