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Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.10.376657v1?rss=1 Authors: Cottaar, M., Wu, W., Tendler, B. C., Nagy, Z., Milller, K., Jbabdi, S. Abstract: Purpose: Myelin has long been the target of neuroimaging research due to its importance in brain development, plasticity, and disease. However, most available techniques can only provide a voxel-averaged estimate of myelin content. In the human brain, white matter fibre pathways connecting different brain areas and carrying different functions often cross each other in the same voxel. A measure that can differentiate the degree of myelination of crossing fibres would provide a more specific marker of myelination. Theory & Methods: One MRI signal property sensitive to myelin is the phase accumulation, which to date has also been limited to voxel-averaged myelin estimates. We use this sensitivity by measuring the phase accumulation of the signal remaining after diffusion weighting, which we call DIffusion-Prepared Phase Imaging (DIPPI). Including diffusion weighting before estimating the phase accumulation has two distinct advantages for estimating the degree of myelination: (1) it increases the relative contribution of intra-axonal water, whose phase is related linearly to the amount of myelin surrounding the axon (in particular the log g-ratio) and (2) it gives directional information, which can be used to distinguish between crossing fibres. Results: Using simulations and phantom data we argue that other sources of phase accumulation (i.e., movement-induced phase shift during the diffusion gradients, eddy currents, and other sources of susceptibility) can be either corrected for or are sufficiently small to still allow the g-ratio to be reliably estimated. Conclusions: This new sequence is capable of providing a g-ratio estimate per fibre population crossing within a voxel. Copy rights belong to original authors. Visit the link for more info
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MDS presents the latest research and findings from the field of Movement Disorders. Abstracts of articles from the Society Journal, Movement Disorders, are taken from the November 2013 (Vol. 28, Issue 13) issue.
Engineering small worlds: micro and nano technologies - for iPod/iPhone
Cancer Research. Looking at materials under fluid. Force Distance Spectroscopy explained and demonstrated.
Engineering small worlds: micro and nano technologies - for iPod/iPhone
Transcript -- Cancer Research. Looking at materials under fluid. Force Distance Spectroscopy explained and demonstrated.
Engineering small worlds: micro and nano technologies - for iPad/Mac/PC
Cancer Research. Looking at materials under fluid. Force Distance Spectroscopy explained and demonstrated.
Engineering small worlds: micro and nano technologies - for iPad/Mac/PC
Transcript -- Cancer Research. Looking at materials under fluid. Force Distance Spectroscopy explained and demonstrated.