The Inner Workings of Cells, Winter 2008

Review for Final Exam: This class covers all topics discussed in the course, with an emphasis on cell signaling.

Lecture 28: The instructor reviews some major pathways dealing with signal transduction and an application of principles learned to cancerous cells.

Lecture 27: Kaplan continues his discussion of signal transduction, the role of signals in cell migration, and the ability of cells to see which direction to move.

Lecture 26: Kaplan talks about properties of signaling modules and different kinds of membrane receptors that interpret signals from outside the cell.

Lecture 25: This class is a wrap-up of cell division and checkpoints in the regulatory cycle, and introduction to how cells interpret various biochemical signals.

Lecture 24: Students learn more about cell division, and introduction to cell checkpoints along the regulatory cycle.

Review for Midterm 2: This covers protein trafficking, the cytoskeleton and cell division.

Lecture 22: This is a continued discussion of the regulation of cell division -- how mitosis is coordinated within the cell.

Lecture 21: The stages of the cell cycle, the regulatory cycle, and biochemical switches involved in these two cycles are covered.

Lecture 20: Kaplan wraps up of the cytoskeleton, relation of microtubles to cell motility, introduction to cell division.

Lecture 19: In this class, microtubule dynamics and stability and how these aspects of microtubules are controlled to produce energy and force for processes such as mitosis.

Lecture 18: In a continued discussion of intermediate filaments, Kaplan talks about their relation to other cytoskeletal filaments and microtubule dynamics.

Lecture 17: This class covers actin polymerization, and an introduction to other parts of the cytoskeleton, such as the intermediate filaments.

Lecture 16: Kaplan continues talking about actin, how it can lead to cell motility, as well as how it and other filament dynamics are regulated within the cell.

Lecture 15: Kaplan discusses how cytoskeletal elements of a cell are involved in cell movement, such as actin.

Review for Midterm 1: This class covers cell biology techniques, cell compartmentalization, cell membranes, the secretory pathway and protein trafficking.

Lecture 14: The professor wraps up protein trafficking and non-secretory transport.

Lecture 12: Kaplan gives an in-depth discussion of in-vitro coupled translation and translocation.

Lecture 11: Kaplan reviews glycosylation and gives an in-depth look at the work done to understand protein translocation and examples of protein trafficking.

Lecture 10: In this continued discussion on protein translocation, Kaplan gives emphasis to glycosylation and the Scavenger pathway.

Lecture 09: Kaplan discusses the secretory pathway, with emphasis on protein targeting and translocation.

Lecture 08: Kaplan talks about how various proteins are directed to certain areas within the cell and to the plasma membrane.

Lecture 07: Kaplan discusses the various classes of membrane proteins and movement of molecules across the membrane.

Lecture 06: This is a continued discussion of cellular membranes and their various functions in biochemical reactions.

Lecture 05: This class wraps up of tools to study complex cellular behavior (including microscopy), and introduces membrane proteins.

Lecture 04: How to use subcellular fractionation and other techniques to study complex cellular processes and molecules.

Lecture 03: This class reviews what characteristics a gene needs to be "necessary and sufficient." A discussion of antibodies and their application to various techniques of cell biologists.

Lecture 02: Goals of cell biologists and the overall course plan are discussed and students introduced to the question of how to study cells.

Lecture 01: Kaplan discusses class mechanics, student questions and the central questions of cell biology.