Podcasts about WNT

BUFFALO, NY – August 11, 2025 – A new #researchpaper was #published in Volume 16 of Oncotarget on July 25, 2025, titled “Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer.” In this study, researchers led by first author Aiden Deacon and corresponding author Justin Hwang from the University of Minnesota-Twin Cities investigated a group of genes known as the R-spondin family (RSPO1/2/3/4) in advanced prostate cancer (PC). The RSPO gene family regulates Wnt signaling, a pathway involved in cancer progression. Prostate cancer is the most common cancer among men in the United States and becomes especially dangerous when it spreads beyond the prostate. Most patients are treated with hormone therapies that target the androgen receptor; however, many tumors eventually become resistant. The research team analyzed thousands of tumor samples and found that RSPO2 alterations were more common than changes in other R-spondin genes or even some well-known cancer-related genes like CTNNB1 and APC. RSPO2 amplification occurred in over 20% of metastatic prostate cancer. Patients with these alterations showed signs of more aggressive disease, including higher mutation rates and greater tumor complexity. Using laboratory models, the team discovered that RSPO2 increases cancer cell growth and triggers a biological process called epithelial-mesenchymal transition (EMT). EMT is known to promote tumor spread and resistance to standard treatments. Unlike other genes in the same pathway, RSPO2 also appeared to reduce the activity of androgen receptor genes, suggesting it drives a type of prostate cancer that no longer relies on hormones for growth. “In cell lines, RSPO2 overexpression caused up-regulation of EMT pathways, including EMT-regulatory transcription factors ZEB1, ZEB2, and TWIST1.” Importantly, RSPO2 showed structural differences from other R-spondin proteins, which may allow researchers to design drugs that specifically block its activity. Current therapies targeting the Wnt pathway are limited, and there are no approved drugs that inhibit RSPO2. However, this study highlights RSPO2 as a promising therapeutic target, especially for patients who do not respond to existing hormone-based treatments. This research adds critical knowledge about how aggressive prostate cancers develop and persist despite therapy. The identification of RSPO2 as a key driver of disease progression opens new possibilities for treatment strategies aimed at improving outcomes for patients with advanced prostate cancer. DOI - https://doi.org/10.18632/oncotarget.28758 Correspondence to - Justin Hwang - jhwang@umn.edu Video short - https://www.youtube.com/watch?v=iyu5D_c1dbY Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28758 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, RSPO2, prostate cancer, Wnt signaling, genomics, therapeutics To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY – July 22, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 21, 2025, titled “Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer.” In this work, led by first author Sneha Tripathi from the Indian Institute of Science Education and Research and corresponding author Sanjeev Galande from the Center of Excellence in Epigenetics at Shiv Nadar University, researchers discovered that statins, widely used to lower cholesterol, may also suppress colorectal cancer growth. This finding highlights a potential new role for these common drugs in cancer prevention and therapy. Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, and new strategies are urgently needed to improve treatment results. Statins, originally developed to lower cholesterol levels, have gained attention for their possible anti-cancer properties. The study investigated how statins affect the Wnt/β-catenin signaling pathway, a critical driver in colorectal cancer development and progression. The researchers discovered that statins disrupt the Wnt/β-catenin signaling pathway, leading to lower levels of tumor-promoting proteins and to cancer-suppressing cellular behaviors. Experiments in both colorectal cell cultures and mouse models confirmed that statins reduced tumor growth without causing noticeable side effects. This study further revealed that statins downregulate SATB1, a protein linked to aggressive tumor behavior, while increasing SATB2, a protein with tumor-suppressing effects. These changes made the cancer cells less able to grow and spread. “This reciprocal regulation shifts cellular phenotypes between epithelial and mesenchymal states in 3D spheroid models.” Overall, the findings suggest that statins could be repurposed to complement existing colorectal cancer treatments or even be used in preventive strategies for high-risk individuals. By targeting the molecular machinery that drives colorectal tumor development, statins offer a promising, accessible, and well-understood option for further research in cancer therapy. This research opens the door to larger clinical studies to explore how best to integrate statins into cancer care. If successful, this approach could provide a cost-effective strategy for reducing the global burden of colorectal cancer, which remains a significant health challenge. DOI - https://doi.org/10.18632/oncotarget.28755 Correspondence to - Sanjeev Galande - sanjeev.galande@snu.edu.in Video short - https://www.youtube.com/watch?v=A95ICULaH3Y Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28755 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, colorectal cancer, statins, SATB1, Wnt/β-catenin signaling, tumor-suppressive phenotype To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Dan Casey was back with another installment of the Big Red Bench. Plenty to get through including hearing from Pat Ryan and John Kiely ahead of next Saturday's Munster final. We also hear from Cork's Megan Connolly ahead of the WNT clash vs Slovenia on Tuesday

TW - SA of a minor May 24th: Jesse Dirkhising Born (1986) Not everyone deserves your trust. On May 24th 1986 a young boy was born. A boy whose parents trusted two grown men with him. A deadly decision. https://en.wikipedia.org/wiki/Murder_of_Jesse_Dirkhising, https://www.allgaylong.com/blog/murder-jesse-dirkhising/, https://www.oddmurdersandmysteries.com/the-murder-of-jesse-dirkhising/, https://www.arkansasonline.com/news/2019/jun/08/judge-denies-new-dna-tests-for-child-ra/, https://abcnews.go.com/WNT/story?id=131125&page=1 Learn more about your ad choices. Visit megaphone.fm/adchoices

On Friday's Football Daily, Phil Egan brings you a full preview of this evening's League of Ireland action. We'll have live and exclusive coverage of St. Pats' Dublin derby with Shelbourne on tonight's Off The Ball, with coverage starting on Newstalk from 7pm. We hear from Pat's boss Stephen Kenny, Galway captain Greg Cunningham, Shamrock Rovers manager Stephen Bradley, Waterford forward Trae Coyle, Derry boss Tiernan Lynch and Sligo assistant Ryan Casey on tonight's top flight games. The FAI have strongly hit back at Kerry's claims of being 'bullied into silence'. Cobh Ramblers have moved to allay fears around their financial future. The Republic of Ireland. WNT have an afternoon appointment in Greece. And David Moyes responds to death threats aimed at Everton defender James Tarkowski.

On Friday's Football Daily, Phil Egan brings you a full preview of this evening's League of Ireland action. We'll have live and exclusive coverage of St. Pats' Dublin derby with Shelbourne on tonight's Off The Ball, with coverage starting on Newstalk from 7pm. We hear from Pat's boss Stephen Kenny, Galway captain Greg Cunningham, Shamrock Rovers manager Stephen Bradley, Waterford forward Trae Coyle, Derry boss Tiernan Lynch and Sligo assistant Ryan Casey on tonight's top flight games. The FAI have strongly hit back at Kerry's claims of being 'bullied into silence'. Cobh Ramblers have moved to allay fears around their financial future. The Republic of Ireland. WNT have an afternoon appointment in Greece. And David Moyes responds to death threats aimed at Everton defender James Tarkowski.

On Thursday's Football Daily, Phil Egan brings you all the reaction worth airing from the Merseyside derby. Liverpool skipper Virgil van Dijk speaks to OTB about their Premier League dreams, while David Moyes claims last night's winner should not have stood. PGMOL have reacted to James Tarkowski's contentious challenge on Alexis MacAllister. Amber Barrett discusses a potential 50th WNT cap. And the Women's World Cup is coming to Belfast.

On Thursday's Football Daily, Phil Egan brings you all the reaction worth airing from the Merseyside derby. Liverpool skipper Virgil van Dijk speaks to OTB about their Premier League dreams, while David Moyes claims last night's winner should not have stood. PGMOL have reacted to James Tarkowski's contentious challenge on Alexis MacAllister. Amber Barrett discusses a potential 50th WNT cap. And the Women's World Cup is coming to Belfast.

Join the lads as they talk about Finn Azaz perhaps making a move to South London, more games in June and the brand new WNT shirt is finally released and of course they take a look at how the Boys in Green got on across the water.

BUFFALO, NY - March 25, 2025 – A new #review was #published in Oncotarget, Volume 16, on March 13, 2025, titled “Signaling pathway dysregulation in breast cancer." In this review article, Dinara Ryspayeva and colleagues from Brown University provide a detailed look at how breast cancer cells change the way they communicate and grow—helping tumors survive, spread, and resist treatment. The review highlights how certain gene mutations and disrupted signaling pathways influence therapy response across different types of breast cancer. It also outlines current treatment strategies and clinical trials, offering insights that could improve care for patients with aggressive or hard-to-treat cancers. Breast cancer is the most common cancer in women and a major cause of cancer-related deaths worldwide. While many patients respond to treatment at first, some cancers return or stop responding. The review explores how signaling disruptions inside tumor cells are often behind these setbacks. The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These pathways help control cell growth, division, DNA repair, and survival. When altered by mutations or other changes, they can promote tumor progression and resistance to treatment. One of the most disrupted pathways is PI3K/Akt/mTOR. It plays a central role in cell growth, but in many breast cancers—especially hormone receptor-positive and HER2-positive types—it becomes overactive due to gene mutations, or the loss of a tumor-suppressing protein called PTEN. “Up to 25–40% of BC cases exhibit variations that hyperactivate the PI3K/Akt/mTOR pathway, underscoring its critical role in oncogenesis.” Another key pathway, RAS/RAF/MEK/ERK, can also promote tumor growth. Even without mutations, it may become active when primary pathways are blocked, particularly in HER2-positive and triple-negative breast cancers. The review also highlights several new and emerging treatments aimed at blocking down these signaling pathways. Some drugs are already approved, while others are in clinical trials. The authors suggest that combining different treatments may help stop multiple pathways at once, making it harder for cancer cells to adapt. Matching treatments to each tumor's unique genetic changes could also improve patient outcomes. This comprehensive review gives researchers and clinicians a clearer understanding of how breast cancer resists treatment and where future therapies should focus. A better understanding of these disrupted signaling systems could lead to more personalized and effective treatments for patients facing aggressive or recurring disease. DOI - https://doi.org/10.18632/oncotarget.28701 Correspondence to - Dinara Ryspayeva - dinara_ryspayeva@brown.edu Video short - https://www.youtube.com/watch?v=ppFVGwdztHI Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Stephen Kelly, Daryl Horgan and Richie Towell join Raf Diallo to react to Ireland's win over Bulgaria. The latter two reminisce about their Dundalk heyday and the reset at Oriel Park, while Shelbourne's Rachel Graham and RTÉ Sport's Anthony Pyne look ahead to the WNT squad announcement.

Welcome to Wednesday's OTB Breakfast Bite - your FREE bitesize taster of this morning's full Off The Ball Breakfast. On a packed show this morning, former Ireland defender Méabh de Búrca reviewed a disastrous evening for the WNT in Slovenia. GAA referee David Coldrick discusses the new rules in Gaelic football.Former Munster hooker Mike Sherry joins to talk Six Nations and more.And we were joined by Watford's on-loan defender James Abankwah. And that's where we take our Bite this morning, but not until after Ger and Colm address Ireland's terrible Women's Nations League result in Koper. Catch Off The Ball Breakfast LIVE weekday mornings from 7:30am or just search for Off The Ball Breakfast and get the podcast on the Off The Ball app. SUBSCRIBE at OffTheBall.com/join

Welcome to Wednesday's OTB Breakfast Bite - your FREE bitesize taster of this morning's full Off The Ball Breakfast. On a packed show this morning, former Ireland defender Méabh de Búrca reviewed a disastrous evening for the WNT in Slovenia. GAA referee David Coldrick discusses the new rules in Gaelic football.Former Munster hooker Mike Sherry joins to talk Six Nations and more.And we were joined by Watford's on-loan defender James Abankwah. And that's where we take our Bite this morning, but not until after Ger and Colm address Ireland's terrible Women's Nations League result in Koper. Catch Off The Ball Breakfast LIVE weekday mornings from 7:30am or just search for Off The Ball Breakfast and get the podcast on the Off The Ball app. SUBSCRIBE at OffTheBall.com/join

On Friday's Football Daily, Phil Egan helps preview tonight's Women's Nations League clash of the Republic of Ireland and Türkiye at Tallaght Stadium. Ahead of that game, Katie McCabe has blasted the FAI's treatment of Colin Healy as 'not good enough', we speak to the skipper. And new WNT manager Carla Ward's view of the domestic game seems to be at odds with MNT counterpart Heimir Hallgrimsson. Nathan catches up with Stephen Bradley following Shamrock Rovers Conference League exit. And we hear from Stephen Kenny, Greg Cunningham and Tiernan Lynch ahead of tonight's Premier Division fixtures. Don't forget, Galway United's clash with St. Pat's is LIVE & EXCLUSIVE on tonight's Off The Ball.

On Friday's Football Daily, Phil Egan helps preview tonight's Women's Nations League clash of the Republic of Ireland and Türkiye at Tallaght Stadium. Ahead of that game, Katie McCabe has blasted the FAI's treatment of Colin Healy as 'not good enough', we speak to the skipper. And new WNT manager Carla Ward's view of the domestic game seems to be at odds with MNT counterpart Heimir Hallgrimsson. Nathan catches up with Stephen Bradley following Shamrock Rovers Conference League exit. And we hear from Stephen Kenny, Greg Cunningham and Tiernan Lynch ahead of tonight's Premier Division fixtures. Don't forget, Galway United's clash with St. Pat's is LIVE & EXCLUSIVE on tonight's Off The Ball.

BUFFALO, NY – February 14, 2025 – A new #review was #published in Oncotarget, Volume 16, on February 12, 2025, titled “SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types.” Authors Elodie Verdier, Nathalie Gaspar, Maria Eugenia Marques Da Costa, and Antonin Marchais from the Gustave Roussy Cancer Campus analyzed recent studies on a gene called SETDB1, which may play a key role in osteosarcoma, a type of bone cancer that mostly affects teenagers and young adults. Their review highlights how SETDB1 helps cancer cells grow, resist treatment, and avoid the immune system. Because of this, blocking SETDB1 could be a promising new way to treat osteosarcoma. Osteosarcoma is a fast-growing bone cancer that is usually treated with surgery and chemotherapy. However, if the cancer spreads or returns, treatment options are very limited. Scientists are searching for new ways to stop this disease, and recent studies have found that osteosarcoma cells often have extra copies of the SETDB1 gene. This seems to make the cancer more aggressive and harder to treat. “Whole exome sequencing of osteosarcoma samples from both diagnosis and relapses has highlighted several factors, including SETDB1, that are amplified in the most aggressive forms of the disease.” SETDB1 is involved in epigenetics, meaning it affects how genes are turned on and off without changing the DNA itself. The review explains that SETDB1 helps tumors hide from the immune system, making it difficult for the body to fight the cancer naturally. The researchers believe that blocking SETDB1 could help the immune system recognize and attack osteosarcoma cells. Some experimental drugs that target SETDB1 are already being tested in the lab. The review also describes how SETDB1 influences key cancer pathways, such as Wnt signaling, which helps cancer cells grow, and epithelial-mesenchymal transition (EMT), a process that allows cancer to spread. The authors suggest that combining SETDB1-blocking drugs with immunotherapy or radiation could be an effective new strategy for treating osteosarcoma. Another key finding is that SETDB1 may help cancer cells become resistant to chemotherapy, making treatment less effective. This means that drugs targeting SETDB1 could not only slow cancer growth but also make existing treatments work better. While more research is needed, this review brings attention to SETDB1 as a potential treatment target. Scientists hope that a deeper understanding of SETDB1 will lead to new therapies that improve survival rates for osteosarcoma patients. DOI - https://doi.org/10.18632/oncotarget.28688 Correspondence to - Antonin Marchais - antonin.marchais@gustaveroussy.fr, and Maria Eugenia Marques Da Costa - jenny.marquescosta@gustaveroussy.fr Video short - https://www.youtube.com/watch?v=f9WgaDoEubs About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

On Wednesday's Football Daily, Phil Egan brings you details of Mason Melia's blockbuster move to Tottenham, and what it means for St. Pat's. Denise O'Sullivan has strongly criticised the FAI's treatment of former WNT assistant Colin Healy. Bohemians are weighing up a move for former Premier League striker Lys Mousset, and we hear from another of their arrivals - Connor Parsons. Arne Slot discusses Conor Bradley replacing Trent Alexander-Arnold for Liverpool in the Carabao Cup. And Adam Idah is ready to take on more responsibility at Celtic.

On Wednesday's Football Daily, Phil Egan brings you details of Mason Melia's blockbuster move to Tottenham, and what it means for St. Pat's. Denise O'Sullivan has strongly criticised the FAI's treatment of former WNT assistant Colin Healy. Bohemians are weighing up a move for former Premier League striker Lys Mousset, and we hear from another of their arrivals - Connor Parsons. Arne Slot discusses Conor Bradley replacing Trent Alexander-Arnold for Liverpool in the Carabao Cup. And Adam Idah is ready to take on more responsibility at Celtic.

In case you missed it, here is episode one from our Settle In Series, as a bonus listen for all of our GAA Fans!Former Ireland international and coach Linda Gorman joined Eoin Sheahan to discuss how she's tackling ageism in sport by encouraging more people to take up walking football and she also discussed how much support for the women's game in Ireland has changed since she played on the first ever WNT over 50 years ago.‘Settle in' in partnership with Guinness 0.0.

In case you missed it, here is episode one from our Settle In Series, as a bonus listen for all of our GAA Fans! Former Ireland international and coach Linda Gorman joined Eoin Sheahan to discuss how she's tackling ageism in sport by encouraging more people to take up walking football and she also discussed how much support for the women's game in Ireland has changed since she played on the first ever WNT over 50 years ago.‘Settle in' in partnership with Guinness 0.0.

Former Ireland international and coach Linda Gorman joined Eoin Sheahan to discuss how she's tackling ageism in sport by encouraging more people to take up walking football and she also discussed how much support for the women's game in Ireland has changed since she played on the first ever WNT over 50 years ago.‘Settle in' in partnership with Guinness 0.0.

rWotD Episode 2794: Cerberus (protein) Welcome to Random Wiki of the Day, your journey through Wikipedia’s vast and varied content, one random article at a time.The random article for Friday, 27 December 2024 is Cerberus (protein).Cerberus is a protein that in humans is encoded by the CER1 gene. Cerberus is a signaling molecule which contributes to the formation of the head, heart and left-right asymmetry of internal organs. This gene varies slightly from species to species but its overall functions seem to be similar.Cerberus is secreted by the anterior visceral endoderm and blocks the action of BMP, Nodal and Wnt, secreted by the primitive node, which allows for the formation of a head region. This is accomplished by inhibiting the formation of mesoderm in this region. Xenopus Cerberus causes a protein to be secreted that is able to induce the formation of an ectopic head. Knockdown experiments have helped to explain Cerberus's role in both the formation of the head and left and right symmetry. These experiments have shown that Cerberus helps to keep Nodal from crossing to the right side of the developing embryo, allowing left and right asymmetry to form. This is why misexpression of Cerberus can cause the heart to fold in the opposite direction during development. When Cerberus is “knocked down” and BMP and Wnt are up regulated the head does not form. Other experiments using mice that this gene has been “knocked out” showed no head defects, which suggest that it is the combination of the up regulation of BMP and Wnt along with the absence of Cerberus that causes this defect. For the heart, Cerberus is one of several factors that inhibits Nodal to initiate cardiomyogenic differentiation The Cerberus gene family produces many different signal proteins that are antagonistically involved in establishing anterior-posterior patterning and left-right patterning in vertebrate embryos.This recording reflects the Wikipedia text as of 01:18 UTC on Friday, 27 December 2024.For the full current version of the article, see Cerberus (protein) on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Mastodon at @wikioftheday@masto.ai.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm generative Ruth.

The prospect of a minimally toxic, chemotherapy-free cure for hepatoblastoma is held out by findings from a mouse model using the small-molecule drug WNTinib that inhibits the Wnt signaling pathway involved with cancer growth. Lead author Ugnė Balaševičiūtė, a pre-doctoral researcher in Translational Research of the Hepatic Oncology Group led by Josep M. Llovet, Professor at the Institut D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS) in Barcelona, Spain, reported that the CTNNB1 (catenin beta-1 protein) gene targeted by WNTinib was expressed in 90 percent of all hepatoblastomas. Hopes were high that a safer alternative to chemotherapy in humans was on the way.

On Friday's Football Daily, Phil Egan brings you reaction to Shamrock Rovers' invaluable point in the Conference League, as we hear from Stephen Bradley. Ruben Amorim admits his Manchester United players are giving him anxiety. Eileen Gleeson and Denise O'Sullivan speak ahead of tonight's vital Euro playoff for Ireland's WNT in Cardiff. And we hear from new Coventry manager Frank Lampard.

On Friday's Football Daily, Phil Egan brings you reaction to Shamrock Rovers' invaluable point in the Conference League, as we hear from Stephen Bradley. Ruben Amorim admits his Manchester United players are giving him anxiety. Eileen Gleeson and Denise O'Sullivan speak ahead of tonight's vital Euro playoff for Ireland's WNT in Cardiff. And we hear from new Coventry manager Frank Lampard.

Former Ireland international and coach Linda Gorman joined Eoin Sheahan to discuss how she's tackling ageism in sport by encouraging more people to take up walking football and she also discussed how much support for the women's game in Ireland has changed since she played on the first ever WNT over 50 years ago.‘Settle in' in partnership with Guinness 0.0.

On this episode of the Modern Facilities Management Podcast, Griffin Hamilton interviews Yaron Dycian from Wint.AI, discussing the critical issues of water management in buildings. They explore the significant waste of water, the financial implications of leaks, and how Wint leverages AI for anomaly detection and predictive analytics to optimize water usage. The conversation also touches on proactive measures facilities managers can take and the future of water management technology in buildings.Chapters00:00Introduction to Wnt and Water Management03:01The Impact of Water Waste05:55Leveraging AI for Water Management09:00Insights and Analytics in Water Usage12:04Proactive Measures for Water Management14:59Future of Water Management in Facilities17:57Career Influences and Closing ThoughtsInterested in closing the skills gap? Check out our friends at Interplay Learning!

Vitamin D is not a vitamin; it's a hormone intimately involved in 10% of our genes. If you don't have enough vitamin D, it can interfere with the genes responsible for hair growth. There is also a very high concentration of vitamin D receptors in the hair follicle. Without enough vitamin D, your immune system is at risk of autoimmune conditions, including alopecia. Vitamin D supports the T cells that help combat autoimmune diseases. Psoriasis, dandruff, and dermatitis are also related to low vitamin D. Magnesium is the most potent regulator of calcium and is involved with enzymes important for hair health. It's also essential for the proper function of vitamin D. There are 2 systems of vitamin D: one that controls calcium and one that has several functions, including hair growth and hair restoration. This form of vitamin D has a 24-hour half-life, so you need daily sun or supplements to prevent a hair loss problem. There is a worldwide vitamin D deficiency epidemic! Several factors contribute to this massive vitamin D deficiency problem, including genetics, skin color, insulin resistance, diabetes, obesity, and air pollution. Your blood vitamin D levels should be at least 70 to 100 ng/mL. You need at least 20,000 IU of vitamin D daily and 50 mg of magnesium to support hair growth. Zinc, iron, vitamin B12, and omega-3 fatty acids are also essential for hair restoration. Key genes involved in hair growth: 1. Sonic Hedgehog (SHH) gene 2. WNT genes 3. BMP (Bone Morphogenetic Protein) genes 4. FGF (Fibroblast Growth Factor) genes 5. TGF-β (Transforming Growth Factor-Beta) genes 6. LEF1 (Lymphoid Enhancer-Binding Factor 1) 7. PDGF (Platelet-Derived Growth Factor) 8. Dkk (Dickkopf WNT Signaling Pathway Inhibitor) genes 9. CTNNB1 (Beta-Catenin)

Bart drops by to talk all the NT talk- USYNT and the U20 loss in Mexico, the USMNT losing in the knockouts in Paris and the WNT continuing to chase a medal under Emma Hayes

Ryan and Graham are here to deliver an update on the US teams at Paris 2024! It's the end of the road for the men, whose limitations were exposed by Morocco, while the WNT survived a technical battle with Japan to progress! JOIN THE TSS+ PATREON! Check out our Patreon, which houses bonus podcasts, access to our exclusive Discord, blog posts, videos, and much more. Become a member today at patreon.com/totalsoccershow! Learn more about your ad choices. Visit megaphone.fm/adchoices

Ryan and Graham are here to deliver an update on the US teams at Paris 2024! It's the end of the road for the men, whose limitations were exposed by Morocco, while the WNT survived a technical battle with Japan to progress!JOIN THE TSS+ PATREON!Check out our Patreon, which houses bonus podcasts, access to our exclusive Discord, blog posts, videos, and much more.Become a member today at patreon.com/totalsoccershow! Hosted on Acast. See acast.com/privacy for more information.

Belz, Vince and Tara recap the 2-1 win over Australia. Not as cathartic as the win over Germany, but still lots to celebrate, plenty to nitpick. The WNT and Emma Hayes have given us a nine-point window! So we had to dust off an old number for the intro to this episode. Subscribe to Scuffed on Patreon! Patrons get a private ad-free feed for all episodes that go out on the public feed, plus the Monday Review every week with Watke and Vince. Patrons also get access to our private Discord server, live call-in shows, and the full catalog of historic recaps we've made: https://www.patreon.com/scuffed

Dr. Shukry Habib is an Associate Professor in the Department of Biomedical Sciences at the Université de Lausanne. His lab works at the intersection of stem cell biology, biophysics, and tissue engineering to investigate how tissues form. He talks about developing a transplantable bandage for bone repair and the role of Wnt signaling and cytonemes in development.

We discuss remarkable preliminary results from the the use of intravitreal EYE-103, a novel Wnt pathway agonist in the treatment of DME and neovascular AMD with Dr. Charles Wykoff of Houston Texas.

In this episode of Behind the Business, founder Niamh Tallon and co-founder Mohammed Mahommed sat down to chat about what the Her Sport team has been up to over the past few months! From the team expanding to reflecting on women's sport in 2023, join Niamh and Mohammed as they share the exciting developments, upcoming projects and new goals for the business. 0:19 Update on the #hersport team 3:18 What is the Going For Growth Programme? 7:26 Her Sport's rapid social growth 9:16 Like & Subscribe 12:20 Womens sport in 2023 14:50 FIFA 2023 Women's World Cup 18:00 Ireland's WNT playing at the Aviva 24:40 New campaigns 27:19 #DOITFORHER 30:22 What is the aim of Her Sport? 33:28 Being a Her Sport MVP 40:00 The value of education 47:29 Expanding the Her Sport Workshops 51:13 What is the Her Sport Awards? 56:59 How you can help us Visit the website https://hersport.ie/ Check out the Her Sport channels Instagram - https://www.instagram.com/hersport.ie Facebook - https://www.facebook.com/HerSport.ie/ Twitter - https://twitter.com/HerSportDotIE About Her Sport: Her Sport is a media platform centred on bringing the latest Irish and international women's sports news. Her Sport aims to empower women in sport, inspire more female participation, increase opportunity and level the playing field for future generations. Our objective is to create real and tangible change. Contact us: hello@hersport.ie

Peter and Alex gather at the west-coast NFP Studios to recap an incredible night at Christine Sinclair Place on Tuesday night, including the future of the CanWNT and whether the CSA should prioritize BC Place as a venue for future matches. They also discuss York United's new ownership, burning listener questions about the MNT's future and Wilfried Nancy's stock after reaching the MLS Cup Final with the Columbus Crew. FOLLOW US ON SOCIAL: Northern Fútbol: @NorthernFutbol Peter Galindo: @GalindoPW Alex Gangué-Ruzic: @AlexGangueRuzic Ben Steiner: @BenSteiner00 RUNNING ORDER: 2:41 – That Christine Sinclair Place atmosphere

Reunited for the holiday Friendsgiving episode is Greggo and TK and at long last the ladies of Shea Butter FC, coming back a trip down the road to San Diego for the NWSL Championship which saw Gotham claim their first NWSL chip over a fallen Megan Rapinoe and OL Reign. We recap their Championship Week experience and coming to glances with famous beefs, and the re-emergence of Midge Purce on the big stage.We also come off the big announcement by US Soccer naming Chelsea Head Coach Emma Hayes their new WNT Coach, and what this means for the WNT going forward and also how such a big hire affects the men's side as well. FTC also hits up the opening rounds of the MLS playoffs, and in 2UP/2down we get on the end of the Hollywood strikes, the Falcons and Raiders, the NBA In-Season Tournament, and more!Follow us on social media!Twitter, Instagram, and Facebook and now Threads @FTCUTD!!TikTok @ftcutdpod!Get 10% Off with the code CULTURE10 at ftcutd.com/shop, good thru Thanksgiving weekend! Hosted on Acast. See acast.com/privacy for more information.

Greg, Vince, Tara and Belz talk through the surprise of the weekend, first reported by Joe Lowery at Backheeled, that Chelsea manager and arguably the best coach in women's soccer Emma Hayes has agreed to terms with the USSF to coach the women's national team. We talk about her background, her ideas about American soccer development, the ways she is likely to manage the WNT and the as yet unclear transition for her from Chelsea to USA.https://twitter.com/Backheeled Subscribe to Scuffed on Patreon! Patrons get a private feed for the Monday Review, which is, among other things, a run-down of club action for national team players every week with Watke and Vince. We have recently added patron-only content that's available every Friday. Patrons also get access to our private Discord server, live call-in shows, and the full catalog of historic recaps we've made: https://www.patreon.com/scuffed

The USA Soccercast is back with Episode 117, as we get ready for the USWNT's matches against Colombia this weekend as well as dip into the mailbag. The USWNT take on Colombia twice this weekend, with the first one coming tonight in Salt Lake City. We quickly preview the matchup, the USWNT roster, and a few players from Las Cafeteras that fans should pay attention to when they hit the field. These matches are important as we start to see who tries to separate themselves and show they should be on the shortened roster for the Olympics next summer. After the break, we dip into the mailbag for a great question: who is your all-time USWNT gameday roster? That includes the starting XI and your bench. We go through each position in the starting XI and also who would make the bench. Of course, we want to know who your all-time WNT roster would be, so chime in on Twitter or via email! Also, don't forget to follow us on Twitter and to tap into our Linktree, which will give you access to all our affiliate links: Fanatics, Homage, BreakingT, and the MLS Store. Fall is coming, which means a great chance to get some new stuff. Now, you'll be able to save some money on all the cool soccer apparel or anything else you're interested in wearing! And finally, tag us on Twitter or email USA Soccercast at Gmail dot com with any topic suggestions or questions for the show. We'd like to have a mailbag episode, and we could use your questions! Learn more about your ad choices. Visit megaphone.fm/adchoices

SoccerForUSPod's Bart Keeler drops by to talk about the international window from the US perspective (MNT, YNT, WNT) and we get our weekly run of reffingdownhere looking at the job and the decisions of the week... Here's the segment in its entirety from SDH

SoccerForUSPod's Bart Keeler drops by to talk about the international window from the US perspective (MNT, YNT, WNT) and we get our weekly run of reffingdownhere looking at the job and the decisions of the week...Here's the segment in its entirety from SDH

It's a busy SDH Wall Pass Wednesday brings in coaching carousel and the new job for Wayne Rooney Hour 2 brings Dylan Butler in to talk MLS and SoccerForUSPod's Bart Keeler drops by to talk about the international window from the US perspective (MNT, YNT, WNT) and we get our weekly run of reffingdownhere looking at the job and the decisions of the week...

It's a busy SDHWall Pass Wednesday brings in coaching carousel and the new job for Wayne RooneyHour 2 brings Dylan Butler in to talk MLS and SoccerForUSPod's Bart Keeler drops by to talk about the international window from the US perspective (MNT, YNT, WNT) and we get our weekly run of reffingdownhere looking at the job and the decisions of the week...

It's just Kathleen & Karen this week as Emma attends to some very important WNT business... but we've still got all the usual WSL analysis you could hope for, as well as the Team of the Week!The COYGIG Pod on Off The Ball is in association with Cadbury, the official snack partner to the Republic of Ireland's Women's National Team.#CadburySupporterAndAHalf | Cadbury Ireland

Stephen Doyle and Kathleen McNamee react to the Republic of Ireland's WNT's first-ever game at the Aviva which resulted in a 3-0 win over Northern Ireland. Football on Off the Ball with William Hill Ireland.

Jenny Chiu, Lisa Carlin, Jordan Angeli and Darian Jenkins react to Midge Purce and M.A. Vignola's late additions to the USWNT roster (01:41) and the RFEF giving Spain's WNT players an ultimatum about returning to international duty (04:56). Then, a recap of another weekend of twists and turns in NWSL beginning with the Esther González Show in NY/NJ Gotham's win over Washington Spirit (08:59). We hear from Chicago Red Stars and Canada defender Bianca St-Georges about overcoming physical and mental setbacks (22:23). With three matchdays to go in NWSL regular season, the crew make their playoff predictions (31:33). And a look at the must-see matchups in the upcoming international break (40:55). Watch USWNT, NWSL and WSL games on P+" with a link to https://www.paramountplus.com/home/ Attacking Third is available for free on the Audacy app as well as Apple Podcasts, Spotify, Google Podcasts, Stitcher and wherever else you listen to podcasts.  Follow the Attacking Third team on Twitter: @AttackingThird, @SandHerrera_, @LisaCarlin32, @Jordangeli , @JennyaChiu and @Darian_Jenks. Visit the Attacking Third YouTube channel: https://www.youtube.com/attackingthird You can listen to Attacking Third on your smart speakers! Simply say "Alexa, play the latest episode of the Attacking Third podcast" or "Hey Google, play the latest episode of the Attacking Third podcast." For more soccer coverage from CBS Sports, visit https://www.cbssports.com/soccer/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Jenny Chiu, Lisa Carlin, Christine Cupo and Darian Jenkins discuss the latest out of Spain as the federation has fired WNT head coach Jorge Vilda and Jenni Hermoso has spoken out. They preview the Challenge Cup semifinals giving tactical breakdowns. Sandra Herrera joins to share her players to watch. Watch Attacking Third for FREE, live Golazo Network every Monday, Wednesday and Friday at 4pmET on Paramount+ or the CBS Sports App. Watch USWNT, NWSL and WSL games on P+" with a link to https://www.paramountplus.com/home/ Attacking Third is available for free on the Audacy app as well as Apple Podcasts, Spotify, Google Podcasts, Stitcher and wherever else you listen to podcasts.  Follow the Attacking Third team on Twitter: @AttackingThird, @SandHerrera_, @LisaCarlin32, @Jordangeli , @JennyaChiu and @Darian_Jenks. Visit the Attacking Third YouTube channel: https://www.youtube.com/attackingthird You can listen to Attacking Third on your smart speakers! Simply say "Alexa, play the latest episode of the Attacking Third podcast" or "Hey Google, play the latest episode of the Attacking Third podcast." For more soccer coverage from CBS Sports, visit https://www.cbssports.com/soccer/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

In this episode of the Epigenetics Podcast, we talked to Claudio Cantù from Linköping University about his work on peak blacklists, peak concordance and what is a peak in CUT&RUN. Our host Stefan Dillinger and guest Claudio Cantù dive into the topic of when we can be sure that a peak is a peak. To help with this, Claudio Cantù's group has been working on defining a set of suspicious peaks that can be used as a "peak blacklist" and can be subtracted to clean up CUT&RUN data sets. The lab also worked on a method called ICEBERG (Increased Capture of Enrichment By Exhaustive Replicate aGgregation) to help define peaks from a number of experimental replicates. By using this algorithm, the team is trying to discover the beta-catenin binding profile, not the tip of the beta-catenin binding iceberg, but the whole of the beta-catenin binding profile.   References Zambanini, G., Nordin, A., Jonasson, M., Pagella, P., & Cantù, C. (2022). A new CUT&RUN low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/β-catenin tissue-specific genomic targets. Development (Cambridge, England), 149(23), dev201124. https://doi.org/10.1242/dev.201124 Nordin, A., Zambanini, G., Pagella, P., & Cantù, C. (2022). The CUT&RUN Blacklist of Problematic Regions of the Genome [Preprint]. Genomics. https://doi.org/10.1101/2022.11.11.516118 Nordin, A., Pagella, P., Zambanini, G., & Cantu, C. (2023). Exhaustive identification of genome-wide binding events of transcriptional regulators with ICEBERG [Preprint]. Genomics. https://doi.org/10.1101/2023.06.29.547050   Related Episodes Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff) Single Cell Epigenomics in Neuronal Development (Tim Petros)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

Biden is a proven traitor. Kevin McCarthy must impeach him or the Freedom Caucus must remove McCarthy. A Deep DiveIt's pass or fail for McCarthy AND the Freedom Caucus (we already know where McConnell stands -- with Biden's Crime Family). Either Kevin McCarthy and the House GOP vote to Impeach Biden or the Freedom Caucus votes to vacate the Speaker's Chair. Why?Massive election rigging. Obstruction of Justice.Taking bribes.Garland must be removed. Why?All the same reasons, plus lying to Congress. What does God's Word say? Psalm 52:1-7Why do you boast of evil, you mighty hero? Why do you boast all day long, you who are a disgrace in the eyes of God?2 You who practice deceit, your tongue plots destruction; it is like a sharpened razor.3 You love evil rather than good, falsehood rather than speaking the truth.[c]4 You love every harmful word, you deceitful tongue!5 Surely God will bring you down to everlasting ruin: He will snatch you up and pluck you from your tent; he will uproot you from the land of the living.6 The righteous will see and fear; they will laugh at you, saying,7 “Here now is the man who did not make God his strongholdbut trusted in his great wealth and grew strong by destroying others!”1 Corinthians 5:11 - (WNT means the Weymouth New Testament, known also as The New Testament in Modern Speech or The Modern Speech New Testament. It is a translation into "modern" English used in the nineteenth century from the base-text of The Resultant Greek Testament by Richard Francis Weymouth.)“But what I meant was that you were not to associate with any one bearing the name of "brother," if he was addicted to fornication or avarice or idol-worship or abusive language or hard-drinking or greed of gain. With such a man you ought not even to eat.”Episode 918 Links:Whistleblower Transcripts Show Deep-State Election Rigging For Biden Was Way Bigger Than A LaptopAG Garland promised the American people in public testimony the prosecutor handling Hunter Biden's case, U.S. Attorney for Delaware David Weiss, could bring charges against Hunter Biden outside of Delaware.WaysandMeansGOP just voted to release 14 hours of transcribed interviews with 2 IRS whistleblowers. Their story of how the federal government handled an investigation into a “high-profile individual” is stunning. READ:Remember where this all started who who ran the op: Explosive New FBI Notes Confirm Obama Directed Anti-Flynn Operation, By: Sean Davis And Mollie Hemingway, June 24, 2020White House National Security Council Coordinator WALKS OUT after being asked about Hunter Biden's WhatsApp messages with China implicating President BidenIRS investigators wanted to search a Virginia storage unit controlled by Hunter Biden, where he stored files & documents. DOJ prosecutors went and tipped off Hunter's lawyers.Statement from IRS Agent Gary Shapley's legal team: "In an October 7, 2022, meeting at the Delaware U.S. Attorney's Office, U.S. Attorney David Weiss told six witnesses he did not have authority to charge in other districts and had thus requested special counsel status. Those six witnesses include Baltimore FBI Special Agent in Charge Tom Sobocinski and Assistant Special Agent in Charge Ryeshia Holley, IRS Assistant Special Agent in Charge Gary Shapley and Special Agent in Charge Darrell Waldon, who also independently and contemporaneously corroborated Mr. Shapley's account in an email, now public as Exhibit 10, following p. 148 of his testimony transcript. Mr. Shapley would have no insight into why Mr. Weiss would make these statements at the October 7, 2022 meeting if they were false. That Mr. Weiss made these statements is easily corroborated, and it is up to him and the Justice Department to reconcile the evidence of his October 7, 2022 statements with contrary statements by Mr. Weiss and the Attorney General to Congress."Hunter's Attorney: “Hunter Biden attorney responds to IRS agent testimony - and refers to 2017 message suggesting Joe Biden proximity to China deal: "Any verifiable words or actions of my client, in the midst of a horrible addiction, are solely his own and have no connection to anyone in his family"Here is 3 minutes and 35 seconds of Karine Jean-Pierre refusing to answer any questions about Hunter Biden. "As it relates to anything related to Hunter Biden, I am just not going to respond to it from here."Garland: "Some have chosen to attack the integrity of the Justice Department by claiming that we do not treat cases alike. This constitutes an attack on an institution that is essential to American democracy... Nothing could be further from the truth."“Perspective on the Hunter Biden deal: I've reviewed data on 189,000 firearm possession cases by the DOJ. Not a single diversion. In fact, among all cases prosecuted by the DOJ less than 1% were resolved by a diversion.” - Brett L. Tolman, Executive Director of Right On Crime, Former US Attorney4Patriots https://4patriots.com Protect your family with Food kits, solar generators and more at 4Patriots. Use code TODD for 10% off your first purchase. Alan's Soaps https://alanssoaps.com/TODD Use coupon code ‘TODD' to save an additional 10% off the bundle price. BiOptimizers https://magbreakthrough.com/todd Use promo code TODD for 10% off your order. Bonefrog https://bonefrog.us Enter promo code TODD at checkout to receive 10% off your subscription. Bulwark Capital http://KnowYourRiskRadio.com Find out how Bulwark Capital Actively Manages risk. Call 866-779-RISK or visit KnowYourRiskRadio.com Patriot Mobile https://patriotmobile.com/herman Get free activation today with offer code HERMAN. Visit or call 878-PATRIOT. RuffGreens https://ruffgreens.com/todd Get your FREE Jumpstart Trial Bag of Ruff Greens, simply cover shipping. Visit or call 877-MYDOG-64. SOTA Weight Loss https://sotaweightloss.com SOTA Weight Loss is, say it with me now, STATE OF THE ART! Sound of Freedom https://angel.com/freedom Join the two million and see Sound of Freedom in theaters July 4th. GreenHaven Interactive https://greenhaveninteractive.com Digital Marketing including search engine optimization and website design.

Videos : The Covid Redemption with Tim Robbins – #048 – Stay Free with Russell Brand MP calls for complete suspension of mRNA jab in extraordinary British Parliamentary speech Turmeric studied for its ability to seek out and destroy cancer stem cells, the source of all tumors Montclair State University, December 13, 202 Turmeric has gained immense popularity over the years not just for the unique flavor it adds to dishes like curries, but also for its various health benefits. One of its most promising therapeutic applications is as a natural remedy for cancer. Although the anticancer potential of turmeric isn't new, a recent study published in Cancer Letters further proved the importance of this golden spice in understanding and treating cancer. The team of American researchers evaluated the ability of curcumin, which is a polyphenol in turmeric, to target cancer stem cells that are assumed to be the primary cause of cancer tumor formation and malignancy. Unlike conventional cancer models used in previous studies, the cancer stem cell model suggests that only a small population of cancer cells drive the initiation, maintenance, and growth of tumors. These stem cells regularly undergo renewal and differentiation into other cancer cells, which no longer have the ability to regenerate themselves. Therefore, in this model, cancer stem cells that are not killed by treatments lead to the formation of more invasive and treatment-resistant tumors. In this study, the researchers found that curcumin is more effective in eradicating cancer since unlike conventional treatments, this polyphenol also targets cancer stem cells. It can do so through various mechanisms of action, which include the following. Regulation of cancer stem cell self-renewal pathway — There are different pathways involved in the self-renewal of cancer stem cells. These include the Wnt/beta-catenin, sonic hedgehog 89 (SHH), and Notch pathways. The researchers found that curcumin can directly or indirectly interfere with these pathways in 12 different cancer cell lines Modulation of microRNA — The body contains microRNAs, which are short RNA sequences that don't encode for anything. These microRNAs regulate more than 33 percent of protein-coding genes by targeting and binding to their corresponding messenger RNAs so that these won't be expressed. In this study, the authors observed that curcumin altered microRNA expression in cancer stem cells so that they can't produce everything that they need for tumor formation and growth. Direct anti-cancer activity — Curcumin selectively targets cancer cells and programs their death. When used in conjunction with conventional anticancer agents, this effect becomes more evident and the damage typically caused by chemotherapy is no longer observed. Overall, the results of this study show that for cancer treatments to be effective, they have to target and kill cancer stem cells just like turmeric does. Otherwise, these cancer stem cells will pave the way for the formation of more invasive and treatment-resistant tumors. (NEXT) Chiropractic spinal manipulation associated with reduction in low back surgery University Hospitals Cleveland Medical Center, December 19, 2022 A recent study from University Hospitals (UH) Connor Whole Health has found that adults who initially visit a chiropractor to receive spinal manipulation for low back pain caused by disc herniation or radiculopathy (i.e., sciatica) are less likely to undergo discectomy (i.e., disc surgery) over the subsequent two years. This study was recently published in the journal BMJ Open. In this retrospective cohort study, the authors selected adult patients, age 18 to 49, from a 101 million patient United States health records network (TriNetX, Cambridge, MA, U.S.). Patients with serious pathology or urgent indications for surgery were excluded from the study. Ultimately, the authors identified 5,785 patients who initially received chiropractic spinal manipulative therapy, and the same number of patients who received other forms of medical care for their low back pain. The authors used a statistical technique called propensity score matching to control for variables that could influence the likelihood that patients would undergo discectomy. In this process, they matched patients in both cohorts according to several such as age, sex, obesity, smoking, previous injections, and medications. The authors found that patients who initially received chiropractic spinal manipulation for their low back pain were significantly less likely to undergo lumbar discectomy through two years' follow-up. At one year follow-up, 1.5% of the patients in the chiropractic cohort had undergone discectomy, compared to 2.2% of patients in the cohort receiving other care At two years' follow-up, 1.9% of the patients in the chiropractic cohort had undergone discectomy, compared to 2.4% of patients in the cohort receiving other care This study represents the first study to examine whether chiropractic care is associated with a reduction in likelihood of discectomy. (NEXT) High-intensity exercise delays Parkinson's progression Northwestern Medicine and University of Denver, December 11, 2022 High-intensity exercise three times a week is safe for individuals with early-stage Parkinson's disease and decreases worsening of motor symptoms, according to a new phase 2, multi-site trial led by Northwestern Medicine and University of Denver scientists. This is the first time scientists have tested the effects of high-intensity exercise on patients with Parkinson's disease, the second most common neurodegenerative disorder and the most common movement disorder, affecting more than a million people in the United States. It previously had been thought high-intensity exercise was too physically stressful for individuals with Parkinson's disease. “If you have Parkinson's disease and you want to delay the progression of your symptoms, you should exercise three times a week with your heart rate between 80 to 85 percent maximum. Because medications for Parkinson's have adverse side effects and reduced effectiveness over time, new treatments are needed. The randomized clinical trial included 128 participants ages 40 to 80 years old from Northwestern University, Rush University Medical Center, the University of Colorado and the University of Pittsburgh. Participants enrolled in the Study in Parkinson Disease of Exercise (SPARX) were at an early stage of the disease and not taking Parkinson's medication, ensuring the results of the study were related to the exercise and not affected by medication. “The earlier in the disease you intervene, the more likely it is you can prevent the progression of the disease,” Corcos said. “We delayed worsening of symptoms for six months; whether we can prevent progression any longer than six months will require further study.” Scientists examined the safety and effects of exercise three times weekly for six months at high intensity, 80 to 85 percent of maximum heart rate, and moderate intensity, 60 to 65 percent of maximum heart rate. They compared the results to a control group who did not exercise. After six months, participants were rated by clinicians on a Parkinson's disease scale ranging from 0 to 108. The higher the number, the more severe the symptoms. Participants in the study had a score of about 20 before exercise. Those in the high intensity group stayed at 20. The group with moderate exercise got worse by 1.5 points. The group that did not exercise worsened by three points. Three points out of a score of 20 points is a 15 percent change in the primary signs of the disease and considered clinically important to patients. It makes a difference in their quality of life. (NEXT) Meditation adapts the brain to respond better to feedback University of Surrey UK, December 11, 2022 In a study in the Journal of Cognitive, Affective & Behavioral Neuroscience researchers from the University of Surrey have discovered a link between meditation and how individuals respond to feedback. Participants in the study, a mixture of experienced, novice and non-meditators, were trained to select images associated with a reward. Each pair of images had varying probabilities of a reward e.g. images that result in a reward 80 per cent of the time versus those that result in a reward 20 per cent of the time. Participants eventually learnt to select the pairing with the higher outcome. Researchers found that participants who meditated were more successful in selecting high-probability pairings indicating a tendency to learn from positive outcomes, compared to non – meditators who learned the pattern via low-probability pairings suggesting a tendency to learn from negative outcomes. During the study participants were connected to an EEG, a non-invasive method that records electrical patterns in the brain. Results from the EEG found that while all three groups responded similarly to positive feedback, the neurological response to negative feedback was highest in the non-meditation group, followed by the novice group and then by the experienced meditation group. These results indicate that the brains of meditators are less affected by negative feedback, and that this may be a result of altered dopamine levels caused by meditation. Paul Knytl, lead author and PhD candidate in psychology at the University of Surrey, said: “Humans have been meditating for over 2000 years, but the neural mechanisms of this practice are still relatively unknown. These findings demonstrate that, on a deep level, meditators respond to feedback in a more even-handed way than non-meditators, which may help to explain some of the psychological benefits they experience from the practice.” (NEXT) Caution to pregnant women on red meat diabetes link University of Adelaide (Australia) December 12, 2022 Pregnant women and women planning to become pregnant can make use of the holiday season to adjust their diets and reduce the risk of gestational diabetes, according to researchers at the University of Adelaide's Robinson Institute. The recommendation comes at a time when there is increasing evidence to suggest that red meat is linked with a higher rate of gestational diabetes in pregnant women, which poses risks to the health of both the mother and the baby. In a commentary published in the jjournal Evidence-Based Nursing, author Philippa Middleton says the latest international research shows that women who eat a lot of red and processed meats even before they become pregnant have a significant risk of developing gestational diabetes. “There have been several reports linking red meat with increased risk of type 2 diabetes, and now the work of a number of research teams worldwide is showing this link for diabetes during pregnancy,” says Ms Middleton, who is one of the Robinson Institute's research leaders. “While this news is alarming, there are also some positives. The latest research from the United States has shown that eating fish and poultry does not increase the risk of gestational diabetes, and consuming more vegetable and non-meat protein is associated with a reduction in risk. “For example, just over half a serving of nuts per day can reduce the risk of gestational diabetes by 40%.” “Based on current evidence, pregnant women or women planning to become pregnant should consider eating more vegetable protein, and nuts, and replacing some red meat with fish and poultry. (NEXT) Treatment for lupus may depend on restoring proteins in patients' blood Singapore General Hospital, December 19, 2022 Restoring protein balance in the blood may be key to developing an effective treatment for lupus. The incurable autoimmune disease reportedly affects about 100 in every 100,000 people worldwide, and disproportionally affects women between 15 and 45 years-old and Asians. Lupus causes the body's immune system to attack itself, which can inflame several vital organs like the kidneys, brain, heart, and lungs. The aggressive nature of the disease is what makes it life-threatening for many who have it, especially since current treatments don't help that much. “We are excited about the possibility of a new treatment option for lupus as 30 to 60 percent of patients do not respond to conventional medications despite aggressive regimens. In the past 65 years, only three drugs for lupus have been approved by the United States Food and Drug Administration but these drugs have modest efficacy. There is therefore a real and urgent need for better therapies, particularly for the more severe spectrum of lupus that we see in Asia,” says senior author Andrea Low, the Head and Senior Consultant in the Department of Rheumatology & Immunology at Singapore General Hospital (SGH), in a media release. To reach their findings, Low and her team studied CXCL5, a protein that helps to regulate the immune system through neutrophils, which are a type of white blood cell. They revealed that lupus patients had considerably lower levels of the protein in their blood compared to healthy people, thus suggesting that it may have a connection to the disease. They also discovered that mice with severe lupus injected weekly with CXCL5 displayed restored protein balance. Moreover, their survival outcomes increased from 25 percent to over 75 percent after 10 weeks. Not only did the injections reduce mortality risk, but they didn't cause any adverse side-effects, study authors report. “Our study has shown CXCL5 to be safe. There was no liver or kidney toxicity or cancer inducing effects. Major components of the immune system were also not compromised,” reports principal investigator Dr Fan Xiubo, Senior Research Fellow, Department of Clinical Translational Research, SGH. The entire team is hopeful that they can continue to build on their research to better the lives of patient's suffering from this debilitating disease. “To be in the forefront of medicine means we have to constantly further our understanding of diseases and offer patients better treatment options through rigorous scientific research. I'm heartened that the team has shed new light on lupus and the possibility of a more efficacious therapy for patients some years down the road,” says Professor Fong Kok Yong, Deputy Group CEO (Medical and Clinical Services), SingHealth, and Senior Consultant, Department Rheumatology & Immunology, SGH