Podcasts about signaling

Varying physical quantity that conveys information

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Latest podcast episodes about signaling

Financial Sense(R) Newshour
Is Retail Signaling a Market Crash? Mish Schneider Weighs In

Financial Sense(R) Newshour

Play Episode Listen Later Mar 14, 2026 36:30


Mar 13, 2026 – Mish Schneider at Market Gauge tells Financial Sense Newshour why she's raised cash while holding to a core position of commodities given the current trends in the market. Mish says that one of the most important sectors she follows...

The
Peptides, Fasting, and the Future of Longevity w/ Miguel & Carlos

The "What is Money?" Show

Play Episode Listen Later Mar 13, 2026 174:50


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Sea Control
Sea Control 598: Continental Powers and Naval Development

Sea Control

Play Episode Listen Later Mar 12, 2026 38:42


Links No paywall “Erasing the American Global Military Footprint Won't Make a Better World,” in Newsweek “Five Recommendations for Left-of-Boom Security Assistance to Taiwan,”in War on the Rocks “The Taiwan Question: Cross-Strait Relations and US Policy Past, Present, and Future,” virtual lecture for the Naval War College Foundation Paywalled “Muddied Waters: Freedom-of-Navigation Operations as Signals in the South China Sea,” in The British Journal of Politics and International Relations “New Imagined Geographies into Old Geobodies: Problems and Prospects for China and Taiwan in the South China Sea,” in Territory, Politics, Governance “Security in the Asia-Pacific and Signaling at Sea,” in International Relations of the Asia-Pacific

The Low Carb Athlete Podcast
Middle Age Muscle Signaling Shift — Leucine Threshold, Protein Distribution & Building Your Strongest FutureYou

The Low Carb Athlete Podcast

Play Episode Listen Later Mar 8, 2026 43:27


ToddCast Podcast
Is White House Signaling Softer Stance on Illegals?

ToddCast Podcast

Play Episode Listen Later Mar 6, 2026 112:33 Transcription Available


Sen. Markwayne Mullin, the president’s pick to be the next secretary of Homeland Security, says that considerations should be made for the children of illegals. Do you agree with that assessment? Should DHS only focus on the most hardened illegal alien criminals?See omnystudio.com/listener for privacy information.

B2B Marketers on a Mission
Ep. 210: Why Authority Now Matters More Than Visibility in B2B Content

B2B Marketers on a Mission

Play Episode Listen Later Mar 5, 2026 37:43 Transcription Available


Why Authority Now Matters More Than Visibility in B2B Content With AI making it easier than ever to create content, B2B buyers are drowning in a sea of digital noise. To rise about the generic, “AI-slop”, the new differentiator is no longer only visibility, but the ability to convey authentic brand authority. More often than not, it is the perceived credibility and depth of a brand's messaging that decides whether B2B companies are shortlisted or ignored by well-informed decision makers. So how can B2B companies build a solid thought leadership strategy that creates trust and sets them apart from competitors? That's why we're talking to Jamie Thomson (Copywriter and Founder, Brand New Copy), who shares his expertise and insights on why authority now matters more than visibility in B2B content. During our conversation, Jamie emphasized that true authority is built through consistent communication and unique insights rather than controversial stances. He criticized the over-reliance on AI for content ideation and encouraged businesses to focus on their unique selling points and authentic company culture. Jamie stressed the need for documented brand positioning and strategic messaging to build credibility across all channels. He also underscored the value of thought leadership and social proof in signalling authority, and suggested that businesses should invest in understanding and documenting their positioning for success in the long run. https://youtu.be/k4H-0M5ZL7g Topics discussed in episode: [02:47] The end of easy visibility: Why AI overviews and shifting algorithms mean you can no longer control traffic through traditional SEO alone. [07:09] Redefining authority: Authority isn’t about being controversial or loud; it is built through the consistency of your message and brand voice. [13:31] Chasing the right metrics: Why “visibility for visibility’s sake” is a vanity metric, and how to tie your content strategy to actual business outcomes.  [19:39] The credibility anchor: How being consistent with your own unique data and statistics keeps your brand from becoming an “average” forgettable competitor.  [21:42] Messaging for committees: A simple 3-step formula to establish messaging that resonates with human decision-makers, even in complex B2B environments. [27:35] Signaling authority: Practical ways to use “social proof” and unique data to back up your claims in proposals and on your website.  [31:18] Future-proofing your brand: Why documenting your positioning today is the only way to maintain longevity over the next decade. Companies and links mentioned: Jamie Thomson on LinkedIn  Brand New Copy  Copywriting Course at Brand New Copy Transcript Jamie Thomson, Christian Klepp Jamie Thomson  00:00 You know, maybe it’s a personality thing, but like, I’m not particularly controversial in my marketing and I do think people take that stance, like we are the young upstarts, or we are going to make a point of disagreeing with this company so that we can get engagement, whether they believe what their sort of stance are taking or not. It’s, it’s almost that sort of strategy of, there’s no such thing as bad press, and it’s probably effective short term and that’s why people are doing it. But if you’re looking to build a sort of a future proof business, comes back to that idea of authority being a bit consistency, unless your whole strategy is to be controversial, it’s more of a short term gain tactic. I think strategy is even a strong word. I think it’s a tactic. Christian Klepp  00:48 With AI making it easier than ever to create content, B2B, buyers are drowning in a sea of digital noise. To rise above this noise, the new differentiator needs to be delivered through authority. More often than not, it’s the credibility of a brand’s messaging that decides whether they’re shortlisted or ignored. So how can B2B companies leverage this and build their credibility? Welcome to this episode of the B2B Marketers on the Mission podcast, and I’m your host, Christian Klepp, today, I’ll be talking to Jamie Thomson, who will be answering this question. He’s an award winning copywriter and founder of Brand New Copy who puts strategy at the center of the process to define what the copy should achieve. Tune in to find out more about what this B2B Marketers Mission is. Okay, and off we go. Mr. Jamie Thomson, welcome to the show, sir. Jamie Thomson  01:34 Hi, Christian. It’s good to speak to you again. Thanks for having me on. Christian Klepp  01:38 Great to have you here. I mean, we had such a dynamite conversation. Like, a few weeks ago, I should have, like, hit record on that conversation too, right? Like, yeah, absolutely, Jamie, I’m really looking forward to this conversation because, you know, one of the things that you’re going to talk about today is, like, near and dear to me as somebody that also dabbles in the world of copywriting for B2B, but um, so here we go, right? So Jamie, you’re on a mission. I’m going to say, to help B2B companies to define their messaging, strengthen their positioning and communicate with authority across every channel. So this is really serious stuff here. Okay, so for this conversation, I’d like to focus on the topic of why authority now matters more than visibility and B2B, right? So I’d like to kick off the conversation with two questions, right? And I’m happy to repeat them. First question is, why do you believe authority is important, especially in an age where AI is creeping into B2B content and everything else. And where do you see a lot of B2B brands falling flat with the authority piece? Jamie Thomson  02:47 Yeah, so I think, I think authority is more important now than ever has been because, like you said, because there’s a lot of like, LLMs (Large Language Models) now kind of doing a lot of the marketing work that was maybe, you know, handled by humans before. I think that you know, sort of the sort of background context to this is that, you know, as Marketers, we don’t have as much control over the visibility of our content as we used to like Google, for example. You now have AI (Artificial Intelligence) overviews. So even if you get to like position one in Google, you’re still at the bottom of the page. Because you’ve got your AI overviews, you have sponsored results, and then there’s the organic listings underneath. And even if you’re position one, you’re still at the bottom of the page earlier. As a result, website traffic has reduced, and people aren’t getting the same kind of like traffic numbers that they used to on LinkedIn as well, like the way that the algorithms are sort of working nowadays. There doesn’t really seem to be any regular reason as to which posts perform well, it seems to be the sort of casual, off the cuff posts that seem to seem to get a lot of attention. There is a genuinely useful, you know, thought leadership stuff has kind of been pushed to the back burner a little bit. So I think authority is important because we don’t have as much control over visibility as we used to, and I think it’s the genuinely useful content that is the stuff that’s going to get shared, whether or not the algorithms are going to push that. So if you have produced a piece of content that has, like, really unique data points that is genuinely useful to other businesses, and it’s get shared online. It’s going to get shared internally between companies, and it’ll get linked to as well. And again, like to answer your second question, and where do a lot of sort of B2B brands like sort of miss the mark? I think. I think the main thing is that they’re the content that they’re producing isn’t genuinely useful. They are a lot of brands across industries that are kind of seeing the same thing as their competitors. And I don’t know for sure, but I have a sort of inclination that is down to LLMs, because they’re kind of relying on like chatGPT for their ideas. They’re asking chatGPT to give them ideas for content. And, you know, chatGPT, it can give you the output, but it can’t give you the input. You know, it’s a technology of averages. So if you’re looking to LLMs for ideation, it’s going to give you the average of what everyone else in industry is saying. So it’s important that your businesses are really doubling down on their ideation and things that make them unique as a company, like their unique selling points, their value propositions, their company culture. You know, the people behind the business, that’s kind of what makes a company’s culture and chatGPT, llms, they don’t really have any first hand experience of that, and it’s such a nuanced thing that you’re never going to get like effective results if you’re asking LLMs for the ideas in the first place. If you’re using it for execution, to help guide style and tone a little bit, then that’s fair enough. But, yeah, it’s important that brands are sort of really doubling down on the ideation. You know, that’s that, I think, just genuine, unique insights that people are actually going to be interested in reading. Christian Klepp  06:38 Absolutely, I had a couple of follow up questions for you there. I mean, this is great stuff. This might sound like overly, like simplified. I mean, for lack of a better description, but like, just, let’s clear the air here a little bit. Define, from your experience and your own interpretation, define authority, because that also gets thrown around very loosely, I feel almost as, almost as much as the term you’ve got to add value. I mean, like, you know, what does that actually mean, right? Jamie Thomson  07:09 Yeah, yeah. So to me, authority is about a brand communicating their messages in a consistent way, whether that is the actual content of the messages or the way that they actually communicate it, in terms of brand tone of voice. So authority, to me, is about consistency, more than it is about being emphatic or controversial or overly confident. It’s more about consistency and how they communicate their messages to their audience. Christian Klepp  07:44 You brought up something there, and I’m going to throw out another question, because I you find this a lot on LinkedIn, at least from my experience, that people put out a lot of pieces. I’m going to just dare to say under the guise of authority, but what it actually is like, just an extremely contrarian point of view. And it’s almost like, you know, I’ve got a I’ve got to just put my thoughts out there, because I want my voice to be heard. But it’s not necessarily authority. It’s just like disagreeing with the status quo. What’s your take on that? Jamie Thomson  08:15 Yeah, I mean, to me, that’s, that’s kind of it’s almost performance marketing. It’s just performing, if it’s like visibility for visibility’s sake, you know, maybe it’s a personality thing, but like, I am not particularly controversial in my marketing, and I do think people take that stance like we are the young upstarts, or we are going to make a point of disagreeing with this company so that we can get engagement. You know, whether they believe what their sort of stance are taking or not, it’s it’s almost that sort of strategy of, there’s no such thing as bad press, and it’s probably effective short term, and that’s why people are doing it. But you know, if you’re looking to build a sort of a future proof business, it comes back to that idea of authority, being about consistency, unless your whole strategy is to be controversial. It’s more of a short term gain tactic. I think strategy is even a strong word. I think it’s a tactic. It’s not really magic. Christian Klepp  09:19 Yeah, yeah, I love that. You said it was performance, performance marketing. You know, it almost feels like they’re, they’re, they’re playing the algorithm, or they’re trying to, like, just get more engagement. And it’s true, like, whether they actually believe what they’re saying or not, at least they’re getting more eyeballs on all look what this guy said, Yeah. Jamie Thomson  09:38 I mean, you see it in so many different ways. Like, a lot of the time, it’s with job postings as well, like, especially for for consulting season freelancers, you see, like you have a potential opening for a freelance position, you know, comment below if you know anyone that would be interested. Then again, I don’t know for sure, but I seems very performative to me. Has that company actually reached out to people directly about the job? Have they advertised on job sites, or are they just posting about it as a potential opportunity for the sake of engagement, knowing that people will be replying and tagging other people? And yeah, it’s that kind of a short term tactic. Christian Klepp  10:22 Exactly, exactly, before we go on to the next question, I have one final follow up for you on this topic, right? Like so where, where do you do you believe that sometimes things go awry with brands because a it’s about time and speed. They need to get something out quickly. They needed the day before yesterday. And hurry up and let’s, let’s get some, let’s get some volume out there. Let’s get plenty of content out there, right? So one, that’s one thing. The second thing is, do you feel that they missed the mark? Also? Because they, I’m just gonna say it, they just generally don’t understand who the target audience is. Jamie Thomson  11:03 Yeah, I think you’re writing both accounts there. I mean, you know yourself Christian, how long it takes to produce a good piece of content. It takes research. It’s not something that you can kind of write in half a day. So I do think that’s part of it. There’s that sort of pressure of always having to be seen. And so, yeah, I think, I think people are putting stuff out. A lot of businesses put stuff out either because it’s trending, because they see other people are doing it, or because they have, you know, they’ve asked an early lens for topic ideas as a technology of averages, it’s going to give you ideas that are already out there. So yeah, I think that’s definitely part of it. And then the second part, I think you’re totally bang on with that as well. I think a lot of people just don’t really understand what their positioning is in the industry. I say people, I’m talking about businesses, but at the end of the day, it’s still people that you’re talking to, like even though it’s B2B is business to business, the people making the decisions are still human beings, so your content needs to resonate with them. And I think people now have this kind of detector of when something is has been genuinely thought out. You know, thoughtful content is it’s kind of becoming few and far between because of like LLMs and because people can produce things quickly, and it’s kind of content for content sake. So yeah, I think people just don’t understand their positioning in industry and what their values are, and what stands they’re taking really, kind of just jumping from, you know, from one topic to the next, hoping that something is going to go viral, you know, which I guess they’re hoping will then lead to some sort of business outcome, ie, sales. But the stuff that makes the sales is the stuff that really, that had to be kind of properly thought out, in my opinion. Christian Klepp  13:06 Yes, oh yeah. Imagine that, wow, properly thought out. Absolutely, absolutely. I’m glad you brought that up, because that’s a great segue into the next question about key pitfalls, right? When we’re talking about like a brand building its credibility and authority. What are some of the key pitfalls that B2B Marketers and their companies need to look out for, and what should they be doing instead? Jamie Thomson  13:31 Yeah, I mean, I think that the key, one of the key pitfalls that I see as the whole visibility for visibility’s sake, you know, it’s, it’s kind of a vanity metric, in a way that so, like, you’ve made this piece of content and it’s been made 1000 times, or you’ve made the post and it’s been linked by 200 people, you know, and unless that is tied to a business outcome, it’s, it’s just visibility for visibility’s sake. And so one of the key pitfalls is, I think a lot of companies don’t tie their content strategy to their business outcomes enough. They’re kind of chasing engagement because it looks good in reports, so it’s good to stakeholders. But the reality is, unless that content has resulted in an inquiry or a product sale. You know, how successful has it really been? If it was just like a one off, let’s try this, unless it’s part of our strategy, but it’s a one off and it hasn’t really resulted in a sale or an inquiry, then can we deem it to be successful? And that’s up for the business to decide. But think that’s a common pitfall. And I think the second one for me is just what we said before about trends like I see a lot of because I work with businesses across a few different industries, mostly finance, technology, energy and sort of sustainability, and I see a lot of businesses jumping on trends in terms of the things that they’re talking about, like their messaging. It’s almost like one person has started talking about it, and they’re keeping an eye on their competitors, and they think, well, we need to keep up with that. So we need to have an opinion on this as well. And I mean, there’s a time and a place for jumping on trends, especially if it’s something if it’s something that there is an expectation on that company to respond to, like a world event, but it needs to be part of their overall strategy for it to be effective. Otherwise, it’s just, it’s just reactive. It’s kind of fire fighting. It’s, it’s not really cementing any like real foundation for the future. So yeah, those would be my two common pitfalls that I see. Christian Klepp  15:50 You’ll excuse me if I’m grinning here, but you’re the point you brought up just reminded me of a client that I worked with many years ago. I’m not going to say who it is to protect their identities, but they, part of the briefing was that they asked us to come up with a viral video, okay? And to which I said, you know, respectfully, respectfully, you don’t get to decide if your video is viral. That’s something that the market decides and and believe it or not, Jamie, it was in fact, it was in fact, a B2B campaign. So that that already in itself, made me scratch my head a little bit at the brief, yeah. And it was one of those moments where, okay, well, why are we why are we doing this, what are we hoping to achieve? What’s the outcome? And how is that exactly? How does that tie in, like you said to your business goals, right? And they basically said, Well, everybody’s, you know, something to the effect of all everybody’s doing one so, you know, we think, we think it’ll be good to do this as well. And I think those are one of those moments in my agency, days where we were very confident that we will be okay if we walked away from that project, and we did, we just said, like, Sorry, can’t help you, right? Because I just even in my my wildest dreams, I could not imagine how we would have been able to pull that off, not from a production perspective. Because, you know, if you want to make a video, that’s there’s many ways to do that. I didn’t know how to pull it off from a marketing, distribution perspective. You know what I mean, like, Jamie Thomson  17:37 that’s stuff that’s kind of out with your control as an agency, as the creator of the content, or even as a business like you said, viral videos are meant to be it’s not really something that’s meant to be manufactured. It’s like a bit of a yeah, there’s just too many anomalies that needs to come together for something to go viral. So it’s a very difficult thing to manufacture without, of course, like paying for views or that kind of thing. You know, I’m a big, I’m a big sort advocate of it. Sometimes what you don’t say that is as important as what you do see, you know, you don’t need to be everything to everybody all the time, Christian Klepp  18:21 Especially in B2B. Jamie Thomson  18:22 Yes. Christian Klepp  18:25 Can you just imagine? I mean, you mentioned a couple of industries now, finance, tech and energy. Can you imagine if you had an energy client now that was also trying to reach out to finance people? Jamie Thomson  18:33 Yeah, yeah. That’s the thing. It’s like, yeah. Businesses need to understand their audience and but more importantly, they also need to understand their positioning in industry, like, what is? What are they known as in the energy sector? Are they the scrappy upstarts? Are they the established, like an international company, who are respected because, because all these things influence the way that they communicate and and the way that they speak to their audience as well. And you know, if a viral video fits that strategy, then I guess, fair enough, if you can try and manufacture but more often than not, I would say it’s more about being consistent, sticking to the plan. It’s an expensive gamble. It is an expensive gamble. Christian Klepp  19:22 Expensive gamble. Yes, all right, in our previous conversation, you talked about, you know, it’s the credibility of a brand’s messaging that decides whether they’re shortlisted or ignored. Could you elaborate on that? Jamie Thomson  19:39 Yeah, I think, I think the sort of credibility anchor comes from the consistency side of things. If you are consistently communicating your messages in a way that is also consistent with brand voice. Then you are more likely to be remembered by people like I think there’s a marketing statistic that that says the average consumer. I know we’re talking about business to business, but people, in general, the average like consumer. They need 12 touch points in order to like for that to result in a sale for a business. And so that could be like, they need to see the same message 12 times before it really hits home, or before they realize that’s something that they need. I’d imagine it’s probably even higher on social media, where people are consistent with schooling. But given that sort of like 12 touch point, like the sort of demonstrates the need for how consistent you need to be in order to have the credibility. And if you’re not being consistent and you’re just saying the same thing as everybody else, then you are essentially becoming like an average brand like everybody else, and that’s forgettable, whereas, you know, the companies that are really sort of digging deep into their own data and their statistics and the signals that we are seeing in the industry that only they have access to, that they can make known in their communications, then those are the ones that are ultimately going to be remembered. Christian Klepp  21:14 Yeah, yeah, no, absolutely, absolutely. And on that note, if you could just walk us through how you think B2B. Marketers can use that messaging and copywriting to establish credibility, especially in the B2B context. We’re always talking about decision makers or buying committees, so we’re not always we’re not just talking about one person, right. We’re talking about, as the name suggests, a committee, so a group of people, right? Yeah. Jamie Thomson  21:42 And I mean, the way that I sort of generally do it is with clients. I host a workshop, and like during that workshop, we would first of all establish their messaging. So what is it that the business wants to see in the first place? And then we work out, like priorities, what messages are the most important for the specific channels that the business uses. And then you look at like more on the execution side of things like the tone of voice and the style and that kind of thing. But you know, businesses can do this themselves in house, following like a sort of simple three step like formula, essentially just deciding what they want to say, ie, their messages, which messages are the most important and how do they want to communicate? It like with the last part on the execution, that’s where LLMs can be useful, checking grammar, working things from notes, using it like to proof. But the initial idea needs to come from the business. So yeah, I think by following that process, it makes the ultimate like the sort of final content, appear more thoughtful, and people do pick up on that, like that. There’s a reason that reports and statistics and like white papers do well for generating leads. It’s because they’re they are genuinely useful. They’re thought leadership pieces, as opposed to just one person’s opinion, who is maybe the same as someone else’s or the opposite controversy for controversy sake? Yeah, people can really tell when, like, a piece of content has had a lot of thought into it businesses, notice that it’s just that’s the kind of content that resonates with people, like I said before, like, even, even though it’s business to the business, you’re still communicating to people, regardless of who the target audience is and the industry and the demographics, it’s still a person that’s making the decisions as to whether they’re going to use that company’s services or buy their products. Christian Klepp  23:54 Absolutely, absolutely. And I think another thing that can also be kind of fun to do in B2B, especially with white papers and reports, and what have you is to extract some of those, like nuggets, right? Extract some of those, some of that data. And I’m just gonna throw one of them out there, right? Like many years ago, we worked with a company that did the produced steel. And I can’t remember how much steel they produce, but they said, you know, we produce enough steel that can, you know, it’s enough to, you know, we can wrap the you can, you can wrap around the Earth four times, right, something along that line, right? Or, or even, even at home, like with a with a consumer product, so we have the plastic wrap, and it actually says on the packaging that this can cover an entire football field, right? Just facts where it’s almost like, did you know, or hey, by the way, right? And then you can get into something more serious too, because we, you know, we’re dealing with reports like that as well. Like, you know, last year, last year, most retail brands invested about month. 30% more on AI. And if you’re in the industry, you might be like, Yeah, I kind of knew that they were investing in AI, but all 30% more of their budget. What exactly are they investing in? And, yeah, that’s, that’s why you should download the reports. Jamie Thomson  25:20 Lots of information in the way that you presented to the public, it becomes interesting. And like, as you know yourself, that’s kind of the job of a copywriter, is to simplify that complex information. Like, you know that the fact that, like, the plastic wrapped around the world four times, like, that’s quite viable. I can visualize that as a consumer, and I think, oh, that’s that’s be cool. But if you just came through the cold, hard stats within context, or that’s sort of like visual with it, it doesn’t really mean much to me. And yeah, that’s kind of the job as communicators. And sort of B2B is to simplify that complex information. Look for the nuggets, and if you have a generally useful report that can be enough to give you, like, months worth of content, like on social media and sort of thought leadership articles, just like expanding on an idea within that report. So yeah, like, it might take a bit of investment up front, initially, to get the data, and get the process for gathering that data and getting the methodology in place. But once, once you’ve done that, and you’ve written the report, and it’s out there that gives you content for potentially months. Christian Klepp  26:32 Absolutely, absolutely. And I think that’s one of the challenges of a copywriter, right? Like, how do you there’s this expression in North America, like, how do you get more juice out of the squeeze, right? So, how do you stretch that? Give it, give it more longevity, right? Beyond, beyond. Well, here’s the report, off you go, right? Like, just like you said, like, stretch it out for you in like, months. You know, have more ammunition for, like, social, media content, you know, promotional content, perhaps even something on the website, something along that line, yeah. Jamie Thomson  27:07 I said, so the strategy has the words, if you have the strategy in place, then that stuff will follow, because you’ll have thought about it before the report was even published. So. Christian Klepp  27:18 Yep. Jamie Thomson  27:19 Yeah. Christian Klepp  27:19 Yep, absolutely, okay. I mean, on the topic of authority, give us some practical techniques for signaling authority across websites, campaigns and proposals. And I know this isn’t a one sentence answer, off you go. Jamie Thomson  27:35 Yeah.I think the first thing that comes to mind is taking a stance. And I don’t mean being controversial, but I mean having a clear idea of where the company stands in the industry, like what their positioning is. That in itself, is a useful technique. It’s not something that you can, like achieve overnight, but like with a workshop with someone and getting it all documented, that can give you a clearer sense of purpose as a business. I also think demonstrating, demonstrating expertise, like through thought leadership, content is a really useful technique for signaling authority. You know, if you know as a company, you may not even realize it, but you have access to data that other companies don’t. That in itself is unique, even if you don’t have as much data, or if your data says something different from your competitors, it’s still your day and it’s still useful. And that’s the kind of thing that can be turned into thought leadership content. You know, we’ve discovered that 50% of x, you know, prefers this. That kind of like insight driven. Like content is the stuff that generally performs well because people are naturally drawn to it and they find it genuinely useful. Yeah, I think it’s just that kind of idea of like social proof, like showing that you know what you’re talking about as a business, rather than simply telling people, because that’s what, that’s what, like LLM content tends to do. It makes vague claims that anybody can make, but you know, the proof is in the pudding, that the businesses that actually demonstrate their expertise are the ones that get remembered. And so yeah, that kind of comes through thought leadership stuff, which is data driven, even if as simple as, like social proof, like providing evidence of a case study that you have written with a client, or, like a business outcome that is a signal of authority that shows that you can back up. All the claims that you’re making in your messaging. Yeah, yeah, those would be my kind of, like, top two practical tips. Christian Klepp  30:12 Absolutely. Well, you’ve laid it out so beautifully. It sounds, it sounds, you know, on the from the outset, like, very easy to do, but we all know that. You know, in reality, it’s, it’s, it’s much more, much more challenging, right? Jamie, I know that you’re, you know you’re, you’re an award winning copywriter, and you’re not a sage, and your job is not to prophesy, but I’m gonna have to ask you to, like, assume that role for a second. All right, looking like just down the road with everything that’s going on now, and, you know, we’ve talked about AI and LLMs and whatnot. Perhaps some practical advice, as we’re now at, you know, at the time of this recording, at the beginning of 2026 what are some advice that you would give B2B companies who are saying like, yes, we would love to build our credibility, but AI and LLMs, you know that all seems to be creeping into everything that we do. Give us some advice on how to deal with that moving forward. Jamie Thomson  31:18 Yeah, that’s a good question. I think my sort of advice would be to take the time to understand your positioning and to document it. So, you know, it’s that kind of the way that the sort of marketing is going and the way that the industry is evolving. I do think the businesses that are going to like be here in the next 10 years are going to have that like longevity, are the ones that are kind of investing the time and now to understanding where they are positioned in their industry and where they want to be positioned in 10 years time. But crucially, like having it documented so that it’s being used consistently across the business you know from from sending internal emails to writing reports for the public. So from a practical point of view, that’s things like understanding like the business values and how the work the company is doing is a reflection of those values, and how that’s communicated to people. If it’s like a business that’s selling a product, like, what are the unique selling points of the product? What are the benefits to the end users? And how are we seeing that? You know, because in a lot of B2B industries, I think the sort of the strategy of competing on features is becoming a bit redundant. As technology improves. It’s quite difficult for companies to be able to claim unique features, because everybody can has access to the same tools. And so really, what if you flat that on its head, and you kind of look at look at it from the customer’s point of view, whether the customer choose one company over another that’s essentially got the same product or service that’s going to come down to like brand ability, and how much the company is able to like, empathize with the target audience, if they can really understand what their pain points are, then that business is ultimately going to choose that service over another, and that that comes down to, like, having it all documented, you may have, like, an intuition about what these things are, but as your business evolves, your intuition about these things will change and you’ll get scope creep, or you’ll want to jump on trends. If you do have it documented as an internal process, you’re more likely to stick to it in the future. And if you do get to the point that you want to change your positioning in industry, because you’ve maybe you’ve had more success than anticipated, or something in the market has changed, then that in itself should be a process. You should go back to the drawing board and look at what processes you have documented, and think what needs to be changed here before you are reactively moving in a different direction. That would be my advice to put my kind of like futurist cap on that’s, that’s what I would say.   Christian Klepp  34:23 Yeah, yeah. Well, that’s some pretty that’s some pretty solid advice. And, you know, thanks for sharing that. I totally agree. People have to understand their positioning in the market. Most importantly, also, they have to document it. It’s, it’s amazing how many companies I’ve worked with that don’t document that kind of, I wouldn’t call it a projection, but it’s almost like, okay, the positioning, what you know, and their vision, like, where do they what do they aspire to become? Right? I know that sounds like more individualistic, but you can, you can, you know, you can put that into the context of organization as well. Like, what do you aspire to become in 10 years and 20 years? Where’s this business going to go? Jamie Thomson  35:06 Absolutely, that’s it. Like something doing my own business with clients. Like, if someone asks me if someone’s going if a company is going through a rebrand and they need their website rewritten to reflect the new positioning, like, the first thing I suggest is, well, let’s get a workshop work out what you want to say. I’ll create a messaging guide for you, and I’ll create a total voice guide for you. And then sometimes you get a push back and you say, Well, why do we need that? I guess the answer is, well, I could rewrite your website. I could make it up as I go along, if you want, but not going to be anywhere near effect as effective as it would be if we have all this kind of important stuff documented in the first place, like, you need to have a structure, you have a plan, you have a strategy before the sort of the execution happens. And if you do the first part, well then, like, the actual execution of it, whether we’re talking about writing or or any other sort of like campaign that last 20% almost. It’s just like the icing on the cake, because when you get there, you already know what you want to see, how you want to see it, just kind of need to get, don’t get the content down, whether you’re whether it’s filming, whether it’s from heads key fingers to keyboard, that sort of 20% kind of comes a lot easier when there’s a plan, when there’s a structure in there from the start. Christian Klepp  36:29 Absolutely, absolutely. Jamie, this has been an incredible conversation. Thank you so much for coming on and for sharing your expertise and experience with the listeners. Please, quick introduction to yourself and how people out there can get in touch with you. And for those that are listening to the audio version of this recording, Jamie and I are actually color coordinated today. Jamie Thomson  36:53 We were emailing each other before making sure that we were. Christian Klepp  36:58 That’s it. That’s it. That’s it. Jamie Thomson  37:01 Thanks very much for having me on Christian like I said, like, I have listened to the podcast and myself over the over the past few months, and I’ve resonated with a lot of the sort of content that, like your your other guests have been putting out there. So yeah, it’s like, really a privilege to be on it. And yeah, like people can get in touch with me. Well, just explain who I am. I mean, my name is Jamie, and I’m a strategic copywriter and messaging strategist. And I run a copywriting studio called Brand New Copy, and I have done since 2013 and I help brands establish their messaging and their tone of voice through workshops and deliverables like thought leadership, articles, white papers, annual reports, website copywriting. And I also provide training to businesses, agencies and other copywriters. And I have a flagship course called the Brand New Copywriting course, which opposite the strategy behind copywriting. So yeah, if you wanted to get in touch with me, the best way would be through email, which is Jamie Thomson at brandnewcopy.com Christian Klepp  38:13 Fantastic, fantastic. And we’ll be sure to drop those links in the show notes when this episode is published. So once again, Jamie, thanks so much for your time. Take care, stay safe and talk to you soon. Jamie Thomson  38:22 Thanks, Christian. Christian Klepp  38:24 All right. Bye for now.

Maastricht Diplomat
Transition to the Euro: Economic necessity or Political signaling?

Maastricht Diplomat

Play Episode Listen Later Mar 1, 2026 13:35


On 1st of February, the euro became the sole legal tender in Bulgaria. However, there have been many speculations as to what pushed this change, what does this entail for the Bulgarian people and who is benefiting the most. Join us as we delve into these topics with 6 experts in their respective fields. 

Wellness Your Way with Megan Lyons
E278: Peptides 101: The Science of Cellular Signaling, Repair, and Longevity with Dr. Chris Renna

Wellness Your Way with Megan Lyons

Play Episode Listen Later Feb 24, 2026 54:47


This episode covers:A thoughtful, science-based conversation about peptides, designed specifically for the peptide-curious with Dr. Chris Renna. This isn't a sales pitch or a “everyone should be on peptides” episode (I'm not!). It's an honest conversation about where peptides may fit, and where foundational health still matters more.Dr. Renna is a family physician who graduated from the University of Texas and earned his medical degree cum laude from the University of North Texas Health Science Center. Early in his career, he realized traditional medical training focused on diagnosing disease rather than creating true health, so in 1992, he founded LifeSpan Medicine, a personalized, prevention-focused practice built on concierge support and 24/7 access to care. With more than three decades dedicated to helping patients optimize their health, he's become a nationally recognized leader in preventive medicine, as well as a published author and sought-after speaker.Links mentioned during this episode:LifeSpan Clinic: https://www.lifespanmedicine.com/our-teamFree Initial Consultation with Dr. Megan: https://p.bttr.to/3a9lfYk Lyons' Share Instagram: www.instagram.com/thelyonsshareJoin Megan's newsletter: www.thelyonsshare.org/newsletter

Headfirst: A Concussion Podcast
The Physiology of the Action Potential and Neuronal Signaling with Professor Amanda Ellison

Headfirst: A Concussion Podcast

Play Episode Listen Later Feb 24, 2026 71:02


Send a textIn this episode, we're honoured to be re-joined by Professor Amanda Ellison who disced all things about the brain and headaches on episode 92, Splitting: The Inside Story on Headaches Professor Ellison has published more than 80 peer-reviewed papers, earning close to 3,000 citations, with research spanning visual neuroscience, sensorimotor systems, and neuronal disruption in conditions such as migraine and headache disorders. Her work provides valuable insight into how the brain functions—and malfunctions—following injury or dysfunction.Alongside her academic research, Professor Ellison is a passionate science communicator and the author of Getting Your Head Around the Brain and Splitting: The Inside Story on Headaches, two widely respected books that translate complex neuroscience into accessible, real-world understanding.02:00 - The Love for Action Potentials04:20 – What is Neuron and Why are the Special?07:30 – It Does Not Like the Text Book11:00 – What is an Action Potential and What is the Physiology Behind it?24:30 –How Neurons Communicate 29:35 - The Story of Camillo Golgi and Santiago Ramón Cajal 34:35 – Chemical Signals of Action Potentials 43:50 – Mitochondria, ATP and Sodium Potassium Pumps47:00 – Conceptualizing it All54:10 – Fatigue, ATP and mTBI59:00 – Calcium's Role01:08:54 – Favourite Thing About Professor Ellison's WorkGoogle Scholar: https://scholar.google.com/citations?user=-z_DSs4AAAAJ&hl=enSplitting: Inside Story on Headaches (https://www.amazon.com.au/Splitting-Inside-Headaches-Amanda-Ellison/dp/1472971396) Getting Your Head Around The Brain: https://www.amazon.com.au/Getting-your-head-around-brain-ebook/dp/B09HZ9FVSR?ref_=ast_author_dp Subscribe, review and share for new episodes which will drop weekly Social media:Twitter: @first concussionFacebook: Headfirst: A concussion podcastInstagram: Headfirst_ Concussion  Email: headfirstconcussion@gmail.com

The John Batchelor Show
S8 Ep503: Alejandro Peña Esclusa of the Venezuelan opposition reports that following high-level US visits, Cuban assets began exiting Venezuela, with Delcy Rodriguez reportedly leading a directed government under US guidance signaling a major shift in in

The John Batchelor Show

Play Episode Listen Later Feb 23, 2026 1:49


Alejandro Peña Esclusa of the Venezuelan opposition reports that following high-level US visits, Cuban assets began exiting Venezuela, with Delcy Rodriguez reportedly leading a directed government under US guidance signaling a major shift in influence.1912 CARACAS

The Low Carb Athlete Podcast
After 45: Why Protein Distribution, Leucine Threshold & mTOR Signaling Determine Whether You Build or Lose Muscle

The Low Carb Athlete Podcast

Play Episode Listen Later Feb 23, 2026 37:31


If you're over 45 and training consistently but noticing slower recovery, softer body composition, or declining strength — this episode is for you. In this deep-dive rabbit hole conversation, Debbie breaks down the real science of Muscle Protein Synthesis (MPS) and why protein distribution — not just total protein — becomes critical in midlife. You'll learn why 20–30 grams of protein often isn't enough anymore, why adults 45+ may need 3–4 grams of leucine per meal to fully activate mTOR signaling, and how anabolic resistance changes the muscle-building equation for both men and women. We also explore AMPK vs mTOR balance, chronic fasting and endurance training effects, insulin resistance, stress-driven cortisol interference, and how PNOĒ metabolic testing and genetic insights can personalize your muscle-building strategy. Midlife isn't decline — it's a threshold shift. When you understand the signaling, you can train smarter, fuel intentionally, and protect your metabolism for decades to come. Learn more about personalized testing and The FutureYou Blueprint™ at www.debbiepotts.net

Jack Westin MCAT Podcast
GPCR Signaling on the MCAT: Gs/Gi, Gq, and Signal Amplification

Jack Westin MCAT Podcast

Play Episode Listen Later Feb 23, 2026 43:54


In this Jack Westin MCAT Podcast episode, Mike and Molly break down MCAT signaling cascades with a clear, test-focused walkthrough of G protein–coupled receptors (GPCRs). You'll learn the core GPCR structure, how GDP → GTP activation works , why signaling pathways create amplification, and how cells shut signals off with built-in termination steps.We cover the high-yield cAMP pathway in detail, including Gs vs Gi, adenylyl cyclase → cAMP → protein kinase A (PKA), plus the key ideas behind the Gq pathway (PLC and calcium signaling). We also connect GPCR signaling to common MCAT contexts like hormones, fast cellular responses, and a classic passage-style example (cholera toxin) to show how the AAMC tests cause-and-effect in pathways.In this episode, you'll learn:

AP Audio Stories
Twin Milan and Cortina Olympic cauldrons are extinguished, signaling the end of Winter Games

AP Audio Stories

Play Episode Listen Later Feb 23, 2026 0:34


The 25th Winter Games have come to a close in Europe. Correspondent Gethin Coolbaugh reports.

People and Projects Podcast: Project Management Podcast
PPP 499 | How Much of Success Is Luck or Something Else, with Wharton's Judd Kessler

People and Projects Podcast: Project Management Podcast

Play Episode Listen Later Feb 21, 2026 45:34


Summary In this episode, Andy talks with Wharton economist Judd Kessler, author of Lucky by Design: The Hidden Economics You Need to Get More of What You Want. If you have ever looked at someone else's career success and thought, "They just got lucky," this conversation will give you a new lens. Judd introduces the idea of "hidden markets," the informal rules and systems that shape who gets opportunities, access, and scarce resources, even when money is not changing hands. They explore how leaders can evaluate allocation rules using Judd's three Es (equitable, efficient, and easy), why first come, first served "races" often reward availability more than merit, and how waiting lists can quietly shift costs onto the people least able to pay them. You will also hear Judd's "settle for silver" strategy, a practical way to make smarter choices in competitive markets, plus a thoughtful parenting angle on teaching kids to notice rules and incentives early. If you're looking for a fresh, research-backed perspective on how hidden rules shape who gets opportunities at work and in life, this episode is for you! Sound Bites "The goal of the book is to get people to start to recognizing these markets all around us." "In most of these markets, they play by a simple rule that we all understand, which is if you're willing to pay for the thing, then you get it." "Is the way that we're deciding who gets what... is it equitable? Is it efficient? And is it easy for market participants?" "I open my calendar and I see all these recurring meetings on my calendar, recurring meetings that were set up years or months ago. That's first in time, first in right." "If you understand the rules and develop strategies to get what you want from the market, then you actually can be one of the handful that actually gets the thing, that desirable outcome, and then it will look like you got lucky." "It's always going to be the folks who are in the market winning who are always going to think that it's fair." "Once you start thinking like, how am I actually allocating these things? That's when you've put on that market designer hat." "They'll come to you kind of with half-baked ideas because they know if they wait later on until they can fully bake the idea that the resources or the fun parts of the project might already be gone." "Part of what the Settle for Silver / Go for Gold Strategy is forcing you to do, is to think seriously about what you want and why you want it." "You, as a parent, you are designing the markets that your kids play in all the time." "We're not breaking the rules, but we are figuring out what they are so that we can put ourselves in a good position, and that's going to serve you well." "Maybe by being in the office, you are signaling your dedication to the firm that you're available for all of these opportunities." "If it's something that anybody can do, like send a quick email, right? That's, it's not actually costly. Anybody could send that email even if they're not truly dedicated and eager for the opportunity." "You cannot get all three E's for sure in any allocation mechanism. There's always going to be tradeoffs." Chapters 00:00 Introduction 01:41 Start of Interview 01:49 Growing Up and Thinking About Luck 03:00 Introducing Hidden Markets 07:10 The Three E's: Equitable, Efficient, and Easy 08:08 Live Event Tickets as a Case Study 12:50 High Frequency Trading and Hidden Races 15:21 Common Misunderstandings of the Three E's 17:04 Races Inside Organizations and Project Teams 20:25 Proximity, Signaling, and Opportunity at Work 23:03 Are We Selecting for the Right Behavior? 25:41 Stepping Back to Evaluate Your Own Systems 25:52 Colorado River Water Rights and Recurring Meetings 29:09 The Settle for Silver Strategy 30:57 The French Laundry Reservation Story 32:51 Settle for Silver in College Admissions 37:22 Helping Kids Recognize Rules and Incentives 41:03 End of Interview 41:32 Andy Comments After the Interview 44:34 Outtakes Learn More You can learn more about Judd and his work at JuddBKessler.com/book. For more learning on this topic, check out: Episode 265, a short video episode Andy put together about the topic of luck. Check it out! Episode 339 with Katy Milkman. Katy is the person who gave Andy the heads-up about Judd's book. In episode 339, they talk about her book How to Change: The Science of Getting from Where You Are to Where You Want to Be. It's a great discussion with another researcher who knows how to make the learning practical for all of us. Episode 372 with Annie Duke. Annie is a former world champion poker player who is a big fan of Judd's book. How does a poker player think about luck? Check out episode 372 to find out! Pass the PMP Exam This Year If you or someone you know is thinking about getting PMP certified, we've put together a helpful guide called The 5 Best Resources to Help You Pass the PMP Exam on Your First Try. We've helped thousands of people earn their certification, and we'd love to help you too. It's totally free, and it's a great way to get a head start. Just go to 5BestResources.PeopleAndProjectsPodcast.com to grab your copy. I'd love to help you get your PMP this year! Join Us for LEAD52 I know you want to be a more confident leader–that's why you listen to this podcast. LEAD52 is a global community of people like you who are committed to transforming their ability to lead and deliver. It's 52 weeks of leadership learning, delivered right to your inbox, taking less than 5 minutes a week. And it's all for free. Learn more and sign up at GetLEAD52.com. Thanks! Thank you for joining me for this episode of The People and Projects Podcast! Talent Triangle: Power Skills Topics: Luck, Hidden Markets, Behavioral Economics, Leadership, Decision Making, Resource Allocation, Organizational Design, Career Strategy, Signaling, Systems Thinking, Equity, Project Management The following music was used for this episode: Music: Echo by Alexander Nakarada License (CC BY 4.0): https://filmmusic.io/standard-license Music: Fashion Corporate by Frank Schroeter License (CC BY 4.0): https://filmmusic.io/standard-license

The John Batchelor Show
S8 Ep478: 0. Strained US-Canada Relations Under Trump Prime Minister Carney gains approval by standing up to Trump, signaling a shift in Canadian trade sovereignty despite costs. Guest: David Hebert

The John Batchelor Show

Play Episode Listen Later Feb 19, 2026 7:26


0. Strained US-Canada Relations Under Trump Prime Minister Carney gains approval by standing up to Trump, signaling a shift in Canadian trade sovereignty despite costs. Guest: David Hebert1904 RUSSO-JAPANESE WAR

Irish Tech News Audio Articles
UGREEN Expands Its NAS Lineup with New AI-Powered Flagship Series, Signaling the Era of the Smart Private Cloud

Irish Tech News Audio Articles

Play Episode Listen Later Feb 19, 2026 4:04


UGREEN has announced the upcoming launch of its latest flagship AI NAS models. By integrating artificial intelligence directly into private cloud storage, UGREEN is redefining how data is managed and used. Rather than serving simply as a passive repository, data stored on UGREEN AI NAS becomes an active digital asset, capable of being understood, retrieved, and utilised with greater efficiency. The iDX Series, which includes the UGREEN NASync iDX6011 and the NASync iDX6011 Pro, offers performance, intelligence, and privacy without compromise. The Full UGREEN NAS Family: Solutions for All Needs UGREEN's NAS portfolio is built around the real-world needs of different user groups, forming a versatile family that balances flexibility, ease of use, and scalable performance across a wide range of scenarios. The NASync iDX Series is the flagship, delivering ultimate NAS performance with AI-powered smart features and local LLM capabilities for power users with demanding storage and productivity needs. The NASync DXP Series provides scalable, pro-grade systems for enthusiasts, content creators, small teams, and more, combining advanced capabilities with a smooth, easy-to-use experience. For those just getting started, the NASync DH Series offers intuitive, easy-to-use devices that deliver secure, high-capacity storage alongside practical, time-saving management features. UGREEN's new AI NAS lineup redefines the private cloud with on-device intelligence at its core. By embedding AI directly into the system, UGREEN AI NAS enables faster access, smarter organisation, and stronger privacy without relying on the cloud. Flagship Specs and AI Capabilities The most powerful model in the series is the NASync iDX6011 Pro, which is powered by an Intel® Core Ultra 7 processor delivering up to 96 TOPS of compute, and features dual M.2 NVMe SSD slots along with 64GB of LPDDR5X memory as standard. With expandable storage up to 196TB, users can centrally manage photos, videos, and documents, while built-in on-device AI delivers smooth performance and keeps data private. Built-in AI tools save time and boost productivity, including Universal Search, Uliya AI Chat, AI Album, Voice Memos, and File Organisation. All processing for these practical features is done locally, keeping your data completely private and off third-party servers. UGREEN AI NAS is now available for super early bird pre-order on the official UGREEN website in the United States, Germany, and the United Kingdom. Customers can reserve their unit with a $30 deposit and enjoy savings of up to $1,040. The super early-bird offer runs until March, after which the product will launch on Kickstarter to reach a broader global audience. More about Irish Tech News Irish Tech News are Ireland's No. 1 Online Tech Publication and often Ireland's No.1 Tech Podcast too. You can find hundreds of fantastic previous episodes and subscribe using whatever platform you like via our Anchor.fm page here: https://anchor.fm/irish-tech-news If you'd like to be featured in an upcoming Podcast email us at Simon@IrishTechNews.ie now to discuss. Irish Tech News have a range of services available to help promote your business. Why not drop us a line at Info@IrishTechNews.ie now to find out more about how we can help you reach our audience. You can also find and follow us on Twitter, LinkedIn, Facebook, Instagram, TikTok and Snapchat.

Dr. GPCR Podcast
GPCR Location and Lipid Raft Signaling

Dr. GPCR Podcast

Play Episode Listen Later Feb 18, 2026 37:01


Key TakeawaysHow does the precise localization of GPCRs in lipid rafts reshape drug discovery strategy? Examine implications for functional assays and therapeutic innovation.Explore the pivotal role of GPCR-lipid raft compartmentalization in receptor signaling, desensitization, and pharmacology research. Dr. Keyvan Sedaghat discusses assay approaches, regulatory mechanisms, and the translational impact of bitter taste receptors beyond sensory biology. Leveraging decades of experience in assay development and database creation, he offers actionable insights for researchers optimizing GPCR drug discovery pipelines.Compartmentalization of GPCRs in lipid rafts directly influences receptor signaling and drug response.Desensitization pathways of dopamine D1 receptors depend on precise phosphorylation domains—challenging classical paradigms.Bitter taste receptors demonstrate functional relevance in non-gustatory tissues with emerging therapeutic applications.Database-driven research accelerates the identification of receptor-microdomain interactions for novel targets.Integration of computational modeling and biochemical validation is essential for advancing GPCR assay strategies.Dr. GPCR Links & ResourcesAccess the Dr. GPCR Ecosystem at https://www.ecosystem.drgpcr.com/ for community, tools, and databases.Details on Membership & Pricing: https://www.ecosystem.drgpcr.com/university-pricingGPCR Weekly News: https://www.ecosystem.drgpcr.com/gpcr-weekly-newsExplore Dr. GPCR Premium for expanded translational resources and networking.About the GuestDr. Keyvan Sedaghat holds a pharmacy degree and a PhD in cellular and molecular medicine, specializing in pharmacology, from the University of Ottawa. With over two decades of academic experience, he has served as a professor, senior lecturer, and chief scientific officer in the pharmaceutical and cosmetic industries. Dr. Sedaghat's work spans peer-reviewed publications and editorial roles across journals in molecular pharmacology, cell signaling, and G protein-coupled receptors. His scientific drive centers on unraveling molecular mechanisms underlying GPCR function and translating those findings into effective teaching, research, and drug discovery strategies.Guest on the Web:LinkedInGoogle Scholar

The Low Carb Athlete Podcast
PEPTIDES 101: Why Timing, Terrain & Signaling Matter More Than the Peptide

The Low Carb Athlete Podcast

Play Episode Listen Later Feb 17, 2026 33:25


Peptides are everywhere right now — in conversations about muscle, fat loss, recovery, longevity, and immune health. But here's the truth most people aren't talking about:

The Tara Show
H1, S2-2/16/26- Estrangement has become a form of moral signaling

The Tara Show

Play Episode Listen Later Feb 16, 2026 9:48


H1, S2-2/16/26- Estrangement has become a form of moral signaling

The Tara Show
H1-2/16/26- Today is President's Day, but plenty of things are going on in this country, Estrangement has become a form of moral signaling, Ms Pat on the WORD Talk line about the concept of Gov't Reboot

The Tara Show

Play Episode Listen Later Feb 16, 2026 32:44


H1-2/16/26- Today is President's Day, but plenty of things are going on in this country, Estrangement has become a form of moral signaling, Ms Pat on the WORD Talk line about the concept of Gov't Reboot

Immune
Immune Booster #22 T cell signaling and selection with Leslie Berg

Immune

Play Episode Listen Later Feb 10, 2026 44:49


Leslie Berg talks about her career studying T cell receptor signaling, T cell development, and the importance of mentors in her career.   Host: Cindy Leifer Guest: Leslie Berg Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Berg lab at University of Colorado Anschutz TCR thresholds and ITK (PNAS) Review on TCR signaling (Nat Immunol) Generation of TCR transgenic mice (Mol Cell Bio) T cell negative selection in TCR transgenic mice (Nature) Thymic exit of mature T cells in TCR transgenic mice (Cell) AAI past president Berg information Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Real Estate Espresso
What Employment Numbers Are Signaling.

Real Estate Espresso

Play Episode Listen Later Feb 10, 2026 6:10


We regularly look at macro economic data to forecast interest rates. Interest rates affect one of the three main variable associated with any project. Those three variables are construction costs, capital costs and rent. Everything else is a rounding error by comparison. We are expecting new payroll data from the bureau of labor and statistics later this week. However, those numbers are full of approximations and adjustments. To me, the most reliable data actually comes from private enterprise which is the real time payroll data from ADP. The ADP data is not a survey or a statistical sample. It's the real data taken from real payroll transactions in the past month. We're going to start with the employment data and then look at bond yields. We know that the Fed funds rate has dropped 75 basis points in the past year. But the yield on the 10 year treasury has hardly budged in spite of everything that has happened. So let's start with the payroll info and analyze from there. The latest ADP National Employment Report, released on February 4, 2026, indicates a significantly cooling U.S. labor market. Private sector employment grew by only 22,000 jobs in January, falling well short of the Dow Jones consensus forecast of 45,000.If we look by sector, the modest growth was almost entirely propped up by Education and Health Services, which added 74,000 jobs. Without this surge, the overall private sector numbers would have been negative.Treasury yields generally shifted lower as the market reacted to the signs of a rapidly cooling labor market. This trend was amplified by a "flight to safety" as investors moved out of riskier assets like equities and into the relative security of government bonds.------**Real Estate Espresso Podcast:** Spotify: [The Real Estate Espresso Podcast](https://open.spotify.com/show/3GvtwRmTq4r3es8cbw8jW0?si=c75ea506a6694ef1)   iTunes: [The Real Estate Espresso Podcast](https://podcasts.apple.com/ca/podcast/the-real-estate-espresso-podcast/id1340482613)   Website: [www.victorjm.com](http://www.victorjm.com)   LinkedIn: [Victor Menasce](http://www.linkedin.com/in/vmenasce)   YouTube: [The Real Estate Espresso Podcast](http://www.youtube.com/@victorjmenasce6734)   Facebook: [www.facebook.com/realestateespresso](http://www.facebook.com/realestateespresso)   Email: [podcast@victorjm.com](mailto:podcast@victorjm.com)  **Y Street Capital:** Website: [www.ystreetcapital.com](http://www.ystreetcapital.com)   Facebook: [www.facebook.com/YStreetCapital](https://www.facebook.com/YStreetCapital)   Instagram: [@ystreetcapital](http://www.instagram.com/ystreetcapital)  

Getting Hammered
2020 Vibes as Signaling is Up and Competence Down

Getting Hammered

Play Episode Listen Later Feb 4, 2026 70:37


Hosts Mary Katharine Ham and Vic Matus talk the Washington Auto show and generational shifts in car culture, plus their first cars! They delve into the Democratic drama of the Texas Senate race and the influence of social media on politics. The conversation also touches on the Grammys, the Kennedy Center's controversies, city dysfunction with school closures and trash heaps, and the Loudoun County School Board is absolutely insane again. Finally, they are trying to care about the Winter Olympics. Learn more about your ad choices. Visit megaphone.fm/adchoices

Room 101 by 利世民
學費增長速度為何高過通脹?

Room 101 by 利世民

Play Episode Listen Later Feb 3, 2026 56:55


在澳洲與美國等發達國家,學費升幅顯著超通脹。2026 年數據顯示,雪梨頂尖私校學費已突破每年 5 萬澳元大關,而全國獨立學校學費的平均漲幅達 7%,為整體通膨率的兩倍以上。「免費教育」神話:公立與私立的成本真相許多移民澳洲的家庭最初受「公立教育免費」的吸引,但現實中公校的隱形成本卻相當驚人。* 公立學校成本:澳洲教育理財機構 Futurity 估算,一名學生從幼兒園到 12 年級(K-12)的公校總成本約為 11.3 萬澳元。這包含校服、文具、戶外活動(如露營、博物館參觀)、電子設備(iPad/筆電)及昂貴的課後託管(After School Care)費用。* 私立與天主教學校:天主教學校 13 年總成本約為 24 萬澳元,而獨立私校則高達 37 萬至 46 萬澳元。頂尖私校如智朗文法學校(Geelong Grammar)2026 年的 12 年級學費更達到 55,380 澳元。教育經濟學:身分訊號與門檻效應高昂的學費所取代的不僅知識,更是 Signaling。* 身分篩選:頂級私校透過高學費與入學面試(評估家底匹配度)建立門檻,確保學生群體由特定的社會階層組成。* 訊號價值:所入讀的學校向未來僱主反映了學生的社會背景以及其家長所投入培養子女的資源,而非實際的創造及執行能力。* 補習軍備競賽:補習現象正由「補底」轉向「拔尖」,旨在普及教育中製造個人優異的假象,以爭奪社會上流的稀缺資源。區域差異與校區樓價的關係* 校區溢價:優質公立學校周邊的房價往往伴隨高額溢價;對於本地家庭而言,支付 10 萬至 20 萬澳元的房貸溢價,被認為是比支付雙孩高昂私校學費更經濟的選擇。* 選民結構:這些校區的家長,多為高學歷的亞裔新移民或中產階級,學歷水平比例往往遠超全國平均。制度與資金分配的爭議以澳洲為例,教育資金標準(SRS)旨在平衡社會不公,目前小學生人均撥款約 1.3 萬澳元,中學生約 1.7 萬澳元。然而,政府仍會對私校提供部分撥款(基於家長供款能力調整),這引發關於「教育公平」的激烈爭議,不少人呼籲將資源完全向公立系統傾斜。實力主義的冒起儘管傳統教育系統深陷競爭,但科技進步正提供新的突圍路徑。* 實力證明:GitHub 帳號、開源貢獻或 AI 工具應用能力,正逐漸取代單一的成績表,成為更有效的個人執行力證明。* 學習與制度的分離:隨著知識傳播成本降至零點,未來的學生應學會將「在學校獲得經歷」與「為自己累積實用技能」分開,以對抗文憑通脹與階級固化的困境。教育軍備競賽是社會對上流動機會減少的焦慮投射。雖然名校體系依然是權力與財富的交會點;但在成本與回報脫節的遊戲中,只會令一般人更難透過這個途徑突圍而出。 This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit leesimon.substack.com/subscribe

The John Batchelor Show
S8 Ep408: Alejandro Peña Esclusa reports that Cuban personnel are fleeing Venezuela as oil payments cease, signaling a crisis for Havana following Maduro's detention and the collapse of the socialist alliance that sustained both regimes.

The John Batchelor Show

Play Episode Listen Later Feb 2, 2026 12:38


Alejandro Peña Esclusa reports that Cuban personnel are fleeing Venezuela as oil payments cease, signaling a crisis for Havana following Maduro's detention and the collapse of the socialist alliance that sustained both regimes.1940 VENEZUELA

The John Batchelor Show
S8 Ep407: PREVIEW FOR LATER TODAY Guest: Edmund Fitton-Brown. Fitton-Brown explains Saudi Arabia denies airspace to U.S. forces to offer Iran a "fig leaf," signaling neutrality to maintain a fragile ceasefire with the Houthis.

The John Batchelor Show

Play Episode Listen Later Feb 2, 2026 1:15


PREVIEW FOR LATER TODAY Guest: Edmund Fitton-Brown. Fitton-Brown explains Saudi Arabia denies airspace to U.S. forces to offer Iran a "fig leaf," signaling neutrality to maintain a fragile ceasefire with the Houthis.1890 caravan

Theories of Everything with Curt Jaimungal
This Quantum Physicist Says The Wave Function Isn't Real: Rob Spekkens

Theories of Everything with Curt Jaimungal

Play Episode Listen Later Feb 2, 2026 167:56


From Ancient Egypt to Leibniz... Brand‑new interview out with Robert Spekkens of the Perimeter Institute, one of the sharpest minds working on quantum foundations. In 2004, he constructed a classical toy theory where your maximum knowledge is always incomplete—and out popped the no-cloning theorem, teleportation, and interference effects Feynman deemed impossible to reproduce classically. Spekkens compares our situation to Egyptian hieroglyphs before Champollion: a category mistake where we treat quantum states as descriptions of reality when they actually describe knowledge of reality. If you're interested in the topics above, you'll love this podcast. As a listener of TOE you can get a special 20% off discount to The Economist and all it has to offer! Visit https://www.economist.com/toe SUPPORT: - Support me on Substack: https://curtjaimungal.substack.com/subscribe - Support me on Crypto: https://commerce.coinbase.com/checkout/de803625-87d3-4300-ab6d-85d4258834a9 - Support me on PayPal: https://www.paypal.com/donate?hosted_button_id=XUBHNMFXUX5S4 JOIN MY SUBSTACK (Personal Writings): https://curtjaimungal.substack.com LISTEN ON SPOTIFY: https://open.spotify.com/show/4gL14b92xAErofYQA7bU4e TIMESTAMPS: - 00:00:00 - Defining Quantum Innovation - 00:06:40 - Realism vs. Empiricism - 00:12:12 - Leibnizian Methodological Principle - 00:23:40 - Causal Explanations of Correlations - 00:30:24 - Epistemic Quantum States - 00:41:00 - Foil Theory Methodology - 00:54:00 - Causal Influence vs. Signaling - 01:07:27 - Thermodynamics and Ignorance - 01:15:00 - Conceptual Understanding in Physics - 01:21:00 - Philosophy of Physics Utility - 01:30:00 - Speckins' Toy Theory Origins - 01:40:13 - Perimeter Institute's Ambitious DNA - 01:52:00 - PBR Theorem Implications - 02:05:40 - Ontic Separability Assumptions - 02:17:40 - Hieroglyphs and Category Mistakes - 02:29:00 - Revolutionizing Modern Physics - 02:37:20 - Unscrambling Causation and Inference LINKS MENTIONED: Journals, papers, books: - https://www.rwspekkens.com - https://pirsa.org/speaker/Robert-Spekkens - https://arxiv.org/pdf/2507.01122 - https://arxiv.org/pdf/quant-ph/0401052 - https://arxiv.org/abs/0706.2661 - https://arxiv.org/abs/quant-ph/0406166 - https://arxiv.org/pdf/2207.11779 - https://amazon.com/dp/1108066488?tag=toe08-20 - https://www.jstor.org/stable/687269 - https://plato.stanford.edu/entries/qm-copenhagen/ - https://plato.stanford.edu/entries/identity-indiscernible/ - https://www.fourmilab.ch/etexts/einstein/specrel/specrel.pdf - https://plato.stanford.edu/entries/spacetime-holearg/ - https://www.sciencedirect.com/topics/mathematics/hidden-variable-theory - https://www.nature.com/articles/299802a0 - https://arxiv.org/pdf/2011.01286 - https://link.springer.com/article/10.1007/BF02058098 - https://arxiv.org/abs/2005.07161 - https://www.sciencedirect.com/topics/engineering/maxwells-equation - https://www.einstein-online.info/en/spotlight/equivalence_principle/ - https://perimeterinstitute.ca/ - https://amazon.com/dp/9810241054?tag=toe08-20 - https://journals.aps.org/pr/pdf/10.1103/PhysRev.47.777 - https://arxiv.org/abs/1111.3328 - https://www.smithsonianmag.com/history/rosetta-stone-hieroglyphs-champollion-decipherment-egypt-180980834/ - https://www.sciencedirect.com/science/article/abs/pii/S0160932707000282 Videos: - https://youtu.be/gEK4-XtMwro - https://youtu.be/YWbjI-QsH2E - https://youtu.be/fU1bs5o3nss - https://youtu.be/NKOd8imBa2s - https://youtu.be/6I2OhmVWLMs - https://youtu.be/Tghl6aS5A3M - https://youtu.be/HIoviZe14pY - https://youtu.be/bprxrGaf0Os - https://youtu.be/4MjNuJK5RzM - https://youtu.be/c8iFtaltX-s - https://youtu.be/9AoRxtYZrZo - https://youtu.be/uOKOodQXjhc - https://youtu.be/3mhctWlXyV8 - https://youtu.be/gsSJPLX-BTA - https://youtu.be/FFW14zSYiFY - https://youtu.be/HhWWlJFwTqs Learn more about your ad choices. Visit megaphone.fm/adchoices

The Chad Benson Show
Punxsutawney Phil Sees His Shadow, Signaling Six More Weeks of Winter

The Chad Benson Show

Play Episode Listen Later Feb 2, 2026 110:02 Transcription Available


Punxsutawney Phil sees his shadow, signaling six more weeks of winter. The DOJ dumps millions more Epstein Files on Friday. Chad shares an update on the state of the midterm elections on Midterm Monday. Chad recaps the wokest moments from last night's Grammy's. The SNAP program officially has new work requirements. A U.A.E. firm quietly took a stake in the Trump Family's crypto company. A Democrat pulls a major upset in a deep red district in Dallas TX.

Lets Have This Conversation
Rethinking Regenerative Signaling Without Live Cells or Invasive Procedures with Dr. Tommy Rhee

Lets Have This Conversation

Play Episode Listen Later Feb 1, 2026 47:03


Cell-free regenerative medicine in athletes is a specialized and minimally invasive therapeutic modality that facilitates the repair and regeneration of musculoskeletal injuries—including tendonitis, ligament tears, and cartilage damage—through the direct delivery of concentrated bioactive molecules to the site of injury, rather than live, cultured cells. Proven Results (Anecdotal vs. Scientific): While numerous athletes have reported favorable outcomes—for instance, studies indicate as much as 70% improvement in pain and functionality—the National Institutes of Health notes that further scientific validation is warranted. Common Applications: These therapies are routinely utilized for chronic musculoskeletal conditions such as Achilles tendinosis, ACL/MCL injuries, and degenerative joint disorders. Dr. Tommy Rhee serves as a sports chiropractor, author, and innovator within the field of cell-free regenerative medicine. With clinical practice dating back to 2006 and more than two decades of experience in regenerative therapies, Dr. Rhee is recognized for his expertise in topical regenerative modalities. He has previously worked with the UCLA Athletic Department and was the team chiropractor for the Tampa Bay Buccaneers from 2015 to 2018. Acknowledging the limitations and risks associated with injection-based stem cell therapies, Dr. Rhee dedicated over three years to the development of RheeGen®, a patent-pending, cell-free topical regenerative platform designed to deliver regenerative signaling without the need for live cells or invasive procedures. Dr. Rhee is also the author of "The Future of Regenerative Medicine: Unlocking the Potential of Topical Stem Cell Therapy," wherein he examines the transformative impact of non-invasive, topical regenerative approaches on modern healing and recovery. His professional background encompasses elite sports medicine, clinical innovation, and prior service as a U.S. Navy aviator, affording him a distinctive perspective on performance, rehabilitation, and the evolving landscape of regenerative care. Please join us in welcoming Dr. Tommy Rhee. For additional information: https://rheegen.com/ Get the book: https://www.amazon.ca/Future-Regenerative-Medicine-Unlocking-Potential/dp/B0DYWXVDKP.   Learn more about your ad choices. Visit megaphone.fm/adchoices

WHRO Reports
Virginia Beach charter change bills pass in Richmond, signaling possible resolution of long voting rights fight

WHRO Reports

Play Episode Listen Later Jan 30, 2026 0:57


Steps remain to codify 10-1 district voting in Virginia Beach's city charter, but officials said there is opportunity to end years of uncertainty and litigation.

Calming Anxiety
Emergency Calm 4 Minutes to Stop a Panic Attack

Calming Anxiety

Play Episode Listen Later Jan 29, 2026 4:09


Is your nervous system in a state of high-stress or panic? Stop for just four minutes for this "Pocket Podcast" first-aid session designed to provide instant panic relief and vagus nerve regulation.In this guided 4-minute circuit, we move from the surge of overwhelming energy into a state of intentional calm. Using science-backed somatic grounding and vagus nerve resets, you will learn how to send a physical signal to your brain that the threat is over and you are safe. This session is designed for anyone needing an emergency nervous system reboot during high-anxiety moments.What's Inside the Circuit:Somatic Vagus Reset: Using eye movements and firm pressure to signal to the brain that you are safe.3-3-3 Grounding Method: A sensory technique to bring your mind back from the future and into the present moment.The 4-6 Breath: A specific exhale-focused breathing pattern that acts as an "off-switch" for your fight-or-flight response.Immediate Physical Grounding: Using cold water and floor-pressing techniques to stabilize your physical response.Episode Breakdown:[0:00] – Immediate safety anchor and physical grounding.[1:02] – Vagus nerve reset: Signaling the brain the threat is over.[1:51] – 3-3-3 Sensory grounding to return to the body.[2:32] – The 4-6 Breath: Deactivating the stress response.[3:23] – Integration and final grounding techniques.Take Back ControlIf you need deeper, permanent tools to manage your mental health, join the Anxiety Circuit Breaker Course. It features five guided hypnotherapy sessions designed to help you combat negative thinking and stop the spiral before it starts.Click the "Big Blue Button" at CalmingAnxiety.fm to enroll now.Become a supporter of this podcast: https://www.spreaker.com/podcast/calming-anxiety-guided-meditation-sleep-hypnosis-panic-attack-relief--4110266/support.Ready for More Calm?Thank you for listening to the Calming Anxiety Podcast, featuring guided meditation, mindfulness, and sleep hypnosis sessions with Martin Hewlett. Our mission is to provide you with proven tools for anxiety relief, stress reduction, and a path toward deep relaxation. Use this episode anytime you need to calm your mind and feel more at ease.

Stifel SightLines Podcast
Are Precious Metals Signaling Investor Worries?

Stifel SightLines Podcast

Play Episode Listen Later Jan 29, 2026 10:14


In this episode, we discuss gold’s surge as a potential signal of fiscal trajectory and sovereign-risk concerns, the roles of USD weakness, central bank buying, and ETF inflows.#Gold #FiscalTrajectory #USDollar #CentralBanks #ETFs #SovereignRisk #Markets #SightLines To read this week's Sight|Lines, click here. The views expressed in this podcast may not necessarily reflect the views of Stifel Financial Corp. or its affiliates (collectively, Stifel). This communication is provided for information purposes only. Past performance does not guarantee future results. Investing involves risk, including the possible loss of principal. Asset allocation and diversification do not ensure a profit or protect against loss. © Stifel, Nicolaus & Company, Incorporated | Member SIPC & NYSE | www.stifel.com See omnystudio.com/listener for privacy information.

The John Batchelor Show
S8 Ep346: SEGMENT 13: NATO'S DECLINE AND THE GREENLAND CRISIS Guest: Gregory Copley Copley argues the Greenland controversy reveals deeper fractures signaling NATO's erosion. Discussion examines how the alliance has weakened through neglect and divergin

The John Batchelor Show

Play Episode Listen Later Jan 21, 2026 13:50


SEGMENT 13: NATO'S DECLINE AND THE GREENLAND CRISIS Guest: Gregory Copley Copley argues the Greenland controversy reveals deeper fractures signaling NATO's erosion. Discussion examines how the alliance has weakened through neglect and diverging interests, European defensiveness over Arctic claims, and whether the transatlantic security architecture built after World War II can survive current political and strategic pressures.

The John Batchelor Show
S8 Ep346: SEGMENT 7: IRAN EXECUTIONS AND TRUMP'S PROMISE OF HELP Guest: Jonathan Schanzer (Washington, DC) Schanzer reports on the surge of executions inside Iran as the regime cracks down on dissent. Discussion covers Trump's remarks signaling support

The John Batchelor Show

Play Episode Listen Later Jan 21, 2026 11:44


SEGMENT 7: IRAN EXECUTIONS AND TRUMP'S PROMISE OF HELP Guest: Jonathan Schanzer (Washington, DC) Schanzer reports on the surge of executions inside Iran as the regime cracks down on dissent. Discussion covers Trump's remarks signaling support for the Iranian people, the brutal nature of the regime's repression, recent execution numbers, and whether American policy shifts could aid those suffering under Tehran's authoritarian rule.

The John Batchelor Show
S8 Ep326: ECONOMIC SLOWDOWN INDICATORS AND SECRECY AT THE WHITE HOUSE Colleague Jim McTague, Former Washington Editor of Barron's. Jim McTague observes unusually light traffic and retail activity in Washington, D.C. and Lancaster, signaling a potential e

The John Batchelor Show

Play Episode Listen Later Jan 17, 2026 8:58


ECONOMIC SLOWDOWN INDICATORS AND SECRECY AT THE WHITE HOUSE Colleague Jim McTague, Former Washington Editor of Barron's. Jim McTague observes unusually light traffic and retail activity in Washington, D.C. and Lancaster, signaling a potential economic slowdown. He notes blocked views of White House construction and predicts a recession driven by rising state taxes and the depletion of pandemic-era stimulus funds for local governments. NUMBER 161835

TheDailyGold Podcast
Episode 257: It Begins. Silver is Signaling a New Explosive Stage

TheDailyGold Podcast

Play Episode Listen Later Jan 15, 2026 40:12


0:00 Intro1:30 Silver Hourly Breakout3:00 Greatest Breakouts of All-Time7:20 Metrics for Strong Silver Target11:30 Acceleration not Blowoff Top14:00 De-dollarization, De-Globalization, No Sellers24:20 New Mercantilism31:20 SLV Failure Risk37:00 PSLV39:00 Vince's GoldFix

WITneSSes
Regenerative Medicine Stem Cell Signaling and Healing Without Surgery with Dr. Tommy Rhee

WITneSSes

Play Episode Listen Later Jan 15, 2026 22:45


In this episode of The Elisha Show, Dr. Tommy Rhee breaks down regenerative medicine in a clear, eye-opening way, explaining how stem cell signaling, not live cell injections, activates the body's natural healing power ⚡

Grace & Grit Podcast:  Helping Women Everywhere Live Happier, Healthier and More Fit Lives
Episode 415: Your Follow-Through Isn't Failing — It Is Signaling

Grace & Grit Podcast: Helping Women Everywhere Live Happier, Healthier and More Fit Lives

Play Episode Listen Later Jan 13, 2026 5:39


Learn to read the signals behind broken commitments and what they reveal about misalignment. If you want to take this work deeper, grab my book The Consistency Code: A Midlife Woman's Guide to Deep Health and Happiness. ✨ It's the roadmap midlife women are using to lead themselves powerfully in the health arena and beyond. Available now at https://theconsistencycode.com 

Empowered Patient Podcast
New Gut-Brain Signaling Drug Targets Prader-Willi Syndrome with Dr. Tien Lee Aardvark Therapeutics

Empowered Patient Podcast

Play Episode Listen Later Jan 8, 2026 16:41


Dr. Tien Lee, Founder and CEO of Aardvark Therapeutics, draws a clear distinction between appetite and hunger and the implications for treating metabolic conditions and managing weight. The Aardvark lead drug candidate, an oral bitter taste receptor agonist designed to activate the gut-brain connection to turn off hunger, is showing effectiveness in treating Prader-Willi Syndrome and general obesity.  There are also signs that this drug could be effective for those using GLP-1s to avoid nausea and prevent rebound weight gain experienced after discontinuing GLP-1 drugs. Tien explains, "That difference between hunger and appetite is the central thesis for our entire company, and your brain actually regulates how much you should eat. And it's driven by both appetite and hunger. So appetites like the carrot, and hunger is like the stick. Appetite is what you feel when you really enjoy a certain food, like ice cream or cake. And the appeal and the deliciousness of that food is a reward that your brain chases. Hunger is the feeling that you get when you have fasted for a prolonged period of time, and it really bothers you, and you feel real discomfort from not eating. And then at that point, food quality matters less, and you just want to escape that negative sensation. And we believe a lot of the current drugs are good at reducing appetite, but they don't so much address hunger like what our approach is pursuing."  "In obesity, there's probably a combination of both appetite and hunger at play. And they're both important. In fact, your body has both appetite and hunger that are regulated. And when we eat food, our gut releases a number of gut hormones that help tamp down and give us satiety for both appetite and hunger. However, there are certain conditions where hunger is the predominant issue. And with the disease that is our lead indication is a condition called Prader-Willi syndrome. It's a rare genetic disorder that affects about one out of 15,000 live births. And patients with this condition have this unabated, unrelenting hunger that they feel that really starts to manifest when they're about four or seven years old. And then characteristically, patients will even feel compelled to eat garbage to the point of stomach rupture if unregulated with their food access. So it's a very debilitating condition with a lot of suffering for the patients and their families."   "There are actually quite a number of new revelations in the scientific literature, and there's a greater appreciation of gut-brain signaling. So there are actually as many neurons in your gut as there are in your spinal cord, almost as many neurons as in the cat brain. And there's a greater appreciation of a two-way communication between your brain and the gut. So the vagus nerve is the largest nerve in your body, and there's actually a two-way communication between the gut and the brain. About 80% to 90% of the signal is actually from the gut to the brain. And even the drugs that people know currently, the Ozempic and the Zepbound drugs, are working through this gut path hormone. But naturally, a lot of the signals actually come from the gut to the brain through this vagus nerve conduction." #AardvarkTherapeutics #Hunger #Appetite #PraderWilliSyndrome #PWS #Hyperphagia #RareDiseases #BiotechInnovation #ObesityTreatment #GutBrainAxis #TasteReceptors #ClinicalTrials #Therapeutics #MetabolicHealth #PharmaceuticalInnovation  aardvarktherapeutics.com Download the transcript here

Empowered Patient Podcast
New Gut-Brain Signaling Drug Targets Prader-Willi Syndrome with Dr. Tien Lee Aardvark Therapeutics TRANSCRIPT

Empowered Patient Podcast

Play Episode Listen Later Jan 8, 2026


Dr. Tien Lee, Founder and CEO of Aardvark Therapeutics, draws a clear distinction between appetite and hunger and the implications for treating metabolic conditions and managing weight. The Aardvark lead drug candidate, an oral bitter taste receptor agonist designed to activate the gut-brain connection to turn off hunger, is showing effectiveness in treating Prader-Willi Syndrome and general obesity.  There are also signs that this drug could be effective for those using GLP-1s to avoid nausea and prevent rebound weight gain experienced after discontinuing GLP-1 drugs. Tien explains, "That difference between hunger and appetite is the central thesis for our entire company, and your brain actually regulates how much you should eat. And it's driven by both appetite and hunger. So appetites like the carrot, and hunger is like the stick. Appetite is what you feel when you really enjoy a certain food, like ice cream or cake. And the appeal and the deliciousness of that food is a reward that your brain chases. Hunger is the feeling that you get when you have fasted for a prolonged period of time, and it really bothers you, and you feel real discomfort from not eating. And then at that point, food quality matters less, and you just want to escape that negative sensation. And we believe a lot of the current drugs are good at reducing appetite, but they don't so much address hunger like what our approach is pursuing."  "In obesity, there's probably a combination of both appetite and hunger at play. And they're both important. In fact, your body has both appetite and hunger that are regulated. And when we eat food, our gut releases a number of gut hormones that help tamp down and give us satiety for both appetite and hunger. However, there are certain conditions where hunger is the predominant issue. And with the disease that is our lead indication is a condition called Prader-Willi syndrome. It's a rare genetic disorder that affects about one out of 15,000 live births. And patients with this condition have this unabated, unrelenting hunger that they feel that really starts to manifest when they're about four or seven years old. And then characteristically, patients will even feel compelled to eat garbage to the point of stomach rupture if unregulated with their food access. So it's a very debilitating condition with a lot of suffering for the patients and their families."   "There are actually quite a number of new revelations in the scientific literature, and there's a greater appreciation of gut-brain signaling. So there are actually as many neurons in your gut as there are in your spinal cord, almost as many neurons as in the cat brain. And there's a greater appreciation of a two-way communication between your brain and the gut. So the vagus nerve is the largest nerve in your body, and there's actually a two-way communication between the gut and the brain. About 80% to 90% of the signal is actually from the gut to the brain. And even the drugs that people know currently, the Ozempic and the Zepbound drugs, are working through this gut path hormone. But naturally, a lot of the signals actually come from the gut to the brain through this vagus nerve conduction." #AardvarkTherapeutics #Hunger #Appetite #PraderWilliSyndrome #PWS #Hyperphagia #RareDiseases #BiotechInnovation #ObesityTreatment #GutBrainAxis #TasteReceptors #ClinicalTrials #Therapeutics #MetabolicHealth #PharmaceuticalInnovation  aardvarktherapeutics.com Listen to the podcast here

The Metabolic Classroom
The Hidden Power of Ketones: Fueling + Signaling

The Metabolic Classroom

Play Episode Listen Later Jan 5, 2026 27:57


Listen ad-free by becoming an Insider: https://www.benbikman.comReferences:For complete show notes and references, we invite you to become an Insider subscriber. You'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, unlimited access to Dr. Bikman's Digital Mind, ad-free podcast episodes, show notes and references, and online, live Office Hours access with Ben. It also includes Ben's Weekly Research Review Podcast.

The EdUp Experience
Are Practical Majors Just Better at Cultural Signaling Than Skill Building? - with Dr. Corey Moss-Pech, Assistant Professor of Sociology, Florida State University

The EdUp Experience

Play Episode Listen Later Dec 22, 2025 44:10


It's YOUR time to #EdUp with Dr. Corey Moss-Pech, Assistant Professor of Sociology, Florida State University, & Author of Major Trade-Offs: The Surprising Truths about College Majors and Entry-Level JobsIn this episode, EdUp Extra series (because who doesn't love a little extra goodness in their life), sponsored by the ⁠⁠⁠ELIVE 2026 Conference in Denver, Colorado, April 19-22, & the 2026 InsightsEDU Conference in Fort Lauderdale, Florida, February 17-19,YOUR cohost is Zach Kinsler, Senior Solutions Engineer, BoodleboxYOUR host is ⁠Elvin Freytes⁠How does a sociology professor challenge the myth that practical arts majors succeed solely because of in demand technical skills versus cultural signaling?What happens when employers view an art history major as a risk rather than as a bundle of employable skills & critical thinking abilities?How could universities leverage their economic power to require employers recruiting at engineering fairs to also attend arts & sciences career fairs?Listen in to #EdUpThank YOU so much for tuning in. Join us on the next episode for YOUR time to EdUp!Connect with YOUR EdUp Team - ⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Elvin Freytes⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠& ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Dr. Joe Sallustio⁠⁠⁠⁠⁠● Join YOUR EdUp community at ⁠The EdUp Experience⁠We make education YOUR business!P.S. Want to get early, ad-free access & exclusive leadership content to help support the show? Then ⁠⁠​subscribe today​⁠⁠ to lock in YOUR $5.99/m lifetime supporters rate! This offer ends December 31, 2025!

NeuroNoodle Neurofeedback and Neuropsychology
Photobiomodulation, Epilepsy Neurostim, Autism EEG | NeuroNoodle Neurofeedback Podcast

NeuroNoodle Neurofeedback and Neuropsychology

Play Episode Listen Later Dec 18, 2025 61:59


Jay Gunkelman (500,000+ brains) & Dr. Mari Swingle (i-Minds) answer live viewer questions:✅ Photobiomodulation (red light) for dementia — real studies vs hype✅ Neurostimulation types: TMS, coils, photobio — epilepsy contraindication warning✅ Epilepsy: discharges shift sides, SMR beats surgery, Isabella case✅ Manual thresholds & learning curves — essential for real progress✅ ADHD/ASD evidence: strong for ADHD, emergent for autism (70% epileptiform)✅ Labels vs EEG: “missed learning phase” “learning disability”✅ Sensory processing: it depends — quiet or stimulate?

The John Batchelor Show
S8 Ep197: Professor Jonathan Healey recounts the humiliating refusal of Hull's governor to admit King Charles I, a key moment signaling open warfare. He discusses the irreconcilable ideological split over whether power derives from God or the people, ill

The John Batchelor Show

Play Episode Listen Later Dec 16, 2025 9:10


Professor Jonathan Healey recounts the humiliating refusal of Hull's governor to admit King Charles I, a key moment signaling open warfare. He discusses the irreconcilable ideological split over whether power derives from God or the people, illustrating the tragedy through figures like John Bankes who sought futile compromise. 1669 ALLEGORY OF THE REGICIDE

Dangerous INFO podcast with Jesse Jaymz
243 "Demons, DNA & Disclosure" ft. Karin Wilkinson, water has memory, signaling via Hollywood, UAP's, Jesse's UFO story, Bondi Australia "event", Candace v Erika

Dangerous INFO podcast with Jesse Jaymz

Play Episode Listen Later Dec 16, 2025 170:07


Send us a textTonight we welcome author, speaker, experiencer, UAP research analyst Karin Wilkinson to the show. Karin is a published author dedicated to providing research and support for individuals affected by alien abduction, helping them find answers and healing from their traumatic experiences. She's the author of Stolen Seed, Evil Harvest and she is a regular writer/contributor to our friend L.A. Marzulli's monthly newsletter, Politics, Prophecy and the Supernatural."For as early as I can remember, I have been abducted by non-human alien entities—possibly hundreds of times. I pray that I can utilize my experiences to glorify God, to share the truth, and to help others in any way I can," Karin.Today, Karin continues to explore the mysteries of UFOs and alien encounters through research, writing, and engaging public speaking.Karin's website: https://karinwilkinsonauthor.com/SUPPORT THE SHOWBuy Me A Coffee http://buymeacoffee.com/DangerousinfopodcastSubscribeStar http://bit.ly/42Y0qM8Super Chat Tip https://bit.ly/42W7iZHBuzzsprout https://bit.ly/3m50hFTPaypal http://bit.ly/3Gv3ZjpPatreon http://bit.ly/3G3Visit our affiliate, GrubTerra to get 20% off your next order of pet treats: https://bit.ly/436YLVZ SMART is the acronym that was created by technocrats that have setup the "internet of things" that will eventually enslave humanity to their needs. Support the showLeave Voicemail: https://www.speakpipe.com/DangerousInfoWebsite https://www.dangerousinfopodcast.com/Discord chatroom: https://discord.gg/8feGHQQmwgEmail the show dangerousinfopodcast@protonmail.comJoin mailing list http://bit.ly/3Kku5Yt GrubTerra Pet Treats https://bit.ly/436YLVZ Watch LiveYouTube https://www.youtube.com/@DANGEROUSINFOPODCASTRumble https://bit.ly/4q1Mg7Z Twitch https://www.twitch.tv/dangerousinfopodcastPilled.net https://pilled.net/profile/144176Facebook https://www.facebook.com/DangerousInfoPodcast/ Instagram https://www.instagram.com/dangerousinfo/Twitter https://twitter.com/jaymz_jesseYouTube https://bit.ly/436VExnFacebook https://bit.ly/4gZbjVa Send stuff: Jesse Jaymz, PO Box 541, Clarkston, MI 48347

The John Batchelor Show
S8 Ep176: The Trump Corollary: Reviving the Monroe Doctrine in Latin America: Colleague Ernesto Araújo discusses a new "Trump corollary" to the Monroe Doctrine reshaping U.S. policy in the Americas, signaling a more assertive stance against for

The John Batchelor Show

Play Episode Listen Later Dec 9, 2025 10:50


The Trump Corollary: Reviving the Monroe Doctrine in Latin America: Colleague Ernesto Araújo discusses a new "Trump corollary" to the Monroe Doctrine reshaping U.S. policy in the Americas, signaling a more assertive stance against foreign influence and authoritarian regimes; this shift is evident in Venezuela, where President Maduro appears to be negotiating his exit in the face of U.S. pressure, while in Brazil the administration of Lula da Silva faces significant instability due to a massive banking scandal linking the government to money laundering and organized crime, with the new application of the Monroe Doctrine suggesting the U.S. will favor political figures aligned with its security strategy. 1952 CARACAS

Endtime Ministries | End of the Age | Irvin Baxter
Gold, Kings, and the Coming War: What 2026 Is Signaling - Ep. 7210

Endtime Ministries | End of the Age | Irvin Baxter

Play Episode Listen Later Dec 9, 2025 58:30


Gold is spiking. Nations are pulling their reserves out of global banks. King Charles may be facing his final Christmas. And Israel now believes a major war is coming in the next twelve months. What does all of this mean?   Today, we're looking at the gold markets, the kings of the earth, and the warnings of war—and what 2026 may be signaling to the world. ⭐️: True Gold Republic: Get The Endtime Show special on precious metals at https://www.endtimegold.com 📱: It's never been easier to understand. Stream Only Source Network and access exclusive content: https://watch.osn.tv/browse 📚: Check out Jerusalem Prophecy College Online for less than $60 per course: https://jerusalemprophecycollege.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Huberman Lab
Master the Creative Process | Twyla Tharp

Huberman Lab

Play Episode Listen Later Dec 8, 2025 150:06


Twyla Tharp is a world-renowned dancer, choreographer and expert on the creative process. She explains how to achieve creative success by keeping a highly disciplined routine that ultimately allows you to bring your creative visions to life. She explains how to establish a central message for each project, how to think about your audience, navigate criticism and continually elevate your standards with daily actions. We discuss how one's view of hard work, competition and even your name can shape what you think you're capable of and ultimately achieve. This episode offers direct, practical advice from a world-class creator on how to access your inner vision, build a strong body and mind, and do your best work. Show notes: https://go.hubermanlab.com/Yx57rWq Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Mateina: https://drinkmateina.com/huberman Timestamps (00:00:00) Twyla Tharp (00:03:28) Focus & Creative Work, Tool: "Spine" of Creative Work (00:06:22) Creator & Audience Dynamic; Intention, Finances (00:11:57) Early vs Late Works, Learning & Selectivity throughout Career (00:15:59) Sponsors: Our Place & Eight Sleep (00:19:09) "Cubby-Holing", Career Change & Reputation (00:21:48) Creator Community & Selectivity; Success & Useful Failure (00:27:42) Work Process, Schedule; Selecting Dancers, Supporting the Arts, Expectations (00:32:36) Successful Performance; Beauty, Arts Compensation (00:36:22) Mikhail Baryshnikov, Ballet & Invention; Philip Glass, Minimalism (00:43:18) Knowledge vs Instinct, Taste; Avant Garde; Classical Training (00:47:05) Kirov Ballet, Kids, Uniformity; Body Types (00:52:13) Sponsor: AG1 (00:53:36) Movement, Body Frequency, Power (01:00:18) Creative Process, Spine; Idea, Habit (01:04:15) Rituals, Gym, Discipline; Farming, Quaker & Community; Communication (01:12:16) Communication, Signaling & Distance; Feeling Emotion (01:18:11) Boxing, Strength Training (01:21:41) Sponsors: LMNT (01:23:01) Ballet Barre Work, Fundamentals (01:29:09) Body's Knowledge, Honoring the Body, Kids & Movement (01:35:42) High Standards & Childhood; Wordlessness & Movement, Twins (01:41:31) Translator, Objectivity; Critics, Creator Honesty (01:46:50) Sponsor: Mateina (01:47:50) Evolution & Learning; Amadeus Film & Research (01:53:53) Medicine, Keto Diet; Ballet Training & Performance, Desire (02:00:50) Young Dancers & Competition, Intrinsic vs Extrinsic Reward, Hard Work (02:08:47) Tool: "The Box"; Ritual, Practice vs Habit; Honorary Degrees (02:13:37) Tool: Idea "Scratching"; Movement & Longevity, Apprentice (02:19:46) Aging & Less Movement, Fearlessness; Taking Up Space, Names (02:25:42) Acknowledgements (02:27:18) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The Darin Olien Show
Dr. Christopher Rogers: Stem Cells, PRP, and the Future of Orthopedic Healing

The Darin Olien Show

Play Episode Listen Later Dec 5, 2025 73:08


In this transformative conversation, Darin sits down with world-renowned regenerative medicine pioneer Dr. Christopher Rogers, a physician with over 25 years of experience, 80,000+ patients treated, and a global reputation for advancing non-surgical orthopedic healing. In this episode, Dr. Rogers breaks down the real science behind PRP, stem cells, cartilage regeneration, tendon repair, and why so many people are told to get unnecessary surgeries. This is a deep dive into the future of healing — and the intelligence already built into your own body.     What You'll Learn 00:00:00 Welcome to SuperLife: exploring sovereignty, healing & possibility 00:00:33 Sponsor: Energy Bits and Whole-Food Algae Nutrition as Dense as a Plate of Vegetables 00:01:51 Introducing Dr. Christopher Rogers: 25 Years, 80,000+ Patients, Regenerative Medicine Leader 00:03:28 Darin's Personal Stem Cell Treatment Experience & Early Results 00:04:17 Dr. Rogers' Journey from Sports Medicine to Regenerative Orthopedics 00:05:58 The Moment that Changed Everything: Discovering PRP as an Alternative to Surgery 00:06:45 The Dinner that Changed His Career: Meeting Dr. Arnold Kaplan, Discoverer of Mesenchymal Stem Cells 00:07:13 PRP: What it Actually Is, Why Dose Matters, and How to Use It Effectively 00:10:36 The Wild West of Stem Cell Therapy: Misinformation & The Need for Science 00:13:24 The Core Mechanism: Stem Cells Work by Signaling the Body to Heal 00:16:07 Exosomes, Nanotubes, and the Secret Communication of Stem Cells 00:17:45 Bone Marrow vs. Adipose vs. Culture Expansion: The Critical Dose Problem 00:22:28 Autologous vs. Donor Cells: Why Using Your Own is Safer and More Effective 00:24:51 Sponsor: Fatty15 and the Science of C15 for Mitochondrial & Cellular Health 00:28:32 The Path to Safety: FDA-Approved Trials and the Right to Try Law 00:35:44 The Next Step: Getting Regenerative Therapy Approved as Standard of Care 00:37:08 The Ultimate Excitement: Healing Rotator Cuffs and Alleviating Global Suffering 00:41:07 The Orthopedic Surgeon Who Treated Himself with Stem Cells 00:42:02 Four Rules to Avoid Falling Victim to Stem Cell Hype and Unproven Clinics 00:47:36 Sponsor: SuperLife Patreon 00:49:08 The Frustration of Unregulated Clinics Undercutting Real Science 00:51:36 The Future: What Stem Cell Therapy Will Look Like in 5-10 Years 00:56:25 Systemic Use: The Potential for IV Infusions to Modulate the Immune System 01:01:26 Stem Cells and Cancer: Is There an Increased Risk? (The Data Says No) 01:03:10 Unexpected Healing: A Full ACL Tear Healed with Regenerative Therapy 01:06:10 Chronic Pain and Lifestyle: Why Knees and Backs are the Biggest Challenges 01:09:32 Finding Quality Care: The Network of Trusted Regenerative Physicians 01:12:46 Closing Reflections: The Joy of Bringing Patients Back to an Active Life     Thank You to Our Sponsors: EnergyBits: Get 20% off your entire order by going to https://energybits.com/ and using code DARIN at checkout. Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout.     Find More from Dr. Christopher Rogers Website: San Diego Orthobiologics Medical Group Instagram: @sandiegoorthobiologics     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences     Key Takeaway "Your body was designed to heal — not just manage pain. When we stop suppressing symptoms and start supporting biology, we unlock the intelligence that's been there since the day we were born."  

Cosmic RX Radio with Madi Murphy
Reflecting on the Numerology, Astrology, and Collective Shadow Work of 2025 with Zoey Greco

Cosmic RX Radio with Madi Murphy

Play Episode Listen Later Dec 5, 2025 52:59


Send us a text2025 was a year of massive shifts and powerful transitions. But how can we just reflect, digest, and process it all so we can turn it all into fuel to be our baddest bitch selves as we go into 2026? In this episode of CosmicRX Radio, we sit down with Zoey Greco, beloved spiritual coach and podcaster, to reflect on 2025: from numerology to astrology, from the collective challenges to the personal breakthroughs, and more.Zoey Greco, also known as "The Merhipsy", is an intuitive empath and spiritual coach, whose work connects individuals to the divine guidance and unconditional love that awaits them in every moment from Universal energy. Through her podcast, her Intuition Activation Mentorship, and through her twice sold out Mystic Rebel Oracle and Crystal decks, Zoey helps others experience healing, discover community, and feel far less alone in their spiritual and personal journeys. She teaches others that we all have the power of intuition and can develop it with the use of many spiritual tools and modalities to manifest a life of endless possibilities.