Podcasts about WNT

TW - SA of a minor May 24th: Jesse Dirkhising Born (1986) Not everyone deserves your trust. On May 24th 1986 a young boy was born. A boy whose parents trusted two grown men with him. A deadly decision. https://en.wikipedia.org/wiki/Murder_of_Jesse_Dirkhising, https://www.allgaylong.com/blog/murder-jesse-dirkhising/, https://www.oddmurdersandmysteries.com/the-murder-of-jesse-dirkhising/, https://www.arkansasonline.com/news/2019/jun/08/judge-denies-new-dna-tests-for-child-ra/, https://abcnews.go.com/WNT/story?id=131125&page=1 Learn more about your ad choices. Visit megaphone.fm/adchoices

On Friday's Football Daily, Phil Egan brings you a full preview of this evening's League of Ireland action. We'll have live and exclusive coverage of St. Pats' Dublin derby with Shelbourne on tonight's Off The Ball, with coverage starting on Newstalk from 7pm. We hear from Pat's boss Stephen Kenny, Galway captain Greg Cunningham, Shamrock Rovers manager Stephen Bradley, Waterford forward Trae Coyle, Derry boss Tiernan Lynch and Sligo assistant Ryan Casey on tonight's top flight games. The FAI have strongly hit back at Kerry's claims of being 'bullied into silence'. Cobh Ramblers have moved to allay fears around their financial future. The Republic of Ireland. WNT have an afternoon appointment in Greece. And David Moyes responds to death threats aimed at Everton defender James Tarkowski.

On Friday's Football Daily, Phil Egan brings you a full preview of this evening's League of Ireland action. We'll have live and exclusive coverage of St. Pats' Dublin derby with Shelbourne on tonight's Off The Ball, with coverage starting on Newstalk from 7pm. We hear from Pat's boss Stephen Kenny, Galway captain Greg Cunningham, Shamrock Rovers manager Stephen Bradley, Waterford forward Trae Coyle, Derry boss Tiernan Lynch and Sligo assistant Ryan Casey on tonight's top flight games. The FAI have strongly hit back at Kerry's claims of being 'bullied into silence'. Cobh Ramblers have moved to allay fears around their financial future. The Republic of Ireland. WNT have an afternoon appointment in Greece. And David Moyes responds to death threats aimed at Everton defender James Tarkowski.

On Thursday's Football Daily, Phil Egan brings you all the reaction worth airing from the Merseyside derby. Liverpool skipper Virgil van Dijk speaks to OTB about their Premier League dreams, while David Moyes claims last night's winner should not have stood. PGMOL have reacted to James Tarkowski's contentious challenge on Alexis MacAllister. Amber Barrett discusses a potential 50th WNT cap. And the Women's World Cup is coming to Belfast.

On Thursday's Football Daily, Phil Egan brings you all the reaction worth airing from the Merseyside derby. Liverpool skipper Virgil van Dijk speaks to OTB about their Premier League dreams, while David Moyes claims last night's winner should not have stood. PGMOL have reacted to James Tarkowski's contentious challenge on Alexis MacAllister. Amber Barrett discusses a potential 50th WNT cap. And the Women's World Cup is coming to Belfast.

Join the lads as they talk about Finn Azaz perhaps making a move to South London, more games in June and the brand new WNT shirt is finally released and of course they take a look at how the Boys in Green got on across the water.

BUFFALO, NY - March 25, 2025 – A new #review was #published in Oncotarget, Volume 16, on March 13, 2025, titled “Signaling pathway dysregulation in breast cancer." In this review article, Dinara Ryspayeva and colleagues from Brown University provide a detailed look at how breast cancer cells change the way they communicate and grow—helping tumors survive, spread, and resist treatment. The review highlights how certain gene mutations and disrupted signaling pathways influence therapy response across different types of breast cancer. It also outlines current treatment strategies and clinical trials, offering insights that could improve care for patients with aggressive or hard-to-treat cancers. Breast cancer is the most common cancer in women and a major cause of cancer-related deaths worldwide. While many patients respond to treatment at first, some cancers return or stop responding. The review explores how signaling disruptions inside tumor cells are often behind these setbacks. The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These pathways help control cell growth, division, DNA repair, and survival. When altered by mutations or other changes, they can promote tumor progression and resistance to treatment. One of the most disrupted pathways is PI3K/Akt/mTOR. It plays a central role in cell growth, but in many breast cancers—especially hormone receptor-positive and HER2-positive types—it becomes overactive due to gene mutations, or the loss of a tumor-suppressing protein called PTEN. “Up to 25–40% of BC cases exhibit variations that hyperactivate the PI3K/Akt/mTOR pathway, underscoring its critical role in oncogenesis.” Another key pathway, RAS/RAF/MEK/ERK, can also promote tumor growth. Even without mutations, it may become active when primary pathways are blocked, particularly in HER2-positive and triple-negative breast cancers. The review also highlights several new and emerging treatments aimed at blocking down these signaling pathways. Some drugs are already approved, while others are in clinical trials. The authors suggest that combining different treatments may help stop multiple pathways at once, making it harder for cancer cells to adapt. Matching treatments to each tumor's unique genetic changes could also improve patient outcomes. This comprehensive review gives researchers and clinicians a clearer understanding of how breast cancer resists treatment and where future therapies should focus. A better understanding of these disrupted signaling systems could lead to more personalized and effective treatments for patients facing aggressive or recurring disease. DOI - https://doi.org/10.18632/oncotarget.28701 Correspondence to - Dinara Ryspayeva - dinara_ryspayeva@brown.edu Video short - https://www.youtube.com/watch?v=ppFVGwdztHI Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Stephen Kelly, Daryl Horgan and Richie Towell join Raf Diallo to react to Ireland's win over Bulgaria. The latter two reminisce about their Dundalk heyday and the reset at Oriel Park, while Shelbourne's Rachel Graham and RTÉ Sport's Anthony Pyne look ahead to the WNT squad announcement.

Welcome to Wednesday's OTB Breakfast Bite - your FREE bitesize taster of this morning's full Off The Ball Breakfast. On a packed show this morning, former Ireland defender Méabh de Búrca reviewed a disastrous evening for the WNT in Slovenia. GAA referee David Coldrick discusses the new rules in Gaelic football.Former Munster hooker Mike Sherry joins to talk Six Nations and more.And we were joined by Watford's on-loan defender James Abankwah. And that's where we take our Bite this morning, but not until after Ger and Colm address Ireland's terrible Women's Nations League result in Koper. Catch Off The Ball Breakfast LIVE weekday mornings from 7:30am or just search for Off The Ball Breakfast and get the podcast on the Off The Ball app. SUBSCRIBE at OffTheBall.com/join

Welcome to Wednesday's OTB Breakfast Bite - your FREE bitesize taster of this morning's full Off The Ball Breakfast. On a packed show this morning, former Ireland defender Méabh de Búrca reviewed a disastrous evening for the WNT in Slovenia. GAA referee David Coldrick discusses the new rules in Gaelic football.Former Munster hooker Mike Sherry joins to talk Six Nations and more.And we were joined by Watford's on-loan defender James Abankwah. And that's where we take our Bite this morning, but not until after Ger and Colm address Ireland's terrible Women's Nations League result in Koper. Catch Off The Ball Breakfast LIVE weekday mornings from 7:30am or just search for Off The Ball Breakfast and get the podcast on the Off The Ball app. SUBSCRIBE at OffTheBall.com/join

On Friday's Football Daily, Phil Egan helps preview tonight's Women's Nations League clash of the Republic of Ireland and Türkiye at Tallaght Stadium. Ahead of that game, Katie McCabe has blasted the FAI's treatment of Colin Healy as 'not good enough', we speak to the skipper. And new WNT manager Carla Ward's view of the domestic game seems to be at odds with MNT counterpart Heimir Hallgrimsson. Nathan catches up with Stephen Bradley following Shamrock Rovers Conference League exit. And we hear from Stephen Kenny, Greg Cunningham and Tiernan Lynch ahead of tonight's Premier Division fixtures. Don't forget, Galway United's clash with St. Pat's is LIVE & EXCLUSIVE on tonight's Off The Ball.

On Friday's Football Daily, Phil Egan helps preview tonight's Women's Nations League clash of the Republic of Ireland and Türkiye at Tallaght Stadium. Ahead of that game, Katie McCabe has blasted the FAI's treatment of Colin Healy as 'not good enough', we speak to the skipper. And new WNT manager Carla Ward's view of the domestic game seems to be at odds with MNT counterpart Heimir Hallgrimsson. Nathan catches up with Stephen Bradley following Shamrock Rovers Conference League exit. And we hear from Stephen Kenny, Greg Cunningham and Tiernan Lynch ahead of tonight's Premier Division fixtures. Don't forget, Galway United's clash with St. Pat's is LIVE & EXCLUSIVE on tonight's Off The Ball.

BUFFALO, NY – February 14, 2025 – A new #review was #published in Oncotarget, Volume 16, on February 12, 2025, titled “SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types.” Authors Elodie Verdier, Nathalie Gaspar, Maria Eugenia Marques Da Costa, and Antonin Marchais from the Gustave Roussy Cancer Campus analyzed recent studies on a gene called SETDB1, which may play a key role in osteosarcoma, a type of bone cancer that mostly affects teenagers and young adults. Their review highlights how SETDB1 helps cancer cells grow, resist treatment, and avoid the immune system. Because of this, blocking SETDB1 could be a promising new way to treat osteosarcoma. Osteosarcoma is a fast-growing bone cancer that is usually treated with surgery and chemotherapy. However, if the cancer spreads or returns, treatment options are very limited. Scientists are searching for new ways to stop this disease, and recent studies have found that osteosarcoma cells often have extra copies of the SETDB1 gene. This seems to make the cancer more aggressive and harder to treat. “Whole exome sequencing of osteosarcoma samples from both diagnosis and relapses has highlighted several factors, including SETDB1, that are amplified in the most aggressive forms of the disease.” SETDB1 is involved in epigenetics, meaning it affects how genes are turned on and off without changing the DNA itself. The review explains that SETDB1 helps tumors hide from the immune system, making it difficult for the body to fight the cancer naturally. The researchers believe that blocking SETDB1 could help the immune system recognize and attack osteosarcoma cells. Some experimental drugs that target SETDB1 are already being tested in the lab. The review also describes how SETDB1 influences key cancer pathways, such as Wnt signaling, which helps cancer cells grow, and epithelial-mesenchymal transition (EMT), a process that allows cancer to spread. The authors suggest that combining SETDB1-blocking drugs with immunotherapy or radiation could be an effective new strategy for treating osteosarcoma. Another key finding is that SETDB1 may help cancer cells become resistant to chemotherapy, making treatment less effective. This means that drugs targeting SETDB1 could not only slow cancer growth but also make existing treatments work better. While more research is needed, this review brings attention to SETDB1 as a potential treatment target. Scientists hope that a deeper understanding of SETDB1 will lead to new therapies that improve survival rates for osteosarcoma patients. DOI - https://doi.org/10.18632/oncotarget.28688 Correspondence to - Antonin Marchais - antonin.marchais@gustaveroussy.fr, and Maria Eugenia Marques Da Costa - jenny.marquescosta@gustaveroussy.fr Video short - https://www.youtube.com/watch?v=f9WgaDoEubs About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

On Wednesday's Football Daily, Phil Egan brings you details of Mason Melia's blockbuster move to Tottenham, and what it means for St. Pat's. Denise O'Sullivan has strongly criticised the FAI's treatment of former WNT assistant Colin Healy. Bohemians are weighing up a move for former Premier League striker Lys Mousset, and we hear from another of their arrivals - Connor Parsons. Arne Slot discusses Conor Bradley replacing Trent Alexander-Arnold for Liverpool in the Carabao Cup. And Adam Idah is ready to take on more responsibility at Celtic.

On Wednesday's Football Daily, Phil Egan brings you details of Mason Melia's blockbuster move to Tottenham, and what it means for St. Pat's. Denise O'Sullivan has strongly criticised the FAI's treatment of former WNT assistant Colin Healy. Bohemians are weighing up a move for former Premier League striker Lys Mousset, and we hear from another of their arrivals - Connor Parsons. Arne Slot discusses Conor Bradley replacing Trent Alexander-Arnold for Liverpool in the Carabao Cup. And Adam Idah is ready to take on more responsibility at Celtic.

In case you missed it, here is episode one from our Settle In Series, as a bonus listen for all of our GAA Fans!Former Ireland international and coach Linda Gorman joined Eoin Sheahan to discuss how she's tackling ageism in sport by encouraging more people to take up walking football and she also discussed how much support for the women's game in Ireland has changed since she played on the first ever WNT over 50 years ago.‘Settle in' in partnership with Guinness 0.0.

In case you missed it, here is episode one from our Settle In Series, as a bonus listen for all of our GAA Fans! Former Ireland international and coach Linda Gorman joined Eoin Sheahan to discuss how she's tackling ageism in sport by encouraging more people to take up walking football and she also discussed how much support for the women's game in Ireland has changed since she played on the first ever WNT over 50 years ago.‘Settle in' in partnership with Guinness 0.0.

Former Ireland international and coach Linda Gorman joined Eoin Sheahan to discuss how she's tackling ageism in sport by encouraging more people to take up walking football and she also discussed how much support for the women's game in Ireland has changed since she played on the first ever WNT over 50 years ago.‘Settle in' in partnership with Guinness 0.0.

rWotD Episode 2794: Cerberus (protein) Welcome to Random Wiki of the Day, your journey through Wikipedia’s vast and varied content, one random article at a time.The random article for Friday, 27 December 2024 is Cerberus (protein).Cerberus is a protein that in humans is encoded by the CER1 gene. Cerberus is a signaling molecule which contributes to the formation of the head, heart and left-right asymmetry of internal organs. This gene varies slightly from species to species but its overall functions seem to be similar.Cerberus is secreted by the anterior visceral endoderm and blocks the action of BMP, Nodal and Wnt, secreted by the primitive node, which allows for the formation of a head region. This is accomplished by inhibiting the formation of mesoderm in this region. Xenopus Cerberus causes a protein to be secreted that is able to induce the formation of an ectopic head. Knockdown experiments have helped to explain Cerberus's role in both the formation of the head and left and right symmetry. These experiments have shown that Cerberus helps to keep Nodal from crossing to the right side of the developing embryo, allowing left and right asymmetry to form. This is why misexpression of Cerberus can cause the heart to fold in the opposite direction during development. When Cerberus is “knocked down” and BMP and Wnt are up regulated the head does not form. Other experiments using mice that this gene has been “knocked out” showed no head defects, which suggest that it is the combination of the up regulation of BMP and Wnt along with the absence of Cerberus that causes this defect. For the heart, Cerberus is one of several factors that inhibits Nodal to initiate cardiomyogenic differentiation The Cerberus gene family produces many different signal proteins that are antagonistically involved in establishing anterior-posterior patterning and left-right patterning in vertebrate embryos.This recording reflects the Wikipedia text as of 01:18 UTC on Friday, 27 December 2024.For the full current version of the article, see Cerberus (protein) on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Mastodon at @wikioftheday@masto.ai.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm generative Ruth.

The prospect of a minimally toxic, chemotherapy-free cure for hepatoblastoma is held out by findings from a mouse model using the small-molecule drug WNTinib that inhibits the Wnt signaling pathway involved with cancer growth. Lead author Ugnė Balaševičiūtė, a pre-doctoral researcher in Translational Research of the Hepatic Oncology Group led by Josep M. Llovet, Professor at the Institut D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS) in Barcelona, Spain, reported that the CTNNB1 (catenin beta-1 protein) gene targeted by WNTinib was expressed in 90 percent of all hepatoblastomas. Hopes were high that a safer alternative to chemotherapy in humans was on the way.

Episode #151 - Beat Salad :))))Playlist: NIghtmares on Wax - Les Nuits (Carboot Jazz Full Length)Jeff Parker, ETA IVtet - Late AutumnBill Evans, Jim Hall - I'm Gettin' Sentimental Over YouJazzbois - enter wandsbekColossus - The What?!Jazz Liberatorz - I Am Hip Hop (feat. Asheru)Datsunn - Extra Love (feat. Munch)Henkel - Truth and LiesKurious - Tis The Seasonkawfee - IT.JUS.WNT.DOBADBADNOTGOOD - First Lovevbnd, The Soulmate Collective - In a Fugue StateRahsaan Roland Kirk - Volunteered SlaveryO'Donel Levy - Bad, Bad SimbaSpectacular Diagnostics - WHYWEDOITELWD - Ghost Dog FlowRobohands - ThermaeNxWorries - KeepHer (feat. Thundercat)

On Friday's Football Daily, Phil Egan brings you reaction to Shamrock Rovers' invaluable point in the Conference League, as we hear from Stephen Bradley. Ruben Amorim admits his Manchester United players are giving him anxiety. Eileen Gleeson and Denise O'Sullivan speak ahead of tonight's vital Euro playoff for Ireland's WNT in Cardiff. And we hear from new Coventry manager Frank Lampard.

On Friday's Football Daily, Phil Egan brings you reaction to Shamrock Rovers' invaluable point in the Conference League, as we hear from Stephen Bradley. Ruben Amorim admits his Manchester United players are giving him anxiety. Eileen Gleeson and Denise O'Sullivan speak ahead of tonight's vital Euro playoff for Ireland's WNT in Cardiff. And we hear from new Coventry manager Frank Lampard.

Former Ireland international and coach Linda Gorman joined Eoin Sheahan to discuss how she's tackling ageism in sport by encouraging more people to take up walking football and she also discussed how much support for the women's game in Ireland has changed since she played on the first ever WNT over 50 years ago.‘Settle in' in partnership with Guinness 0.0.

The term ‘one-stop-shop' is often banded around the subcontract manufacturing industry. It's not until you find a company like Woodbrook Precision Ltd that you can truly understand what a single source solution provider looks like. The Lancashire manufacturer ventures beyond rivals' services and continually invests in the latest machine tools fully supported by advanced cutting tool solutions from CERATIZIT UK. The company is located in Ashton-Under-Lyne on the Northeast edge of Greater Manchester. It's plant list includes a complete array of manual and CNC 3 to 5-axis machining centres and multi-axis turning centres from renowned brands such as Mazak, XYZ, Leadwell and Bridgeport. The state-of-the-art plant list is supported by services such as grinding, plating, shearing, profiling, welding, laser cutting, gear cutting, heat treatment, powder coating and more. Rightly proud of its comprehensive services and recent investment in Mazak machine tools, Managing Director Stephen Hogg from Woodbrook Precision says that CERATIZIT has been instrumental in enhancing the productivity of the new equipment. The second-generation business was founded by Stephen's father more than 35 years ago. When Stephen bought the company 16 years ago, Woodbrook operated out of a small unit with a single CNC turning centre and a series of manual mills—all supported by various cutting tool vendors, with WNT (a member of the CERATIZIT Group) being one of the many. However, as Stephen has applied his vision and determination to the company, Woodbrook has evolved with a 2018 move to an 18,000sq/ft facility three times larger than the previous site. Plans are also afoot to add another 10,000sq/ft. This growth has stemmed from the business's progress in general subcontract machining into the oil & gas, aerospace, rail, and motorsport sectors. Woodbrook has evolved the sophistication of its machine tool purchases to serve these industries. Initially investing in 3-axis Mazak VMCs with rotary tables and turning centres with live tooling, more recent acquisitions have included two 3.5m bed Mazak VTC800/30SR 5-axis machines and a 5-axis Mazak CV5-500. This has seen work for overhead cranes, rail, and general subcon evolve to aerospace jigs and fixtures, critical subsea valves and manifolds, motorsport brake callipers, engine components and more. With an evolution driven by the expanding capabilities of its machine tools, Woodbrook has needed to rely more heavily on the expertise of its cutting tool suppliers. As the business has shifted from machining steel and aluminium to stainless, super duplex, titanium, inconel, carbon fibre, hastelloy and much more – CERATIZIT UK has risen through the ranks to be the cutting tool partner of choice. Stephen Hogg from Woodbrook says: “Over ten years ago, CERATIZIT was one of many suppliers, and as I took control of the business. It became evident that CERATIZIT had the best-performing tools and their service was far beyond anything else. As we continually ventured into more complex work and more challenging materials, we needed greater support and new machining strategies. CERATIZIT UK's Technical Sales Engineer Matthew Darbyshire has been with us all the way to provide the solution. It's been seamless, and it's pointless going elsewhere as Matt makes it so easy and ‘painless' for us.” “With numerous sales reps continually calling upon us, we asked Matt for a few tools to trial. The tools initially performed well, but for the relationship to blossom to a position where we now have thousands of CERATIZIT tools. This has been built on tool performance, product range diversity, supply chain continuity and most importantly, technical support, service and trust that has instantly been available. I can WhatsApp Matt with any drawings and queries and he'll deliver a solution imminently.” As a machine shop that typically manufactures prototypes in small batches, tracking continuous tooling improvement isn't always the priority for Woodbrook. However, you don't have to look far for quantifiable results with CERATIZIT products. Stephen says: “We recently implemented the CERATIZIT facing and parting-off tools, and it reduced the cycle time on a 400-off job from 1 minute 58 seconds to 1 minute 26 seconds. We also applied the Dragonskin CircularLine DLC-coated solid carbide end mills with impressive results. The Dragonskin tools have cut cycle times on an aluminium part from 3 minutes to 1 minute 20 seconds whilst more than doubling our tool life.” “On another 100-off repeat order stainless steel aerospace fixture, we needed to reduce our cycle times to maximise margins and reduce costs. Matt introduced a CERATIZIT UK high feed indexable end mill, and this reduced our cycle times from 38 to 26 minutes per part, with a tool life improvement of more than 20%. This was a significant saving on a long-running job.” However, the most significant saving wasn't from the cutting tools…. With the 100-off stainless job running through the business frequently, Woodbrook set up six vices in a line on the spacious 3.5m bed of its Mazak 5-axis VTC800/30SR. When each surface and cycle was completed, an operator would re-set the job to process the next face. With a total of four operations, the process was laborious. Stephen spoke with Matt from CERATIZIT, and the way forward was a bespoke workholding solution that was ‘Made in Sheffield' at the CERATIZIT UK Technical Centre and Headquarters. Stephen visited the CERATIZIT stand at MACH 2024. He realised that the only cost for CERATIZIT's bespoke service was the price of the aluminium tombstone billet and the cost of the four ZSG4-125 Centric vices that connect to the zero-point single riser tombstone system. Immediately impressed, Woodbrook Precision ordered a pyramid system to clamp smaller parts in its 5-axis Mazak CV5-500. The ZSG4-125 Centric vices with serrated jaws enabled Woodbrook to clamp on as little as 3mm of stock, permitting the subcontractor to hit all five sides of the stainless parts with confidence in the high-torque clamping forces of the vice. With five faces machined in a single operation, the following operation was to turn the parts over to complete the sixth surface. This reduced this 100-off repeat job from a four to a two-operation process, saving an additional 10 minutes per part. Stephen says: “This job took over one hour per part from start to finish. The tombstone and Centric ZSG vices immediately took more than 10 minutes off each part, with peripheral savings being longer running times without operator intervention. Reduced set-ups also improved our precision, repeatability and consistency over an entire batch of parts. We work 12 hours a day, six days a week, and the tombstone enabled us to set up a batch of four parts at the end of a shift to run unmanned for a couple of hours – giving us further savings.” “We're now using CERATIZIT for everything from our back-ends and collets to solid carbide and indexable tools ranging from drills and threadmills to end mills, turning and parting tools. We never thought we'd be turning to CERATIZIT for our workholding solutions, but just like the cutting tools – the quality and performance of the workholding solutions that come with a ‘Made in Sheffield' brand is far superior to anything else we've encountered.”

On this episode of the Modern Facilities Management Podcast, Griffin Hamilton interviews Yaron Dycian from Wint.AI, discussing the critical issues of water management in buildings. They explore the significant waste of water, the financial implications of leaks, and how Wint leverages AI for anomaly detection and predictive analytics to optimize water usage. The conversation also touches on proactive measures facilities managers can take and the future of water management technology in buildings.Chapters00:00Introduction to Wnt and Water Management03:01The Impact of Water Waste05:55Leveraging AI for Water Management09:00Insights and Analytics in Water Usage12:04Proactive Measures for Water Management14:59Future of Water Management in Facilities17:57Career Influences and Closing ThoughtsInterested in closing the skills gap? Check out our friends at Interplay Learning!

Vitamin D is not a vitamin; it's a hormone intimately involved in 10% of our genes. If you don't have enough vitamin D, it can interfere with the genes responsible for hair growth. There is also a very high concentration of vitamin D receptors in the hair follicle. Without enough vitamin D, your immune system is at risk of autoimmune conditions, including alopecia. Vitamin D supports the T cells that help combat autoimmune diseases. Psoriasis, dandruff, and dermatitis are also related to low vitamin D. Magnesium is the most potent regulator of calcium and is involved with enzymes important for hair health. It's also essential for the proper function of vitamin D. There are 2 systems of vitamin D: one that controls calcium and one that has several functions, including hair growth and hair restoration. This form of vitamin D has a 24-hour half-life, so you need daily sun or supplements to prevent a hair loss problem. There is a worldwide vitamin D deficiency epidemic! Several factors contribute to this massive vitamin D deficiency problem, including genetics, skin color, insulin resistance, diabetes, obesity, and air pollution. Your blood vitamin D levels should be at least 70 to 100 ng/mL. You need at least 20,000 IU of vitamin D daily and 50 mg of magnesium to support hair growth. Zinc, iron, vitamin B12, and omega-3 fatty acids are also essential for hair restoration. Key genes involved in hair growth: 1. Sonic Hedgehog (SHH) gene 2. WNT genes 3. BMP (Bone Morphogenetic Protein) genes 4. FGF (Fibroblast Growth Factor) genes 5. TGF-β (Transforming Growth Factor-Beta) genes 6. LEF1 (Lymphoid Enhancer-Binding Factor 1) 7. PDGF (Platelet-Derived Growth Factor) 8. Dkk (Dickkopf WNT Signaling Pathway Inhibitor) genes 9. CTNNB1 (Beta-Catenin)

Bart drops by to talk all the NT talk- USYNT and the U20 loss in Mexico, the USMNT losing in the knockouts in Paris and the WNT continuing to chase a medal under Emma Hayes

Ryan and Graham are here to deliver an update on the US teams at Paris 2024! It's the end of the road for the men, whose limitations were exposed by Morocco, while the WNT survived a technical battle with Japan to progress! JOIN THE TSS+ PATREON! Check out our Patreon, which houses bonus podcasts, access to our exclusive Discord, blog posts, videos, and much more. Become a member today at patreon.com/totalsoccershow! Learn more about your ad choices. Visit megaphone.fm/adchoices

Ryan and Graham are here to deliver an update on the US teams at Paris 2024! It's the end of the road for the men, whose limitations were exposed by Morocco, while the WNT survived a technical battle with Japan to progress!JOIN THE TSS+ PATREON!Check out our Patreon, which houses bonus podcasts, access to our exclusive Discord, blog posts, videos, and much more.Become a member today at patreon.com/totalsoccershow! Hosted on Acast. See acast.com/privacy for more information.

Belz, Vince and Tara recap the 2-1 win over Australia. Not as cathartic as the win over Germany, but still lots to celebrate, plenty to nitpick. The WNT and Emma Hayes have given us a nine-point window! So we had to dust off an old number for the intro to this episode. Subscribe to Scuffed on Patreon! Patrons get a private ad-free feed for all episodes that go out on the public feed, plus the Monday Review every week with Watke and Vince. Patrons also get access to our private Discord server, live call-in shows, and the full catalog of historic recaps we've made: https://www.patreon.com/scuffed

Dr. Shukry Habib is an Associate Professor in the Department of Biomedical Sciences at the Université de Lausanne. His lab works at the intersection of stem cell biology, biophysics, and tissue engineering to investigate how tissues form. He talks about developing a transplantable bandage for bone repair and the role of Wnt signaling and cytonemes in development.

We discuss remarkable preliminary results from the the use of intravitreal EYE-103, a novel Wnt pathway agonist in the treatment of DME and neovascular AMD with Dr. Charles Wykoff of Houston Texas.

In this episode of Behind the Business, founder Niamh Tallon and co-founder Mohammed Mahommed sat down to chat about what the Her Sport team has been up to over the past few months! From the team expanding to reflecting on women's sport in 2023, join Niamh and Mohammed as they share the exciting developments, upcoming projects and new goals for the business. 0:19 Update on the #hersport team 3:18 What is the Going For Growth Programme? 7:26 Her Sport's rapid social growth 9:16 Like & Subscribe 12:20 Womens sport in 2023 14:50 FIFA 2023 Women's World Cup 18:00 Ireland's WNT playing at the Aviva 24:40 New campaigns 27:19 #DOITFORHER 30:22 What is the aim of Her Sport? 33:28 Being a Her Sport MVP 40:00 The value of education 47:29 Expanding the Her Sport Workshops 51:13 What is the Her Sport Awards? 56:59 How you can help us Visit the website https://hersport.ie/ Check out the Her Sport channels Instagram - https://www.instagram.com/hersport.ie Facebook - https://www.facebook.com/HerSport.ie/ Twitter - https://twitter.com/HerSportDotIE About Her Sport: Her Sport is a media platform centred on bringing the latest Irish and international women's sports news. Her Sport aims to empower women in sport, inspire more female participation, increase opportunity and level the playing field for future generations. Our objective is to create real and tangible change. Contact us: hello@hersport.ie

Peter and Alex gather at the west-coast NFP Studios to recap an incredible night at Christine Sinclair Place on Tuesday night, including the future of the CanWNT and whether the CSA should prioritize BC Place as a venue for future matches. They also discuss York United's new ownership, burning listener questions about the MNT's future and Wilfried Nancy's stock after reaching the MLS Cup Final with the Columbus Crew. FOLLOW US ON SOCIAL: Northern Fútbol: @NorthernFutbol Peter Galindo: @GalindoPW Alex Gangué-Ruzic: @AlexGangueRuzic Ben Steiner: @BenSteiner00 RUNNING ORDER: 2:41 – That Christine Sinclair Place atmosphere

Reunited for the holiday Friendsgiving episode is Greggo and TK and at long last the ladies of Shea Butter FC, coming back a trip down the road to San Diego for the NWSL Championship which saw Gotham claim their first NWSL chip over a fallen Megan Rapinoe and OL Reign. We recap their Championship Week experience and coming to glances with famous beefs, and the re-emergence of Midge Purce on the big stage.We also come off the big announcement by US Soccer naming Chelsea Head Coach Emma Hayes their new WNT Coach, and what this means for the WNT going forward and also how such a big hire affects the men's side as well. FTC also hits up the opening rounds of the MLS playoffs, and in 2UP/2down we get on the end of the Hollywood strikes, the Falcons and Raiders, the NBA In-Season Tournament, and more!Follow us on social media!Twitter, Instagram, and Facebook and now Threads @FTCUTD!!TikTok @ftcutdpod!Get 10% Off with the code CULTURE10 at ftcutd.com/shop, good thru Thanksgiving weekend! Hosted on Acast. See acast.com/privacy for more information.

Ben, Peter and Alex recap a wild Sunday in Vancouver between the Whitecaps and LAFC, dive into the Caps' post-morterm, break down the WNT's win over Brazil, preview the U-17 World Cup for Canada and answer some of your pertinent questions on all things Canadian footy! FOLLOW US ON SOCIAL: Northern Fútbol: @NorthernFutbol Ben Steiner: @BenSteiner00 Peter Galindo: @GalindoPW Alex Gangué-Ruzic: @AlexGangueRuzic RUNNING ORDER: 3:48 – Atmosphere at BC Place for a packed Whitecaps game 10:54 – What on earth was that officiating?! 21:30 – Was a Whitecaps elimination by LAFC inevitable? 29:12 – How do the Whitecaps improve their squad to reach the next level? 35:59 – Where should the Whitecaps add a DP? 41:09 – How will Vancouver approach the striker position? 44:32 – Canada vs. Brazil takeaways 49:03 – Canadian U-17 World Cup preview 53:03 – Breaking down Luc De Fougerolles' Fulham debut 57:08 – Potential roster surprises for CanMNT 59:02 – Will Loturi, Paton or Bair crack the roster? 1:00:24 – How CPL can maintain its momentum from the final 1:03:36 – What direction will York United take under new ownership? 1:07:07 – When will expansion news come for the CPL? 1:10:31 – Does James Cameron have real potential? 1:13:18 – U-20 players to watch

Greg, Vince, Tara and Belz talk through the surprise of the weekend, first reported by Joe Lowery at Backheeled, that Chelsea manager and arguably the best coach in women's soccer Emma Hayes has agreed to terms with the USSF to coach the women's national team. We talk about her background, her ideas about American soccer development, the ways she is likely to manage the WNT and the as yet unclear transition for her from Chelsea to USA.https://twitter.com/Backheeled Subscribe to Scuffed on Patreon! Patrons get a private feed for the Monday Review, which is, among other things, a run-down of club action for national team players every week with Watke and Vince. We have recently added patron-only content that's available every Friday. Patrons also get access to our private Discord server, live call-in shows, and the full catalog of historic recaps we've made: https://www.patreon.com/scuffed

The USA Soccercast is back with Episode 117, as we get ready for the USWNT's matches against Colombia this weekend as well as dip into the mailbag. The USWNT take on Colombia twice this weekend, with the first one coming tonight in Salt Lake City. We quickly preview the matchup, the USWNT roster, and a few players from Las Cafeteras that fans should pay attention to when they hit the field. These matches are important as we start to see who tries to separate themselves and show they should be on the shortened roster for the Olympics next summer. After the break, we dip into the mailbag for a great question: who is your all-time USWNT gameday roster? That includes the starting XI and your bench. We go through each position in the starting XI and also who would make the bench. Of course, we want to know who your all-time WNT roster would be, so chime in on Twitter or via email! Also, don't forget to follow us on Twitter and to tap into our Linktree, which will give you access to all our affiliate links: Fanatics, Homage, BreakingT, and the MLS Store. Fall is coming, which means a great chance to get some new stuff. Now, you'll be able to save some money on all the cool soccer apparel or anything else you're interested in wearing! And finally, tag us on Twitter or email USA Soccercast at Gmail dot com with any topic suggestions or questions for the show. We'd like to have a mailbag episode, and we could use your questions! Learn more about your ad choices. Visit megaphone.fm/adchoices

SoccerForUSPod's Bart Keeler drops by to talk about the international window from the US perspective (MNT, YNT, WNT) and we get our weekly run of reffingdownhere looking at the job and the decisions of the week... Here's the segment in its entirety from SDH

It's a busy SDHWall Pass Wednesday brings in coaching carousel and the new job for Wayne RooneyHour 2 brings Dylan Butler in to talk MLS and SoccerForUSPod's Bart Keeler drops by to talk about the international window from the US perspective (MNT, YNT, WNT) and we get our weekly run of reffingdownhere looking at the job and the decisions of the week...

SoccerForUSPod's Bart Keeler drops by to talk about the international window from the US perspective (MNT, YNT, WNT) and we get our weekly run of reffingdownhere looking at the job and the decisions of the week...Here's the segment in its entirety from SDH

It's a busy SDH Wall Pass Wednesday brings in coaching carousel and the new job for Wayne Rooney Hour 2 brings Dylan Butler in to talk MLS and SoccerForUSPod's Bart Keeler drops by to talk about the international window from the US perspective (MNT, YNT, WNT) and we get our weekly run of reffingdownhere looking at the job and the decisions of the week...

It's just Kathleen & Karen this week as Emma attends to some very important WNT business... but we've still got all the usual WSL analysis you could hope for, as well as the Team of the Week!The COYGIG Pod on Off The Ball is in association with Cadbury, the official snack partner to the Republic of Ireland's Women's National Team.#CadburySupporterAndAHalf | Cadbury Ireland

Stephen Doyle and Kathleen McNamee react to the Republic of Ireland's WNT's first-ever game at the Aviva which resulted in a 3-0 win over Northern Ireland. Football on Off the Ball with William Hill Ireland.

Jenny Chiu, Lisa Carlin, Jordan Angeli and Darian Jenkins react to Midge Purce and M.A. Vignola's late additions to the USWNT roster (01:41) and the RFEF giving Spain's WNT players an ultimatum about returning to international duty (04:56). Then, a recap of another weekend of twists and turns in NWSL beginning with the Esther González Show in NY/NJ Gotham's win over Washington Spirit (08:59). We hear from Chicago Red Stars and Canada defender Bianca St-Georges about overcoming physical and mental setbacks (22:23). With three matchdays to go in NWSL regular season, the crew make their playoff predictions (31:33). And a look at the must-see matchups in the upcoming international break (40:55). Watch USWNT, NWSL and WSL games on P+" with a link to https://www.paramountplus.com/home/ Attacking Third is available for free on the Audacy app as well as Apple Podcasts, Spotify, Google Podcasts, Stitcher and wherever else you listen to podcasts.  Follow the Attacking Third team on Twitter: @AttackingThird, @SandHerrera_, @LisaCarlin32, @Jordangeli , @JennyaChiu and @Darian_Jenks. Visit the Attacking Third YouTube channel: https://www.youtube.com/attackingthird You can listen to Attacking Third on your smart speakers! Simply say "Alexa, play the latest episode of the Attacking Third podcast" or "Hey Google, play the latest episode of the Attacking Third podcast." For more soccer coverage from CBS Sports, visit https://www.cbssports.com/soccer/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Jenny Chiu, Lisa Carlin, Christine Cupo and Darian Jenkins discuss the latest out of Spain as the federation has fired WNT head coach Jorge Vilda and Jenni Hermoso has spoken out. They preview the Challenge Cup semifinals giving tactical breakdowns. Sandra Herrera joins to share her players to watch. Watch Attacking Third for FREE, live Golazo Network every Monday, Wednesday and Friday at 4pmET on Paramount+ or the CBS Sports App. Watch USWNT, NWSL and WSL games on P+" with a link to https://www.paramountplus.com/home/ Attacking Third is available for free on the Audacy app as well as Apple Podcasts, Spotify, Google Podcasts, Stitcher and wherever else you listen to podcasts.  Follow the Attacking Third team on Twitter: @AttackingThird, @SandHerrera_, @LisaCarlin32, @Jordangeli , @JennyaChiu and @Darian_Jenks. Visit the Attacking Third YouTube channel: https://www.youtube.com/attackingthird You can listen to Attacking Third on your smart speakers! Simply say "Alexa, play the latest episode of the Attacking Third podcast" or "Hey Google, play the latest episode of the Attacking Third podcast." For more soccer coverage from CBS Sports, visit https://www.cbssports.com/soccer/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

In this episode of the Epigenetics Podcast, we talked to Claudio Cantù from Linköping University about his work on peak blacklists, peak concordance and what is a peak in CUT&RUN. Our host Stefan Dillinger and guest Claudio Cantù dive into the topic of when we can be sure that a peak is a peak. To help with this, Claudio Cantù's group has been working on defining a set of suspicious peaks that can be used as a "peak blacklist" and can be subtracted to clean up CUT&RUN data sets. The lab also worked on a method called ICEBERG (Increased Capture of Enrichment By Exhaustive Replicate aGgregation) to help define peaks from a number of experimental replicates. By using this algorithm, the team is trying to discover the beta-catenin binding profile, not the tip of the beta-catenin binding iceberg, but the whole of the beta-catenin binding profile.   References Zambanini, G., Nordin, A., Jonasson, M., Pagella, P., & Cantù, C. (2022). A new CUT&RUN low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/β-catenin tissue-specific genomic targets. Development (Cambridge, England), 149(23), dev201124. https://doi.org/10.1242/dev.201124 Nordin, A., Zambanini, G., Pagella, P., & Cantù, C. (2022). The CUT&RUN Blacklist of Problematic Regions of the Genome [Preprint]. Genomics. https://doi.org/10.1101/2022.11.11.516118 Nordin, A., Pagella, P., Zambanini, G., & Cantu, C. (2023). Exhaustive identification of genome-wide binding events of transcriptional regulators with ICEBERG [Preprint]. Genomics. https://doi.org/10.1101/2023.06.29.547050   Related Episodes Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff) Single Cell Epigenomics in Neuronal Development (Tim Petros)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

Biden is a proven traitor. Kevin McCarthy must impeach him or the Freedom Caucus must remove McCarthy. A Deep DiveIt's pass or fail for McCarthy AND the Freedom Caucus (we already know where McConnell stands -- with Biden's Crime Family). Either Kevin McCarthy and the House GOP vote to Impeach Biden or the Freedom Caucus votes to vacate the Speaker's Chair. Why?Massive election rigging. Obstruction of Justice.Taking bribes.Garland must be removed. Why?All the same reasons, plus lying to Congress. What does God's Word say? Psalm 52:1-7Why do you boast of evil, you mighty hero? Why do you boast all day long, you who are a disgrace in the eyes of God?2 You who practice deceit, your tongue plots destruction; it is like a sharpened razor.3 You love evil rather than good, falsehood rather than speaking the truth.[c]4 You love every harmful word, you deceitful tongue!5 Surely God will bring you down to everlasting ruin: He will snatch you up and pluck you from your tent; he will uproot you from the land of the living.6 The righteous will see and fear; they will laugh at you, saying,7 “Here now is the man who did not make God his strongholdbut trusted in his great wealth and grew strong by destroying others!”1 Corinthians 5:11 - (WNT means the Weymouth New Testament, known also as The New Testament in Modern Speech or The Modern Speech New Testament. It is a translation into "modern" English used in the nineteenth century from the base-text of The Resultant Greek Testament by Richard Francis Weymouth.)“But what I meant was that you were not to associate with any one bearing the name of "brother," if he was addicted to fornication or avarice or idol-worship or abusive language or hard-drinking or greed of gain. With such a man you ought not even to eat.”Episode 918 Links:Whistleblower Transcripts Show Deep-State Election Rigging For Biden Was Way Bigger Than A LaptopAG Garland promised the American people in public testimony the prosecutor handling Hunter Biden's case, U.S. Attorney for Delaware David Weiss, could bring charges against Hunter Biden outside of Delaware.WaysandMeansGOP just voted to release 14 hours of transcribed interviews with 2 IRS whistleblowers. Their story of how the federal government handled an investigation into a “high-profile individual” is stunning. READ:Remember where this all started who who ran the op: Explosive New FBI Notes Confirm Obama Directed Anti-Flynn Operation, By: Sean Davis And Mollie Hemingway, June 24, 2020White House National Security Council Coordinator WALKS OUT after being asked about Hunter Biden's WhatsApp messages with China implicating President BidenIRS investigators wanted to search a Virginia storage unit controlled by Hunter Biden, where he stored files & documents. DOJ prosecutors went and tipped off Hunter's lawyers.Statement from IRS Agent Gary Shapley's legal team: "In an October 7, 2022, meeting at the Delaware U.S. Attorney's Office, U.S. Attorney David Weiss told six witnesses he did not have authority to charge in other districts and had thus requested special counsel status. Those six witnesses include Baltimore FBI Special Agent in Charge Tom Sobocinski and Assistant Special Agent in Charge Ryeshia Holley, IRS Assistant Special Agent in Charge Gary Shapley and Special Agent in Charge Darrell Waldon, who also independently and contemporaneously corroborated Mr. Shapley's account in an email, now public as Exhibit 10, following p. 148 of his testimony transcript. Mr. Shapley would have no insight into why Mr. Weiss would make these statements at the October 7, 2022 meeting if they were false. That Mr. Weiss made these statements is easily corroborated, and it is up to him and the Justice Department to reconcile the evidence of his October 7, 2022 statements with contrary statements by Mr. Weiss and the Attorney General to Congress."Hunter's Attorney: “Hunter Biden attorney responds to IRS agent testimony - and refers to 2017 message suggesting Joe Biden proximity to China deal: "Any verifiable words or actions of my client, in the midst of a horrible addiction, are solely his own and have no connection to anyone in his family"Here is 3 minutes and 35 seconds of Karine Jean-Pierre refusing to answer any questions about Hunter Biden. "As it relates to anything related to Hunter Biden, I am just not going to respond to it from here."Garland: "Some have chosen to attack the integrity of the Justice Department by claiming that we do not treat cases alike. This constitutes an attack on an institution that is essential to American democracy... Nothing could be further from the truth."“Perspective on the Hunter Biden deal: I've reviewed data on 189,000 firearm possession cases by the DOJ. Not a single diversion. In fact, among all cases prosecuted by the DOJ less than 1% were resolved by a diversion.” - Brett L. Tolman, Executive Director of Right On Crime, Former US Attorney4Patriots https://4patriots.com Protect your family with Food kits, solar generators and more at 4Patriots. Use code TODD for 10% off your first purchase. Alan's Soaps https://alanssoaps.com/TODD Use coupon code ‘TODD' to save an additional 10% off the bundle price. BiOptimizers https://magbreakthrough.com/todd Use promo code TODD for 10% off your order. Bonefrog https://bonefrog.us Enter promo code TODD at checkout to receive 10% off your subscription. Bulwark Capital http://KnowYourRiskRadio.com Find out how Bulwark Capital Actively Manages risk. 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