Podcasts about Movement disorders

president disease defining parkinson headed movement disorders

Play Episode Listen Later Jan 13, 2025

Dr. Michele Matarazzo interviews Dr. Victor Fung, President of the International Parkinson and Movement Disorder Society and lead author of the recent viewpoint published in the Movement Disorders journal. Together, they explore the biological definition and classification of Parkinson's disease, discussing its key insights, future prospects, and the implications of recent advances in the field. Read the article.

Neurological Knock-Knock – Who's There? Movement Disorders!

Join the Docs

Play Episode Listen Later Dec 10, 2024 61:32

In this enlightening episode of Join the Docs, the ever-curious Professor Jonathan Sackier and the delightfully witty Doctor Nigel Guest dive deep into the gray matter (pun absolutely intended) to untangle the mysteries of the human brain and its trusty sidekick, the nervous system. Who are the guests this week? Joining this week is the insightful Ione Georgakis, an Occupational Therapist and Advocacy Manager for Tourette Action and Dr. Ed Palmer, a fellow Tourette expert and psychiatrist.. Ione and Ed bring a synapse-worthy amount of knowledge and compassion to the discussion, shedding light on the challenges faced by individuals with Tourette syndrome and other movement disorders. Their expertise in therapeutic interventions and advocacy adds a crucial nerve center to the conversation, underscoring the importance of holistic care and patient empowerment. How does the brain orchestrate movement? The dynamic trio pirouettes straight into the topic, exploring the brain's role as the maestro of movement. Tremors are likened to an over-caffeinated squirrel, while rigidity gets compared to the Tin Man pre-lube job, adding just the right amount of levity to complex concepts. When Parkinson's disease is discussed, The Docs examine it with a careful and informed approach. Diagnosing the condition, they explain, requires a balance of scientific knowledge and clinical judgment, as the symptoms can be subtle and vary from person to person. Treatment options are diverse, including medications and deep brain stimulation, a procedure that involves implanting a device to help regulate brain activity and manage symptoms more effectively. The laughs don't come at the expense of insight. Stories pepper the episode like synaptic sparks. Ione and Ed add their own heartwarming anecdotes of resilience and triumph, illustrating how tailored therapies and supportive communities provide vital nourishment for those living with movement disorders.What will you take away from this episode? By the episode's end, listeners will have a newfound appreciation for the pun-damental intricacies of the human brain, a smile on their faces, and perhaps an irresistible urge to break out into dance—just remember to thank your motor neurons! —--DISCLAIMER: The views and opinions expressed on Join the Docs are those of Dr. Nigel Guest, Jonathan Sackier and other people on our show. Be aware that Join the Docs is not intended to be medical advice, it is for information and entertainment purposes only - please, always take any health concerns to your doctor or other healthcare provider. We respect the privacy of patients and never identify individuals unless they have consented. We may change details, dates, place names and so on to protect privacy. Listening to Join the Docs, interacting on our social media, emailing or writing to us does not establish a doctor patient relationship.To Contact Us: For a deeper dive on this episode's issue, merchandise and exclusive content, head to www.jointhedocs.comFollow us on youtube.com/JoinTheDocs Follow us on instgram.com/JoinTheDocsFollow us on tiktok.com/JoinTheDocsFollow us on: facebok.com/JoinTheDocsFollow us on: x.com/JoinTheDocs

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World Movement Disorders Day: Stigma in pediatric movement disorders

stigma pediatric movement disorders sara schaefer world movement

Play Episode Listen Later Nov 27, 2024

Dr. Sara Schaefer interviews Dr. Jaclyn Martindale on stigma in the experiences of individuals with pediatric movement disorders and tic disorders. They discuss the reasons behind stigma, types of stigma, and ways that stigma is perpetuated and mitigated in this special episode for World Movement Disorders Day 2024.

World Movement Disorders Day: How to fight stigma in Parkinson's disease

disease parkinson stigma movement disorders world movement

Play Episode Listen Later Nov 26, 2024

Dr. Indu Subramanian shares her view on stigma affecting people with Parkinson's disease, along with some practical tips on how to fight it as doctors and as a society.

Epilepsy Explained: What It Is And What To Do

Baptist HealthTalk

Play Episode Listen Later Nov 25, 2024 21:27

Today's episode is a look into a condition that affects millions every day, epilepsy. While it's impact and triggers can be overwhelming, the latest advancements in medicine offer much hope for patients and their families alike. Host:Willard ShepardAward-Winning JournalistExperts:Dr. Pooja Patel, M.D.Neurologist Director of the epilepsy monitoring unit at Marcus Neuroscience InstituteDr. Luis Felipe Tornes, M.D.NeurologistDirector of the epilepsy program at Baptist Health Miami Neuroscience Institute

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World Movement Disorders Day: Stigma in movement disorders

stigma movement disorders sara schaefer world movement

Play Episode Listen Later Nov 25, 2024

Dr. Natasha Fothergill-Misbah discusses stigma in movement disorders with Dr. Sara Schaefer, including the origins, types, and consequences of stigma, and how stigma may be perpetuated and combatted around the world.

An Inside Look at the Edmond J. Safra Fellowship in Movement Disorders with Marcelo Merello and Sergio Castillo-Torres

The Michael J. Fox Foundation Parkinson's Podcast

Play Episode Listen Later Nov 5, 2024 57:54

To help meet the growing global need for more movement disorders specialists, The Michael J. Fox Foundation created the Edmond J. Safra Fellowship in Movement Disorders in collaboration with longtime partner the Edmond J. Safra Foundation. This program supports the training of movement disorders specialists who will provide expert care and drive advances in Parkinson's research. The program is positively impacting early-career clinician-researchers, as well as the centers where they train. These impacts will continue to grow over the years as more fellows are trained. In this episode, Dr. Marcelo Merello and Dr. Sergio Castillo-Torres share their insights and perspectives as a Fellowship Director and a Fellow in the program, respectively. Marcelo is Director of the Department of Neurosciences and Chief of the Movement Disorders Clinic at the Institute for Neurological Research or Fleni Hospital. He is fellowship Director at Fleni and the University of Buenos Aires. In addition, Marcelo is Principal Investigator with the National Council for Scientific and Technical Research and Professor of Neurodegenerative Diseases at the Pontifical Catholic University of Argentina. Sergio is an Associate Professor in Neurology and Internal Medicine at the Dr. Jose E. Gonzales University Hospital of the Autonomous University of Nuevo Leon. He was an Edmond J. Safra Fellow in Movement Disorders at Fleni Hospital. Visit michaeljfox.org/fellowship to learn more about the Edmond J. Safra Fellowship in Movement Disorders.This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

26: An Inside Look at the Edmond J. Safra Fellowship in Movement Disorders with Marcelo Merello and Sergio Castillo-Torres

The Parkinsonâ€™s Research Podcast: New Discoveries in Neuroscience

Play Episode Listen Later Nov 5, 2024 57:54

To help meet the growing global need for more movement disorders specialists, The Michael J. Fox Foundation created the Edmond J. Safra Fellowship in Movement Disorders in collaboration with longtime partner the Edmond J. Safra Foundation. This program supports the training of movement disorders specialists who will provide expert care and drive advances in Parkinson's research. The program is positively impacting early-career clinician-researchers, as well as the centers where they train. These impacts will continue to grow over the years as more fellows are trained. In this episode, Dr. Marcelo Merello and Dr. Sergio Castillo-Torres share their insights and perspectives as a Fellowship Director and a Fellow in the program, respectively. Marcelo is Director of the Department of Neurosciences and Chief of the Movement Disorders Clinic at the Institute for Neurological Research or Fleni Hospital. He is fellowship Director at Fleni and the University of Buenos Aires. In addition, Marcelo is Principal Investigator with the National Council for Scientific and Technical Research and Professor of Neurodegenerative Diseases at the Pontifical Catholic University of Argentina. Sergio is an Associate Professor in Neurology and Internal Medicine at the Dr. Jose E. Gonzales University Hospital of the Autonomous University of Nuevo Leon. He was an Edmond J. Safra Fellow in Movement Disorders at Fleni Hospital. Visit michaeljfox.org/fellowship to learn more about the Edmond J. Safra Fellowship in Movement Disorders.This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

Better understanding functional movement disorders • 2024 MDS Congress

congress functional movement movement disorders

Play Episode Listen Later Oct 7, 2024

Dr. Alexander Lehn breaks down functional movement disorders; what is happening in the brain, what are the potential risk factors and what future treatments and clinical trials we have to look forward to.

MDJ Review Article of the Year: Subjective Cognitive Complaints in Parkinson's Disease

disease parkinson complaints cognitive subjective movement disorders sara schaefer

Play Episode Listen Later Sep 27, 2024

Dr. Sara Schaefer interviews Dr. Jennifer Goldman about her systematic review and meta-analysis on subjective cognitive complaints in Parkinson's disease, including the prevalence, epidemiology, and correlation with objective cognitive findings and neuropsychiatric disease. The article was recently named the Movement Disorders journal Review Article of the Year.

Autoimmune Movement Disorders With Dr. Bettina Balint

Continuum Audio

Play Episode Listen Later Aug 28, 2024 21:46

Autoimmune cerebellar ataxia and other autoimmune movement disorders encompass a broad spectrum of different clinical syndromes, antibodies, and immunopathophysiologic mechanisms. Given the overlap between phenotypes and antibodies, panel testing in serum and CSF is recommended. In this episode, Gordon Smith, MD, FAAN, speaks with Bettina Balint, MD, author of the article “Autoimmune Movement Disorders,” in the Continuum August 2024 Autoimmune Neurology issue. Dr. Smith is a Continuum® Audio interviewer and professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Balint is an assistant professor for clinical research on complex movement disorders and Parkinson's diseases, a consultant neurologist, the head of the Department of Movement Disorders, and co-lead for the Centre for Movement Disorders and Functional Neurosurgery in the Department of Neurology at the University Hospital Zurich in Zurich, Switzerland. Additional Resources Read the article: Autoimmune Movement Disorders Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @gordonsmithMD Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME. Dr Smith: This is Dr Gordon Smith. Today, I'm interviewing Dr Bettina Balint about her article on ataxia and other autoimmune movement disorders, which appears in the August 2024 Continuum issue on autoimmune neurology, which is a highly anticipated and exciting issue. Dr Balint, welcome to the podcast, and, perhaps, you can just introduce yourself to our audience and tell us a little bit about your practice and how you became interested in this topic. Dr Balint: Thank you, Gordon, for having me. I am an assistant professor for clinical research in complex movement disorders and Parkinson's disease at the University of Zurich and the Head of the Movement Disorders Department at the University Hospital in Zurich. So while I'm originally German (from Heidelberg), I have now been to Switzerland since end of 2021. Dr Smith: So, you know, how many movement disorder chiefs have a focus on autoimmune movement disorders? I found that really interesting. Most of the movement disorder folks I interact with, their primary interest is in neurodegeneration. Dr Balint: Very good question. Even so, I never asked myself that question, really, but I think I'm the only one with this designated focus as such. Many people come from the neurology angle - most of them. Even so, movement-disorder people really welcome this field and are interested, but I think somebody who has dedicated their interest and time to it? I think I can't actually think of many other people. Dr Smith: Yeah, I think it's really cool, and, of course, autoimmune neurology is the flavor of the day these days, right? I mean, I remember when I was at the University of Utah, we were recruiting Stacy Clardy (who I think many of our listeners will know). I remember thinking, you know, she's never going to be busy. How many of these autoimmune problems are there, really? And she was, like, deluged when she came. These are really common problems. I guess that was one question I had for you. You know, we think of these as rare disorders, and when we look at the article, you have these tables of these antibodies, and a lot of them are pretty uncommon – but, cumulatively, how common are autoimmune movement disorders? Dr Balint: It's a very difficult question, because we don't have good epidemiological data. And if you look at series, I mean, most papers addressing this issue come actually from the ataxia field. And then, depending on where you look at, you might find varying numbers, and they might be also influenced by the fact that they come from ataxia centers with own certain biases. Even so, it's very close to my heart, but, I also still think it's overall very rare. So, in my practice, I see all sorts of movement disorders, and overall, they're still quite rare, but the point is that they are treatable and have important management implications, so you want to be sure not to miss any of them. Dr Smith: Well, maybe we can go to that next. Part of the challenge here, of course, is there's just so many of these different syndromes and antibodies. Are there pearls that you can provide our listeners that would help them guide when they should be thinking about these disorders when they confront a patient with a particular phenotype? Like ataxia, for instance - you know, there are certain aspects of the clinical scenario that should trigger, “Wow, this might be an autoimmune problem”. Dr Balint: So, in general, I would say there are certain scenarios where you would want to think of an autoimmune etiology in your differential. One is a very characteristic phenotype. So, speaking broadly in terms of movement disorders, stiff-person spectrum disorders have a very characteristic phenotype which you need to recognize, and then you will be able to see it when a patient enters. Important phenotypes to know which are very characteristic are faciobrachial dystonic seizures, for example, with anti-GA1 antibodies, or pseudofinalistic movements in non-REM sleep is IgLON5 antibodies, leg myoclonus is CASPR2 antibodies. I don't want to necessarily enumerate all the scenarios. The point here is there are some characteristic phenotypes where you would think of autoimmune neurology. Another scenario where you would think of autoimmune, for example, the context of late-onset paroxysmal movement disorders. So, classically, when we think of paroxysmal dyskinesia, we think of a group of genetic disorders, but if somebody develops a paroxysmal movement disorder later in life in adulthood, then you would think of autoimmune neurology, and this applies also in the context of episodic ataxias. Another red flag might be a propensity to autoimmunity. For example, somebody with type one diabetes and vitiligo coming in for cerebellar ataxia, of course, you would think of anti-GAD ataxia. And, similarly, if somebody has recently been diagnosed with a cancer and develops a rapidly disabling syndrome, of course, then you would think of a paraneoplastic autoimmune disorder. And with autoimmune syndrome, there are some symptoms which are also like tell-tale signs. So, for example, somebody with a stiff-person spectrum disorder, an ataxia with long-lasting diarrhea over months, losing weight - investigations haven't found anything, then you would think of DPPX antibodies or celiac disease. Or, if you have, like, a neuropathic pain which is otherwise not explained, then you might think of CASPR2 antibodies in somebody with a cerebellar ataxia. So, there are some features of some antibodies. (Again, I will not now list all of them which might point you to a diagnosis.) Then, of course, another scenario which is important, I think, is if you have a hemisyndrome without a structural lesion on imaging. Classically, neurologists are trained to think of a hemisyndrome - we look for a lesion on the contralateral side. But if you have, like, for example, a hemichorea without a lesion or a hemiataxia without a lesion, one should also think of an autoimmune disorder with antibodies. And then, more generally, of course, if you have changes on brain MRI or information on CSF, of course, if the clinical cause is more rapidly progressive - and last, but not least, if somebody does not really fit into our categories of the degenerative symptoms or metabolic syndromes or functionality disorders, then, of course, one should just take a step back and think, could it be something autoimmune? Having said that, if I may, I just want to say that, I mentioned that rapid disease course, and on the other hand, it's important to stress that a slowly progressive disease cause does not exclude an autoimmune etiology. Dr Smith: So, that was a great summary. Thank you. I don't know if you're familiar with the term “Aunt Minnie” (something I learned in medical school and radiology). There are certain findings that are “Aunt Minnie”, you know what “Aunt Minnie” looks like, and if you see these particular findings, you should really think about a specific disease - and I think you gave a lot of pearls in that answer, so I appreciate that. This may seem like a bit of a random question, but it's interesting that there are some of these phenotypes that do replicate genetic phenotypes, and you used episodic ataxia, which, in a younger individual, we think of a spectrum of various genetic disorders. Is that random, or are there instances where the underlying mutation in a genetic disorder actually serves as a target for autoimmunity in a later-onset autoimmune problem? Not that the mutation causes autoimmunity, but are there shared targets - in one disease it's the mutation, and another, there's an antibody that binds to the protein, for instance? Dr Balint: That's an excellent topic, and even though it's not addressed in the Continuum article, I actually covered this in an article in Brain from 2018, where we also discuss parallels (immunogenetic parallels) with targets seen in genetic disease or in autoimmune disease, and there are actually some examples for cerebellar ataxia, and some of the targets are, indeed, the same for the antibodies and mutation. And some targets are a little bit more difficult, because for those, the antibodies would probably not be pathogenic, but it's more like an autoimmune overall target but it's T-cell mediated. But, for example, water-gated, um, calcium channels - we have antibodies and we have mutations. Or, another example would be glycine receptor antibodies give you acquired hyperekplexia, whereas the mutations give you hereditary hyperekplexia. So, there is, indeed, a bit of an overlap between autoimmune and genetic disorders, but often, also, like, the age at onset (because that might be the next question, the age at onset), and maybe family history and associated features, should help to distinguish the two. I think more from the pathophysiological point interesting, rather than clinically too confusing. Dr Smith: Wow, that's really cool. So, another question I have is regarding antibody panels, right? And so, I think, oftentimes (at least around here), folks confronting an unusual phenotype will send the Mayo panel - they'll send autoimmune encephalitis or a paraneoplastic panel – and, you know, I think one of the challenges I have thinking about the spectrum of phenotypes that you described, I mean, if you recognize “Aunt Minnie”, then you know where to go, but it seems to me that there's a lot of these that maybe folks don't recognize “Aunt Minnie”. What is the diagnostic utility and pearls and pitfalls of ordering these panels when you're not really certain? In other words, is there a risk of a false positive if the pretest probability is low? So, I guess that's a long question, but do you have guidance about when we should and maybe when we should not be ordering these panels? So, you know, undifferentiated ataxia that's chronically progressive - should we be sending a panel or not? Patients who are later-onset acute, maybe so. So, what's the guidance on when to order the panel? Dr Balint: It's a tricky topic also for many people in our practice, because, of course, as you said, we don't want to miss something, but, indeed, with any test which you order with a low pretest probability and which is not quite appropriate, you might have false positives, and that might cause much additional trouble in security, or maybe unnecessary and invasive immunotherapy with adverse effects – so, it's really important to think well about antibody testing. And, generally speaking, like always in medicine, we shouldn't order random tests, and antibody panels and neuronal antibodies are not designed as a screening test, so you need to have a phenotype and a reasonable suspicion - and clinical acumen is really key, and that's why also the article is so much focused on the phenotype. It's clearly not that any movement disorder patient who enters the outpatient clinic should get a blood test for antibodies that will likely cause harm, and it has been shown that these antibodies can be falsely positive, both in other diseases but also in healthy controls, and much depends also on which tests you use (but, let's not go into too much detail over here) - so, generally speaking, I would say if you have a suspicion of an autoimmune disease clinically (I mentioned some scenarios where you would think of an autoimmune disorder). And then, ataxias are, of course, a bit tricky, because often, we don't have too many other handles there, and there's still also a significant number of acquired late-onset ataxia where we don't know what the cause is. I think in the ataxia scenario, if I don't have a good answer or explanation, I would order antibody tests a bit more freely - I mean, if you do it properly, you do the serum and the CSF, and that also increases your sensitivity but also the specificities, so I wouldn't then just do the serum, but then go for serum and CSF. In other movement disorders, it depends also a little bit on the phenotype. So, somebody with a phenotype fitting well with Parkinson's disease, I wouldn't do any testing. Somebody with clear PSP phenotype without any red flags or not-fitting features, it is very unlikely to have an antibody finding, and this has been shown also in cohorts. But, if you have something which is not fitting in the phenotypes - for example, you have somebody where you think it might be a PSP phenotype with predominantly axial Parkinsonism falls, but you notice that the oculomotor disturbance is not a vertical gaze palsy, but a horizontal gaze palsy – so, it's not really fitting phenotype as you know it. That's a scenario where would probably think of antibody testing. Then, if you do the testing theorem - and CSF, in general, is gold standard - there are some antibodies where theorem is good enough (like, for example, with aquaporin-4 antibodies), but the reason why we do serum and CSF, as I mentioned, is the increased sensitivity and specificity. And nowadays, in the antibody world, we have something similar to the genetics - we have the variant of unknown significance and in the neurology world, we coin the term “antibody of unknown significance” to also give a name to the problem that, sometimes, we get a test result and it is difficult to interpret. Another handle over there would be to try to confirm the test result in another test method. So for example, if you have a cell-based assay with an antibody finding, you would like to confirm that on immunohistochemistry - the staining pattern is in keeping with that. Dr Smith: So, Bettina, that was a really great and comprehensive answer to the question with a lot of pearls packed into it, and I think the idea that, you know, oftentimes, it's helpful to do both serum and CSF testing is important - also looking for staining to further confirm the diagnosis. And, I think one of the things that I was struck by in your response was the example of a PSP patient who instead of vertical gaze palsy had horizontal gaze palsy as a red flag, and I think a lot of our listeners are probably familiar with the idea that maybe hyperkinetic movement disorders might be autoimmune, or certainly rapidly progressive ataxia, but at least I don't think of Parkinsonian syndromes as often. I know there are some that we need to consider. Maybe you can give us some pearls about when we should consider antibody testing in a patient who has a Parkinson syndrome? Dr Balint: So, I will not cover now the paraneoplastic Parkinsonian syndromes (because they typically develop as rapidly that you would anyway think about it, hopefully), but go more into those conditions which might mimic degenerative disease - and one of the most interesting antibodies in this regard is IgLON5, and you will be aware that it has been discovered in 2014 in patients who shared a characteristic sleep movement disorder (non-REM parasomnia). The spectrum has broadened a lot, and one possible manifestation is that it could come into the differential of Parkinsonian syndromes - so, for example, if you have axial Parkinsonism and a gaze palsy, you are in a PSP phenotype, but the red flag would be maybe if the eye movement disorders are not really fitting with the PSP phenotype. Also, in PSP patients, we don't expect parasomnias at night. If the bed partner is, for example, complaining that the patient is moving in his sleep and doing movements, then this would be a red flag, and in this context, you would think of IgLON5. IgLON5 could also give you Parkinsonism and cerebellar ataxia, and they might have dysautonomia, and, of course, with a sleep movement disorder, you are now in the ballpark of MSA phenotypes; however, if there are additional features (like, for example, fasciculations) which you don't expect in MSA, that would be, again, the red flag. So, typically, even in those differentials, there are some red flags on handles which would point you to the diagnosis - it is not that it completely mimics the phenotype of our default degenerative disease, but, sometimes, you need to hunt a little bit for those handles. Dr Smith: So, Bettina, that's really interesting. I wanted to ask you about IgLON5, and in particular, the sleep phenotype, but, you know, I wonder whether there's a risk of just confusing this with REM sleep behavior disorder and a chronic Parkinsonian syndrome - what's the time course of this, and any other wisdom in terms of how to differentiate it from, you know, a more common neurodegenerative problem? Dr Balint: So, the spectrum of sleep disorders in IgLON5 is actually a bit broad. The characteristic thing is the non-REM sleep parasomnia with the finalistic fine movements, but classic REM sleep behavior disorder has also been reported in these patients. And one of the tricky things is IgLON5 is a slowly progressive disease (some patients had symptoms for a decade prior to diagnosis), so it's really an important differential of autoimmune disease - but as mentioned, the features not fitting in, and they are typically also the cardinal features. So, gaze palsies are very frequent, ptosis, bulbar symptoms, vocal cord palsy, sleep movement disorders which might not fit to the original phenotype, and breathing problems (for example) so severe that they require a tracheostoma – so, these are some red flags which would alert you to this diagnosis of anti-IgLON5 disease. Dr Smith: I'm curious, Bettina, how do you keep up on all of this and keep it all straight? Right, there's a lot of information, and as I was reading your article, you've got these wonderful tables - and in fact, this whole issue for our listeners feels that way. I've read several of these articles now, and I'm just curious what your strategy is to stay up to date and stay organized. You have to be very organized to be an autoimmune neurologist, it seems to me. Dr Balint: And having a little bit of OCD helps clearly, as always, in neurology. I think it is just that I started to be interested in this area for a while and I have in my head the clinical phenotype to most important associated antibodies, and as the field continues, I just add up on that panel. But, I don't want people to be discouraged - you're right, many antibodies, but I think the point is not to know each and every antibody but to know in which scenario to think of an autoimmune syndrome and then to know where to look it up. Dr Smith: Well, I think that's a great way of ending our conversation, Bettina. I think your article does a great job of that, and one of the things I love about Continuum is these articles serve as point-of-care tools. I think our conversation will also serve as a useful framework, because I think you've talked a lot about how to organize your thinking, and, you know, pearls for when we should be thinking about these disorders which are uncommon, but you certainly don't want to miss one because the therapy can be very effective. So, Bettina, thank you so much for joining me. This has been a really great conversation. Dr Balint: Thank you so much, Gordon. Thank you very much for your good questions. Dr Smith: So, again, today, I've had the great pleasure of interviewing Dr Bettina Balint, whose article on ataxia and other autoimmune movement disorders appears in the most recent issue of Continuum, which is on autoimmune neurology. Be sure to check out Continuum Audio episodes from this and other issues. And thanks to our listeners for joining us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at Continpub.com/AudioCME. Thank you for listening to Continuum Audio.

The Autophagy-Lysosomal Pathway and Development of Relevant PD Biomarkers with Zhenyu Yue

The Michael J. Fox Foundation Parkinson's Podcast

Play Episode Listen Later Aug 20, 2024 31:54

Though existing evidence supports that dysfunction in the clearing of cellular debris plays an important role in the development of Parkinson's disease, many unanswered questions remain regarding the mechanisms of the autophagy-lysosomal pathway involved in this process. In particular, research in the field has been limited by a lack of reliable, quantitative tests for monitoring autophagy-lysosome activity. In this interview, Dr. Zhenyu Yue describes his research investigating the cellular and molecular mechanisms for Parkinson's disease and other neurodegenerative diseases, focusing on their work examining the regulation of the autophagy-lysosomal pathway, potential therapeutic targets, and MJFF-funded research that aims to develop sensitive, robust autophagy-lysosome assays to facilitate the discovery of biomarkers for PD using stem cell-derived neurons and biofluids. Zhenyu is the Aidekman Research Professor in the Department of Neurology and Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. He is also the Director of the Center of Parkinson's Disease Neurobiology and Director of Basic Research of Movement Disorders at Mount Sinai.This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

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21: The Autophagy-Lysosomal Pathway and Development of Relevant PD Biomarkers with Zhenyu Yue

The Parkinsonâ€™s Research Podcast: New Discoveries in Neuroscience

Play Episode Listen Later Aug 20, 2024 31:54

Though existing evidence supports that dysfunction in the clearing of cellular debris plays an important role in the development of Parkinson's disease, many unanswered questions remain regarding the mechanisms of the autophagy-lysosomal pathway involved in this process. In particular, research in the field has been limited by a lack of reliable, quantitative tests for monitoring autophagy-lysosome activity. In this interview, Dr. Zhenyu Yue describes his research investigating the cellular and molecular mechanisms for Parkinson's disease and other neurodegenerative diseases, focusing on their work examining the regulation of the autophagy-lysosomal pathway, potential therapeutic targets, and MJFF-funded research that aims to develop sensitive, robust autophagy-lysosome assays to facilitate the discovery of biomarkers for PD using stem cell-derived neurons and biofluids. Zhenyu is the Aidekman Research Professor in the Department of Neurology and Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. He is also the Director of the Center of Parkinson's Disease Neurobiology and Director of Basic Research of Movement Disorders at Mount Sinai.This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

director development medicine parkinson relevant pathway pd neurology mount sinai biomarkers icahn school autophagy movement disorders basic research friedman brain institute

Promoting awareness of drug-induced movement disorders

The Capitol Pressroom

Play Episode Listen Later Aug 8, 2024 9:49

August 8, 2024 - Mental Health Association of New York State CEO Glenn Liebman talks about legislation addressing drug-induced movement disorders, which can be caused by older medications used to treat severe mental health conditions.

drug promoting induced movement disorders mental health association

Movement Disorders Emergencies - Part 3

Play Episode Listen Later Aug 7, 2024 2:40

In the last episode of this three-part series, Dr. Jeff Ratliff discusses how to approach patients presenting with emergent rigidity and difficulty moving.

journal pd neurology emergencies movement disorders jeff ratliff

Movement Disorders Emergencies - Part 2

Play Episode Listen Later Aug 6, 2024 3:48

In the second episode of this three-part series, Dr. Jeff Ratliff provides a rapid overview of hyperkinetic disorders that require urgent attention.

journal pd neurology emergencies movement disorders jeff ratliff

Movement Disorders Emergencies - Part 1

Play Episode Listen Later Aug 5, 2024 3:00

In the first episode of this three-part series, Dr. Jeff Ratliff discusses a few key points to help recognize and initiate treatment for patients with movement disorder emergencies, focusing on the initial approach to these disorders. It is important to consider medications, labs, and imaging as part of the evaluation process.

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Do subjective cognitive complaints predict future incident cognitive impairment in people with Parkinson's disease?

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Play Episode Listen Later Jul 8, 2024

Dr. Eduardo Fernández and Dr. Daniel Weintraub discuss whether subjective cognitive complaints can predict future incident cognitive impairment and other questions related to early cognitive impairment in people with Parkinson's disease, referencing Dr. Weintraub's recent article, "Association between subjective cognitive complaints and incident functional impairment in Parkinson's disease" published in Movement Disorders. Read article »

Managing Movement Disorders ACPE-Accredited

CorConsult Rx: Evidence-Based Medicine and Pharmacy

Play Episode Listen Later Jun 19, 2024 62:36

On this episode, we discuss the management of a few different movement disorders. We review the pharmacotherapy options for restless leg syndrome, Tourette's syndrome, and tardive dyskinesea. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. For existing Unlimited (Gold) freeCE members, this CE option is included in your membership benefits at no additional cost! A password, which will be given at some point during this episode, is required to access the post-activity test. To earn credit for this episode, visit the following link below to go to freeCE's website: https://www.freece.com/ If you're not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their website and earn CE for listening to this podcast. Thanks for listening! We want to give a big thanks to our sponsor, High-Powered Medicine. HPM is a book/website database of summaries for over 150 landmark clinical trials. You can get a copy of HPM, written by Dr. Alex Poppen, PharmD, at the links below: Purchase a subscription or PDF copy - https://highpoweredmedicine.com/ Purchase the paperback and hardcover - Barnes and Noble website We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below: www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com Instagram and other social media platforms - @corconsultrx This podcast reviews current evidence-based medicine and pharmacy treatment options. This podcast is intended to be used for educational purposes only and is intended for healthcare professionals and students. This podcast is not for patients and not intended as advice or treatment.

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Hot Topic: Limitations of phenomenology in functional movement disorders: what can we learn?

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Play Episode Listen Later Jun 17, 2024

In this Hot Topic, Dr. Sarah Lidstone moderates a discussion with Dr. Mark Hallett and Prof. Mark Edwards on the limitations of phenomenology in movement disorders. Drawn from a recent viewpoint by Prof. Edwards and using functional movement disorder as an example, they discuss the benefits and drawbacks of a phenotype equaling disease paradigm, the voluntary vs. involuntary movement disorder, and what we can learn from functional movement disorders.

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TdC 236: Magnésio - 4 Clinicagens

Ta de Clinicagem

Play Episode Listen Later May 29, 2024 35:03

Pedro Magno, Luisa Sousa e Caio Bastos falam de 4 clinicagens sobre magnésio: 1. Como investigar hipomagnesemia? 2. Magnésio e outros eletrólitos 3. Quando repor? 4. Como repor? Referências: 1. Zipursky, Jonathan et al. “Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case-control study.” PLoS medicine vol. 11,9 e1001736. 30 Sep. 2014, doi:10.1371/journal.pmed.1001736 2. Cheungpasitporn, Wisit et al. “Hospital-Acquired Dysmagnesemia and In-Hospital Mortality.” Medical sciences (Basel, Switzerland) vol. 8,3 37. 1 Sep. 2020, doi:10.3390/medsci8030037 3. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. Lancet. 1995;345(8951):669-685. 4. Magnesium in Coronaries (MAGIC) Trial Investigators. Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet. 2002;360(9341):1189-1196. doi:10.1016/s0140-6736(02)11278-5 5. Ray S, Park KW. Movement Disorders and Other Neurologic Impairment Associated With Hypomagnesemia: A Systematic Review. Neurol Clin Pract. 2023;13(6):e200202. doi:10.1212/CPJ.0000000000200202 6. De las Peñas R, Escobar Y, Henao F, Blasco A, Rodríguez CA; Spanish Society for Medical Oncology. SEOM guidelines on hydroelectrolytic disorders. Clin Transl Oncol. 2014;16(12):1051-1059. doi:10.1007/s12094-014-1234-2 7. Spichler A, Athanazio DA, Furtado J, Seguro A, Vinetz JM. Case report: severe, symptomatic hypomagnesemia in acute leptospirosis. Am J Trop Med Hyg. 2008;79(6):915-917. 8. Porath A, Mosseri M, Harman I, Ovsyshcher I, Keynan A. Dead Sea water poisoning. Ann Emerg Med. 1989;18(2):187-191. doi:10.1016/s0196-0644(89)80112-x 9. Wacker WE, Parisi AF. Magnesium metabolism. N Engl J Med. 1968;278(12):658-663. doi:10.1056/NEJM196803212781205

Innovative Fellowship Program is Training Tomorrow's Parkinson's Leaders with Rachel Dolhun

The Michael J. Fox Foundation Parkinson's Podcast

Play Episode Listen Later May 21, 2024 40:10

Demand for movement disorder specialists continues to grow, but not enough neurologists are receiving focused training in Parkinson's and related conditions in order to meet the current and projected needs in the U.S. and around the world. In collaboration with longtime partner the Edmond J. Safra Foundation, The Michael J. Fox Foundation created the Edmond J. Safra Fellowship in Movement Disorders with the goal of growing the global base of movement disorders specialists. In this episode Dr. Rachel Dolhun shares more about this fellowship program, the application process, and how the program supports the training of movement disorders clinician-researchers who will become leaders in Parkinson's care and advance science in the field. Rachel is Senior Vice President of Medical Communications at The Michael J. Fox Foundation for Parkinson's Research. Visit michaeljfox.org/funding to learn more about the Edmond J. Safra Fellowship in Movement Disorders. This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

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15: Innovative Fellowship Program is Training Tomorrow's Parkinson's Leaders with Rachel Dolhun

The Parkinsonâ€™s Research Podcast: New Discoveries in Neuroscience

Play Episode Listen Later May 21, 2024 40:10

Demand for movement disorder specialists continues to grow, but not enough neurologists are receiving focused training in Parkinson's and related conditions in order to meet the current and projected needs in the U.S. and around the world. In collaboration with longtime partner the Edmond J. Safra Foundation, The Michael J. Fox Foundation created the Edmond J. Safra Fellowship in Movement Disorders with the goal of growing the global base of movement disorders specialists. In this episode Dr. Rachel Dolhun shares more about this fellowship program, the application process, and how the program supports the training of movement disorders clinician-researchers who will become leaders in Parkinson's care and advance science in the field. Rachel is Senior Vice President of Medical Communications at The Michael J. Fox Foundation for Parkinson's Research. Visit michaeljfox.org/funding to learn more about the Edmond J. Safra Fellowship in Movement Disorders. This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

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Hot Topic: Focused Ultrasound in Movement Disorders - Brain ablations as a therapeutic tool

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Play Episode Listen Later May 13, 2024

In this Hot Topic episode, Dr. Michele Matarazzo interviews Dr. Raul Martinez on the recent evidence and future applications of focused ultrasound-based ablations in movement disorders, such as Parkinson's disease and essential tremors. Discover how this innovative approach is improving patient care and what it could mean for the future of medical treatment.

Life After a Parkinson's Diagnosis

Baptist HealthTalk

Play Episode Listen Later Apr 17, 2024 20:59

Award-winning actor Michael J. Fox was diagnosed with Parkinson's disease in 1991 at just 29 years of age. It's a progressive brain disorder that can strip away a person's movement and speech over time. There's been some headway since Mr. Fox created his foundation on Parkinson's research in 2000. But what's the latest and what more can be done for the estimated one million Americans who have this disease? Host: David Jeannot Guests: Diego Torres-Russotto, M.D., Chief of Movement Disorders at Baptist Health Miami Neuroscience Institute Ana Velasco, Parkinson's Patient

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BrainWaves #126 HD part 1: Differential diagnosis and clinical features

MedLink Neurology Podcast

Play Episode Listen Later Apr 9, 2024 29:07

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: December 6, 2018 You may be able to recognize chorea. But what does it make you think of besides Huntington disease? In this two-part series, we'll cover the clinical manifestations, differential diagnosis, and management of Huntington disease. In part 1, Dr. Travis Lewis (University of Pennsylvania) creates a framework for hyperkinetic movement disorders and Huntington disease. Part 2 will focus on the current and future therapeutics of this neurodegenerative condition. Produced by Travis Lewis and James E Siegler. Music by Azevedo Silva, Chris Zabriskie, Cullah, John Bartmann, and Nuno Adelaida. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Bates GP, Dorsey R, Gusella JF, et al. Huntington disease. Nat Rev Dis Primers 2015;1:15005. PMID 27188817Ghosh R, Tabrizi SJ. Huntington disease. Handb Clin Neurol 2018;147:255-78. PMID 29325616Reilmann R, Leavitt BR, Ross CA. Diagnostic criteria for Huntington's disease based on natural history. Mov Disord 2014;29(11):1335-41. PMID 25164527Walker RH. Chorea. Continuum (Minneap Minn) 2013;19(5 Movement Disorders):1242-63. PMID 24092289Wild EJ, Tabrizi SJ. The differential diagnosis of chorea. Pract Neurol 2007;7(6):360-73. PMID 18024776 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

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IM Board Prep #6: Movement Disorders

The Neurotransmitters

Play Episode Listen Later Apr 8, 2024 30:33 Transcription Available

Welcome back to our IM Board Prep series, that is designed to help internal medicine residents ace the neurology section of their board exams! This episode is on movement disorders, categorized into hyperkinetic and hypokinetic. In hypokinetic, we cover Parkinsonism vs Parkinson's disease vs “Parkinson's plus” syndromes. In hyperkinetic, we focus on tremors, dystonia, choreiform disorders, myoclonus, sleep-related disorders, tardive dyskinesia and neuroleptic malignant syndrome. Check out our website at www.theneurotransmitters.com to sign up for emails, classes, and quizzes! Would you like to be a guest or suggest a topic? Email us at contact@theneurotransmitters.com Follow our podcast channel for The Neurotransmitters @neuro_podcast for future news! Find me on Twitter @DrKentris (https://twitter.com/DrKentris) The views expressed do not necessarily represent those of any associated organizations. The information in this podcast is for educational and informational purposes only and does not represent specific medical/health advice. Please consult with an appropriate health care professional for any medical/health advice.

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Special Episode: The wisdom of our mentors: clinical pearls in movement disorders

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Play Episode Listen Later Mar 25, 2024

In this episode, Dr. Hugo Morales interviews Dr. Bas Bloem and Dr. Victor Fung, co-authors of "The Wisdom of Our Mentors: Clinical Pearls in Movement Disorders," who share clinical pearls and discuss how mentors' and mentees' interactions are at the center of mentorship in movement disorders and the MDS. Read the article

Hot Topic: Focused Ultrasound in Movement Disorders - Blood-Brain Barrier Opening

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Play Episode Listen Later Mar 18, 2024

In this Hot Topic episode, Dr. Michele Matarazzo interviews Dr. Nir Lipsman on the Focused Ultrasound-mediated Blood-Brain Barrier Opening, from technical challenges to current evidence and future perspective of this promising technology that could provide a new way to deliver drugs in the brain.

High-Tech Brain Implants for Parkinson's: A Patient + Neurologist on Neuromodulation

Brain Talk | Being Patient for Alzheimer's & dementia patients & caregivers

Play Episode Listen Later Mar 18, 2024 43:43

High-tech treatments for neurodegenerative diseases are on the horizon. In fact, some patients already have brain implants that help address their symptoms through “reprogramming the brain.” Hear from one patient and his doctor about the real-life story behind this innovative new treatment for Parkinson's. Speaker, author, and Parkinson's Disease advocate Benjamin Stecher and neurologist Dr. Alfonso Fasano, join Being Patient live talks to discuss their upcoming book on just this topic, Reprogramming the Brain. The upcoming book, traces the experience of Stecher and his doctor Fasano's 2021 decision to surgically implant two six-inch-long metal alloy spikes all the way through his brain. With the patient and doctor writing about the experience and what was to come afterward, the upcoming book will serve as a guide for the future of the brain and neuromodulation. Stecher, who was diagnosed with Parkinson's disease at age 29, speaks regularly at academic centers and biotech companies about neurodegenerative diseases, research advocacy, and healthcare. The founder of Tomorrow Edition, he is a patient advisor to several organizations, including the Toronto Western Hospital Movement Disorder Clinic and Rune Labs. In addition to his upcoming book, he also co-wrote Brain Fables with Alberto Espay, published by Cambridge University Press. Fasano, who holds the Chair in Neuromodulation at the University of Toronto and University Health Network, is also a Professor in the Department of Medicine at the University of Toronto. In addition, he is staff neurologist and co-director of the Surgical Program for Movement Disorders at Toronto Western Hospital, staff neurologist at the Hospital of Sick Children in Toronto, and clinician investigator at the Krembil Research Institute and KITE – Toronto Rehabilitation Hospital. His work focuses on the treatment of movement disorders with advanced technology, pathophysiology, and treatment of tremor and gait disorders.

Hot Topic: Focused Ultrasound in Movement Disorders - Neuromodulation

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Play Episode Listen Later Mar 4, 2024

Dr. Michele Matarazzo interviews Dr. Robert Chen about the rapidly expanding applications of focused ultrasound-based neuromodulation in neurology, particularly in movement disorders, from tremor to Parkinson's disease. Tune in to uncover the future and potential of non-invasive neurotherapies that are setting new standards in research and patient care.

Redefining Parkinson's Disease | Kathleen Poston

From Our Neurons to Yours

Play Episode Play 30 sec Highlight Listen Later Feb 29, 2024 24:28 Transcription Available

Today on the show, a new understanding of Parkinson's disease. Parkinson's disease is one of the most common neurodegenerative disorders — right after Alzheimer's disease. It's familiar to many as a movement disorder: people with the disease develop difficulties with voluntary control of their bodies. But the real story is much more complicated.This week, we speak with Kathleen Poston, a Stanford neurologist who is at the forefront of efforts to redefine Parkinson's disease and related disorders based on their underlying biology — not just their symptoms. As Poston says: "The biology is the disease." Join us to learn about exciting advances in our ability to detect the brain pathology driving these disorders much earlier, even before symptoms arise, and how this is opening doors for early intervention and — hopefully — prevention.Learn MorePoston Lab at Stanford MedicineLewy Body Dementia Research Center of Excellence at StanfordUnderstanding Parkinson's Disease: Stanford's Dr. Kathleen Poston on latest advances (CBS News Bay Area - Video)A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research (The Lancet - Neurology, 2024)International Working Group Proposes New Framework for Defining Parkinson Disease Based on Biology, Not Symptoms (Neurology Live article)Episode CreditsThis episode was produced by Michael Osborne at 14th Street Studios, with production assistance by Morgan Honaker. Our logo is by Aimee Garza. The show is hosted by Nicholas Weiler at Stanford's Wu Tsai Neurosciences Institute and Knight Initiative for Brain Resilience. Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

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Movement disorders and mRNA therapy in Arginosuccinic aciduria

JIMD Podcasts

Play Episode Listen Later Feb 2, 2024 24:44

Dr Sonam Gurung and Dr Julien Baruteau discuss movement disorders in Arginosuccinic aciduria and explain how recent work with mRNA therapy shows potential as a treatment in this condition. The incidence of movement disorder increases with age and contrasts with subtle and limited neuroimaging abnormalities in argininosuccinic aciduria Gurung et al https://doi.org/10.1002/jimd.12691 mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria Gurung et al https://doi.org/10.1126/scitranslmed.adh1334

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123 Seizures & Cognitive Disorders – Last episode of 2023

Physician Assistant Exam Review

Play Episode Listen Later Dec 19, 2023 36:54

Grab your Neuro Rapid Review Questions Grab your Neuro Rapid Review Questions More Neuro for the PANCE 122 Peripheral Nerve Disorders & how to keep getting better at what you do 121 Movement Disorders – Best episode ever 120 Movement Disorders 119 Headaches – Get These Right! 118: Brain Trauma & Memorizing Medication tip The post 123 Seizures & Cognitive Disorders – Last episode of 2023 appeared first on Physician Assistant Exam Review.

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Work Life and Wellness: Navigating Family Health Issues

Neurology Nuts and Bolts: Constructing Your Career

Play Episode Listen Later Dec 19, 2023 40:42

Sagari Betté discusses navigating unexpected family health issues with Sara Schaefer, Assistant Professor of Neurology at Yale and founder of this podcast, and Kathrin LaFaver, Movement Disorders and Lifestyle Medicine Neurologist in Saratoga Springs, NY. They discuss the evolution of health concerns in their own family members, how that acutely and chronically altered their career trajectories, what they learned about the patient and caregiver perspective in medicine, and how it contributes to the way that they approach patient care.

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121 Movement Disorders – Best episode ever

Physician Assistant Exam Review

Play Episode Listen Later Nov 15, 2023 35:38

www.physicianassistantexamreview.com/blackfriday to find out more about getting in on the 75% off deal Click here to get the active study guide for movement disorders – It’s amazing! Essential Tremor Clinical Presentation Labs, Studies, and Physical Exam Findings Treatment Huntington's Disease Clinical Presentation Labs, Studies, and Physical Exam Findings Treatment Parkinson's Disease Clinical Presentation Labs, Studies, […] The post 121 Movement Disorders – Best episode ever appeared first on Physician Assistant Exam Review.

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120 Movement Disorders

Physician Assistant Exam Review

Play Episode Listen Later Oct 24, 2023 20:52

I created an Active Study Guide for this episode with Sticky Stories, PANCE questoins and more. Click here to get it. Cerebral Palsy Risk Factors Clinical Presentation Labs, Studies, and Physical Exam Findings Treatment Differential Diagnosis Multiple Sclerosis (MS) Risk Factors Clinical Presentation Labs, Studies, and Physical Exam Findings Treatment Options Differential Diagnosis Myasthenia Gravis […] The post 120 Movement Disorders appeared first on Physician Assistant Exam Review.

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Eye Movements to Diagnose Movement Disorders - Part 5

Play Episode Listen Later Oct 17, 2023 3:12

Dr. Jeff Ratliff concludes his series on how to use eye movements in evaluations of patients with movement disorders.

Eye Movements to Diagnose Movement Disorders - Part 4

Play Episode Listen Later Oct 16, 2023 1:58

Dr. Jeff Ratliff continues his series on how to use eye movements in evaluations of patients with movement disorders.

Eye Movements to Diagnose Movement Disorders - Part 3

Play Episode Listen Later Oct 12, 2023 3:36

Dr. Jeff Ratliff continues his series on how to use eye movements in evaluations of patients with movement disorders.

Eye Movements to Diagnose Movement Disorders - Part 2

Play Episode Listen Later Oct 10, 2023 2:26

Dr. Jeff Ratliff continues his series on how to use eye movements in evaluations of patients with movement disorders.

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

729: Studying Synaptic Plasticity to Understand How the Brain Learns and Adapts - Dr. Nicole Calakos

Play Episode Listen Later Oct 9, 2023 44:06

Dr. Nicole Calakos is the Lincoln Financial Group Distinguished Professor of Neurobiology and Chief of the Movement Disorders section in Neurology at Duke University Medical Center. Research in Nicole's lab examines how the brain learns and adapts to experiences. She studies synaptic plasticity, from the levels of molecules, cells, cell circuits, and behaviors, to understand what goes wrong in disease and how we can harness brain processes to address disease. When she's not working, Nicole enjoys being outdoors, playing sports, running, going mountain biking, and participating in mountain bike races. Her favorite indoor activities include creative cooking and spending time with family and friends. Nicole was awarded her MD and PhD degrees from Stanford University. Afterwards, she completed an internship in Medicine and Residency in Neurology at the University of California, San Francisco School of Medicine. She conducted postdoctoral research at Stanford University before joining the faculty at Duke University in 2005. Nicole has received numerous awards and honors in her career, including the 2023 Korsmeyer award from the American Society of Clinical Investigation and being named an elected Member of the U.S. National Academy of Medicine, a Fellow of the American Association for the Advancement of Science, and a Fellow of the American Society of Clinical Investigators. In our interview, Nicole shares more about her life and science.

Eye Movements to Diagnose Movement Disorders - Part 1

Play Episode Listen Later Oct 9, 2023 2:56

Dr. Jeff Ratliff begins a series on how to use eye movements in evaluations of patients with movement disorders. Show references: https://neurologyminute.libsyn.com/website/examining-eye-movements