Podcasts about Molecule

Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with René, covering:   How a lucky break brought him to Sartorius over 20 years ago, and what has changed and stayed the same over that time His journey from scientist to senior leader, and the evolution of biologics he has witnessed along the way The pace of innovation in bioprocessing, and how he thinks about speed, efficiency and flexibility Why innovation continues regardless of market cycles, through both boom and correction periods His perspective on the current biotech market reset and why it represents a healthy correction Despite building a €3.5bn powerhouse, how Sartorius has maintained a relentless focus on customers   René Fáber, born in 1975, has been Head of Bioprocess Solutions Division and Member of the Executive Board of Sartorius AG since 2019. In the same year, he became a Member of the Board of Directors of Sartorius Stedim Biotech S.A.; in 2023 he was appointed as CEO of the company. René Fáber studied chemistry in Bratislava, Slovakia, and earned his Ph.D. in polymer chemistry from the Technical University of Munich in Germany. He joined Sartorius in 2002, where he initially worked as a scientist on membrane modification. As Vice President, he held various management positions in R&D, Marketing for Filtration and Fermentation Technologies, as well as in Key Account Management. In his most recent position, he was responsible for the Product Development unit of the Bioprocess Solutions Division.     Molecule to Market is also sponsored by Bora Pharmaceuticals, and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!  

Is a hidden molecule in your food and water silently fueling cancer, Alzheimer's, and Parkinson's? Could the supplements you trust every day be making it worse?Dr. Stephanie Seneff is a senior research scientist at MIT (published in PNAS, Frontiers, FASEB) with a career studying nutrition, biology, and toxicology. In this conversation, she explains why deuterium — a heavier form of hydrogen — may be the most underrated driver of chronic disease, why cancer might be the body's repair response to deuterium-damaged mitochondria, and why most supplements may backfire.We discuss:◾ Why deuterium may be the most important molecule you've never heard of◾ How glyphosate stops your body from clearing deuterium◾ The two supplements you should stop taking immediately◾ Why she says: "I don't believe in supplements"◾ Why chemo may be working backwards on cancer◾ How to make your gut produce low-deuterium water◾ The folic-acid-in-pregnancy and autism connection◾ Why she drinks deuterium-depleted water every dayThis is Dr. Seneff's second appearance on Live Longer World. Her first episode on glyphosate is linked below.Episode Show Notes: https://livelongerworld.com/p/sseneff2Find me on X: https://x.com/aasthajs My health stack: https://www.healthstacked.com/aasthajsTIMESTAMPS:0:00 Why deuterium might be the most important molecule you've never heard of5:09 The hidden reason processed food is wrecking your health7:25 How deuterium breaks your mitochondria11:02 Glyphosate stops your body from rationing deuterium (and the osteoporosis link)18:23 Health Stacked19:07 No one is connecting gut health to deuterium, until now22:45 The two nutrients that help your gut clear deuterium25:29 Methylation, melatonin, and protecting your mitochondria33:14 Why melatonin supplements don't actually work34:08 The two supplements you should stop taking immediately38:06 How to make your gut produce low-deuterium water41:12 How glyphosate suppresses your MTHFR gene43:21 Why folate supplementation is a problem45:06 "I don't believe in supplements", Stephanie's case against them46:02 Why she's suspicious of fish oil47:47 The folic-acid-in-pregnancy and autism connection52:37 How glyphosate is quietly causing bone problems56:22 Inflammation is really a deuterium problem1:01:25 Gerald Pollack's EZ water and how your cells expel deuterium1:04:59 Why breast milk is low in deuterium1:09:03 Cancer's real job: repairing your mitochondria (and why chemo may be a mistake)1:23:14 How deuterium-depleted water may help heal cancer1:26:57 Deuterium and Parkinson's: how plaque traps it1:30:37 How to fight Parkinson's1:33:55 Why Stephanie drinks deuterium-depleted water every day1:36:37 What glyphosate does to your sulfation system1:38:38 How grounding reduces deuterium1:39:42 Jack Kruse on glyphosate and melanin1:40:08 Are seed oils high in deuterium? 1:45:05 Does where you live (and sunlight) affect your deuterium?1:47:05 Practical tips to manage your deuterium loadDr. STEPHANIE SENEFF:Website: https://stephanieseneff.net/X: https://x.com/stephanieseneffAASTHA, LIVE LONGER WORLD:Join 2,000+ others for practical health protocols on circadian alignment, light, sleep, & non-toxic living: https://livelongerworld.com/X: https://x.com/aasthajs Instagram: https://www.instagram.com/aasthajs/My health stack: https://www.healthstacked.com/aasthajsIntroducing HEALTH STACKED: https://www.healthstacked.com/I built the health store I've always wanted. Health Stacked is a vetted marketplace of 500+ health & longevity products across 12 categories like sleep, fitness, non-toxic home, lighting & EMF, and more. Products are screened for plastic, PFAS, and 20+ toxins. Inclusion is 100% merit-based. And every product has been hand-picked by me.RELATED EPISODES:Glyphosate Toxicity & Deuterium's Role in Cancer, Celiac, Aging | Dr. Stephanie Seneff: https://open.spotify.com/episode/4HFmNT0fLCckXvrC1XRSFt?si=cSv7wuPPTm2wE5YSMY2L3w

Quotes from the episode: "Ducts matter. Nobody cares much about them until something goes wrong." "HVAC systems are designed assuming clean, bare sheet metal." "Even a small layer of dust can become a mountain range to an air molecule." "Think like an air molecule." In this episode, Bill speaks with Dan Stradford of Action Duct Cleaning about what really happens inside HVAC duct systems over time and why cleaning can matter more than many people realize. Dan shares how the duct cleaning industry evolved from its "wild west" early days into a more standardized field through NADCA, with better equipment, training, and certification practices. Dan explains that even a thin layer of dust can disrupt airflow, increase turbulence, raise static pressure, and reduce system efficiency. Drawing from NADCA energy studies, he describes how cleaning returns, supplies, fans, coils, and air handlers each contributed measurable performance improvements, including major reductions in fan and compressor energy use. The conversation also covers how HVAC professionals can evaluate duct-cleaning contractors, when homeowners or building owners should consider cleaning, and why ductwork deserves more attention as a hidden yet critical part of indoor air quality, comfort, and system performance.   Dan'sLinkedIn: https://www.linkedin.com/in/dan-stradford-b7509123/   The research paper we reference: https://www.sciencedirect.com/science/article/pii/S0378778824012635   Dan's company: https://actionduct.com/   The video Dan referenced: https://www.youtube.com/watch?v=HkGl7zljqN8   The National Air Duct Cleaners Association: https://nadca.com/       This episode was recorded in May 2026.

#thismorning | #Molecule to #Medicine: How Daraxonrasib is #Rewriting Pancreatic #Cancer #Drug #Development | Andrew R. Snyder, PhD., Monash University | #Tunein: broadcastretirementnetwork.com #Aging, #Finance, #Lifestyle, #Privacy, #Retirement, #wellness

Full Show Notes: https://bengreenfieldlife.com/timelinereplay In this special replay episode with repeat guest Dr. Anurag Singh from Timeline Nutrition, you'll explore the science of cellular health and longevity, including why mitochondrial function affects everything from energy and muscle performance to cognitive clarity and how well you age. Dr. Singh explains how urolithin A, a postbiotic compound derived from foods like pomegranates and berries, activates mitophagy, the body's cellular clean-up system that clears out worn-out mitochondria and replaces them with new ones, and how clinical research shows it can support muscle strength, endurance, immune resilience, and cognitive function. You'll also hear how diet, gut health, exercise, sleep, and recovery work alongside urolithin A to build a stronger, more resilient physiology over time. Dr. Anurag Singh is Chief Medical Officer at Timeline Nutrition, with an M.D. in internal medicine and a Ph.D. in immunology. He has authored more than 50 scientific articles, been awarded over 20 patents, and led more than 50 randomized clinical trials. His decade of research on urolithin A has produced multiple clinically validated products bringing longevity science directly to consumers. Episode Sponsors: BON CHARGE: A holistic wellness brand with products that address sleep, performance, recovery, hormone balance, and inflammation. Go to boncharge.com/GREENFIELD and use code GREENFIELD to save 15%. Troscriptions: A buccal troche delivery system that bypasses digestion to deliver pharmaceutical-grade compounds directly through your cheek mucosa for faster onset and higher bioavailability. Visit troscriptions.com/BEN or use code BEN for 10% off your first order. Timeline: High-performance products powered by Mitopure, delivering a precise dose of urolithin A for healthy aging. Mitopure starts at $79 at timeline.com/BEN. Just Thrive: The Gut Essentials Bundle pairs a probiotic clinically proven to arrive 100% alive in your gut with Digestive Bitters, a blend of 12 science-backed herbs. Visit justthrivehealth.com/BEN and save 20% with code BEN, or get a full refund if you don't notice a difference. Young Goose: To experience the transformative power of Young Goose's cutting-edge skincare products, visit younggoose.com and use code BGF10 at checkout to enjoy a 10% discount on your order. Manukora: You haven’t tasted or seen honey like this before, so indulge and try some honey with superpowers from Manukora. If you head to manukora.com/ben or use code BEN, you’ll automatically get $25 off your Starter Kit. See omnystudio.com/listener for privacy information.

NAD+ is one of the most critical molecules in your body — essential for energy production, DNA repair, brain function, metabolism, and healthy aging. And after menopause, your levels drop significantly. The result is fatigue that sleep doesn't fix, brain fog that won't lift, and a body that stopped responding the way it used to. But here is what most women — and most doctors — don't know: supplementing without testing is guesswork. In this episode, I sit down with Dr. Jin-Xiong She, founder of Jinfiniti Precision Medicine and one of the world's leading NAD+ researchers, to talk about why intracellular NAD+ testing is the only way to know where your levels actually are — and what to do about it. About Dr. Jin-Xiong She: Dr. Jin-Xiong She is the founder and CEO of Jinfiniti Precision Medicine and a Distinguished Research Professor at Augusta University. He has authored more than 400 peer-reviewed scientific publications, secured over $100 million in research funding, and holds multiple patents in precision medicine and metabolic health. His work on intracellular NAD+ testing has made him one of the most important voices in longevity and cellular health science today. In this episode: Why NAD+ declines so dramatically after menopause What low NAD+ actually feels like in your body The difference between intracellular testing and guessing NR versus NMN — what the science actually says How to dose correctly based on your results Why most women are supplementing wrong This is not another supplement conversation. This is precision medicine for midlife women. Medical Disclaimer: By listening to this podcast, you agree not to use this podcast as medical advice or to make any lifestyle changes to treat any medical condition in yourself or others. Consult your own physician for any medical issues that you may be having. This entire disclaimer also applies to any of my guests on my podcast. Learn more about Jinfiniti: Save 15% on all products and NAD test kits: https://www.jinfiniti.com/shop/?_ef_transaction_id=&oid=4&affid=128 Stay connected with JFW: Book your 60-minute Menopause Care Consultation: https://calendly.com/jillfooswellness/menopause-care-consult Follow on Instagram: @jillfooswellness Follow on Facebook: @jillfooswellness Follow on YouTube: @jillfooswellness Grab discounts on wellness products: https://www.jillfooswellness.com/health-products Enjoy 20% savings and free shipping at Fullscript for your favorite supplements by leading brands: https://us.fullscript.com/welcome/jillfooswellness/store-start Subscribe to the JFW newsletter at www.jillfooswellness.com and receive your FREE Guide on How To Create Your Menopause Health Equation Ebook. Schedule your complimentary consultation here: https://calendly.com/jillfooswellness/30-minute-zoom-consultations Join the Group Health Coaching cohort here: https://www.jillfooswellness.com/group-coaching If you're a Chicago-area midlife woman, check out the Chicago Menopause Collective, a nonprofit dedicated to navigating menopause locally with experts: https://chicagomenopausecollective.org

NAD+ has become the longevity industry's favorite molecule, sold as as a supplement and as a four-hour IV that promises sharper thinking, more energy, and slower aging. But a new 2026 paper complicates the very story it was built on. In this episode, Jeff breaks down what NAD+ actually is, what the human trials really show, and why the gap between a $40 oral supplement and a $1,200 IV drip matters more than the marketing admits. You'll learn about: What NAD+ does in the body and why it got tied to aging The new research questioning whether NAD+ truly declines with age Oral NR and NMN versus IV infusions, and what the evidence supports The risks rarely mentioned, including the cancer question Why the saline, B vitamins, and forced rest may explain how good people feel This episode is for anyone weighing NAD+, longevity supplements, or an IV drip, and who wants to tell real science from wellness hype first. This episode was made possible by: LMNT: Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinklmnt.com/commune. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at ⁠vivobarefoot.com/commune⁠. Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line. Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE”

Our trusted source for Methylene Blue: https://www.troscriptions.com/muscle (10% off) Functional medicine Dr. Scott Sherr joins Ben Pakulski to break down methylene blue — the 100-year-old compound that's become one of Ben's favorite tools for energy, focus, and endurance. Dr. Sherr explains how it reboots mitochondrial function in days (not months), how one endurance athlete he coaches cut three hours off a 100-mile race, and how to dose it safely. Plus the warning most people never hear: why the majority of methylene blue sold online is contaminated, and what to look for in a clean source. In this episode… → The bottleneck behind almost everything (energy, brain, recovery, fat loss)  → The four complexes of your electron transport chain, and where most men are blocked → Why statins might be quietly trashing the system you're trying to optimize → Which molecule does "ninja moves" for mitochondrial dysfunction → The exact dosing protocol Scott uses for performance, travel, sauna, and endurance About Dr. Sherr Dr. Scott Sherr is a board-certified Internal Medicine physician and one of the leading clinical voices on methylene blue and mitochondrial medicine. He is certified to practice Health Optimization Medicine (HOMe) — a root-cause framework he helped bring to the U.S. as founder of HOMe-SF, the country's first HOMe clinic — and is a specialist in Hyperbaric Oxygen Therapy (HBOT). He is the COO of Troscriptions (the precision-dosed troche company behind Just Blue, Tro+ Blue, and Blue Cannatine) and its parent, Smarter Not Harder, as well as COO of the nonprofit Health Optimization Medicine and Practice (HOMe/HOPe) USA, which trains doctors to detect and correct the root causes of health. He is also co-founder of OneBase Health, an integrative HBOT ecosystem. He has consulted for Upgrade Labs, Remedy Place, and other wellness ventures, and lives in Louisville, CO with his wife and four kids. Key credentials Board-Certified Internal Medicine Physician  Hyperbaric Oxygen Therapy (HBOT) specialist  COO, Troscriptions / Smarter Not Harder COO, Health Optimization Medicine & Practice (HOMe/HOPe) USA  Co-Founder, OneBase Health  Connect with Dr. Sherr Instagram: https://www.instagram.com/drscottsherr/ LinkedIn: https://www.linkedin.com/in/drsherr Website: https://drscottsherr.com/ Work with Muscle Intelligence The proven system 1000+ men use to stay lean, strong, clear, and capable. https://www.muscleintelligence.com/apply/ If you're interested in working with Ben. ben@muscleintelligence.com Join 200,000 men in their prime, reading our weekly newsletter: http://muscleintelligence.com/newsletter

Send us Fan MailFifteen minutes can be enough to shake your sense of self and that is exactly why people are paying attention to 5-MeO-DMT. I'm joined by Stephan Kirby, co-founder of the Mindscape Psychedelic Institute, to unpack what this psychedelic actually is, why many people call it Bufo, and why the ethical conversation matters just as much as the mystical one.We talk about the “god molecule” effect people report at a full-release dose: ego dissolution, a sudden drop-out of identity and story, and a return that can feel like waking up with fresh space around old habits. Stephan shares why the experience is often described as less visual than traditional DMT and more like pure consciousness, and how that can shift depression, anxiety, trauma patterns, and fear of death. We also explore why some people compare it to near-death experiences, and what it means to come back holding life a little more lightly.Safety is the thread running through everything. We get into trauma-informed psychedelic facilitation, proper screening, informed consent, medication considerations, and why a person should never be left unsupported when they are not aware of their surroundings. Stephan also explains why integration is the real work: bringing the insight into daily life through presence, breathwork, and practices that help the nervous system regulate, rather than chasing repeated peak experiences.If you're curious about psychedelic therapy, nervous system reset, somatic release, and the move from underground use towards research and clinical access, this conversation will give you a grounded place to start. Subscribe, share the podcast with someone who's curious, and leave a review with the question you want us to explore next.Music from #Uppbeat (free for Creators!):https://uppbeat.io/t/sky-toes/featherlightLicense code: ZTXJPK8BA5WMLKSF My new novel The Red Magus has recently been published in conjunction with the Unbound Press. An entralling mystical adventure set across time and space, where past and current lives converge. Find it on Amazon and Barnes & Noble. A call to action to help us keep spreading the spiritual ripple xxSupport the showBe a Compassion Crusader!Please like, share and subscribe!https://www.buzzsprout.com/1827829/supporters/newSubscribing to the podcast opens additional episodes with meditations, exercises, concepts and ideas from Freedom of the Soul.  Find your Soul purpose for only a few pounds a month. Click on the link below:-https://www.buzzsprout.com/1827829/subscribeNatasha Joy Pricewww.dandeliontherapies.co.ukFacebook - Dandelion TherapiesInstagram - natashajoyprice Books:-Freedom of the Soul - available on Amazon UK The Red Magus - available on Amazon and Barnes & Noble.

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with:   Kaan-Fabian Kekec, Partner Simon Kucher Kurt Nielson, President, Longview Leader Melanie Wamsler, External Network Strategy Lead, Takeda Rocco Paracchini, Vice President, Morpho   Your host, Raman Sehgal, discusses the state of contract manufacturing with his guests live from CDMO Live Europe 2026. The event was hosted by PharmaSource and Molecule to Market,   Molecule to Market is also sponsored by Bora Pharmaceuticals and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

This isn't a conversation about supplements. It's a conversation about energy, clarity, and coming back to life.If you're exhausted, foggy, depleted, or wondering if this is simply what midlife feels like now... this conversation matters.Because I was there too.When I first met Chris Burris, chief scientist and founder of My Vital C, I was still deep in the grief portal, hormonal repair, and a heaviness I didn't have language for yet.And then something began to change.Not overnight. Not magically. But because I was introduced to something that works at the level of the mitochondria, the energy systems inside the body that impact everything from mental clarity and nervous system regulation to sleep, inflammation, vitality, and resilience.Chris has been manufacturing the C60 molecule commercially since 1991, five years before the scientists who discovered it won the Nobel Prize. What began as a scientific pursuit eventually evolved into a wellness breakthrough now getting attention from some of the most trusted voices in biohacking and longevity.But what matters most to me is this: I felt the difference.And then I watched nine women on my retreat feel it too. Three days in, every single one of them noticed a shift. More clarity. More presence. More energy. Better sleep. Less fog. Feeling more like themselves.That's when I knew I needed to bring Chris onto Fire and Soul.In This EpisodeWhy so many women in midlife feel foggy, depleted, and exhaustedThe hidden role mitochondria play in energy, sleep, focus, and resilienceChris's BOSS Theory and how stressed mitochondria impact the whole bodyWhy you take it in the morning and often sleep better at nightThe retreat experience that made me pay attentionSkin changes, energy shifts, and the three-month arc many people experiencePets, longevity research, and the surprising breadth of testimonialsWhat it feels like to finally come back online after depletionAbout Chris BurresChris Burres is the chief scientist and founder of My Vital C and has been manufacturing the C60 molecule commercially since 1991. He's a published author, longevity researcher, and one of the longest-standing manufacturers of this molecule in the world. Find him at myvitalc.com.ResourcesGet My Vital C with Michelle's discount here.Chris's book Live Longer and Better is available on Amazon. Signed copies are available through the landing page, and 100% of the signature proceeds support Operation Underground Railroad.Work with meVisit michelle-sorro.com to explore everything available and find what's right for you right now.Let's connect Instagram: @michellesorro Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Nathan Bryan—world-renowned nitric oxide researcher with over 25 years of pioneering work, founder of N1O1, and author of The Secret of Nitric Oxide: Bringing Nitric Oxide to Life—joins us to reveal why this “miracle molecule” may be the most important factor in your health that you've never heard about. Trained under Nobel Laureate Dr. Ferid Murad and responsible for seminal discoveries on nitric oxide's role in the body, Dr. Bryan explains how declining nitric oxide levels drive fatigue, high blood pressure, chronic inflammation, poor circulation, brain fog, sexual dysfunction, and accelerated aging. He also shares the surprising truth about your oral microbiome, why everyday habits like using mouthwash or antacids destroy nitric oxide production, and the simple, science-backed strategies to naturally restore it. You'll walk away with practical tools to boost nitric oxide through diet, lifestyle, and targeted supplementation—so you can improve energy, cardiovascular health, cognitive function, and longevity starting today. Whether you're battling low energy, looking to prevent chronic disease, or optimizing performance at any age, this conversation delivers foundational insights that can transform how you feel and function. Connect with Dr. Nathan Bryan and explore his nitric oxide solutions at n1o1.com.Become a supporter of this podcast: https://www.spreaker.com/podcast/i-am-refocused-radio--2671113/support.Subscribe now at YouTube.com/@RefocusedNetworkThank you for your time. 

In this episode, Swami Revatikaanta sits down with Ananta Das (Franco Erazo) to explore the world of psychedelics and earth medicine in the spiritual world.Following a successful corporate career, Ananta Das immersed himself in the world of shamanic earth medicines—specifically Kambo and Bufo (5-MeO-DMT). In this mature conversation, Ananta Das shares his gratitude for these sacred tools, highlighting how they served as powerful catalysts to wake him up and point him toward the Divine.Together they explore how a deep respect for shamanic traditions led Ananta Dad to step beyond them—meeting Paramahamsa Vishwananda, taking Vaishnava devotee initiation, and finding a lifelong path to carry him upwards and onwards.Connect with the Community:

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with:   Fred Fleitz, SVP, CMC and Development Chemistry, Arrowhead Pharmaceuticals Jason Costigan, Head of CMC, Corsera Health Alison Moore, CEO and President, Codexis, Inc. Muthu Kandasamy, VP of Medicinal Chemistry, Wave Life Sciences    Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology ecosystem with his guests live from TIDES 2026. The event was hosted by Codexis and Molecule to Market,   Molecule to Market is also sponsored by Bora Pharmaceuticals and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

Your mood struggles might not be a mindset problem — they might be a methylation problem. In this episode, Nurse Doza breaks down the TMG supplement (trimethylglycine), how it drives serotonin and dopamine production, and why pairing it with SAMe in BLISS delivers clean energy and mood support — no caffeine, no stimulants, results in minutes. Featured Partner: MSW Nutrition — BLISS BLISS by MSW Nutrition combines two of the most underutilized mood-support compounds in functional medicine — trimethylglycine (TMG) and SAMe — in a fast-absorbing sublingual powder. Together, they fuel the methylation pathways your body needs to produce serotonin, dopamine, and sustainable energy — exactly the mechanisms Nurse Doza unpacks in this episode. No caffeine. No fillers. No stimulants. Just the two ingredients your brain chemistry has been waiting for.

Your relationships are reshaping your biology in ways that diet and exercise alone cannot fix, and the science behind it will change how you think about longevity, metabolism, and what it actually means to be healthy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Molly Maloof, a physician and one of the most innovative voices in personalized medicine, functional medicine, and human performance. Since 2012, she has advised or consulted for over 50 companies across digital health, consumer health, and biotechnology. She pioneered a course on healthspan at Stanford University and founded Adamo Bioscience, a company dedicated to unlocking the science of love as a pathway to healing and human connection. Dr. Maloof brings a rare combination of clinical depth, biohacking credibility, and entrepreneurial range to one of the most overlooked conversations in longevity. Together, Dave and Dr. Maloof dig into the neurobiology of love and attachment, the hormonal drivers of the sex drive and pair bonding, and how chronic isolation wrecks your metabolism at the cellular level. They explore the cell danger response and how toxic relationships, mold exposure, and trauma can lock your cells into a self-protection mode that blocks healing. They also cover psychedelics as hormetic tools, oxytocin as nature's medicine, the placebo response, peptide therapy for mitochondrial repair and anti-aging, and why regenerative medicine is about to rewrite the rules of human lifespan. If you are serious about biohacking your body from the inside out, this episode is essential. You'll Learn: Why human connection is a biological necessity, not a lifestyle preference, and what isolation does to your mitochondria and metabolism How the three neurobiological drives of sex, romantic love, and attachment are wired into your hormones and what happens when they go wrong What the cell danger response is, why it gets stuck, and which peptides, supplements, and therapies help break the cycle How oxytocin drives wound healing, immune function, and the placebo response Why psychedelics work as hormetic love drugs and how they reproduce the neurobiology of romantic love The top peptides for mitochondrial repair, brain optimization, and telomere biology Why Dave and Dr. Maloof believe we have already reached longevity escape velocity How AI is accelerating precision medicine, protein folding breakthroughs, and the future of anti-aging therapeutics Why fasting, breathwork, neurofeedback, and somatic therapies all converge on the same biological reset mechanism How to build the adaptive capacity and bioenergetic reserves to bounce back from anything Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out - Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18 - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Molly Maloof, Adamo Bioscience, Stanford University, personalized medicine, functional medicine, healthspan, longevity, biohacking, human performance, anti-aging, regenerative medicine, longevity escape velocity, cell danger response, mitochondria, mitochondrial health, oxytocin, vasopressin, dopamine, serotonin, neurobiology of love, attachment theory, pair bonding, sex drive, hormone replacement therapy, testosterone, estrogen, menopause, andropause, libido, female sexual dysfunction, relationship biology, social health, isolation, community, co-regulation, trauma healing, psychedelics, MDMA, psilocybin, ibogaine, ayahuasca, hormetic stress, social hormesis, neurofeedback, 40 Years of Zen, breathwork, nervous system regulation, HPA axis, cortisol, mast cell activation, histamine, long COVID, mold exposure, phospholipid therapy, glutathione, vitamin C, BPC-157, TB500, SS31, epothilone, SELANK, SEMAX, BDNF, telomere biology, telomerase, peptides, GLP-1, placebo response, wound healing, metabolism, continuous glucose monitoring, gut health, AI, precision medicine, supplements, brain optimization, neuroplasticity Resources: • Grab Molly's Book The Spark Factor: https://www.amazon.com/Spark-Factor-Supercharging-Optimizing-Feeling/dp/0063207206 • Learn More About Dr. Molly's Work: https://drmolly.co/ • Visit Your Healthspan Journey: https://yourhealthspanjourney.mystrikingly.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:28 – Intro 01:39 – COVID Isolation & Its Effects 03:11 – Science of Love & Hormones 04:24 – Psychedelics & Love Chemistry 09:22 – Cell Danger Response 11:07 – AI, Tech & Human Connection 13:20 – Social Connection as Medicine 20:50 – Placebo, Care & Psychedelics 24:49 – Altered States & Healing Modalities 30:09 – Peptides & Longevity Drugs 35:44 – Mast Cell & Personal Health Challenges 43:46 – Regenerative Medicine & The Future 46:17 – Longevity Escape Velocity 50:05 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today, I'm joined by the insightful Siobhan Mitchell PhD, a leading expert on women's health, mitochondria, and metabolic resilience. In our conversation, Siobhan reveals why so many women in their 30s and 40s feel like their metabolism is suddenly “broken,” and unpacks the real science behind what's happening beneath the surface—especially as our hormones begin to shift. Episode Timestamps: Introduction and host welcome ... 00:00:00 Introducing Speaker B and focus on women's health ... 00:04:30 Growing interest in women's health and clinical gaps ... 00:05:12 Body composition and metabolic changes in perimenopause ... 00:06:01 Hormonal shifts—not a broken metabolism ... 00:09:21 Addressing the root cause versus band-aids like GLP-1 ... 00:11:10 What's happening beneath the surface in early perimenopause ... 00:12:40 Role of estrogen in appetite, glucose, and fat storage ... 00:13:12 Visceral fat, inflammation, and accelerated aging ... 00:15:02 Estrogen's connection to mitochondrial function ... 00:16:15 Brain, muscle, and cognitive declines with estrogen loss ... 00:16:44 Environmental and mitochondrial factors in PCOS ... 00:21:09 Shift to belly fat and why fat storage changes ... 00:22:58 Mitochondria, immune system, and autoimmunity in women ... 00:29:16 Phytoestrogens, soy, and S-equol as hormone alternatives ... 00:32:37 S-equol's benefits: metabolic, bone, and brain health ... 00:35:50 Soy fears, GMOs, and the purity of S-equol ... 00:46:25 Microbiome, Bifidobacterium breve, and estrogen recycling ... 00:49:18 GLP-1s versus supporting the root cause ... 00:53:01 Optimizing estrogen signaling for health span and menopause timing ... 00:55:20 When to use S-equol: timing and benefits ... 00:55:54 Reversing visceral fat and lifestyle factors ... 01:03:28 Our Amazing Sponsors: Manukora Honey - A simple upgrade to your daily routine, this Manuka honey delivers antioxidants, prebiotics, and naturally occurring MGO that you won't get from regular sweeteners; head to http://manukora.com/natniddam to save up to 31% plus $25 in free gifts with the Starter Kit. Mitopure Gummies by Timeline - These clinically researched gummies support mitophagy to help renew your mitochondria and boost cellular energy, giving you a stronger biological foundation for resilience—visit http://timeline.com/nat20 to get 20% off. Daily Gut Detox by Just Thrive Health – A gentle, science-backed detox powered by clinically proven immunoglobulins that bind and remove toxins while supporting your gut, immune system, and digestion—without harsh flushing or discomfort. Visit JustThriveHealth.com/NAT20 and use code NAT20 for 20% off your order, risk-free. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

The Other Side of the Story with Tom Harris and Todd Royal – Not surprisingly, the past century's increase in this essential ingredient for plant photosynthesis is greening the planet, leading to greater crop yield, shrinking deserts, and increasing the density of forests. Rather than wasting trillions of dollars attempting to attain net-zero, we should focus on issues we know to be real, such as air, land, and...

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with Daniel Hurni, Supply Chain Enterprise Capability Lead at Roche.   Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with Dan, covering:   Why working all over the world was a key competent in building his confidence, and his understanding of people and perspectives from different cultures. The value of doing an MBA as a technician, and the need to master yourself and becoming the boss of yourself before leading others. A behind the scenes peek of CDMO sourcing and selection at small and a big pharma across different modalities.... and the importance of relationship building. Taking on a global supply chain lead at big pharma, and the job of navigating risk... and why you can only plan so much. How he's excited by, and thinking about AI with respect to supply chain, and why he will only apply it where it makes sense. Why listening, empathy, mentorship and networking are vital for survival and growth in a big pharma company. Top tips for large and specialist CDMOs.   With over 20 years of experience driving operational transformation in the life sciences sector, Daniel has established a reputation for optimizing end-to-end supply chains and navigating the complexities of the global pharma and biotech landscape. Throughout his career, he has successfully led high-stakes initiatives—ranging from aseptic Tech Transfers for sterile drug products to large-scale M&A integrations—consistently delivering cost reductions and scalable, patient-centric solutions within complex matrix environments. In small and large pharmaceutical companies.   Daniel specializes in bridging the gap between digital innovation and physical operations, leveraging AI, data integration, and advanced analytics to enhance S&OP and network design. Beyond his technical leadership in manufacturing and supplier management, he is a seasoned change management architect, adept at aligning functional priorities with enterprise strategy to drive operational agility. Daniel is also a frequent collaborator and thought leader who focuses on mentoring cross-functional teams and influencing stakeholders at all levels to build the intelligent, resilient supply chains of the future.     Molecule to Market is also sponsored by Bora Pharmaceuticals and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

"The more you're attached to your identity, the further you are away from joy." Joy is not something earned through money, status, or achievement. It's something already within us that gets buried under identity, expectations, and the constant need for validation. Real fulfillment comes from reconnecting with who we truly are beneath our thoughts, labels, and conditioning. The episode explores how attachment to identity creates suffering, while presence, gratitude, meaningful relationships, and self-awareness bring people back to a more joyful and connected way of living.  Larry Kesslin shares how years of entrepreneurial success still left him searching for something deeper. Experiences in Africa and Mexico challenged his assumptions about happiness, poverty, and purpose, ultimately reshaping the direction of his life and work. Larry explains how joy becomes easier when expectations are released, relationships deepen, and people begin living from awareness instead of reaction.  Larry is a speaker, author, and conscious leadership coach focused on helping high achievers reconnect with meaning, purpose, and joy. After stepping away from a successful entrepreneurial career, he dedicated his work to building conscious community, guiding purpose-driven leaders, and creating spaces where people can connect through authenticity, service, and self-awareness.  Learn more & connect: Email: larry@Kesslin.com Website: https://5-dots.com Raymond Aaron has shared his vision and wisdom on radio and television programs for over 40 years. He is the author of over 100 books, including Branding Small Business For Dummies, Double Your Income Doing What You Love, Canadian best-seller Chicken Soup for the Canadian Soul, and he co-authored the New York Times best-seller Chicken Soup for the Parent's Soul. Raymond's latest, co-authored book is The AI Millionaire's Path: Discover How ChatGPT‐Written Books Become Bestsellers and How They Can Make You a Millionaire Author!. www.Aaron.com

Dr. Nathan S. Bryan is a PhD biochemist, nitric oxide pioneer, and professor of molecular medicine at the University of Texas Health Science Center in Houston. He has spent over 25 years researching nitric oxide, holds more than a dozen patents, has published hundreds of highly cited papers, and authored six books including The Secret of Nitric Oxide: Bring the Science to Life. He is the founder of N101 (formerly Pneuma Nitric Oxide) and Bryan Therapeutics, where he is developing nitric oxide-based therapies for Alzheimer's, heart disease, and non-healing wounds. At 52 years old, Dr. Bryan has the vascular age and biological organ age of a 29-year-old — and he attributes it entirely to nitric oxide.This episode is a masterclass on one of the most important molecules in the human body that almost nobody is talking about. If you care about longevity, brain health, blood pressure, energy, inflammation, or disease prevention — this one is essential listening.In this episode, we cover:- What nitric oxide actually is a signaling molecule that regulates blood flow, activates mitochondria, releases stem cells, and prevents telomere shortening- Why the loss of nitric oxide production is now recognized as the earliest event in the onset of every age-related chronic disease- The five symptoms of nitric oxide deficiency — in order: erectile dysfunction, high blood pressure, metabolic disease, exercise intolerance, and brain fog leading to Alzheimer's- Why Alzheimer's is actually diabetes type 3 — insulin resistance in the brain — and why every Alzheimer's drug has failed because they're targeting the wrong thing- The link between erectile dysfunction and Alzheimer's — and why one is a direct predictor of the other- Why cancer can't grow in tissue with adequate nitric oxide, blood supply, and pH- What kills your nitric oxide production: sugar, fluoride toothpaste, antacids, proton pump inhibitors, antibiotics, antiseptics, mouth breathing, sedentary lifestyle, and lack of sunlight- Why beet products are one of the biggest marketing frauds in the supplement industry — and what they actually do (hint: kidney stones)- The four things to stop doing immediately to restore natural nitric oxide production- The big three lifestyle activators: moderate exercise, 20–30 minutes of daily sunlight, and nasal breathing10% off Dr. Bryan's products for listeners: n101.com — Discount Code: AMY10Connect with Dr. BryanWebsite: n101.comYouTube: @DrNathanSBryanNitricOxide Instagram: www.instagram.com/drnathansbryan/LinkedIn: www.linkedin.com/in/drnathansbryan/X: @drnitric Book: The Secret of Nitric Oxide Please remember to rate, review, and follow the show – and share with a friend!Subscribe to the newsletter:https://mailchi.mp/amyedwards/sign-up-to-amys-newsletterCheck out our new Comedy Wellness Podcast: Anything But Mid, cohosted with Whitney Stropp:https://podcasts.apple.com/us/podcast/anything-but-mid/id1849386215https://www.youtube.com/@AnythingButMidFind Amy's affiliates and discount codes: https://amyedwards.info/affiliatepageAll links: ⁠⁠⁠amyedwards.info⁠⁠⁠Instagram: ⁠⁠⁠@realamyedwards⁠⁠⁠Fight For Her: ⁠⁠⁠fightforher.net⁠⁠⁠TikTok:⁠⁠⁠ @themagicbabe⁠⁠⁠YouTube: ⁠⁠⁠YouTube Channel⁠⁠⁠Podcast: ⁠⁠⁠The Amy Edwards Show Podcast⁠⁠⁠Free Course:⁠⁠⁠ The Ageless Mindset⁠⁠⁠Full Course: ⁠⁠⁠The Youthfulness Hack⁠⁠⁠Amy's hair by ⁠https://www.thecollectiveatx.com⁠Podcast editing by https://podcastmagician.com/Get my FREE course "The Ageless Mindset: The Ultimate Guide to Look Younger and Feel Happier!" HERE: ⁠https://best-you-life.teachable.com/p/the-ageless-mindset-the-ultimate-guide-to-look-younger-feel-happier⁠Get the full course “The Youthfulness Hack: The Secret System to Reverse Aging Fast and Create a New, Radiant You!” Out now! ⁠https://best-you-life.teachable.com/p/the-youthfulness-hack⁠

In 1985, three scientists at Rice University discovered a carbon molecule so structurally perfect it eventually earned them the Nobel Prize in Chemistry. What nobody anticipated was what would happen when researchers gave it to rats — a 90% extension in lifespan, the longest longevity result ever recorded in mammalian history.Chris Burres has been manufacturing this molecule since 1991, five years before the Nobel Prize was awarded. He joins Dr. Brandon Crawford to break down how ESS60 (Carbon 60) works at the mitochondrial level, why it functions as a buffering oxidative stress system rather than a conventional antioxidant, and what the growing clinical evidence suggests about its effects on sleep, inflammation, cognition, and long-term healthspan.ResourcesMyVitalC Exclusive Offers: 40% discount on 6-bottle bundle, $30 coupon, and 18 free biohacking tips when you use the link myvitalc.com/crawfordLive Longer and Better by Chris Burres and Jerome Corsi (autographed copies available with proceeds supporting Operation Underground Railroad)Operation Underground Railroad — Non-profit combating child exploitation (100% of autograph fees donated)Live Beyond the Norms Podcast hosted by Chris BurresFollow MyVitalC on Instagram2012 Baati Study — Peer-reviewed research showing 90% lifespan extension in Wistar rats SES Research Inc. — Manufacturing and research company (since 1991, Houston, Texas)‍Products528 Innovations LasersNeuroSolution Full Spectrum CBDNeuroSolution Broad Spectrum CBDNeuroSolution StimpodSTEMREGEN®Learn MoreFor more information, resources, and podcast episodes, visit https://tinyurl.com/3ppwdfpm

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with: Jennifer Chadwick, Founder and Principal at Jennifer Chadwick Consulting Firelli Alonso, Founder / Principal Consultant at ConsultFi Biologics LLC Umar Hayat, Founder, CEO at Accanito Inc   Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology ecosystem with his guests live from Bora Nexus 2026. The event was hosted by Bora Pharmaceuticals and Molecule to Market,   Molecule to Market is also sponsored by Bora Pharmaceuticals and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

Text us a comment or question!What if the key to living longer wasn't just about diet and exercise - but something happening deep inside your cells?In this episode of The Over 50 Health & Wellness Show, I sit down with scientist and entrepreneur Chris Burres to explore one of the most fascinating - and controversial - topics in modern longevity science.We're talking about a Nobel Prize-winning molecule, mitochondrial health, oxidative stress, and what might be possible when it comes to extending both lifespan and healthspan.Now, before you roll your eyes and think, “Here we go… another miracle supplement…” - stick with me.Because this conversation is grounded in real science… and it might just change how you think about aging.Here's What You'll LearnWhy we age (what's actually happening inside your body)The role of oxidative stress and inflammation in agingWhat your mitochondria have to do with energy, fatigue, and longevityThe wild story behind a molecule that extended lifespan in animal studies by 90%What “longevity escape velocity” means—and why it matters for YOUHow improving sleep could be the most underrated longevity hackThe difference between lifespan vs. healthspan (and why you should care)Whether living to 100+ is realistic… or science fictionPractical ways to start improving your cellular health today The Big TakeawayAging isn't just about getting older - it's about what's happening at the cellular level.And if we can reduce the damage happening inside our cells - especially in the mitochondria - we may be able to dramatically improve how we feel, function, and perform… well into our later decades.This isn't about living longer just for the sake of it. It's about living stronger, sharper, and more energized for as long as possible. My Favorite MomentChris breaks down the concept of “longevity escape velocity” - the idea that medical advancements may soon extend life faster than we age.Translation?If you can stay healthy long enough… you may benefit from breakthroughs that completely change the game. Listen NowIf you're over 50 and want more energy, less inflammation, and a body that actually keeps up with your life… hit play and let's dive in! Connect with Chris BurresLearn more: https://www.myvitalc.com/silveredgeInstagram: https://www.instagram.com/myvitalcYouTube: https://www.youtube.com/myvitalcPodcast: Live Beyond the NormsBook: Live Longer and Better If you enjoyed this episode, do me a favor:Leave a 5 star review ⭐Share it with a friend who “feels older than they should”Tag me on Instagram @thesilver_edge Ready for a Real Plan?If you're tired of guessing—and you want a clear, proven path to getting leaner, stronger, and more energized after 50…Book your free Silver Edge Clarity Call here: https://go.silveredgefitness.com/clarirty-callLet's build a body Over 50 and frustrated with your progress? Click HERE to book a free Silver Edge Clarity Call and get a clear plan forward. Over 50 and frustrated with your progress? Book a free Silver Edge Clarity Call and get a clear plan forward.

Originally studied for its chemical properties, ESS60 gained unexpected attention when a toxicity study revealed that rats given ESS60 lived up to 90% longer than the control group.. Chris explains how this molecule may work at the root cause level—inside the mitochondria, the energy-producing centers of our cells. According to emerging research and the "buffering oxidative stress system" (BOSS theory), ESS60 may help neutralize reactive oxygen species, reducing oxidative stress and supporting cellular resilience.   TOPICS DISCUSSED: ESS60 Discovery & Nobel Prize Background Mitochondrial Function & Oxidative Stress Rat Longevity Study (90% Lifespan Increase) Inflammation & Aging (Inflammaging) Biohacker Adoption & Early Use Cases Product Development & Supplement Industry Challenges Real-World Testimonials & Athlete Performance Practical Usage, Dosing & Delivery Methods   More from Chris Burres: Website: myvitalc.com Instagram: @myvitalc TikTok: MyVitalC Facebook: My Vital C X: @MyVitalC Get Chris's Book: Live Longer and Better Listen to Chris's Podcast: Live Beyond the Norms Special Offer for all listeners: myvitalc.com/reversable   Leave us a Review: https://www.reversablepod.com/review   Need help with your gut? Visit my website gutsolution.ca to join a program: Get help now   Contact us: reversablepod.com/tips    FIND ME ON SOCIAL MEDIA: Instagram  Facebook  YouTube   

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with Steve Favaloro, Chairman and CEO of Genezen. Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with Steve, covering: His deep passion for operations, and how early lessons in hard work and customer service shaped his leadership Learning from Mark Bamforth and the entrepreneurial journey at Brammer Bio, culminating in a $1.7bn exit to Thermo Fisher Why gaining exposure to every seat at the table was critical in preparing him for the CEO role Building Genezen with a focus on strong values, hiring the right people and investing in differentiated capabilities How the cell and gene therapy market has evolved over the past decade, and why he remains optimistic about the future of curative medicines Why things inevitably go sideways in innovative drug development, and the importance of being prepared to navigate it Steve Favaloro is an experienced biotech executive, board member, and investor. He is currently Chairman and CEO of Genezen, a best-in-class gene and cell therapy CDMO with specialized expertise in viral vector manufacturing. Steve joined Genezen in 2023 and has built up a team of almost 300 employees, supporting gene and cell therapy innovators from early-stage, growth-oriented biotechs to established industry leaders. He is an executive advisor at Ampersand Capital Partners, a leading healthcare investor, and serves on the board of Biologos. He also serves on the board of advisors of Life Science Cares Boston. Prior to Genezen, Steve was CFO at Arbor Biotech, a next-generation gene editing therapeutic company. Steve also served as CFO at Arranta Bio, a leading CDMO for mRNA, from its founding in 2019 to its successful exit to Recipharm in February 2022.  Prior to this, Steve was a finance leader and ultimately CFO at Brammer Bio, where he oversaw a period of rapid expansion and capital deployment from 2016 to 2019 – leading up to its successful sale to Thermo Fisher Scientific in May 2019 for $1.7B. Before joining Brammer, Steve held finance roles of increasing responsibility at MilliporeSigma, Merck KGaA, and Bruker Corporation. Steve received his MBA and Master of Science from the Carroll School of Management at Boston College. Steve also received his Bachelor of Arts degree in Economics from Boston College.   Molecule to Market is also sponsored by Bora Pharmaceuticals and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

I've launched my book! Science Nonfiction: Behind the Scenes in University Research. Available in print and eBook (release date 6/1/26) and audiobook (available immediately) from all major distributors. Here it is on Amazon and Spotify (free with paid Spotify).

Dr. Joseph Kim solved cryo-EM structures of mu and kappa opioid receptors bound to the same small molecule — and found it does something different at each one.In this conversation, Dr. Kim walks through his transition from cryo-electron tomography to GPCR structural biology in Ashish Manglik's lab at UCSF, the strategy behind solving inactive-state receptor structures, and why his favorite GPCR — the galanin receptor — has resisted every small-molecule screen thrown at it.Key takeaways:How one molecule acts as an antagonist at mu and an inverse agonist at kappaWhy the galanin receptor's peptide binding mode blocks conventional drug discoveryWhat it takes to switch fields with no prior biochemistry trainingHow building tools on "vanilla" GPCRs prepares you for exotic targets

Send us Fan MailThis week, we shine our spotlight on the 2026 Naismith Awards Women's Defensive Player of the Year Presented by MOLECULE—Notre Dame great Hannah Hidalgo! A Trophy Life is presented by Jersey Mike's. WANT TO SUPPORT A TROPHY LIFE?Leave a rating and review on iTunes, Spotify, or wherever you get your podcasts. Your feedback only helps make the show better, and we appreciate your support! For more information about the Naismith Trophy Award, visit our home on the web.

Send us Fan MailDaniel Z. Lieberman, psychiatrist and co-author of The Molecule of More, joins Joe to explore the powerful role dopamine plays in shaping our desires, decisions, and sense of fulfillment.Joe and Dan discuss how dopamine isn't just about pleasure—it's about possibility. It drives us to chase the future, often leading us to idealize what's ahead while overlooking what's right in front of us. From career ambition to relationships, this constant pursuit can leave us restless, unsatisfied, and always searching for the next thing.Throughout the conversation, they examine the tension between “wanting” and “liking,” why achieving our goals can sometimes feel empty, and how modern environments—from social media to consumer culture—are designed to keep us in a dopaminergic loop.They also explore practical ways to create balance—how to strengthen “here and now” awareness through journaling, reflection, and intentional habits, and why slowing down is not natural, but something we must train ourselves to do.Joe and Dan also discuss: Why dopamine is better understood as a “prediction” or “possibility” molecule—not a pleasure one  The difference between wanting something and actually liking it  How the “Daisy effect” (idealizing the future) shapes our expectations and disappointments. How dating apps and social media amplify dopamine and distort reality  The transition from passionate love to companionate love—and why it matters  How a lifetime of goal-chasing (like in the military) conditions us to struggle with stillness  Why journaling helps uncover patterns, motivations, and meaning  Practical tools like meditation and breathwork to strengthen “here and now” awareness  The importance of asking “why” before chasing the next goal Whether you're navigating a transition, chasing a goal, or trying to better understand your own patterns, this episode offers a powerful framework for recognizing when you're being driven by the future—and how to reconnect with the present.Watch the interview on YouTubeA Special Thanks to Our Sponsors! Veteran-founded Adyton. Step into the next generation of equipment management with Log-E by Adyton. Whether you are doing monthly inventories or preparing for deployment, Log-E is your pocket property book, giving real-time visibility into equipment status and mission readiness. Learn more about how Log-E can revolutionize your property tracking process here!Meet ROGER Bank—a modern, digital bank built for military members, by military members. With early payday, no fees, high-yield accounts, and real support, it's banking that gets you. Funds are FDIC insured through Citizens Bank of Edmond, so you can bank with confidence and peace of mind. 

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with Felipe Furiati, Senior Director, External Supply Operations at Grünenthal.   Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with Felipe, covering:   Why he stepped away from big pharma to pursue an MBA in the US and transition into top tier management consulting, broadening his global perspective The pace and intensity of his time at Bain, and how it expanded his problem solving toolkit across industries The challenges, risks and opportunities involved in acquiring products and integrating supply chains How he approaches identifying, selecting and managing CDMO partners, and why product characteristics play a critical role Building and maintaining a CMO and CDMO network, and the key criteria he uses to assess and source new projects What strong vendor relationships really look like, why not every CDMO can be a strategic partner, and where CMOs can improve   Felipe currently works in External Supply Operations at Grünenthal, a mid-sized pharma organization with a vision of a world free of pain. He is an experienced professional in pharma strategy and operations, with a focus on external supply chain management across both pre launch and commercial products.   Originally from Brazil, Felipe has lived in Ireland and the United States, and is now based in Italy. His experience in the pharmaceutical industry is complemented by time in management consulting, where he gained exposure to a range of sectors including CPG and healthcare services.   Outside of work, Felipe is a mid of the pack endurance triathlete and enjoys spending time outdoors.     Molecule to Market is also sponsored by Bora Pharmaceuticals, and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

Marty Burke, a professor of chemistry at the University of Illinois and co-founder of Excelsior Sciences, on making small molecule synthesis more automated for AI.

Stronger, sharper years are possible when you target the source of aging.In this episode, Dr. Stephen Petteruti sits down with Chris Burris, Chief Scientist of MyVitalC, to focus on Carbon 60 (C60) and why it's gaining attention in longevity science. This Nobel Prize–recognized molecule acts as a potent antioxidant at the mitochondrial level, helping manage the oxidative stress that drives aging and many chronic conditions. Chris outlines how C60 is produced and why its unique structure allows it to neutralize large numbers of free radicals. The discussion ties this to real outcomes while stressing quality control, proper sourcing, and avoiding hype in the supplement space.  Dr. Stephen adds in the clinical context that aging accelerates when oxidative stress and inflammation outpace the body's defenses. Interventions like C60 may support resilience, but fundamentals remain non-negotiable.If longevity and performance matter, spend a few minutes with this episode. Tune in now: The Anti-Aging Breakthrough: Can This Molecule Help You Live Longer? (C60 Explained).Enjoy the podcast? Subscribe and leave a 5-star review on your favorite platforms.Chris Burres is the Chief Scientist at MyVitalC, known for his work on the groundbreaking molecule ESS60. His research is tied to one of the most significant longevity discoveries in history, demonstrating a remarkable 90% lifespan extension in Wistar rats. As the host of the Live Beyond the Norms podcast and Longevity Summit, Chris shares science-backed insights to help people live longer, healthier lives. He is also the author of Live Longer and Better, where he breaks down practical strategies for optimizing health and extending lifespan. Driven by a mission to make longevity science accessible, Chris continues to educate and inspire individuals to take control of their health and aging.LI: https://www.linkedin.com/in/chrisburres/IG: https://www.instagram.com/chrisburres/  MyVitalCWebsite: https://www.myvitalc.com/ IG: https://www.instagram.com/myvitalc/ LI: https://www.linkedin.com/company/myvitalc/X: https://x.com/myvitalc YT: https://www.youtube.com/myvitalc Pinterest: https://www.youtube.com/myvitalc TikTok: https://www.tiktok.com/@myvitalc  Dr. Stephen Petteruti is a board-certified physician specializing in longevity-focused, integrative medicine. He works with men navigating prostate cancer, testosterone and hormone health, aging, and performance using proactive, evidence-informed strategies grounded in real clinical practice. His approach prioritizes preserving function, strength, and quality of life while helping patients make clear, informed decisions beyond reactive, fear-driven care.Learn more: https://www.drstephenpetteruti.com/ Learn more: https://www.intellectualmedicine.com/ Connect with Dr. Petteruti on:⁠Instagram: ⁠https://www.instagram.com/dr.stephenpetteruti/⁠ Facebook: ⁠https://www.facebook.com/dr.stephenpetteruti⁠ Subscribe to Intellectual Medicine on:Apple Podcast: https://tinyurl.com/DrPetterutiApplePodcast Spotify: https://tinyurl.com/DrPetterutiSpotifyPodcast Disclaimer:The content presented in this video reflects the opinions and clinical experience of Dr. Stephen Petteruti and is intended for informational and educational purposes only. It is not medical advice and should not be used as a substitute for professional diagnosis, treatment, or guidance from your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your health regimen or treatment plan.Produced by https://www.BroadcastYourAuthority.com

In this episode of the Optimal Body Podcast, Doc Jen and Doctor Dom, both Doctors of Physical Therapy welcome Doctor Nathan Bryan, an expert in nitric oxide biochemistry. Doctor Bryan explains how nitric oxide, a short-lived signaling molecule, is essential for cardiovascular health, brain function, immune defense, and longevity. He discusses how modern lifestyle habits, including poor diet, sedentary behavior, fluoride toothpaste, and antiseptic mouthwash, deplete nitric oxide production. Doctor Bryan also shares practical health tips to restore levels, including exercise, nasal breathing, dietary changes, and his scientifically developed nitric oxide-based supplements, highlighting their potential to combat chronic diseases like Alzheimer's, diabetes, and heart disease. Needed Discount: Jen trusted Needed Supplements for fertility, pregnancy, and beyond! Support men and women's health with vitamins, Omega-3, and more. Used by 6,000+ pros. Use code OPTIMAL for 20% off at checkout! N1O1 Product Discount: Interested in grabbing some of the Nitric Oxide Products that Dr Nathan talks about? Check them all out here and use code OPTIMAL10 at checkout for a discount! Dr Bryan's Resources: N1O1 Website Dr Bryan on IG Dr Bryan on YT "The Secret of Nitric Oxide" We Think You'll Love Free Week of Jen Health Jen's Instagram Dom's Instagram YouTube Channel For full show notes and resources, visit https://jen.health/podcast/457 What You'll Learn: 01:26 Dr. Bryan explains why nitric oxide is a critical molecule for health, longevity, and disease prevention. 05:30 Dr. Bryan details how lifestyle factors and certain drugs disrupt nitric oxide production and enzyme function. 07:44 Explains the role of oral bacteria in nitric oxide production and the negative effects of fluoride and mouthwash. 10:18 How nitric oxide levels... Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Did you know that there is one molecule in your body that controls your blood pressure, brain function, sexual performance, sleep quality, immune response, and how fast you age? There is. It's known as nitric oxide.  After 40, most men are producing half the nitric oxide (NO) their body needs and almost none of them know it's happening. So we brought in Dr. Nathan Bryan, who has spent 25 years researching this one single molecule. He's published over 100 peer-reviewed papers, holds dozens of patents, and built a billion-dollar portfolio of companies around this science.Our conversation with Dr. Bryan exposes what your morning routine is actually doing to your body, debunks the beet supplement and L-arginine myths, explains why erectile dysfunction is a cardiovascular warning sign, not an isolated issue, and gives you four specific changes to make starting today.IN THIS EPISODE, YOU'LL LEARN:What nitric oxide (NO) is—and why losing it leads to fatigue, brain fog, and performance declineThe 4 everyday products killing your NO: fluoride, mouthwash, antacids, and sugarWhy mouthwash can cancel the benefits of your workoutHow ED can be an early warning sign of cardiovascular issuesWhy beet supplements and L-arginine may be ineffective—or worseHow nasal breathing and humming naturally boost nitric oxideTOP 3 SIMILAR EPISODES FROM MTM:Ep. 103 — How to Sleep Better with Navy SEAL Sleep Scientist Rob SweetmanEp. 130 — This Is How Stress Becomes Heart Disease with Dr. Fernando LamounierEp. 133 — Brain Injury Recovery Strategies: Dr. Mark Gordon on Hormone HealthFOLLOW DR. NATHAN BRYAN:@drnathansbryan on InstagramYouTube: Dr. Nathan S. Bryan — Nitric OxideBook: The Secret of Nitric Oxide — Amazon & Barnes & NobleN1O1 | Nitric Oxide Supplements by Dr. Nathan BryanNEW COURSE: Be the first to hear about our Awareness to Action (A2A) course launching May 27. Learn more here:https://focusnowtraining.com/a2a-course-interestFOLLOW MTM:Subscribe to our newsletter Text MTM to 33777: newsletter.focusnowtraining.comTraining & Corporate Workshops: focusnowtraining.comEpisodes & Resources: mentalkingmindfulness.comHosted on Ausha. See ausha.co/privacy-policy for more information.

PEA for Pain Relief: at least a 50% reduction in pain scores, no matter what pain condition the patient was experiencing!! And don't miss the following topics that Terry will also discuss on this show: Getting Rid of Warts with DIM, Keto Diet + Exercise = No Diabetes, I Slept All Night, Why am I Still Tired, What Does it Take to Enjoy Exercising?

Welcome to the latest episode of LIFTS, your bite-sized dose of the Latest Industry Fitness Trends and Stories. In this episode, hosts Matthew Januszek and Mohammed Iqbal explore one of the most talked-about topics in modern wellness: NAD and the rapid rise of longevity therapies. Joined by Rachele Pojednic, Chief Science Officer at Restore Hyper Wellness, the conversation breaks down what NAD actually is, how it functions within the body, and why it has become such a focal point in energy, recovery, and healthy aging. As wellness clinics, IV therapies, and performance treatments continue to grow in popularity, NAD has emerged as a central molecule in the conversation around optimisation and longevity. However, as interest increases, so too does the gap between consumer awareness, scientific understanding, and real-world application. The discussion explores the biology behind NAD, including its role in cellular energy production, metabolism, and DNA repair, while also examining the different forms of NAD and its precursors, such as NR and NMN. Matthew and Mo share their own experiences with NAD therapies, opening up a broader discussion around delivery methods, perceived benefits, and the difference between anecdotal outcomes and evidence-based practice. As the conversation develops, Rachel highlights the importance of understanding not just the therapy, but the underlying molecule, and why factors such as dosage, delivery method, and cellular transport play a critical role in determining effectiveness. The episode also addresses the wider challenges within the wellness industry, including the speed at which new therapies are being adopted, the influence of biohacking culture, and the growing need for scientific validation and safety data. For operators, this episode provides valuable insight into both the opportunities and responsibilities associated with integrating longevity and wellness services into fitness environments. In this episode, we cover: What NAD is and how it works in the body Why NAD levels decline with age The rise of NAD and wellness clinics The difference between NAD, NR, and NMN Why delivery method and molecule selection matter The gap between wellness hype and scientific evidence Safety considerations, dosage challenges, and unknowns

This week, it's back to the podium in Indianapolis to meet our 2026 Naismith Awards Men's Defensive Player of the Year Presented by MOLECULE: Florida's Rueben Chinyelu!Our weekly podcast is presented by Jersey Mike's.WANT TO SUPPORT A TROPHY LIFE?Leave a rating and review on iTunes, Spotify, or wherever you get your podcasts. Your feedback only helps make the show better, and we appreciate your support! For more information about the Naismith Trophy Award, visit our home on the web.

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with Tim Dietlin, Chief Executive Officer of ELIQUENT Life Science.   Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with Tom, covering:   Practical advice on the mindset required when navigating M&A from both sides Why he made the move from management consulting into executive search, and why it proved to be the right call How the hunter became the hunted when private equity firm GHO Capital came knocking to take him to ELIQUENT The challenge of integrating five successful businesses into one unified platform and brand Timeless lessons on working with private equity, while balancing senior leadership with family life Operating at the forefront of global regulatory change and the evolution of modern drug development   As Chief Executive Officer of ELIQUENT Life Sciences, Tim Dietlin steers the company's global priorities and strategic growth. His leadership guides ELIQUENT's team of unmatched regulatory experts and clears the path to better health.   Tim leads ELIQUENT's global business with a focus on bringing clarity to regulatory complexity. His strategic direction leverages ELIQUENT's combined capabilities and collective expertise to provide integrated solutions that bridge the spectrum of global regulatory challenges. Under his leadership, ELIQUENT's platform of comprehensive solutions deliver a full-service engagement that global life sciences innovators need to gain and maintain market authorization for their products.   With more than 25 years of leadership experience, Tim empowers the ELIQUENT team to redefine regulatory excellence and provide continued value to clients. Prior to joining ELIQUENT, Tim served in leadership roles with premier firms advising and serving the life sciences industry, including Campbell Alliance, IBM and Heidrick & Struggles.      Tim holds a BA from Loyola University Chicago, an MBA from DePaul University, and sits on the board of the Chicago chapter of the Juvenile Diabetes Research Foundation (JDRF).   Molecule to Market is also sponsored by Bora Pharmaceuticals and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

The global oil market still runs on a horribly fragmented system where physical barrels, paper contracts, and financial settlement operate in parallel but disconnected layers. Transactions are dependent on manual processes, emails, PDFs, and handshake relationships built over decades. For a trillion dollar industry, the core trading infrastructure remains slow, opaque, and largely inaccessible for all but the largest players.  This creates real operational and financial constraints. Settlement delays can stretch to 90 days, tying up working capital and exposing companies to liquidity risk. Market access is hobbled by lengthy know-your-customer  processes and high barriers to entry. Here in the spring of 2026, with the Strait of Hormuz blocked, these inefficiencies add up to systemic challenges that will make eventual recovery much harder than it needs to be.   It's time for a new approach, one that digitizes the physical barrel itself. By tokenizing crude oil into smaller, tradable units, markets can accelerate settlement, improve transparency, and broaden participation. Imagine a token that represents a real, physical quantity of oil, enabling traceability across the supply chain and creating a new layer of market visibility. This also opens the door to fractional ownership and new forms of capital access that were previously unavailable.  In this episode, I am speaking with Baron Lamarre, co-founder of INDEX, the International Digital Exchange, about how tokenization could fundamentally reshape oil trading. We explore the inefficiencies of today's system, the mechanics of turning barrels into digital assets, and why this shift could materially improve cash flow, transparency, and market access across the energy sector.

Today, I'm excited to welcome Michael Long to the podcast. Michael is a physicist-turned-writer and the co-author of the international bestseller The Molecule of More. His work explores one of the most powerful forces shaping our lives: the brain chemical dopamine — and how it influences motivation, ambition, and our constant drive for "more." Michael is also the author of Taming the Molecule of More: A Step-by-Step Guide to Making Dopamine Work for You. Over the course of his career, he has written speeches for members of Congress, presidential candidates, Fortune 10 CEOs, while also teaching at Georgetown University and producing award-winning screenplays. In our conversation, Michael explains why dopamine isn't actually the chemical that makes us happy, it's the chemical that makes us want more. More trips, more gadgets, more fun stuff on our phones. We discuss how this pursuit of "more" drives innovation and progress, but can also leave retirees feeling restless or unfulfilled if they're not careful. Michael also shares practical ways to recognize when dopamine is driving your decisions, how to create healthier habits that restore balance, and why learning to live more fully in the present moment can transform your experience of retirement. GET A FREE COPY OF MICHAEL'S BOOK, TAMING THE MOLECULE OF MORE Here's how: Step 1: Subscribe to the podcast and leave an honest rating & review on iTunes. Step 2: Text the word BOOK to 888-599-4491, and we'll send you a link to claim your free copy! In this podcast interview, you'll learn: Why dopamine isn't the "happiness chemical" — it's the chemical that drives our desire for more. How dopamine helped humans survive in a world of scarcity and danger. Why modern technology and social media can hijack your dopamine system. How retirees can redirect dopamine toward curiosity, purpose, and meaningful goals. The difference between dopamine (future-focused) and "here-and-now" brain chemicals. Simple habits that help reduce impulsive dopamine-driven decisions. Why learning to pause and appreciate the present moment can dramatically improve life satisfaction in retirement. Show Notes: HowardBailey.com/559

Butyrate is a short-chain fatty acid produced by the microbiome—and it plays a foundational role in gut health, inflammation control, immune system regulation, and even brain function. The problem? Most people today are deficient due to poor microbiome health, low fiber tolerance, and chronic gut dysfunction. Steven breaks down how butyrate supports the integrity of the gut lining, fuels colon cells, regulates oxygen levels in the microbiome, and creates an environment where beneficial bacteria can thrive. Without it, even the best diets and supplements may fall short.   TOPICS DISCUSSED: Butyrate: What It Is & Why It Matters Tributerin vs Standard Butyrate Diet Debate (Fiber vs Carnivore vs Vegan) Root Cause vs Symptom-Based Healing Failures of Probiotics & Supplement Industry Nervous System & Environmental Inputs   More from Steven Wright: Website: healthygut.com Instagram: @healthygutco   Leave us a Review: https://www.reversablepod.com/review   Need help with your gut? Visit my website gutsolution.ca to join a program: Get help now   Contact us: reversablepod.com/tips    FIND ME ON SOCIAL MEDIA: Instagram  Facebook  YouTube   

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with Sean Werner, Chief Technology Officer at BioLife Solutions,   Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with Sean, covering:   The value of learning your craft in big pharma, and the steep transition from technical expert to President of a spinout Why BioLife moved from board involvement to acquiring Sean's company outright The critical role of cryopreservation, and why it remains an overlooked risk in cell therapy development His perspective on the cell and gene therapy space, and why there is still plenty of reason for optimism The rise of China's biotech ecosystem and why its growth is a positive for the global industry Why CGT is set to diverge into more specialised areas, unlocking new therapeutic and patient applications   Sean Werner is the Chief Technology Officer at BioLife Solutions, a leading provider of bioproduction tools and services to the cell and gene therapy and broader biopharma markets. BioLife acquired Sexton Biotechnologies in 2021 where Sean was President of the company known for providing processing and handling solutions for the CGT industry. Sean received his PhD from Purdue University in Biology followed by post-doctoral positions at the Indiana University School of Medicine and Eli Lilly. Sean has previous experience filling various roles in the scientific, global regulatory, and general management functions supporting medical devices, autologous cell therapy, and single use disposable development programs. In his 23 years working in the life science industry, he has guided regenerative medicine research programs, pre-clinical and clinical testing and submission strategies leading to global commercialization of medical devices and bioprocessing tools and successful initiation of multi-national cell therapy clinical studies.   Molecule to Market is also sponsored by Bora Pharmaceuticals and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with Alessandro Maselli, President and Chief Executive Officer at Catalent and Franco Negron is the Chief Executive Officer at Simtra BioPharma Solutions.   Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology ecosystem with his esteemed guests during a live fireside chat at the DCAT Morgan Stanley CDMO CEO Dinner.   Alessandro Maselli is the President and Chief Executive Officer of Catalent, having assumed the CEO role in July 2022 after serving as the company's President and Chief Operating Officer since February 2019.  He has been with Catalent since 2010 and has played a central role in shaping the company into one of the world's leading contract development and manufacturing organizations serving pharmaceutical, biotechnology, and consumer health customers globally.   Alessandro joined Catalent as Director of Operations at the company's pharmaceutical, nutrition, and cosmetics facility in Italy. Over the course of more than a decade, he progressed through a series of increasingly senior leadership roles, including General Manager of the Zydis® operations in Swindon, U.K., Vice President of Operations for Europe within the Drug Delivery Solutions business, and Senior Vice President of Global Operations. In these roles, he oversaw multi-site global manufacturing networks, large-scale capacity expansions, and complex technology platforms across oral solid dose, biologics, and advanced delivery modalities.   As Chief Executive Officer, Alessandro led Catalent through the COVID-19 pandemic, during which the company played a critical role in the global response by supporting vaccine and therapeutic manufacturing at unprecedented scale. More recently, he has overseen Catalent's transition to private ownership following its $16.5 billion acquisition by Novo Holdings, positioning the company for long-term investment and growth as a privately held global CDMO.   Prior to joining Catalent, Mr. Maselli held a range of operational and business leadership roles at ABB Group, Alstom, and SGS, gaining extensive experience in industrial automation, engineering, and large-scale manufacturing operations. He began his career as an automation systems engineer in the food industry. In addition to his executive role, Alessandro serves on the Board of Directors of Graphic Packaging Holding Company, to which he was appointed in May 2025. He holds bachelor's and master's degrees in electronic engineering from the University of Rome and is a native of Italy.   Franco Negron is the Chief Executive Officer of Simtra BioPharma Solutions, a leading sterile injectable contract development and manufacturing organization formed following the divestiture of Baxter International's BioPharma Solutions business. He was appointed CEO in 2023 by Advent International and Warburg Pincus to lead the business as an independent, private-equity-backed CDMO focused on clinical-to-commercial parenteral manufacturing. Franco is an industry veteran with nearly 30 years of pharmaceutical and biopharmaceutical experience, bringing deep expertise across sterile manufacturing, commercial operations, and global supply chain leadership. Prior to joining Simtra, he served as Chief Executive Officer of ApiJect Systems America, a medical technology company focused on advanced drug-delivery and injection systems. Earlier in his career, he held senior executive roles at Thermo Fisher Scientific, where he served as President of Commercial Operations, and at Patheon Pharmaceuticals, where he was President of Development and Commercial Operations, North America, playing a key role in scaling Patheon's CDMO platform prior to its $7.2 billion acquisition by Thermo Fisher in 2017.   Franco has also held leadership positions at several major pharmaceutical companies, including Vice President of Manufacturing and Supply at Valeant Pharmaceuticals, Global Vice President within Novartis' Consumer Health division, and Site General Manager at McNeil Consumer Healthcare.   Across these roles, he developed a reputation for operational excellence, customer-centric leadership, and the ability to lead complex manufacturing organizations through periods of transformation and growth. As CEO of Simtra, Franco is leading the company through its next phase of expansion, focused on strengthening its sterile fill-finish capabilities, advancing technical differentiation, and investing in capacity to support increasing demand for injectable biologics, vaccines, and complex parenteral products   Molecule to Market is also sponsored by Bora Pharmaceuticals, and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

Today, I'm joined by David Roberts and Dr. John Gildea, two passionate researchers whose work sits at the cutting edge of environmental health and longevity science. In this episode, we dive deep into the catalyst for developing a stabilized sulforaphane supplement—something born out of both necessity and relentless curiosity. David opens up about how environmental toxicity stopped being theoretical for him, and Dr. Gildea brings a wealth of clinical insight into why supporting our detox pathways could be a game-changer for chronic disease prevention. Offer: Get 25% off stabilized sulforaphane products for a limited time at mara-labs.com/NAT with code NAT (offer ends April 7th 2026; 15% off thereafter).   Episode Timestamps: Welcome and podcast intro ... 00:00:00 When toxins became personal: cancer & environment ... 00:04:54 Practical detox: household and lifestyle changes ... 00:06:12 Sulforaphane's effect on inflammation and daily function ...00:07:07 Finding health solutions outside conventional medicine ... 00:14:44 Cancer diagnosis prompts sulforaphane stabilization ... 00:18:17 NRF2: master regulator in aging, skin, and detox ... 00:24:16 Sulforaphane, curcumin, and inflammation ... 00:25:11 Supplement confusion: sulforaphane vs. glucoraphanin ... 00:31:10 Food as medicine and practical dosing ... 00:34:51 Microplastics: exposure, health risks, and impacts ... 00:35:31 Detox routes and microplastics research ... 00:47:04 Glyphosate, NRF2 suppression, and gut barriers ... 00:52:54 Sulforaphane boosts detox and protects against pollution ... 00:59:13 GLP-1s, muscle loss risk, and supplement alternatives ... 01:00:08 Berberine: sleep, glucose, and microbiome effects ... 01:06:12 Synergies, future research, and sulforaphane limits ... 01:10:32 Sprouts, seeds, and potency of broccoli compounds ... 01:16:17   Our Amazing Sponsors: Vitali SkinCare - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.   Tro Zzz by Troscriptions – a fast-acting, customizable sleep formula designed to quiet racing thoughts and support deeper, more restorative sleep using a powerful blend of GABA-supporting compounds, cannabinoids, and sleep-promoting ingredients. Head to troscriptions.com, use code NAT10, and get 10% off.   Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Dr. Bill Lawrence Episode

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with: Jake Behrman, 3i Dirk Lange, Pyramid Pharma Hanns-Christian Mahler, ten23 J.D. Mowery, AST/Engage Sarah Stevens, Chrysalis   Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology ecosystem with his guests live from DCAT 2026. The event was hosted by Lead Candidate and sponsored by 3i private equity... and Molecule to Market,   Molecule to Market is also sponsored by Bora Pharmaceuticals and supported by Lead Candidate. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!

For this Saturday Show, Mike takes the guest seat on Lifelong with Ethan Suplee. Actor Ethan Suplee (Remember the Titans, My Name Is Earl) is well-known for his incredible physical transformation, having lost hundreds of pounds. Together, he and Mike get into a deep, candid discussion about the lifelong psychology of weight management, the economic politics of GLP-1 drugs, and why the extremes of the "Healthy at Every Size" movement veer into anti-science cultism. Plus, Mike reveals his biological "bliss molecule" advantage against anxiety. https://www.americanglutton.net/listen Produced by Corey Wara Video and Social Media by Geoff Craig Do you have questions or comments, or just want to say hello? Email us at ⁠⁠⁠⁠thegist@mikepesca.com For full Pesca content and updates, check out our website at https://www.mikepesca.com/⁠ For ad-free content or to become a Pesca Plus subscriber, check out ⁠⁠⁠⁠https://subscribe.mikepesca.com/ For Mike's daily takes on Substack, subscribe to The Gist List https://mikepesca.substack.com/ Follow us on Social Media:⁠⁠⁠⁠ YouTube https://www.youtube.com/channel/UC4_bh0wHgk2YfpKf4rg40_g⁠⁠⁠⁠ Instagram https://www.instagram.com/pescagist/ X https://x.com/pescami TikTok https://www.tiktok.com/@pescagist To advertise on the show, contact ⁠⁠⁠⁠ad-sales@libsyn.com⁠⁠⁠⁠ or visit ⁠⁠⁠⁠https://advertising.libsyn.com/TheGist