Podcasts about Brain

Most people are using AI to get more done in less time. But what if the way you're using it is quietly making you more dependent on technology and less confident in your own ability to think?AI can organize information, generate ideas, and complete tasks in seconds. But when you rely on it to make every decision, solve every problem, and produce every answer, you miss opportunities to develop the skills that make you valuable: judgment, creativity, critical thinking, communication, and adaptability.In this episode of the Kwik Brain podcast, I share the Brain-First AI Method, a practical system for using artificial intelligence to strengthen your human intelligence. I'll show you how to protect your attention for meaningful work, communicate with AI more effectively, challenge your assumptions, and practice important skills before you need them in the real world.You'll also learn how to use AI as a personal learning coach, so you can build expertise, prepare for new opportunities, and continue growing as technology changes.After this episode, you'll have a practical way to use AI that goes beyond saving time. You'll know how to use it to prepare for bigger opportunities, make more informed decisions, and build the knowledge and skills that help you grow in your career and your life.☀️Order my new book: https://limitlessdaily.com/ See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Text and Be HeardYour phone is not “just showing you ads” anymore. It's training your brain to chase a dopamine hit, and sports betting companies are paying celebrities and influencers to make that chase look normal.We get real about the explosion of gambling marketing, including the hype around sports betting in Texas, and why we call many of these promos what they are: addiction dressed up as entertainment. We talk about how compulsive gambling can light up the brain like an upper, why “you cannot outthink an emotional issue,” and why constant exposure can be a serious trigger for people in recovery. If you've been searching for clarity on gambling addiction, sports betting addiction, problem gambling, or how to stop gambling, we connect the dots between the psychology, the business model, and the emotional costs.We also unpack the influencer economy behind it all: athletes, actors, comedians, and models becoming the front door to an industry that reportedly spends billions on advertising. Then we challenge the most common hook in the playbook: “deposit a little, get a lot.” Nobody gives away free money, and we explain why those sign-up bonuses exist and who ultimately pays for them.These Influencers are Drug Dealers.  Cocaine and Gambling light up the Brain the same way.  No difference.If this hit home, share the episode with someone who's being targeted by these ads, subscribe for more recovery-centered conversations, and leave a review so more people can find it. What's the most aggressive gambling promo you've seen lately?Support the showRecovery is Beautiful.   Go Live Your Best Life!!Facebook Group - Recovery Freedom Circle | FacebookYour EQ is Your IQYouTube -    Life Is Wonderful   Hugo VRecovery Freedom CircleThe System That Understands Recovery, Builds Character  and Helps People Have Better Relationships.A Life Changing Solution, Saves You Time, 18 weekswww.lifeiswonderful.love  Instagram -  Lifeiswonderful.LoveTikTok -  Lifeiswonderful.LovePinterest -   Lifeiswonderful.LoveX -     LifeWonderLoveLinkedIn -   Hugo Vrsalovic    LinkedIn -   The 1% in Recovery

The average man today is walking around with meaningfully less testosterone than his grandfather had at the same age — and the fix the military is reaching for may be aimed at the wrong target.Dr. Mark Gordon returns to Men Talking Mindfulness for his third appearance to unpack the quiet war on male hormones. He's a pioneer of hormone-and-brain medicine, Medical Director of the Warrior Angel Foundation, and featured in the documentary Quiet Explosions. This episode centers on a live policy moment: a Pentagon directive associated with Defense Secretary Pete Hegseth that would screen service members over 30 for low testosterone and offer TRT, with the goal of a more capable, resilient force. Dr. Gordon shares the good news underneath the headline — the goal is right, and the biology is fixable — while making a clinical case that simply injecting testosterone is the wrong target, because it shuts down the body's own ability to produce it. Jon and Will dig into what actually drives low T, why everyday ibuprofen may be quietly part of the problem, and the root-cause path that restores a man's own hormone engine.IN THIS EPISODE, YOU WILL LEARN:1.  Why the average man today carries far lower testosterone than his grandfather did — and what's driving the decline2.  The Pentagon's proposed directive (tied to Secretary Hegseth) to screen service members over 30 for low T and offer TRT — and Dr. Gordon's clinical case for a smarter target3.  How everyday NSAIDs like ibuprofen (“vitamin M”) can quietly interrupt the brain's signal to make testosterone — and how to work around it4.  Why blast and TBI exposure can leave blood testosterone looking “normal” while brain hormone production is devastated — and why an injection can't reach that5.  The root-cause approach that restores your own production — pulsed clomiphene, calming inflammation and cortisol — instead of shutting your system downMore about Dr. Mark Gordon:1.  Educational site: https://www.tbihelpnow.org2.  Store (10% first-time discount, funds veteran treatment): https://www.millenniumhealthstore.com3.  Neurosteroid hormone paper — available on his website and Instagram4.  Documentary: Quiet Explosions: Healing the Brain — featuring Dr. Gordon and the Warrior Angel Foundation5.  Book: Peptides for Health — available via millenniumhealthstore.com (00:00) - Cold open (01:18) - Welcome to Men Talking Mindfulness (01:27) - The 60-second version: why testosterone is falling (02:11) - Meet Dr. Mark Gordon (03:26) - One-breath grounding practice (04:04) - Hormones 101: what the endocrine system does (06:14) - What disrupts your hormones (10:15) - 'Vitamin M': the military's ibuprofen habit (10:58) - How ibuprofen shuts down the testosterone signal (12:02) - Selenium and Brazil nuts: reversing the damage (16:13) - The Pentagon's TRT directive - and Mark's objection (17:10) - What ten years of veteran data shows (19:43) - What an 'optimal' testosterone level really is (21:39) - Fertility, Clomid and dosing mistakes (24:32) - Case file: Quiet Explosions (27:38) - Hormones and psychedelic-assisted therapy (30:53) - The brain's own pharmacy (36:10) - Breaking the NSAID wall (38:22) - Brain injury, LH and reading the labs (42:34) - Inflammation, pain and peroxynitrite (44:20) - What a listener can do without a military-grade panel (47:31) - Reversing MS: Tim's story (50:50) - First steps for a new patient - and what it costs (53:59) - Closing thoughts and where to find Dr. Gordon Check out our Awareness-to-action Self Mastery COURSE & COMMUNITY:12 modules on attention, presence & performance. Work at your own pace plus a community built for Inspiration and connection.1.  www.focusnowtraining.com/a2a-CourseJOIN US IN PERSON — Future Events and Retreats.1.  Live in-person event: Warrior Defined. We will be in Charlotte, NC, September 25, 2026 more info HERE: Or mentalkingmindfulness.comGET MORE FROM MTM:Text MTM to 33777 — free weekly newsletter1.  Subscribe: mentalkingmindfulness.com2.  FNT: focusnowtraining.comBRING FNT TO YOUR TEAM:1.  focusnowtraining.com/contactProduced by Robert Lopez | https://www.cratesaudio.com/

The claim that women need more creatine is everywhere right now, especially if you're strength training over 40.Maybe you heard that women carry 70 to 80% lower creatine stores than men, so you need a bigger dose.What about bone health (especially in postmenopause), brain health, and loading? How much should you actually take and when? What will creatine do for you?Get those answers and more, including:The REAL reason creatine worksWhy “lower creatine stores” does not mean depleted muscle creatineHow sex-specific high-dose claims fall apart at the tissue levelWhat the research actually shows for strength and lean mass in older adults and older womenThe reality of bone density, cognition, mood, and higher dosing benefits of creatine based on the researchThe best type of creatine (hint: it's the cheapest too) and how to dose itCreatine myths on weight gain, bloating, hair loss, and kidneys (plus how it affects your bloodwork)If you take creatine, you're thinking about starting, or you've been told you need more of it than men do, hit play.Try Fitness Lab (exclusive link for 20% off), the AI coaching app that reads your data, coaches you on your patterns, and keeps you consistent for adults over 40 who want to lose fat and build strengthTimestamps:0:00 - Should you take creatine at all? 2:12 - The big social media claim about women and creatine 3:13 - Where the 70 to 80% number comes from 8:27 - The ONE thing that makes creatine worth taking 9:57 - How much creatine adds to your performance and muscle 13:06 - Creatine and bone density 15:05 - Brain and mood benefits of creatine 17:44 - Creatine dosage and loading 20:08 - 3 creatine mythsEpisode Resources:Menopause Fat Loss Over 40 - free guide on setting up your calories, protein, and training through perimenopause and after

Dr. Esther Walker, PhD, shares the science behind why cycling boosts brain health and mental performance. She breaks down the short‑term neurochemical spikes and the long‑term structural changes that riding can trigger, while addressing common myths about “bike as therapy.” You'll gain practical guidance on how to harness cycling for focus, mood, and overall cognitive resilience.Key Takeaways - A 20‑minute ride can increase pre‑frontal cortex activity, improve attention, and release dopamine and serotonin.- Consistent, moderate cycling builds hippocampal volume and reduces dementia risk more effectively than occasional high‑intensity sessions.- Cycling is a powerful tool, not a cure‑all; combine it with therapy, medication, or community support for best results.- Accessibility matters: welcoming environments, skill‑building, and adaptable equipment (e‑bikes, trikes) expand participation across ages.- Track your rides: start with 10‑20 minutes weekly and gradually add “pennies” to your mental‑health piggy bank.Esther Walker, PhD is the Executive Director of Outride, a nonprofit advancing brain health through cycling. With a PhD in cognitive science, she bridges academic research and real‑world bike programs for youth, adults, and older populations.Links & Resources - Outride website: https://www.outridebike.org- Outride Instagram: @outride- Recent JAMA study on commuting cycling & hippocampal volume: https://outridebike.org/research-resourcesIf you found these insights valuable, hit subscribe so you never miss a science‑backed episode, leave a 5‑star review to help fellow entrepreneurs discover the show, and join the conversation on Instagram @outride. Let's ride smarter together!Courses and Coaching: https://livefeisty.com/courses/Sign up to Receive The Feisty Women's Performance Newsletter:Feisty Women's Performance Newsletter: https://livefeisty.com/newsletters/feisty-womens-performance/Follow us on Instagram:@feisty_womens_performanceSupport our Partners:Momentous: Head to https://www.livemomentous.com/ and use promo code PERFORMANCE for up to 35% off your first orderWahoo: Learn more about Wahoo Fitness Products at: https://wahoofitness.pxf.io/0GAByRTifosi Optics: Use code FEISTY2026 for 20% off at https://tifosioptics.com/Hettas: Use code STAYFEISTY for 20% off at https://hettas.com/ Orca: Use the code FEISTY15 for 15% off at https://orca.avln.me/c/HzUkzIfxsmYo

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Try Longevity Gummies: https://www.timeline.com/partners/dave-aspreyIf you're waking up exhausted, foggy, or inflamed and nothing seems to fix it, the answer might be hiding in your walls. This deep dive walks through how toxic mold and mycotoxins settle into your brain, nerves, and mitochondria, how to properly test your home and body for exposure, and the exact order of operations, environment first, then detox, that actually leads to recovery. Drawing from his own diagnosis with mold-related brain damage, the creator breaks down everything from HVAC contamination to binders and glutathione so you can finally stop chasing symptoms and address the real source.Thank you to our sponsors!Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighNeuronic | Go to www.neuronic.online Code DAVE for $100 offiRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVETimestamps:00:00 — Mold Toxins and My Story02:14 — How Mycotoxins Damage Cells04:09 — Three Sources of Mold05:35 — Track Symptoms by Location07:20 — Fix Environment Before Detox08:53 — Mold Testing Methods10:35 — Remediation and Moisture Control12:47 — Belongings Can Recontaminate14:45 — Why Recovery Varies17:23 — Detox Protocol and BindersConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

EVEN MORE about this episode!Your brain is constantly deciding what deserves your attention—but could your thoughts and beliefs be influencing what you notice every day? Julie Ryan talks with entrepreneur and Positive Activity™ co-creator Lori Rogers about how changing what she focused on transformed the way she responded to fear, uncertainty, caregiving, and some of the most difficult challenges of her life.Lori once described herself as a chronic “worrywart.” Then several crises collided: her business was struggling, her daughter suffered a severe concussion, and her son with autism was approaching adulthood. Instead of allowing fear to dictate what happened next, Lori began experimenting with simple daily practices involving gratitude, kindness, movement, meditation, and intentional focus.Julie and Lori explore the reticular activating system (RAS) and the role attention plays in determining which information we consciously notice. They discuss how repeated patterns of thought can influence our attention and behavior—and why changing those patterns may help us respond differently to the world around us.But this conversation goes much deeper than positive thinking.Lori explains why forced positivity doesn't work, how fear can interfere with intuition and decision-making, and why she began looking at difficult experiences as happening for her rather than simply to her.She also shares the remarkable story of her adult son Craig, who is nonspeaking and communicates through spelling. Lori describes the profound messages he has shared with her about God, love, consciousness, and the nature of life, and why she now considers him one of her greatest spiritual teachers.Julie and Lori also explore conscious creation, spiritual guidance, resilience, caregiving, manifestation, and a simple morning practice designed to help interrupt habitual thought patterns before they take over the day.If you've ever felt trapped in worry, fear, negative thinking, or circumstances you can't control, this conversation explores what may change when you become more intentional about where you place your attention.Guest Biography:Lori Rogers is the president and co-founder of Rogers Marketing, a multimillion-dollar woman-owned business where, for more than 25 years, she and her team have built lasting client relationships, driven franchise-leading sales, and earned recognition for leadership in their industry. She is also the caregiver of her adult son, who was diagnosed with autism, an experience that inspired her advocacy for individuals with special needs and their families. Lori co-founded PASE—Parents Assisting Special Educators—to provide vital equipment and supplies to special education classrooms and teachers, and founded Life-Op to create safe, productive learning environments for adults with special needs. A passionate Spelling to Communicate (S2C) advocate, Lori has dedicated herself to expanding opportunities and support for nonspeaking individuals. In 2011, she began incorporating the practices of Positive Activity™, experiencing profound shifts in both her professional success and her approach to caregiving. Today, she shares these principles with others, teaching simple daily practices and mindset shifts designed to foster greater positivity, possibility, and meaningful transformation in business, caregiving, and everyday life.Episode Chapters:(0:00:00) Can Your Thoughts Change the Life You Experience? (0:06:27) Your Brain Is Filtering More Than You Realize (0:09:31) How Fear Can Block Intuition & Guidance (0:12:45) The Crises That Forced Lori to Change Her Thinking (0:23:01) Her Nonspeaking Son Became Her Spiritual Teacher (0:37:47) Simple Daily Habits That Can Shift Your Mindset (0:56:00) Are We Consciously Creating Our Lives? (1:02:44) The 2-Minute Morning Shift to Start Tomorrow➡️Subscribe to Ask Julie Ryan YouTube➡️Subscribe to Ask Julie Ryan Español YouTube➡️Subscribe to Ask Julie Ryan Português YouTube➡️Subscribe to Ask Julie Ryan Deutsch YouTube➡️Subscribe to Ask Julie Ryan Français YouTube✏️Ask Julie a Question!

Dr. Michael Roizen returns for Part 2 of the conversation on longevity, healthspan, and the future of healthy aging. Building on the previous discussion, he dives deeper into The Great Age Reboot and the emerging science behind extending not just lifespan, but years of health, mobility, and vitality. From brain health and stress management to nutrition, movement, purpose, and the latest advances in longevity research, Dr. Roizen shares practical steps people can take today while exploring what the future of medicine may make possible tomorrow.  Key Takeaways:   Healthy aging is shaped by the daily choices we make long before we reach older age.  Brain health benefits from movement, cognitive challenges, stress management, and meaningful engagement.  Nutrition, physical activity, and healthy metabolic markers are important foundations for longevity.  Purpose, friendship, and play can help support a healthier and more fulfilling life as we age.  Emerging advances in gene editing, stem cell research, and other longevity therapies could reshape how we approach aging in the future.   We couldn't highlight incredible stories like this without the support of our sponsor, CommunityAmerica Credit Union. Thank you for helping us promote connection, well-being, and stronger communities. If you're looking for trusted financial wellbeing resources, we invite you to connect with their team and take the next step toward greater financial confidence.  About Dr. Michael Roizen:   Dr. Roizen served as Cleveland Clinic's first Chief Wellness Officer from 2007 to 2019 & founding Chair of its Wellness Institute. The Clinic's Wellness Programs helped the clinic not spend over 1.250 billion dollars for its 101,000 employees & dependents over 11 years compared with national averages and help over 43.6% of participants achieve 6 normals+2 ® for health. This reduced their rate of aging and time of disability equivalent to 12.5 years over an 80 year lifespan.    Dr Roizen is a recipient of an Emmy, an Elle, the Paul Rogers best medical communicator award from the National Library of Medicine, & the Bennett Family Award from GlobalWellnesSummit. He initiated & developed the RealAge concept to motivate behavior change. That started the concept that 60 could be the new 40. He believes that soon 90 will be the new 40—how you can prepare for it is described in his recently released book and app-newsletter, The Great Age Reboot and 4 YOUngevity.com Ai coaching program & free newsletter.    He has authored over 195 peer reviewed scientific publications (he really is a science nerd), four New York Times #1 best sellers, 9 overall top 10 bestsellers including his initial #1 Bestseller in 5 countries, "RealAge: Are You As Young As You Can Be?", "AgeProof—Living Longer without breaking a hip or running out of money" and his book that displaced Harry Potter from #1 on Amazon for 177 days, YOU: On A Diet, The Owner's Manual for Waist Management. He served 16 years on FDA advisory committees, including chairing one for two years. His books have been translated into 44 languages and been number 1 in 5 countries in addition to the USA. He helped start 14 companies including his current Therapeutic Plasma Exchange Company, Lifespan-Edge.com, , co-invented a drug approved by the FDA, co-invented the Cloud (US Patent # 2004/0205055A1 ; his coinventor –who took it from him—was just awarded 673 million dollars from Amazon)and has a weekly podcast now in its 1268th+ week; he and Dr Oz coauthored a daily column syndicated to over 68 newspapers that translates current scientific reports into actionable steps for lay audiences. When Dr Oz declared his candidacy for public office, Dr Roizen has continued the column alone, but have recently started writing it together again, but he has restarted alone as Dr Oz is now USA's CMS Director-Administrator.    He is a recipient of The United Way of Cleveland Humanitarian of the Year Award. He has won over 75 trophies in class A squash competition. His wife is a developmental pediatrician also listed in the Best Doctors in America. The Roizens have two children: Jenny, a PhD organic chemist working for the US Energy Department, and Jeffrey, an MD/PhD faculty member in pediatric endocrinology at Children's Hospital of Philadelphia. Dr. Roizen is devoted to helping people live younger. He consults with patients in Cleveland Clinic's Executive Health and Wellness Programs. He teaches them the 80% likelihood that they can be 40 at calendar age 90, and how to prepare for that.   Connect with Dr. Michael Roizen at:   https://4youngevity.com/    https://lifespan-edge.com/   https://michaelfroizenmd.substack.com/   Connect with Dr. Michelle and Bayleigh at:  https://smallchangesbigshifts.com  hello@smallchangesbigshifts.com  https://www.linkedin.com/company/smallchangesbigshifts  https://www.facebook.com/SmallChangesBigShifts  https://www.instagram.com/smallchangesbigshiftsco  https://www.youtube.com/@smallchangesbigshiftsco    Thanks for listening!  Thanks so much for listening to our podcast! If you enjoyed this episode and think that others could benefit from listening, please share it using the social media buttons on this page.  Do you have some feedback or questions about this episode? Leave a comment in the section below!  Subscribe to the podcast  If you would like to get automatic updates of new podcast episodes, you can subscribe to the podcast on Apple Podcasts or Stitcher. You can also subscribe in your favorite podcast app.  Leave us an Apple Podcasts review  Ratings and reviews from our listeners are extremely valuable to us and greatly appreciated. They help our podcast rank higher on Apple Podcasts, which exposes our show to more awesome listeners like you. If you have a minute, please leave an honest review on Apple Podcasts. 

The more I talk about the perfectionist mindset and our perfectionist brains, the more misconceptions I hear.  In this Best of The Podcast episode, I'm sharing some of the biggest misconceptions about perfectionism to help you understand your perfectionist brain and learn how to work with it, instead of against it. If you're a perfectionist and you're building a business, you want to listen to this episode today. If you're ready to get out of your own way in your business, you want to join my coaching program Perfectionists Getting Shit Done (PGSD). Sign up now at samlaurabrown.com/pgsd. To learn how to plan out your week in a way that works with your perfectionist brain, sign up for my free 5-Part Planning Series here: samlaurabrown.com/planningseries.

Constant notifications can train you to react instead of intentionally focus. Every interruption pulls your attention away from what you were doing, and repeatedly responding to those interruptions can make distraction feel normal. The solution is to protect your attention by reducing unnecessary notifications and creating uninterrupted time to think and work. Show Notes: [09:52]#1 Your attention gets hijacked. [13:28]#2 Your brain starts craving the interruption. [18:38]#3 Deep thinking requires long periods of nothingness except thinking. [24:23] Recap Next Steps: --- Execution is not a talent.   It is a standard. If your results don't match your ability, something in your approach is out of alignment. Most people do not have a motivation problem.   They have a consistency problem. Power Presence is the system for operating with greater discipline, clarity, structure, and execution under pressure. Learn more: → http://www.PowerPresenceProtocol.com  Know what to do but not always doing it?  Measure your execution at → http://RateMyExecution.com. Get Dre's free Daily Game email at http://WorkOnMyGame.com. Every day you'll receive one practical lesson on leadership, mindset, discipline, and execution to help you perform at a higher level. No fluff. Just game

This episode explores how to approach the scale during binge eating recovery. There isn't one right answer about whether or how often to weigh yourself, and Kathryn guides you in deciding what works best for you. You'll learn why impulsive or compulsive weighing can increase preoccupation and make recovery more difficult, as well as how to handle the thoughts and urges that may come up when you do choose to weigh yourself. Most importantly, you'll learn how to keep the scale from interfering with the two main recovery goals: eating adequately and dismissing urges to binge.   Join the Brain over Binge Group Get $60 off of your first month with the coupon code: FREEDOM99 BrainoverBinge.com/Weight/ Brain over Binge resources: Get the Free Starter Kit (includes the Inspiration Booklet) Get personalized support from Kathryn with one-on-one coaching Subscribe to the Brain over Binge Course for only $18.99 per month Get the Second Edition of Brain over Binge on Amazon and Audible, BarnesandNoble.com, Apple iBooks, or Kobo. Get the Brain over Binge Recovery Guide   Disclaimer: *The Brain over Binge Podcast is produced and recorded by Brain over Binge Recovery Coaching, LLC. All work is copyrighted by Brain over Binge Recovery Coaching, LLC, and all rights are reserved. As a disclaimer, the hosts of the Brain over Binge Podcast are not professional counselors or licensed healthcare providers, and this podcast is not a substitute for medical advice or any form of professional therapy. Eating disorders can have serious health consequences and you are strongly advised to seek medical attention for matters relating to your health. Please get help when you need it, and good luck on your journey.

It's a crumb! Get the gist in a few minutes. Check out the other mini vids (new!) on Patreon!

On a new episode of The Fellas on this Fox Football Saturday with Anthony Gargano & Geoff Schwartz, the guys talk about Geoff's Ducks 84-0 win over Portland State, Texas Tech's narrow win over Houston, and Miami defeating Wake Forest, and preview the rest of CFB week 3. The Fellas then give their thoughts on Josh Allen and the Bills early season dominance and look at NFL Week 2. They then dive into LSU and Lane Kiffin's huge matchup against Ole Miss. Brad “The Brain” Feinberg jumps on with the fellas & MORE! See omnystudio.com/listener for privacy information.

Could Lyme disease and other chronic inflammatory triggers play a role in Alzheimer's disease—and could addressing those underlying factors change measurable Alzheimer's biomarkers? In this episode of the Tick Boot Camp Podcast, Dr. Richard Horowitz returns to discuss a provocative new case report he published exploring the relationship between Lyme disease, neuroinflammation, Alzheimer's disease biomarkers, and dapsone combination therapy. The conversation centers on a patient with a long history of Lyme disease who had an elevated phosphorylated tau 217 (p-tau217) level, an increasingly important blood biomarker associated with Alzheimer's disease. After completing a nine-week dapsone combination protocol, the patient's p-tau217 declined by approximately 63% and returned to the normal range. Her amyloid-beta 42/40 ratio also moved in a favorable direction, and she reported improved cognitive clarity. This case provides a new research question: Could infections, toxins, metabolic dysfunction, sleep disorders, microbiome disturbances, and other inflammatory drivers contribute to Alzheimer's pathology in subsets of patients—and could identifying and addressing those drivers change the course of the disease? Read the Published Study Read Dr. Horowitz's published study on SAGE Journals The case report provides the scientific foundation for much of the discussion in this episode, including the changes in p-tau217 and amyloid biomarkers following treatment. In This Episode, You'll Learn Lyme Disease and Alzheimer's Disease Dr. Horowitz reviews research that has investigated possible relationships between Borrelia burgdorferi, neuroinflammation, amyloid, phosphorylated tau, and Alzheimer's pathology. Much of the earlier work examining spirochetes and Alzheimer's disease involved brain tissue and postmortem studies. Dr. Horowitz explains why he believes studying Alzheimer's biomarkers in living Lyme disease patients may provide another way to investigate these questions. The discussion also explores an important distinction: finding an association between infection and Alzheimer's pathology does not mean every case of Alzheimer's disease is caused by Lyme disease. The Patient Who Sparked the New Case Report Dr. Horowitz describes a longtime patient with Lyme disease whose p-tau217 was substantially elevated despite her perception that her cognition was relatively good. After the patient underwent his nine-week dapsone combination protocol, repeat testing showed a substantial reduction in p-tau217, bringing the biomarker into the normal range. Dr. Horowitz also discusses changes in the patient's amyloid-beta 42/40 ratio, rheumatoid factor, and subjective cognitive function. The case led him to ask whether treatment directed at persistent infection and inflammation could influence biomarkers normally associated with Alzheimer's disease. What Is p-Tau217? A major portion of the interview focuses on the emerging use of blood-based biomarkers for evaluating Alzheimer's pathology. Dr. Horowitz discusses four primary biomarkers: p-tau217 – phosphorylated tau 217 p-tau181 – phosphorylated tau 181 Amyloid-beta 42/40 ratio Neurofilament light chain (NfL) He also discusses GFAP (glial fibrillary acidic protein) and the potential relevance of APOE genetics. Dr. Horowitz describes p-tau217 as one of the most sensitive and specific currently available blood biomarkers associated with Alzheimer's disease pathology. Amyloid May Be More Than Just “Plaque” Why does amyloid accumulate in the brain in the first place? The episode explores the concept of amyloid-beta as an antimicrobial peptide and the hypothesis that amyloid production may, in some circumstances, be part of the brain's response to biological threats. Dr. Horowitz discusses research examining potential infectious and environmental contributors to amyloid production, including: Borrelia and other bacteria Viral infections Fungal organisms Other microbes Environmental toxins The conversation then explores how a response that may initially be protective could potentially become harmful when amyloid accumulates and interferes with normal neuronal function. Amyloid, Tau and Neurodegeneration Dr. Horowitz breaks down two major features associated with Alzheimer's disease. Amyloid-beta plaques accumulate outside neurons and are associated with disrupted communication between brain cells. Tau proteins normally help stabilize structures inside neurons. Abnormally phosphorylated tau can become associated with neuronal dysfunction and neurodegeneration. The discussion also explores why some patients may have abnormal tau biomarkers without corresponding abnormalities in amyloid markers—and why much more research is needed to understand these patterns in people with chronic Lyme disease. Dapsone Combination Therapy and Cognitive Symptoms Dapsone has been a major focus of Dr. Horowitz's research into persistent Lyme disease. In this episode, he explains that his protocols involve combination therapy rather than dapsone alone and discusses his previous published work examining dapsone combination therapy in patients with persistent Lyme disease symptoms. According to Dr. Horowitz, improvements in memory, concentration, cognition, and word-finding difficulties have repeatedly been among the most notable improvements reported in his patient cohorts. He believes this observation deserves greater attention now that blood-based Alzheimer's biomarkers make it possible to investigate biological changes alongside cognitive symptoms. Dapsone, the Brain and the NLRP3 Inflammasome The discussion goes beyond dapsone's antimicrobial activity. Dr. Horowitz explains his interest in the NLRP3 inflammasome, an inflammatory pathway implicated in neuroinflammation and studied in relation to Alzheimer's disease. He proposes that dapsone could potentially have more than one relevant effect—targeting certain microorganisms as part of combination therapy while also influencing inflammatory pathways. This remains an area requiring further clinical investigation. Alzheimer's Disease May Have Multiple Drivers One of the most important themes of the interview is that Alzheimer's disease is unlikely to have a single universal cause. Dr. Horowitz applies his 16-point MSIDS (Multiple Systemic Infectious Disease Syndrome) model to cognitive decline and Alzheimer's disease. Potential contributors discussed include: Lyme disease and other infections Mold and mycotoxin exposure Heavy metals and environmental toxins Chronic inflammation Insulin resistance and blood sugar dysregulation Sleep disorders and sleep apnea Gut microbiome dysfunction Nutritional deficiencies Mitochondrial dysfunction Cardiovascular and metabolic factors Other sources of systemic inflammation Rather than focusing exclusively on amyloid or tau, Dr. Horowitz argues for investigating what may be driving those abnormalities in an individual patient. Lyme Disease Is Not the Only Possible Infectious Trigger The episode also examines the broader question of infection and neurodegeneration. Dr. Horowitz discusses scientific literature investigating organisms and infections beyond Borrelia, including Chlamydia pneumoniae, Helicobacter pylori, Coxiella burnetii, herpesviruses, and other microbial exposures. His central argument is not that every Alzheimer's patient has an infection. Instead, he believes clinicians and researchers should investigate whether infectious, toxic, metabolic, environmental, and inflammatory factors may coexist and contribute differently from patient to patient. The Challenge of Lyme Disease Testing The conversation also addresses limitations surrounding Lyme disease diagnostics. A negative standard Lyme disease test does not necessarily answer every clinical question surrounding prior exposure or persistent symptoms. The hosts and Dr. Horowitz discuss why testing methodology, timing, immune response, strain diversity, clinical history, and other factors may need to be considered when evaluating a complex patient. Dr. Horowitz also explains how he combines laboratory findings with clinical history and his MSIDS framework when evaluating patients. Why More Data Is Critical A single case can generate a hypothesis. It cannot establish a treatment standard. Dr. Horowitz repeatedly emphasizes the need for: Additional documented cases Standardized biomarker testing Long-term patient follow-up Larger patient cohorts Collaboration among Lyme-literate physicians and neurologists Shared research databases Multicenter studies Randomized controlled clinical trials The episode explores the possibility of physicians systematically collecting Alzheimer's biomarkers before and after treatment of specific MSIDS factors to determine which interventions, if any, consistently change those biomarkers. That type of data could help researchers move beyond individual clinical observations toward testable conclusions. Could Patient Data Accelerate Lyme and Alzheimer's Research? Matt and Dr. Horowitz discuss the potential for a secure research repository where physicians could contribute standardized patient data. For example, researchers could track a patient's infections, mold exposure, metabolic factors and other MSIDS variables alongside p-tau217, p-tau181, amyloid-beta 42/40 and NfL measurements. Repeating those measurements after individual interventions could help researchers identify patterns that would otherwise take years to discover through isolated clinical practices. Dr. Horowitz Is Developing an MSIDS App Dr. Horowitz also shares a major project currently in development. He says he is working with researchers from the University of California, Irvine on an application designed to translate his MSIDS framework into a digital tool. The goal is for users to enter information based on the MSIDS questionnaire and other health data, allowing the software to help guide them through the framework. Dr. Horowitz also discusses how a sufficiently large and secure database could eventually create opportunities for collecting real-world patient data and generating new research hypotheses. Lifestyle, Metabolic Health and Brain Health Not every potential driver discussed in this episode is infectious. Dr. Horowitz highlights several established areas of brain-health research, including: Mediterranean/MIND-style dietary patterns Regular physical activity Healthy blood sugar and insulin regulation Cardiovascular health Adequate sleep Addressing sleep apnea Omega-3 fatty acids Nutritional status Gut and microbiome health This reinforces one of the episode's central messages: cognitive decline may result from multiple interacting biological pressures rather than one isolated mechanism. Ending Chronic Illness The discussion also previews Dr. Horowitz's upcoming book, Ending Chronic Illness, scheduled for publication on October 13, 2026. The book expands on his 16-point MSIDS model and explores how overlapping infectious, inflammatory, environmental, metabolic, immune, neurological, and lifestyle factors may contribute to chronic disease. A separate Tick Boot Camp interview dedicated to the new book will be released this fall. Learn More About Dr. Richard Horowitz Dr. Richard Horowitz is one of the best-known physicians in the Lyme disease community and has spent decades treating patients with Lyme disease, tick-borne infections, and complex chronic illness. Tick Boot Camp has interviewed Dr. Horowitz multiple times about Lyme disease, Babesia, Bartonella, dapsone combination therapy, MSIDS, chronic inflammation, and emerging research. Visit Dr. Richard Horowitz's Tick Boot Camp page for all of our interviews, articles, and resources Additional Resources Explore all Tick Boot Camp interviews and information Key Topics Richard Horowitz, MD; Lyme disease; Alzheimer's disease; Alzheimer's biomarkers; Lyme disease and Alzheimer's; Lyme disease and dementia; cognitive decline; neuroinflammation; p-tau217; p-tau181; phosphorylated tau; amyloid beta; amyloid-beta 42/40 ratio; neurofilament light chain; NfL; GFAP; APOE4; Borrelia burgdorferi; chronic Lyme disease; persistent Lyme disease; dapsone; dapsone combination therapy; MSIDS; Multiple Systemic Infectious Disease Syndrome; biofilms; persister bacteria; brain inflammation; memory problems; brain fog; cognitive dysfunction; mold toxicity; mycotoxins; microbiome; infections and Alzheimer's disease; tick-borne disease; Lyme disease research; dementia research; Alzheimer's research.

Send me a messageSocial anxiety and overthinking don't come from what others think—they come from the mental stories we tell ourselves. When we place other people's perceived opinions above our own, perfectionism and anxiety take over.In this podcast, Todd Perelmuter breaks down the root cause of social anxiety and shares how awareness, mindfulness, and presence can stop the overthinking spiral and bring lasting inner peace.Key Takeaways:• Why almost nobody is watching or judging you as harshly as yourself• How resisting anxious thoughts amplifies stress in the body• 2 steps to break free from overthinking and return to the present moment• Why authenticity is the ultimate antidote to social anxietyTimestamps:0:00 - The Root Cause of Social Anxiety1:12 - Why Nobody Is Watching You (The Scooter Story)2:41 - Letting Go of Perfectionism4:47 - Step 1: Catching the Mental Story10:15 - How to Stop Resisting Anxiety15:00 - Step 2: Grounding Yourself in Presence19:11 - Authenticity as the AntidotePlease enjoy other episodes where I share meditation techniques, tips and spiritual lessons from around the world for peaceful and stress-free living. Remember to subscribe to stay up-to-date.Video podcasts are available at https://www.youtube.com/@ToddPerelmuter#SocialAnxiety #Overthinking #Mindfulness #InnerPeace #MentalHealth #PathToPeaceFor the days when life feels like too much, these 4 free books are for you. Get the free 4-books bundleIf my words have ever touched your heart or helped you through a hard moment, I'd be deeply grateful for your support in keeping this podcast alive. Support the PodcastAnd if you'd like to explore these ideas in greater depth, you can find all of my books here.

“What is the sweetest thing in the world?” After co-host Latif Nasser's sons ask him this deceptively simple question, he goes on a quest to find it. Is it a West African Katemfe berry? Or an industrial sugar substitute cooked up in a lab? Or an ingredient hiding in plain sight in all of our pantries? A simple mystery that will make you question what sweetness even is, how our tongues (and other body parts you wouldn't expect) determine what we like, and how far you would go to taste something sweeter than anyone has ever experienced. Thank you to Latif's sons for indulging us, to Nicola Twilley and Cynthia Graber at Gastropod, to Anni Laffitte, Nazli Parvizi at Museum of Food and Drink, to food icons Claire Saffitz and Sam Seneveratne who did a live show version of this episode with us at the Tribeca Festival. And thank you to Davy Gardner and his wonderful team of audio folks at the Tribeca Festival.Thank you to Jialin Deng who composed the song that was our ‘sonic seasoning'. And to Laura Rickman and everyone else at Columbia University's Mortimer B Zuckerman Mind Brain Behavior Institute for hosting us. And big thanks to experimental psychologist Charles Spence at Oxford, sweetness chemist Grant DuBois, Danielle Reed at Monell Chemical Senses Center, and nutritional scientist Sarah Berry at King's College London who all talked to us about their research. And Brian Everett of Honest Organic Farms.And a very special thanks to Sean Oomens, inventor of producer Jess Yung's favorite candy, nerd gummy clustersEPISODE CREDITS: Reported by - Latif Nasserwith help from - Jessica Yung, Maria Paz Gutierrez, Jessica Yung, Ekedi Fausther-Keeys, and Natalia RamirezProduced by - Jessica Yung with help from - Mona Madgavkar, Maria Paz Gutierrez, Gabby Santas, and Maia Appleby Melamedwith mixing help from - Jeremy BloomFact-checking by - Sophie Samieeand Edited by - Pat WaltersEPISODE CITATIONS:Videos:Youtuber Chemiolis tried to make Luguduname himself (https://zpr.io/MmUbGfwwFrFH) Articles -Race to Redesign Sugar (https://zpr.io/VpsMxfPRbxaz) by Nicola TwilleyThe Search for Sweet (https://zpr.io/JmeDkVhrd2dK) by Burkhard BilgerHow My Trip to Quit Sugar Became A Journey Into Hell (https://zpr.io/ni6xgC38Qmyf) by Caity WeverHow Much of Our Existence Do We Owe to Sugar? (https://zpr.io/M2py48SxnQAT) by Jackie Flynn MogensenScientists Find Sugar In Space (https://zpr.io/e94UtUuhPtbT) by Rebecca DzombakSign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)!Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.Leadership support for Radiolab's science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Time blindness isn't laziness or rudeness. It's real, and Chalene Johnson has the brain scan to prove it. She's been chronically late, always has been a struggle, and it turns out there's actual science behind it (ADHD researcher Dr. Russell Barkley calls it temporal myopia). Chalene breaks down why some brains just can't estimate time, including her own scan at the Amen Clinic next to her husband Bret's, and why she missed her flight to Dallas last week. Plus, Patrick Clancy is heading to 60 Minutes this Sunday with his new wife, Rachel, and Chalene gets into why a case like this (or the plastic surgeon on trial in California) can drag on for years. Topics discussed: time blindness, ADHD, temporal myopia, Dr. Russell Barkley, delay aversion, Edmund Sonuga-Barke, Amen Clinic, Bret Johnson, hyperfocus, cognitive dissonance, Lindsay Clancy, Patrick Clancy, Rachel, 60 Minutes, Penelope.   Join Chalene on Patreon her private podcast to listen to the histericous episode "We Have A Mole, Affair Confessions And The Naked Sweat Shop" Go directly to the episode   

Back with another all-time classic. Teal's is one of those episodes I keep going back to because it was just that good. Now more than ever, we need to ask ourselves: what is the role of Ego? Do we need to worry about AI killing us? Is there hope for the future of our species?These are just a few of the big questions you'll tackle in this enlightening and esoteric episode re-run. I'm joined by Teal Swan, a thought leader, bestselling author, and international speaker who is on a mission to reduce human suffering. After a challenging upbringing, Teal emerged with a unique ability to talk about psychology, shadow work, and the nature of our world. Teal shares the unusual and special way she sees the world. We talk about her ESP powers, how to identify a narcissist, and her favorite dimensions. We also get into the divine masculine vs. the divine feminine, the nature of ego, and how to build trust in the world and others. 00:00 — Trailer00:18 — Intro6:12 — Understanding Narcissism13:20 — AI and Spiritual Perception19:30 — Birth Trauma and Memory28:00 — Art and Different Realities35:22 — The Nature of Ego42:50 — Divine Masculine and Feminine50:00 — Hormones and Hope54:05 — Synchronization Workshops1:00:29 — OutroSponsorsButcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighEMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVEResources: • Learn More About Teal's Work At: https://tealswan.com/about-teal/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Wanna hear the FULL Episode? Sign up for the Grad Program today! Welcome to a fun-filled, thrill-packed, soon-to-be-award-winning episode of SOTG Radio. Joining us once more live via satellite from his headquarters in east Texas is Louis Caras of LCAR Concepts. First things first, National Hug Your AK Day is fast approaching. You should order your "RUN AKM" shirt from Faktory47 today, promo code "SOTG". For our tech talk from EOTech Inc. today we will discuss "Hater Tots", the 1 ¾ inch 12 gauge shells and how they might be more useful and practical than you think. Professor Paul breaks down the history of hater tots and the guns that will run them. Have you picked up the brand new book from the Professor, "How, When, What Now? The Brain's Role in Gunfighting"? If not, why not?  Every person who carries a gun for self-defense needs to read that book. Are you bored with your firearms practice? Do you feel that you are no longer being challenged?  Well, Paul and Louis have some serious thoughts on the matter. Perk up your ears and listen a bit louder. TOPICS COVERED THIS EPISODE Huge thanks to our Partners: EOTech | Blackout Coffee Heraclitus 9 + 1 T-shirt from Faktory47 www.faktory47.com EOTech Talk - EOTechInc.com TOPIC: Shotgun Mini Shells: In Defense of 'Hater Tots' www.shootingnewsweekly.com Coffee Corner - studentofthegun.com/blackout [Use Code: STUDT20] TOPIC: How, When, What Now? The Brain's Role in Gunfighting https://amzn.to/3T1pS3d SOTG Homeroom - SOTG University TOPIC: 3 Simple Ways to Make Training Less Boring www.shootingnewsweekly.com

SPONSORS:Remnant House Home GoodsOur friends at Remnant House Home Goods have created beautiful Scripture Sheets designed to surround your children with God's Word from infancy through childhood. Discover Remnant House Home Goods Scripture Sheets and the complete baby gift bundle at: https://shopremnanthouse.com/ And save 10% with promo code: NXRThanks to GoldHaven Resources for sponsoring today's video. You can get their latest presentation here on their website:https://goldhaven-presentation.com/nxr-studiosTickers: CSE: GOH | OTCQB: GHVNFDISCLAIMER: This video was conducted on behalf of GoldHaven Resources Corp, and was funded by PANAM MARKETING.Greska's Carbon 60Carbon 60 is a molecule made up of 60 Carbon atoms, and it works at the root. Chronic inflammation sits underneath almost everything that slows a man down. Sore Muscles. Brain fog. Low energy. and most chronic diseases. And inflammation starts upstream, with oxidative stress at the level of the cell. For faster recovery. Energy that holds all day go to: https://c60.com/ and use code NXR for 20% off your first order. Or call 720 600 6040Right Response MinistriesSupport Right Response Ministries by subscribing to the RRM YouTube channel: https://youtube.com/@RightResponseM or by making a tax-deductible donation by clicking here: https://rightresponseministries.com/donate/ Right Response Ministries is a 501(c)3 non-profit ministry.

Watch every episode ad-free & uncensored on Patreon: https://patreon.com/dannyjones Connor Leahy is an AI researcher & co-founder of EleutherAI. Connor helped expand access to powerful open-source language models, but later became one of the more outspoken voices warning that increasingly capable systems may outstrip society's ability to control them. SPONSORS https://dosedaily.co/danny - Use code DANNY to get 35% off your first subscription. https://livemomentous.com - Use code DANNY for up to 35% off. https://www.amentara.com/go/dj - Use code DJP22 for 22% off your first order. https://hexclad.com/dannyjones - Get 10% off your forever cookware. https://whiterabbitenergy.com/?ref=DJP - Use code DJP for 20% off. EPISODE LINKS https://controlai.org https://x.com/NPCollapse *NEW* DJP MERCH https://dannyjonespodcast.com Get paid to make clips from the show: https://discord.com/invite/dannyjones FOLLOW DANNY JONES https://www.instagram.com/dannyjones https://twitter.com/jonesdanny OUTLINE 00:00 - Anthropic employee's AI warning 04:46 - What AI really is (it's NOT code) 08:41 - The HuggingFace incident 16:33 - The motivation behind the AI race 21:47 - AI superintelligence is our enemy 23:58 - "We don't have much time left": the point of no return 31:41 - AI chain of thought 35:11 - Brain upload cults 43:16 - How AI thinks (and hides things from you) 53:01 - Why AI would kill off humans 57:24 - It's not too late 01:01:23 - Debating American democracy 01:13:44 - Difficulty training AI models for good 01:19:08 - AI translates baby's cries 01:25:28 - Having dinner with Sam Altman 01:31:26 - Why Connor deleted all social media 01:38:09 - We have human cloning technology 01:41:29 - How we stopped nuclear weapons 01:52:08 - Largest human dose of plutonium in history 01:54:40 - UAP sightings at nuclear bases 01:57:16 - "They're not aliens" 02:07:01 - The new alien theory 02:11:42 - Black project researcher: "They suck" 02:15:07 - The push for privatization 02:19:14 - America's political death spiral 02:28:44 - Why Asian countries have no crime 02:35:46 - Most AI employees are cowards Learn more about your ad choices. Visit podcastchoices.com/adchoices

Wanna hear the FULL Episode? Sign up for the Grad Program today! Welcome to a fun-filled, thrill-packed, soon-to-be-award-winning episode of SOTG Radio. Joining us once more live via satellite from his headquarters in east Texas is Louis Caras of LCAR Concepts. First things first, National Hug Your AK Day is fast approaching. You should order your “RUN AKM” shirt from Faktory47 today, promo code “SOTG”. For our tech talk from EOTech Inc. today we will discuss “Hater Tots”, the 1 ¾ inch 12 gauge shells and how they might be more useful and practical than you think. Professor Paul breaks down the history of hater tots and the guns that will run them. Have you picked up the brand new book from the Professor, “How, When, What Now? The Brain's Role in Gunfighting”? If not, why not?  Every person who carries a gun for self-defense needs to read that book. Are you bored with your firearms practice? Do you feel that you are no longer being challenged?  Well, Paul and Louis have some serious thoughts on the matter. Perk up your ears and listen a bit louder.

In this episode of Business Brain, Dave hands ten grand to an AI and gets out of its way. The proceeds from his domain sale became a 90-day experiment: Claude designed a static, formulaic trading system — 60% crypto, 40% equities, running through MCP connectors into Kraken and Alpaca — with lightweight weekly check-ins, a heavyweight strategy review at day 45, and a 48-hour rule that lets the system act if he doesn’t respond. Day 69, up 11%. But the number isn’t the win. The win is an operation where the founder is no longer the bottleneck and the emotion has been engineered out entirely, right down to cutting a 25% loser without waiting for a recovery that may never come. Shannon’s running his own version, parking creator revenue in X Money at 6% until it’s big enough to deploy. Then Shannon walks you through Instinct, a private-beta assistant with no app at all — it lives in your text messages. It read his insurance renewal, caught his son listed as primary driver on a new truck to the tune of $3,118, and drafted the email to his agent. Then it spotted his wife’s girls’ trip on the calendar and had flowers and a charcuterie board on her doorstep by three o’clock Friday. We get into what it costs you to build this yourself versus letting someone else own the infrastructure, and why your job is quietly shifting from doing to conducting. The takeaway: don’t wait for the perfect tool. Start now, learn what genuinely matters to you, and accept that your assistant will miss a few things while it learns you. That’s the charmed life on the other side of a little experimentation. 00:00:00 Business Brain – The Entrepreneurs' Podcast #789 for Casual FridAI, September 18th, 2026 September 18th: National Tradesmen Day 00:01:40 Dave's Barbell AI Investing Update X Money 00:10:04 SPONSOR: SomniPods 3 sleep earbuds from Fitnexa: Flat enough to sleep on, and the app is the real prize: https://go.fitnexa.com/brain automatically applies $10 off (or use code BRAIN). 00:11:37 SPONSOR: Hims. With Wegovy® at Hims, lose up to 20% of your body weight when combined with diet and exercise. Visit https://hims.com/businessbrain to get a personalized, affordable plan that gets you. 00:13:26 Instinct AI, your personal assistant 00:21:43 Business Brain 789 Outtro This Episode's Big Takeway: Train your AI assistant to actually be your assistant Check out Business Brain Blueprints Tell Your Friends! Business Blueprints Review Business Brain Subscribe to the show feedback@businessbrain.show Call/Text: (567) 274-6977 X/Twitter: @ShannonJean & @DaveHamilton, & @BizBrainShow LinkedIn: Shannon Jean, Dave Hamilton, & Business Brain Facebook: Dave Hamilton, Shannon Jean, & Business Brain The post FridAI – Instinct + $10K AI Update – Business Brain 789 appeared first on Business Brain - The Entrepreneurs' Podcast.

Parents have spent years worrying about screens. Now the screen talks back. Dr. Sanjay Gupta asks early child development expert Dr. Dana Suskind what AI may be doing to kids' brains — and why “brain rot” may be the wrong worry.  Resources mentioned in this episode: • Common Sense Media's AI resources for families • The Anxious Generation movement • Dr. Dana Suskind's book, Human Raised  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dr. Michael Leon on Smell Training, Memory, Sleep, Alzheimer's Risk, and Brain Longevity Your sense of smell may reveal more about your brain health than you realize, and stimulating it while you sleep may improve memory, sleep quality, and cognitive function. **Visit https://memoryair.com/ and use code DAVE15 for 15% off. **Host Dave Asprey sits down with Dr. Michael Leon, Professor Emeritus of Neurobiology and Behavior at UC Irvine and one of the world's most cited scientists, to explore why smell may be one of the most overlooked tools for brain health and longevity. Dr. Leon explains why the olfactory system has unusually direct access to the brain's memory and emotional centers, why smell often declines alongside memory after age 60, and why reduced olfactory function has been associated with Alzheimer's disease, cognitive decline, depression, and increased all-cause mortality. They also discuss how COVID, chronic congestion, pollution, stress, and aging can impair smell without people realizing it. The conversation dives into olfactory enrichment, including research showing major improvements in memory when older adults were exposed to multiple scents during sleep. Dr. Leon explains why novelty matters, how nighttime scent exposure may increase deep sleep and reduce nightmares, and why olfactory stimulation is being studied in dementia, PTSD, depression, and autism. Dave also explores connections between smell, GLP-1 drugs, exercise, rapamycin, spermidine, oxytocin, hormones, mitochondrial function, and other longevity interventions. This is essential listening for anyone interested in memory, sleep, Alzheimer's prevention, brain aging, smell training, dementia, PTSD, autism, longevity, neuroplasticity, biohacking, and protecting cognitive function as you age. You'll Learn: -Why your sense of smell often declines alongside memory -How smell connects directly to the brain's memory and emotional centers -Why poor olfactory function is associated with Alzheimer's risk and mortality -How chronic congestion may affect memory and brain health -What COVID-related smell loss may mean for long-term cognitive health -How olfactory enrichment can stimulate memory centers while you sleep -Why one study reported a 226% improvement in memory in healthy older adults -How scent exposure may increase deep sleep and reduce nightmares -Why novelty and rotating scents appear to matter for neuroplasticity -How smell training is being studied in dementia, depression, PTSD, and autism -Why several longevity interventions are also associated with improved olfaction -How GLP-1 drugs may affect smell, food enjoyment, memory, and emotion -Why professional wine tasters may offer clues about protecting the aging brain Thank you to our sponsors! - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.comDAVE and using code DAVE at checkout. - LMNT | Right now, grab any LMNT drink mix and they'll throw in a free sample pack. Go to drinklmnt.com/dave to get yours. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Michael Leon, smell training, olfactory enrichment, sense of smell, memory improvement, brain aging, Alzheimer's disease, dementia, deep sleep, nightmares, PTSD, autism, depression, COVID smell loss, olfactory system, neuroplasticity, MemoryAir, essential oils, cognitive decline, all-cause mortality, GLP-1, rapamycin, spermidine, oxytocin, longevity, brain health, sleep optimization, memory loss, olfactory stimulation Resources: • Visit https://memoryair.com/ and use code DAVE15 for 15% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps: 00:00 — Smell and Your Brain 01:25 — Intro 06:52 — Why Smell Goes Unnoticed 10:59 — Making MemoryAir 15:46 — Smell and Dementia 20:00 — Smell Predicts Lifespan 25:32 — Testing Your Sense of Smell 28:33 — Autism and Olfactory Therapy 36:23 — Biohacking Your Nose 42:50 — GLP-1 and Olfaction 45:55 — PTSD, Nightmares, and Sleep See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Doomscrolling: Alien Abductions, The Goonies, Pinky and The Brain, Pretty Woman, Black Shorties (9/15/26)Doomscrollin is hosted by Sam Tripoli and Midnight Mike.We are back with vengeance!Sam Tripoli's 5th Comedy Special drops Sept 1st on Gas Digital's Youtube Channel: https://www.youtube.com/@GaSDigitalNetworkCheck out Word War Debate 2: https://wordwardebate.com/Please support our sponsors:Quince: Quince focuses on high-quality wardrobe staples made with premium materials like 100% Mongolian cashmere, organic cotton, and merino wool. The styles are timeless, versatile, and designed to become the dependable pieces you reach for day after day.  Find your next fall favorites at Quince. Download the Quince app for app-exclusive offers, or go to Quince dot com slash DOOM. Get free shipping on your order and 365-day returns. Now available in Canada and the UK, too. That's Q-U-I-N-C-E dot com slash DOOM.HIMS: Hims offers convenient access to a range of prescription hair loss treatments with ingredients that work, including chews, oral medication, serums, and sprays.  For simple, online access to personalized and affordable care for Hair Loss, ED, Weight Loss, and more, visit Hims dot com slash DOOMPlease check out Sam Tripoli's 6th Crowd Work Special "Women Can't Peg" Live From Batavia: https://bit.ly/3TZBzHTCheck out WordWarDebate.com for the next great debate event.Grab Tickets To Sam Tripoli's Live Shows At SamTripoli.com:Lawerence, KS: 9/17-9/19Tulsa, OK: 10/9-10/10Austin, TX: Dec 11th-13thWitcha, KS: Dec 18th-19thPlease check out Sam Tripoli's Linktree: https://linktr.ee/samtripoliPlease check out Midnight Mike's Internet:The OBDM Podcast Website: https://ourbigdumbmouth.com/Twitter: https://x.com/obdmpodPlease check out all the Content Creators we featured on today's show:1. Man finds strange object in woods @ninjasarebutterflies2. Ocean predators rip out shark livers @offcialodddanny3. The word to exterminate us all @liveactionorg4. Fake baseball card kid mystery revealed @slabdynastycards5. Sleep paralysis alien experiences strange memories @gregreese6. Suburban living trade-offs near gym good news @hgtvhousehunters7. Pop pop goes the trash can @dungmangmoingay8. Heads missing tribes of lost earth @eerieenigmarealm9. Seeing things that aren't there @the_treehouse_show10. Tattoo story of a mothers unfinished memoir @theartrevival_11. Dennis Nedra never-ending wardrobe quiz @filmbotica12. Silver suits follow a girl with horns @s3anson3dsoulfifty313. Why is the brain recording a frozen pea @treehousedetective14. Mind games Cold War mind control deep state @tayjmcm15. Boston left calf ski viral pop star secret @jonthrifts16. Baffling sounds from a strange box @reasonmagizine17. Not all fairytale creatures live in one book @ellemclemoreshow18. City housing puzzle unlocked @wallstreetjournal @emmacamp19. From oil to cubicles a return scare @n/a20. The seven days of Hollywood hookers @heartthrobanderson21. Popeye cocaine secret set scandal @zingamau22. Real life Soviet research institute movie set @treehousedetective23. Mystery money blooms in desolate lands @dommystories24. pov you're an Asian in the drivers seat of a modern day car @n/a25. How to crack a hot black midget this summer @moggingwbrannt26. Converting got to Israel @porterjugs27. It's not cheating if I'm not sneaking @dareal0828. Neuro deviant @chief_queef_tv29. Missing person - Dixon Myaz @andredavid8830. Kurt & sam talk business @gasdigital31. The daily ‘men suck' scream by @spencerhunt Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Send us Fan MailWhen does a good course stop being fun and start feeling stale? Matt Miller joins Jason to dig into target variety, difficulty, 5-Stand design, practice setups, and the little changes that can keep shooters challenged and coming back. Plus, we've got an update on Neil Chadwick's junior/sub-junior Nationals contest, a Make-a-Break update from Ed, and another trip inside David's Brain. What makes a course great—or drives you crazy? We want to hear from you. Send us your questions, comments, and ideas, and we may tackle them on an upcoming episode.Dead Pair Swag- https://x062jy-1z.myshopify.com. Dead Pair/Kolar raffle- https://e.givesmart.com/events/Pl8/Kolar Arms – https://www.kolararms.com Fiocchi USA –https://www.fiocchiusa.com/?utm_source=the-dead-pair-podcast&utm_medium=bannerGun & Trophy Insurance – https://gunandtrophy.com/                                         Atlas Traps – https://www.atlastraps.comRhino Chokes – https://rhinochokes.comRanger Shooting Eyewear – https://www.reranger.com   Ranger 10% Discount = DEADPAIR10Taconic Distillery – https://www.spirits.taconicdistillery.com/  Discount -DEADPAIR10Long Range – https://www.longrangellc.comMidwayUSA Foundation - https://www.midwayusafoundation.orgSlick Products – https://www.slickproductsusa.com/deadpair     ElJefe Energy – https://www.eljefe.com OtoPro Technologies - https://otoprotechnologies.comBarepelt - https://barepelt.comScore Chaser – https://scorechaser.com/JTECH - https://jtech.digitalMake-a-Break - https://makeabreak.com/                                                           Clay Range Design Works – https://traptowers.coSupport the showThe Dead Pair Podcast - https://thedeadpair.com  FACEBOOK- https://www.facebook.com/Thedeadpair. INSTAGRAM- https://www.instagram.com/thedeadpairpodcast/Patreon - https://www.patreon.com/cw/DeadPairPodcast

HOUR 3 (09/17) - Gary & Shannon hit #WhatsHappening with new Prop 40 polling and a dispute over Princess Diana’s legacy, then #SwampWatch covers the Kennedy Center controversy, growing Canada-EU ties and the latest turns in L.A.’s mayoral race.Plus, what endless short-form video may be doing to our attention spans, and a Hyrox competitor takes “go hard or go home” somewhere it probably never needed to go.See omnystudio.com/listener for privacy information.

The world around us is often filled with noise, uncertainty, and distractions that compete for our attention and energy. When stress becomes constant, it can feel as though our minds are working against us, making it harder to focus, stay calm, and think clearly. John Silva, DC, has spent years helping people better understand the brain and its remarkable ability to adapt, heal, and perform under pressure. By learning how the brain processes stress and responds to challenges, we can begin to work with it rather than against it. Dr. Silva will share how we can harness the power of our brain, even in the midst of chaos, and create greater clarity, resilience, and emotional well-being, with neurofeedback. Now you can listen commercial free at your leisure…Click here and let's grow together: Harnessing the Power of Your Brain Even in the Chaos, John Silva, DC If you love this podcast episode, share it with a friend. The Lillian McDermott Radio Show/Classroom ~ When You Need a Friend… PREMIERE:  Telegram, Facebook, YouTube, WhenYouNeedaFriend.com SUBSCRIBE, LIKE, & FOLLOW:    Facebook, Instagram, X, Website, Odysee, BitChute, YouTube! LISTEN:  Amazon Podcast, Apple Podcasts, YouTube Music, Spotify, Pandora, TuneIn, iHeartRadio! CALL or TEXT: 407-373-5959 “You can take a pill, or You can take Responsibility!” ®

In this episode, I have the pleasure of speaking with Dr. Neil Nathan about the intersection between brain symptoms and complex illness. Dr. Nathan has practiced medicine for over 50 years. He is one of the leading experts in complex chronic illness and mold toxicity — author of the bestselling Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivity, and Chronic Environmental Illness and The Sensitive Patient's Healing Guide. I am grateful to call Dr. Nathan a mentor and colleague. His pioneering work has been responsible for my healing from chronic illness, as well as that of many patients I've treated. Together, we co-lead a small peer group (within the larger mentoring group he provides with Marie Matheson, ND), supporting practitioners who treat those with complex chronic illness.In this episode we discuss:03:43 – Dr. Nathan's path to understanding complex illness11:20 – Why complex illness is rising and underrecognized19:30 – Why new medical ideas take decades to reach patients23:15 – Mold, Lyme, and long-COVID: the “big three” root causes25:58 – The limbic-vagal-mast cell “trifecta”30:31 – Are some people born more vulnerable?44:39 – The risk in “just do limbic retraining” advice47:35 - Biochemical contributors49:26 – Structural root: jaw and cervical instability53:58 – Differentiating Between Mold, Lyme & Long-COVID58:49 – A message of hope, and where to learn moreFull Transcript belowYou can find Dr. Nathan's books, consultations and mentoring program through his website at neilnathanmd.com. If you'd like to help get this information out into the world, please consider liking, sharing, or commenting.Until next time,CourtneyCourtney Snyder MDDr. Courtney Snyder MD is a holistic and functional child and adult psychiatrist and host of the Holistic Psychiatry Podcast and can be found at courtneysnydermd.comMedical DisclaimerThis podcast is for educational purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Consult your own physician for any medical issues you may be having.Full TranscriptDr. Nathan's Path to Understanding Complex Illness03:43Courtney: I'm so glad we're doing this, and I feel like it's long overdue. As you know, in the mental health space in psychiatry, there's a lot of recognition of a dysregulated nervous system, threat response in the body, but oftentimes that's attributed to external forces or trauma, and not necessarily internal threats that we see, obviously, in complex chronic illness, which we'll be talking about. There's also not the recognition of the relationship between physical symptoms and brain-related symptoms. So I know you're going to help us connect a lot of these dots. As we sort of just lay the groundwork for what complex chronic illness is — when in your path did you start to recognize the distinction, when was the beginning of your work and appreciation of complex health issues?Neil: Okay, there are two answers to that question. First, when I went to medical school, my hope was to become a healer. And I was very disappointed that when I got there, I realized they weren't going to teach me to be a healer. And back then I used to question my professors at medical school — why do you do it this way, and how is that? And I kept feeling in all of our interactions that we were missing something. And my professors would go, “Okay, Mr. Wise Guy, smart guy, what are we missing?” And I'd go, “I don't know, I just know we're missing something.” Later I would come to recognize that we were missing the emotional and spiritual component to whatever was affecting people in their illnesses. And I have language for it now — I didn't then. The person in medical school who influenced me the most was Elisabeth Kübler-Ross, who I view as my main mentor in medical school. She, unlike anyone else, had a one-and-a-half-hour seminar once a week. Back then there weren't video cameras — you were in a small confined room with a two-way mirror, and you're sitting there watching someone do this. And she would simply interview one of her patients. She was a psychiatrist, but she was the only one in medical school who demonstrated how to really listen to people, how to really communicate with them, and not have this standard review of systems — here's my questions, here's your answers, and that's what I do, and this is what I write up. She was really listening. She was trying to really take in, okay, what happened to you, and what's going on with you? So I would want to give her credit as a role model to change how I learn to listen. Okay, that was step one.I'm going to fast forward to the early 1980s. And I am, at that point, the medical director of a regional pain clinic. And we are starting to see a whole bunch of patients who had this complicated process of fatigue, unrefreshed sleep, irritable bowel syndrome, and pain migrating all over their body. And back then we called it fibrositis. Now we call this fibromyalgia. And so whenever medicine encounters a thing that they don't know what they're looking at, it's psychological until proven otherwise. And people would get therapy, and they would take antidepressants and anti-anxiety agents. Didn't help much. And so it became clear to me that we didn't understand what this was at all. It was not psychological. Something was going on in their bodies — now I recognize it as an inflammatory process. Back then there was no concept of that at all. And then, slowly, in the early nineties, we began to find pieces of the puzzle to understand what was triggering fibromyalgia. I was working back then with Jacob Teitelbaum, who did a lot of work with chronic fatigue and fibromyalgia, and we both independently came up with an understanding that a deficiency of magnesium, DHEA, adrenal issues, thyroid issues, sex hormone deficiencies, GI dysbiosis, and food allergy — if we looked at those and treated those, the majority of people with fibromyalgia got cured. It was different for different patients. It was not like there was one thing that caused it. And as time evolved, we began to realize that there was lots of other biochemical imbalances in the body that would contribute to this kind of a process that represented chronic fatigue and fibromyalgia.We discovered that Lyme disease and coinfections was a huge piece of that. And later still we discovered that mold toxicity was a huge piece of that. And so my understanding of the complexity — and it's not really confined to chronic fatigue and fibromyalgia at this point, we're really talking about almost all chronic illness — with a huge psychological component to that. So we've begun to understand this as essentially some version of inflammation. And if we start to really dig into what are the potential causes of that inflammation, we can make a huge impact for them. So this is a multi-year evolving understanding of how a person's genetics, biochemistry, physiology impacts their whole being in every way. And that inflammation extends to the nervous system, contributing greatly, if not causing directly, a large number of what are now called psychiatric diagnoses.Courtney: Right. So even among those patients that you were seeing — you were seeing, I'm assuming, depression, anxiety, brain fog?Neil: Yeah, the vast majority of our patients with mold toxicity have brain fog and anxiety, depression, OCD behaviors, mood swings, depersonalization, derealization. I mean, all of that is super common in our patients.Complex Illness Is Rising — and Underrecognized11:20Courtney: Do you feel like this is more recognized now — or do you feel like the number of people being hit with these complex health issues is increasing — or both?Neil: Both. I would love to say that the medical profession is increasingly recognizing all of this as important, but that recognition is coming very, very slowly. The majority of folks out there, if they were to list the symptoms that they had, their doctors would basically look at them like, “I have no idea what's causing it, so this must be in your head.” And that is the message they're getting from their physicians at this point. So many patients are being gaslighted, so many patients are being told it's in your head. And the repercussions of that are the family is hearing that same message, and the families become less supportive of those people, because they're saying, “This is not real, so why would I support you? This is still in your head, go get your head fixed.” And they're wrong, and it's really a travesty. But so yes, very slowly, this awareness is growing. There are now more medical meetings that I'm aware of where psychiatrists can learn more about this than there were ten, fifteen years ago, for sure. But not enough — it's still not enough.The other part of that is some of the main triggers for this inflammatory process are increasing. So we're seeing more and more mold toxicity, we're seeing more and more Lyme and coinfections, partly because the environment that we are all exposed to has gotten extremely increasingly toxic. So it's now known, for example, that there are 350,000 new chemicals in our environment than existed 70 years ago. The vast majority of those have never been tested for safety in human beings. So human beings have a tremendous amount of chemical exposure that they never had before. Human beings have a tremendous amount of EMF, electromagnetic exposures that they never had before in the history of the human race. So these exposures are cumulative. Our major organs, like our liver and our kidney, that have to deal with toxicity, are overloaded. And so, yes, we are seeing an epidemic of a whole bunch of these conditions. In children, we are aware that autism has skyrocketed — it went from one in several thousand kids to one in thirty kids in many states now have autism. And forgive me, but the pediatric profession is not taking this seriously. It's like, “Yeah, that's sad, it's unfortunate.” It's like — really, you don't want to look at this? This means one in every three kids born are getting autism — does that not concern you? But, forgive me, the medical profession is very slow to embrace new information, and that is really to the detriment.We're seeing an epidemic of Alzheimer's, Parkinson's, ALS, all of which involve neuroinflammation. We've seen already an epidemic of chronic fatigue and fibromyalgia. And all of these things are interrelated, because — yes, I'm supposed to be an expert on mold toxicity, and I probably am — but mold toxicity doesn't exist in a vacuum. You have mold toxicity as one of multiple environmental toxins we're being exposed to. It is simply one of the most common, the easiest one to diagnose, because we have tests for it. We don't have tests for the hundreds of thousands of chemicals out there. We're just beginning to be able to have some tests that will tell us what's in someone's body that might be making them sick.Courtney: Right, right. And I would imagine that this typical medical model of looking for one cause to autism, one cause to dementia — it's a completely different way of thinking. When you get away from that and you look at complexity of the human body, that way of thinking holds back the research, it holds back any progress.Neil: What I think is helpful for people to look at is: we are all uniquely, biochemically, genetically different. And so the same inflammation in one person could trigger cardiovascular disease, and another person could trigger Alzheimer's, and another person could trigger chronic fatigue. So we need to take a step back and go, okay — and this is not a brand new idea. For the last ten years, there are many papers in the medical journals that are saying chronic illness is almost certainly an inflammatory process. Now, it hasn't really integrated into what people are being taught in medical school or in their residency program. But this is not a brand new idea, and there's tons of medical research documenting that.What behooves us as physicians is to look at every human being and go, “Okay, this is your named chronic condition — what are the triggers for you?” We have to kind of be like a medical detective and dig in and go, okay, what's triggering your inflammation, so I can treat the cause — not put a band-aid on it, which is, forgive me, in the psychiatric field, taking antidepressants and benzodiazepines. That's a band-aid. It's a helpful band-aid, it could be a very important band-aid, help someone to function. But you really need to be looking at, okay, I have this great band-aid, but wouldn't it be nice to actually cure this? And I think that would be, for me, to your audience, Courtney, my take-home message — which is always look for the root cause, because it is possible that we will find that root cause, and you won't have whatever name you've been given, depression, anxiety, OCD, for the rest of your earthly life. Maybe.And I've treated thousands of people successfully here. So this is not — I've had one or two successes here — we're talking thousands of people that have responded to this way of practicing medicine, with fabulous results. People who've been literally bedridden, incapacitated by their illness, are now out there working again and being with their family and living full lives. So that's the take-home message.Courtney: Right. Which makes it so satisfying to treat. And I mean, I can speak to that, having experienced it personally. But at the same time, you do get pushback from other areas of medicine that don't give it necessarily credibility, even though people, on the other side, are thriving and healing, and it's really amazing.New Medical Ideas & Research Take Decades to Reach Patients19:30Neil: You know, the history of all science, including medicine, is: new technology, new drugs are fast-tracked to get into our lives. Ideas, not so much. Typically it takes a generation — twenty, twenty-five years — for a new idea to come into acceptance. And the first reaction of any science, medicine included, is to get into denial, which is, “There isn't enough data to support this concept, and I can't be perceived as practicing bad medicine by embracing a concept that isn't proven yet.” But that means that all of their patients are going to have to wait twenty years — until suffering — until that person goes, “Now there's enough evidence, now I can learn how to do this, and now I'll begin to help you.” I'm not wired that way. I'm wired that if I have a suffering person, and I have something that I can offer them that might help, I'm going to try it. I'm going to do it in the safest way I know how, but I can't leave someone dangling for twenty years and say, “I'm sorry, I have to wait until my profession figures out what to do.” That's not me.I worked at the medical school at the University of Minnesota Duluth for eleven years. And I was not only on the faculty, but I was on the committee that determined what new information was put into the curriculum. For example, AIDS was just coming into vogue at that particular point, and it was obvious that we needed to have courses on AIDS for the medical students, because this was big. What a lot of people wouldn't understand is that each department in a medical school fiercely guards its time allotment. Everyone gets a certain number of hours, and they're not open to adding new things or giving up any of their time slots for anything new. And so what I would watch is, as new information came into the medical school, each department fiercely refused to add any new lectures in their department, or give up any of the time that they had to anybody else to add that information. So we're talking about university politics now — this is not even medicine, this is people guarding their turf. And I don't even think that would occur to any consumers, that that would happen like that — well, certainly, why would that happen in a medical school? Well, it's because human beings are responsible for each department, and they guard their own turf. So it's a kind of an insidious process about how new information isn't embraced by the profession, to go into the medical school curriculum.Mold, Lyme, and Long-COVID: The “Big Three”23:15Courtney: I want to come back to what you were saying about inflammation being at the core of chronic illness and complex chronic illness. And when it comes to complex chronic illness, whether it's SIRS or mast cell activation from mold or Lyme, we talk about multiple systems being affected — the central nervous system, gastrointestinal tract, endocrine, skin, just you name it. If the inflammation then is from a source of oxidative stress or a major insult — would you say that mold toxicity is the most common, or would you put Lyme or now even COVID on a par with that, as far as the deepest roots causing the inflammation? Not that the chemicals, metals, and everything else we're being exposed to aren't at play.Neil: In my experience, those three are the biggies — mold toxicity, Lyme with its co-infections, and long-haul COVID. Those are the three most common. Of those, in my experience, mold is the most common, and the one that has to be treated first if you have some or all of them. So, for example, in people who have long-haul COVID or Lyme, often their body will not respond to that treatment optimally until you first get the mold out. So there's a little hierarchy of what we do, in what order. And then within that hierarchy, there's also an order in which we do things for people to respond optimally. So, for example, mold toxicity will trigger — and Lyme and Bartonella will do the same thing — limbic dysfunction, vagal nerve dysfunction, and mast cell activation in most of our patients. Not all, but in most. And the longer they have it, the more likely those things are going to get triggered. Once somebody does not feel safe — and the systems that we have in our body to monitor that safety and to keep us safe are the limbic system, the vagal system, and mast cell activation — we have to get the body safer, or it will not be able to take what you need to take to treat mold or Lyme or long-haul COVID. People will literally shut down — their limbic system will essentially go, “Mm, I see what you're trying to do there, and I can't let you do it, because I'm not sure that's safe.” And it will literally not allow people to do it.The Limbic-Vagal-Mast Cell “Trifecta”25:58Courtney: So with one of those, or a combination of those, on board, these threat mechanisms would be kicked up — mast cell activation, limbic system dysfunction, autonomic nervous system dysfunction. If they look similar, or a timeline isn't easily helping parse out what might be primary, how able do you feel to make the distinction — versus if mold is present, starting there?Neil: If we look at our patient's symptoms, they will point us clearly to whether there's a limbic or vagal or mast cell piece, to be specific. The limbic system's job involves primarily monitoring and regulating and keeping emotion and sensitivity in check. So any symptoms that involve those two things are limbic almost by definition. So on the sensitivity side, if someone describes an increased sensitivity to light, sound, touch, smell, chemicals, EMFs, food — they're already telling me my limbic system is dysfunctional. In some ways it doesn't matter what the cause is; if someone has this increased sensitivity, regardless of the cause, I know we have to treat their limbic system first.On the vagal side, the symptoms would primarily run into symptoms that involve the autonomic nervous system, which would involve things like temperature dysregulation, palpitations, insomnia, POTS, blood pressure dysregulation, or symptoms that involve the gastrointestinal tract, because the vagus nerve controls almost the entire intestinal tract. So any GI symptoms — gas, bloating, distension, reflux, diarrhea, constipation, abdominal pain — again, that would lead me to go, the vagus is involved here. So by listening to my patient's symptoms, I can immediately know what's dysregulated here, and what my first treatment arm will be — to get the limbic and vagal systems back up and running again at a safer level, because otherwise our patients aren't going anywhere. They can do binders and antifungals and antibiotics for Lyme, and they will get worse. Their body will basically go, “I know I might need that, but why are you doing that? I can't even get to a place of safety to respond. I'm on self-preservation mode here.”And in the mast cell category — again, all of the same symptoms that could be mold or Lyme or long-haul COVID could also be mast cell. Again, it's a multi-systemic process. A tip-off, which I find very helpful, is if someone describes a symptom that comes on immediately after eating, sometimes while eating. Nothing causes that kind of reaction that fast except mast cell activation. Allergy — and most people, if they do have some symptom that comes after eating, they're going to be thinking, “It must be what I ate, what did I just eat?” But it's not food allergy, it's mast cell activation. In that context, many of our patients have already observed that they can eat a particular food one day and have a very strong reaction, and the next day, same food, nothing. And they'll go, “That doesn't make sense — if this was allergy, I ought to react the same way every time.” And so that is classical mast cell activation, which fluctuates. So — for the first part of your question — that's what I'm looking for. When I take a history, when I talk with patients, I'm going to really dig into: are they already manifesting symptoms that clearly tell me what we need to do first, to get them safer, so that now they can respond properly to the treatment that will really get at their root cause.Are Some People Born More Vulnerable?30:31Courtney: I know you take deep timelines when you meet with someone, so you're really accounting for a lot. But one of the things that I think about a lot is: who is most vulnerable? Do some of us come into the world already with a vulnerability similar to Elaine Aron's highly sensitive person model? And then maybe there's trauma, early attachment disruption — and already vulnerabilities — but then the toxic load that we're all experiencing. But then something like mold or Lyme then hits. And then, all the years and all the patients you've seen — I'm curious how many you feel already had sort of a vulnerability. Not that they ever had to really become sick necessarily, but already had a vulnerability.Neil: Honestly, I would say most. Our limbic system evolves from the time we were in our mother's uterus, so that almost no one has had a perfect childhood. And so whatever someone has had to deal with in childhood — it could be recurrent ear infections or throat infections, or it could be a surgical procedure, or it could be parents, both of whom worked and they didn't get enough time, or they could be abusive parents, sexually, physically, verbally abusive — whatever someone has been exposed to, that forces their limbic system to have to deal with it. Because that's the job of the limbic system, is to keep you safe. So your limbic system is basically going, “Okay, I'm just a little thing here, what do I need to do to cope with this?” And so their limbic system slowly, inexorably, becomes more and more hypervigilant to protect them. Let's say someone had an alcoholic parent, and they would come home, and you were never sure what their status would be — and so you'd kind of hold yourself back from that, which is, “I've got to see what this person is showing me, is it safe for me to come up and give them a hug, or do I want to hang out in my room for a bit until whatever this is settles down?” That's the beginning of this limbic hypervigilance process. And then it just goes on through life. So that if you've had difficult relationships, or surgeries, or severe infections, or anything in the physical or emotional or spiritual plane, a betrayal of some type — the limbic system becomes slowly more and more and more hypervigilant, when the straw hits the camel's back. And that straw could be COVID, or Lyme, or mold toxicity, or another infection of some type — that's the straw that breaks the camel's back. At that point the limbic system goes into shutdown, which — we know the vagal system goes into shutdown, literally, that's something the vagal system is trained to do. It's “okay, we are so unsafe that I'm shutting down my systems here.” And so that predisposes to illness. But I want to tie that back to inflammation, which — a lot of people don't understand that the vagus nerve, for example, controls inflammation in the body also. There are branches of the vagus that go to the spleen, to the gut-associated lymphoid tissue, and to the thymus, all of which are major immune organs. And if the vagus is dysfunctional, inflammation can rage out of control. So again, this comes back to understanding this complexity of inflammation, and how we need to both understand it and know where it is we want to look to get at that inflammation. So there is a profound interconnected limbic-vagal-mast cell piece. Each totally connects to the other. There's an interaction between the thousand biochemical mediators that mast cells make and the nervous system itself. So I call this interconnection the trifecta, which is: you can't just treat the limbic system in a vacuum, because if you're not also looking at the vagal and mast cell system, your treatment may be a little bit helpful, or it might not even work at all, until you combine all three — so that you really understand this is a package deal here, in terms of how we work with it.There was one more piece I wanted to add, Courtney, to understanding the inflammation piece: whether or not someone gets mold toxicity or Lyme or COVID depends on how robust their immune system is. So you could have a family living in a moldy environment — one person is really sick, several are a little bit sick, and one is not sick at all. And the one who's not sick at all can easily go, “I'm not sure what's wrong with you all, but I'm fine in this environment, it can't be my environment because I'm fine.” And what they're not understanding is: yes, they are fine, as long as their immune system stays robust. For the others, they were at risk for all of these conditions because their immune system took a hit. And for many people who were living in a moldy environment, during COVID, for example, when we isolated and people were spending twenty-four hours in their home rather than the eight hours out, they were many now being exposed to more mold at home than they were before. I don't think people began to think about that or look at that. So in that environment, whether or not they were affected depends on the hit they took. Now, the things that will hit an immune system to weaken it, and allow whatever's there to manifest, are: COVID was a biggie, any severe infection, a surgical procedure, childbirth, menopause, or any emotional upheaval will weaken that immune system, and then the immune system loses containment, and now we are off to the races. So what I try to convince people who are living in a moldy environment who are well is that they're living with a ticking time bomb. Should they take an immune hit, they will be just as sick as their family member who they're kind of lording it over, which is, “I'm not sick, what's wrong with you?” You'll be right there yourself if you take that hit — to try to help them understand, yeah, you're okay for now, but once your immune system weakens. So I'm trying to tie together the immune system, its ability to regulate inflammation, and this whole process here.Courtney: Right, right. Which I guess is why we call it complex, complex illness.Neil: It is the way human beings are. We're not making up a new word of complex illness — illness was always complex. We're just beginning to understand how complex it always has been.The Limits of Treating Symptoms Alone44:39Courtney: Right, so there's communities out there addressing mast cell activation. There's communities out there addressing POTS and dysautonomia. Communities out there addressing OCD and more obvious limbic-type issues. And then there's the whole mental health field. And the dots aren't getting connected. I mean, I've yet to see someone with OCD — I think it's like eighty to ninety-five percent have mold toxicity as part of the picture.Neil: You know, an example — and I won't name names — is there's an eminent pediatric physician who is very well known for his work in autism, who thought he was ADD his whole life until he recognized that he had mold toxicity and started taking antifungals, and all of a sudden his brain went online and he doesn't have it anymore. So that's just a very clear example of what you're talking about. And what we are talking about is: it's absolutely essential that all people who work in the medical field, all healthcare providers, embrace this complexity, because if you're only working on a piece of it, you will help some people to a certain extent, but you will not help people optimally. I mean, that is the absolute bottom line.The understanding that mast cell activation was huge came in 2016, when Larry Afrin wrote his book, Never Bet Against Occam. It was a huge game changer. When I read his book, it was like, “My goodness, I've been missing this in my patients.” And the whole world embraced this information, so that every medical center in the country now has a mast cell activation clinic. However, they're looking at it as a single thing with a label to it, and they're treating it just that way. They have not recognized that if they don't add limbic and vagal work to it, their treatment is not going to be adequate. And so, yes, they're helping people, but absolutely not optimally. And to make it worse, very few of those clinics have recognized that what's causing mast cell activation, which absolutely needs to be treated, is mold toxicity and Lyme. So people go to these clinics and get a certain amount of help, but they're not being treated comprehensively, which is a pet peeve of mine — which is, come on, if you're going to have a clinic, understand the whole interactions of whatever name it is you're working with. If you're going to be an ENT specialist, understand everything that impacts that area. If you're going to be a cardiologist, understand everything that impacts it. And we just don't see that. We see people kind of in their little box — “No, no, I've learned this, this is what I do, this is how I work” — and it's just unfortunate that they're not looking at the bigger picture.Courtney: Right, I think add to that PANS and PANDAS, because in psychiatry, people feel like they're deep diving because they're getting to PANS and PANDAS. It's like, okay, you've got to go deeper than that, because even those conferences, they talk about the need for treating relapse, and it's just going to keep reoccurring.Neil: I mean, they're using IVIG to help. That's nice, but they're not getting to cause. And we know when PANS and PANDAS first emerged on the scene, it was all about strep, and that was the focus for a long time. But as time emerged, it was very clear that this was a neurological inflammation triggered — here we go, broken record — Lyme, mold, other infectious agents had to be looked for. And if we treated those, you could cure PANS. It wasn't something that needed IVIG for the rest of your earthly life.Courtney: Even among those, would you say very often mold is underlying the mycoplasma, the candida?Neil: I think mold is one of the most missed components to illness that I can think of. If I have a goal in life, it would be to raise the consciousness of our profession as to the importance of mold toxicity, how common it is. We're talking millions and millions of people who are not diagnosed, because their doctors don't know about it, and therefore are not making the diagnosis. I'd love to see the consciousness get to the point that someone would present with these complicated stories and a doctor would say, “Why don't we think about mold toxicity?” That would be the most important thing I would have done in my career.Courtney: Yeah, well, you're certainly raising awareness.Neil: I'm working — it is slow. As we said, I'm working on a twenty-year generational issue here.Courtney: You've mentioned that the underlying source needs to be addressed, but the nervous system and immune systems need to be addressed. So one of the things that comes up with limbic system retraining is: I've had people hear the message that if they just address their limbic and autonomic nervous system, then they wouldn't need to address what I see as an ongoing threat, such as a mold toxin. So I'm hoping you can speak to that, and the importance of these programs, despite that.Neil: Sure. A couple of the better-known limbic retraining programs, the coaches get a little bit zealous about — “limbic retraining is so important, this is all you need to do alone, don't even do anything else, just do limbic retraining.” And I suspect that there are a handful, very few, but a handful of people who've gotten well just doing limbic retraining. If, for example, if you had mold toxicity, if it was relatively new, if you had not colonized, and you moved out of your mold exposure soon, it is possible that the limbic retraining would help reboot it to the point that your immune system rebooted itself and you'd be fine. I believe there are a few people like that. The vast majority of people who have limbic dysfunction — you need to do limbic retraining and vagal retraining. You may also need to do mast cell retraining, and please look for the cause of that. Those are downstream effects, those are not named diagnoses that you treat alone and it fixes it. Please look for at least mold and Lyme, which are the two most common things that are triggering this at this point. And people are getting the wrong message if they think they need to do it in a vacuum. To make it worse, they're being told, “No, no, just do limbic retraining, that's all you need.” And the truth is, no, you need to combine limbic retraining and vagal rebooting and mast cell activation most of the time. And of course you've got to get back to cause.Courtney: Right, I mean I try to liken it to — if they were in an abusive relationship or toxic relationship, they wouldn't just limbic-system their way out of that, if there was an external threat.Biochemical Contributors47:35Neil: No, you've got to fix what's primary here. I want to add to this discussion — we're focusing on inflammation from toxins and infections, but there are also other biochemical issues, some of them downstream, that need to be looked for and addressed in order for people to recover completely. So, for example, Lyme and mold will trigger kryptopyrrole issues, or imbalances in the ratio between zinc and copper, or they'll trigger methylation issues super commonly. And I just wanted to expand this discussion — I know it's complicated enough, but I don't want to oversimplify it either — that there are other biochemical things that we want to be looking for, because they're treatable, and they will help people to heal faster, if we're also addressing methylation, the need for zinc, the need for magnesium or B6 — those are common components of this whole process here. And so I just want to kind of tie that all together for a moment.Courtney: No, I'm glad you did, because those are topics that I talk about here, so it's important to connect those. The other thing I see, because I integrate the Walsh approaches with treating people that have complex health issues, is zinc seems so amazing when it comes to mast cell activation — making sure that's optimized. As well as connective tissue — and that was something else I wanted to ask you about — is structural issues that can be impacting the autonomic nervous system. I just see a lot of people — I inquire about it because I had it myself — but who have upper cervical instability as part of this whole picture.Structural Contributors49:26Neil: Again, all of these things are interrelated, and the physical structure can prevent people from moving forward in several different ways. One is the structure of the jaw and the face — the body puts a priority on teeth occluding properly. And if the teeth don't meet just quite right, and the jaw is a little bit out of structure, people often talk about TMJ — the body basically freaks out, it goes into sympathetic overdrive. And for some patients — it's not common, but I've seen several dozen — where the jaw had to be realigned by a combination of dentists specially trained in this work, working with osteopathic physicians, to realign the jaw. Often in those patients, they couldn't respond to the limbic and vagal treatment until their jaw got realigned.Same thing is true with what you're talking about, as cervical cranial instability, which is basically a weakening of the ligaments at the base of the skull, where it attaches to the first cervical vertebra. Now, these are all again intertwined — for example, it begs the question of what weakens those ligaments. And the answer is: if you have mast cell activation, some of the materials that the mast cell makes weakens the ligaments. So the ligaments get weak, and where the skull attaches to the first cervical vertebra, instead of being pulled apart, like ligaments do, it collapses. And that influences the blood flow to the brain, the nerve flow to the brain. And again, the body recognizes that as a priority, and often you can't get that better — you can't get limbic and vagal response until that gets fixed.So there are a bunch of structural issues that also need to be looked at, when people become overly sensitive and are not responding properly. And there's more in that area. So, for example, there's a chapter by Tasha Turzo, who's an expert on the jaw structure. There's a chapter in there by Andy Maxwell on cervical cranial instability. So that book would give people a really good overview of how complicated things are, and they might, chapter by chapter, get a clue of, “I haven't looked at this piece yet.” I mean, we haven't talked about oxalate or salicylate imbalances, which can add to that. So I just think that is a resource for folks that could really help them understand how they've gotten where they are, and understand the path out.Courtney: Right, right, because not everyone has all of these areas, but certainly could be held back or have a unique something that they could be getting relief from early on in the process. So I think it's both, to the degree that people are able to learn, and your book Toxic, too — it's like an encyclopedia, even if someone doesn't read straight through it, they can go to the mast cell section, or they can go to the Bartonella section.Neil: It was intended to be a readable way to understand this complexity, because it basically will talk about almost everything we've talked about today, and help people to get better understanding. I mean, we've talked about the bigger picture today. We didn't talk about, okay, how do you diagnose Lyme, how do you diagnose mold toxicity, how do you diagnose long-haul COVID, and most important, because this is very complicated, how do you decide which of those is the biggest player that you want to address first?Distinguishing Between Mold, Lyme & Long-COVID53:58Courtney: Right, I have shared resources on diagnosing mold toxicity. Would you comment on your last point — how do you recognize, are you using specific testing that you want to reference, the RealTime?Neil: I do. But I would emphasize, we're taught in medical school that if you really listen to patients, ninety-five percent of the time you will make the diagnosis by history alone. And I don't want to get too focused on testing, because listening to the patient and having them describe in detail what they're going through will really give you the little pieces you need to tease it apart to a certain degree. That's only possible to a certain degree, because there's a huge overlap between the symptoms of Lyme and Bartonella and mold and long-haul COVID and mast cell activation. Huge overlap. So there's little teeny pieces that will tend to lean more in one way than another. And honestly, that's what's required from all of us, literally years of study, to really get a handle on — someone will say something, okay, that's much more of a mold symptom than it is a Lyme symptom, something else. So I do encourage people, if they think they might have mold, to get a urine mycotoxin test. That has revolutionized our ability to make these diagnoses.Courtney: Would you still set RealTime as the preferred? That's what I've communicated to this audience.Neil: I would. Any test can help make the diagnosis, but for follow-up testing, the only one that's been really consistent is RealTime. And you want a follow-up test, so you want to know what your baseline starting is, and then you want to know, okay, am I getting these toxins out of my body? From my perspective, you know that you're done treating it when that RealTime comes back reading not present in every category. We have better tests now for Lyme than we've had in the past. Years ago, our tests were inadequate to say the least. And the CDC recognized years ago that the tests were so inadequate that it was basically a diagnosis made by a physician by examining all of the history and information that you had. That was enough — you didn't need a lab report to make the diagnosis of Lyme disease. A new test that I'm particularly fond of is Bruce Patterson's fourteen-panel cytokine test. This is a test that measures cytokines, which are the molecules of inflammation — cytokines are made by your immune system to deal with, or fight, different inflammational causes. And so what Dr. Patterson has discovered is there's a pattern of cytokines that we see with long-haul COVID, which is different than the pattern we see for Lyme. And I'm working with him now on the pattern for mold. So we can literally look at that test and look at, okay, what is inflaming this person primarily now, because I'm looking at that inflammational pattern, and I can literally read that. Some of my patients will have all of those on a particular test, or only one, but it really helps tease apart what is — I call it public enemy number one for my patient, what do I need to address as root cause right now. So our science is improving as we go here.A Message of Hope — and Where to Learn More58:49Courtney: And that's huge. Before we go — I think all of your books, but I'm thinking specifically about Toxic and The Sensitive Patient — all the information you generously share gives people a lot of hope who've been struggling out there. And I think your mentoring and teaching so many of us helps extend some of that reach. Is there anything you'd want to convey to people out there in the throes of chronic illness who are feeling hopeless and not getting the feedback from their doctors that this is something they can get beyond?Neil: Sure. My take-home message is always: everything we talked about today is treatable. Is there hope in there? You bet there is. But if you are not getting the help you need from whoever you are seeing, find someone who understands these things. For example, I do have on my website a list of physicians that I've trained over the years that I'm comfortable that they really know what they're doing — it's a growing list. There's someone like Courtney, who's been trained for years to do this, she's good at it. Find someone who knows what they're talking about, so that you can get someone who does embrace this complexity, and will look at it in its entirety, and then get you moving in the right direction, doing the right things in the right order. To me, this can be done. I mean, I have personally helped to cure four or five thousand people with mold toxicity, and an equal number of people with Lyme disease. So we can help the vast majority of people that we're seeing. So, regardless of how long you've been sick, if you haven't been properly diagnosed and you haven't gotten the right treatment, you can be helped.Courtney: Right, right, that's great. And for physicians out there who are interested in learning more about complex chronic illness — are there resources you would point to? I'll be sharing your books, because I think those are great references — but also how people can find what you're doing currently.Neil: Sure, my books — particularly with this discussion, Toxic and The Sensitive Patient's Healing Guide would be the two most appropriate. I would add that I have just finished writing a book on this whole subject of inflammation. It's currently being edited, I hope it'll be out by early next year. So if you stay tuned to my website, I'll let people know when that's going to be available. And I think, Courtney, what you're referring to is: I do have a mentorship program for healthcare providers. We now have three hundred and fifty-plus people in the mentorship program, it keeps growing. You were in one of the first groups — we started with eight, and then people kept wanting to get in on it. So we welcome people to join. If you go to my website, which is simply neilnathanmd.com, there's a whole thing which talks about the mentorship and how to sign up for it. So I certainly welcome people who want to learn more.Courtney: And then you offer consultations and professional consultations also?Neil: I do. My consultations — I am, at this point, since I'm semi-retired, not seeing people directly. But I do offer consultations with a patient and their primary treating physician — so we all get on a Zoom together, and we will go over the details of that person's history and their lab work, and I will help outline a treatment program that looks to me like it will get people well. And actually, Courtney, I actually do a lot of that — I'm not really retired, my wife will tell you. I stay pretty busy. I love helping people. I love being able to take this complicated information and tease it apart, so that I can help people to understand what they need to do, in what order, in order to get better.Courtney: And we're all grateful — grateful that you've followed your path, because so many people have benefited personally and professionally. So thank you for bringing your wisdom and expertise, really appreciate it.Neil: You're very welcome, happy to do that.You can find Dr. Nathan's information, consultations, and mentoring program through his website at neilnathanmd.com. If you'd like to help get this information out into the world, please consider liking, sharing, or commenting.Until next time,CourtneyCourtney Snyder MDDr. Courtney Snyder MD is a holistic, functional, and environmental psychiatrist for children and adults. Find her at courtneysnydermd.com and on the Holistic Psychiatry Podcast on all major platforms.Medical DisclaimerThis podcast is for educational purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Consult your own physician for any medical issues you may be having. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com

What Is Consciousness? Near-Death Experiences, Neuroscience, Frequency & Exploring What Lies Beyond the Brain | MasatiWhat exactly is consciousness, and is it something that exists beyond the physical brain?In this episode of Psynautical, I sit down with Masati for a fascinating conversation exploring consciousness, near-death experiences, neuroscience, frequency, Xponential Intelligence, and our understanding of reality.Masati has experienced multiple near-death experiences that he says profoundly changed his understanding of consciousness, human potential, time, space, and the nature of reality. His experiences eventually led him to develop what he calls Xponential Intelligence (XI), a framework centered around consciousness, frequencies, and human transformation.We dive into what happened during his near-death experiences and how those experiences influenced the way he sees consciousness. We also explore the relationship between science and spirituality, including where concepts such as neuroscience, quantum physics, frequency, and what Masati describes as our personal “blueprint” intersect.But rather than simply accepting extraordinary claims at face value, we also discuss the importance of questioning, skepticism, and trying to understand these experiences through different perspectives.In this conversation, we explore:• What consciousness actually is and whether it is limited to the brain• Masati's multiple near-death experiences and how they changed his perspective• What he experienced during those encounters with death• The relationship between near-death experiences and expanded consciousness• How neuroscience may help us understand consciousness and subjective experience• Xponential Intelligence and the ideas behind it• Frequency, energy, and Masati's concept of our personal blueprint• The relationship between consciousness, time, and space• Science, spirituality, and where the two may intersect• How to remain curious and open-minded while still asking difficult questions• Whether extraordinary experiences can teach us something about human potential• Practical ways we can become more conscious and aware in our everyday livesWhether you're interested in near-death experiences, consciousness, neuroscience, spirituality, or simply the deeper questions surrounding what it means to be human, this conversation offers plenty to think about.Connect with Masati and learn more about his work:

Why do we procrastinate, even when we know it's holding us back? Brain Lady Julie dives into the science and psychology of procrastination and explores how the brain prioritizes immediate comfort over future rewards. Learn why procrastination isn't just laziness, what's happening behind the scenes in your mind, and practical strategies you can use to overcome it and take action with confidence!Julie's contributed book mentioned in the showConnect with Brain Lady JulieDo you have a great question or topic you'd like Brain Lady Julie to cover? Think you'd be a great guest? Message our producer Kelli@BrainLadySpeaker.com and let us know.PLEASE NOTE: The information contained in this podcast is not at any time and for any reason meant to replace the guidance and/or treatment of any health professional. Whether it be a medical doctor, psychologist, psychotherapist, or anyone in the medical field. If you are under the care of such a health professional, remember this is an “added value” and not designed to replace any care you are currently under.

In this solo episode, I explore how social cues, eye contact, presence, and everyday device habits may shape the way children learn to connect with others. I also look at distractibility, stress responses, communication, and developmental reflexes, and why some behaviors labeled as attention problems may reflect a nervous system working hard to feel safe. Most importantly, I share ways adults can model stronger connection and help children build more room to regulate, engage, and learn. - - - - - About the Host: Dr. Laura Hanson is the founder of Connect My Child's Brain and a nationally recognized expert in neurodevelopment, with nearly 30 years of experience helping children and adults who struggle with focus, learning, behavior, and overall brain function. Rather than focusing on labels or symptom management, Dr. Hanson specializes in identifying the underlying patterns in brain development that impact how a person thinks, learns, and functions. She is known for helping families understand why their child is struggling—and more importantly, what can be done about it. - - - - - Connect My Brain Website: https://www.connectmybrain.com/ Instagram: https://www.instagram.com/connect.my.brain/ Facebook: https://www.facebook.com/connectmybrain Youtube: https://www.youtube.com/@drlaurahanson - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/

**Visit https://www.gatlan.com/ and use cod ‘DAVE' to unlock a free consultation!**At 53, Josh Duhamel says he feels better than he did in his 30s. Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age. Josh shares why he started TRT in his early 40s, what changed once he began tracking his hormones, and why he decided to build a health company around hormone optimization. They also discuss injectable testosterone, GLP-1s, peptide quality, hair loss treatments, stem cells, and the importance of medical guidance when experimenting with longevity tools. The conversation also gets into cognitive performance, including Josh's past struggles with forgetting lines, his interest in nootropics, and Dave's experience with Modafinil and Aniracetam. Josh explains why having a newborn and a toddler at 53 has made longevity more personal, while Dave and Josh explore the connection between physical health, spirituality, breathwork, psychedelics, and mental performance. This is essential listening for anyone interested in testosterone, TRT, peptides, nootropics, brain health, GLP-1s, healthy aging, fatherhood, hormone optimization, and longevity. You'll Learn: Why Josh started testosterone therapy in his early 40s How TRT changed his energy, strength, joints, and motivation Why testosterone levels should be individualized How injectable, oral, and topical testosterone differ Why peptide sourcing matters How GLP-1s can affect muscle and body composition What Josh has tried for hair loss Why brain performance became a major concern for him Which nootropics come up for memory, focus, and mental stamina Why becoming a father later in life changed how Josh thinks about longevity How breathwork, psychedelics, and spirituality fit into the conversation Thank you to our sponsors! - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY. - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Josh Duhamel, Gatlan Health, testosterone therapy, TRT, low testosterone, hormone optimization, injectable testosterone, testosterone cream, oral testosterone, peptides, peptide therapy, GLP-1, healthy aging, longevity, nootropics, Modafinil, Aniracetam, Dihexa, brain health, cognitive performance, hair loss, stem cells, fatherhood, men over 50, energy, muscle, strength, bloodwork, hormone testing, psychedelics, breathwork, spirituality Resources: • Visit https://www.gatlan.com/ and use cod ‘DAVE' to unlock a free consultation • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps: 00:00 – Trailer 01:15 – Intro 07:16 – Alcohol & Hangover Hacks 13:24 – Spirituality & Health 19:36 – Hormone Therapy for Women 24:45 – Inside Gatlan's Model 30:35 – Potty Training Secrets 38:39 – North Dakota & Fargo 43:57 – Hollywood's Beauty Secrets 50:19 – Acting Career & Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A letter landed on Masud Husain's desk about a man in his thirties who had stopped doing anything at all.Dr. Masud Husain is a clinical neurologist, neuroscientist, and Professor of Neurology and Cognitive Neuroscience at the University of Oxford. He is Editor-in-Chief of the journal Brain and author of Our Brains, Our Selves, winner of the 2025 Royal Society Trivedi Science Book Prize.The letter was about a man named David who had been highly productive, worked in finance, and was charming company. Then he lost his job, stopped showering, and could not be bothered to claim the benefits that would have covered his rent. Asked why he no longer listened to music, he said it would take five minutes to connect the cables.David was not depressed. He had suffered two tiny strokes in the basal ganglia, structures deep in the brain that help link motivational cues to action. Nothing was worth the effort to him anymore.After an initial treatment failed, Masud's team tried another drug that acts on the dopamine system. Three months later David came back with a haircut, a suit, a new job, and a new girlfriend.Addiction researchers had arrived at that same circuit from the other direction: Masud says it is the circuit hijacked by almost every drug of addiction. He and Mike get into what that overlap means about the science of motivation, why apathy and depression are different conditions, why there are more than 200 causes of dementia and what that means for prevention, and whether there is a self to be found in the brain at all.This is a conversation for anyone who has decided to do something and then not done it. Masud frames motivation as a calculation of whether the reward is worth the effort, and the lever most of us have is the size of the effort.After thirty years of seeing patients, the thing Masud says he has learned is that the self is not set in stone. You can change.Enjoy the conversation.______________________________________________________Links & Resources:Dr. Masud Husain's Website: masudhusain.orgDr. Masud Husain's Books: Our Brains, Our Selves: What a Neurologist's Patients Taught Him About the Brain, Oxford Textbook of Cognitive Neurology and Dementia (co-editor)Dr. Masud Husain's Journal: Brain, where he is Editor-in-ChiefSubscribe to our Youtube Channel for more conversations at the intersection of high performance, leadership, and wellbeing: https://www.youtube.com/c/FindingMasteryGet exclusive discounts and support our amazing sponsors!Go to: https://findingmastery.com/sponsors/Subscribe to the Finding Mastery newsletter for weekly high performance insights: https://www.findingmastery.com/newsletterDownload Dr. Mike's Morning Mindset Routine: findingmastery.com/morningmindsetFollow on YouTube, Instagram, LinkedIn, and X#FindingMastery #MasudHusain #DrMichaelGervais #OurBrainsOurSelves #Neuroscience #Neurology #Motivation #Apathy #Dopamine #Attention #Dementia #BrainHealth #Consciousness #Identity #HighPerformance #PsychologySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us Fan Mail "The brain actually can regenerate given the right information. You first remove the obstacles to cure through testing, and then you layer in the correct sound, light, and regenerative stem cell therapeutics to allow the body to heal itself." — Dr. Greg Eckel Can the human brain actually heal and regenerate after severe neurological decline? Mainstream medicine often says no, but Dr. Greg Eckel is clinically proving otherwise.In this powerful episode of The Remarkable People Podcast, host David Pasqualone sits down with naturopathic physician and Chinese medicine practitioner Dr. Greg Eckel. Following the heartbreaking loss of his wife Soraya to Creutzfeldt-Jakob disease (CJD), Dr. Eckel dedicated his life to answering one central question: How do we regenerate the human brain?Dr. Eckel breaks down the three main causes of protein misfolding (Environmental Toxicity, Trauma, and Infections), reveals the early warning signs of neurodegeneration that most people ignore (like loss of smell and chronic gut issues), and explains his groundbreaking Eckel Protocol—utilizing frequency sound baths, targeted light therapy, and laser-guided stem cell therapeutics to restore cognitive function. Plus, discover the #1 food you must eat daily for brain health and the #1 neurotoxin you need to eliminate immediately.Call to Action Links:Learn more about Dr. Greg Eckel's work: Be Vital Clinic / Nature Cures ClinicSupport the show and get the best sleep of your life: Visit MyPillow.com and use promo code REMARKABLE for free shipping on your entire order and up to 80% off!Support the showTHE NOT-SO-FINE-PRINT DISCLAIMER: While we are very thankful for all of our guests, please understand that we do not necessarily share or endorse the same beliefs, worldviews, or positions that they may hold. We respectfully agree to disagree in some areas, and thank God for the blessing and privilege of free will.For more Remarkable Episodes, Inspiration, and Motivation, please visit https://davidpasqualone.com/remarkable-people-podcast/ now!

Today, I am honored to connect with Dr. Zaldy Tan, a geriatric medicine and memory disorder specialist whose research career has centered on the Framingham Heart Studies Offspring Cohort. Dr. Tan currently directs Cedar Sinai's memory and healthy aging programs, after previously leading the memory clinic at Beth Israel and Harvard Medical School. His book, Age Proof Your Mind, translates his clinical and research background into a practical framework for people trying to assess and protect their own cognitive trajectory. In our conversation, Dr. Tan explains why middle age is the old age of youth and the youth of old age. We discuss common symptoms of memory issues and those that are reversible. We explore the Framingham Offspring Study and its impact on brain health over time,  looking at the effects of sleep, depression, vitamin deficiencies, alcohol, loneliness, and nutrition, and Dr. Tan shares the three Ds, dementia, delirium, and depression- the red flags he sees in his clinical practice, explains how he helps prepare caregivers for caring for loved ones with neurocognitive memory loss, and discusses late-stage issues, medications, blood-based biomarkers, and the role of genetics in brain health. Stay tuned for a truly fascinating discussion with Dr. Zaldy Tan. IN THIS EPISODE, YOU WILL LEARN: The importance of being sensitive to how your memory changes over time Various factors that could contribute to memory problems The profound effect alcohol has on the brain and neurologic function How social isolation can increase the risk of dementia in future years Dr. Tan discusses the Framingham Offspring Study and the links between metabolic dysregulation and brain MRI markers of brain aging. How the 3 Ds, delirium, dementia, and depression, can overlap The red flags in a patient's history that lead Dr. Tan to believe there may be a more serious issue What care partners should be aware of when a family member is experiencing dementia  The importance of protecting sleep and maintaining consistent sleep patterns for those with memory problems How genetic testing is incorporated into Dr. Tan's care model Bio:  Dr. Zaldy Tan is the Director of the Memory & Healthy Aging Program at Cedars-Sinai Medical Center, which U.S. News & World Report ranked in 2024 as the best hospital on the U.S. West Coast and among the top hospitals in the country. He holds the Carmen & Louis Warschaw Endowed Chair in Neurology and is a professor at the David Geffen School of Medicine, University of California, Los Angeles. Dr. Tan was the founding director of the Memory Disorders Clinic at Harvard Medical School/Beth Israel Deaconess Medical Center. Dr. Tan performs aging and dementia research covered by The New York Times, Time, CNN, The Wall Street Journal, NPR, The Washington Post, The Chicago Tribune, Reuters, ABC News, and NBC News. He regularly speaks at major national and international conferences and is the author of Age-Proof Your Mind and What to Remember When You Are Forgetting. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Zaldy Tan Dr. Tan at Cedars Sinai (Los Angeles)   On Instagram Dr. Tan's book, What to Remember When You Are Forgetting, is coming out on September 15th, 2026. Pre-order HERE.

In this episode of The Brainy Business podcast, Melina Palmer is joined by Dr. Masud Husain, a cognitive neurologist and author of Our Brains, Our Selves. They delve into the intriguing phenomenon of "quiet cracking," a term that captures the subtle erosion of motivation many employees are experiencing in today's work environment. With over half of the workforce feeling this way, understanding the underlying reasons becomes crucial. Masud shares his extensive research on motivation and decision-making, revealing how even the most driven individuals can lose their spark due to neurological changes. Through compelling stories, including that of David, a once highly motivated finance professional who suffered strokes that extinguished his drive, listeners gain insights into the complex interplay between brain function and motivation. This episode is rich with actionable insights for both individuals and employers. Masud discusses the importance of understanding the factors that influence motivation, such as perceived effort versus reward, and offers strategies for enhancing workplace morale. He emphasizes the need for small wins and timely rewards to keep motivation alive, along with the significance of social connections in combating feelings of apathy. In this episode: Explore the concept of "quiet cracking" and its impact on motivation. Learn about the neurological basis of motivation and decision-making. Discover how personal stories illuminate the complexities of brain function. Understand the importance of social connections and small rewards in maintaining motivation. Gain insights on how to foster a more engaging and supportive work environment. Get important links, top recommended books and episodes, and a full transcript at thebrainybusiness.com/595. Looking to explore applications of behavioral economics further?  Learn With Us on our website. Subscribe to Melina's Newsletter Brainy Bites.  Let's connect: Send Us a Message Follow Melina on LinkedIn The Brainy Business on Youtube The Brainy Business on Instagram

Support the show to get full episodes, full archive, and join the Discord community. The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. Read more about our partnership. Sign up for Brain Inspired email alerts to be notified every time a new Brain Inspired episode is released. To explore more neuroscience news and perspectives, visit thetransmitter.org. Andrea Gambarotto is a postdoctoral philosopher and researcher at the University of Luxembourg. He is an expert in the philosophy of Georg Wilhelm Friedrich Hegel, most commonly known as Hegel. More recently he has been studying the relation between some of Hegel's ideas and those of modern theoretical biology regarding questions of autonomy and agency. Andrea argues that, where Immanuel Kant believed we should explain biological stuff and inanimate stuff the same way- via mechanistic explanations, Hegel believed to explain the biological stuff, we should leverage the fact the biological organisms have intrinsic purpose… agency. And, Hegel's approach is in line with what's called the enactive approach in cognitive science, which has a long history and continues to thrive. Andrea explains all of that during our discussion. One reason I invited Andrea on is because these issues get the heart of what some of us care about, which is, what are the differences and similarities between our natural intelligence and engineered artificial intelligence? Why should we care about those differences? A large language model isn't alive, but does it have a mind? Should we call what it does cognition? What are the relations between life, mind, cognition, intelligence, consciousness? Those kinds of questions. We even discuss why the famed octopus might be really intelligent but not conscious. Andrea Gambarotto Gambarotto papers Enactivism and the Hegelian stance on intrinsic purposiveness Body plan organization and the evolution of conscious agency Blog: Dialectical Systems Papers also mentioned Weber & Varela 2002: Life after Kant: Natural purposes and the autopoietic foundations of biological individuality. Mossio & Bich 2014: What makes biological organisation teleological? Bechtel & Bich & 2021: Grounding cognition: heterarchical control mechanisms in biology. Pessoa 2026: Beyond networks: Toward adaptive models of biological complexity. Levins 1998: Dialectics and Systems Theory. Barandiaran & Moreno 2006: On What Makes Certain Dynamical Systems Cognitive: A Minimally Cognitive Organization Program. Books mentioned Linguistic Bodies: The Continuity between Life and Language Radical Embodied Cognitive Science An Evolutionary Story of Agency 0:00 - Intro 7:51 - Intrinsic and extrinsic purposiveness 14:39 - Hegel, Kant, and autonomy 28:07 - Constraint closure and enactivism 35:13 - How Hegel and Enactivitsm agree 43:58 - Dialectics 57:44 - Brain activity and enactivism 1:20:02 - Heidegger and cognitive science 1:26:59 - Artificial intelligence and Hegel 1:29:15 - Mind agency decoupling 1:43:38 - Evolution of conscious agency 1:52:42 - Heterarchy via McCulloch

What if one of the most fun workouts could also support your balance, bones, pelvic floor, lymphatic system, nervous system, and overall longevity? In this episode of the Health Fix Podcast, Dr. Jannine sits down with Steve Carver, aka Mr. Bouncer, a fitness professional with more than 30 years of experience and a longtime expert in trampoline-based fitness with JumpSport. What started as an unexpected introduction to JumpSport eventually became Steve's specialty: helping people understand just how versatile a rebounder can be. And this isn't just about jumping up and down. A rebounder can be used for gentle workout, strength training, balance work, plyometrics, sports-specific conditioning, HIIT, and even ski training. Dr. Jannine and Steve dive into why bouncing may be worth adding to your movement routine, especially as you get older. In This Episode, You'll Learn: How rebounding supports balance, strength, and coordination Why gentle bouncing may benefit lymphatic flow and pelvic floor health How rebounding can support bone health and agility Why 5–10 minutes of movement is all it takes to make a difference How to adjust your bounce for gentle movement or higher-intensity workouts Using rebounding for ski training, HIIT, and sport-specific conditioning Why the lymphatic system loves movement Unlike the circulatory system, the lymphatic system doesn't have its own pump. Movement and muscular contractions help move lymphatic fluid through the body. Steve explains how the compression and release created through bouncing may help encourage lymphatic flow, making gentle bouncing a simple and enjoyable way to incorporate movement into your routine. The fun factor matters One of the biggest takeaways from this conversation? The best exercise is the one you'll actually do. Steve shares why he believes enjoyment is such an important part of movement. If you hate the exercise you're doing, your brain will eventually find a reason to avoid it. But when movement makes you smile, feel energized, and actually look forward to exercising, consistency becomes a whole lot easier. Meet Steve Carver Steve Carver, aka Mr. Bouncer, has more than 30 years of experience as a fitness professional, trainer, stunt performer, and trampoline fitness expert. His background includes competitive sports, extreme sports, skiing, acrobatics, stunt work, and training clients in the entertainment industry. Today, Steve works with JumpSport to help people discover the many ways a rebounder can be used for fitness, wellness, balance, conditioning, and more. Connect with Steve & JumpSport Learn more about JumpSport, rebounder fitness, workouts, and products at JumpSport.com. You can also find JumpSport Fitness on social media for workouts and inspiration. Get 10% off a JumpSport trampoline now! - https://www.jumpsport.com/HEALTHFIX Steve Carver Instagram: https://www.instagram.com/carvercompletefitness/ JumpSport Instagram: https://www.instagram.com/jumpsportfitness/ Connect with Dr. Jannine Krause Check out Dr. Krause's Website for more resources and subscribe for more conversations on functional medicine, longevity, brain health, hormones, nutrition, and natural strategies to optimize your health. Be sure to Like, Subscribe, and Share this episode with someone who wants to protect their brain and age with vitality. This episode of Health Fix Podcast is sponsored by Chemical Free Body - home of Dr. Krause's favorite green juice - Organic Energy Juice - enter "thehealthfix" for 15% off your 1st order. 

In this episode, I tell you why you should be inspired by a can of WD-40, and how ADHD humans should be proud of how easily they take risks, but need to get better at failing. Special offer to join my online co-working community! Get 2 weeks free! Use this link: https://jenkirkmancowork.circle.so/checkout/2weeksfree Mentioned in this episode - the book, "Rejection Proof" by Jia Jiang For ad-free episodes, video versions, transcripts, a second ad-free Patreon only episode every Friday, and live Q&A's with Jen, support by subscribing to Patreon at just $7.99/mo or get 15% off if you pay annually. You'll get to suggest episode ideas as well! **Take a somatics class with Jen! Click here.** Get on the mailing list about Somatics Classes with Jen here. **Join Jen's New Co-Work Community online! I started something called ☕️The Co-Work Community. It's an online co-working (aka body doubling) space & community for neurodivergent humans! There are other online co-working spaces but where else can you do your work, tasks, or chores with other neurodivergent people and ME, every single day for ONLY $15 a month? Answer? Nowhere! You'll help yourself AND you're supporting a neurodivergent solopreneur woman-owned start-up business.**** Want to get a weekly wrap-up of the "You Are A Lot" ADHD/AUDHD Podcast with special offers and tips? Sign up for the every Saturday newsletter Get the ADHD To Do List Coffee Mug From Jen's Shop! Shop The Be Nice To Me I Have ADHD Collection (totes, tees, magnets, and more!) from Jen's Shop Shop The Be Nice To Me I'm AuADHD Collection (totes, tees, magnets, and more!) from Jen's Shop Shop Jen's Favorite ADHD Supports (with Discounts) Jen's Printables I created these printables (or write directly in them online as digital downloads) for people who love having fun little extras to add to their systems. I have journal prompts, easy mode to do lists, places to log books you've read/books to read, places to thought spiral and sort, as well as ADHD Guides filled with facts. Brain.fm — A Focus Tool I Use Every Day I listen while I work and I can feel my brain lock in. It's not AI. It's science-backed sound made by musicians and scientists for ADHD brains. I want you to try it for 30 days free, with my link! Get 25% off WisprFlow. It's a talk to text app that helps me as a person who needs to verbally write sometimes, whether it's a brain dump journal entry or composing an episode of this podcast. It types very fast and always understands my words perfectly. Little Ouchies - Self Regulation Stim Tools! I LOVE my Little Ouchies. I use them daily when I'm working, writing, thinking, and it really helps me to stay in the moment by regulating my nervous system. I tend to ruminate with Imposter Syndrome when I'm in deep work. It's also just fun and feels good, so even watching TV or other mindless activities are made more stimulating by rolling one in my hands. Get 10% off with this link and use ALOT10 at checkout! Hugimals — Weighted Comfort for Kids/Adults. I own Hugimals, give them as gifts, and love that they're made by a neurodivergent founder who understands nervous system needs. These weighted stuffed animals and pillows help with anxiety and overwhelm, and you can get 15% off anytime using my link and code JENKIRKMAN (it never expires). Books I Recommend I love Bookshop.org because every purchase supports your local independent bookstore, not Amazon, while still shipping directly to you. I've curated book lists on ADHD/AuDHD and mental health, and you can get 20% off everything when you shop using my link. The Shakti Mat - I have found it to be a feel-good experience to lie down on a mat full of prickly plastic spikes. It's that simple. It feels good. Lying down on Shakti spikes activates hundreds of acupoints to promote circulation, release tension, and restore energy. The Time Timer - a Cute Visual Time Tool! I use my Time Timer every single day to help me visualize time during work blocks, and to gamify chores. There's no discount, but when you use my link I earn a percentage that goes directly into supporting this podcast. The Big A## Calendar I have the Big A## wall calendar that maps out the entire year and the Big A## personal planner with 365 days in one view, dry erase markers, color coded labels. With my unique link you can get 10% off of your order. Appointed — Planners, Notebooks and Desk Goods. Appointed notebooks are my go-to for my spiral notebooks, day planners, calendars and Le Pen pens for list-making, journaling, and planning. Save 15% off with my link and code JENKIRKMAN.

In this episode of Business Brain, we take you inside both sides of a domain negotiation. Shannon wanted resellerrocket.com, found it sitting on a generic affiliate parking page, and opened at $2,300 against a $4,000 ask — then used AI to land on an oddly specific counter just under $2,700 that got accepted on the spot. Dave plays the other side: an unsolicited inbox offer on a domain he’d been paying registration fees on for twenty-plus years, a Claude-assisted valuation, a $15,000 ask, and a $10,000 close with the buyer eating the escrow fees. The rule you can steal today — buy with math, sell with emotion. And when someone tries to turn a price into a monthly payment, remember what FFE really stands for. Then we put your favorite management line on trial. How can I help sounds generous, but it hands your team a blank slate and makes them do the work of delegating to themselves. You’ll hear why specific beats open-ended, why Shannon walks the floor every morning emptying trash cans while he reads the room, and why he lets his people set their own KPIs instead of handing them down. The upgrade is straightforward: tell your team you’ll do anything you can to help them succeed, then put your skills, your network, and your tools on the table as resources they’re allowed to use. Expect it to take a while before they believe you. Getting there is the charmed life — a team that finally tells you what they actually need. 00:00:00 Business Brain – The Entrepreneurs' Podcast #788 for Wednesday, September 16th, 2026 September 16th: Working Parents Day 00:02:04 Domain Negotiating ResellerRocket.com Spaceship.com (hopefully they're a domain broker!) 00:11:56 SPONSOR: SomniPods 3 sleep earbuds from Fitnexa: Flat enough to sleep on, and the app is the real prize: https://go.fitnexa.com/brain automatically applies $10 off (or use code BRAIN). 00:13:29 SPONSOR: Hims. With Wegovy® at Hims, lose up to 20% of your body weight when combined with diet and exercise. Visit https://hims.com/businessbrain to get a personalized, affordable plan that gets you. 00:15:17 Revisiting “How can I help?” 00:24:26 Business Brain 788 Outtro This Episode's Big Takeway: Be Mindful of How You Can Offer Help To Your Team Check out Business Brain Blueprints Tell Your Friends! Business Blueprints Review Business Brain Subscribe to the show feedback@businessbrain.show Call/Text: (567) 274-6977 X/Twitter: @ShannonJean & @DaveHamilton, & @BizBrainShow LinkedIn: Shannon Jean, Dave Hamilton, & Business Brain Facebook: Dave Hamilton, Shannon Jean, & Business Brain The post Domain Negotaiting and HCIH Follow Up – Business Brain 788 appeared first on Business Brain - The Entrepreneurs' Podcast.

Carolina Reis de Oliveira on Reversing Skin Age, Menopause, GLP-1 Skin, and the Science of Senescent Cells Your skin is likely biologically older than you are, but new research suggests some of that aging may be reversible. **For Dave's listeners only, visit oneskin.co/Dave for exclusive early access to the OS-01 Face Rich Cream!**Host Dave Asprey sits down with Carolina Reis de Oliveira, PhD, CEO and co-founder of OneSkin. Carolina holds a PhD in stem cell biology and tissue engineering, is a co-inventor of five patents, and has co-authored numerous scientific publications. She and her team are studying skin longevity by targeting one of the central drivers of aging: the accumulation of senescent cells. They break down why skin loses its ability to hold water as you age, and why that process can accelerate dramatically during perimenopause and menopause. Carolina explains the skin's "brick and mortar" barrier system, how declining estrogen affects collagen, ceramides, cholesterol, hyaluronic acid, and elastin, and why simply sealing moisture into your skin with occlusive products does not solve the underlying biology. They also explore why GLP-1 users can experience loose or sagging skin after rapid weight loss and what may help preserve skin structure over time. Carolina reveals how her team screened hundreds of peptides to develop OS-01, a senomorphic peptide designed to reduce the damaging signals produced by senescent "zombie" cells while supporting healthier skin function. In their research, OS-01 reduced markers of cellular senescence and inflammation, increased collagen production, and was associated with a 2.5-year reduction in measured biological skin age. She also explains why more peptides are not necessarily better, why some GHK-Cu formulations may fail to perform, and why peptide stability, concentration, delivery, and formulation matter. The conversation also covers why the skin around your eyes may biologically age decades faster than your cheeks, whether topical collagen really works, why cholesterol is essential for a healthy skin barrier, how over-moisturizing and "slugging" can backfire, and how damaged skin may contribute to systemic inflammation. Carolina also shares clinical data on OneSkin's new OS-01 Rich moisturizer, including improvements in hydration, firmness, fine lines, wrinkles, collagen, hyaluronic acid, and elastin. This is essential listening for anyone serious about skin longevity, anti-aging, menopause, GLP-1 weight loss, collagen, senescent cells, peptides, biological age testing, inflammation, hydration, hair and skin health, and maintaining younger-looking skin as you age. You'll Learn: -Why menopause can rapidly accelerate dry, thin, and crepey skin -How your skin's natural barrier holds water and why it breaks down with age -Why GLP-1 weight loss can make loose and sagging skin more noticeable -How senescent "zombie" cells accelerate inflammation and collagen loss -How OS-01 was associated with a 2.5-year reduction in biological skin age -Why skin around your eyes may be biologically much older than skin on your cheeks -Why topical collagen is different from collagen amino acids and collagen-producing signals -How cholesterol, ceramides, fatty acids, and hyaluronic acid support skin hydration -Why some GHK-Cu peptide products may not perform as expected -How over-moisturizing, face masks, Vaseline, and "slugging" can disrupt the skin barrier -How scientists measure the biological age of skin with epigenetic clocks -Why healthier skin may help lower inflammation throughout the body Thank you to our sponsors! - ZenBud | Dave's Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Calroy | Go to calroy.com/dave for your discount. - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Carolina Reis de Oliveira, OneSkin, OS-01, skin longevity, skin biological age, skin age reversal, senescent cells, zombie cells, menopause skin, perimenopause skin, GLP-1 weight loss, loose skin, crepey skin, skin hydration, skin barrier, collagen production, hyaluronic acid, elastin, ceramides, cholesterol skin, GHK-Cu, copper peptide, peptides, epigenetic skin clock, MoClock, fine lines, wrinkles, skin firmness, slugging, topical collagen Resources: • OneSkin | Get Early Access To OS-01 Rich Cream: oneskin.co/Dave • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps: 00:00 — Trailer 01:33 — Meet Carolina & OneSkin 04:31 — Skin Hydration Decline 11:46 — How the Peptide Hydrates Skin 18:20 — Zombie Cells Explained 23:32 — Discovering Peptide OS-01 32:44 — Measuring Biological Skin Age 39:00 — Skincare Philosophy for Men 43:32 — Body Lotion & Inflammation 50:09 — New Rich Cream Data See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Did consciousness lead to us having feelings, or was it the other way around? Antonio Damasio is David Dornsife Professor of Neuroscience, Psychology, and Philosophy, and director of the Brain and Creativity Institute at the University of Southern California. He joins host Krys Boyd to discuss why he believes consciousness came before feelings and why feelings came early in the evolutionary process. Plus, we'll ponder how many other organisms are aware of their existence. His book is “Natural Intelligence and the Logic of Consciousness.” Learn about your ad choices: dovetail.prx.org/ad-choices

In his new book, “Natural Intelligence and the Logic of Consciousness,” pioneering neuroscientist Antonio Damasio synthesizes his decades of research in neurobiology and philosophy of mind into a central idea: we are  conscious because we feel. “It is traditionally said that we are able to feel our feelings because we are conscious,” he writes, but instead, “we must be able to feel in order to become conscious.”  We talk to Damasio about his lifetime of research into the mind and his thoughts on the possibility of conscious AI. Guests: Antonio Damasio, psychology, philosophy and neurology professor and director of the Brain and Creativity Institute, University of Southern California; author, “Natural Intelligence and the Logic of Consciousness” Learn more about your ad choices. Visit megaphone.fm/adchoices

Brain fog isn't just a normal part of getting older—and it may not be a brain problem at all. If you struggle to focus, lose your train of thought, forget why you walked into a room, or feel mentally exhausted after eating, your body may be trying to tell you something. Here's what I discuss in today's episode: The five foods I most commonly see contributing to brain fog—and why some seemingly “healthy” choices may be working against you The surprising connection between your gut and your ability to think, focus, and remember Why certain foods can affect your brain even when you don't have obvious digestive symptoms Brain fog is a messenger, not the root problem. When you start looking at what's happening throughout your body—especially your gut, blood sugar, inflammation, and microbiome—you can begin uncovering what's getting in the way of a clearer, healthier brain. Resources Mentioned: Learn more about my 10-Day Detox Diet, a whole-food reset designed to help identify common food triggers, stabilize blood sugar, and support gut health: https://10daydetox.com Have a question you'd love answered on Office Hours? Submit it here. 0:00 Introduction, Dr. Hyman's experience, and foods contributing to brain fog 1:31 Functional medicine and the gut-brain connection 2:30 Vagus nerve, gut microbiome, and inflammation 4:21 Long COVID, gut damage, and ultra-processed foods 6:51 Alcohol, artificial sweeteners, and their effects on the brain 9:51 Dairy, gluten, and elimination diets 15:41 Ten Day Detox Diet, food journaling, and reintroducing foods 18:23 Personalized nutrition, functional medicine, and conclusion

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Michael Davidson is a world-renowned cardiologist, lipidologist, and the founding CEO of NewAmsterdam Pharma. He begins this episode by sharing how his family history shaped his interest in lipidology and primary prevention. He explains why prevention should focus on causal drivers of disease rather than near-term risk and examines the causal relationship between LDL and atherosclerotic cardiovascular disease. Michael then traces the complicated history of CETP inhibitors—from the original rationale that raising HDL would reduce cardiovascular risk to the failures of torcetrapib, dalcetrapib, and evacetrapib—and explains how lessons from these trials ultimately led to the development of obicetrapib. He reviews the phase 2 and phase 3 trials of obicetrapib, its effects on LDL-C, apoB, LDL particle number, and Lp(a), the ongoing cardiovascular outcomes trial, and where the drug could fit alongside statins and other lipid-lowering therapies. Peter and Michael discuss the relationship between statins and diabetes risk, then turn to the potential role of obicetrapib in Alzheimer's disease prevention, exploring the genetics of APOE4 and CETP, cholesterol metabolism within the brain, and emerging biomarker data. Finally, Peter and Michael explore the benefits of omega-3 fatty acids and the challenge of delivering DHA to the brain, as well as ongoing work on klotho in preparation for clinical trials. They discuss the potential for AI to transform clinical trials and the scientific and financial challenges of developing new therapies for cardiovascular and neurodegenerative disease. We discuss: Michael's path to lipidology, and his passion for primary prevention [3:30]; Reframing prevention around causal drivers rather than time horizon [9:30]; What CETP inhibition does, the evolutionary biology of CETP, the HDL-raising rationale, and Pfizer's torcetrapib failure [15:00]; Why raising HDL is thought to be beneficial, a quick review of the functions of HDL, and how this connects to torcetrapib [24:00]; The graveyard of CETP inhibitors: Roche's dalcetrapib, Lilly's evacetrapib, and Merck's REVEAL trial [27:15]; The causality of LDL in cardiovascular disease [34:30]; Reviving obicetrapib at NewAmsterdam, and confirming the benefit is LDL lowering: the TULIP data, the abandoned statin-intolerance path, and the Mendelian randomization verdict on HDL [37:30]; Phase 2 and phase 3 trials of obicetrapib—ROSE, BROOKLYN, BROADWAY, and TANDEM—and the PREVAIL outcomes trial, with the European and US approval paths [44:45]; Discordance among LDL-C, LDL-P, and apoB with CETP inhibition, and obicetrapib's Lp(a)-lowering effect [50:30]; Where obicetrapib fits in the lipid-lowering toolkit, the case against high-dose statins, and the problem of drug pricing [57:30]; The case for obicetrapib in Alzheimer's: the APOE4 and CETP genetics, the animal models, and funding Alzheimer's research [1:03:45]; Brain cholesterol metabolism and the APOE4 mechanism: the blood-brain barrier, astrocyte cholesterol efflux, the amyloid-tau cascade, the role of HDL, and why statins don't cause Alzheimer's disease [1:08:00]; The biomarker evidence: the CSF pilot study, Alzheimer's as a disease of middle age, the pharma graveyard problem, and the p-tau 217 results from BROADWAY [1:17:45]; Whether obicetrapib translates into clinical benefit for Alzheimer's disease: the risk of fooling yourself, the persistence of the amyloid dogma, ARIA in APOE4 homozygotes, and the next prevention trial [1:28:00]; Fish oil, EPA, and DHA: the cardiovascular trials and the challenge of delivering DHA to the brain [1:32:00]; Two open problems: using AI to reform clinical trials, and the statin–diabetes signal [1:41:15]; What it takes to develop a drug, the biotech investment landscape, and the klotho program [1:48:15]; Closing reflections: what to do if you carry APOE4, balancing motivation against over-testing, and the need for multiple therapies [1:55:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

What do special guests and brain freezes have in common? This episode of WeWow, the bonkerballs variety show for kids and families from the creators of Wow in the World, has all of that and more. Dennis and Reggie are back with another weekend full of laughs, listener love, and a frosty encore episode that'll have the whole family talking all over again. Whether you're a longtime Wowzer or just tuning in, WeWow on the Weekend is the kind of family variety podcast that makes every car ride, breakfast table, and slow Sunday morning a little more wow-worthy.This week, Dennis and Reggie are joined by special guest Post Officer Jellybird! And if that's not enough, WeWow on the Weekend wraps up with a fan-favorite encore of "Brain Freeze!" from Wow in the World—an episode about ice cream headaches, packed with big ideas, bigger laughs, and the kind of curiosity that makes the whole family lean in."Brain Freeze!" originally aired on July 24th, 2017, and explores what causes "brain freeze" when you eat a cold treat too quickly! Dennis and Reggie revisit all the wow-worthy moments and bring their signature bonkerballs energy to a topic that's equal parts wild, important, and totally fascinating.WeWow on the Weekend is part of the Tinkercast family of podcasts, created by the award-winning team behind the #1 science podcast for kids and families, Wow in the World. Every weekend, Dennis and his co-host Reggie answer listener questions, respond to fan reviews, play games, and celebrate the best moments from across the Tinkercast universe. It's a talk, talk, talk show unlike any other — and it's always better when YOU'RE part of it.Want to hear your name on WeWow? Send Dennis a question or leave a podcast review for a chance to be featured on the show! You can also leave a message for Dennis at 1-888-7WOW-WOW!Grownups, want to keep the Wow going? Join the World Organization of Wowzers (W.O.W.) at tinkercast.com/joinwewow and your Wowzers will receive quarterly mailings, birthday cards, a welcome kit with a t-shirt, autographed photo of Mindy & Guy Raz, access to 1,000+ digital activities, and exclusive access to members-only events!This episode of WeWow is the perfect family variety podcast for Wowzers of all ages, full of Post Officer Jellybird and ice cream headaches that will blow your socks off.Originally aired 10/1/23.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.