Podcasts about mitochondria

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/TimAG1 all-in-one nutritional supplement: DrinkAG1.com/TimCresset family office services for CEOs, founders, and entrepreneurs: CressetCapital.com/TimTimestamps:[00:00:00] A meditative start.[00:02:19] Reflecting on our second Zen retreat in Santa Fe with Henry Shukman.[00:04:08] Ketone liver warnings and eggplant allergies: The perils of raiding Kevin's fridge.[00:08:06] “Just be still” — three simple words that miraculously shut down my OCD.[00:13:54] Is meditation secretly vagus nerve stimulation?[00:20:17] DIY vagus nerve stim for $25 vs. Kevin's $900 ear clip.[00:24:57] HeartMath and watching your HRV move in real time.[00:27:57] Marching toward 50: balance boards and the end of jiu-jitsu.[00:31:26] Tony Hawk snowboarding Hokkaido with screws in his hip.[00:33:01] Slacklining and why your nervous system needs sleep cycles.[00:35:19] Bertolotti's Syndrome: My six-year back pain gets a name.[00:37:09] The nerve block test: everything wrong, zero pain.[00:44:10] Abrahangs tendon protocol: 10 seconds on, 50 off.[00:46:24] The NUG: a pocket hangboard for travelers.[00:48:31] Craig Mod's Japanese toothbrush and Toaster's cameo.[00:50:45] Kevin's $92 vintage fire jacket: Blue Heritage Japan.[00:54:26] Podcast picks: The Power Broker and STEM Talk.[00:56:20] Alzheimer's: A plaque or mitochondrial problem?[00:57:30] 10 grams of ketones turns one-word answers into sentences.[00:58:40] Methylene blue on Amazon: 120 years of research, zero guardrails.[01:02:36] Bredesen Protocol, APOE genotyping, and a cognitive comeback.[01:05:32] Photobiomodulation: $30k laser to the forehead.[01:07:55] Urolithin A and the high price of mitochondrial upkeep.[01:14:56] Recipe for disaster pants: espresso + creatine + MCT oil.[01:17:39] Norwegian 4×4 training and lactate as a brain lever.[01:23:15] Blood flow restriction bands and schwantz ring koans.[01:29:08] Hummingbirds named Sunset and squirrel obstacle courses.[01:32:06] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episode Highlights With KatiePerimenopause vs menopause vs post-menopause (high level)Hormone replacement therapy (HRT): estrogen, progesterone ± testosterone, different delivery methodsWhy hormone replacement is such a hot topic right nowWhat the new HRT label changes do and don't meanMy core philosophy – foundations before hormones and why I'm cautious about jumping straight to HRTThe light & mitochondria lensCell danger response & safety signals and what that means for perimenopause & hormonesPros & cons of HRT as I currently see themWhat I'm actually doing now to prepare for perimenopauseResources MentionedUpgraded Formulas Trace MineralsEidon Multiple MineralsHealthy lightbulbsBONCHARGEI like so many of their products - from their red light products to their sauna blankets. Red light has been so helpful for me during my recovery from Hashimoto's. To find out more, go to boncharge.com/wellnessmama and use code wellnessmama for 20% off!BioptimizersI love and use so many products from them, but I especially love the magnesium and digestive enzymes. Visit bioptimizers.com/wellnessmama and use wellnessmama15 at checkout to get the best deal

Horses have tiny engines within almost every cell of their bodies, and each of these runs on fuel that comes from the food they eat. These engines are called mitochondria. This podcast describes these engines and what happens to our horses when they stop working efficiently. One thing is for certain: adding more fuel doesn't help them run better. The only way to improve the health of horses is to improve the way their mitochondria work. But is producing power the only thing mitochondria do? Research into mitochondria shows that these powerhouses of the cell were once bacteria with their own DNA, and they communicate with each other and insert snippets of their DNA into the human DNA. They also need time to clean up and repair themselves. They can operate on two different fuels, but exhaust themselves when running on only one, becoming stuck and unable to switch to the other. This leads to poor health, breakdowns, and premature death. ********** Community.TheHorsesAdvocate.com is a place to learn about horses, barns, and farms. Its information is free, and a membership option lets horse owners attend live meetings to ask questions and deepen their understanding of what they have learned on the site. Membership helps support this message and spread it to everyone worldwide who works with horses. The Equine Practice, Inc. website discusses how and why I perform equine dentistry without immobilization or the automatic use of drugs. I only accept new clients in Florida. Click here to make an appointment. The Horsemanship Dentistry School is a place for those interested in learning how to perform equine dentistry without drugs on 97% of horses. Thank you for sharing and "Helping Horses Thrive In A Human World."

In this episode, Dr. Jockers talks with Catharine Arnston about why algae may be one of the most overlooked tools for brain health, energy, and healthy aging. They unpack how spirulina delivers key nutrients that support memory, focus, and mitochondrial strength, while also helping the brain handle inflammation and oxidative stress.   Catharine explains why spirulina stands out for cognitive support, from its rich B vitamin content to its powerful antioxidant compounds that help protect neurons and cellular energy. You'll also hear how these nutrients may play a role in mental clarity, mood, and long-term brain resilience in ways most people never consider.   The conversation also dives into chlorella and its role in detoxification, especially when it comes to heavy metals and other environmental toxins that can affect both gut and brain health. As the episode unfolds, you'll learn how these two forms of algae work differently, when to use them, and why they may be a simple addition to a longevity-focused routine.   In This Episode:  00:00 Spirulina Nutrient Teaser 04:18 Brain Fog and Algae Rescue 07:33 Spirulina Brain Nutrients 14:25 Chlorella vs Spirulina Guide 20:46 Blood Brain Barrier Toxins 22:56 Menopause Mitochondria Iron 25:23 Iron vs Manganese Damage 26:50 Spirulina Nutrient Ladder 29:18 Algae Starter Dosing 30:53 Food Not Supplement 33:27 Detox Biohacks Cleanup 38:24 Spirulina Chlorella Protocol 44:05 Algae Lifeline Closing 46:18 Podcast Wrap Up   If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday.   Looking for a delicious snack that's good for you? Paleovalley Superfood Bars are packed with organic, whole food ingredients like collagen protein, kale, and blueberries—providing all the nutrients your body needs. With flavors like Lemon Meringue and Red Velvet, you can enjoy a treat that supports gut health, joint function, and even wrinkle-free skin. Visit paleovalley.com/jockers and use the code Jockers to save 15% on your order today.   It's time to take your oral care to the next level with BON CHARGE's Red Light Toothbrush – order yours today! For a limited time, my listeners get 15% off when you order from boncharge.com and use my exclusive promo code DRJOCKERS at checkout. You'll also get free shipping and a 12-month warranty. Go now to get this exclusive offer! That's boncharge.com with promo code DRJOCKERS to get 15% off. Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com - https://renewyourhair.com/drjm/DRJ.     "B vitamins found in spirulina can reduce dementia by up to 50%, helping to repair neurotransmitters and boost brain health."      Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio Resources: Visit paleovalley.com/jockers for a 15% discount  Visit boncharge.com with promo code DRJOCKERS to get 15% off Visit https://renewyourhair.com/drj   Connect with Catharine Arnston: Website: https://catharinearnston.com/ Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

Dr. Hoffman continues his conversation with Dr. Bret Scher, medical director of the Coalition for Metabolic Health.

Dr. Bret Scher, medical director of the Coalition for Metabolic Health, discusses making metabolic health the foundation of medicine amid rising obesity and type 2 diabetes and reports that 93% of Americans have suboptimal metabolic health. Scher defines metabolic health using markers including glucose, insulin, triglycerides, HDL, blood pressure, and waist size, and cites evidence linking insulin resistance to heart disease, stroke, cancer, psychiatric illness, and other complications. They discuss simple self- and lab-assessments (waist-to-height ratio, fasting insulin with glucose/HOMA-IR, triglyceride-to-HDL ratio, CGMs). Scher critiques the Eat Lancet report for assuming one optimal diet, reliance on low-quality nutrition epidemiology, potential nutrient shortfalls, and environmental oversimplification, while supporting newer dietary guidelines that allow lower-carb approaches. Part two covers contradictory nutrition studies, distinctions between low-carb and ketogenic diets, emerging “metabolic psychiatry” and ketogenic therapy for mental illness and cognitive decline, limits and rebound risks of GLP-1 drugs, and Coalition efforts to improve school food and influence policy.

What if a powerful longevity molecule could help protect your cells and support healthy aging?     In this fascinating episode of the Lisa Fischer Said Podcast, Lisa sits down with scientist and entrepreneur Chris Burres, co-founder of MyVitalC, to break down the science behind ESS60 (Carbon 60)—a molecule studied for its potential antioxidant and mitochondrial benefits. Chris explains how this Nobel Prize-winning molecule works inside the body, what the research says about its potential to reduce oxidative stress, and why it's gaining attention in the world of biohacking, longevity, and cellular health.     Lisa brings her signature humor and curiosity as they discuss hormone health, metabolism, inflammation, and why mitochondrial function plays such a critical role in energy, aging, and overall wellness. Chris also shares the surprising origin story behind Carbon 60 research and how it evolved into one of the most talked-about compounds in longevity science. If you're curious about cutting-edge wellness science and what might help you age better—not just longer—this episode is packed with insights.    

Nutrition debates today often feel more ideological than scientific. One of the biggest examples is the ongoing controversy around seed oils, where strong opinions exist on both sides but clear understanding is often missing.  In this episode, Ted speaks with nutrition scientist Christopher Masterjohn to explore the history and research behind seed oils, cholesterol, fatty liver disease, and oxidative stress. They also discuss why nutrition debates become polarized, how choline intake influences liver health, and why metabolic markers like glucose and lactate can offer useful insights into personal metabolism.   If you want a deeper, more nuanced understanding of one of the most debated topics in nutrition—and practical ways to think about your own diet—this conversation will challenge assumptions and expand your perspective. Listen now.  Today's Guest  Christopher Masterjohn  Christopher Masterjohn is a nutrition scientist with a PhD in Nutritional Sciences. His work focuses on metabolism, micronutrients, and the biochemical mechanisms that influence long-term health. Through his research, writing, and educational platforms, he helps people understand how diet, metabolism, and lifestyle interact to shape metabolic health.    Connect to Christopher Masterjohn  Website: https://www.chrismasterjohn-phd.com   Instagram: @chrismasterjohn   X: @ChrisMasterjohn   Substack: Harnessing the Power of Nutrients   YouTube: @chrismasterjohn  Podcast: Mastering Nutrition Podcast    You'll learn:  Why seed oils became widely promoted—and why the science remains controversial  How polyunsaturated fats influence oxidative stress and long-term disease risk  The overlooked role of choline in preventing fatty liver and supporting metabolic health  How tracking glucose and lactate can provide deeper insight into metabolic function    Chapters:  00:00 Introduction  02:43 Seed Oils Defined  04:20 PUFAs Oxidation Risks  05:53 Heart Disease History  07:51 Trials Cancer Concerns  10:49 Null Hypothesis Debate  18:34 Choline Fatty Liver  33:50 Added Oils and Real Life  39:40 Muscle Over Fat Loss  44:24 Accidental Deficits Example  46:14 Coaching Psychology Nuance  50:59 Lactate and Mitochondria  56:11 Wrap Up and Where to Find 

This week I interviewed the CEO of The Light System - Jarrod Barakett. The Light System is a luxury wellness technology designed to raise cellular voltage and help the body restore balance through light, color, geometry, affirmations, and frequency. We discussed how the light system can elevate healing, vitality, and emotional clarity. Along with how Jarrod's journey through loss, and physical trauma led him to the light system, and how light-based modalities can help you recover faster, raise energy levels, and operate at peak performance.Learn about The Light System: https://www.thelightsystems.com/--------How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/FREE Nutrition Cheatsheets:https://brian-getleaneatclean.beehiiv.com/subscribeClick to book a FREE 15 minute consult with Brian:https://calendly.com/bdgryn/15min------------Interested in Upgrading your Mitochondria, Improving Energy and Sleep! Check out Troscriptions: https://bit.ly/4ik5kK5Use Discount Code for 10% OFF: EATCLEAN----Watch Get Lean Eat Clean podcast video episodes on YouTube!YouTube.com/@briangryn3680----B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssV----My favorite health bars with clean ingredients!https://www.eatprima.com/BRIAN6816310% OFF with this link!

What if everything we've been taught about illness only tells half the story? In this episode, Darin dives into one of the most controversial debates in the history of modern medicine: germ theory versus terrain theory. While conventional medicine focuses on identifying pathogens and eliminating them, terrain theory asks a deeper question, why do some people get sick while others exposed to the same pathogen remain perfectly healthy? Tracing the history from Louis Pasteur and Antoine Béchamp to the economic forces that shaped the modern medical system, Darin explores how our internal biological environment, our terrain, may be the real determining factor in health and disease. From cellular voltage and mitochondrial function to microbiome diversity, inflammation, nutrition, toxins, and stress physiology, the science increasingly points toward one central truth: health is shaped by the environment inside the body. Most importantly, Darin breaks down the practical pillars of terrain optimization, simple but powerful daily choices that strengthen resilience, support immunity, and restore the body's natural balance. What You'll Learn The historical battle between germ theory and terrain theory Why exposure to pathogens does not automatically lead to disease The role of Louis Pasteur, Antoine Béchamp, and Claude Bernard in shaping modern medicine How the Flexner Report of 1910 reshaped medical education and marginalized holistic medicine Why modern healthcare often focuses on pathogens instead of the body's internal environment The importance of cellular voltage and mitochondrial health in disease prevention How the microbiome influences immunity, metabolism, and inflammation The surprising connection between vitamin D levels and immune resilience Why chronic inflammation is a central driver of modern diseases How stress, toxins, sleep, and nutrition shape the body's terrain The science behind grounding, sunlight, and circadian rhythm regulation Practical strategies for optimizing your internal terrain and strengthening resilience Chapters 00:00:00 – Welcome to the SuperLife podcast and the mission of building health sovereignty 00:00:33 – Sponsor: reducing plastic waste with Bite toothpaste tablets 00:02:47 – Introduction to today's topic: germ theory vs terrain theory 00:03:10 – Why Darin began exploring this controversial health debate years ago 00:03:54 – What if everything we've been taught about illness is only half the story? 00:04:35 – How our internal biological environment shapes disease susceptibility 00:05:10 – The importance of optimizing the body's internal terrain 00:06:00 – Looking back to the 1800s: the scientific battle that shaped modern medicine 00:06:17 – Louis Pasteur and the rise of germ theory 00:07:20 – The successes of germ theory: antibiotics, vaccines, and sterilization 00:08:01 – Antoine Béchamp and the foundation of terrain theory 00:08:45 – The concept of microbial polymorphism and environmental adaptation 00:09:40 – When microbes become pathogenic in weakened terrain 00:10:00 – Pasteur's alleged deathbed admission: "The microbe is nothing, the terrain is everything" 00:10:45 – Claude Bernard and the concept of the internal environment 00:11:00 – The Flexner Report and the restructuring of American medical education 00:11:45 – How holistic and integrative medical schools were shut down 00:12:30 – The rise of the pharmaceutical-centered medical model 00:13:00 – Why modern doctors often receive little training in nutrition 00:13:45 – The consequences of a pathogen-centered healthcare system 00:14:00 – How economic interests influenced the trajectory of medicine 00:14:20 – Sponsor: Manna Vitality mineral support and cellular optimization 00:16:11 – The science of terrain and how it shows up across multiple disciplines 00:16:47 – Bioelectricity and the role of cellular voltage in health 00:17:20 – The transmembrane potential and healthy cellular voltage levels 00:17:50 – Otto Warburg's discovery of low oxygen environments in cancer cells 00:18:30 – Dr. Jerry Tennant's research on voltage and chronic disease 00:19:00 – The microbiome revolution in modern science 00:19:30 – Why the body contains roughly 38 trillion microbial cells 00:20:00 – How gut bacteria influence immune response 00:20:30 – Research showing microbiome diversity affects viral susceptibility 00:21:00 – Why exposure to pathogens does not always result in illness 00:21:30 – The role of nutrition, sleep, and stress in immune resilience 00:21:55 – Vitamin D deficiency as a major predictor of disease severity 00:22:30 – Chronic inflammation as the root of modern disease 00:23:00 – Mitochondria: the cellular energy system 00:23:40 – How mitochondrial dysfunction contributes to chronic illness 00:24:00 – The connection between nutrient availability and mitochondrial health 00:24:30 – The pillars of terrain optimization 00:25:00 – Why minerals are foundational for cellular health 00:25:30 – Magnesium deficiency and inflammatory disease 00:26:00 – Building a mineral-rich diet for optimal physiology 00:26:20 – Invitation to the SuperLife Patreon community 00:27:55 – Supporting the microbiome through diet and lifestyle 00:28:20 – Why dietary diversity increases microbial resilience 00:29:00 – The importance of sunlight, grounding, and circadian rhythm 00:30:00 – Sleep and the brain's detoxification system 00:31:00 – Environmental toxins and the body's detox pathways 00:31:45 – Stress physiology and its destructive impact on the terrain 00:33:00 – Rebuilding resilience through lifestyle choices 00:34:00 – Final thoughts on reclaiming control over your health 00:35:17 – Closing message and end of episode Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order. Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order.   Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway: "The germ may be the match, but the terrain is the dry timber. Without the right internal conditions, the spark simply goes out. But when the terrain is depleted—when our bodies are stressed, inflamed, nutrient deficient, and toxic—that same spark can ignite disease. The power we have is in shaping the terrain every single day." Bibliography/Sources: Bai, Y., Ocampo, J., Jin, G., Chen, S., Benet-Martínez, V., Monroy, M., Anderson, C., & Keltner, D. (2021). Awe, daily stress, and well-being. Emotion, 21(4), 562–566. This research documents how individuals experiencing awe report lower levels of daily stress, putting stressors into perspective to increase overall life satisfaction. https://doi.org/10.1037/emo0000638 Becker, R. O., & Selden, G. (1985). The Body Electric: Electromagnetism and the Foundation of Life. A pioneering work documenting how bioelectric fields in the body regulate growth, healing, and immune function. https://www.amazon.com/Body-Electric-Electromagnetism-Foundation-Life/dp/0688069711 Chirico, A., & Yaden, D. B. (2018). Awe: A self-transcendent and sometimes transformative emotion. This chapter identifies awe as a complex emotion arising from vastness that facilitates connectedness and self-diminishment. https://doi.org/10.1007/978-3-319-77619-4_11 DiNicolantonio, J. J., O'Keefe, J. H., & Wilson, W. (2018). Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Published in Open Heart, this study highlights how magnesium deficiency is a silent driver of inflammatory disease states. https://openheart.bmj.com/content/5/1/e000668 Keltner, D., & Haidt, J. (2003). Approaching awe, a moral, spiritual, and aesthetic emotion. Cognition and Emotion, 17(2), 297–314. A seminal paper establishing the two central pillars of awe: perceived vastness and the need for mental accommodation. https://doi.org/10.1080/02699930302297 Sender, R., Fuchs, S., & Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. Published in Cell, this study provides the current understanding that human and microbial cells exist in roughly equal numbers. https://doi.org/10.1016/j.cell.2016.01.013 Warburg, O. (1956). On the origin of cancer cells. Nobel Prize-winning research published in Science establishing that cancer thrives in low-oxygen, low-voltage environments where cellular respiration is impaired. https://doi.org/10.1126/science.123.3191.309

Ever feel tired & anxious even when your labs look “normal”? Dr. Scott Sher explains how mitochondrial dysfunction & metabolomics reveal what's really happening at the cellular level & why optimizing your mitochondria changes energy, focus, & resilience. Meet our guest Dr. Scott Sherr is an integrative hyperbaric medicine specialist and co-founder of Troscriptions, the company behind the first commercial pharmaceutical-grade methylene blue product. He provides worldwide hyperbaric consultation, education, and advocacy. With nearly 6 years of clinical experience using methylene blue troches, he has developed protocols bridging mitochondrial dysfunction and nervous system recalibration. Dr. Sherr also co-founded Health Optimization Medicine and Practice (HOMe/HOPe), a nonprofit training clinicians in a 7-module framework for cellular health optimization. He is the founder of OneBase Health, developing next-generation sensor and app technology for health monitoring. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Your body operates as a holobiont—an ecosystem of human cells & microbes. True optimization requires influencing the entire internal network Data driven personalization beats influencer hype. Use targeted labs to build & adjust your own supplement stack over time Every organ system depends on cellular function. Optimize cells first before pursuing advanced protocols Metabolomics provides real time snapshots of unique biochemistry, guiding interventions based on actual needs Aim for optimal young adult biomarker ranges instead of settling for average aging norms Mitochondrial capacity drives cognition, recovery, & disease resistance. Most chronic issues trace back to energy dysfunction Chronic sympathetic activation locks the body in survival mode, draining cellular reserves & accelerating breakdown Short term mitochondrial support & stress downregulation create space for sustainable long term lifestyle upgrades Balanced excitatory & inhibitory neurotransmitters like GABA & glutamate support mood stability, anxiety regulation, & recovery Deep parasympathetic recovery unlocks greater cognitive & athletic return than constant stimulation or overwork Episode highlights 01:01 Holobiont concept: Why Dr. Sherr reframes biohacking as “biont hacking” 06:01 Sympathetic spiral of doom: How chronic fight-or-flight drains mitochondria 14:04 HRV as a nervous system barometer 21:25 Mitochondria beyond the textbook 41:00 Five root causes of mitochondrial dysfunction 48:50 Methylene blue as a mitochondrial bridge 50:58 GABA-glutamate imbalance in brain signaling 53:26 Obligatory pairs for GABA support 01:07:37 The parasympathetic edge for performance & recovery Links Watch it on YouTube: https://youtu.be/SImTojIu2aY  Full episode show notes: outliyr.com/252 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

In this episode, Dr. Kharrazian dives into one of the most challenging and important topics facing both patients and practitioners: chronic fatigue and pain syndromes.If you've ever wondered why fatigue and pain are such stubborn and complex complaints, or why so many patients feel stuck despite having normal lab results, this conversation is for you. Dr. Kharrazian explores the critical role of cellular energy production—specifically mitochondrial bioenergetics—in recovery from injury and in managing conditions like fibromyalgia and chronic fatigue syndrome. He breaks down how disruptions in energy pathways can cascade into mood issues, pain syndromes, and overall decreased resilience, and explains why simply treating symptoms isn't enough.This episode also underscores the importance of going beyond a “one-solution” mindset, urging practitioners to delve deeper into the mechanisms that affect their patients' energy levels. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromesTo become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. ⁠For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠00:00 "Understanding Fatigue and Bioenergetics"04:58 "ATP: Key to Energy and Health"08:00 "Optimizing Energy and Resilience"11:34 Mitochondria and Fatigue Factors15:57 Anemia and Energy Function Insights17:48 Mitochondria: Origins and Clinical Relevance20:56 "Inherited vs. Acquired Mitochondrial Issues"23:50 Mitochondrial Function and Enzymes27:31 "Functional Medicine & Health Resources"Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level? -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and Computer Science at Princeton University. Griffiths directs Princeton's Computational Cognitive Science Lab, a research group focused on understanding the mathematical foundations of human cognition, and the Princeton Laboratory for Artificial Intelligence. He is the coauthor of Algorithms to Live By and the author of the new book The Laws of Thought, and his award-winning research has appeared in Science, Nature, and the Proceedings of the National Academy of Sciences. Together, Dave and Tom go deep on the cognitive science behind human performance, brain optimization, and the surprising overlap between biohacking and artificial intelligence. They explore why your body filters reality before your conscious brain ever sees it, how your mitochondria function as a distributed cognitive network, and what that means for longevity, decision-making, and neuroplasticity. You'll Learn: Why AI models reveal that humans may be more "stochastic parrots" than we'd like to admit How your mitochondria pre-process sensory reality before your auditory cortex even fires Why emotions like anger, love, and remorse are computational tools evolution built into your reward function How low energy and blood sugar directly degrade your decision-making at a hardware level What "resource rationality" means and how to use it to make better decisions under constraint Why AI systems have measurable psychological personalities, and which ones are least likely to mess with your head How neuroplasticity can eliminate the inner critic and reshape your mental operating system Why two-process cognition (fast and slow thinking) is a feature, not a bug, of human intelligence Thank you to our sponsors! -BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.-Quantum Upgrade | Try it free for 15 days — no credit card required — at QuantumUpgrade.io/DAVE. Simple. Powerful. Backed by data.-Go to timeline.com/dave and save 20% with code DAVE20 Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: AI, cognitive science, Tom Griffiths, The Laws of Thought, Princeton, brain optimization, neuroplasticity, mitochondria, decision-making, biohacking, Dave Asprey, human performance, longevity, anti-aging, consciousness, large language models, dopamine, reward function, resource rationality, emotions, game theory, altered states, chronic fatigue, dual process theory, Danger Coffee, Smarter Not Harder, cognitive biases, memory, AI bias, neurofeedback, Algorithms to Live By Resources: • Get Tom's new book: https://www.amazon.com/Laws-Thought-Quest-Mathematical-Theory/dp/1250358353 • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro00:50 - Tom's Background & Chronic Fatigue 10:22 – Mathematics of Mind 12:43 – Memory and Emotion 15:29 – Decision Making Under Constraints 21:10 – Computational Problems of Consciousness 24:18 – Reality Pre-Processing 26:14 – Meat Robots vs Stochastic Parrots 29:21 – Emotions: Game Theory 35:39 – Dual Systems: Model-Based vs Model-Free 39:22 – Mitochondria and Consciousness 50:00 – Testing AI Like Humans 52:11 – Choosing AI Models 57:14 – AI Research Questions See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Zone two has been sold to you as the gold standard for mitochondrial health, fat burning, and longevity. But what if it was built on culture, not science. In this episode, I sit down with Kristi Storoschuk, a PhD researcher whose work is challenging some of the biggest claims in the exercise world right now. We break down why zone two training lacks the scientific evidence everyone assumes it has, why higher intensity zones three and four are actually more potent for mitochondrial adaptation, and why the 80/20 training split from elite athletes was never designed for someone exercising four days a week. We also get into why fasting doesn't activate the same cellular pathways in humans as it does in rodents, why cortisol from exercise is not the same as chronic stress, the truth about fasted exercise for women, and what lactate actually tells us about our metabolic health. Kristi also shares her current research in collaboration with Dr. Andy Galpin and Dr. Tommy Wood on whether lactate threshold can serve as a non-invasive proxy for mitochondrial content. This conversation will completely change how you think about every cardio session you've ever done. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: Was Zone Two Built on Culture, Not Science? 03:19 The Three Exercise Intensity Domains (Not Five Zones) 08:00 Zone Two and Fat Burning: What the Research Actually Shows 12:00 Why Women Are Being Scared Away from Zone Three and Four 20:45 Fasting in Rodents vs. Humans: The Research That Changed Everything 24:00 Fasted Exercise and Cortisol: The Real Story for Women 29:00 What Lactate Actually Tells Us About Mitochondrial Health 37:00 VO2 Max, Mitochondria, and Longevity 43:30 Exercise as Your Daily Metabolic Reset 49:00 The Best Cardio Prescription for Healthspan 55:30 How a 73 Year Old Should Think About High Intensity 58:00 How to Know What Zone You're In Without a Monitor 01:02:00 Sex Differences in Exercise: What the Data Actually Says _______ Thank you to our sponsors Function health: https://www.functionhealth.com/louisanicola Timeline: http://timeline.com/NEURO Jones Road Beauty: https://www.jonesroadbeauty.com And Use code NEURO Lifeboost coffee : https://lifeboostcoffee.com/ and Use code NEURO for 10% off Just Thrive: https://justthrivehealth.com/NEURO _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

Today, I'm joined by the extraordinary Dr. Natalie Yivgi-Ohana, a pioneering scientist whose passion for mitochondria unlocks new frontiers in longevity medicine. Our conversation truly blew my mind—Dr. Yivgi-Ohana brings decades of expertise to demystify these tiny, ancient powerhouses that fuel every cell in our bodies, impact our hormones, drive immunity, and, as it turns out, play a central role in how we age.   Episode Timestamps: Welcome to the Longevity Podcast and today's focus on mitochondria ... 00:00:00 Maternal inheritance and critical functions of mitochondria ... 00:05:56 Mitochondria as energy producers and hormone regulators ... 00:07:03 Aha moments: mitochondria control life, death, and disease ... 00:08:55 Endosymbiotic theory: how mitochondria originated ... 00:10:19 Chronic disease, aging, and the connection to mitochondria ... 00:16:10 Substrate fuels: carbs, fats, and importance of metabolic flexibility ... 00:20:18 Mitochondria's control over immune system and signaling ... 00:26:39 Mitochondrial transfer: how cells share organelle "powerhouses" ... 00:32:42 Groundbreaking therapy: transplanting mitochondria for rare diseases ... 00:36:40 Expanding mitochondrial therapies to age-related diseases ... 00:42:57 Aging in women: hormones, mitochondria, and inflection points ... 00:51:00 Stem cell exhaustion and cellular renewal ... 00:52:24 Biomarkers: ways to measure mitochondrial health ... 01:03:11 Supplements, lifestyle, and emotional health for mitochondria ... 01:15:47 Medication choices and minimizing mitochondrial toxicity ... 01:24:04   Our Amazing Sponsors: O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off.   Magnesium Breakthrough by BIOptimizers — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at bioptimizers.com/bionat with code BIONAT   Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Dr. Bill Lawrence Episode

True wellness isn't about chasing symptoms—it's about understanding the internal communication systems that allow the body to repair, adapt, and thrive. In this episode, Dr. Greg Jones is joined by Dr. Kathleen O'Neil-Smith, a Harvard-trained physician and pioneer in peptide therapy, to explore how peptides, mitochondria, and personalized medicine work together to support resilient, long-term health.As a founding board member of the International Peptide Society, Dr. Kathleen explains how small signaling proteins orchestrate large-scale healing by influencing cellular communication, inflammation, metabolic efficiency, and recovery. The conversation highlights why mitochondrial health sits at the foundation of longevity and how modern medicine often overlooks the body's innate capacity to heal.Moving beyond trends and surface-level protocols, Dr. Kathleen shares how peptide therapy integrates with hormones, gut health, nervous system balance, and lifestyle to create durable clinical outcomes. They also discuss why one-size-fits-all medicine consistently fails patients, and how clinicians can think more strategically about restoring resilience rather than suppressing symptoms.

Today we're going deep — microscopic deep.We're talking about mitochondria.Now don't let that word intimidate you. This is not a high school biology lecture. This is about your energy, your metabolism, your brain clarity, your ability to burn fat, your resilience to stress — and yes, even how fast you age.Because mitochondria are the spark plugs of your cells.

Animal products contain aging toxins like dioxins and PCBs. Learn how a plant-based, SOS-free diet dramatically slows cellular aging. #PlantBased #AntiAging #Toxins #HealthTalks

In this episode, Jim sits down with Al Sanchez, an engineer-turned-health advocate who represents Poly MVA, a nutraceutical designed to support cellular energy production. Al shares how losing his mother and sister to illness set him and his father on a lifelong journey exploring alternative and integrative health therapies.Al breaks down complex concepts like mitochondria and metabolism in plain language, explaining why cellular energy is at the root of everything from immune function to brain clarity. He makes the case for what he calls "common sense medicine", addressing the basics like hydration, nutrition, sleep, stress reduction, and movement before reaching for pharmaceuticals.The conversation covers the role of Poly MVA in supporting mitochondrial function, how stress silently undermines our health, why animals offer powerful proof of supplement efficacy (no placebo effect!), and how lifestyle choices can actually change the expression of our genes. Al also warns listeners to steer clear of internet "miracle cures" and stick to therapies with a proven track record.A practical, energizing conversation full of relatable analogies, from cars to plants to kindergartners, that makes the science of healing genuinely accessible.HealingStrong's mission is to educate, equip and empower our group leaders and group participants through their journey with cancer or other chronic illnesses, and know there is HOPE. We bring this hope through educational materials, webinars, guest speakers, conferences, community small group support and more.Please take advantage of our FREE resources below to help you along your health and healing journey: Support Group Directory Holistic Curriculum - Participant Guide Support Our Mission - Donate Additional Health Resources Listen to Previous Episodes Website: healingstrong.org

In this episode, we sit down again with veterinary epidemiologist and Fatty15 co-founder Dr. Stephanie Venn-Watson to explore the emerging science behind C15:0, an odd-chain saturated fatty acid increasingly recognized as potentially essential for human health. The conversation begins by addressing skepticism and online claims that C15:0 research is a "scam," before diving into the human and epidemiological evidence showing that higher circulating levels of C15:0 are associated with lower cardiometabolic disease risk. Dr. Venn-Watson explains why not all saturated fats behave the same biologically, contrasting C15:0 with C16 and highlighting C15:0's unique properties including anti-inflammatory effects, mitochondrial support, and protection against cellular stress. Together they explore how modern dietary patterns may have reduced natural intake of this nutrient, what the latest clinical and mechanistic research suggests about aging and metabolic health, and why continuing to challenge long-standing nutrition dogma requires following the data wherever it leads. ----- 00:00 – The "C15 Essential Fatty Acid Scam" Debate 02:08 – Why Critics Say There Isn't Enough Human Evidence 06:35 – Dolphin Research That Led to the Discovery of C15 11:15 – Epidemiology: Higher C15 and Lower Cardiometabolic Risk 16:05 – Saturated Fat: Why the Narrative May Be Oversimplified 21:30 – C15 vs C16: Not All Saturated Fats Are the Same 27:05 – What Makes a Fat Truly "Essential" 32:10 – The "Goldilocks Fat": Why C15 Stands Out 38:20 – Anti-Inflammatory vs Pro-Inflammatory Fats 44:40 – Mitochondria, Cellular Stability, and Longevity 51:15 – Ferroptosis and Protecting Cells From Oxidative Damage 57:50 – Are We Aging Faster Without Enough C15? 1:05:10 – Why Modern Diets May Be Lower in C15 1:12:30 – How Scientists Follow the Data, Even Against Dogma 1:21:50 – What "Ever Forward" Means in Science and Life ----- Episode resources: Stephanie's first appearance on the show in episode 832 Save 15% with code EVERFORWARD at https://www.Fatty15.com/everforward

Send a textMitochondria in human evolution, climate adaptation, maternal genetics, aging, and disease.TOPICS DISCUSSED:Endosymbiotic theory: Mitochondria arose from oxidative bacteria engulfed by archaea-like hosts, confirmed by phylogenetic analysis.Maternal mtDNA inheritance: Mitochondrial DNA is inherited from the mother, not the father. There are adaptive reasons for this.Haplogroups & adaptation: Tropical lineages tightly couple energy production for efficiency; northern ones uncouple to generate heat.Heteroplasmy & aging: Mixed mutant and normal mitochondria accumulate in cells, eroding energy in high-demand tissues like brain and heart.Bioenergetics in disease: Many common conditions, from Parkinson's to cancer, stem from mitochondrial-nuclear interactions rather than nuclear genes alone.Ketogenic diets: High-fat intake fuels mitochondrial beta-oxidation, which may compensate for brain energy deficits in epilepsy and bipolar disorder.Warburg effect: Cancer cells shift to glycolysis to prioritize biosynthetic building blocks over maximal ATP production.Modern mismatches: Global travel pairs ancestral mtDNA with mismatched diets and climates, raising risks for metabolic dysfunction.ABOUT THE GUEST: Douglas Wallace, PhD is a geneticist and evolutionary biologist who has studied mitochondria for over 50 years. He currently directs the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia and the University of Pennsylvania.RELATED EPISODE:M&M 260 | Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha MuruganSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

What if the water you drink could change your brain, your energy, and even how you age?In this episode, I sit down with Mario Brainovic, researcher and founder of Analemma Water, to explore the concept of “coherent water” and how modern environmental stressors like EMFs may be disrupting the structure of the water in and around us. We dive into the science behind water coherence, brainwave changes, mitochondrial energy (ATP), NAD levels, and what this could mean for brain fog, fatigue, sleep, and long-term cellular health in midlife women. Mario shares the results of double-blind human studies, plant research, and emerging data on how structured water may impact heart rate variability, microbiome diversity, and overall resilience. This conversation stretches from hard science to big-picture thinking about energy, biology, and our connection to the natural world.This episode might change how you think about the most basic input your body receives every single day. Tune in now!Episode Timeline: 00:00 – Episode Overview04:06 – We Are Mostly Water06:17 – Chaotic vs Coherent Water08:17 – Why Water Structure Matters10:30 – What Is Coherent Water?11:46 – Twin Brainwave Study14:29 – Water and Brain Fog14:56 – ATP and Energy Production17:19 – Mitochondria and Aging19:47 – EMFs and Brain Impact21:07 – 5G Plant Experiment23:34 – Soil and Microbiome Study26:49 – How the Water Technology Works29:20 – Bathing and Heart Rate33:27 – NAD and Longevity35:36 – Water and Circadian Rhythm38:19 – Filtering vs Frequency42:21 – How to Get Started45:53 – Mission for Coherent PlanetConnect with Mario Brainovic:Instagram - https://www.instagram.com/mariobrainovic/?hl=en Company Website - https://www.analemma-water.com/

Chronic stress isn't just a mental or emotional burden. It creates a biological cascade that disrupts mitochondrial function, accelerates inflammation, and shows up visibly in the skin long before deeper symptoms appear.We dive deeper into this in the Biohacking Beauty Podcast with Dr. Scott Sherr. We also talk about the sympathetic spiral of doom, why skin reflects mitochondrial decline before other symptoms appear, and why sequencing interventions matter more than intensity.Dr. Scott Sherr is a board-certified internal medicine physician certified in Health Optimization Medicine (HOMe) and a specialist in Hyperbaric Oxygen Therapy. He is the COO of Troscriptions and focuses clinically on mitochondrial health, stress physiology, and advanced recovery protocols.What's Discussed:(01:52) Why chronic stress is not just mental and directly impacts cellular energy(05:17) How modern life keeps the nervous system stuck in chronic fight or flight(07:25) Cortisol and stress hormones disrupting mitochondria and accelerating skin aging(11:16) Why skin aging is often the first visible sign of mitochondrial decline(24:16) The sympathetic spiral of doom explained through energy loss and stress signaling(27:14) Why stress reduction and mitochondrial support must happen at the same time(46:22) Why aggressive skincare and biohacking fail without mitochondrial resilience(50:35) Hyperbaric oxygen therapy, sequencing, and why timing matters more than intensityFind more from Young Goose:The Elastin Action Protocol → Engineered for Skin Navigating Elasticity Change The Winter Skin Protocol → Build for How Skin Actually Behaves in Winter VAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment RecoveryUse code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareFind more from Dr. Scott Sherr:Website: https://troscriptions.comLinkedIn: @troscriptionsInstagram: @drscottsherr @troscriptionsFacebook: @TroscriptionsYoutube: @troscriptionsTiktok: @troscriptions

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice. Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise. This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology. You'll Learn: Why precision medicine outperforms population-based health strategies for human performance How to layer genomics, transcriptomics, and proteomics into one complete biological picture Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits The real story on metformin, peptides, and which supplements actually move the needle How AI can help you understand your own biology and act on it faster Why biohacking precision beats random stacking every time Thank you to our sponsors! • Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order. • BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com • Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. • Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs Resources: • Learn More About Anil's Work And the Institute For Human Optimization At: https://ifho.org/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:53 – Intro to Precision Medicine 01:58 – Dr. Bajnath's Holistic Health Journey 05:03 – Pharmaceuticals vs. Supplements 07:58 – Peptides and Longevity Molecules 10:34 – Sexual Health and Vitality 13:56 – Vascular Health and Blood Flow 15:14 – Multi-Omics Approach 19:03 – DNA and Genomics 22:17 – Transcriptomics and RNA 24:24 – Proteomics and Inflammation Markers 32:00 – The Human Exposome 34:55 – Key Health Biomarkers 36:58 – Cell Membrane Dynamics 40:28 – Biological Investment Strategy 41:53 – Life Extension Possibilities 48:52 – Bioenergetics and Mitochondria 49:47 – Quantum Medicine and the Future 51:33 – Vagal Nerve Stimulation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

80% of all autoimmune diseases occur in women, and no one can explain why. Cancer cells are always present in your body, but it's only when your T cells go into energy deficit that cancer starts overtaking the system. And here's what almost no one is talking about: the mitochondria in your immune cells are the reason MS, chronic fatigue, neurodegeneration, and even cancer progression happen when they happen. In this episode, I sit down with Dr. Anurag Singh, MD, PhD immunologist who spent 20 years studying mitochondria and screened 4000 compounds from pomegranates to discover one molecule that changes cellular aging. We break down immunometabolism, the emerging field linking immune health and metabolism, why your T regulatory cells are the CEOs of your immune system, how mitochondrial dysfunction in immune cells triggers autoimmune conditions, and why rejuvenating mitochondria can get your immune system in check to defeat cancer. We also cover NAD+ (and why NMN and NR supplements don't work the way people think), the creatine sweet spot for muscle quality (500mg-1g, not the 5g everyone's taking), why Parkinson's is linked to paraquat, a mitochondrial toxin used in fertilizers and dry cleaning and how AI is fast-tracking the discovery of next-generation molecules for neurodegeneration. This conversation completely shifted how I think about immune health, brain protection, and what's actually driving the diseases we fear most. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: Why 80% of Autoimmune Diseases Occur in Women 01:24 Why Dr. Anurag Became an Immunologist 03:19 Immunometabolism: The Link Between Immune Health and Metabolism 04:20 T Cells, B Cells, and the Thymus Gland 05:51 MS and Autoimmune Disease: The T Regulatory Cell Problem 11:32 Mitochondrial Dysfunction and Immune Exhaustion 18:45 Cancer Cells and T Cell Energy Deficit 24:10 Urolithin A: Screening 4000 Pomegranate Compounds 31:20 Mitophagy and Autophagy: Cellular Housekeeping 38:50 NAD+ vs NMN and NR Supplements: What Actually Works 43:15 Creatine Dosing: The 500mg-1g Sweet Spot for Muscle Quality 48:30 Gut-Brain Connection and Neurodegeneration 50:54 Parkinson's Disease and Paraquat: The Mitochondrial Toxin 53:25 AI in Drug Discovery and Next-Generation Molecules 55:38 Skincare and Mitochondrial Health: Collagen Synthesis _______ Thank you to our sponsors KetoneIQ: https://ketone.com/NEURO for 30% OFF Caraway: Carawayhome.com/neuro10 Jones Road Beauty: https://www.jonesroadbeauty.com - Use code NEURO _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

You have more mitochondria in your body than there are stars in the Milky Way, and they determine how energized, focused, and resilient you feel every day. When they're damaged, your “battery” drains fast, no matter how healthy you try to be. In this episode, I'm breaking down the modern energy thieves—and the simple, powerful steps to turn your cellular power back on. Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1 

This week I interviewed Reed Davis for the second time! Reed Davis is a Board Certified Holistic Health Practitioner(HHP) and Certified Nutritional Therapist (CNT), is an expert in functional lab testing and holistic lifestylemedicine. He is the Founder of Functional Diagnostic Nutrition (FDN) and the FDN Certification Course with over 4,000 graduates in 50 countries. We discussed how to avoid environmental toxins, the new food pyramid, Reed's top health principals and his one tip to get your body back to what it once was! Connect with Reed: https://www.functionaldiagnosticnutrition.com/“FDN Methodology in Action” case study series at https://www.fdntraining.com/eatclean26--------How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/FREE Nutrition Cheatsheets:https://brian-getleaneatclean.beehiiv.com/subscribeClick to book a FREE 15 minute consult with Brian:https://calendly.com/bdgryn/15min------------Interested in Upgrading your Mitochondria, Improving Energy and Sleep! Check out Troscriptions: https://bit.ly/4ik5kK5Use Discount Code for 10% OFF: EATCLEAN----Watch Get Lean Eat Clean podcast video episodes on YouTube!YouTube.com/@briangryn3680----B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssV----My favorite health bars with clean ingredients!https://www.eatprima.com/BRIAN6816310% OFF with this link!

In this episode of the How to Hyperbaric Podcast, I'm joined by Dr. Joe Watso, assistant professor at Florida State University and director of the Cardiovascular and Applied Physiology Laboratory.We break down the science of VO2 max, one of the strongest predictors of longevity and overall health. Dr. Watso explains what VO2 max actually measures, why it reflects far more than just fitness, and how it connects to cardiovascular function, lung capacity, mitochondrial health, and long-term independence.We discuss how VO2 max is properly measured in a laboratory setting, how to get an estimate at home, how accurate wearable estimates really are, and how often it makes sense to test it. We also explore how VO2 max compares to heart rate variability (HRV), what lactate threshold and exercise economy reveal about performance, and what markers matter most for longevity and wellness.

In this Huberman Lab Essentials episode, I explore how different wavelengths of light affect the human body and how light exposure can improve sleep quality, mood and daytime alertness while supporting healthy hormone regulation. I also discuss the therapeutic use of ultraviolet and infrared/red light for a wide variety of benefits, including improved skin health and offsetting age-related vision loss. I explain the biological mechanisms behind these light-based therapies and offer practical tools that listeners can use to improve both their mental and physical well-being. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman ROKA: https://roka.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Light (00:00:47) Physics of Light (00:01:57) Light & Body, Rods & Cones, Skin, Seasons & Melatonin (00:05:01) Melatonin Supplements?, Tool: Seasonal Sun Exposure (00:08:32) Sponsor: ROKA (00:09:47) Tool: Melatonin Levels & Reduce Night Light (00:10:31) Light, UVB, Skin Exposure, Testosterone & Estrogen, Fertility (00:13:54) UVB Light & Improved Pain Tolerance (00:16:10) Tool: Daily Sunlight Exposure Protocol; Blue Blockers (00:18:25) Sponsor: AG1 (00:19:16) Seasonal Affective Disorder (SAD), Year-Round Sunlight Exposure (00:21:24) Enhanced Immune Function & UVB Light, Tool: Winter Light Exposure (00:23:45) Light, Wound Healing, Hair & Nail Growth (00:25:11) Tool: Mood, Dopamine & Avoid Nighttime UVB Light (00:27:46) Sponsor: Function (00:29:25) Red Light Therapy, Infrared Light, Acne, Wound Healing & Scars; Mitochondria (00:33:06) Offset Age-Related Eyesight Decline, Red Light (00:37:22) Tool: Red Light Protocol, Frequency & Timing (00:40:02) Red Light for Shift Workers (00:41:42) Recap Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

What if your exhaustion isn't a failure… but a signal that you've reached the ceiling of independence?In this powerful solo episode, Elaine Starling, The Abundance Ambassador, explores why effort eventually stops delivering ease — and how true expansion comes not from pushing harder, but from partnering deeper.You'll discover how your “I AM” declarations shape your identity and lived reality — and why those declarations only become fully effective when paired with Divine partnership through presence, trust, and vulnerability instead of control.Through biology, quantum insight, nervous system awareness, and lived spiritual experience, Elaine reveals how independence builds capability — but partnership unlocks power.This episode is not about fixing yourself.It's about remembering who you truly are.Topics Covered0:00 – The Ceiling of IndependenceWhy capable, high-capacity women reach a point where effort stops creating ease.6:40 – The Power of “I AM” DeclarationsHow identity statements program your nervous system, perception, and energetic field.14:15 – Mitochondria & The Evolutionary Case for PartnershipWhat biology teaches us about collaboration and expansion.22:00 – Vulnerability as a Gateway to PowerWhy releasing control increases capacity.29:30 – Divine Presence Within Every AtomQuantum physics, Elaine's 2005 stroke experience, and embodied unity.36:30 – Coherent Intention vs. Scattered DesireWhy The Divine responds to coherence, not volume.44:00 – Receiving as a Natural StateHow clarity and nervous system alignment create sustainable abundance.50:00 – Invitation to the Monthly Personal Power WorkshopKey Takeaways

Send a text In this episode, Dr. Rodney and Karen Wirth delve into the critical role of mitochondria in overall health and energy production. They emphasize the importance of avoiding harmful seed oils, which can poison cellular processes and contribute to various health issues like fatigue, dementia, and cardiovascular problems. By substituting with healthier oils such as avocado and olive oil, individuals can begin to repair their mitochondrial function. The hosts also highlight the significance of moderate exercise and sleep in maintaining optimal cellular health, encouraging listeners to make small, consistent changes for long-term well-being and vitality. You can't change my mind about seed oils - here's why... podcastFollow us on Instagram.Follow us on Facebook.Visit our website. Please rate us and write a review! 

Dr. Mark Tarnopolsky's VO2 max was once 87.6 ml/kg/min — an elite-level mark few humans have reached. He's competed at three world championships in three different sports. He's also had three cardiac ablation surgeries, bled from his bowels after races, and watched his vision tunnel to a speck crossing a finish line. His story is a master class in where the line falls between peak performance and self-destruction.Now 63, Tarnopolsky is a neurologist, neuromuscular disease specialist, and supplement formulator who has channeled decades of elite athletic experience and hundreds of published studies into the idea that keeping metabolic throughput high is what protects us as we age.In this conversation with Dom D'Agostino, he shares practical strategies anyone can apply: why resistance training three times per week is non-negotiable after 50, why post-exercise nutrient timing improved performance in a simulated training camp with identical calories, why he says creatine belongs in nearly everyone's regimen, and why he personally takes his mitochondrial supplement stack situationally after hard efforts rather than daily.Questions Answered in This Episode:What is the only intervention proven to extend human lifespan — and by how much?At what point does endurance exercise become pro-aging — and what are the warning signs?What simple nutrient timing strategy improved performance with zero extra calories?How did a bodybuilder bar conversation lead to a published discovery about growth hormone and collagen?What muscle and bone costs of Ozempic aren't getting enough attention?Why did elite endurance athletes need nearly as much dietary protein as bodybuilders — and why were bodybuilders massively overconsuming?This conversation reframes the longevity debate around what's actually been proven in human clinical trials — not Petri dishes, not animal models, and not social media influencers.Special thanks to the sponsors of this episode:✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here.✅ Toups and Co – Get 15% off your first order with code METABOLIC here.✅ iRestore – Get a huge discount on the Elite and the Illumina bundle here. ✅ MudWtr – Get up to 43% off + free shipping and a free rechargeable frother with code METABOLICLINK here.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Sponsored By: → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/DRG and save up to 39% off your Mitopure® Gummies. → Puori | Go to https://puori.com/DRG and use the code DRG at checkout to get 32% off your first Puori Creatine+ subscription order. → My one stop shop for quality supplements: https://theswellscore.com/pages/drg Episode Description Your body isn't broken. It's stuck — and there's a very specific reason why. 94% of U.S. adults have some degree of mitochondrial dysfunction. That means the majority of people walking around right now can't make energy efficiently — and they're using caffeine, stimulants, and willpower to paper over it. Dr. Scott Sherr has spent over a decade figuring out why, and more importantly, how to actually fix it. Board-certified in internal medicine and one of the leading voices in health optimization medicine, Dr. Sherr introduces one of the most important concepts Dr. G has heard in a long time: the sympathetic spiral of doom — the feedback loop between chronic stress and mitochondrial breakdown that keeps you wired, exhausted, and unable to heal no matter what you try. In this episode, you'll discover: • Why more caffeine, more supplements, and more biohacks are making the spiral worse — and what to do instead • The GABA system: why depression and anxiety may have nothing to do with serotonin, and everything to do with your brain's brakes failing • The leaky gut → leaky brain connection most doctors have never heard of • How methylene blue works at the mitochondrial level — and why dose and source matter more than you think • What it actually means to optimize your health back to the resilience of your 20s — at any age If you've seen 10 doctors, tried every supplement, and still feel like you can't recover — this episode is the missing piece. Find Dr Sherr: Website: https://www.hyperbaricmedicalsolutions.com/integrative-hbot/scott-sherr Instagram: https://www.instagram.com/drscottsherr  Timestamps: 0:00 - Introduction 0:35 - Rapid Fire Q&A: Caffeine, Methylene Blue & Mitochondria 2:05 - Dr. Scott's Background: From Hospitalist to Health Optimization 8:50 - What Is Health Optimization Medicine? (Ages 21–30 Blueprint) 16:20 - The Sympathetic Spiral of Doom Explained 24:30 - Signs You're Stuck in Fight-or-Flight Mode 33:00 - The GABA System: Why Supplements Don't Cross the Blood-Brain Barrier 43:57 - Methylene Blue Deep Dive: How It Works & Who It's For 51:17 - How to Shop for Methylene Blue (Quality & Dosing Guide) 56:29 - Dr. Scott's Personal Routine for Mitochondria & Nervous System Learn more about your ad choices. Visit megaphone.fm/adchoices

What if your hormone imbalance is not just a hormone problem, but a nervous system and emotional overload problem?  In this episode of The Ben Azadi Show, Ben Azadi welcomes back Dr. Sonya Jensen to explore why so many women feel puffy, inflamed, exhausted, and hormonally off even when labs look “normal.” Dr. Jensen connects inflammation, cortisol, progesterone depletion, estrogen dominance, and liver support with the deeper layers most people miss: stress patterns, identity roles, generational stories, and the constant input from news and social media. They also dive into her new book, Heal Your Hormones, Reclaim Yourself, plus practical tools like breathwork, red light, seasonal whole foods, and gentle nervous system regulation. Key Topics Covered Why hormone symptoms can reflect emotional and relational overload Nervous system dysregulation, cortisol, adrenaline, and progesterone depletion How chronic stress can create a bigger estrogen to progesterone imbalance Why blood work can look normal while you still feel off Urine hormone metabolite testing and what it can reveal about detox pathways Breathwork for lowering cortisol and shifting into rest at night Red light as a nervous system tool, especially in the evening Liver support for inflammation and hormone clearance (milk thistle, turmeric) Calming herbs: ashwagandha, lemon balm (Melissa officinalis), skullcap, ziziphus Whole foods and seasonal eating, including “the season of life” concept Movement without overtraining, including walking and habit stacking HRV as a helpful metric, plus the importance of listening to your body How doom scrolling impacts dopamine, oxytocin, and your sense of safety Mitochondria, maternal stress patterns, and inherited nervous system wiring Dopamine as motivation and joy, and oxytocin as bonding and connection Resources Mentioned Dr. Sonya Jensen Website: https://www.drsonyajensen.com/ Instagram: https://www.instagram.com/drsonyajensen/?hl=en Book Heal Your Hormones, Reclaim Yourself: https://healyourhormonesbook.com Follow Ben Azadi

Have you ever found yourself wondering, “Why am I so tired?”Not just after a long day, but in a way that rest doesn't seem to fix.In this episode, we explore fatigue and low energy through a different lens. Where the body is not broken, but communicating to you. I'm joined by Dr. Evan Hirsch, creator of the Energy MD Method, to talk about what shifting energy levels may be trying to tell us. We explore how fatigue is shaped not just by the physical body, but by the nervous system, stress patterns, beliefs, and the way we relate to ourselves, and why supporting all of these layers is often what allows energy to return.This conversation is an invitation to stop pushing, start listening, and understand what deeper support your body may be asking for.In this episode, we explore:The difference between temporary tiredness and deeper energy depletionWhy rest alone doesn't always restore energyHow stress, trauma, and nervous system dysregulation impact fatigueLong COVID, chronic fatigue patterns, and why exercise can sometimes backfireWhy lab testing can miss key contributors to low energyMindset and nervous system tools that support healing (gratitude, beliefs, visualization, somatic practices)Foundational lifestyle supports for rebuilding energy gently00:00 Fatigue as a Wake-Up Call (Podcast Intro)01:38 Acute vs. Chronic Fatigue: What's Normal?04:29 Evan Hirsch's Personal Story & Why He Focuses on Energy07:47 Chronic Fatigue Syndrome Explained + The “Toxic Five” Root Causes09:25 Long COVID vs CFS: Spike Protein, Mitochondria & Exercise Crashes13:47 How Long COVID Is Diagnosed + Symptom Patterns16:46 Why Lab Tests Miss Toxins: Treating Causes Without Chasing Results22:06 Stress, Nervous System Retraining & The Toxic Burden Matrix25:24 Nervous System Dysfunction: The Missing Link in Chronic Fatigue26:08 Trauma, Beliefs & Survival Patterns That Keep the Body Stuck28:19 From Hustle to Burnout: How Stress Drains Energy Over Time30:05 Food Cravings, Self-Worth & Regulation: Why Depletion Drives Choices32:49 Feeling Safe in Your Body: Gratitude, Beliefs, Vision & Empowering Questions36:26 Top-Down vs Bottom-Up Tools: Polyvagal Practices & Somatic Regulation38:56 When to Get Help: Key Symptoms of Long COVID/Chronic Fatigue40:37 Lifestyle Foundations Checklist: Sleep, Water, Food & Goldilocks Movement45:21 Free Masterclass + Where to Follow (Final Thoughts)Evan H. Hirsch, MD, is a world-renowned chronic fatigue expert, best-selling author, and professional speaker. He is the creator of the EnergyMD Method, the science-backed, clinically proven 4-step process for resolving chronic fatigue and related symptoms from long COVID and Chronic Fatigue Syndome (ME/CFS) naturally. Free Masterclass: Discover the 4-Step System That Helped Me Beat Chronic Fatigue Syndrome so You Can Wake Up Feeling Refreshed and Enjoy Every Moment With Your Kids and Grandkidshttps://www.energymdmethod.com/masterclass-registrationhttps://www.energymdmethod.com/www.instagram.com/evanhirschmd/ www.youtube.com/c/EvanHHirschMD www.tiktok.com/@energymdReclaiming Your Power With Food: MasteringMindfulness.Institute/FreeTrainingwww.instagram.com/gina.worful#tired #energy #chronicfatigue #longcovid

In this episode of the Evolving Wellness Podcast, host Sarah Kleiner welcomes back Dr. Scott to discuss the 'sympathetic spiral of doom' and how modern lifestyles contribute to chronic stress and energy depletion. Dr. Scott shares insights into how overstimulation, poor diet, and interrupted sleep cycles can lead to nervous system dysregulation and mitochondrial dysfunction. The conversation covers the importance of circadian rhythm, hydration, and low-hanging fruit lifestyle changes to support overall wellbeing. They also explore the potential benefits of methylene blue, red light therapy, and other practical tools for regaining optimal health. Tune in to learn more about foundational steps to improve energy levels and break free from chronic stress.About Dr. ScottDr. Scott Sherr is a Board-Certified Internal Medicine Physician Certified to Practice Health Optimization Medicine (HOMe), a specialist in Hyperbaric Oxygen Therapy (HBOT), and COO of Troscriptions (a Smarter Not Harder company). His clinical telepractice includes HOMe as its foundation alongside an integrative approach to HBOT that includes cutting edge and dynamic HBOT protocols, comprehensive testing (using the HOMe framework), targeted supplementation, personal practices, synergistic technologies (new, ancient, psychedelic), and moreConnect with Dr. Scott - https://www.linkedin.com/in/drsherr/ _________Sponsored By:→ Bon Charge | Go to https://boncharge.com/products/demi-red-light-device?rfsn=8108115.26608d & use code SARAHKLEINER for 15% off storewide.→ VivaRays | This episode is sponsored by VivaRays - VivaRays Blue - code YOGI https://vivarays.com/ → Organifi | For an exclusive offer, go to https://www.organifi.com/SARAHK for 20% off your order._________Timestamp:00:00 Introduction and Personal Experience with Coffee00:51 Welcome to the Evolving Wellness Podcast03:37 Understanding the Sympathetic Spiral of Doom06:29 The Role of the Nervous System and Mitochondria10:53 Practical Tips for Nervous System Regulation16:53 The Importance of Circadian Rhythm and Light Exposure25:31 Supporting Mitochondrial Health and Energy Production36:17 The State of Metabolic Health in the US36:55 Improving Mitochondrial Function37:27 Addressing Trauma and Sympathetic Overdrive38:31 The Importance of a Supportive Environment40:38 Sleep and Its Impact on Health44:35 The Role of Blue Blockers and Sleep Aids48:21 Caffeine and Its Effects on the Body50:46 The Benefits of Exogenous Ketones58:56 Navigating the Sympathetic Spiral of Doom01:05:14 Final Thoughts and Resources——— This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!________________________________________Get all my free guides and product recommendations to get started on your journey!https://www.sarahkleinerwellness.com/all-free-resourcesCheck out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) -  https://www.sarahkleinerwellness.com/coursesMy free product guide with all product recommendations and discount codes:https://www.canva.com/design/DAF7mlgZpJI/xVyE4tiQFEWJmh_Xwx8Kbw/view?utm_content=DAF7mlgZpJIFree Webinar on Light & Health (includes free light bulb guide) - https://www.sarahkleinerwellness.com/mycircadianapp-free-webinarGet Early Access to Podcast Episodes & my Seasonal Food Course + UVB+Red Light Therapy course for free -  https://open.substack.com/pub/sarahkleinerwellness/p/uvbred-light-protocol?r=5eztl9&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Ramona is a neuroscientist and scientific strategist with deep experience at the intersection of neuroscience, rehabilitation, and emerging health technologies. She earned her BS in Psychology from Brown University, her PhD in Neuroscience from the Uniformed Services University (where her research focused on the modulation of inflammation following Neurotrauma, including publications on the impact of photobiomodulation on microglial activation), and she completed a postdoctoral fellowship in the Neurology Department at the University of Texas at Austin Dell Medical School.Ramona is the Senior Director of US Medical Affairs for Winback America, and serves as a Scientific Advisor for two start ups, Neuronic and the Brainnovation Network. She specializes in translating complex science into real-world clinical and commercial outcomes — from leading research and publication efforts to building clinician training programs. In these roles, she oversees clinical research, education, and regulatory positioning. At Neuronic specifically, she supports research efforts to demonstrate the efficacy of transcranial photobiomodulation on cognitive function and a variety of neurological conditions.She is passionate about leveraging technology to help people achieve their highest quality of life and brings a practical, collaborative approach to connecting science, clinical practice, and business strategy. SHOWNOTES:

What if your breakthrough isn't another supplement or hormone protocol, but a personalized understanding of what's actually driving your results?In this episode of the Smart Nutrition Made Simple Show, I talk with Brad Clifford, founder and CEO of ELEVÉTION Health, a concierge performance company built around genomics, advanced blood work, and cellular health. Brad shares how he went from panic attacks and brain fog to rebuilding his health from the cellular level up.We break down the two-pronged nature of health, psychological and physiological, why sleep is the ultimate force multiplier, and why no supplement, peptide, or TRT protocol can replace foundational habits. We also dive into metabolic flexibility, mitochondrial health, GLP-1 drugs, and why most people regain the weight when they come off them.Tune in now to build a smarter, more sustainable strategy for long-term performance and longevity.Timestamps:00:00 – Why GLP-1 Drugs Feel So Powerful 01:44 – Episode Intro 03:26 – Who Is Brad Clifford? 07:03 – The Two Prongs of Health 08:25 – Sleep, Nutrition & Exercise Foundations 12:25 – Brad's Health Struggles & Panic Attacks 15:30 – Genomics & Brain Chemistry 21:44 – How Elevation Differs from Typical Clinics 24:41 – Why “Stacks” Don't Work 28:30 – Mitochondria & NAD 31:51 – Metabolic Flexibility 34:52 – Carnivore & Long-Term Tradeoffs 39:27 – Addition by Subtraction 40:00 – Sleep & Injury Risk 41:30 – Psychology of Transformation 43:00 – GLP-1 Weight Regain 46:17 – Future Casting & Identity 51:05 – UK Expansion 52:01 – Where to ConnectConnect with Brad CliffordWebsite: https://www.elevetion.comInstagram (Elevation): https://www.instagram.com/elevetionhealth/Instagram (Brad): https://www.instagram.com/brad_cliffordLinks & Resources:Connect with Ben on Instagram: https://www.instagram.com/bodysystemscoaching/Learn more about Ben's coaching program: www.bodysystems.comSubscribe to the Smart Nutrition Made Simple Show on Apple Podcasts -

Send a textIn episode #174 we discussed Dr. Jose Areta's latest research, including:How energy deficits influence muscle protein synthesis and qualityThe role of mitochondrial proteins and their upregulation during energy restrictionPractical implications for timing and periodization of caloric deficits in training cyclesHormonal signals and their interaction with muscle adaptation during energy deficitsAssociate Professor Dr. José L. Areta is a leading scholar in Exercise Metabolism and Nutrition in the School of Sport and Exercise Sciences at Liverpool John Moores University (LJMU). His research investigates how nutrition and exercise interact to influence both performance and health. He focuses on the timing and composition of macronutrients — carbohydrates, proteins, and fats — and how they affect training adaptation. José also examines the role of dietary supplements in optimizing athletic performance, as well as the endocrine and metabolic consequences of energy restriction, particularly low energy availability. He has contributed influential studies on how severe calorie deficits combined with exercise can alter muscle quality and metabolism. José's work links cellular-level changes in muscle to practical nutrition strategies for athletes facing weight-sensitive sports or energy restriction.Please note that this podcast is created strictly for educational purposes and should never be used for medical diagnosis or treatment.Follow Jose Areta's research: Study discussed, Endocrine, Metabolic, and Skeletal Muscle Proteomic Responses During Energy Deficit With Concomitant Aerobic Exercise in Humans: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502384RRIG: https://www.instagram.com/jose_l_aretaWeb: https://profiles.ljmu.ac.uk/13460-jose-aretaResearch: https://scholar.google.com/citations?user=8tP0vzUAAAAJ&hl=enMentioned:A Systematic Review and Meta-Analysis on the Association and Differences between Aerobic Threshold and Pint of Optimal Fat OxidationCreatineBeta-alanineMORE NR Save 10% on our website with code NEWPOD10 Apply to work with us, click here: https://nutritional-revolution.com/ Interested in having your biomarkers or nutrigenomics checked? Email us at nutritionalrev@gmail.com Follow us @nutritionalrevolution Save 20% on supplements at our trusted online source: https://us.fullscript.com/welcome/kchannell Join Nutritional Revolution's The Feed Club to get $20 off with an additional $20 Feed credit drop every 90 days.: https://thefeed.com/teams/nutritional-revolution If you're interested in sponsoring Nutritional Revolution Podcast, shoot us an email at nutritionalrev@gmail.com.

This week I interviewed the king of the mattress - Derek Hales! Since 2013, Derek has tested over 500 mattresses and founded NapLab, a platform that takes a truly data-driven approach to sleep products. His methodology goes far beyond surface impressions; instead, every mattress is subjected to 10 standardized tests with 43 measurable data points, so people can learn how cooling, motion isolation, and edge support actually impact their sleep and health. We discuss the importance of the weight of your mattress is along with:  - What is the best mattress to maintain your cool throughout the night- Is memory foam worth the hype?- Should you rotate your mattressand much, much more!!Connect with Derek:https://naplab.com/-----------------How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/FREE Nutrition Cheatsheets:https://brian-getleaneatclean.beehiiv.com/subscribeClick to book a FREE 15 minute consult with Brian:https://calendly.com/bdgryn/15min------------Interested in Upgrading your Mitochondria, Improving Energy and Sleep! Check out Troscriptions: https://bit.ly/4ik5kK5Use Discount Code for 10% OFF: EATCLEAN----Watch Get Lean Eat Clean podcast video episodes on YouTube!YouTube.com/@briangryn3680----B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssV----My favorite health bars with clean ingredients!https://www.eatprima.com/BRIAN6816310% OFF with this link!

Angela talks to Ari Whitten, the founder of The Energy Blueprint and an expert in mitochondrial health about his comprehensive approach to overcoming fatigue and optimising energy levels by addressing the cellular engines of the body—the mitochondria.  Ari explains how modern lifestyle factors, such as poor light exposure, chronic stress, and nutritional deficiencies, signal the mitochondria to enter a defence mode rather than an energy-producing mode WHAT YOU'LL LEARN: The Cell Danger Response (CDR): Mitochondria have a dual role; they are not just energy producers but also environmental sensors that shift into a defensive state when they perceive threats Circadian Rhythm and Light: Proper exposure to natural light in the morning and minimising artificial blue light at night is critical for regulating the mitochondrial clock and ensuring deep, restorative sleep. Hormetic Stress: Introducing controlled stressors—such as high-intensity exercise, cold exposure, or heat—can actually strengthen mitochondria and increase their capacity to produce energy The Importance of Nutrient Density: Specific nutrients, including CoQ10, magnesium, and polyphenols, are essential "fuel" for the electron transport chain TIMESTAMPS [00:04:15] The "Energy Gap" [00:18:30] Mitochondria as Sensors [00:32:45] The Power of Red Light Therapy [00:52:10] Building Metabolic Flexibility VALUABLE RESOURCES ⁠Join The High Performance Health Community⁠ ⁠Click here⁠ for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible The Ultimate Guide to Red Light Therapy  Find out your biological age and how your daily habits are influencing it with DNA, bloodwork and microbiome testing with a Stride One membership - visit https://www.getstride.com/angela/ for 10% off. Ready to support your body at the cellular level where it matters? Head to www.MitoQ.com and use my code ANGELA for 10% off your first order *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. CONTACT DETAILS ⁠Instagram⁠ ⁠Facebook⁠ ⁠LinkedIn⁠ Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast. This Podcast has been brought to you by Disruptive Media. ⁠https://disruptivemedia.co.uk/

Send a textThe biology of fat tissue, estrogen's role in metabolism and health, and how exercise interacts with these processes, especially during menopause.TOPICS DISCUSSED:Adipose tissue basics: White fat primarily stores energy in large lipid droplets, while brown fat burns fatty acids for heat via high mitochondrial density; white fat can “brown” with exercise or certain foods like capsaicin.Fat distribution & health: Subcutaneous fat (under skin) is more insulin-sensitive and less problematic than visceral fat (around organs), which links to metabolic issues; females store more subcutaneously pre-menopause, shifting to visceral post-menopause.Estrogen signaling: Estradiol binds nuclear and membrane receptors to regulate gene expression and mitochondrial function; it enhances insulin sensitivity and browning in fat cells, with receptors like ER-alpha feminizing fat distribution.Fat storage: Fat cells enlarge (hypertrophy) more than multiply in obesity, leading to hypoxia, inflammation, and insulin resistance; excess fatty acids spill to liver and muscle, worsening metabolic dysfunction.Menopause effects: Estrogen drop causes visceral fat gain, reduced energy expenditure, insulin resistance, and higher metabolic disease risk; symptoms include hot flashes and reduced exercise motivation, modeled in rodents via ovary removal.Exercise & estrogen links: Exercise boosts estrogen receptor expression and mitochondrial density in fat, mimicking estrogen's browning effects; synergism may explain reduced exercise responsiveness post-menopause.Brain-fat connections: Estrogen in the nucleus accumbens influences exercise motivation and fat browning; manipulations there alter running behavior and adipose metabolism in rodents.ABOUT THE GUEST: Victoria Vieira-Potter, PhD leads a lab at the University of Missouri, studying how estrogen and exercise influence adipose cells.RELATED EPISODE:M&M 174 | Adipose Tissue & Body Fat: Obesity, Insulin, Leptin, Fertility, Weight Loss & GLP-1 Drugs | Sean HartigSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Today's conversation dives deep into hormone health and the myths surrounding testosterone therapy, featuring Shalin Shah, CEO of Marius Pharmaceuticals, and guided by host Chris Duffin with contributions from Anthony, our co-host. We'll explore the stigmas and misconceptions attached to testosterone treatments, the groundbreaking launch of Kaisertrex (an FDA-approved oral testosterone capsule), and why hormone diagnostics matter for both men and women. Shalin Shah shares his journey as a passionate advocate for gender equity in hormone care and discusses how lifestyle, environmental factors, and stress impact hormone levels—especially as more young people experience low testosterone.  

In this episode, I sit down with Daria Mochly-Rosen to explore the powerful role mitochondria play in our energy, brain health, metabolism, and long term resilience. We talk about the science behind sleep, strength training, stress, and nutrition, and how simple daily habits can support better healthspan without falling into burnout or extreme biohacks.We also cover the cultural pressure to hustle nonstop, why slowing down is not a weakness, and how connection, family, and meaningful conversations can actually support your biology. She breaks down the fascinating truth about how we inherit mitochondria, how lifestyle choices influence cellular health, and why it is never too late to start building stronger, more resilient energy from the inside out.→ Leave Us A Voice Message! Topics Discussed:→ What are mitochondria?→ How to boost energy?→ Does sleep affect health?→ Best habits for longevity?→ Are mitochondria inherited?Sponsored By: → Function | Own your health for $365 a year. That's a dollar a day. Learn more and join using my link. Visit https://www.functionhealth.com/bewellbykelly and use gift code BEWELL25 for a $25 credit toward your membership→ Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com.→ Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/KELLY and save up to 39% off your Mitopure® Gummies.→ Fatty 15 | Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. You can get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/KELLY15 and using code KELLY15 at checkout.Timestamps: → 00:00:00 - Introduction→ 00:01:57 - What are mitochondria?→ 00:02:48 - Mitochondria in each cell→ 00:03:46 - Krebs cycle, ATP + metabolism→ 00:06:24 - Cellular energy production→ 00:08:22 - Nutrition for energy→ 00:14:08 - Healthy vs refined carbs→ 00:17:05 - Sugar + metabolic health→ 00:19:12 - Fad diets explained→ 00:23:45 - Lifestyle changes for longevity→ 00:30:33 - Stress + mitochondrial health→ 00:35:59 - Mitophagy + autophagy benefits→ 00:40:46 - Glymphatic brain detox→ 00:43:09 - Exercise + movement science→ 00:49:10 - Mitochondrial peptides→ 00:55:16 - MOTS-C peptide benefits→ 00:56:35 - Chronic disease + mitochondria→ 01:02:38 - Reactive oxygen species→ 01:07:36 - Family, connection + health→ 01:12:07 - Fertility + energy health→ 01:15:01 - Building healthy mitochondriaFurther Listening: → The Key to Longevity: Exploring Mitochondrial Uncoupling with Dr. Steven GundryCheck Out Daria:→ Stanford | https://med.stanford.edu/profiles/daria-mochly-rosen→ Linkedin | https://www.linkedin.com/in/daria-mochly-rosen-9733bb198→ Book |

This episode is brought to you by Troscriptions and Strong Coffee Company. What if the smallest molecule in the universe could have the biggest impact on your health? Welcome "Greg the Hydrogen Man" to explore the science, controversy, and real-world application of hydrogen water and molecular hydrogen therapy. This conversation goes beyond hydration — it explores how hydrogen acts as a biological signal, how it interacts with oxygen, and why it may be foundational to cellular health. Whether you're into biohacking, longevity, performance, or holistic health, this episode will challenge how you think about water and what it means to truly nourish the body. ----- 00:00 – Why water can heal… or harm 02:30 – Why most hydrogen devices are problematic 05:00 – Japan's longevity advantage explained 07:45 – Hydrogen, gut health, and gas signaling 10:00 – What hydrogen water actually is 14:00 – The healing waters of Lourdes & hydrogen discovery 17:30 – Why hydrogen is different from all antioxidants 19:30 – Mitochondria, oxidative stress & disease 22:45 – Hydrogen and stroke recovery in Japan 26:30 – Why clean water matters before hydrogen 30:00 – Live blood analysis: clean water vs hydrogen water 33:30 – How hydrogen acts as a cellular signal 36:00 – Morning hydrogen water protocol 40:30 – The Japanese hydrogen machine origin story 43:00 – How long before people feel results 45:30 – Safety, medications & contraindications 48:30 –Ever Forward ----- Episode resources: Try Calm by Troscriptions and use checkout code EVERFORWARD Save 15% on organic coffee and lattes with code CHASE at https://www.StrongCoffeeCompany.com Watch and subscribe on YouTube Greg's YouTube channel

Dr. Catherine Clinton shares her journey into the growing field of quantum biology that led to her book, Optimize, that explains how light, water, sound and human energy influence the human body at the cellular level, this week on Spirit Gym.Learn more about Catherine's work on her website. Find her on social media via Facebook, Instagram and YouTube.Order Catherine's book, Optimize, and receive more than $400 in free bonuses, including her Quantum Biology Masterclass and her Unlocking Your Quantum Biology course at this link.Timestamps6:51 Catherine's introduction to natural medicine.10:48 Psychoneuroimmunology.19:25 Quantum biology: Waves that hold energy and information.27:21 The electrical capacity of the human body and how pain emerges.34:19 pH balance and a positive charge in the body.48:04 What is the source of electrical currents in nature and humans?57:08 The fascia as a liquid crystalline semiconductor that can create its own charge.1:08:39 When Catherine went all in on quantum biology.1:15:59 Nurturing a relationship with the natural world is one of the most overlooked ways to elevate our health.1:26:17 “We don't end at the barriers of our skin.”1:32:32 Tantra and the Nada Bindu point.1:41:07 The physical receiver.1:47:08 “Use your heart to feel what you know.”1:53:26 Water: The bridge for frequency information.2:03:16 “Awe is medicine.”2:11:04 Digging deeper into the mitochondria.2:27:47 Did you know each of us can communicate with the universe via infrared light transmission?ResourcesWhat is Life? by Erwin SchrodingerWater, The Cradle of Life via its Coherent Quantum Frequencies by Hans Geesink, Dirk Mejier and Igor Jerman (free PDF)Adenosine triphosphate (ATP)Electric Body, Electric Health by Eileen McKusickFind more resources for this episode on our website.Music Credit: Meet Your Heroes (444Hz), Composed, mixed, mastered and produced by Michael RB Schwartz of Brave Bear MusicThanks to our awesome sponsors:PaleovalleyBIOptimizers US and BIOptimizers UK PAUL15Organifi CHEK20Wild PasturesKorrect SPIRITGYMPique LifeCHEK Institute We may earn commissions from qualifying purchases using affiliate links.

In the late 1990s, a strange carbon molecule quietly delivered the single longest lifespan extension ever recorded in mammals. The rats lived about 90% longer, and almost no one was paying attention. This episode breaks down what that molecule is, why it works, and how it may upgrade mitochondria, sleep, and human performance when used correctly. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Chris Burres, founder and chief scientist of MyVitalC and the original long-term manufacturer of carbon 60. Chris has produced this Nobel Prize–winning molecule since the early 1990s, supplying research institutions around the world years before it ever entered the biohacking space. He explains how carbon 60 behaves differently from traditional antioxidants, why stability and concentration used to be major problems, and how modern manufacturing finally made real-world use possible. Chris is also a published author, longevity summit host, patent holder, and longtime science communicator who brings rare clarity and humor to complex biology. Dave and Chris explore how carbon 60 interacts with mitochondria, oxidative stress, metabolism, and electrical signaling in the body, and where it fits alongside ketosis, nootropics, supplements, and functional medicine strategies. They also unpack why improving mitochondrial function often shows up first as better energy and sleep optimization, and how that foundation supports longevity, brain optimization, and Smarter Not Harder performance. Along the way, Dave shares his own early experience with C60, how he uses it today, and why it now shows up even in his Danger Coffee stack. You'll Learn: • Why carbon 60 produced the longest longevity result ever recorded in mammal studies • How mitochondrial efficiency shapes energy, sleep, and human performance • What makes C60 a selective antioxidant instead of a blunt one • Why purity, concentration, and stability determine whether a supplement works • How carbon 60 fits into biohacking stacks built around ketosis and metabolism • What users report first, from focus and resilience to deeper sleep • Why mitochondrial health underpins long-term anti-aging strategies • How to think about supplements through a Smarter Not Harder lens Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Affiliates: Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: carbon 60 podcast, C60 longevity science, biohacking mitochondria, mitochondrial optimization podcast, anti-aging supplements science, human performance longevity, selective antioxidant mitochondria, sleep optimization biohacking, brain optimization supplements, nootropics longevity stack, ketosis metabolism longevity, functional medicine mitochondria, oxidative stress longevity, carbon 60 supplement science, MyVitalC podcast, Chris Burres interview, Dave Asprey biohacking, Danger Coffee stack, Smarter Not Harder longevity, Nobel Prize molecule longevity, mitochondrial health podcast Resources: • Get a 30% discount on your next purchase of ESS60 at: https://www.myvitalc.com/pages/humanupgradeod?ref=humanupgrade • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Introduction & C60 Discovery 4:04 – The Molecule & Nobel Prize 8:27 – Quantum Properties & Superconductivity 11:16 – Rat Longevity Study Results 14:33 – Selective Antioxidant Properties 15:51 – User Experience & Timeline 18:15 – Biological Age Testing 21:33 – Why Oil & Product Development 23:32 – Mechanism of Action 28:13 – Biohacker Discovery Story 30:03 – FDA & Supplement Regulation 33:50 – Migraines & Clinical Observations 37:53 – Athletic Performance 40:43 – Stacking & Contraindications 45:57 – Skincare Product 50:43 – Who Benefits Most 1:00:37 – Mitochondria & Consciousness 1:02:03 – Where to Buy & Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your butt is not about aesthetics. It is a longevity organ that directly impacts metabolism, brain optimization, resilience, and how long you stay strong as you age. In this episode, you'll learn why strength training and protein intake matter more than body fat percentage, how mitochondria drive human performance and recovery, and why building muscle protects your brain, stabilizes mood, and supports long-term longevity. This conversation reframes biohacking, anti-aging, and health from weight loss to muscle span, the length of time you live with strong, functional skeletal muscle. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Gabrielle Lyon, an accomplished physician and New York Times bestselling author of Forever Strong: A New, Science-Based Strategy for Aging Well, and author of the upcoming The Forever Strong Playbook, releasing January 27, 2026. Dr. Lyon pioneered the Muscle-Centric Medicine® approach, which places muscle at the center of disease prevention, metabolic health, and true vitality. She has trained elite athletes, military operatives, and public figures, while also living this philosophy at home as a mother of two with her husband, a retired Navy SEAL. Together, they break down why intermuscular fat may matter more than body fat percentage, how skeletal muscle drives insulin sensitivity and lowers inflammation, and why becoming physically stronger improves brain function and neuroplasticity. They explore protein needs across the lifespan, fasting, ketosis, carnivore-style nutrition, supplements, sleep optimization, and the real tradeoffs of GLP-1 drugs, including the risk of accelerated muscle loss if strength and protein are neglected. The conversation also covers mindset, hormesis, and why physical resilience creates emotional regulation and clearer decision-making in a world increasingly shaped by AI and convenience. This episode is essential listening for anyone serious about biohacking, hacking human performance, longevity, mitochondria, neuroplasticity, nootropics, metabolism, functional medicine, anti-aging strategies, supplements, and living Smarter Not Harder, ideally with a cup of Danger Coffee in hand. You'll Learn: • Why your glutes and skeletal muscle are critical drivers of longevity and brain health • Why intermuscular fat can matter more than body fat percentage for metabolic dysfunction • How strength training improves neuroplasticity, cognition, and emotional resilience • Why protein needs increase with age and why outdated limits can hold you back • What GLP-1 drugs get right, where they fail, and how to protect muscle span • Why progressive stimulus beats lifting heavy for long-term strength and injury prevention • How sleep optimization and recovery support mitochondria and human performance • How building muscle creates clarity, resilience, and better decision-making Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! Quantum Upgrade | Support your brain, energy, focus, sleep, and recovery with Quantum Upgrade, a 24/7 streaming quantum energy service designed to work continuously in the background. Try it free for 15 days with no credit card required: https://quantumupgrade.io/DAVE Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. KillSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com and use code DAVE for 20% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: muscle longevity organ, glutes brain health, strength training longevity podcast, muscle span aging, intermuscular fat metabolism, IMAT insulin resistance, skeletal muscle brain function, neuroplasticity strength training, protein intake aging, high protein diet longevity, metabolism muscle health, mitochondria muscle brain, muscle centric medicine podcast, gabrielle lyon podcast, forever strong playbook, women strength training longevity, GLP-1 muscle loss, sarcopenia aging prevention, resistance training brain health, sleep optimization muscle recovery, fasting ketosis muscle health, carnivore diet muscle metabolism, functional medicine muscle health, biohacking strength longevity, human performance muscle, anti-aging strength training, supplements muscle recovery, progressive stimulus training, blood flow restriction training, muscle resilience mindset Resources: • Get Gabrielle's NEW book Forever Strong: https://drgabriellelyon.com/forever-strong/ • Gabrielle's Website: https://drgabriellelyon.com/ • Follow Gabrielle's Instagram: https://www.instagram.com/drgabriellelyon/ • Gabrielles Youtube: https://www.youtube.com/@DrGabrielleLyon • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Introduction 1:01 – The Playbook vs Workbook 3:47 – Protein & Metabolic Health 6:21 – Mindset & Negativity 7:20 – Histamines & Hot Flashes 10:49 – Women & Strength Training 13:40 – Connective Tissue & EDS 16:15 – Muscle Span & Aging 19:41 – Training for Kids 21:55 – Pain Cave & Discomfort 25:25 – Emotional Regulation 29:46 – Resilience & Dating 32:11 – Building Friction & Discernment 35:47 – Self-Denial vs Awareness 41:03 – Mitochondria & Energy 42:46 – Bigger Booty, Bigger Brain 44:52 – Body Fat vs IMAT 49:01 – Measuring Muscle Health 52:08 – GLP-1s & Muscle Loss 56:12 – Protein Absorption Myths 59:30 – mTOR & Protein 1:01:29 – Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dorian Yates is a former professional bodybuilder, six-time Mr. Olympia winner and a pioneer of high-intensity, low-volume training for building muscle size and strength. He explains how anyone can vastly improve their fitness, mindset and appearance by training with weights just two or three days per week for less than an hour. We also discuss how to determine your natural strengths and passions and select which life path is right for you. Dorian also shares his journey and transformation from wayward youth to world champion athlete, his exploration of psychedelics, views on cannabis and on longevity and health optimization more generally. The knowledge and wisdom Dorian shares is valuable to men and women of all ages. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David Protein: https://davidprotein.com/huberman Joovv: https://joovv.com/huberman Our Place: https://fromourplace.com/huberman LMNT: https://drinklmnt.com/huberman Function Health: https://functionhealth.com/huberman Timestamps (00:00:00) Dorian Yates (00:03:17) High-Intensity Training, Bodybuilding, Blood & Guts (00:09:15) Muscular Failure, Stimulate & Recover; Anabolics (00:12:04) Sponsors: David & Joovv (00:14:33) Muscle Pump, Stimulus; Recovery Weeks (00:17:32) Beginners & Learning Correct Mechanics; Diabetes (00:22:13) Research vs Real World, Tool: High-Intensity, Low-Volume Training, HIIT Sprints (00:28:53) Bodybuilding Journey, Reading, Training Logs, Aspiration, Parents (00:39:21) Sponsors: AG1 & Our Place (00:42:46) TRT, Steroids, Genetics, Early Bodybuilding Career; Tool: Steroid Risks (00:53:57) Father & Son Relationship; Training Evolution (00:58:31) Workout Intensity & Motivation, Self-Mastery, Transforming Anger (01:05:34) Death; Opportunity Analysis; Bodybuilders, Steroids & Diuretics (01:12:18) Human Possibility, Fitness & Health Progression, Nutrition (01:16:05) Sponsor: LMNT (01:17:26) Mike Mentzer (01:20:42) 1992-1993 Mr. Olympia, Underdog vs Favorite Mindset (01:30:22) Inspiration & Achieving Goal; Retirement, Transition & Identity (01:38:52) Flexibility, Winning vs Loving the Process (01:43:08) Aging, Exercise & Posture (01:46:34) Sponsor: Function (01:48:22) Losing Muscle & Diet Change; Breathing; Health & Mind (01:52:02) Psychedelics, DMT, Ayahuasca, Perspective & Connection (02:01:20) Risks, Research & Psychedelics; Brain Plasticity, Perspective Change (02:06:23) Sunlight & Mood, Schizophrenia, Dopamine, Mitochondria (02:12:15) Cannabis, Smoking & Health; Cancer; Breathwork (02:19:34) Cannabis & Motivation, Individual Variation, THC Levels (02:25:22) Plant Medicine, Kratom, Natural Plants vs Extracts (02:28:53) Training for Women, Losing Fat & Resistance Training; Resilience (02:33:52) DY Nutrition, Supplements; Life Purpose & Consciousness (02:44:40) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices