Podcasts about Myelin

Running a marathon is a bad idea—and in this episode, I explain why. I react to a shocking new study suggesting that during a marathon, the brain may actually consume myelin (the fatty insulation around nerve fibers) for fuel once glycogen stores run low. The researchers reassure us that the brain “bounces back naturally over time.” I’m not so reassured. I talk about the acute damage caused by marathon running—not just to the brain, but also to the heart, kidneys, hormones, immune system, and inflammatory response. I also go deeper into the long-term concerns around extreme endurance training: the diminishing returns of chronic cardio, why endurance training often fails as a fat-loss strategy, the “struggle and suffer” ethos of the endurance scene, and the opportunity cost of spending all your fitness energy shuffling down the road instead of building strength, power, explosiveness, and resilience. I explain why “what doesn’t kill you makes you stronger” is often misunderstood through the lens of hormesis and cumulative stress load, and finish with my preferred approach to lifelong fitness and longevity: walk more, lift weights regularly, and sprint once in a while. TIMESTAMPS: Running a marathon is a bad idea. Running those 26 miles can transform your brain. [01:05] Myelin is the fatty insulation around nerve fibers used as fuel when we run out of glycogen during a marathon. The brain fog one gets is caused by the loss of myelin. [02:24] Brad is looking at the stress on the brain as a result of metabolic myelin plasticity. [04:35] Long distance running places significant demands on the body and brain. [07:10] Numerous critical health immune inflammatory and cardiac biomarkers get temporarily blown off the charts even in the best prepared athletes, but more so in the recreational athletes. [09:45] If you were to go directly from crossing a marathon finish line to the nearest emergency room and have blood drawn, you would have the same lab results as someone suffering from a myocardial infarction, a heart attack. [10:47] There's also prominent research revealing how the immune system is suppressed for a significant period after the marathon. [14:15] The essence of peak performance and achieving bucket list goals is to do them correctly rather than drag a tired, unprepared body to the finish line. [17:58] One study suggests that conducting around two and half hours a week of endurance exercise comfortably paced is sufficient. [20:07] There's extensive and mounting research that endurance training simply does not work for fat loss. [22:14] An overuse injury is an obvious sign that the body is being overwhelmed and the training is not appropriate. [27:38] The obligate runner is one who has taken to the extremes similar to the anorexic needing control. [29:10] Effort and struggle are deeply satisfying when you're pursuing peak performance goals with honor and maintaining constant vigilance over your mental and physical health. [31:52] Putting all that energy to a narrow fitness goal like endurance training, precludes other far more valuable fitness endeavors. [33:53] Broad-based, full body fitness is the key to general health, vitality and longevity. Endurance competency is a small sliver of the big picture. [35:10] Shoes enable poorly adapted people to do an activity that they really shouldn't be doing. [37:16] Running a marathon is such an extreme challenge and it is very difficult to train in an appropriate sensible manner. A low-key casual approach can even lead to excellence in endurance training provided we don't succumb to these crazy influences that turn you into an obligate runner. [39:24] Is the old saying; What doesn't kill you, makes you stronger." really accurate? [43:47] You do not have to have sore muscles to grow stronger. Stress and breakdown are a byproduct of something you're doing to try and improve your health [46:27] You can get a detox effect from fasting but you can also improve your digestive system by just changing your diet. Or you can try a cold plunge. [47:24] Benefits come from the mechanical load or the cardiovascular load not the damage to the brain you get when you are overdoing it. [50:46] When thinking of a marathon, think about the pounding of the cement for 26 miles rather than a century bike ride or long distance hiking with low or no impact on your feet. [51:42] We want to create a fitness program where you spend a lot of energy on resistance training for your muscles and dedicate a portion to explosive efforts. [55:39] LINKS: Brad Kearns.com BradNutrition.com - 20% OFF Your First Order! B.rad Superdrink – Hydrates 28% Faster than Water—Creatine-Charged Hydration for Next-Level Power, Focus, and Recovery NEW: B.rad Real Rad Gummies - Creatine + Nootropics for Focus, Motivation, Performance, and Recovery! B.rad Whey Protein Superfuel - The Best Protein on The Planet! Brad’s Shopping Page BornToWalkBook.com B.rad Podcast – All Episodes Peluva Five-Toe Minimalist Shoes - Save 10% TED Tallk by James O'Keefe, M.D. Brad's Podcast with Dr. Joan Ifland Brad's Podcast with Cynthia Monteleone Jay Feldman Wellness.com WHAT RUNNING A MARATHON DOES TO YOUR BRAIN Does Marathon Running Harm the Brain? New Study Reveals Surprising Answer! Cognitive Benefits of Open-Skill Sports in Childhood: Evidence from the ABCD Study We appreciate all feedback, and questions for Q&A shows, emailed to podcast@bradventures.com. If you have a moment, please share an episode you like with a quick text message, or leave a review on your podcast app. Thank you! Check out each of these companies because they are absolutely awesome or they wouldn’t occupy this revered space. Seriously, I won’t promote anything that I don't absolutely love and use in daily life: B.rad Nutrition: Premium quality, all-natural supplements for peak performance, recovery, and longevity; including the world's highest quality whey protein! Get 20% OFF your first order! Peluva: Comfortable, functional, stylish five-toe minimalist shoe to reawaken optimal foot function. Use code BRADPODCAST for 15% off! Jaspr Air Scrubber: Ultra high-performance air purifier - blows other air filters away! Save $200 on your unit with code BRAD. Get Stride: Advanced DNA, methylation profile, microbiome & blood at-home testing. Hit your stride the right way, with cutting-edge technology and customized programming. Save 10% with the code BRAD. Online educational courses: Numerous great offerings for an immersive home-study educational experience Primal Fitness Expert Certification: The most comprehensive online course on all aspects of traditional fitness programming and a total immersion fitness lifestyle. Save 25% on tuition with code BRAD! #bradpodcastSee omnystudio.com/listener for privacy information.

Myelin may serve as an energy reserve for the brain, according to recent findings, prompting neuroscientists to rethink how the brain stores, shares and protects energy.

Silvia Messina, MD, DPhil / Michael Levy, MD, PhD - Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD) or Something Else? How to Tell the Difference

Silvia Messina, MD, DPhil / Michael Levy, MD, PhD - Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD) or Something Else? How to Tell the Difference

This inaugural episode of Mind the Meds introduces neurology pharmacy practice through a discussion between 3 neurology pharmacists working across inpatient and outpatient settings at the University of Utah. Host Erica Marini, PharmD, meets with her colleagues, Sarah Dahoney, PharmD, and Tyler Kenny, PharmD, BCCCP, both of whom are clinical pharmacists at the University of Utah Health, to discuss the research presented at the 2026 American Academy of Neurology (AAN) Annual Meeting. After sharing their diverse professional “origin stories,” the conversation then shifts to the role of pharmacists in neurology care and highlights key updates from the American Academy of Neurology annual meeting. The hosts discuss advances in neuromuscular disease, particularly myasthenia gravis, where emerging therapies such as FcRn inhibitors and CAR T-cell therapies are reshaping treatment paradigms. They also explore rare neurological conditions like stiff person syndrome and Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), where early-phase trials suggest promising but still preliminary therapeutic options. Finally, the episode reviews broader neurologic and systemic trends, including GLP-1 receptor agonists and SGLT2 inhibitors, noting potential but not yet definitive benefits in dementia prevention, stroke risk reduction, and migraine outcomes. Across all topics, the episode emphasizes the rapid evolution of neurological therapeutics and the expanding role of pharmacists in maneuvering complex, high-cost, and highly specialized treatments.Key Takeaways: Neurology pharmacy is highly collaborative and evolving, with non-linear career pathways. Pharmacists in neurology often enter the field through diverse experiences rather than a standardized training pipeline, and success depends heavily on adaptability, clinical curiosity, and initiative.  Pharmacists play a critical role in optimizing complex neurological therapies and care transitions. Their contributions span inpatient safety monitoring, outpatient medication access and affordability support, and ensuring continuity of care for high-risk, high-cost therapies.  Neurology therapeutics are rapidly advancing, but many emerging treatments remain early-stage. New therapies such as FcRn inhibitors, CAR T-cell approaches, and complement-targeting agents show promise across conditions like myasthenia gravis and rare neuroimmunologic diseases, while broader drug classes like GLP-1s are still under investigation for neurological benefits. 

Myelin repair is a natural function. But, for people living with MS, that ability to repair myelin eventually stops working. New research led by my guest, Dr. Larry Sherman, may explain why that happens and point to new possibilities for future myelin repair treatments. Dr. Sherman is a professor at the Oregon National Primate Research Center at Oregon Health & Science University, and his research focuses on how the brain and spinal cord respond to injury and disease, particularly in demyelinating conditions such as multiple sclerosis. We're also sharing some potentially good news for people living with non-relapsing secondary progressive MS in Europe, but not in the United States. We'll give you the details about an experimental drug that's just been submitted to the FDA and EMA for approval for treating relapsing forms of MS and primary progressive MS. We'll share the results of a study that focused on the impact of a cancer diagnosis on MS care. We'll tell you how Fernando Mendoza celebrated being named the #1 pick in this year's NFL draft. And we're sharing news about a new AI tool for your doctor. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: Why myelin repair stops working for people living with MS  :22 EMA's Committee for Medicinal Products for Human Use recommends approval of Tolebrutinib   1:35 Roche submits Fenebrutinib for FDA and EMA approval  4:45 Study results show the effect of a cancer diagnosis on MS care  6:13 The first pick in the 2026 NFL draft, Fernando Mendoza, partners with the National MS Society to launch the Mendoza Family Fund  9:43 OpenAI launches ChatGPT for Clinicians  10:56 Dr. Larry Sherman discusses why myelin repair stops working for people with MS, and how his team may have found a way to restart it  14:37 Share this episode  27:59 Next week  28:19 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/452 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes at www.RealTalkMS.com LISTEN: RealTalk MS Episode 440: An MS Specialist Responds to the FDA with Dr. William Conte https://realtalkms.com/440 STUDY: Impact of Cancer on Multiple Sclerosis-Related Healthcare and Disease-Modifying Drug Use: A Multinational Cohort Study https://journals.sagepub.com/doi/10.1177/13524585261437966 STUDY (Plain English Version): Impact of Cancer on Multiple Sclerosis-Related Healthcare and Disease-Modifying Drug Use: A Multinational Cohort Study https://tremlettsmsresearchexplained.wordpress.com/2026/04/23/impact-of-cancer-on-multiple-sclerosis-related-healthcare-and-disease-modifying-drug-use-a-multinational-cohort-study-explained DONATE: The Mendoza Family Fund (in Partnership with the National MS Society) https://nationalmssociety.org/how-you-can-help/ways-to-give/mendoza LEARN MORE: ChatGPT For Clinicians https://chatgpt.com/plans/clinicians AbleNOW https://ablenow.com JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on X, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 452 Guest: Dr. Larry Sherman Privacy Policy

00:00:00 Intro w/Myelin, Briar and Fran00:01:00 Watts In Japan and Write-Offs00:06:30 Briar's Hail Mary00:16:10 Grilling Performance (Anxiety) 00:27:10 The Marathon Mid-Season Grind01:06:00 Nintendo and Tariffs01:12:20 Assassin's Creed: Black Flag Resynced Hype01:27:30 Windrose01:32:40 The New Xbox: Game Pass Price Drops and NewsFind all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Familiarity with the clinical, MRI, CSF, and serologic features of MOGAD can help neurologists recognize this condition in clinical practice. Awareness of the utility and pitfalls of the MOG antibody test is critical. The current therapeutic approach is guided by retrospective studies and the application of immunotherapies used in other autoimmune neurologic disorders. In this episode, Gordon Smith, MD, FAAN, speaks with Eoin P. Flanagan, MBBCh, coauthor of the article "Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease" in the Continuum® April 2026 Multiple Sclerosis and Related Disorders issue. Dr. Smith is a Continuum® Audio interviewer and a professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Flanagan is a professor of neurology and the division chair of the Division of Multiple Sclerosis and Autoimmune Neurology in the Department of Neurology at Mayo Clinic in Rochester, Minnesota. Additional Resources Read the article: Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @GordonSmithMD Full episode transcript available here Dr Smith: So, what neurological disorder can cause bilateral optic neuritis, transverse myelitis, ADEM, or can mimic acute flaccid myelitis, intracranial hypertension, viral encephalitis, or cause seizures? Sounds like the great imitator, perhaps. If you want to know and learn more about this syndrome and how you can treat it---and it is very treatable---keep listening. My name is Gordon Smith, and today I have the great opportunity to talk with Dr Eoin Flanagan from the Mayo Clinic on his article on myelin oligodendrocyte glycoprotein antibody associated disease, or MOGAD, which is in the April 2026 issue of Continuum on Multiple Sclerosis and Related Disorders.  Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Smith: This is Dr Gordon Smith. Today I'm interviewing Dr Eoin Flanagan about his article on myelin oligodendrocyte glycoprotein associated disease, or MOGAD, which appears in the April 2026 Continuum issue on multiple sclerosis and related disorders. Eoin, welcome to the podcast, and please introduce yourself to our audience.  Dr Flanagan: Yeah, thanks so much. I'm Eoin Flanagan. I'm a neurologist at the Mayo Clinic. I'm originally from Ireland. I work in the neuroimmunology lab at the Mayo Clinic, and work and see patients with MS, MOG, and autoimmune disorders here in Rochester, Minnesota.  Dr Smith: Your article is super interesting, I think, and this has been a really rapidly evolving area over the last, you know, many years. We have many more antibodies, and MOG is something that's been around for a while, but we've certainly learned a lot more about it. This is a topic that I think will be familiar to most of our listeners, but I wonder if maybe you can just begin by laying the foundation. Like, what is MOG? What's its typical presentation?   Dr Flanagan: So, MOG is a protein on the surface of the oligodendrocyte or its CNS myelin, and it was always of interest as a potential antibody target, and initially it was investigated in multiple sclerosis. But subsequently, we recognized that the antibodies to MOG have a specific syndrome, of which about a quarter of patients are pediatric and then the remainder are adults. And they can present with a variety of syndromes, probably most commonly optic neuritis, but also acute disseminated encephalomyelitis, or ADEM. Transverse myelitis can also occur, and then some other unusual brain and brainstem cerebellar syndromes can also occur.   Dr Smith: I was really impressed in the very broad phenotypic spectrum of MOG. We'll talk more about that, of course. But I wonder if maybe you can tell us when we should be ordering MOG antibody? Given this broad variability, does anyone who has a CNS demyelinating disease need a MOG assay, only specific phenotypes? What guidance do you have for our listeners?   Dr Flanagan: Yeah. It's a great question. So, I think you have to be a little bit careful because the MOG antibody test is a little bit sticky. So sometimes we can see some low-positive false positives. So, we don't wanna order it in every single patient with classical MS. So, I suppose we'll start with who not to order it in. I think it's also a very optic nerve- and optic neuritis-central disease, so I think you really need to be considering this in a patient with optic neuritis who does not have lesions in the brain suggestive of multiple sclerosis. And then we think about some of the features: if the lesion, the enhancement along the optic nerve is long, if it's bilateral, if there's a lot of optic disc edema accompanying that, we tend to think about MOG antibodies. And then children with demyelinating disease, MOG is over-represented in that cohort, so it accounts for about a third of those. So, if you have a child with CNS demyelinating disease, particularly if they're under twelve, with ADEM presentations or other presentations, you probably want to be ordering the MOG antibody test. And then a longitudinally extensive transverse myelitis in adults, certain types of cerebral phenotypes that we can get into, you would want to consider ordering MOG antibodies too.   Dr Smith: Now, you point out in the article that it's really important that laboratories use the cell-based assay for MOG as opposed to an ELISA, for instance. Is this something folks need to be very attentive to, or are all of the commercial laboratories now using a cell-based assay?   Dr Flanagan: Yeah. I think all of the commercial labs are using cell-based assays, so we don't really get into much of an issue. There are some differences between serum and CSF, so really, serum is the optimal sample to order. There is also some differences between the live cell-based assay and the fixed cell-based assay, where the live cell-based assay may have some advantages in terms of sensitivity. And then CSF is kind of still under evaluation about its role in the condition. So in general, it's a serum test. And then we have to remember that the antibody tends to be highest at the onset, and then it goes down over time. So, if you delay your testing or you're testing a patient long after the condition, it can go negative, for example. So it tends to be highest both around the relapses and particularly at the onset of the condition.   Dr Smith: You mentioned earlier that the test is sticky, which I take to mean that there is some risk for low-titer false positives. How do you navigate that situation? When should we be suspicious about a false positive?   Dr Flanagan: Yeah. I think there's some very useful features that can help you. You know, the main differential diagnosis is going to be multiple sclerosis, particularly in the US, in regions of the northern US where MS is particularly common. So, you really wanna be making sure that if you get a positive result, low positive, that it's not multiple sclerosis. And some of the best discriminating features are CSF oligoclonal bands. They're about 85% in MS and about 15% in MOG, so an easy number to remember, 85 and 15. And then the lesions in MOG, the brain lesions, tend to disappear over time. So, if you have the advantage of that follow-up MRI a year down the line, about 70% of lesions in MOGAD will resolve, while in MS, as we know, the term means multiple scars, so the MS lesions tend to persist over time. So, they are two quite useful features that can help discriminate.   Dr Smith: And how about specific phenotypes or areas of involvement or imaging abnormalities that suggest MOG? One of the things I found really interesting in your article is there are a host of different syndromes that I think had largely been previously described, many of them, that became clear later that these were really tied to MOG antibodies. Presumably, that's helpful in interpreting the antibody assay in that patients who have, perhaps, a borderline low titer, for instance, but have a very typical phenotype are more likely to have MOG than those who have a more clearly MS-type phenotype.   Dr Flanagan: Yeah, absolutely right. Yes. So, there's certain phenotypes that we don't tend to see with MS. The acute disseminated encephalomyelitis, or ADEM, is one that's particularly common in children. And about half of people that have ADEM will be positive for the MOG antibody. So that's a syndrome you need to look out for, which would be often in children, encephalopathy, and they would have multifocal white matter lesions, sometimes involving the gray matter. A second syndrome that was an interesting discovery from a Japanese group was this unilateral cerebral cortical encephalitis, where patients can have this swelling and T2 hyperintensity, often just on one side of the brain. And it's in the cortex, and some of those patients won't have any white matter lesions. And in that situation, it's important to order the MOG antibody, and that seems to be a specific phenotype of MOGAD. But sometimes people don't think about it because the white matter is not involved. So, if you see these patients, they often present with seizures, sometimes they even have fever accompanied by it. And if you see those patients and see this radiological feature, then you really want to consider ordering the MOG antibody too.   Dr Smith: Yeah, I found that really interesting. And I- actually, my next question is perhaps a good follow-up on that, is, what are the diagnostic pitfalls? You give a lot of examples of situations and I think some cases where it's easy to get tripped up and misdiagnose someone who has MOG with another fairly common neurological problem.   Dr Flanagan: Yeah, I think some of the things that can help you when you're determining if the MOG is a true positive or false positive is the level of the antibodies. The super high titers, if it's a clear positive or very strong positive, the likelihood is that that is much more likely to be MOGAD than those low positives just above the cutoff. So that can be useful to help you discriminate from false positives. Those lesions, again, if all the lesions persist over time, that's going to be more suggestive of multiple sclerosis. Other diagnostic pitfalls, I suppose, if it's a syndrome that's not really associated with MOG, like peripheral neuropathy or other syndromes where we'll see some case reports, but usually I would be very cautious about those kind of presentations. So usually, having the antibody at a high level, and then also if they've had other symptoms suggestive of MOGAD, like if a patient has had recurrent optic neuritis and then they have an unusual brain syndrome, or they start out with an unusual brain syndrome and then have recurrent optic neuritis. You know, there are situations that make it more likely if they're having other typical phenotypes of the MOGAD where we can kind of expand the spectrum, but we have to be careful.   Dr Smith: I was really curious about the dynamic imaging findings. And you point this out both in terms of the resolution of imaging findings, but also in that patients who have an acute MOG syndrome often have very rapid evolution of the imaging abnormalities. I'm just curious, you know, why is that, and what do you make of it? Does it have a mechanistic implication, do you think?   Dr Flanagan: I don't think we know for sure. I think there's probably a lot more happening than we see on MRIs sometimes. What sometimes can happen in about 10% of patients is the initial MRI can be normal. We don't tend to see that with multiple sclerosis or NMOSD. Then what we see is it evolving over time. So, at that time, if you do a CSF, you'll often see inflammation, but we don't see the lesions. Now, that might be because the MRI is not very good at picking up cortical involvement. That can be difficult to see in MRI. Or there could be other factors. It could be a functional effect on the MOG but without frank demyelination yet, for example. Or there could be edema that you- myelin edema that you can't see as a lesion yet on MRI. But we do see that if you repeat the MRI, sometimes it'll change a lot. So, you may go from one or two lesions on the first MRI to twenty lesions on the second MRI a week later. So, it does tend to change a lot. And then over time, those lesions also resolve. So, what I say is if it's a very suspicious situation---like a child comes in with new-onset encephalitis, has inflammatory CSF---you might wanna consider repeating that MRI down the line and seeing if it's changing. And then over time, you know, a repeat MRI a year after the onset when there's brain or spinal cord lesions can be very helpful just to make sure you're on the right track, because lots of those lesions will then disappear, and that's a very clear discriminator from multiple sclerosis.   Dr Smith: Yeah, thanks. I mean, I was wondering the same thing about whether that particular feature might imply, you know, a functional abnormality as opposed to more of a structural abnormality. So probably a lot more to learn as we move forward. There are now consensus diagnostic criteria that were published a couple of years ago. I think you've already touched on kind of the general approach, but do you want to speak to those? I found your summary pretty helpful.   Dr Flanagan: Yeah, I think that those criteria are quite useful. They have three main parts to them. The first part is having a characteristic clinical syndrome. So, we talked about ADEM, we talked about cerebral cortical encephalitis, transverse myelitis that's often longitudinally extensive, and optic neuritis being the main syndromes, but sometimes other brainstem or cerebellar involvement can be seen. And then the second part is having a positive MOG antibody. And then there's some caveats there. So, if you have a high positive, then you don't really need any additional supportive criteria. On the other hand, if you're low positive, to get at those sticky antibodies that make sure it's not a false positive, you need some additional supportive clinical or MRI criteria. Or if you're only positive in CSF, you need that additional criteria. You also need to be negative for the aquaporin-4 antibody, because they can overlap clinically. And some of those supportive criteria are things that we talked about a little bit earlier, longer lesions within the optic nerve, bilateral involvement, involvement of the nerve sheath or optic disc edema. This is a situation, MOG antibody disease, where your fundoscope is useful and looking in the back of the eye and seeing swelling, because we don't tend to see that quite as often. It's less common in multiple sclerosis, but we often see prominent edema in MOGAD. And then in the spinal cord, the lesions tend to be central in the cord. Sometimes they form this H sign where it's restricted to the gray matter, and they tend to be longer, sometimes involving the conus. Patients will often have neurogenic bowel or bladder. And then in the brain, deep gray involvement, those large lesions along the cortex with swelling are some of the typical features. And then the final step is exclusion of another diagnosis. Just like with any test that we do in neurology, our final step is going to be to put that into context. So that's just a normal thing that we will always do when we get a group of test results back that we don't know what it means. We have to put it into context. So, make sure it's not multiple sclerosis, everything else does not look like multiple sclerosis, and then you can be on your way to make a diagnosis.   Dr Smith: Definitely encourage listeners to read your article. I guess I say that with every time I- or with everyone I talk to for Continuum Audio, but the images are really fantastic and the cases are fantastic. So, everything you've described is well-illustrated, including really nice schematic sort of diagrams that help differentiate NMO from MOG and MS. So, if you like MRI scans and good imaging frameworks, then this is the article for you.   Dr Flanagan: I think that's true, and the other thing is that the imaging is quite helpful because it takes a while for that antibody to come back. We're lucky at Mayo Clinic, if you work here, it, it comes back faster for you. But for many places, that time of sending it in, so a lot of times you don't know right away. So, looking at scrutinizing that MRI can be very helpful to guide you on your way and to know what you're dealing with and how to approach both the acute treatment and plans to have potentially a steroid taper after the acute treatment and those kind of things that can help guide you in that regard.   Dr Smith: Yeah. So, let's talk about treatment. You know, what's your approach to treating a patient who has an acute demyelinating syndrome related to MOG?   Dr Flanagan: So similar to other things, MOG is very steroid responsive. So, we use high-dose IV methylprednisolone in adults. That would be one gram IV for five days. And then we also will sometimes use oral steroids, twelve hundred and fifty milligrams. That's a bit of a hassle because it's twenty-five fifty-milligram tablets, it doesn't come in a larger tablet version. But it's very helpful to patients because they can get started on it right away. You don't have to set up an infusion center. So, we have used those oral steroids often in people who don't have access to an infusion center, are not in the hospital. And particularly as it's often optic neuritis, some of those patients are seen in the outpatient setting, so we can get in with treatment quickly. In patients where it's more severe, it doesn't recover quickly with steroids, then we would consider escalating to plasma exchange as our second-line treatment, and there's some retrospective data that suggests that plasma exchange can be useful. That's gonna be particularly for those people who don't have that quick response to steroids, or maybe more severe phenotypes like that brain involvement with ADEM or cerebral cortical encephalitis, where those patients might be in the hospital and quite unwell. I will say, we might get on to this, that sometimes MOG can be very, very severe and even fulminant, where there can be increased intracranial pressure, and these patients can be in the ICU, and it can be life-threatening. And so, it's really important to treat those patients aggressively, and some patients have even required hemicraniectomy or additional treatment. Sometimes IL-6 blocking medications have been used in that situation. So, monitoring and treating increased intracranial pressure in those rare patients, probably 2 or 3% that have the very severe attack, is important.   Dr Smith: I think one of the things I found interesting, and then I'd love to get your feedback on this, is that most patients with MOG seem to have a very readily treatable disorder that's monophasic, right? You treat them with steroids, and they do well. On the other extreme, there are these patients that have a much more malignant presentation, and there are some that sound like they benefit from prophylactic or some chronic therapy. What's your approach, right? In MS, we do serial scans to monitor, and obviously, our patients are on, you know, chronic disease-modifying therapy. How do you decide when you're going to provide some sort of prophylactic therapy? How do you monitor it? How long do you continue it?   Dr Flanagan: That's a great point. We don't know for sure yet, but I think for the most part, our approach has been if the patient has a single episode, they recover well from that episode. So, if that's optic neuritis, they're back to twenty/twenty vision. They have recovered well. We don't tend to use chronic maintenance immunotherapy. Sometimes after the first attack, we'll do a little bit of a slow taper, maybe over four, six weeks. We have done longer than that. And then we won't place them on any long-term treatment, because it's about 50% of patients that may have a monophasic disease, so we don't want to treat all those people who are destined never to have another relapse. On the other hand, if a patient had a very severe episode, they're in the ICU, they're intubated, some of those patients then afterwards we will start them at least temporarily on an attack prevention medication for at least a few years to get them through. Some patients will be very fearful of future relapses in that situation. Or if they don't recover well, if they're blind in one eye after an episode and then their other eye is vulnerable, or they're left with some residual deficits neurologically from a myelitis, then we would often sometimes put those patients after the first attack. But most of the time, we're gonna wait and see if they get that second attack, and then once they have the second attack, that is when we would consider a steroid-sparing medication. But I will say that there's no proven medications. We don't have any clinical trial data available yet. So some of those patients with relapsing disease, we'll either try to enroll them in a clinical trial, or we'll use an off-label treatment to try and manage their disease based on what we've learned from neuromyelitis optica or from multiple sclerosis. A few different options seem to be better, and we can maybe get into that too.   Dr Smith: Yeah, let's go there. So, what options are there? You mentioned in more fulminant disease IL-6 inhibitors, and by that I assume you mean tocilizumab, but what are the options when you want to use prophylactic therapy?   Dr Flanagan: So, that tocilizumab can be beneficial in the very acute situation, in that malignant situation. But also as an attack prevention treatment, the IL-6 blockers seem to- some of the retrospective data seems to look like it works reasonably well, so we work and see if we can get that approved. Another medication that can work well is IVIG or subcutaneous immunoglobulin as a maintenance treatment, so we would sometimes give that, like, at least one gram per kilogram once a month. The benefit of that is it doesn't lower your immune system, so there's some advantages there, particularly in people who may be more prone to infections, older people. So, we'll sometimes use that. But we do get into a lot of challenges with insurance coverage, and it can be difficult to get these approved by insurance because we only have retrospective data out there. So then for some patients, if they're in a region where there's a clinical trial available, we might try to enroll them in a clinical trial. And there are some clinical trials underway now, so hopefully in the future we'll be able to have some FDA-approved medications that can have some Class 1 data that we can follow. Because it's hard when you're just following retrospective data or anecdotal reports, it's a little bit difficult to know exactly how well you're doing with your treatments.   Dr Smith: Well, Eoin, I wonder if we could finish up by just looking into the future, right? I mean, it sounds like a fun patient population to take care of because you've got lots of great therapies and can have a durable impact. But sure would be nice to have more evidence-based therapies and an FDA approval. What trials are going on? What's the future look like?   Dr Flanagan: Yep. So, there's some trials going on in the- a couple of worldwide trials. One is on an FCRN blocker called rozanolixizumab, which is kind of like a plasma exchange-type treatment which removes your antibodies, and it's a weekly subcutaneous treatment where adults are enrolled. And the second one is called satralizumab, which is another IL-6 blocking medication. And again, that one's given once monthly under the skin. And the trial for that also includes children down to age eighteen, so for adolescents, too, that can be an option. There are trials, I believe, in Asia for tocilizumab too, and there's one starting in Australia for rituximab. So, the good news is that we're going to have some really good data down the line for lots of different agents, and we'll be able to figure out which treatments work. And this will be really of great benefit to our patients when we get that Class 1 data to kind of guide us on what we should be using and really build on the success of some of the other conditions like neuromyelitis optica spectrum disorder, where we now have four or five approved, medications that work very well.   Dr Smith: Well, Eoin, thank you. This is a great conversation. I will say that it... the topic that I was a little intimidated about. I'm a simple peripheral nerve guy, as you know. But I think moreso than any other Continuum article I've read recently, I'm, like, loaded for bear. I can't wait to go back on the inpatient service and look for some MOG patients, because your article really left me feeling kind of prepared to think through this in a clinical setting. So, thank you for the conversation, and congratulations on a really wonderful piece for Continuum.   Dr Flanagan: Yeah, thanks so much. Always a great honor to be involved in the Continuum, and thanks to all the readers out there.   Dr Monteith: This is Dr. Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Dr. R. Douglas Fields is Chief of the Nervous System Development and Plasticity Section at the National Institutes of Health (NIH) and Adjunct Professor in the Neuroscience and Cognitive Science Program at the University of Maryland, College Park. In addition, Doug is the author of numerous books and magazine articles about the brain, including the recently released book Electric Brain: How the New Science of Brainwaves Reads Minds, Tells Us How We Learn, and Helps Us Change for the Better. Doug studies how the brain develops and the mechanisms involved in changes to the brain's structure and function (plasticity). He is particularly interested in how experience regulates development and plasticity in the brain, as well as the mechanisms at a cellular level that are involved in learning. When he's not doing research or writing about science, Doug enjoys rock climbing, mountain climbing, building acoustic guitars, and making his own beer and wine. He received his B.A. in biology from the University of California, Berkeley, his M.A. degree in marine biology from San Jose State University, and his Ph.D. degree in marine biology from the University of California, San Diego, working jointly in the Medical School and Scripps Institution of Oceanography. Afterwards, Doug conducted postdoctoral research at Stanford University, Yale University, and the NIH before starting his research laboratory at the NIH in 1994. Doug is an elected Fellow of the American Association for the Advancement of Science, and he is the Founder and Editor-In-Chief of the scientific journal Neuron Glia Biology. In our interview, Doug tells us more about his life and science.

00:00:00 Intro00:00:30 Twitch Funerals?00:03:10 Briar Allergic to Laundry00:09:30 Myelin's Drunk Cockytail Streams00:13:10 Marathon & Cryo Archive00:25:10 Is Marathon A Hit?01:04:00 Crimson Desert01:22:55 Legend of California and Jeff Kaplan from Overwatch01:28:00 Briar GOLF Update01:35:00 Xbox ShowcaseFind all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

00:00:00 Intro w/Briar, TrueVanguard, Myelin, Ms5000Watts00:05:00 Farts and Sharts00:17:20 Steam Machine, PC and Console Delays00:21:00 Watts Arrives00:25:00 Football (American) Talk00:31:00 Granblue Fantasy: Relink Expansion00:33:20 Nintendo Direct Partner Showcase00:40:00 Horizon Hunters Gathering Co-Op Reveal00:58:20 Overwatch “Not 2”01:12:20 Nioh 301:30:30 Marathon Endgame Leaks?01:35:20 Highguard Updates and DramaFind all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

00:00:00 Intro w/ Briar, Ms5000Watts, Myelin, Fran00:05:00 Streaming Tech and Chat00:09:12 Worst Designed Console of All-Time00:15:30 Highguard Launch: First Impressions00:53:00 Titanfall 200:56:50 Code Vein II Early Access01:05:00 Nioh 3 Demo01:10:15 Darkhaven ARPG from Diablo 2 Vets01:13:00 Crimson Desert: Single-Player Open World ARPG01:18:30 Arc Raiders Roadmap Updates01:30:00 Marathon 01:35:00 Monster Hunter Wilds: Performance Fix01:39:30 Golf Updates with BriarFind all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

00:00:00 Intro00:01:45 Catching Up w/Myelin, Watts, Briar, TrueVanguard and Fran00:20:00 Best Games of 2025 Turbo Round00:42:10 Arc Raiders: Aggression-Based Matchmaking00:54:45 Best Games of 2025 Turbo Round (Cont'd)01:01:00 Fallout Rumors & More01:04:00 Myelin's Biggest 2025 Disappointment01:11:00 State of Monster Hunter Wilds 01:22:00 Wildgate01:23:00 Dune: Awakening01:24:00 Destiny 2: Renegades Fran's Quick Review01:34:00 Ghost of Yotei Disappointed Briar01:38:00 Discussing a Content Creator Showcase (New Game Plus)Join our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

00:00:00 Intro w/Watts, Myelin, Fran and Briar00:05:00 Hotel Lounges & Game Awards Socializing 00:15:25 Highguard Hate and Fran's Internet Fight00:47:30 Marathon's New Shine01:10:00 Arc Raiders Micros01:22:00 Terminator 2D: No Fate01:29:40 Monster Hunter Wilds Title Update 401:40:00 Warframe Updates01:43:00 Pragmata Demo01:49:30 Top Game Awards Picks Join our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

00:00:00 Back with Briar, Watts, TrueVanguard, Myelin, and Fran00:08:15 Elden Ring Nightreign DLC - Forsaken Hollows00:22:45 Marvel Rivals Updates w/Gambit00:30:13 Arc Raiders PVE-Only Mode?00:53:00 Ball x Pit 00:56:30 RV There Yet01:00:00 Destiny 2: Renegades Impressions01:33:00 The Game Awards Players' Voice Join our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

00:00:00 Intro w/Myelin, Watts, and Fran00:01:00 Is Briar a Dealer?00:02:30 Arc Raiders: Got Any Apricots?00:11:00 Nioh 3 00:24:00 Myelin's New Baby00:43:10 Destiny 2 Renegades New Info Coming00:47:00 Arc Raiders01:17:00 The Game Awards Nominees 202501:44:00 Silent Hill F01:44:30 Tides of Annihilation  01:48:30 Reanimal (Little Nightmares / Inside) 01:49:50 Total Chaos 01:53:00 Metroid Prime 4 Drama Join our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

A closer look at plasmalogensDetermining your healthy weightI'm having tight, painful cramps in my thighs while sleeping as well as standing after driving my car. Is this from dehydration?

Exercise—for those who hate exerciseDealing with post-exercise pain and fatigueIs there any treatment for Primary Progressive Aphasia?

00:00:00 Intro w/Briar, Fran, Myelin, Watts and TrueVanguard00:00:30 Myelin's PC Crashes Out and Burns Up00:13:00 Out of Time00:21:00 Mega Bonk00:27:00 Ghost of Yotei00:53:15 Destiny 2: Are People Quitting?01:26:00 Monster Hunter Wilds x FF14 Collab01:38:00 Silent Hill F Multiple Paths01:45:50 Xbox Game Pass Costs IncreaseJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

00:00:00 Briar, TrueVanguard, Watts, Myelin, Fran00:01:12 Fairy Bread w/ Myelin00:13:25 Silksong Impressions Continued00:39:31 Cronos Review w/ Fran00:51:00 BioShock Series00:56:30 Borderlands 4 Impressions01:31:10 Destiny 2: The State of Things01:43:26 Elden Ring DLC in ReviewJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Nutritionist Leyla Muedin discusses the crucial role of iron in the body. She explains iron's importance in producing hemoglobin for oxygen transport, supporting the immune system, and ensuring overall energy levels. Leyla delves into iron's impact on brain health, cognitive function, and mood regulation, and discusses the differences between heme and non-heme iron in foods. Emphasizing the need for balance, she warns against both deficiency and excess iron, and highlights groups at higher risk for iron deficiency. Listeners are encouraged to get their iron levels checked and consult healthcare professionals for appropriate supplementation.

How do you keep chasing your purpose when life hits you with a diagnosis that changes everything?In this deeply inspirational and motivational episode, Reginald D sits down with rapper, producer, author, and entrepreneur Robert Cardillo, better known as B-Cide, to talk about his raw, real, and resilient journey living with Multiple Sclerosis (MS)—while still pursuing his passion for music, entrepreneurship, and impact.From growing up in upstate New York, grinding in the underground hip hop scene for over 25 years, and building his streetwear brand “55 Strong,” B-Cide opens up about what it truly means to fight for your purpose, even when your body tries to betray you. Diagnosed with MS in 2011, he shares the emotional toll, the reality of lost relationships, and how he rose again—stronger, wiser, and louder than ever.B-Cide's story is more than music—it's about faith, mental strength, and redefining success when life doesn't go according to plan.Whether you're battling chronic illness, invisible pain, or internal doubt—this episode will remind you that you are not your diagnosis, and you still have a voice.Powerful TakeawaysLearn how to transform adversity into art and advocacy—and how B-Cide channels MS into a groundbreaking album set to drop during MS Awareness Month.Discover how to redefine success beyond fame or fortune—through purpose, connection, and legacy.Get inspired by B-Cide's practical wisdom on how to push through physical and emotional pain while staying creative, resilient, and faith filled.If you've ever felt like life knocked you off course, hit play now for a motivational/inspirational speech wrapped in real-life experience, hip hop wisdom, and purpose-driven fire.B-Cide contact info:Official Website: https://www.b-cide.com Book Website: https://www.myelinmyshoes.com Instagram: https://instagram.com/bcide Facebook: https://facebook.com/bcide TikTok: https://tiktok.com/@bcide YYouTube: https://youtube.com/@btvstudio Bandcamp: https://bcide.bandcamp.cominspirational, motivational, motivational podcast, motivational speech, MS awareness, multiple sclerosis, chronic illness motivation, invisible illness inspiration, hip hop artist, , underground rap, Myelin My Shoes book, B-Cide, overcoming adversity, living with MSSend us a textSupport the showFor daily motivation and inspiration, subscribe and follow Real Talk With Reginald D on social media:Instagram: realtalkwithreginaldd TikTok: @realtalkregd Youtube: @realtalkwithreginald Facebook: realtalkwithreginaldd Twitter Real Talk With Reginald D (@realtalkRegD) / TwitterWebsite: Real Talk With Reginald D https://www.realtalkwithreginaldd.com Real Talk With Reginald D - Merchandise

00:00:00 Slang for Robots w/Briar, Myelin, TrueVanguard and Fran00:08:00 007 First Light Gameplay and Release Date Reveal00:27:45 Silksong00:33:30 Shinobi 00:42:08 Cronos: The New Dawn00:55:00 Hell Is Us00:56:11 Myelin Plays League of Legends01:01:00 Destiny 2 Updates and Destiny: Rising01:16:50 Marvel Rivals Next Season01:28:30 Space Marines 2 Big Update Coming01:33:50 Metal EdenJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Neurologist Michelle Monje studies the close relationship between cancer and the nervous system, particularly in an aggressive brain cancer that often strikes in childhood. Her research shows that the cancer cells are electrically integrated into the brain itself and these connections actually help the cancer to grow. Monje and collaborators have now developed an immunotherapy that has shown great promise in mice and early human trials. One patient had a “complete response” and is cancer-free four years after treatment, Monje tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Michelle MonjeConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Michelle Monje, a professor of pediatric neurology at Stanford University.(00:03:39) Focus on Cancer ResearchMonje's clinical observations led to exploring cancer-neuron interactions.(00:05:28) Neurons and Glial CellsThe role of neurons and glial cells in brain function and disease.(00:08:32) Gliomas in ChildrenAn overview of gliomas and their origins in glial precursor cells.(00:10:12) Rethinking Brain Cancer BehaviorHow gliomas don't just grow—they integrate with brain circuits.(00:14:49) Mechanisms of Tumor GrowthTwo primary mechanisms by which cancer exploits the nervous system.(00:16:32) Synaptic Integration of Cancer CellsThe discovery that glioma cells form synapses with neurons.(00:20:06) CAR T-Cell TherapyAdapting CAR T-cell immunotherapy to target brain tumors.(00:22:52) Targeting GD2 AntigenIdentification of a surface marker enables precision CAR T-cell therapy.(00:24:35) Immune Access to the BrainThe ability of CAR T-cells to reach the brain, despite prior understanding.(00:26:16) First Clinical Trial ResultsThe significant tumor reduction and response from CAR T-cell therapy.(00:28:21) Combined TherapiesPairing immune therapy with neural signaling blockers for better outcomes.(00:30:35) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

00:00:00 Power of Vacation w/Fran, Myelin, and Watts00:07:20 Wuchang with Watts and Panty Despair00:14:25 4 Hours w/ Ninja Gaiden00:22:30 Battlefield 6 Beta: Early Impressions00:54:00 Sony PlayStation Tightening Control of Bungie01:02:30 Pokemon Trading Card Art Theft Oopsie?01:05:15 Grounded 2 Early Access and Crashout01:12:00 New Nightreign Hard Boss and Duos01:26:00 DK Bananza Impressions01:31:00 Fran Tries Destiny 2: Edge of FateJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWatts00:00:00 Briar's Back from Court w/Fran, Watts, Myelin and TrueVanguard00:07:45 Sagat and Street Fighter 600:08:40 New Pragmata News from Capcom00:16:00 More Street Fighter 6 Details00:18:20 Resident Evil 900:24:20 Monster Hunter Wilds News00:38:00 Mario Kart World Patch00:44:40 Briar Loves Ninja Gaiden: Ragebound00:58:30 Chrono Odyssey MMO01:05:15 Destiny 2 Edge of Fate Dev Stream and Armor 01:32:00 Mecha Break01:33:00 Borderlands 4 Hype is Real01:41:30 Death Stranding 2 ReleaseArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWatts00:00:00 Briar's Out, What Could Go Wrong (Watts, Myelin, and Fran)00:05:00 The Dangers of A.I.00:11:50 Marathon Delayed Indefinitely, Officially00:39:00 Division 1 Survival Mode00:42:45 Destiny 2 Edge of Fate Dev Livestream00:49:00 Nightreign Hard Boss Update00:55:10 FBC: Firebreak Reviews01:24:00 NextFest Demos and Indies01:45:30 The Alters01:51:00 DK Bananza Direct01:58:30 Chrono Odyssey Action MMOArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWatts00:00:00 Briar Asks: Cops Are Here…What Do You Do? (w/ Myelin, Briar, Watts, TrueVanguard, and Fran)00:09:40 Lies of P DLC Impressions & Arc Raiders News00:13:30 Back to Lies of P DLC00:28:00 Nightreign and Elden Ring Shadow of the Erdtree00:32:00 Nioh 3 Demo00:36:30 TrueVanguard on Obsidian's Grounded 200:40:00 Mortal Shell 2 - Summer Games Fest00:42:20 Chronicles: Medieval00:43:10 Code Vein 200:46:20 Atomic Heart 200:47:30 The Cube00:48:55 Chrono Odyssey00:51:20 Mecha Break00:54:45 Wuchang00:56:00 Wu-Tang: Rise of the Deciever00:57:20 Resident Evil 9 Hype01:02:20 Stranger Than Heaven01:04:00 Onimusha: Way of the Sword01:06:00 Pragmata Demo Getting Hype01:07:00 Ninja Gaiden 4 - Xbox Showcase01:09:10 Outer Worlds 201:11:30 Call of Duty: Black Ops 701:13:00 Clockwork Revolution01:16:00 Beast of Reincarnation from Game Freak01:19:00 ROG Xbox Ally X01:28:00 Blood of Dawnwalker01:29:00 Aniimo01:30:00 Crisol: Theater of Idols01:32:30 Next Fest Demos01:38:30 Splitgate 2 … Myelin Disconnects KEKL01:39:45 MindsEye01:43:10 Splitgate 2: Battle Royale01:52:00 The AltersArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWatts00:00:00 Briar's Amazing Intro … feat. Watts, Myelin, and Fran (and Bears)00:10:40 Destiny 2: Edge of Fate Details and Hands-on Previews00:24:30 Switch 2 & Mario Kart World00:53:00 PlayStation State of Play: Lumines00:55:30 Pragmata from Capcom00:57:20 Romeo is a Dead Man from Suda 5101:00:10 Silent Hill F01:03:00 Bloodstained01:06:00 Digimon Story Time Stranger01:07:00 Final Fantasy Tactics - Ivalice Chronicles01:08:50 Baby Steps01:10:22 Nioh 301:18:52 Thief VR01:19:40 Tides of Tomorrow01:20:30 New Astro Bot Levels01:21:30 Sea of Remnants01:22:30 New Astro Bot Levels01:23:30 Sword of the Sea01:25:30 007 First Light01:27:40 Ghost of Yotei Gameplay Deep Dive Coming01:28:10 Marvel Tokon from Arc System Works01:29:40 PlayStation Fight Stick01:37:00 Nightreign Impressions Update01:58:30 Arc Raiders Soon?Art by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWatts00:00:00 Intro with TrueVanguard, Watts, Briar, Myelin, and Fran 00:00:30 Weirdest Sport Outfits and Power-Walking00:09:40 Nightreign First Impressions00:39:30 Marathon Madness Continues 00:57:10 Marvel Rivals00:58:30 Monster Hunter Wilds Collab x SF601:05:00 Division 2 New DLC w/ Myelin01:33:00 Fran Finally Plays Shadow of Erdtree DLC for Elden Ring01:37:00 Lies of P DLC01:38:10 Star Wars: Battlefront 2 Resurgence 01:46:00 Wrapping UpArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWatts00:00:00 Intro with Watts, Myelin and Fran & Sake00:03:00 Ms5000Watts: Getting Partnered on Twitch00:08:30 Marathon Madness, Art Plagiarism and More00:43:50 FBC: Firebreak Preview with Fran00:49:45 Monster Hunter Wilds X Street Fighter Collab01:00:00 Lies of P DLC - Overture01:03:10 DOOM: The Dark Ages Review01:25:45 Expedition 33 Nearly Complete: Watts' Fave of All-Time?01:37:05 First Time with Division 2 with Myelin01:52:40 Deliver at All Costs01:53:30 Game Like “Papers, Please” - Quarantine Zone DemoArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s

This week the crew is back!00:00:00 Tefty Returns for Marathon… Blaze It00:01:00 Myelin's Judo Chop Gone Wrong00:10:50 Marathon Playtest Alpha00:14:30 Marathon: Watts Has Trouble Getting a Code00:19:30 Marathon Impressions01:29:45 Clair Obscure: Expedition 33 (“French JRPG”)01:37:30 Oblivion Remastered Launches 01:41:00 FBC: Firebreak Rlease Date01:42:30 Runescape: Dragonwilds01:44:45 Blue Prince01:46:35 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back!00:00:00 419 Part One w/ Myelin, TrueVanguard, Watts, Fran (FM3)00:01:00 Drinking and Podcasting00:04:00 First Berserker: Khazan Full Impressions w/Watts & Briar00:20:30 Bungie's Marathon Mystery Returns00:26:30 Nintendo Switch 2 Full Reveal00:27:30 Switch 2: Wild Hearts00:30:30 Switch 2: Hollow Knight - Silksong00:32:30 Switch 2: Duskbloods (FromSoft Exclusive)00:48:20 Switch 2: Mario Kart World 00:58:20 Switch 2 Hardware01:04:20 Switch 2 vs. Switch Compatibility01:06:20 Switch 2 Prices, the Mouse and More Reactions01:18:50 Switch 2: Donkey Kong Bananza01:20:30 Switch 2 Cont'd01:33:00 Soulframe (from Warframe Creators)01:38:17 Switch 2: Mario Kart World 01:48:20 Destiny 2 Episode III Act 3 Launches--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back!00:00:00 Intro00:00:30 DCP+ Podcast PPP w/ Watts, Briar, TrueVanguard, Myelin, Fran (FM3)00:03:30 Assassin's Creed Shadows and Its Leveling System00:26:00 Cyberpunk 2077 Love (But Briar Won't Play It)00:27:40 Wildgate (Ex-Blizzard Devs): Playful Spaceship Extraction Shooter00:39:55 Myelin's World of Warframe00:44:00 Metroid Prime 4 and Nintendo Switch Direct00:57:00 When Rental Stores Died01:04:20 FBC: Firebreak (Control Spin-Off) Release Date and Preview01:07:00 Severance01:11:00 Haunted Houses and Ghosts and Phasmophobia 01:16:30 Darktide Update01:17:10 Monster Hunter Wilds - Title Update1 Preview01:23:00 Path of Exile 2 Big Update01:30:00 First Berzerker of Khazan Impressions w/Watts01:43:00 Destiny 2 Act II Finale – Act II Begins Next Week01:56:00 Now Streaming…01:58:20 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back!00:00:00 Intro00:00:15 How is Myelin with casual nudity?00:02:55 Catching up with the crew: Briar, TrueVanguard, Ms5000Watts, Fran (FM3)00:03:00 The Capcom Cup00:11:30 Vacation Cruisin' with TrueVanguard and the Best Pina Colada of His Life00:18:00 Monster Hunter Wilds & Is It Too Accessible or “Dumbed Down”?00:41:00 What Are the Rules of Monster Hunter?00:47:00 What Makes Monster Hunter Wilds So Great?00:53:15 Split Fiction w/Myelin00:56:30 No Rest for the Wicked Updates (Early Access)01:05:45 Elder Scrolls Oblivion Remake?01:10:00 New Silent Hill F 01:16:15 Shinobi Art of Vengeance Gets Release Date01:19:00 Destiny 2: Guardian Games, Act II Launches, Rite01:37:41 Space Marine 3 Announced01:39:30 Marvel Rivals Addictions Continue01:43:00 Other Stuff01:44:40 Expedition 33 Demo01:47:00 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back!00:00:05 When Does a Walk Become a Hike? (Briar, TrueVanguard, Myelin, Fran)00:04:35 Monster Hunter Wilds Beta #200:13:45 Myelin's Message to the D2 Community (and Warframe)00:24:10 Destiny 2: Heresy Episode 3 Arrives00:44:45 New Street Fighter 6 Character00:55:50 Kingdom Come: Deliverance 201:06:45 Too Many Games 01:10:23 Battlefield Labs + Going Big01:11:00 GTA 6 on Track, Avowed Next Week01:25:00 2025 A Big Year: Switch 2, Metroid Prime 401:33:30 Civilization 7 & More01:34:41 Marvel Rivals Update with TrueVanguard01:43:00 Judas Is Coming01:48:00 Questions from Social --------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back!00:00:01 Then There Were Three… Ms5000Watts, Myelin, and Fran (FM3)00:02:33 Myelin Gets Roasted by a Fan & Content Creation Notes from the Crew00:12:45 Episode Heresey…00:28:30 Monster Hunter: World Grabs Fran & New Wilds News00:48:28 Ninja Gaiden 2 Black00:55:00 Onimusha and Capcom Spotlight Coming Next Week01:07:30 Nvidia RTX 5080 and 50-Series Launches01:17:30 Path of Exile 201:24:30 Destiny 2 Star Wars Collab01:29:30 Eternal Strands Released01:34:00 Dune MMO Preview01:36:30 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back!00:00:01 Back after 3 weeks of holidays: TrueVanguard, Myelin, Ms5000Watts, Briar00:30:01 Catching up, X-Mas gifts, and remodeling 00:12:45 Nvidia's New RTX 5000s and CES00:26:50 Watts' reactions to multi-streaming on YouTube and Twitch00:40:50 Destiny 2 Act 3 Impressions and This Week in Destiny00:45:30 Monster Hunter Wilds Beta(s) Coming Soon1:00:00 Path of Exile 21:03:45 Assassin's Creed Shadows Delayed1:06:30 Indiana Jones and the Great Circle (Mini Fran Review)1:08:22 Marvel Rivals Season 11:20:00 Prince of Persia: The Lost Crown 1:27:00 Coming Soon…1:33:30 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back!00:00:01 Tefty RETURNS w/Briar, Ms5000Watts, Myelin and Fran (FM3)00:06:07 Destiny 2: Teft's First Reactions to The Final Shape (...and Lightfall)00:20:10 Destiny 2: Teft's First Reactions to Onslaught00:26:01 Marathon31:30:00 Project Gummy Bears and the Sony Acquisition33:30:00 Sony and Kadokawa35:45:00 PS5 Pro42:40:01 Monster Hunter Wilds Cometh53:00:00 Indiana Jones and the Great Circle1:01:00 Teft's Shortlist of Games to Play: Black Ops Zombies and …1:23:00 Diablo 4 and Path of Exile 21:29:45 Elden Ring: Nightreign Spinoff Game (and Elden Ring: Shadow of the Erdtree)1:42:00 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back!00:00:01 Back from Friendsgiving: Briar, Watts, Myelin, Fran (FM3)00:03:01 Tefty Streams Return (and he Played Destiny) 00:06:40 Next week: The Game Awards Stream00:08:35  What Game Awards Trailers Are Coming?00:13:30 Monster Hunter Wilds Hands-On Event00:24:00 Path of Exile 2 Early Access is Arriving00:44:00 Indiana Jones and the Great Circle is Out00:47:30 Balatro 00:54:01 Stalker 200:59:31 Astro Bot Speedrun01:01:30 Dauntless Scandal: Hits Steam with Negative Reviews01:08:40 Infinity Nikki Dress-Up Game01:12:00 Destiny 2: The Dawning and Iron Banner Stasis Sidearm01:21:00 Street Fighter 6 Patch: Buffs and Incoming New Character01:24:30 Marvel Rivals01:28:30 Light of Motiram… Steals Horizon's Looks (free-to-play open-world multiplayer survival game)01:46:20 Questions from Social --------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back for episode 406!00:00:01 Watts, Briar, Myelin and Fran Return00:02:31 Destiny 2: Tomb of Elders, Revenant Act 2 Story & More00:12:58 Bomb Cyclone Hits Northwest & Bungie HQ00:15:46 Stalker 2 Impressions with Briar00:31:40 The Game Awards Nominees & Elden Ring DLC00:59:00 Black Myth: Wukong So Far… Fran About 80% In1:09:34 Stellar Blade is Stellar Reminder from Watts1:11:00 Sony May Buy Kadokawa (Crunchyroll… From Software…)1:20:15 The Last Faith1:22:30 Pokemon Trading Card Game (TCG) Pocket1:30:15 Supervive1:35:42 Halo: Infinite - Returning with Myelin1:42:14 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back for episode 405!00:00:01 The crew is back with TrueVanguard, Myelin, Watts, Briar, Fran (FM3)00:00:20 Something About Dandadan's Balls00:02:45 The Tyson-Paul Boxing Match00:06:20 Dragon Age: Veilguard with TrueVanguard 00:10:45 Destiny 2: Revenant Act II, Prison of Elders returns, Street Fighter collab and more00:27:00 Destiny 2: PVP and Sandbox Updates00:48:00 Pokemon TCG Pocket… PVP00:50:00 Stalker 2 Release 00:52:00 Slitterhead First Impressions with Ms5000Watts01:00:00 Wukong: Black Myth Impressions with Fran1:08:13 The Game Awards and GOTY Nominees Are Coming1:12:55 Monster Hunter Outlanders Mobile Game Announced1:17:20 F1 2023 and Story Mode with Briar1:35:43 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back for episode 403!00:00:02 Ms5000Watts, Myelin, Fran (FM3) and Briar00:03:30 Knockoff: The Battle for Imagination demo: kickstarter fighting game00:06:00 Growing up, watching cartoons, and going outside to play00:14:22  Monster Hunter Wilds Beta PC impressions50:15:00 Dragon Age: The Veilguard impressions01:02:00 Still Wakes the Deep (Watts' scary water game begins)01:05:30 Frostpunk 2 with Briar01:15:30 New Once Human Raid with Myelin01:22:30 PlayStation 5 Pro Release Date1:33:30 Destiny 2: Act 2 Revenant Livestream and Destiny Rising has SRL01:46:00 Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------

This week the crew is back for episode 403!00:00:01 - Watts, Briar, Myelin and Fran with the Halloween costumes00:01:35 - Monster Hunter Wilds beta first impressions00:48:43 - Destiny 2: Weight-Gate Fixes, Festival of Lost and Fran Tries New Dungeon00:58:48 - Streaming Show: Devil's Hour with Briar, and Myelin Starts Severance01:04:55 - Marathon Dev Update Reactions1:16:40 - Questions from Social--------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel!https://www.twitch.tv/dcp_live/Our Patreon is now LIVE!https://www.patreon.com/dcp_liveJoin our DCP Discord Server!https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP"https://scufgaming.com/----------------------------------------------------------------------------------------------------------------Find all of the DCP Members on Twitter: @teft | @TheBriarRabbit | @myelingames | @Mrs5oooWattsaArt by Ash: @AR_McDSocial Media and Twitch Management by Mr_Ar3s: @Mr_Ar3s--------------------------------------------------------Join us on our DCP LIVE Twitch Channel! https://www.twitch.tv/dcp_live/Our Patreon is now LIVE! https://www.patreon.com/dcp_liveJoin our DCP Discord Server! https://discord.gg/dcp--------------------------------------------------------We have a new merch store! Exclusive t-shirts and more incoming!https://store.streamelements.com/dcp_liveSave 5% on Scuf Gaming with code "DCP" https://scufgaming.com/--------------------------------------------------------