Podcasts about tishkoff

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Tishkoff, who is a professor in the genetics and biology departments at Penn, discusses her research into variations in the genetics, as well as the physical characteristics, of ethnically diverse Africans. Her research combines fieldwork, laboratory research and computational methods to examine African population history. She examines how genetic variation can affect a wide range of practical issues – for example, why humans have different susceptibility to disease, how they metabolize drugs and how they adapt through evolution.

In most individuals, the ability to digest lactose, the sugar present in milk, declines rapidly after weaning because of decreasing levels of the enzyme lactase in the small intestine. However, there are individuals who maintain the ability to digest milk into adulthood due to a genetic adaptation in populations that have a history of pastoralism. Sarah Tishkoff, University of Pennsylvania, presents her latest studies of the genetic basis of lactose tolerance in African pastoralist populations. Her team has identified several mutations that arose independently in East African pastoralist populations. This demonstrates a striking footprint of natural selection in the genomes of individuals with these mutations. It shows that the age of the mutations associated with lactose tolerance in Europeans and Africans is correlated with the archeological evidence for origins of cattle domestication. Thus, the genetic adaption for lactose tolerance is an excellent example of gene-culture co-evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 24111]

In most individuals, the ability to digest lactose, the sugar present in milk, declines rapidly after weaning because of decreasing levels of the enzyme lactase in the small intestine. However, there are individuals who maintain the ability to digest milk into adulthood due to a genetic adaptation in populations that have a history of pastoralism. Sarah Tishkoff, University of Pennsylvania, presents her latest studies of the genetic basis of lactose tolerance in African pastoralist populations. Her team has identified several mutations that arose independently in East African pastoralist populations. This demonstrates a striking footprint of natural selection in the genomes of individuals with these mutations. It shows that the age of the mutations associated with lactose tolerance in Europeans and Africans is correlated with the archeological evidence for origins of cattle domestication. Thus, the genetic adaption for lactose tolerance is an excellent example of gene-culture co-evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 24111]

Professors at University of Pennsylvania (Drs. Junhyong Kim, Sarah Tishkoff, Frederic Bushman, Susan Ross, Theodore Schurr) address audience questions on human and microbial diversity and how variation in genetic material reflects our history and shapes our health. This is the second part of an evening that began with talks given by Dr. Kim, Tishkoff and Bushman (see Part 1). The panel discussion is moderated by Dr. Ivan Oransky, Executive Editor at Reuters Health.