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Eugene Khayman, co-founder of Million Dollar Sellers (MDS), who leads the "Gimme Five" campaign aimed at pushing Amazon to give sellers some fee relief after years of rising costs. Thinking about taking some risk off the table? Or are you looking at taking an extended break from e-commerce in general? Know what your e-commerce business is worth with Quiet Light Brokerage. The gap between paying for inventory and selling it is where stockouts are born. Onramp Funds closes it with funding that moves with your sales. Built for sellers already doing $10K a month or more across Amazon, Walmart, Shopify, and TikTok Shop. See how much you qualify for at Onramp Funds. With changes to DD+7, Subscribe and Save, and the additional seller fees tacked on this year, third-party sellers on Amazon are quickly discovering that it might be more profitable to take their products elsewhere. And Amazon has noticed. Eugene also talks about what he's noticed after years of being in MDS, like the shifts toward DTC and Tiktok Shop and how smaller operators have been the most creative in growing their business. Timestamps 00:00 - Introduction 00:58 - Eugene Kaiman and the MDS seller community 06:34 - Eugene's 15-year e-commerce path from sneakers to brands 09:39 - Why MDS became a seller advocacy hub 10:09 - What the Gimme Five campaign is asking Amazon to do 11:31 - How SOS campaigns formed in response to fee pressure and policy changes 13:28 - Survey data: 52 cents of every dollar goes to Amazon fees 14:42 - Does Amazon actually have room to give some margin back? 16:16 - When fees make sense versus when they feel punitive 18:25 - Why higher fees can also hurt customer value and price competitiveness 20:25 - Which fee changes could realistically help sellers 22:43 - The Subscribe and Save top-up change and why it matters 23:32 - Return fees, removals, and launch risk 24:02 - MDS data: launches needed for growth have doubled 25:48 - Fees are only acceptable if growth is keeping pace 27:23 - Rising risk from competitor attacks, faster cloning, and shorter product life cycle 30:54 - Why many sellers are rethinking Amazon as their top channel 33:00 - The problem of not knowing the true cost to sell on Amazon 34:51 - Two asks for Amazon: centralized communication and a centralized fee committee 36:12 - DD plus 7, account reserves, and the hidden bookkeeping cost 38:59 - What MDS is, how big it has become, and where it's headed 42:57 - Why smaller operators often spot the best new growth ideas 43:27 - The rise of authority affiliates and in-person selling networks 46:37 - TikTok's promise, limits, and how DTC is becoming more predictable 48:19 - MDS, Millie, and the community's newest tools Eugene, thanks for coming on the podcast. If you'd like to support Eugene and the Gimme Five campaign, here's a link to the X post. If you'd like to find out more about MDS, you can book a free call here! As always, if you have any questions or anything that you need help with, leave a comment down below if you're interested. Don't forget to leave us a review on iTunes if you enjoy our content. Thanks for listening! Until next time, happy selling!
MDs react to JAMA op-ed claiming autonomous AI will outperform doctors on routine medical tasks by 2030, spurring widespread layoffs: When even intravenous iron isn't enough to stave off anemia; “Emergency “ home medical kits draw ire of medical experts: Meta dinged $567 for teen addiction—why spending it for therapy of adolescents who are hooked on social media may be a waste of money; Adequate vitamin D minimizes post-op pain; When is a second prostate biopsy called for?
At the 2026 Society of Hematologic Oncology (SOHO) Annual Meeting, CancerNetwork® sat down with a variety of experts to discuss the latest data and emerging trends surrounding the management of different hematologic malignancies. Speakers and presentations covered everything from second primary malignancy risks to novel clinical trial findings across lymphoma, myelodysplastic syndrome (MDS), leukemia, and other patient patients.First, Jasmine M, Zain, MD, an attending physician in the Lymphoma Service at Memorial Sloan Kettering Cancer Center, highlighted key takeaways from her presentation exploring the risk of secondary lymphoma malignancies following CAR T-cell therapy. In addition to discussing the incidence, mechanisms, and possible risk factors of these second malignancies, she detailed how to clinically differentiate between malignancies directly driven by retroviral or lentiviral insertional mutagenesis compared with those arising from cumulative genotoxic stress.Additionally, David Sallman, MD, an associate member in the Department of Malignant Hematology at Moffitt Cancer Center in Tampa, Florida, reviewed findings from the phase 2a HT-6184-MDS-001 trial (NCT07052006). In this study, Sallman and colleagues assessed ofirnoflast (HT-6184), a first-in-class oral allosteric NEK7 inhibitor designed to block NLRP3 inflammasome activation, in patients with lower-risk MDS who were refractory to, intolerant of, or ineligible for erythropoiesis-stimulating agents. Sallman discussed the platelet and neutrophil responses observed with ofirnoflast and how its intermittent, oral dosing schedule may protect long-term quality of life, especially among older patients with comorbidities.Finally, Julie M. Vose, MD, MBA, the George and Peggy Payne Distinguished Chair of Oncology, professor in the Division of Hematology, and director of the Lymphoma Research Group at the University of Nebraska Medical Center, and co–editor in chief of ONCOLOGY®, spoke about general developments relating to the ever-evolving chronic lymphocytic leukemia (CLL) field. She detailed how minimal residual disease (MRD) testing may serve as an informative clinical decision-making tool, outlined strategies for community practices to keep up to date with the latest happenings in the space, and identified time-limited therapies as a key theme from the meeting.References Zain JM. Understanding the risk of second malignancies after CAR T therapies. Presented at: Society of Hematologic Oncology Annual Meeting; September 9-12, 2026; Houston, TX. Sallman D, Bafna V, Nath UK, et al. Ofirnoflast (HT-6184), a first-in-class allosteric NEK7 inhibitor, achieves durable transfusion independence (TI) and hematological improvement-erythroid (HI-E) in ESA-refractory lower-risk myelodysplastic syndrome (LR-MDS): phase 2 final results. Presented at: 2026 SOHO Annual Meeting; September 9-12, 2026; Houston, TX.
For years, Harvard professor ERAM ALAM has been looking at the role immigrant physicians play in US healthcare. We fill a chronic shortage of new domestic MDs with doctors trained elsewhere. Nearly a quarter of our physicians went to medical school outside the U.S. or Canada . We talk about her book, THE CARE OF FOREIGNERS: How Immigrant Physicians Changed US Healthcare. I feel this is one of those issues where too many of us either don't recognize its existence or don't realize its implications. You can learn more at eramalam.com
A brand is more than some people think, but simpler than a lot of people think, all at the same time. It's way more than a logo, but boils down to a promise you make to your patients. Problem is, so many practices think it's more and miss the simplicity. Ashley Gay is the founder of Digital Ash Agency, a boutique healthcare branding firm that helps physicians launch and grow independent practices. With 25 years in branding and design, she built her husband's oculofacial plastic surgery practice under an 18-month noncompete — hitting $1 million in billables and 261 referring physicians in year one. She now works exclusively with MDs and DOs, building brands, websites, and patient acquisition systems for practices that want to stay independent. In this episode Carl White and Ashley Gay discuss: Why brand is so misunderstood amongst practice owners What state she finds brands in when she first works with clients What really goes into a brand and what does not Want to be a guest on PracticeCare®? Have an experience with a business issue you think others will benefit from? Come on PracticeCare® and tell the world! Here's the link where you can get the process started. Connect with Ashley Gay @md.brand.pro on Insta and TikTok Connect with Carl White Website: http://www.marketvisorygroup.com Email: whitec@marketvisorygroup.com Facebook: https://www.facebook.com/marketvisorygroup YouTube: https://www.youtube.com/channel/UCD9BLCu_i2ezBj1ktUHVmig LinkedIn: http://www.linkedin.com/in/healthcaremktg
Every field needs research. It's how we test ideas, see if our guesses were correct and prove that something actually works. In the world of oral ties, research is slow going, and desperately needed. Dr Lam-Do is working as part of a collaborative group with other release providers worldwide to study frenectomy after care. This study hopes to give us more information about what is necessary, what doesn't help and how we can support wound healing and function post release. Listen to hear more from Dr Lam-Do and Katie Oshita as they discuss the importance of research, timing of release, functional assessments and more.Podcast Guest: Dr. Lam-Do is one of the few dentists in Montreal, Canada accredited by the ALD (Academy of Laser Dentistry), he is a Fellow of the AGD (Academy of General Dentistry), a Fellow of the ALSC (American Laser Study Club), and a Fellow of the ICD (International College of Dentists). He is a graduate of The Breathe Institute and of AADSM's Mastery program (American Academy of Dental Sleep Medicine). He works with MDs, RNs, IBCLCs, SLPs, chiropractors, and osteopaths to help ankyloglossia patients of all ages. In 2019, he founded the Montreal Tongue-Tie Institute alongside his spouse Dr. Sochea Da Lung-Tor who is a general dentist with a focus on interceptive orthodontics and oromyofunctional therapy.Podcast Host: Katie Oshita, RN, BSN, IBCLC has over 25 years of experience working in Maternal-Infant Medicine. While Katie sees clients locally in western WA, Katie is also a telehealth lactation consultant believing that clients anywhere in the world deserve the best care possible for their needs. Being an expert on TOTs, Katie helps families everywhere navigate breastfeeding struggles, especially when related to tongue tie or low supply. Katie is also passionate about finding the root cause of symptoms, using Functional Medicine practices to help client not just survive, but truly thrive. Email katie@cuddlesandmilk.com or www.cuddlesandmilk.comSupport the show
Join the 12th Annual Trash the Dress for MDS in St. Olaf, Minnesota — a lively fundraiser featuring a 60-mile ATV/side-by-side ride, motorcycle and car groups, auctions, raffles (including a 2027 Polaris Ranger), mud pits, and family-friendly activities. Proceeds benefit Trails to Treatments and the Taylor Mohn MDS Research Fund. Registration is $25 per person and includes breakfast, lunch and door prizes. The event starts at Broadway Station with group photos, wheels rolling at 11 AM, lunch on route, silent and live auctions, and camping available. Follow the Facebook page or call 218-686-5827 for details.
Nvidia rachète Hugging Face, la plateforme d'origine française (3 co-fondateurs
How do you successfully transition into leading a highly regulated, technical industry like aviation with zero sector experience? In this wide-ranging and deeply personal episode, host Andy Lopata is joined by Charlie Whyman, Managing Director of aviation consultancy TGIS Aviation, to explore the reality of non-traditional leadership. Charlie shares how she used pure curiosity and relationship-building to navigate the complex world of engine asset management and convinced her co-owners to pivot their entire business strategy. She opens up about the realities of being a female leader in a male-dominated field, her late discovery of neurodivergence, and the "courage to be disliked." Charlie also shares a vulnerable, firsthand account of a professional character assassination, revealing how a call to a trusted friend in her personal network helped her identify her core values of fairness and justice. From workplace "love languages" to managing the balance of "Rock Stars" and "Superstars," this episode is a true masterclass in relational leadership. About Our Guest:Charlie Whyman helps highly capable people close the gap between knowing and doing by getting honest about the fear that keeps them stuck. An engineer by background, a sales and marketing expert by accident, and a Managing Director by invitation, Charlie has spent nearly two decades conducting live experiments in what fear actually does to capable people, and what it takes to move forward anyway. As one of the few female MDs in the aviation sector, Charlie's frameworks—including Clear the AIR™ (Avoid, Ignore, React) and the OTTER Framework™—help technical specialists, engineers, founders, and leaders build momentum and challenge the core myth of personal development: that you need confidence before you can act. What we Discussed In This Episode: The Zero-Experience Jump: How Charlie approached her transition into managing an aviation business by securing dedicated time with the owners and using networking events to listen, learn, and ask questions. The Curiosity Approach to Sales: Why natural curiosity and a desire to learn, build deeper trust and generate more business than traditional, aggressive sales tactics. Code-Switching and Embracing Difference: Charlie's 25-year history in male-dominated fields and how she stopped trying to blend in and started using her differences as a memorable asset. Leveraging Your Personal Network: The vital role that personal relationships play in professional life. The User Guide to Leadership: Charlie's practical tool for her team—How to Work with Charlie Without Losing Your Mind—and how she navigates difficult conversations. Workplace Love Languages: Understanding how different team members psychologically give and receive praise, and why leaders must match those individual needs. Rock Stars vs. Superstars: Applying Kim Scott's framework to manage the balance between stable, execution-focused "Rock Stars" (who do not want promotions) and high-ambition, opportunity-seeking "Superstars." Resources Mentioned in this Episode: Charlie's Frameworks: Clear the AIR™ (Avoiding, Ignoring, Reacting) and the OTTER Framework™ Book Mentioned: Nobody Believes You: Become a Leader People Will Follow by Jenny Field (Referencing the concept of being "likable, not liked") Book Mentioned: Radical Candor by Kim Scott (Referencing "Rock Stars" vs. "Superstars") Connect with Andy Lopata: Website | Instagram | LinkedIn | X/Twitter | YouTube Connect with Charlie Whyman: Website |LinkedIn | The Financial Times Guide to Mentoring
How do you successfully transition into leading a highly regulated, technical industry like aviation with zero sector experience? In this wide-ranging and deeply personal episode, host Andy Lopata is joined by Charlie Whyman, Managing Director of aviation consultancy TGIS Aviation, to explore the reality of non-traditional leadership. Charlie shares how she used pure curiosity and relationship-building to navigate the complex world of engine asset management and convinced her co-owners to pivot their entire business strategy. She opens up about the realities of being a female leader in a male-dominated field, her late discovery of neurodivergence, and the "courage to be disliked." Charlie also shares a vulnerable, firsthand account of a professional character assassination, revealing how a call to a trusted friend in her personal network helped her identify her core values of fairness and justice. From workplace "love languages" to managing the balance of "Rock Stars" and "Superstars," this episode is a true masterclass in relational leadership. About Our Guest:Charlie Whyman helps highly capable people close the gap between knowing and doing by getting honest about the fear that keeps them stuck. An engineer by background, a sales and marketing expert by accident, and a Managing Director by invitation, Charlie has spent nearly two decades conducting live experiments in what fear actually does to capable people, and what it takes to move forward anyway. As one of the few female MDs in the aviation sector, Charlie's frameworks—including Clear the AIR™ (Avoid, Ignore, React) and the OTTER Framework™—help technical specialists, engineers, founders, and leaders build momentum and challenge the core myth of personal development: that you need confidence before you can act. What we Discussed In This Episode: The Zero-Experience Jump: How Charlie approached her transition into managing an aviation business by securing dedicated time with the owners and using networking events to listen, learn, and ask questions. The Curiosity Approach to Sales: Why natural curiosity and a desire to learn, build deeper trust and generate more business than traditional, aggressive sales tactics. Code-Switching and Embracing Difference: Charlie's 25-year history in male-dominated fields and how she stopped trying to blend in and started using her differences as a memorable asset. Leveraging Your Personal Network: The vital role that personal relationships play in professional life. The User Guide to Leadership: Charlie's practical tool for her team—How to Work with Charlie Without Losing Your Mind—and how she navigates difficult conversations. Workplace Love Languages: Understanding how different team members psychologically give and receive praise, and why leaders must match those individual needs. Rock Stars vs. Superstars: Applying Kim Scott's framework to manage the balance between stable, execution-focused "Rock Stars" (who do not want promotions) and high-ambition, opportunity-seeking "Superstars." Resources Mentioned in this Episode: Charlie's Frameworks: Clear the AIR™ (Avoiding, Ignoring, Reacting) and the OTTER Framework™ Book Mentioned: Nobody Believes You: Become a Leader People Will Follow by Jenny Field (Referencing the concept of being "likable, not liked") Book Mentioned: Radical Candor by Kim Scott (Referencing "Rock Stars" vs. "Superstars") Connect with Andy Lopata: Website | Instagram | LinkedIn | X/Twitter | YouTube Connect with Charlie Whyman: Website |LinkedIn | The Financial Times Guide to Mentoring
Boeing, boing, boing, sliiiide, aaaannnd stop. Your Amazon Prime packages came in hot, and wiped out 5 unexpecting people. They probably shopped locally. MDs pushing cigarettes? A look back at TV ads from the 50's and 70's. Amazon Prime may be running a bit behind guaranteed delivery times for Miami: Cargo plane crash kills 5.Breaking NPCs from spells they're programmed to follow is a fool's errand. Some people are READ ONLY Files.RUMBLE Video Link: CLICK THIS AND FOLLOWBMC Link:https://buymeacoffee.com/BaalBustersUpdated GiveSendGo with Links and Details:https://www.givesendgo.com/baalbustersWholistic Wisdom Health and Fitness Coaching with Dan:https://www.patreon.com/c/wisdomfitnessaz/membershipJoin Dr. Glidden's Membership site here:https://leavebigpharmabehind.com/?via=pgndhealthUse Code: fitwit for 25% OFFMake Dr. Glidden Your Doctor. Make Dan Your Coach.The link to get the high quality nutrients you need,Use Code BB5 here for your 90 Essential Nutrients:https://www.azurestandard.com/shop/brand/azurewell/2326The Azure Whole Food Essential Nutrients are 1. Whole Food Multivitamin, 2. Alaskan Cod Liver Oil, 3. Fulvic-Humic Energy Blend, 4. IP6 Supreme. I also recommend adding the Core Copper. Again that code is BB5. Click "Apply Code" in the small blue lettering at checkout, and type, BB5.Go to my site:https://SemperFryLLC.comCode: paratus for 13% OFF Expires Soon!Consider This:https://www.gofundme.com/f/save-our-van-save-our-family-businessFit Wit YouTube channel:https://www.youtube.com/@WisdomFitnessAZExtremely affordable coaching:https://www.patreon.com/c/WisdomFitnessAZWholistic Wisdom Coaching for a Fresh and Natural new life path.Become a supporter of this podcast: https://www.spreaker.com/podcast/ba-al-busters-broadcast--5100262/support.
Cellular Health, Renewed Energy & Longevity:The conversation between Scott and Dr. William Haas focused on health optimization, with a deep dive into cellular health, inflammation, and the role of peptides. Dr. Haas explained his approach, emphasizing the importance of addressing redox balance, detoxification, and repair in a methodical way before considering interventions like peptides. They discussed the limitations of conventional medicine and the value of functional medicine when personalized and data-driven. Scott shared his personal experiences with health optimization, including his use of BPC-157 for a shoulder injury and his journey with advanced blood panels. The discussion highlighted the need for individualized care, the dangers of protocol-driven or "easy button" approaches, and the importance of energy freedom alongside other freedoms. They also touched on the challenges of navigating the health and wellness industry, including concerns about some practices and the role of AI in interpreting health data. Your Co-Host Today:What if you could feel 20 years younger in just 90 days? Today's guest, Dr. Will Haas, is making that possible for high performers nationwide. A board-certified integrative medicine physician and Founder of VYVE Wellness, Dr. Haas specializes in cellular optimization—helping executives, entrepreneurs, and professionals unlock more energy, sharper focus, and renewed vitality. A regular contributor to media outlets, including Men's Journal and Yahoo Life, he's here to reveal how science-backed longevity can elevate both performance and life satisfaction. Today's Top 3 Takeaways:Inflammation and the Role of Redox in HealthPersonal Health Journey's with Blood Panel and Hormonal AnalysisImportance of Energy Freedom and the Role of Peptides Today's Guest Co-Host Links:VYVE Wellness | Transformative Health & Wellness ServicesVYVE Wellness @vyvewellness on InstagramVYVE Wellness on YouTube Mentioned Influencers:https://vinnietortorich.com/- Founder of NSNG, No Sugar No Grains, Vinnie Tortorich Watch us on YouTube:https://youtu.be/OkW9ub53x0E Show Notes:Health Optimization and Functional Medicine: Scott and William discussed health optimization approaches, with William explaining the concept of "redoxing before you repair" - the importance of balancing oxidative stress through antioxidants before addressing inflammation. They explored the value of regular blood panel testing, with William recommending quarterly or six-month monitoring of specific markers, and discussed the challenges of individual variability in health responses. The conversation covered functional medicine approaches versus traditional protocols, with William cautioning that while functional medicine can become too protocolized, the key is finding practitioners with sufficient experience to understand and interpret patient-specific data effectively.Bioregenesis and Root Cause Healing: Scott and William discussed the concept of redox and the bioregenesis methodology, focusing on the importance of addressing underlying issues like detox and inflammation before repairing the body. William emphasized that focusing solely on repair methods like peptides or stem cells is ineffective if the root causes, such as poor diet or toxins, are not addressed first. Scott shared his personal experiences with wildland firefighting and the impact of poor nutrition on health, aligning with William's perspective on the need for upstream interventions to promote healing.Integrative Medicine and Nutrition Discussion: William shared his 15-year journey in integrative medicine, starting from his teens when he was introduced to Andrew Wild's books about clean living and anti-inflammatory diets. He discussed how medical education lacks sufficient focus on nutrition, with Scott agreeing that MDs typically receive only limited nutritional training during their education. William expressed concern about how peptide treatments are sometimes used as a quick fix rather than addressing underlying health issues, emphasizing that peptides should be viewed as tools to support the body's natural healing processes rather than standalone solutions.Initial Testing in Healthcare Practices: William and Scott discussed the importance of comprehensive initial testing before starting treatment, with William explaining that his practice recommends a deep dive cellular diagnostic panel covering seven areas of cellular health and micronutrient assessment as the recommended starting point. Scott expressed frustration that this approach differs from veterinary medicine where thorough testing is standard practice, attributing the difference to insurance company policies. William shared his background as an athlete interested in health optimization, which led him to pursue preventative medicine rather than conventional disease management approaches.Medical Career and Content Creation: William discussed his career journey from athletic development to medicine, including taking time off to get an MBA to better understand the business of medicine outside the insurance system. He shared his experience creating medical content online, noting both the success and challenges of putting himself out there as a physician, including being reported to the state medical board for discussing BPC. Scott acknowledged William's successful content creation and discussed his own experiences with similar therapies, expressing interest in exploring hyperbaric oxygen therapy in the future.Metabolic Syndrome and Healing Processes: Scott and William discussed the importance of addressing metabolic syndrome and inflammation in healing processes, particularly for soft tissue repair. They emphasized the need for early detection of metabolic dysfunction through blood work and the value of working with knowledgeable experts to create personalized healing plans. William highlighted the concept of "energy freedom" as a crucial fourth component alongside time, location, and financial freedom, stressing the importance of proper rest and recovery for overall well-being.YouTube Content vs Medical Treatments: Scott and William discussed the benefits and challenges of creating content on YouTube versus other platforms, with William expressing concerns about the lack of personal connection on YouTube. They also talked about the differences between in-person and remote medical treatments, particularly regarding hormone therapy and peptide treatments. William shared his experience with patients who had received inconsistent advice from other wellness centers, and they discussed the potential for a follow-up episode after September when William's schedule opens up more.01:05:00 – Final Words Our Final Words of the Show:There's a lot of talking about time, location, and money freedom, and I think there's this kind of fourth door that nobody really kind of sells or explores, and it's kind of the Energy Freedom. We tripped all over it with this Redox kind of concept, which is you get plenty of guys who hit all three. We got time well dialed in, and you know we're doing all the right things, and we've kind of built financial freedom, but they can't enjoy any of it because they're just flat exhausted at 6o'clock. That's something I experienced early on in my career as an entrepreneur, and where I was kind of logging in late hours in my 30s and staying up till 11 o'clock, midnight, 1am, and telling myself, "Hey, I'm getting more done. I'm super productive." Yet I walked around kind of foggy and kind of exhausted and kind of burnt out by 3o'clock every day. As I kind of changed that pattern in life to more of a nine to five. I didn't bed at nine and up at five. I'm kind of much sharper, and I'm not a morning person, but kind of much sharper, much more productive. This is kind of really just tying in this concept of Energy and the importance of recharging the body so it has what it needs to do the repair. I just want to kind of close that note out, which is kind of drilling home that the importance of the Energy Freedom to enjoy the other things you've been working so hard on. Positive Action Forward:Submit a 5-Star ReviewGet Scott's Charitable Book! - HotshotBook.comCheck out the Boots Refuel Fund - FuelFoundations.orgNeeds Strategy and Execution - FuelUpMarketing.com
Jay Yang, MD You cannot have progress without research. In our latest episode, Dr. Jay Yang of the Karmanos Cancer Institute in Detroit, MI, breaks down the essentials of MDS care, from risk-based treatment plans to managing fatigue and exploring promising new therapies. Tune in to find out why the future of MDS treatment is brighter than ever. DOWNLOAD TRANSCRIPT CLICK HERE to participate in our episode survey. Mentioned on this episode: Myelodysplastic syndromes (MDS) MDS patient videos Acute myeloid leukemia (AML) Allogeneic stem cell transplant Graft-vs-host disease Clinical Trial Support Center Additional Blood Cancer United Support Resources: Information Specialists Free Nutrition Consultations Free telephone/web patient programs SHARE web series Online videos Free booklets Young Adult Resources Young Adult Online Chat Support groups Patient Community Caregiver support Caregiver Workbook Medical Debt Case Management Program Financial support Survivorship Workbook Advocacy and Public Policy Mental Health Resources Episode supported by Bristol Myers Squibb and Taiho Oncology, Inc. The post Myelodysplastic Syndromes (MDS): Progress, Possibility, and What's Next first appeared on The Bloodline with Blood Cancer United Podcast.
Please visit answersincme.com/ZGK860 to participate, download slides and supporting materials, complete the post test, and get a certificate. Presented by Amer Zeidan, MBBS, MHS. In this activity, an expert in myelodysplastic syndromes (MDS) discusses approaches to optimize management of anemia in lower-risk MDS. Upon completion of this activity, participants should be better able to: Translate the latest clinical trial data to the management of patients with lower-risk MDS; Evaluate evidence-based strategies for optimizing the use of available agents in lower-risk MDS; and Design treatment plans that effectively sequence available therapies in patients with lower-risk MDS.
We have the two Canarian teams in first and second, the first time this has ever happened in the history of Segunda, there was the will they won't they t-shirt saga for Las Palmas in Ceuta, Leganes moved to 4 points with a win over Real Oviedo despite receiving 51 shots across the first two MDs and all 3 of the newly promoted sides that have played so far picked up points. In part 2 we cover the Canarian teams making it 6/6 points to go top and second, Leganes' 4 points and 51 shots received on their own goal across two games, a star of Segunda who is about to leave the division and it is Liam's turn to bring us his 3 things to look out for from this MD. Why wait until Thursday for part 2? Listen early and ad free for as little as 3 Euros a month on Patreon or sign up for our extra content tier to hear the second 45 of the show, FREE TRIAL FOR 7 DAYS and then from as little as 3 Euros per month (billed in your local currency). On the link below; www.patreon.com/spanishsegundashow Have a month free on us, use this link to get your first month free! https://www.patreon.com/SpanishSegundaShow/redeem/17CEC ===== Join our FREE prediction league - Ballkie - click on the link below! Pick the results of all 11 games every week to score points, win prizes and see how you compare to other listeners of the show! https://www.ballkie.com/leagues?join=d3589541d1 === Spanish League, Spanish Football, Soccer podcast, Soccer podcasts, Español football, Spanish Segunda Division, LaLiga, LaLiga Hypermotion, Learn more about your ad choices. Visit podcastchoices.com/adchoices
Nvidia publie un trimestre record. CA à 96,2 Mds, guidance à 108 Mds pour le T3, largement au-dessus du consensus. Et pourtant le titre plonge à l'annonce.Ce soir-là, ce n'est pas la donnée financière qui a sauvé l'action. C'est Jensen Huang, en direct sur le call, qui balaie les doutes sur la demande et sur la stratégie d'investissement de Nvidia chez ses propres clients.Sa CFO, elle, ne nie rien. Elle annonce une nouvelle rallonge de financement pour un labo IA. Et pendant que le narratif rassure, le marché du crédit price déjà un risque différent : les spreads liés à ces montages Nvidia se traitent aujourd'hui comme une signature BBB, pas AA.Dans cet épisode : ce qui s'est vraiment passé sur ce trimestre, pourquoi le titre a fait un aller-retour de plus de 7% en une soirée, et le seul indicateur qui, pour moi, mérite d'être suivi de près dans les mois qui viennent.Force et Honneur
Financial agreements are often viewed as a way for one person to protect their assets from the other. But a prenup, postnup or separation agreement can begin with a more constructive question: What are we trying to accomplish financially? In this episode of the We Chat Divorce Podcast's Divorce Explored series, Karen Chellew and Catherine Shanahan challenge the traditional mindset surrounding financial agreements. Rather than focusing only on what happens if a marriage ends, couples can use these conversations to decide what they want to build together, what should remain separate and how both people will stay financially informed. The conversation is especially important when one spouse leaves the workforce, contributes to the growth of a business, manages the household or depends on the other spouse's income. Catherine expands on insights she recently shared in a USA TODAY article about former stay-at-home wives who became financially vulnerable when their marriages ended. Karen and Catherine discuss: How prenups can support transparency instead of signaling distrust Questions couples should ask before deciding what remains separate or marital The long-term financial impact of leaving the workforce to care for a family When a postnuptial agreement may help an already-married couple create a new financial understanding The difference between managing the family's money and using money as a form of control Why financial disclosure should continue as careers, businesses, assets and family responsibilities change How to begin a difficult financial conversation one manageable question at a time You do not have to know whether your marriage will continue or end before you start understanding your finances. Know what you have. Know what you owe. Understand what you are agreeing to. Financial clarity should not begin when you are getting divorced. It should be part of the financial relationship all along. My Divorce Solution does not draft prenuptial, postnuptial or separation agreements. These are legal documents with requirements that vary by state. MDS helps individuals and couples understand the financial information behind those decisions so they can move forward with greater clarity, confidence and control. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today's episode is focusing on what you need to know regarding myelodysplastic syndrome (MDS). This will include the high yield facts on risk factors, diagnostic work-up, staging and treatment of MDS, we were overdue do this this topic, last done in 2022.
We have the two Canarian teams in first and second, the first time this has ever happened in the history of Segunda, there was the will they won't they t-shirt saga for Las Palmas in Ceuta, Leganes moved to 4 points with a win over Real Oviedo despite receiving 51 shots across the first two MDs and all 3 of the newly promoted sides that have played so far picked up points. In part one of this week's show we are going to take a look at how the four newly promoted teams are getting on in the division and discuss the Las Palmas Ceuta off field controversy. In part 2 we cover the Canarian teams making it 6/6 points to go top and second, Leganes' 4 points and 51 shots received on their own goal across two games, a star of Segunda who is about to leave the division and it is Liam's turn to bring us his 3 things to look out for from this MD. Why wait until Thursday for part 2? Listen early and ad free for as little as 3 Euros a month on Patreon or sign up for our extra content tier to hear the second 45 of the show, FREE TRIAL FOR 7 DAYS and then from as little as 3 Euros per month (billed in your local currency). On the link below; www.patreon.com/spanishsegundashow Have a month free on us, use this link to get your first month free! https://www.patreon.com/SpanishSegundaShow/redeem/17CEC ===== Join our FREE prediction league - Ballkie - click on the link below! Pick the results of all 11 games every week to score points, win prizes and see how you compare to other listeners of the show! https://www.ballkie.com/leagues?join=d3589541d1 === Spanish League, Spanish Football, Soccer podcast, Soccer podcasts, Español football, Spanish Segunda Division, LaLiga, LaLiga Hypermotion, Learn more about your ad choices. Visit podcastchoices.com/adchoices
Join Dr. Glidden's Membership site here:https://leavebigpharmabehind.com/?via=pgndhealthUse Code: fitwit for 25% OFFMake Dr. Glidden Your DoctorVideo Version: https://www.youtube.com/watch?v=SRnF_O89ebQSubscribe to Fit Wit on YouTube: https://www.youtube.com/@WisdomFitnessAZA realization came to me. There's a tier system of society that is selective by intelligence level, and then financial status when we're dealing with medical care. The MDs and their "science" may actually be made intentionally bad and the worst most dangerously inept methods championed so that the vast majority are subjected to its rotten fruits. It's up to you whether you decide to remain with the healthcare intended for hylics, and people who are not smarter than a 5th grader, but share a similar maturity level. MDs were meant to keep their numbers down. It's up to you to wake up, and recognize you don't belong down there with the rest of the mob.You're not the full person you were meant to be. You may even be suffering from mental and emotional upheavals that have less to do with you being broken, and more to do with you being nutrient deprived. So much can change in a person just like you when they get everything they need. This is the solid-reality message, and there's more. Some people's mental, along with their physical health can be compromised by habitual intake of all the wrong foods. If you poison your body and it has to deal with it every day, it can make you fatigue, inflamed, and even irrational, or impulsive.DR G Marathon of the Minds Day 3: Dr. Glidden wants students, not patients. What's that mean? He wants to teach you enough to be independent, and wise enough to spot harmful recommendations when you do face your MD. The inverse of what you need is so often what the MDs pressure you to do. Rather than waste time, energy, and MONEY on prescriptions, insurance, and co-pays only to get sicker, get onboard with us. We all thrive on a Glidden submarine over on his membership site.Hit your health and fitness goals, and outperform your old self.STOP WASTING GYM DAYS. Your time and your effort are priceless, so stop throwing it away simply because an industry posing as an authority on fitness never taught you what your body needs to function at its highest, natural, and powerful level.Contact me through my website contact page to set up a fitness, health and nutrition holistic coaching plan that is like no other. I am a certified personal trainer with 2 of the greatest NDs as resources for the valuable guidance offered. It doesn't matter if you're 18 or 80, I can help you get better results and live a healthier existence.Contact me here:https://www.semperfryllc.com/contact.htmlFull site: https://SemperFryLLC.comCode: paratus for 15% OFF Expires Soon!Become a supporter of this podcast: https://www.spreaker.com/podcast/ba-al-busters-broadcast--5100262/support.
Join Dr. Glidden's Membership site here:https://leavebigpharmabehind.com/?via=pgndhealthUse Code: fitwit for 25% OFFMake Dr. Glidden Your DoctorVideo Version:https://www.youtube.com/watch?v=cPTtQACy0yQDR G Marathon of the Minds Day 2: Dr. Glidden wants students, not patients. What's that mean? He wants to teach you enough to be independent, and wise enough to spot harmful recommendations when you do face your MD. The inverse of what you need is so often what the MDs pressure you to do. Rather than waste time, energy, and MONEY on prescriptions, insurance, and co-pays only to get sicker, get onboard with us. We all thrive on a Glidden submarine over on his membership site.Hit your health and fitness goals, and outperform your old self.STOP WASTING GYM DAYS. Your time and your effort are priceless, so stop throwing it away simply because an industry posing as an authority on fitness never taught you what your body needs to function at its highest, natural, and powerful level.Contact me through my website contact page to set up a fitness, health and nutrition holistic coaching plan that is like no other. I am a certified personal trainer with 2 of the greatest NDs as resources for the valuable guidance offered. It doesn't matter if you're 18 or 80, I can help you get better results and live a healthier existence. Contact me here:https://www.semperfryllc.com/contact.htmlFull site: https://SemperFryLLC.comCode: paratus for 15% OFF Expires Soon!Become a supporter of this podcast: https://www.spreaker.com/podcast/ba-al-busters-broadcast--5100262/support.
In Part 2 of Tara's conversation with Dr. Lindsey Berkson, they continue the discussion by looking at the different forms and delivery methods of HRT, including Bi-Est, estradiol, estriol and progesterone. They discuss why the way a hormone is delivered can matter, why vaginal progesterone may work differently from oral or topical progesterone, and why individual response matters when choosing a delivery method. The conversation then moves into testosterone and breast health, including the role of hormone metabolites and estrogen receptors. Dr. Berkson also shares her thoughts on mammograms and breast cancer screening, including her own experience of finding breast cancer shortly after receiving a negative mammogram. This episode ultimately comes back to one of the biggest themes of the entire conversation: don't blindly follow a protocol simply because it's considered standard. Understand the evidence, understand the limitations, and make informed decisions with appropriate medical support. In Part 2: Why Tara switched to an estradiol patch Dr. Berkson's history developing menopause supplements Progesterone, puberty and menstrual health Why hormone education is missing from conventional medical training Why Bi-Est? Bringing estradiol and estriol back into the conversation Testosterone, muscle, brain health and breast health Why progesterone delivery needs to be individualised Oral vs vaginal vs topical progesterone How Dr. Berkson approaches mammograms, ultrasound and other screening methods The breast cancer Dr. Berkson discovered after a negative mammogram Why Dr. Berkson created Everything Breast Cancer and her personal mission to help women navigate breast cancer Dr. Lindsey Berkson Lindsey Berkson, MA, DC, CNS, DACBN was a Distinguished Hormone Scholar at the Center for Bioenvironmental Research (CBR: Tulane/Xavier Universities). She is a leading figure in integrative medicine, renowned for her expertise in hormones, nutrition, digestion, and environmental science. With a background as a clinician, professor, bestselling author, and radio show host, she brings a wealth of experience to her work. At the CBR, she collaborated with pioneers in estrogen and sex-steroid receptor research. Dr. Berkson is also a respected educator, teaching MDs and pharmacists in advanced certification courses. She has developed innovative nutraceuticals, holds patents in bioidentical hormone therapy, and has contributed to groundbreaking research on dialysis/pharmaceutical medications and nutrition. Dr. Berkson consults internationally, focusing on medical nutrition for breast cancer, inflammatory bowel disease, renal problems, and complex health issues. Dr. B's Links: Email - admin@drlindseyberkson.com Webpage - www.drlindseyberkson.com Memberships - www.drlindseyberkson.com/membership Agile Thinking Substack - https://drlindseyberkson.substack.com/ Biotics Products - https://drlindseyberkson.com/bioticsproducts/ Hormones: Vilified to Vindicated (Course) - https://drlindseyberkson.com/v2v/ Oxytocin Medicine - https://drlindseyberkson.com/oxytocinmedicine/ **Get $100 off Dr. Berkson's Everything Breast Cancer and/or Everything Hormones Courses by using the code: PC100TARA https://drlindseyberkson.com/everythingbreastcancer/ https://drlindseyberkson.com/everything-breast-cancer-nonprofessional/ https://drlindseyberkson.com/everythinghormones/ Estradiol vs. Bi-Est Debate, watch here: https://www.youtube.com/watch?v=u-p82VW1weA&t=2508s Watch Tara's Instagram Live with Dr. Berkson here: https://www.instagram.com/reel/DN6ieQRE0PI/ Fix Your Gut Masterclass Stop Blaming the Food! The Real Reason You've Still Got Bloating and Pooping Problems and How to Fix Your Gut for Good. In this free, live masterclass Tara will walk you through the real reason your gut symptoms keep coming back, no matter what you've tried, and what actually needs to happen to fix them properly, at the root, for good. [Save your spot HERE]
Join us with as we dive into two challenging cases of myelodysplastic syndromes (MDS) in this episode featuring Dr. Amer Zeidan, from the Yale School of Medicine. The discussion focused on real-life scenarios from community settings, exploring treatment decisions in both frontline settings and cases of disease progression. In the first case, we examined a 74-year-old gentleman with persistent anemia and discussed the implications of his diagnosis, treatment options like erythropoiesis-stimulating agents (ESAs) and luspatercept, and the importance of timely intervention. The conversation highlighted the evolving landscape of MDS treatment, including the significance of molecular risk stratification and the potential for improved patient outcomes. The second case featured a 67-year-old woman whose disease has progressed despite initial treatment with luspatercept. Dr. Zeidan shared insights on the next steps, including the use of hypomethylating agents (HMAs) , the role of transplant, and the management of side effects associated with these therapies. Tune in for an informative discussion that not only addressed treatment strategies but also emphasized the importance of patient-centered care and the need for ongoing monitoring and support. Don't forget to like, subscribe, and share your thoughts with us! If there are specific topics or cases you'd like us to cover in future episodes, reach out to us. Episode Highlights: Overview of MDS and its treatment landscape Case discussions on treatment decisions for anemia and disease progression Insights on the use of luspatercept and hypomethylating agents Management of side effects and the importance of patient education Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Apple Podcast: https://podcasts.apple.com/us/podcast/oncology-brothers-practice-changing-cancer-discussions/id1653340966 Follow us on social media: • X/Twitter: https://x.com/oncbrothers • Instagram: https://www.instagram.com/oncbrothers • Website: https://oncbrothers.com/ Thanks for tuning in! We are the Oncology Brothers. #MDS, #MyelodysplasticSyndrome, #HMAs, #HemeMalignancy, #OncologyBrothers
Does estrogen really cause breast cancer? It's one of the biggest fears women have when considering HRT, and in this conversation, Dr. Lindsey Berkson takes Tara back to where much of that fear began. They unpack the history of the Women's Health Initiative, how the original messaging around hormones shaped medical practice, and what later analyses of the research have shown. Dr. Berkson explains why she believes estrogen has been misunderstood, including the difference between estrogen's effects on different receptors and why "estrogen-positive" breast cancer does not necessarily mean estrogen caused the cancer. They also discuss research involving women with ER-positive breast cancer who received estrogen and what those studies reported. Dr. Berkson then shares her own breast cancer story and why it ultimately led her to spend decades researching hormones. This is a fascinating conversation about how medical messaging evolves, why women need to understand the details behind the studies, and why Tara believes these are conversations women deserve to have. In Part 1: The history of the Women's Health Initiative and why it was created What the early research was actually showing about estrogen and breast cancer The controversial press release that changed the conversation around HRT What 20 years of reanalysis of the Women's Health Initiative revealed Oral vs topical vs vaginal estrogen: why delivery method matters Tara's experience with vaginal progesterone and sleep/anxiety The controversy surrounding oral progesterone The debate around estriol What "estrogen-positive" breast cancer actually means The theory behind estrogen and progesterone fueling breast tumors Dr. Lindsey Berkson Lindsey Berkson, MA, DC, CNS, DACBN was a Distinguished Hormone Scholar at the Center for Bioenvironmental Research (CBR: Tulane/Xavier Universities). She is a leading figure in integrative medicine, renowned for her expertise in hormones, nutrition, digestion, and environmental science. With a background as a clinician, professor, bestselling author, and radio show host, she brings a wealth of experience to her work. At the CBR, she collaborated with pioneers in estrogen and sex-steroid receptor research. Dr. Berkson is also a respected educator, teaching MDs and pharmacists in advanced certification courses. She has developed innovative nutraceuticals, holds patents in bioidentical hormone therapy, and has contributed to groundbreaking research on dialysis/pharmaceutical medications and nutrition. Dr. Berkson consults internationally, focusing on medical nutrition for breast cancer, inflammatory bowel disease, renal problems, and complex health issues. Dr. B's Links: Email - admin@drlindseyberkson.com Webpage - www.drlindseyberkson.com Memberships - www.drlindseyberkson.com/membership Agile Thinking Substack - https://drlindseyberkson.substack.com/ Biotics Products - https://drlindseyberkson.com/bioticsproducts/ Hormones: Vilified to Vindicated (Course) - https://drlindseyberkson.com/v2v/ Oxytocin Medicine - https://drlindseyberkson.com/oxytocinmedicine/ **Get $100 off Dr. Berkson's Everything Breast Cancer and/or Everything Hormones Courses by using the code: PC100TARA https://drlindseyberkson.com/everythingbreastcancer/ https://drlindseyberkson.com/everything-breast-cancer-nonprofessional/ https://drlindseyberkson.com/everythinghormones/ Estradiol vs. Bi-Est Debate, watch here: https://www.youtube.com/watch?v=u-p82VW1weA&t=2508s Watch Tara's Instagram Live with Dr. Berkson here: https://www.instagram.com/reel/DN6ieQRE0PI/ Fix Your Gut Masterclass Stop Blaming the Food! The Real Reason You've Still Got Bloating and Pooping Problems and How to Fix Your Gut for Good. In this free, live masterclass Tara will walk you through the real reason your gut symptoms keep coming back, no matter what you've tried, and what actually needs to happen to fix them properly, at the root, for good. [Save your spot HERE]
A rash baffled 25 years of dermatologists. It disappeared in a week once Dr. Steven Zodkoy traced it to a childhood memory. Here's what that case, and the concept of a "biofilm," has to do with your migraines and your bladder. Dr. Chris Motley sits down with Dr. Steven Zodkoy, a chiropractor and applied kinesiologist who became the first in his field to pass the American College of Nutrition exam, a credential previously reserved for MDs and PhDs. Thirty-five years into practice, Dr. Zodkoy specializes in the patient conventional medicine gave up on: the migraine sufferer, the "recurring UTI" patient who never actually had a UTI, the chronic fatigue case with a normal bloodwork panel. His framework rests on one idea most doctors do not test for: the biofilm, a sticky protective layer that bacteria, viruses, mold, and parasites lay down to hide from the immune system and from treatment. Once one pathogen builds a biofilm, Zodkoy argues, it invites others in, which is why a "cured" infection so often resurfaces as something else entirely, chronic sinusitis becoming Lyme-like fatigue, a bladder infection becoming a lifetime of unexplained pelvic tightness, a resistant childhood strain becoming an adult autoimmune diagnosis. Key Takeaways Biofilms are why a "cleared" infection keeps coming back as something else. A biofilm is the mucous-like shield a bacterium, virus, parasite, or mold colony builds to hide from the immune system and from antibiotics. Once it's there, he says, it invites other pathogens to shelter in it too, which can explain why chronic sinusitis, Lyme-linked fatigue, and mold exposure so often show up in the same patient. Interstitial cystitis is frequently a tight-bladder problem being treated as a recurrent UTI. Dr. Zodkoy's read: stress and anxiety tighten the bladder, it never fully empties, and what's left behind gets infected, so the antibiotic treats a symptom while the muscle stays tight and the infections keep returning. His protocol adjusts the pelvic floor and pubic symphysis, then layers in biofilm-breaking supplements and emotional work. A 25-year rash resolved after one round of Neuro-Emotional Technique tied to an age-seven memory. Every physical test on this patient, mold, yeast, parasites, heavy metals, came back clean. Emotional testing didn't. His migraine protocol runs liver support first, nervous system second, emotional work third, in that order, on purpose. Dr. Zodkoy's 1992 theory ties migraines to a slow-functioning liver overloaded by chemical exposure, hormones, or diet. He walks us through his 8-week liver protocol, 16 weeks including autonomic nervous system support, and a 96% success rate once emotional work is added. You cannot do deep detox or trauma work on a nervous system that has nothing left. There's no point moving to detox, biofilm-clearing, or emotional release until a patient's self-rated energy crosses roughly 50 to 60 out of 100. [00:00:00] Cold open: migraines, interstitial cystitis, chronic fatigue, and the biofilm nobody explains [00:02:02] Origin story: "doctor, lawyer, doctor" and practicing three months before 25 [00:04:04] Why he became a nutritionist first: the autonomic nervous system as the missing piece [00:06:08] Finding a hidden emotion: the six-minute visit versus a real history [00:09:37] The HPA axis toolkit: DHEA, GABA, adaptogens, and a gut bacterium built for stress [00:11:27] NET, emotion code, and generational trauma: "it doesn't have to be real, it has to be believed" [00:14:36] The 25-year rash: a muscle test, a forgotten age seven, and a mother's confession [00:19:04] Migraines: the 1992 liver theory, the 80/20 split, and a claimed 96% success rate [00:23:43] Interstitial cystitis is not a UTI: the tight bladder nobody is treating [00:27:06] Killing the biofilm: natokinase, antimicrobials, and cranial electrotherapy stimulation [00:31:29] The sympathetic-parasympathetic seesaw, and why healing collapses without it [00:34:59] The "oomph" scale: testing cortisol at home and in the office [00:36:27] The protocol in order: glandulars, adaptogens, and parasympathetic support, dosed on purpose [00:43:30] Chronic fatigue, sinus biofilms, and the "house party" that becomes Lyme, EBV, and mold [00:47:19] Parasites in America, and the TG/HDL ratio he says predicts heart risk [01:00:02] Closing: where to find Dr. Zodkoy, and a teed-up follow-up on the healthcare system Resources Mentioned Tools & Products Biofilm Clear: Zodkoy's stated favorite combination product for breaking down biofilms, made up of natokinase, serrapeptase, lumbrokinase, and bromelain. He describes dosing at 2000 IU for patients under 50 and up to 4000 IU for patients over 50 with abnormal bloodwork. CP2305 (referenced in audio as "PC2305"): a Lactobacillus gasseri probiotic strain studied for stress and HPA-axis effects. True Laser: a home low-level laser device Zodkoy places over the vagus nerve. Cranial electrotherapy stimulation (CES) units: clip-on-the-ear devices Zodkoy uses for anxiety, sleep, depression, and (with pads placed over the bladder) interstitial cystitis relief. Adrenal glandular products (brand examples given: Adrenal Complex from Designs for Health, Adrenal from Orthomolecular, Cortex from Thorne Research), used at a fraction of label dose, one pill in the morning only, per Zodkoy's protocol. Adaptogens referenced: ashwagandha, holy basil, rhodiola, cordyceps. • Nervous-system support referenced: DHEA, L-theanine, GABA, phosphatidylserine, adrenoglandulars. Antimicrobials referenced for biofilm-associated infections: berberine, olive leaf, oregano. Nutrients referenced for liver-support migraine protocol: B vitamins, glutathione, NAC. Concepts referenced: HPA axis (hypothalamus-pituitary-adrenal): the stress-response pathway Zodkoy targets before any other intervention. Applied kinesiology: manual muscle testing Zodkoy uses to distinguish emotional, physical, biochemical, parasitic, fungal, or toxic causes of a symptom. NET (Neuro-Emotional Technique), Emotion Code, Body Code: hands-on techniques used to locate and release stored emotional triggers. Sympathetic and parasympathetic nervous system balance: the "seesaw" framework underlying his treatment sequencing. • Triglyceride-to-HDL ratio: Zodkoy's preferred cardiovascular risk marker over total cholestero Want more of The Ancient Health Podcast? Subscribe to the YouTube channel. ------ Follow Doctor Motley! Instagram TikTok Facebook Website Follow Dr. Steven Zodkoy https://www.instagram.com/drstevenzodkoy/ ------ *You can get cell support in gummy form: Mitopure now starts at $79, when you go to timeline.com/DRMOTLEY. *Join Doctor Motley's newsletter for TCM insights and regular podcast updates https://www.doctormotley.com/ *Do you have a ton more in-depth questions for Doctor Motley? Check out his course on emotions and the body in his membership. You'll find other courses full of his expertise and clinical wisdom, plus bring all your questions to his weekly lives! To try risk-free for 15 days click here https://www.doctormotley.com/15
Welcome to the Oncology Brothers podcast! In this episode, we were joined by Thomas LeBlanc, MD MA, from the Duke Cancer Institute to discuss the treatment algorithm for myelodysplastic syndrome (MDS). We dived deep into the importance of risk stratification in MDS, exploring lower-risk, intermediate-risk, and higher-risk categories. Dr. LeBlanc shared insights on the role of next-generation sequencing (NGS) and the Revised International Prognostic Scoring System (IPSS-R) in guiding treatment decisions. Key topics included: Treatment options for lower-risk MDS, including the use of erythropoiesis-stimulating agents (ESAs) and luspatercept The significance of ring sideroblasts and del(5q) in treatment selection The management of anemia, thrombocytopenia, and neutropenia in MDS patients The emerging role of imetelstat for heavily transfusion-dependent patients and its unique side effects Join us as we unpacked the complexities of MDS treatment and emphasize the importance of personalized care for patients. Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Follow us on social media: X/Twitter: https://x.com/oncbrothers Instagram: https://www.instagram.com/oncbrothers Website: https://oncbrothers.com/ Don't forget to like, subscribe, and hit the notification bell for more insightful discussions in oncology! #MDS, #MyelodysplasticSyndrome, #RiskStratification, #OncologyBrothers
You have not heard it all, contrary to the American colloquialism "Now...I've heard it all." I've seen many professionals trade in their shingle for the wine trade. Attorneys, eye doctors, MDs, and others. Most of the time they are seeking the lifestyle that is purported to belong to winemaking. For sure, this type of career move will test your resolve; many find out that it wasn't and isn't what they were seeking. Enter Dr. Jan Krupp, a celebrated Internist who got the calling. Can you imagine? Solid career, solid practice, helping others all tossed to the side of the road to enter the wine trade. But when he was told that his most desired property was virtually useless for wine grapes, he jumped at the opportunity- yes, jumped at the opportunity. This adventure would become the famed Stagecoach Vineyards....and turn into a multi-million dollar sale to Gallo. Trading a stethoscope for a shovel is not your everyday midlife crisis, but Dr. Jan Krupp makes it sound as natural as coaxing vines from volcanic rock. In this episode, you're invited into the world of a physician who took the road less traveled—straight up an unplantable Napa hillside—to plant the seeds of what would become the famed Stagecoach Vineyard. You'll discover how Dr. Jan Krupp applied scientific precision and creative drive to transform barren land into one of California's most celebrated grape sources, all while welding together risk, relentless work, and a bit of luck in the kiln of family partnership. Listen as he peels back the layers of his own journey—from home winemaking in a garage to collaborating with legendary consultants and top winemakers, each step a blend of experimentation and vision. You'll gain an inside look at his new book, Forging Eden, an exploration not just of Napa terroir, but of personal transformation and resilience. Along the way, Dr. Jan Krupp and Paul Kalemkiarian reveal the untold challenges that come with creating a world-class vineyard, wrestle with the shifting tides of Napa's hospitality and wine tourism, and debate the future of authentic winemaking in the age of crown caps and experiential brands.
In this episode of the Habit Based Lifestyle Podcast, host Jesse Ewell breaks down why the biggest breakthroughs in business, health, marriage, and leadership don't come from more information – they come from your daily habits. Takeaways: From chiropractor to hormone expert: Dr. Mark went from traditional chiropractic and 6 neuropathy clinics to a cash-based hormone and peptide practice serving thousands. Insurance battle became the turning point: A 10‑year fight and a potential $4M clawback (which he ultimately won) pushed him to leave insurance and go all‑cash. "Normal" labs are not optimal: He focuses on free testosterone, SHBG, estradiol, and hematocrit, not just "normal" total T ranges. Low T shows up before libido issues: Brain fog, stubborn belly fat, poor gym results, and non‑restorative sleep are early warning signs. Men need estrogen too: Zeroing out estrogen wrecks recovery, sleep, mood, and erections; balance—not elimination—is the goal. Sub‑Q TRT works better for many: Easier injections, good absorption, and fewer estrogen/hematocrit issues than old-school IM shots. Hormones can change mental health trajectories: Optimizing testosterone has helped some men avoid or later taper psych meds (with their MDs). Peptides & NAD are the next layer: Tools like BPC‑157 + TB‑500, Glow/Clo, Mot‑C, and NAD are used for repair, fat utilization, energy, and anti-aging. You can't out-inject a bad lifestyle: Without protein, movement, sleep, hydration, and collagen, meds and peptides only "rent" results. Massive opportunity for chiropractors: Peptides are a projected $300B market, and patients will get them somewhere—quality sourcing (503A/503B) and real education matter. Content builds authority: Books, podcasts, and social media turned Dr. Mark into a recognized expert—and he urges practitioners to "embrace the suck" and start creating. Perfect for entrepreneurs, small business owners, and anyone looking to scale their business through social media. Click the link below and learn how Jesse and his team can help you achieve similar transformative results. To find out more about the VIP weight loss system email me directly or reach out on socila media. Learn more about Jesse though the following links: VIP WEIGHT LOSS SYSTEM HBL Lifestyle Secrets Group on Facebook Personal Website HBL Website Instagram Email
Following the FDA approval of allogeneic regulatory T cell–containing immunotherapy with hematopoietic stem and progenitor cell (HSPC) and T cells-vldq (Tregzi; Orca-T), CancerNetwork® spoke with Wendy Stock, MD, about what this decision means for the treatment of patients undergoing hematopoietic stem cell transplantation for different hematologic malignancies. Additionally, she discussed how this option fits into the treatment landscape alongside other options like posttransplant cyclophosphamide (PTCy) and other next steps for improving outcomes associated with matched donor transplants.Stock reviewed findings from the phase 3 Precision-T trial (NCT05316701) that supported the approval of Orca-T, noting that the data appeared to be “effective across all populations” for patients with acute myeloid leukemia, acute lymphoblastic leukemia, high-risk myelodysplastic syndrome (MDS), and mixed-phenotype acute leukemia. Furthermore, she detailed what adoption of Orca-T might look like on an operational level, described the agent's ability to reduce the risk of graft-versus-host disease, and emphasized referring patients early to transplantation.The approval, Stock said, marks the beginning of potentially allowing “higher-risk populations to move forward with the knowledge that it is possible to undergo transplant safely.” She noted that the FDA's decision may inspire the field of transplant graft engineering to look more carefully at other options that might further improve transplantation outcomes.“Over the last 10 years, we have had incredibly exciting, still-to-be-tweaked methods for improving outcomes for patients undergoing transplant, which is such an important procedure for curing or [achieving] long-term survival for patients with acute leukemias and high-risk myelodysplastic syndromes,” Stock said. “This is a big advance, and it needs to be studied further, including comparisons with other major improvements in the world of transplant, such as PTCy.”Stock is the Anjuli Seth Nayak Professor of Medicine, cochair of the Leukemia Committee for the National Cancer Institute–supported Alliance for Clinical Trials in Oncology, and coleader of the Clinical and Experimental Therapeutics Research Program at the University of Chicago Medicine Comprehensive Cancer Center.References FDA approves allogeneic regulatory T cell-based immunotherapy with HSPC and T cells-vldq for use in matched donor hematopoietic stem cell transplantation for adults with hematologic malignancies. News release. FDA. June 30, 2026. Accessed July 15, 2026. https://tinyurl.com/38s3wznr Meyer EH, Salhotra A, Gandhi AP, et al. Orca-T vs allogeneic hematopoietic stem cell transplantation (Precision-T): a multicenter, randomized phase 3 trial. Blood. 2026;147(11):1168-1177. doi:10.1182/blood.2025031313
The average person with NTOS will not get a correct diagnosis for 4-5 years. They will likely see about 6 specialist MDs looking for a solution and some relief. Some will have unnecessary spinal fusion or cardiac procedures or be on pharmaceuticals for years that don't help. Here's what we need to do to help. Online Courses: https://richardhazel.podia.com IG: @richhazel
Isabel Ahmann, Alex Fouts, and Nia Tanui, and Giana Michels just survived their first year of PA school alongside the MDs, and to celebrate they're riding 68 miles across Iowa. This year's Register's Annual Bike Ride Across Iowa features a day focused on Why I Ride--that day, July 22, the route runs from Boone to Marshalltown. These physician associate students are dedicating their day to funding cancer screening and prevention across Iowa, especially in the rural communities where the rates are climbing fastest. They're already over $1,000 in fundraising, with sponsors on the shirts, and every rider is committing a dollar per mile. Join the fundraising efforts! https://goldrush.uiowa.edu/miles-that-matter-cycling-to-combat-cancer-in-iowa
Send us Fan MailInside Dental College: The Truth Every NEET Aspirant Must KnowIs Dentistry really a good career option after NEET?In this insightful episode of The Kapeel Gupta Career PodShow, we sit down with Dr. Aakansha Mishra, a BDS graduate and MDS (Periodontology) scholar, to uncover the real journey of becoming a dentist. From dental college life and clinical training to specialization, career opportunities, challenges, and the future of dentistry, this conversation offers valuable insights for every NEET aspirant, student, and parent. If you are confused between MBBS and BDS, wondering whether dentistry is the right choice, or simply want to understand the realities of the profession, this episode is for you.
Dr. Deb Muth 00:03What if symptoms that have been dismissed for years aren’t all in your head, but signs of an underlying tick-borne illness or complex chronic condition that needs a different kind of care? Today, we’re talking with Ginger Southley DNP, one of the leading voices in Lyme disease, mortgage, and tick-borne illness care. She brings decades of clinical experience and a deeply patient-centered approach to some of the most misunderstood conditions in medicine. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, explore cutting-edge approaches to healing, and empower you with the tools to take charge of your life.I’m Dr. Deb, and today we’re diving into the complex world of Lyme disease, co-infections, more jellins, and the deeper factors that can keep people stuck in chronic illness. If you or someone you love has been struggling with unexplained symptoms, fatigue, brain fog, pain, or a long road to answers, this episode is for you. So, as usual, grab your cup of coffee, tea, or whatever helps you settle in, and let’s get started on today’s journey toward deeper healing.You guys can put one of the ads in here, that’d be great. No. There we go. Because otherwise, yes, we’re going to get chatting, and we’ll forget. I pre-recorded the intro part, so we can just dive in, and I can ask you, like, how you got into this, and then we can start our conversation again. Dr. Ginger Savely 02:01Okay, I can’t remember what I said last time, but that’s alright, I’ll just… Dr. Deb Muth 02:04So, we need to protect them. Well, welcome back to Let’s Talk Wellness now. I have a dear lady, Dr. Ginger. She’s being so gracious because we already goofed up our first recording we did on Riverside a few months ago, and she’s been gracious enough to come back and join us again and do it all over again while we’re actually recording. So, Dr. Savely, welcome to the show. Dr. Ginger Savely 02:26Thank you. Thank you so much for having me. I appreciate it. Dr. Deb Muth 02:30Dr. Ginger, tell us a little bit about how you got involved with tick-borne disease and Morgellons, because you are truly a legend in this world, and I’d love for everybody to hear your story. Dr. Ginger Savely 02:42Well, I just to very briefly go over, I got into the tick-borne diseases because my daughter was so very sick with it, and I started learning everything I could, and the next thing I knew, I was picking it up in my… population, I was doing primary care, family practice, and I was picking it up in that group. And then word got around, and next thing I knew, I’m treating a lot of tick-borne disease, became 50% of my practice, then 70% of my practice. And then, a few years into it, I started having, well, first of all, Dr. Harvey, who was a Lyme doctor in Houston, Texas, he and I were constantly communicating about things and comparing notes, and he emailed me and said, have you seen any patients with you know, blue fibers coming out of them? And I said, I don’t think so, but I’ll start looking for it. So, then I did, and I started asking all my Lyme patients about it, just, have you had any unusual things come out of your skin?And once I asked them, then, lo and behold, a certain subset of them said, well, yes, as a matter of fact, I do have that, but I’ve just learned not to mention it, because people think I’m crazy, so I just never, you know, say a word about it. And so I started picking up a lot of these patients, and you know, of course, since I first came at this by way of tick-borne diseases, Lyme, etc. I figured, okay, these people I know have tick-borne disease, so let’s treat that and see if maybe their immune system recovers to the point where they can handle whatever this is causing the Morgellen’s disease. And so that’s the way I approached it at first, just treating underlying infections, since I had no idea what was causing more dilins. I just noted an association with Lyme disease. And so, I put out a paper about 20 years ago. I published a paper that had to do with Basically, one thing… the main point of the paper was correlatingLyme disease with Morgellins, saying that 97% of my Morgellins patients ended up having Lyme or another tick-borne infection. And, so this is… this is the first publication that basically kind of made that correlation, you know, between the line. And I think it’s been taken out of context a lot, misinterpreted. I never for a minute said that Lyme causes more gelins, not at all, and we… that’s a leap way too far for us at this point. I just noticed an association. So, whatever that may mean, who knows? But, you know, certain illnesses, like, for example, AIDS patients are famous for getting thisCarpacea sarcoma. And it doesn’t mean AIDS causes that sarcoma, because other people get it too. It’s just highly associated with the tooth, so… We might be talking about a disease that’s highly associated with tick-borne infections, or maybe it’s caused by a co-infection that we don’t even know about. Or maybe it’s something entirely different, and the tick-borne diseases were just suppressing the immune system to the point where The person succumbed to whatever this was whenever they got into contact with it.And so, I began, you know, just experimenting and trying different cocktails of things to see what would work. And as I began to treat, I realized that The more jealous patients did notget better with a Lyme protocol. They got better when I used a Bartonella protocol, a specific group of antibiotics that’s used to treat the Bartonella infection. Now, again, I’m not saying for a minute Bartonella causes more gelin, but I’m just saying that when I use the treatment for Bartonella, that’s when I get the best results on my mortgageellin’s patients. And I also have noticed that my Morgellen’s patients tend to have other symptoms that are typical Bartonella symptoms, like a lot of the neuropsychiatric symptoms, neuropsychiatric, sorry, and the, the streaks that they’ll get on them, the red tracks. Spontaneous scratches, all that. So those we do see on our Bartonella patients that don’t have more gelin.So, I started… it was… my early patients were, I would always say, you’re the lab rats, because we’re just experimenting with everything, and they were more than willing. I mean, these people were so desperate, they were so miserable, and so… upset by the way they’ve been treated by the medical establishment, that they were, every one of them, at a point of saying. I don’t care what you give me. it… if it… even if it kills me, I’d rather be dead than have to deal with this, you know? Dr. Deb Muth 08:07Try something, right? Dr. Ginger Savely 08:08That’s pretty drastic, I know, but that’s where they were. They were at a point where, I don’t care, I’ll take any risk just to do this. However, I’ve always been using FDA-approved medications, and, you know, it’s just… naturally, I’m treating, sort of in my own, kind of invented way, because there’s no textbooks you can go to for this, there’s no algorithms, there’s no treatment protocols for this, because more than half of the medical world doesn’t even believe it exists. So, we… you know, I looked very carefully at all these patients in my office with magnified, lighted magnification, and I was seeing amazing things. I mean, I couldn’t believe it. Sometimes the hair on the back of my neck would stand out when I would see these things, because You know, bright blue fibers are not supposed to be coming out of the human body. And I would even pull at them with the tweezers, and, you know, they would not come out, so it wasn’t like a matter of they were just stuck on there, you know, from fabrics or something, as dermatologists often claim is the case. Dr. Deb Muth 09:24I had a patient once with Morgellons, and she got a magnification glass that she could attach to her phone, and she, like, took pictures of what was coming out of her skin and video recorded it and sent it to me, and oh my gosh, it’s crazy. crazy how these things come out. And if you don’t see it under a microscope like that, it’s really hard to understand what’s going on. Dr. Ginger Savely 09:48Exactly. And, you know, what we’ve always said is dermatologists usually carry about a 12X scope in their pocket, but you need really more like 60X to see this stuff, because very rarely can you see it with the naked eye. I mean, sometimes you can, but you do need that lighted magnification in order to see it. I do have some patients come to me, they have all the symptoms more jealous, but they say, I don’t think I have fibers, and I said, well. but you… have you really looked with magnification? They said, well, no, I just thought I’d see them, and I… so then it turns out they actually do have them, but… Yeah. So I… I’ve been fascinated mostly then in treating these patients by how… diverse each patient is, because I can develop a protocol that’s working fantastically on this patient, and try it on the next patient. It doesn’t work at all. Dr. Deb Muth 10:49So… Dr. Ginger Savely 10:50So, it’s just back to the drawing board, every single patient. And of course, there’s a huge variance in degree of severity of this illness. I have everyone… everywhere from people who are totally functional, going to work, and just have this annoying thing going on, all the way to people who are just completely marred and disfigured and can’t even get out of bed. So, you know, of course, there’s quite a difference there, and naturally, it’s a lot more difficult to treat the more severe cases. And often with the more severe cases. Our best hope is reducing symptoms significantly to where they’re tolerable. But in the very severe cases, I don’t think I’ve ever had a person yet get 100% well. But I do have plenty of others that have gotten 100% well, but maybe they wouldn’t fall into the most serious category, you know. So, but I, I’ve, tried everything. I have tried… antifungal protocols, antiviral, anti-helminthic, and, you know, just… I’ve tried it all, I swear, I don’t think there’s anything I haven’t tried. And, you know, sometimes you hit on what works for that patient, and it might not… it might be a surprise.I had one patient, I’d been trying the antibiotics with her, we weren’t getting anywhere, and then I just started treating her with itraconazole, an antifungal, and she just… got so much better. And I think probably because in that case, one of her main immune challenges was some… she was probably exposed to mold, she had probably had colonization in her sinuses or wherever else in her body of the mold. So, that… I think if you can find the main thing that’s… really dragging the immune system down and work on that thing, then hopefully you’ll lighten the load on the immune system to where this Morgelins can take care of itself. Because we do know a lot of people get it and barely get sick at all. A lot of times, people will tell me their spouse, or… their child, or somebody says, oh, they’ve had, like, two tiny lesions, and they’ve had a couple of fibers, and basically, that’s it. So, by that, I’m assuming that You know, this is something that usually only those who are very immune-challenged actually come down with. And that’s what I’ve found through the years, that they are immune-challenged. I’ve had AIDS patients with this. I’ve had people on high-dose corticosteroids because they had an immune… some kind of autoimmune problem.I’ve had several organ transplant patients, because they’re given strong immunosuppressants to… so they won’t reject the organ. So, it’s not 100% Lyme patients, and that’s the thing where I disagree with some of the researchers who are trying to propose the idea that Morgillon’s is a dermatologic manifestation of Lyme. No, I mean, I know how to diagnose Lyme disease. It’s a clinical diagnosis. I have patients that not only are just zero, zero nothing on hygienics.They have not one single symptom of tick-borne disease. When you give them antibiotics, they don’t hurt, because they don’t get better. There is no indication that they have Lyme or co-infection, but they have all the awful skin stuff. And in fact, I have found through the years that those people are kind of my hardest ones to treat, because I don’t know what to work with. You know, I don’t… I don’t want to give them all these antibiotics for tick-borne disease if they don’t really have that. Dr. Deb Muth 14:54Right, hard to find that initial trigger, right? That’s what we’re always looking. Dr. Ginger Savely 14:58Yes, exactly. That industry. Dr. Deb Muth 15:00If we can’t find the initial trigger, how do you know where to start? It’s like a guessing game. Dr. Ginger Savely 15:04I know, so… and of course, the other thing I’ve discovered through the years is that Another immune challenge that is common to all these patients is mold toxicity. So, if I don’t… can’t find any particular infection to treat. Then I… I start thinking about the possibility of… that the patient is mold toxic, that they are… they are living in now, or previously lived in, a moldy home, or maybe they… sometimes they work in a moldy place. Dr. Deb Muth 15:38to him. Dr. Ginger Savely 15:39And for, you know, one quarter of the population, this can be… these mycotoxins are just huge immune suppressants. And so. I used to test that genetic haplotype test that Dr. Shoemaker does. I used to do it on all my more jealous patients. every single one of them came out mold susceptible. So after a while, I just stopped doing it, because I kind of got the point. And also, you know, it’s an expensive test, and insurance often doesn’t cover it. So, But anyway, that… that is… excuse me, I gotta take a drink here, my mouth is dry. Okay, so, alright. Now, of course, I have to figure out where I was. What were you saying? Dr. Deb Muth 16:27We were talking about mold in Schumacher. Dr. Ginger Savely 16:28Oh, yeah. Dr. Deb Muth 16:30for that. Dr. Ginger Savely 16:31Yeah, so you know, mold is the big thing now, right? I mean, I know you’re looking at… we’re all looking at it. I’ve been in the Lyme world long enough to remember back when we didn’t, and we were always so baffled by some of our patients just didn’t get better. Why aren’t they getting better? I’m doing the same thing with them. They’re not getting better. And then come to find out is, you know, they had this, these mycotoxins that they… their body was not able to detox. You know, these people can’t detox the mycotoxins on their own, so… They’re… they’re quite an immune suppressant if you’ve got those going on, so… There’s other things that hold people back from getting well, of course. I find that my PTSD patients can’t get well unless they’re really actively working on the PTSD by going to therapy groups, whatever, you know, it is.I find that people who live in a smoky home where people smoke… well, I don’t even take patients who smoke, because that’s just so counterproductive. to getting well, but sometimes you could look at a home where everybody’s smoking, you know, and that passive smoke, too, is so bad, too. So… and then, of course, I’ve got people, unfortunately, that may be living in abusive situations and can’t get out, and that is also another thing that just halts the treatment.So, you know, everybody… a lot of times people will get online and say, you can never get well from this, don’t even believe anybody that says you can get well. Well, you know, that might be the case in your case, because we don’t know all the various immune challenges you have. But every single patient is different, and that’s why I really can’t publish a protocol or anything like that. Dr. Deb Muth 18:23Yeah, because… Dr. Ginger Savely 18:24it’s kind of more of an art than a science, almost. You know, you just have to feel your way through it, but I… through the years, I have, kind of. start… I found that there’s two antibiotics. If I start with those two, I’m pretty much always going to get some kind of a good response, and that is, a sulfa drug and clarithromycin, the two of them together. Now, that’s not all I do, but that’s a starting point, and I often tell other doctors, look, if you’re going to refer them to me, get them started on those two drugs, you know, just… that’ll already help some. Yeah. And now, of course, a lot of people are allergic to sulfa, so then we have. Dr. Deb Muth 19:10to go. Dr. Ginger Savely 19:11We have to go with something else. But there’s… there’s a lot of different combinations, but basically, I’ve found that, like, if I really go after that Bartonella, and I do a combination, like, the sulfa. doxycycline and, rifabutin, for example. Those… those really get us somewhere. But it’s not… never a quick fix, you know, it’s… it takes a lot of patience, because It’s… it’s slow to get over this. Dr. Deb Muth 19:42Yeah, it seems like, you know, a lot of what we’re talking about in the tick-borne world these days, too, is immune system, right? And there’s so many new things that we’re learning. I was having a conversation with one of the docs from Invita Medical, and they were saying they are seeing a lot of their Bartonella patients are developing cancer. And so all of these things that suppress our immune system, and there’s so many in the world, right? Do you think that’s partially why so many people get overlooked and misdiagnosed when it comes to a tick-borne illness or a mortgage illness? Because they’re… they’re not looking at the root, they’re not looking at the immune system, they’re just kind of looking at symptoms, and of course, everybody thinks these people are crazy, because they have so many bizarre. Dr. Ginger Savely 20:26Symptoms, you know. Well, you know, I always tell my patients, like, if they have to fill out a form or something saying what they have. I always say, say you have Bartonellosis, because Lyme is a trigger word, Magellan’s doesn’t exist. Yes. So, just put you… and you know, when they take that to another doctor. 9 times out of 10, the other doctor doesn’t even know what that is. Dr. Deb Muth 20:52they don’t… Dr. Ginger Savely 20:53They know what cat scratch disease is, they know that name, and that’s an. Dr. Deb Muth 20:58cute. Dr. Ginger Savely 20:58Bartonellosis. But if you say Bartonella to them, they’re kind of confused. And so, in a certain sense, that’s kind of a good thing, because it’s better than it being a knee-jerk reaction, like, get out of here, you’re crazy. Dr. Deb Muth 21:13Time doesn’t exist, what are you talking about? Dr. Ginger Savely 21:15Oh, right. Dr. Deb Muth 21:16Right, it’s… Dr. Ginger Savely 21:17It’s just a… it’s a trigger word, too, but they’re kind of baffled with the Bartonella, like, oh, wait a minute, what is this? Dr. Deb Muth 21:23Yeah. Dr. Ginger Savely 21:24Yeah, that’s always, I think, a good approach to do. But, yeah, I’m always pointing out to my patients that it’s a lot easier to catch Bartonella than Lyme, because there’s so many… there are more different vectors for Bartonella than any other vector-borne infection. So, there’s a number of different bites you can get where you can get Bartonella, and I notice a lot of my patients start having more gellens after a flea infestation, and flea… fleas can give you Bartonella, correct? Dr. Deb Muth 21:58Huh? Dr. Ginger Savely 21:58Cat scratches can, too. A lot of them will bite. Dr. Deb Muth 22:01noceums? Dr. Ginger Savely 22:02It’s like, and in fact, who knows? We don’t even really know all the ones that could possibly give Bartonella, so… Bartonella needs to be really high up on the list of the differential, and it’s not on the list at all with, you know, most. Dr. Deb Muth 22:20Hmm. Dr. Ginger Savely 22:21I don’t even think infectious disease doctors, but certainly not primary care doctors. So, I don’t know what the connection is with Bartonella. It may just simply be, coincidentally, the same things that treat Bartonella, treat this, who knows? The thing is, to say anything like. so-and-so causes more gelands, we’re not even close to being there, you know, in terms of the little research we have. Sure, we have research that shows the presence of certain pathogens in the lesions. But correlation does not equal causation, so we don’t know what that means, that they’re there. But interestingly, they’re about… I think I put this in my book, even, that they’re about, 15 different kinds of skin lesions, where if the patient has Lyme you can biopsy the lesion, and you’ll find Borrelia, the spirochetes, the causative agent of Lyme, in the lesions.So, did the Lyme cause those? nobody knows, because Lyme bacteria loves to go to the weakest part of the body, and so it’s gonna go to any, like, a lesion, it’s gonna go there, because it’s a weak part of the body, so… it may be there just for that reason. It doesn’t necessarily mean it’s causing it. So, lots and lots of work to do in terms of research on this, but it’s very difficult, because, you know, money, we don’t have money for it, and . Dr. Deb Muth 24:07Yeah. Dr. Ginger Savely 24:08There’s no… Dr. Deb Muth 24:08There’s money behind it if we don’t have a drug to fix it. Dr. Ginger Savely 24:10Oh, yeah, that’s true. I mean, you know, we just can’t really get anybody interested in it, like CDC, or… you know, they just are… they did such a… you know, they… they just didn’t really put their heart into doing that one little research study they did. They used all the wrong patients. They didn’t even have an inclusion criteria for the patients, and so they actually… admitted patients to the study that, yeah, they didn’t have more tones. You know, they basically admitted everybody who’d been in with something itchy. You know, of course, a lot of those people didn’t have itchy, so it was… it was so crazy. But, yeah, I feel very… constantly very frustrated that… nobody’s really looking into this, because it is amazing what it can do. I have patients with big holes in their faces, you know. I have a patient who developed, cervical cancer while I was treating her. She had the treatment for it. And it all started out, though, when the doctor saw a huge lesion on her cervix, and when trying to get a little scraping, like to do a biopsy. it just… a hole opened up. Just a hole. Dr. Deb Muth 25:31Gosh. Dr. Ginger Savely 25:32And this is what happens to a lot of my patients, is, like, they develop, kind of, craters in their face. deep holes. Dr. Deb Muth 25:39So… Dr. Ginger Savely 25:40There are so many aspects to this disease. I mean, it’s way more than just the fibers, the filaments. Right, exactly. There’s so many other odd things that’s going on, you know, they all have this sort of a sticky thing all over their skin. Biofilm? I don’t know, but, you know, that’s… they all complain about that like a black tarry stuff coming out of their skin. All the different things that come out, too, you know, they look like, some of them look… do look like little tiny white maggots, and so you can kind of see why people… Do think that they have some kind of an infestation, because an infestation means when you have something along the lines of a, you know, flea, lice, you know, that sort of thing. But many, many patients come to me convinced that that’s what they have. I don’t know, maybe some of my patients do have that as well, but some of the symptoms are very unique to Morgellins, and primarily one. The one symptom that is totally unique to Morgellons is these filaments of different colors that come out. And you can compare Morgillins to, in fact, I did in my book, to any number Of, dermatologic manifestations, and… you can find them that are almost exactly like it, but always the one difference being that Margellis has the fibers, and that other diagnosis does not. So, many of my patients have been misdiagnosed with one of those other things, because the… I think the… the dermatologist or whoever gave the diagnosis wasn’t really looking carefully and didn’t really believe the patient when they said they had filaments. They usually think, oh, they’re just from your clothes, they’re just stuck in you. Dr. Deb Muth 27:32don’t know, they, they don’t. Dr. Ginger Savely 27:34Yeah. Dr. Deb Muth 27:34unfortunately. Dr. Ginger Savely 27:36But they don’t have the curiosity either, which is mind-blowing. Dr. Deb Muth 27:40I know, right? Dr. Ginger Savely 27:41Yeah. If it’s… Dr. Deb Muth 27:42Just kind of straightforward, black and white, that’s all I do. So, Dr. Ginger, how do we help patients feel believed again after being dismissed so long and by so many doctors that. Dr. Ginger Savely 27:55Yeah, huh? Dr. Deb Muth 27:56just don’t know, just don’t know what they don’t know, but they’re trying to be helpful, and unfortunately, sometimes they’re not. They’re hurting the patient by telling them that this is all in their head, or… Dr. Ginger Savely 28:06Yeah. Dr. Deb Muth 28:06It’s just. Dr. Ginger Savely 28:07I mean, of course, we just need some more… much more education of the doctors, right? Dr. Deb Muth 28:13Yeah. Dr. Ginger Savely 28:13They’re the ones that really need… but there are some things that patients do need to be very careful about, and this is just all in the world of learning how to tiptoe around doctors. One thing, never say the M word. If you go in, never say… don’t even suggest it. Just go in there, like, kind of dumb, like, oh, you know, I’ve got this thing going on, what do you think it is? You know, you don’t want to do that. You don’t ever want to suggest a diagnosis either, just act stupid, because that way… They’ll really look into it, you know? Dr. Deb Muth 28:49Yeah. Dr. Ginger Savely 28:50You suggest a diagnosis, then they get irritated, and they just don’t want to even look into it any further. So, you do just sort of have to play dumb a little bit, and just go, gosh, what could this be? I can… you know, and tell the symptoms. Now, even my patients have done that, though. they… a lot of times, they feel, maybe the doctor doesn’t say they’re crazy, but they just feel like they’re kind of brushed aside, like, yeah, well, okay, just put some cortisone cream on it, or, you know, that kind of thing. And I think that just sort of speaks to what’s happened in our medical system lately. I’m very disturbed to hear the stories of people saying they… they… the doctor spent very little time with them. Seemed rushed, didn’t even look at them, didn’t even touch them, certainly didn’t look a magnifier. And it’s… I’m very distressed by the state of healthcare in our country, how this is happening to people. People feel very, very disillusioned with healthcare nowadays. They don’t trust doctors anymore, because, you know, they’ve loved. Dr. Deb Muth 29:58Right. Dr. Ginger Savely 29:58Right. So many times, and so, yeah, I don’t know what we’re gonna do about that predicament. Dr. Deb Muth 30:05I know, my mother-in-law’s 86, and she told me when she went for her physical last year, they… they never took her clothes off, they didn’t even listen to her heart or lungs, or feel her liver, nothing. There was… I said, well, that’s not a physical exam! Dr. Ginger Savely 30:19You know what that is? It’s a Medicare wellness check. Dr. Deb Muth 30:22That’s a… Dr. Ginger Savely 30:22You have to get a Medicare well… but all… this is a Medicare wellness check. They ask you, like, 5 questions. Have you fallen? You know, da-da-da-da. They ask you the questions. I think they weigh you and, you know, review… So, no, it’s not a real physical, it’s just something to make Medicare happy. But, yeah, I know people start being overlooked as they get older. They just kind of, you know, we’re old, whatever, you know, so they don’t… they don’t worry so much. And I’ve had patients as old as… I guess my oldest patient with this was 88. And those… those older people are so miserable, too, when they have this, and they really are just not so much told they’re crazy, but just kind of, whatever. Yeah, their doctors are just not… not particularly interested in what’s going on with them. Dr. Deb Muth 31:17You’re old, what more do you expect? I hear that a lot from my older clients, that that’s. Dr. Ginger Savely 31:21And they’re. Dr. Deb Muth 31:21old. Dr. Ginger Savely 31:22I remember when my father lived to be 94, and the thing that frustrated… and he was a PhD in physiology, so he’d actually worked with MDs a lot, and… Dr. Deb Muth 31:32Yeah. Dr. Ginger Savely 31:32He, he, he used to get so angry, about, about that whole situation, you know? It’s… he, would often say, you know, I go to the doctor, I complain about a pain, and they laugh and say, what do you expect? You’re 90. You know, and my dad was always very active to the end, and he didn’t… it was unusual for him to have the pain, and you know, it should have been looked into rather than just… scoffed at like that. Dr. Deb Muth 32:03missed. Dr. Ginger Savely 32:03It is a problem, you know, in our system, and you don’t find too many specialists in advanced care, in geriatric, whatever you want to call it. I’m… I’m fast approaching that age myself, so I hate to use the word geriatric I think I’m technically geriatric right now, but I can’t… Dr. Deb Muth 32:25We’ll just bypass, that’s just a number. Dr. Ginger Savely 32:27Yeah, yeah. But, yeah, so… Dr. Deb Muth 32:32Andrew, this is a great conversation. I always like to end our show with one last question, and this is always a doozy, so you’ll have to put your thinking cap, or you’ll have to calm yourself when I ask this one. If there was one thing you could change in our medical system today, what would it be? Dr. Ginger Savely 32:52that… Well, it would all have to do with insurance, because insurance is the thing that’s making doctors feel so rushed that they can’t really take time and listen to the patient and properly examine them, because in order to make enough money, with what insurance reimburses them, they just have to, you know, move them in. Dr. Deb Muth 33:12knowing that. Dr. Ginger Savely 33:13And so, you know, if doctors were given… and I bet some of them would really enjoy being able to spend more time with the patient and really listen, but they just can’t because of the way the way it’s all rigged up with health insurance. And so, I want… I want to think that doctors would be happy to do that if they were able to, but, you know, that’s the thing is, I remember writing a paper, even when I was in my undergraduate. about the importance of validation, and this is way before I knew anything about Morgellons, but it was just, like, a big deal to me, like, you know, people need to be listened to and heard, and not brushed off, and validation… You know, when people are validated. they already feel 50% better. It’s just, you know, people will say that after the first visit with me, and I haven’t even done anything yet, that they already feel better, because somebody’s finally taking them seriously, and listening to them, and really… caring, and that’s… I mean, shouldn’t that be basic to all healthcare? I would think it should be, but it’s just not always the case these days, I see. Dr. Deb Muth 34:31Yeah, I agree, I agree. Well, for people who are listening to us, and they’re like, I want to talk with her, I want to meet her, how do they find you? Dr. Ginger Savely 34:41Well, the email address is Lyme DC, Lime, L-Y-M-E-D-C as in District of Columbia, that’s where my office is, limedc at gmail.com. And that is, the address to ask for a new patient packet. I am still accepting new patients. Usually takes a couple months to get in, but I have people fill out paperwork first. sometimes… I mean, I accept most patients, but there’s occasionally, when I look at the history, if they’ve already been to 15 other Lyme doctors, I might not. But, you know, I just like to know in advance as much as I can. Dr. Deb Muth 35:24Yeah. Dr. Ginger Savely 35:24about the patient, because it’s very hard to… you know, I… I can’t really give advice to Mordellin’s people who just talk to me briefly, because, oh my gosh, I need to know so much, I need to know… Dr. Deb Muth 35:34I’m. Dr. Ginger Savely 35:34so much about their history, and their… I mean, it’s just… and I think people get frustrated with me because you know, come on, just give me… give me some tips here real quick, and I was like, it’s so dependent on your story. It’s so individualized that I can’t… I don’t feel even good about trying to give advice to somebody just randomly out of the blue like that. And it… I guess maybe it makes people frustrated and makes them think, oh, you just want the money or something. No, I mean, it’s a lot of responsibility for me, what I do. I’ve been doing… I’ve been taking care of more jealous patients for 25 years. It’s put me at very high risk. I’ve been investigated before by my board, and I’ll tell you, it was not… not a very pleasant thing to go through. And so I said, yeah, I have to keep a little bit of a low profile, and, you know…Yep. And so, people just need to understand that if somebody is taking care of their mortgage, that the healthcare provider who’s taking care of them, they’re taking a personal risk, because they’re doing something that’s not accepted. By the general medical population and by their regulatory board, and so they could very well be called out and even lose their license for doing it. Dr. Deb Muth 36:58Yeah, very much so. It’s good to… to point that out, because these doctors, we’re all putting our neck on the line to help these patients, and sometimes the patients don’t appreciate that or don’t understand that, and they can put us in arm’s way without… sometimes without realizing it, sometimes on purpose. Dr. Ginger Savely 37:16You know, most of my patients, though, are just… they’re so protective of me. You know, they go to the ER for something, and then they’ll say, well, who’s treating your… Dr. Deb Muth 37:27anonymous. Dr. Ginger Savely 37:27so-called Mordellins. well, don’t worry about it, I have a good provider. You know, they just won’t even give my name. But like you say, sometimes accidentally it has happened, and then I get a call from some ER doctor, and it’s usually ER. Dr. Deb Muth 37:44remote. Dr. Ginger Savely 37:44room doctor yelling and screaming at me, and, you know. Dr. Deb Muth 37:48Yeah. Dr. Ginger Savely 37:48Like, oh… Dr. Deb Muth 37:50Yeah. Dr. Ginger Savely 37:50So… Dr. Deb Muth 37:51It’s unfortunate, isn’t it? I had a patient recently see another GI doctor who said, if I prescribed 3 different antibiotics at one time, I’d lose my license. And I’m like, oh, well, not really, but… and, you know, and it upset the patient quite a bit, because now they look at me and they think I’m doing something wrong, because the conventional person told them that it was a problem, and it’s really sad how those things happen. Dr. Ginger Savely 38:16Well, this is something that’s really gotten me very annoyed lately, is when pharmacists see things prescribed that they’re worried about, their job is to contact the doctor and say. Dr. Deb Muth 38:28Yeah. Dr. Ginger Savely 38:29Are you really sure about this? You know, no, what they’re doing is scaring the patients to death. Dr. Deb Muth 38:35Right. Dr. Ginger Savely 38:35They’re saying, okay, here’s what your doctor gave you, but I’m just going to warn you, I mean, geez, taking all those at once, gee, I wouldn’t, you know, and that’s the way they’re talking. So then they lose faith in me, and they don’t realize I’ve been doing this so long, and I’ve had so many thousands of people take this. I know from experience not going to hurt them. But, you know, the pharmacist just read it in a book somewhere, so they assume that it’s going to be awful for. Dr. Deb Muth 39:02Yeah. Dr. Ginger Savely 39:02But that’s… that’s very unprofessional of them to do that. That’s not really their job to do that, but I… it’s happening a lot, I see that. Dr. Deb Muth 39:11happening a lot. Instead of just picking up the phone and calling the doctor. They’re, like you said, upsetting the patient, or calling the board, or those kinds of things. And what happened to that professional courtesy and that exchange of our knowledge bases? You know, I’ve gone to the pharmacy and picked something up, and the pharmacist looks at me, he says, I don’t know what this drug is. And it happened during the pandemic, when I was prescribed hydroxychloroquine, and I’m like, you don’t know what hydroxychloroquine is? Dr. Ginger Savely 39:41Pharmacist? I was like… Dr. Deb Muth 39:43Really? And it was an older pharmacist, and I was like, really? And I… I was like, at first I thought, are you just saying that because you don’t understand why you’re giving it to somebody, or are you saying that to hope that I say something different? Dr. Ginger Savely 39:57Yes. Dr. Deb Muth 39:57Really surprising to me how many medications… Dr. Ginger Savely 40:00Question? Dr. Deb Muth 40:01Yeah, yeah. How many medications the pharmacist really claim they don’t know anything about, or they don’t know how to use it? That’s their job, to know about. Dr. Ginger Savely 40:10Sorry, it’s. Dr. Deb Muth 40:11It’s very scary these days. Dr. Ginger Savely 40:12I’m seeing a lot more incompetence in pharmacists, so many scary mistakes being made all the time now. All started with the pandemic. Yep. Ever since the pandemic, pharmacies are making tons of mistakes. Dr. Deb Muth 40:25Yeah. Dr. Ginger Savely 40:25I remember getting so mad at one one time. I said, look, you have one of the two careers where you’re never, ever allowed to make a mistake. Air traffic controllers and you. Dr. Deb Muth 40:35That’s right. Dr. Ginger Savely 40:36Unfortunately, I’m sorry for you, but you cannot make mistakes. Dr. Deb Muth 40:40Yeah, they can’t. I mean, it can be deadly for them, and they do. Dr. Ginger Savely 40:44Yeah. Dr. Deb Muth 40:45Unfortunately, I think, you know, it’s who they’re hiring, it’s the corporate aspect of the pharmacy these days. Dr. Ginger Savely 40:52Probably so. Dr. Deb Muth 40:53Yeah, it’s a… it’s a big mess. Dr. Ginger Savely 40:55Well, I don’t… I didn’t mean this little part here to scare people. I’m sorry about that, I didn’t… didn’t intend to do that, but I just feel like one thing I would do… I do, is if I… if you go pick up a prescription, don’t walk away from the counter yet. Look at it. Look at the bottle, make sure… Dr. Deb Muth 41:17Hmm? Dr. Ginger Savely 41:18That’s what you’re supposed to get, that the quantity’s right, that everything’s good. Dr. Deb Muth 41:23Because once… Dr. Ginger Savely 41:23you walk away from the… you don’t have any recourse. Right. So before you even leave, you know, just… just check it out and make sure. That’s right. And a lot of times, people are given the wrong quantity, or any number So, they. Dr. Deb Muth 41:36They don’t tell you that your insurance won’t dispense the full amount. Dr. Ginger Savely 41:40Right, they just, they just… Dr. Deb Muth 41:41They don’t have it all on stock, so they’re only giving you a partial fill. They won’t tell you any of those things, and then you. Dr. Ginger Savely 41:47Right. Dr. Deb Muth 41:48Call and get that information from them after the fact, and it’s not fun to try to do that, for sure. Dr. Ginger Savely 41:53Oh my gosh, no. I hate calling pharmacies. Dr. Deb Muth 41:56I know, me too. Well, Dr. Ginger, this was such a great conversation. Is there anything else you want to leave our listeners with before you and I sign off? Dr. Ginger Savely 42:04I just want them to have hope. That’s the most important thing. Because many patients with Morgellons do give up hope, and there’s a high suicide rate in this group. And, you know, don’t… don’t give up hope. Don’t give up. There’s… there are people out there who can help you. I’m not the only one. There aren’t many of us, but there are some other I would be able to refer you to if I can’t take you on. And, you know, just… Just know that there are those of us out there who believe in this, we know it’s real, and we’re just desperately trying to see what we can do to help. Dr. Deb Muth 42:46Well, thank you for all your years of support and patient-centered approach. It’s definitely a blessing to have you. Thank you. Dr. Ginger Savely 42:54Alright, thank you so much for having me. Dr. Deb Muth 43:01Where am I? Thank you so much for joining me today on Let’s Talk Wellness Now. Dr. Savely’s decades of experience working with Lyme disease, co-infection, and Morgellins, and your compassionate, patient-centered approach. are such an important reminder that healing starts with being heard, believed, and truly understood. If this conversation resonates with you, I encourage you to share it with someone who may be searching for answers and hope on their healing journey. Remember, complex chronic illness is not something you have to navigate alone. For more information about Dr. Savely’s work, visit her on her website, and we’ll put those links below. And until next time, I’m Dr. Deb, reminding you to take care of your body, mind, and spirit. Be well, and we’ll see you on the next episode. The post Episode 273 – The Hidden Truth About Morgellons, Lyme Disease & Bartonella | Dr. Ginger Savely first appeared on Let's Talk Wellness Now.
Are you tired of being told “your labs are normal” when you know something is wrong? In this episode, we dive deep into the real root causes behind mystery illness, chronic pain, fatigue, migraines, gut issues, and more.We cover:
Le sujet :Les ETF, option de la facilité, sont devenus l'approche la plus plébiscitée sur les marchés boursiers. Et si c'était finalement une terrible idée ? Une alternative existe : le stock picking.Marie de Raismes revient pour faire le point sur le marché et surtout nous apprendre comment bien choisir ses valeurs et surtout à quel moment les acheter. Et ses arguments sont de poids : lors de son dernier passage sur La Martingale, elle avait proposé un portefeuille de valeurs bancaires qui avait surperformé les ETF les plus populaires sur cette période.L'invité du jour :Marie de Raismes est experte en investissement et cofondatrice de la plateforme hiboo.expert. Au micro de Matthieu Stefani, elle détaille la méthode statistique et fondamentale qu'elle utilise pour identifier les valeurs qui ont le plus de potentiel.Découvrez :La droite de régression : l'outil statistique pour savoir si c'est le moment d'acheterSEB SA : pourquoi sa valorisation à 2,5 Mds€ est une aberration quand sa filiale chinoise est à 4 Mds€Pourquoi acheter un ETF S&P 500 aujourd'hui est un très mauvais calculQuelles sont les valeurs qui ont du potentiel aujourd'huiChapitrage : 00:00:00 : Pourquoi les gérants sous-performent les ETF (les pressions qui ruinent la performance)00:11:06 : Ce qui compte vraiment quand on se positionne sur une action00:15:37 : Qu'est-ce qu'une bonne action00:20:03 : La meilleure métrique pour évaluer le prix d'une action00:25:05 : Le stock picking : le meilleur ratio temps/rendement au monde00:28:47 : L'opportunité en or du moment (cas d'étude en live)00:34:33 : Les big tech : analyse de l'historique et prévisionnelle00:40:11 : Comprendre les valeurs cycliques00:46:31 : Les secteurs sous-cotés00:50:53 : La fiscalité : tout ce qu'il faut savoir00:52:10 : Le portefeuille de Warren Buffett en 202600:55:37 : Le pire conseil qu'on entend sur les réseaux sociauxOn vous a négocié un avantage exclusif chez hiboo.expert. Avec le code MARTINGALE40, les 20 premiers bénéficient de -40% sur les abonnements annuels DATA et Expertise. Passé ces 20 places, le code MARTINGALE reste actif sans limite : -30% sur tous les abonnements, mensuels, annuels ou 3 ans.Merci à notre partenaire Fundora de soutenir la Martingale.Allez sur fundora.fr et prenez le contrôle de vos investissements.Fundora est une plateforme d'investissement. La valeur de vos placements peut augmenter ou diminuer. Votre capital est assujetti à un risque.La libre antenne de votre podcast préféré, Allo La Martingale, a désormais son propre flux ! Abonnez-vous sur Spotify, Apple Podcasts ou votre plafeforme audio favorite pour ne manquer aucun nouvel épisode. Pour s'abonner à la newsletter, c'est ici : https://lamartingale.io/ La Martingale, c'est aussi un assistant IA qui vous apporte des réponses éclairées issues des interventions des experts passés au micro du podcast. Pour tester, direction https://beta.lamartingale.ioLa Martingale est un média d'Orso Media. Vous souhaitez entrer en contact avec a rédaction ? Ou nous soumettre une collaboration ? Ecrivez-nous ici : https://orsomedia.io/contactHébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
Myelodysplastic syndromes (MDS), a rare category of bone marrow disorders that may develop into acute myeloid leukemia, are categorized into risk groups ranging from very low to very high risk. However, this language can be misleading to patients. Low risk (LR) does not equate to low impact or lack of urgency. In this episode, CANCER BUZZ speaks with Amy DeZern, MD, MHS, from Sidney Kimmel Comprehensive Cancer Center, and Christin Blair DeStefano, MD, FACP, from Walter Reed National Military Medical Center, about the importance of aligning language and terminology regarding LR-MDS across academic and community settings. These experts candidly discuss their own collaboration and the importance of early conversations with patients to align expectations on goals, disease trajectory, and treatment sequencing. Guests: Amy DeZern, MD, MHS Hematologist/Oncologist Director, Bone Marrow Failure and MDS Program Sidney Kimmel Comprehensive Cancer Center Baltimore, MD Christin Blair DeStefano, MD, FACP Hematologist/Oncologist Walter Reed National Military Medical Center Bethesda, MD "I really try and individualize [language] to a patient and their family, because I worry that sometimes the terminology 'lower risk' may not correctly convey the impact the disease is going to have on an individual human's life." — Amy DeZern, MD, MHS "Frequent reassessment—questioning our patients about quality of life and if we're meeting the goals they have—should be something that's readily reassessed, especially in the lower risk space, every 2 to 3 months, just to make sure we don't put anybody on autopilot." — Amy De Zern, MD, MHS "There's been such an explosion in understanding the molecular landscape of MDS and slicing and dicing it into different diseases that fall under the MDS umbrella. It has sometimes created a little bit of confusion." — Christin Blair DeStefano, MD, FACP Resources: ACCC Hematologic Malignancies Resources Blood Cancer Awareness Month: Tackling Communication Challenges Addressing Frequency of Care to Improve Quality of Life in Patients with Low-Risk MDS Defining and Managing Erythropoietin Stimulating Agents (ESAs) Failure in Patients with Low-Risk MDS
This month our guests are Rob and Lori Byron, two MDs devoted to health as its affected by changes in our climate and air quality. Lori is a career Pediatrician and Rob, An Internist. Through much of their work life they've worked to draw the attention of healthcare professionals to the immediate implications of climate change and air polution. Together they launched a nonprofit, Montana Health Professionals for a Healthy Climate - now going by the name, Montana Health and Climate.Over the past 7 years their reach has rapidly expanded to serve Montanans across the state who are healthcare professionals with programming extending into schools, communities, neighborhoods and families. Their goal is to raise awareness and enter full collaboration on solutions. Most visionary of their collaborators have been the Native American Tribes. Lori and Rob describe these communities as well ahead in articulating and actualizing priorities for climate health. For Tribes, the health of the land is the health of the people.Enjoy listening in on this conversation. You're sure to leave with new ideas and perspectives.You can learn more about Lori & Rob by spending time on their website: Montana Health and Climate. Find stories of programs that are building enthusiasm for climate repair in schools, neighborhoods, and health care centers. Like the Byron's say, "This is the world's greatest group participation project." We can do this!!!!MUSICAmericana Instrumental 07. Music by Alana Jordan from PixabayAmericana Instrumental 01. Music by Alana Jordan from PixabayAcoustic Ballad, Optimistic Scape. Music by Dvir Silverstone from PixabayOriginal theme music composed and performed by Gary Ferguson.----HILFH is an educational project of Full Ecology. Check us out and let us hear from you.
Tyler Hoffman returns to the show to discuss diagnostics and observability data in embedded systems. We catch up on his life after startup acquisition, explore the hows and whys of keeping product data separate from operational data, and consider the realities of fleet management at scale. Tyler is the co-founder of Memfault. Memfault was acquired by Nordic Semiconductor about a year ago. While Nordic has nRF Cloud as a smaller scale solution for Nordic devices (~100 devices), Memfault will continue to maintain support for non-Nordic platforms as well. During the discussion, Tyler advocates for a "device-in-control" philosophy, emphasizing that edge devices should retain the intelligence to manage their own firmware updates and telemetry. We also discuss the practical constraints of remote fleet debugging, outlining why tools built for high-bandwidth web infrastructure will quickly bankrupt an IoT company, and identifying exactly when a project is too low-bandwidth, or too small, to justify an external observability platform. Christopher shares his recent experiences with Memfault which leads to a discussion of chunks, flash memory buffers and MDS. The Memfault Diagnostic Service (MDS) is a standardized way for BLE devices to send the chunk payloads to a gateway device (mobile phone) which can then forward the data to the Memfault cloud. If you want a deep dive into the reasoning around starting Memfault, Tyler was on Embedded.fm episodes 390: Irresponsible At the Time and 395: I Can No Longer Play Ping Pong. Reaching back into the archives, Elecia, Tyler, and Phillip Johnston were on the Memfault Coredump Sessions podcast, a special crosspost with Embedded.fm, episode 451: From Concept to Launch You can also find technical deep dives on Memfault's Interrupt blog. "What we do makes a difference and you have to decide what kind of difference you want to make." – Dr. Jane Goodall, Reason for Hope: A Spiritual Journey. Transcript
Rob and Paul's final run together before their Coast-to-Coast adventure - about 36 hours before - is a gentle double loop of Finsbury Park. Featuring how the boys are feeling, being a bit too busy, a gig-based wardrobe malfunction, how the C2C compares with the MDS, adventures anticipated, running without a Why, and your brilliant PBs. SUBSCRIBE at https://runcompod.supercast.com/ for early access, bonus episodes, ad-free listening and more...BUY OUR BOOKS; you can get Paul's NEW BOOK Running Through Sand here: https://www.waterstones.com/book/running-through-sand/paul-tonkinson/9781399404013, you can get Rob's book Running Tracks here - https://www.waterstones.com/book/running-tracks/rob-deering/9781800180444 Thanks for listening, supporting, and sharing your adventures with us. Happy running. Learn more about your ad choices. Visit podcastchoices.com/adchoices
"We typically think of the disease progressing for our higher-risk patients because many of them already start with increased blasts or a lot of dysplasia. And they have these chromosomal variants that make them prone to evolving into acute myeloid leukemia (AML). With them, we can anticipate that they are going to progress to AML. And that's what we're trying to prevent. It's kind of like a biologic evolution and not a switch," ONS member Sara Tinsley-Vance, PhD, APRN, AOCN®, nurse practitioner and quality-of-life researcher at Moffitt Cancer Center in Tampa, FL, told Lenise Taylor, MN, RN, AOCNS®, TCTCN™, oncology clinical specialist at ONS, during a conversation about long-term myelodysplastic syndrome (MDS) considerations for oncology nurses. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Earn 0.75 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by June 19, 2027. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge related to management of long-term side effects related to myelodysplastic syndrome and its treatment. Episode Notes Complete this evaluation for free NCPD. ONS Podcast™ episodes: Episode 415: Myelodysplastic Syndrome Treatment Considerations for Oncology Nurses Episode 411: An Overview of Myelodysplastic Syndrome for Oncology Nurses Episode 256: Cancer Symptom Management Basics: Hematologic Complications Episode 220: Oncologic Emergencies 101: Febrile Neutropenia and Sepsis Clinical Journal of Oncology Nursing articles: Exploring Experiences of Bereaved Caregivers of Older Adult Patients With Acute Myeloid Leukemia Family Caregiver Preparedness: Developing an Educational Intervention for Symptom Management Incorporating Nurse Navigation to Improve Cancer Survivorship Care Plan Delivery Oncology Nursing Forum article: An Integrative Review of Sex Differences in Quality of Life and Symptoms Among Survivors of Hematologic Malignancies ONS book: BMTCN® Certification Review Manual (second edition) ONS course: Psychosocial Dimensions of Cancer Care™ ONS Learning Libraries: Survivorship Learning Library Hematology, Cellular Therapy, and Stem Cell Transplantation Survivorship Care Plan Huddle Card American Association of Colleges of Nursing End-of-Life Nursing Education Consortium (ELNEC) American Cancer Society: Living As a Myelodysplastic Syndrome Survivor American Society of Hematology Aplastic Anemia and MDS International Foundation: MDS Toolkit Blood Cancer United: Myelodysplastic Syndromes Family Caregiver Alliance HealthTree Foundation Inspire: MDS Support and Discussion Community Myelodysplastic Syndromes Foundation To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "When our higher-risk patients have disease-related progression, their [malignancy] can transform to AML. And we know this occurs in about one-third of our patients and is one of the most serious late effects. Even in lower-risk disease, we have this worsening marrow failure with or without increasing blast, where [patients] may have just started out with anemia, then they also develop neutropenia and thrombocytopenia. And as those counts worsen, we usually know that their disease is progressing." TS 2:47 "The golden rule is looking at the blood count but also looking at the patient and how they're doing over time. The backbone of MDS monitoring is the complete blood cell count with the differential. What you're looking for is trends over time. How many units of blood are they receiving, what threshold are you going to transfuse them at, and how many units of blood are they getting at a time? ... And then paying attention to the absolute neutrophil count for infection risk. [Another] really important piece of when you look at the differential with patients is seeing if they have any abnormal cell counts. Do they have circulating blasts? Are those monocytes going up? If you start to see blasts circulating or increasing monocytes, then their disease could be changing, even if they have low-risk disease." TS 15:58 "For lower-risk disease, we're paying more attention to their quality of life, how the patient's tolerating therapy, trying to help them stay safe over the long haul, and starting them on iron chelation if it matches that patient and they can have access to those drugs. ... For higher-risk disease, if the patient's goal is to be cured and not to progress to AML, you want to get them to transplant if that's [also] one of their goals. If they do evolve into AML, try and see what treatment matches best for them." TS 22:28 "You want to start early for patients who have febrile neutropenia—that's really important when a patient is an hour or two away from a center where they can get started on antibiotics. So, you have to think outside the box. What can we do to keep them safe? ... I know this group in Alaska that's in our advisory meetings and they try to facilitate transportation to Seattle. That's the closest academic center to them. Collaborating with telemedicine appointments, starting earlier, developing that strong relationship with patients, and contacting them between visits [can help patients living in rural areas]." TS 25:22 "I think the biggest [psychosocial challenge] I see is a lot of unmet anxiety and depression counseling. A lot of times, [patients are] losing their place in their family because they're the ones that need all the help now. Also, the uncertainty that goes along with the diagnosis. There is communication skills counseling, and End-of-Life Nursing Education Consortium (ELNEC) has a lot of training for communication skills and how to really talk to patients. Not that we take the place of a psychologist, but just being able to talk to somebody can go a long way. And if we can get training for that, we can help more patients." TS 31:15
Your Impostor Syndrome Isn't Going Away. Here's Why That's Actually Good News.Imposter syndrome gets talked about like it's a beginner's problem, something you grow out of as your career matures. Katy's here to tell you that's not how it works.After 20 years in leadership, scaling businesses, sitting in boardrooms and speaking to thousands of people on stage, she still has weeks where she questions everything. And she's not alone. 78% of UK business leaders and 80% of MDs admit to feeling out of their depth, they're just not saying it out loud.This episode isn't for people just starting out. It's for experienced leaders who've already proved themselves and are still quietly wondering if today's the day someone finds them out.Katy shares how being made MD of Social Chain at 32 (six months into the role) brought her impostor syndrome crashing to the surface, what working with a therapist taught her about the stereotype she was unconsciously leading from, and why the impostor never fully disappears, no matter how much you achieve.But here's the reframe: what if it's not supposed to? What if your impostor syndrome isn't a flaw to fix, but a signal to follow?In this episode: The three ways impostor syndrome shows up in experienced leaders (and why we dress it up as high standards) Why your impostor is actually a growth indicator in disguise The "boost folder" technique that takes five minutes and changes everything How to close the gap between the leader you think you should be and the leader you actually are You're not on your own. And you never were.
Ric Sinclair is the CEO of Cotiviti, an enterprise healthcare software and data company that serves hundreds of health plans — including the top 25 in the country — across payment integrity, interoperability, risk adjustment, value-based care, and member engagement, touching coverage for over 300 million patients and members. Cotiviti pairs algorithms and AI with thousands of clinical nurses, MDs, and content experts in a human-in-the-loop model, working across the full administrative ecosystem that moves between payers, providers, patients, and pharma. Ric's core conviction is that healthcare's central problem isn't a data problem or a technology problem — it's a coordination problem, and what the system has never had is a true infrastructure layer to tie it together. Cotiviti isn't trying to pick a side between payers and providers; the bet is that a neutral party sitting in the middle can drive fair, transparent outcomes and pull down the trillion-plus dollars of administrative waste in U.S. healthcare.We discuss:Why healthcare's core problem isn't a data problem or a technology problem — it's a coordination problem, and what it actually takes to build the first infrastructure layer the system has ever hadThe real difference between owning a decade of data assets (and the Edifecs integration) and becoming the infrastructure the industry runs on — and where Cotiviti is in that build todayHow "human in the loop" works at scale — pairing AI with thousands of nurses, MDs, and content experts so every claim is reviewed fairly and problems get predicted before they happenWhy Ric's answer to AI isn't "cut the 10-person team to 2" — it's "take all 10 and do what 50 could," and what that augment-don't-replace math means for client ROIHow you build trust and accountability into an AI workflow rather than bolting it on — and who's accountable when models start shaping decisions about claims and careHow to sit in the neutral middle between payers and providers who don't trust each other — and what it takes to build something both sides actually believe is fairWhat Ric learned as a working drummer in Nashville before healthcare found him — leading without the spotlight, making others better, and why simplicity is a discipline that transfers straight into businessWhat a truly differentiated healthcare platform looks like five years out — and the test Ric uses for what "winning" means: a family of five at the dinner table who never have to think about the administrative machinery behind their care—Brought to you by: Sage Growth Partners — Value-focused strategy and marketing for growth-driven healthcare organizations. — Where to find Jared: • X: https://x.com/jaredstaylor • LinkedIn: https://www.linkedin.com/in/jaredstaylor/
I'm here to help. I want you and your families to have your best life, happy and healthy. Just because we're trained to trust institutions blindly and not speak out, or even question, doesn't mean that's a safe philosophy to follow. I have been conveying the same message, the same warnings on video and podcasts for over 7 years. We need to free ourselves fro this cultish ritual of poisoning by shots and pharmaceuticals. Please make the change. Give the 90 Essential Nutrients a test drive for at least 3 months and see what it improves for you. In addition, become a member of Dr. Glidden's membership site so when you need him, he can communicate to you what homeopathic remedies to add to help right your ship when it goes off course. I have had life changing, life improving results since I began taking the AzureWell nutrients, and listening to Dr. Glidden's advice. He's helped me through kidney stones pain-free and told me what to take to dissolve the stones so it didn't cause excruciating pain. He's where I go when I want a problem solved. I haven't been to an MD in years. I like solutions, not poisons and suppressive measures that never address the root of the problem. Typically that root is related to a mineral deficiency. I can lead you to the water. It's on you to drink. Join Dr. Glidden's Membership site here:https://leavebigpharmabehind.com/?via=pgndhealthCode: baalbusters for 25% OFFMake Dr. Glidden Your DoctorUse Code BB5 here for your 90 Essential Nutrients:https://www.azurestandard.com/shop/brand/azurewell/2326The Azure Whole Food Essential Nutrients are 1. Whole Food Multivitamin, 2. Alaskan Cod Liver Oil, 3. Fulvic-Humic Energy Blend, 4. IP6 Supreme. I also recommend adding the Core Copper.Use code BB5 for your discount.Become a supporter of this podcast: https://www.spreaker.com/podcast/ba-al-busters-broadcast--5100262/support.
Along life's winding roads we've each worked tirelessly to hone our skills and ultimately become the excellent clinicians we are today. But what happens when being great in the OR isn't enough? Each week on About the Rest, Joe Rodriguez, DNAP, CRNA, gets into the weeds on the definitive podcast for fellow CRNAs and MDs who want to understand how our profession actually works behind the scenes… warts and all. The spiritual sibling of the award-winning podcast Anesthesia Deconstructed, About the Rest takes a commentary-driven approach to facing the infrastructural obstacles that keep holding us back. Because the hard truth is… although our clinical skills are essential, the business of healthcare far too often treats them as commodities. Unapologetically inside baseball, join the podcast where together we become leaders, gain influence, and hone the skills nobody taught in our programs to take control of our careers. To Learn More Visit: ww.abouttherest.com Got a Question? hello@abouttherest.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Tomorrow's podcast is a little different. We're doing a two-part episode. First, we're diving into some of the biggest health and peptide mistakes I'm seeing right now...mistakes that can waste money, delay healing, and in some cases actually make health challenges worse. Then we're going to celebrate one of our amazing CHI members, Susan, who chose a very different path. Instead of guessing. Instead of chasing symptoms. Instead of jumping from supplement to supplement, practitioner to practitioner, or peptide to peptide. She decided to understand what was actually standing in the way of her health. Susan completed advanced testing that revealed she was carrying and actively releasing pesticides, plastics, mold toxins, and other environmental toxicants. She learned where to focus. She followed a roadmap. And she took action. Before I tell you more about Susan's story, here's what we'll cover in today's episode:
High‑risk MDS and AML continue to challenge clinicians, with limited durable responses and few options for older or treatment‑refractory patients. In this sponsored episode of The Top Line, host Stephanie Butler is joined by Dr. Amer Zeidan, Professor of Internal Medicine at Yale School of Medicine, to unpack new ASCO 2026 data that are drawing attention across the myeloid malignancies field.The discussion focuses on mesutoclax, a novel oral BCL‑2 inhibitor evaluated in combination with azacitidine. Dr. Zeidan breaks down early findings showing a 100% objective response rate with CR rate of 40% per IWG 2006 criteria and 90% composite complete response with CR in 60% in treatment‑naïve high‑risk MDS, along with strong efficacy and encouraging safety signals in AML, with over 80% composite CR, and with potent activity in TP53 mutant, as well as zero death within 30 or 60 days and rapid cytopenia recovery.Listeners will hear how mesutoclax’s potency, selectivity, and pharmacokinetic profile may overcome key limitations of existing BCL‑2 inhibitors, and what these results could mean for future frontline treatment strategies.See omnystudio.com/listener for privacy information.
Jay Dhaliwal, founder of Super Patch, joins Mind Pump to break down one of the most unconventional technologies in health and wellness — haptic patches that alleviate pain, improve sleep, boost athletic performance, and more with zero compounds or drugs. Sal opens up about being deeply skeptical until reviewing the peer-reviewed studies, and the guys walk Jay through the entire origin story — from a passion project to help his mother with MS, to 17 years of research, $40 million of his own money, and 16 published peer-reviewed studies. They cover the neuroscience of how skin receptors communicate with the brain, what the studies actually show (50% pain reduction, 85% sleep improvement, 5–8% athletic performance gains in D1 athletes), and why half the teams in the NFL are already using the product. Super Patch — https://mindpump.superpatch.com $30 off — no code needed, discount automatically applied at checkout (price drops from $99 to $69) SPONSORS Seed Daily Synbiotic — https://seed.com/mindpump Code: 25MINDPUMP — 25% off first month MAPS 15 BOGO — https://maps15bogo.com Buy 1 get 1 FREE — limited time (all 7 MAPS 15 programs same price) LINKS Mind Pump Store: https://mindpumpstore.com Maps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia 0:00 - Intro 1:48 - What is Super Patch? Sal's skepticism and what changed his mind 5:13 - How this compares to when red light therapy first came on the scene 8:02 - Jay's origin story — his mother's MS and 17 years of research 13:16 - The Loretta Z database — quarter million EEGs and the search for normative neural networks 20:10 - The first breakthrough — identifying the vestibular response network in 2014 24:47 - First proof: comparing his mother's EEG against the normative database 27:43 - From brainwaves to skin receptors — how Braille unlocked the next phase 30:08 - The 2010 discovery of piezo two ion channels and skin sensation science 34:07 - The first product — socks that improved balance and gait by 31% 36:59 - Brain mapping 35 people with the world's leading EEG expert — the impossible result 39:07 - How the pattern in the patch is designed — 1200 iterations of micro tooling 43:52 - 2017 Japan study — skin sensation is permanently imprinted on the sensory cortex 45:46 - From socks to patches — how pain and sleep networks were identified 49:01 - The first clinical study — 50% reduction in perceived pain, 70% reduction in interference scores 53:02 - Sleep study results — 85% of subjects went from bad sleep to good or great sleep 56:51 - Pain relief comparable to 400mg Advil — without the drug 58:38 - Stress patch — 33% reduction in perceived stress, 24% improvement in mental health factors 1:01:35 - D1 athlete study — 5–8% improvement in lower extremity power at University of Arizona 1:03:55 - Half the NFL is already using Super Patch 1:04:17 - Stacking patches — which combinations work best for athletes 1:05:30 - Neuroplasticity — why your baseline gets higher over time with consistent use 1:07:52 - Full product lineup — pain, sleep, stress, focus, libido, immune, Zen flow state & more 1:11:28 - Appetite suppression pilot — 20% improvement in resting metabolic rate 1:13:32 - 5000 MDs in America now recommending Super Patch
"We want to make sure that we discuss the details of the treatment and what treatments there are, whether it's an oral drug, whether it's a subcutaneous injection or an IV injection, [the patient's] potential for responding, whether this treatment is curative or supportive, and what the number of visits are. All of those different pieces of information that go into the decision-making process are really important," ONS member Sara Tinsley-Vance, PhD, APRN, AOCN®, nurse practitioner and quality-of-life researcher at Moffitt Cancer Center in Tampa, FL, told Lenise Taylor, MN, RN, AOCNS®, TCTCN™, oncology clinical specialist at ONS, during a conversation about myelodysplastic syndrome (MDS) treatment considerations. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by May 15, 2027. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge about the treatment considerations for MDS. Episode Notes Complete this evaluation for free NCPD. ONS Podcast™ episodes: Episode 411: An Overview of Myelodysplastic Syndrome for Oncology Nurses Episode 256: Cancer Symptom Management Basics: Hematologic Complications ONS Voice articles: FDA Approves Luspatercept-Aamt for Anemia in Adults With MDS Infection Prevention for Oncology Nurses Manage Cancer-Associated Anemia With Erythropoietin-Stimulating Agents Whole-Genome Sequencing May Guide Treatment Choices for AML and MDS Clinical Journal of Oncology Nursing articles: Reducing Effects of Hospital-Associated Deconditioning in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation Resilience in Older Adults Diagnosed With Cancer and Receiving Chemotherapy Targeted Drug Therapies: Beyond Blood Counts and Chemistries Oncology Nursing Forum article: Frailty in Patients With Hematologic Malignancies and Those Undergoing Transplantation: A Scoping Review ONS books: BMTCN™ Certification Review Manual (second edition) Hematopoietic Stem Cell Transplantation: A Manual for Nursing Practice (third edition) ONS course: Hematopoietic Stem Cell Transplantation™ ONS Learning Library: Hematology, Cellular Therapy, and Stem Cell Transplantation ONS Symptom Intervention resources: Prevention of Infection: General Prevention of Infection: Transplant Aplastic Anemia and MDS International Foundation: MDS Drugs and Treatments Blood Cancer United: MDS Treatment HealthTree Foundation Myelodysplastic Syndromes Foundation To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "The goals that I try to consolidate to make sure they're consistent with the patient's goals are to improve their counts, especially the anemia or cytopenias. If they're getting blood transfusions, we want to reduce the number of transfusions that they receive because we know that's linked to reduced overall survival, and it really impacts quality of life. ... And then for high-risk patients, it's a more serious discussion because we know that they are the ones who can progress to acute myeloid leukemia (AML). And we're trying to delay progression to AML. That means we're trying to improve their survival and we're also trying to manage their cytopenias and decrease their infection risk." TS 2:28 "If we look at approvals for low-risk disease and high-risk disease, those were really made based on the Revised International Prognostic Scoring System (IPSS-R) and sometimes the International Prognostic Scoring System (IPSS). Under those classification systems, when we think of lower-risk MDS, we think of patients who are primarily anemic but don't have increased blasts in their bone marrow. ... For higher-risk MDS, we want to have that discussion with those patients because their life expectancy is much shorter than patients with lower-risk MDS. We want to see if hematopoietic stem cell transplant would be something that they would be interested in if they don't have a lot of comorbidities and are relatively healthy." TS 11:41 "There are a lot of things to consider—[patients'] blood counts, comorbidities, whether they're frail, and what their goals are. There are some patients where there's no way they would want to go through transplant. And some patients want to be cured, so it just depends on your patient." TS 14:22 "I think of hematopoietic allogeneic transplants as a treatment for more of the patients with higher-risk MDS. ... With the Molecular International Prognostic Scoring System (IPSS-M), a patient can have pretty good blood counts and not have increased blasts in the bone marrow. You could send them for a transplant referral upfront without having to give them additional treatment. ... There is a recent publication that said if a patient doesn't have more than 10% blast, you could refer to transplant as a first option. ... Also, if you had a lower-risk patient who is relatively young and doesn't have any other treatment options, this would also be a patient that you could refer to transplant to see if we could care for them, and then they wouldn't have to be getting transfused all the time." TS 21:12 "I think that we often think low-risk, no treatment needed, but it depends on the person. They often need ongoing supportive care to manage their symptoms even if they're not getting treatment. And just because we're not treating them, active observation, bringing them in to see how they're doing, if they've had infections, if their blood counts are changing, that is paying attention to them and doing something. Just because they're low-risk doesn't mean they don't need anything and we can just schedule for a one-year follow-up." TS 26:30
Rick writes "I was on your show about two years ago regarding my investigations into the potential paranormal aspects of the Bigfoot phenomenon. I would like to update you on my efforts (Quantum Bridge Project) and the progress we've made to date. As you know, I used to be the State Director for the Virginia Chapter of the Mutual UFO Network and investigated numerous UFO sighting reports to include purported "abduction" cases. I transitioned to the paranormal realm because of the apparent similarities in certain cases. I've been with the Center for Paranormal Research and Investigations (CPRI) for the past twenty-four years and, within the past eight years, started conducting "cryptid" research for the same aforementioned reasons. I chose CPRI because of their philosophy and the way they approached the paranormal using the scientific method. The organization has MDs, PhDs in sociology, educators, nurses, chemists, current and former law enforcement officers, etc. CPRI is a Virginia 501(c) nonprofit, educational organization with a Board of Directors. I approached their Board with a written research proposal requesting that we investigate the "cryptid" phenomena in the same fashion they approach the paranormal; using certain specialized instrumentation and equipment like thermal imaging/ recording devises, remote data loggers designed to measure various EM/ radiological fields, and certain environmental conditions. My proposal involved locating a potentially credible cryptid investigator and working with them in their respected field research areas in order to capture supporting data during a sighting. This would not only validate that something is actually occurring, but to potentially explain certain aspects of the phenomenon. I've attached this particular proposal for your reference. One of my investigators located Harley Owens; a fairly new cryptid investigator in the East Tennessee area. Some of his sightings have been validated by other independent investigators, so I decided to work with him. His research area is near Cosby, TN, which is one of the areas the late Scott Carpenter used to investigate. Over the past two years, Ive independently investigated this area with Harley to further gauge his credibility before devoting CPRI resources to this geographical area. During that time, I've seen strange tree structures, heard screams, roars, and strange "barn owl" sounds, I have also seen those infamous" lights" that are seemingly associated with the Bigfoot phenomenon. On one occasion, I saw one of these "lights" at night on my thermal imager. It was moving intelligently through the forest. Interestingly enough, when I tried to see the light without the thermal, it wasn't visible. When I looked through the thermal, it would reappear, indicating it had some type of invisible heat source. Harley was next to me and wanted to see the light through the thermal. When he looked through it, he saw the light and, as it approached a dirt road, he said the light "transformed" into an upright being exhibiting a heat signature. It walked across the road and up an incline towards an adjacent knoll. I didn't see this; however, about one minute later, I heard a loud scream and an "owl' like vocal come from this same knoll. This scream was extremely loud and lasted about two to three seconds. It also sounded like some type of primate. It was immediately followed by an "owl" vocal, which didn't seem right. On another investigation in July of 2024, Harley and I were in his research area one night when we heard a loud, very intimidating roar (not scream) coming from another Ridgeline adjacent to a cemetery, which is the apparent focal point of the activity. This roar was so intimidating and loud, we were concerned for our safety. You could actually feel "rage" coming from whatever made it. I've never heard anything quite like it before, so we decided to pack everything up in order to make a quick exit if the situation called for it. We didn't stay too much longer before we left the area. As you probably know, these so called "orb" sightings are very common in both Bigfoot and paranormal cases, which leads me to some information you and your listeners may find very interesting. Back in 2003, CPRI investigated a case near Bedford, VA. This case involved a lady who lived on a farm in a double wide home. The lady reported seeing shadows, hearing voices and reported poltergeist type activity throughout the house. During the course of our investigation, she related an incident that occurred in the early 80s. She was getting ready for bed, had just turned off the bedroom lights when she saw three "orbs" hovering in a level, straight line at the foot of her bed. They appeared to be the size of a softball and each exhibited a different color; one was orange, one was light blue and the last was reddish They emitted light and then moved in unison (line formation) down her hallway and made a 90 degree left turn into her dinning room. She immediately went to the dinning room to see where they went and couldn't locate them. It was as if they just disappeared. The following morning, she went back into the dinning room and noticed three circular discolored/ burnt marks on her window screen. She believed these orbs went through the screen because they weren't there before, the window was left open and each mark was about the same size of these orbs. We asked her about the screen and, fortunately, she had rolled it up and kept it in her barn and forgot about it. We went to the barn and she pulled it out. The screen still had these three strange marks on it, so we asked if we could have it analyzed. She agreed, so we gave it to one of our members who happened to be a Radiochemist and worked for a federal lab in eastern Virginia. He's no longer with CPRI, so I'm not at liberty to divulge his name or where he worked without permission. He took the screen to his lab for analysis. A few weeks later, he sent us a report with his findings, which were intriguing. I've attached a document containing excerpts of his report to keep him and his employer's information confidential. According to the report, the discolored sections of the screen were highly irradiated. The areas were so irradiated we decided to ask the lady some health questions. Around the same time as the orb incident, she did experience bad flu symptoms, nausea, fever and general weakness, which lasted about a week or two. She thought it was just the flu, but did reveal additional information that brings doubt to that conclusion. A few years later, the had to have hip replacement surgery. After the surgery, the doctor asked if she had ever had radiation therapy. When she said no, the doctor said the bone structure of her hip was porous. It appeared to have been subjected to a type of radiation. Apparently she may have been exposed to a great deal of radiation that night. This is not to say that all orb phenomena contains radioactive properties, but it appears these lights did. In March of 2025, I assembled a team from CPRI and we (along with Harley) conducted a preliminary investigation of the Cosby site. The team consisted of Harley, myself, an archeologist, University Professor and another retired law enforcement officer. We did take some instrumentation with us. During the course of three days, we found several unusual tree structures, interviewed a resident in the area and conducted night surveillance. The primary location was the site of an old cemetery, which seems to be the focal point of the activity. We were able to witness unusual light activity in the cemetery. This took the form of small red points of moving light. Another larger red light was also seen depending in a straight line towards the same Ridgeline that the "roar" was heard a year earlier. Our archeologist witnessed a large, indistinct dark mass cross in front of him through the cemetery. He was wearing an Apple Smart Watch with embedded bio sensor at the time. He was able to pull the heart rate data from the watch and, at the exact time he witnessed this event. His heart rate jumped from 66 BPM to 124 BPM. On one occasion, our professor also witnessed a small green light hovering about thirty feet above the cemetery. These lights couldn't readily be explained. They didn't match the will-o-the-wisp (swamp methane gas ignition) phenomena because the weather was cool, it hadn't rained, low humidity and most of the colors seen were red instead of the signature faint blue-violet glow."
Hot off the presses... it's another freshy fresh from Des and Kara. This was recorded just a few hours after Des ran 2:35 from the main field, and Kara finished commentating the world feed. So... the takes and reactions are as freshy fresh as they can be! You get their thoughts on the races of the day with Korir and Lokedi both defending their titles, and Americans setting all sorts of records on this course. Plus, Des shares the details of her race pacing Ryan after bouncing back from MDS. She was the fastest woman in the main field and second masters on chip time, all with a beer cracked in Newton. Unbelievable running from her and what a day in Boston! Listen in and bask in the after glow with us!
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