Podcasts about Translocation

In this JCO Article Insights episode, Michael Hughes summarizes “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma" by Avet-Loiseau et al. published on June 09, 2025 along with an interview with author Dr Nikhil C. Munshi, MD. TRANSCRIPT Michael Hughes: Welcome to this episode of JCO Article Insights. This is Michael Hughes, JCO's editorial fellow. Today I am interviewing Dr. Nikhil Munshi on the “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma” by Avet-Loiseau et al. At the time of this recording, our guest has disclosures that will be linked in the transcript. While some patients with multiple myeloma live for decades after treatment, others exhibit refractory or rapidly relapsing disease irrespective of treatment administered. We term this “high-risk myeloma.” Multiple risk stratification systems have been created, starting with the Durie-Salmon system in 1975 and evolving with the advent of novel therapeutics and novel treatment approaches. In 2015, the Revised International Staging System (R-ISS) was introduced, which incorporated novel clinical and cytogenetic markers and remained, until recently, a mainstay of risk stratification in newly diagnosed disease. Myeloma as a field has, just in the past few years, though, undergone explosive changes. In particular, we have seen groundbreaking advances not only in treatments - the introduction of anti-CD38 agents and the advent of cellular and bispecific therapies - but also in diagnostic technology and our understanding of the genetic lesions in myeloma. This has led to the proliferation of numerous trials employing different definitions of high-risk myeloma, a burgeoning problem for patients and providers alike, and has prompted attempts to consolidate definitions and terminology. Regarding cytogenetic lesions, at least, Kaiser et al's federated meta-analysis of 24 therapeutic trials, published here in the JCO in February of 2025 and recently podcasted in an interview with associate editor Dr. Suzanne Lentzsch, posited a new cytogenetic classification system to realize a shared platform upon which we might contextualize those trial results. This article we have here by Dr. Avet-Loiseau, Dr. Munshi, and colleagues, published online in early June of this year and hot off the presses, is the definitive joint statement from the International Myeloma Society (IMS) and the International Myeloma Working Group (IMWG). What is high-risk multiple myeloma for the modern era? The IMS and IMWG Genomics Workshop was held in July 2023 and was attended by international myeloma experts, collaborating to reach consensus based on large volumes of data presented and shared. The datasets included cohorts from the Intergroupe Francophone du Myélome (IFM); the HARMONY project, comprised of multiple European academic trials; the FORTE study, findings from which solidified KRd as a viable induction regimen; the Grupo Español de Mieloma Múltiple (GEM) and the PETHEMA Foundation; the German-Speaking Myeloma Multicenter Group (GMMG); the UK-based Myeloma XI, findings from which confirmed the concept of lenalidomide maintenance; Emory 1000, a large, real-world dataset from Emory University in Atlanta; the Multiple Myeloma Research Foundation Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile (CoMMpass) dataset; and some newly diagnosed myeloma cohorts from the Mayo Clinic. Data were not pooled for analyses and were assessed individually - that is to say, with clear a priori understanding of whence the data had been gathered and for what original purposes. Consensus on topics was developed based on the preponderance of data across studies and cohorts. In terms of results, substantial revisions were made to the genomic staging of high-risk multiple myeloma, and these can be sorted into three major categories: A) alterations to the tumor suppressor gene TP53; B) translocations involving chromosome 14: t(14;16) (c-MAF overexpression), t(14;20) (MAFB overexpression), and t(4;14) (NSD2 overexpression); and C) chromosome 1 abnormalities: deletions of 1p or additional copies of 1q. In terms of category A, TP53 alterations: Deletion of 17p is present in up to 10% of patients at diagnosis and is enriched in relapsed or refractory disease. This is well-documented as a high-risk feature, but the proportion of the myeloma cells with deletion 17p actually impacts prognosis. GEM and HARMONY data analyses confirmed the use of 20% clonal cell fraction as the optimal threshold value for high-risk disease. That is to say, there must be the deletion of 17p in at least 20% of the myeloma cells on a FISH-analysis of a CD138-enriched bone marrow sample to qualify as high-risk disease. TP53 mutations can also occur. Inactivating mutations appear to have deleterious effects similar to chromosomal losses, and the biallelic loss of TP53, however it occurs, portends particularly poor prognosis. This effect is seen across Myeloma XI, CoMMpass, and IFM cohorts. Biallelic loss is rare, it appears to occur in only about 5% of patients, but next-generation sequencing is nevertheless recommended in all myeloma patients. Category B, chromosome 14 translocations: Translocation t(14;16) occurs in about 2% to 3% of patients with newly diagnosed disease. In the available data, primarily real-world IFM data, t(14;16) almost always occurs with chromosome 1 abnormalities. Translocation t(4;14) occurs in about 10% to 12% of newly diagnosed disease, but only patients with specific NSD2 alterations are, in fact, at risk of worse prognosis, which clinically appears to be about one in every three of those patients. And so together, the CoMMpass and Myeloma XI data suggest that translocation t(4;14) only in combination with deletion 1p or gain or amplification of 1q correlates with worse prognosis. Translocation t(14;20) occurs in only 2% of newly diagnosed disease. Similar to translocation t(4;14), it doesn't appear to have an effect on prognosis, except if the translocation co-occurs with chromosome 1 lesions, in which case patients do fare worse. Overall, these three translocations - t(14;16), t(4;14), and t(14;20) - should be considered high-risk only if chromosome 1 aberrations are also present. In terms of those chromosome 1 aberrations, category C, first deletions of 1p: Occurring in about 13% to 15% of newly diagnosed disease, deletion 1p eliminates critical cell checkpoints and normal apoptotic signaling. In the IFM and CoMMpass dataset analyses, biallelic deletion of 1p and monoallelic deletion of 1p co-occurring with additional copies of 1q denote high-risk. In terms of the other aberration in chromosome 1 possible in myeloma, gain or amplification of 1q: This occurs in up to 35% to 37% of newly diagnosed disease. It upregulates CKS1B, which is a cyclin-dependent kinase, and ANP32E, a histone acetyltransferase inhibitor. GEM and IFM data suggest that gain or amplification of 1q - there was no clear survival detriment to amplification - is best considered as a high-risk feature only in combination with the other risk factors as above. Now, in terms of any other criteria for high-risk disease, there remains one other item, and that has to do with tumor burden. There has been a consensus shift, really, in both the IMS and IMWG to attempt to develop a definition of high-risk disease which is based on biologic features rather than empirically observed and potentially temporally dynamic features, such as lactate dehydrogenase. Beta-2 microglobulin remains an independent high-risk indicator, but care must be taken when measuring it, as renal dysfunction can artificially inflate peripheral titers. The consensus conclusion was that a beta-2 microglobulin of at least 5.5 without renal failure should be considered high-risk but should not preclude detailed genomic profiling. So, in conclusion, the novel 2025 IMS-IMWG risk stratification system for myeloma is binary. It's either high-risk disease or standard-risk disease. It's got four criteria. Number one, deletion 17p and/or a TP53 mutation. Clonal cell fraction cut-off, remember, is 20%. Or number two, an IGH translocation - t(4;14), t(14;16), t(14;20) - with 1q gain and/or deletion of 1p. Or a monoallelic deletion of 1p with 1q additional copies or a biallelic deletion of 1p. Or a beta-2 microglobulin of at least 5.5 only when the creatinine is normal. This is a field-defining work that draws on analyses from across the world to put forward a dominant definition of high-risk disease and introduces a new era of biologically informed risk assessment in myeloma. Now, how does this change our clinical approach? FISH must be performed on CD138-enriched samples and should be performed for all patients. Next-generation sequencing should also be performed on all patients. Trials will hopefully now begin to include this novel definition of high-risk multiple myeloma. It does remain to be seen how data from novel therapeutic trials, if stratified according to this novel definition, will be interpreted. Will we find that therapies being evaluated at present have differential effects on myelomas with different genetic lesions? Other unanswered questions also exist. How do we go about integrating this into academic and then community clinical practice? How do we devise public health interventions for low-resource settings? To discuss this piece further, we welcome the esteemed Dr. Nikhil Munshi to the podcast. Dr. Munshi is a world-renowned leader in multiple myeloma and the corresponding author on this paper. As Professor of Medicine at Harvard Medical School, Director of the Multiple Myeloma Effector Cell Therapy Unit, and Director of Basic and Correlative Science at the Jerome Lipper Multiple Myeloma Center of the Dana-Farber Cancer Institute, he has presided over critical discoveries in the field.  Thank you for joining us, Dr. Munshi. Dr. Nikhil Munshi: Oh, it's my pleasure being here, Michael, to discuss this interesting and important publication. Michael Hughes: I had a few questions for you. So number one, this is a comprehensive, shall we say, monumental and wide-ranging definition for high-risk myeloma. How do you hope this will influence or impact the ways we discuss myeloma with patients in the exam room? And how do we make some of these components recommended, in particular next-generation sequencing, feasible in lower-resource settings? Dr. Nikhil Munshi: So those are two very important questions. Let's start with the first: How do we utilize this in our day-to-day patient care setting? So, as you know well, we have always tried to identify those patients who do not do so well with the current existing treatment. And for the last 30 years, what constitutes a myeloma of higher risk has continued to change with improvement in our treatment. The current definition basically centers around a quarter of the patients whose PFS is less than 2 to 3 years. And those would require some more involved therapeutic management. So that was a starting point of defining patients and the features. As we developed this consensus amongst ourselves - and it's titled as “International Myeloma Society, International Myeloma Working Group Consensus Recommendation” - this IMS-IMWG type of recommendation we have done for many years, improvising in various areas of myeloma care. Now, here, we looked at the data that was existing all across the globe, utilizing newer treatment and trying to identify that with these four-drug regimens, with transplant and some of the immunotherapy, which group of patients do not do as well. And this is where this current algorithm comes up. So before I answer your question straight, “How do we use it?” I might like to just suggest, “What are those features that we have identified?” There are four features which constitute high-risk disease in the newer definition. Those with deletion 17p with 20% clonality and/or TP53 mutation. Number two, patients with one of the translocations - t(4;14), t(14;16), or t(14;20) - co-occurring with 1q amplification or deletion 1p32. And that's a change. Previously, just the translocation was considered high-risk. Now we need a co-occurrence for it to be called high-risk. The third group is patients having biallelic deletion 1p32 or monoallelic deletion 1p32 along with 1q amplification. And finally, patients with high beta-2 microglobulin, more than or equal to 5.5 mg/dL, with normal creatinine less than 1.2 mg/dL. And the question, “How do we use this?” There are multiple areas where we incorporate high-risk features in our treatment algorithm. One of the first areas is where we would consider the induction regimen. If a patient has a high-risk disease, we would definitely consider a four-drug regimen rather than a three-drug regimen, although we are beginning to incorporate four-drug for all groups. That's one important thing. Number two, those are the patients where we do consider consolidation with transplant or maybe in the new world, considering some of the immunotherapeutic consolidation more early or more aggressively. Number three, these are the patients who get a little bit more maintenance therapy. So normally, lenalidomide might end up being our standard maintenance regimen. In patients who have high-risk disease, we incorporate either addition of daratumumab or the anti-CD38 targeting antibody and/or addition of proteasome inhibitor, either bortezomib or carfilzomib. So you would have multi-drug maintenance therapy in these patients. And in high-risk patients, we follow them with maintenance longer periods of time. One very critically important point to keep in mind is that to get the better outcome in high-risk disease, we must try to get them into MRD negativity because there is clear data that patients who do achieve MRD negativity, despite having high-risk disease, have a much superior outcome. They become near to standard-risk disease. And so, in high-risk patients, I would try to do whatever various options I have to try and get them into MRD-negative status. And when these patients relapse, we do not wait for the classic progression criteria to be met before we intervene. We would propose and suggest that we intervene earlier before the disease really blasts off. And so there are a number of areas in our setting where this high-risk definition will help us intervene appropriately and also with appropriate aggressiveness to achieve better outcome, to make this similar to standard-risk disease. Michael Hughes: Thank you, Dr. Munshi. And thoughts on how to really integrate this not only into academic centers but also lower-resource settings? Dr. Nikhil Munshi: So that's a very important question, Michael. And when we were developing this consensus, we were very cognizant of that fact. So wherever available, I think we are recommending that over a period of next 2, 3, 5 years, we should begin to switch over to sequencing-based methods because two components of this definition, one is TP53 mutation, which we cannot do without sequencing, and also reliably detecting deletion 1p requires sequencing-based method. So in the low-resource countries - and there are many in this world, and also even in our own country, patients may not be able to afford it - the older method with FISH or similar such technology, which is more affordable, is also acceptable for current time. They may miss a very small number of patients, maybe 2% to 3%, where these finer changes are not picked up, but a majority of this would be captured by them. So the current practice might still be applicable with some limitation in those patient populations, and that's what we would recommend. What is happening, fortunately, is that actually sequencing-based method is becoming cheaper. And in many centers, it is cheaper to do the sequencing rather than to do the FISH analysis. And so my hope is that even in low-resource centers, sequencing might be more economical in the end. It's, I think, the access to technology, which is a little bit limited currently, but it's hopefully becoming available soon. Michael Hughes: Thank you, Dr. Munshi. And staying for a minute and looking at the multiple myeloma subsets which might be missed by this really still very broad-ranging high-risk definition, at least by prior risk stratification systems, right, there is this group of patients who have standard-risk cytogenetics by R-ISS or R2-ISS, but they have primary refractory disease or they relapse early. We call these, as you are well aware, functionally high-risk disease. What proportion of previously FHR, functionally high-risk, myeloma patients do you expect to be captured by this novel definition? Dr. Nikhil Munshi: So I think the newer definition - and we can look at it both ways, but the newer definition should capture most of the functionally high-risk definition. To put it differently, Michael, there are patients who we know are, as you mentioned, functionally high-risk. Those are the patients who might have plasma cell leukemia, those who might have extramedullary disease, those who might not respond to our four-drug induction. If you don't respond to the four-drug induction, almost by definition, they are high-risk. However, a majority of them have one of the abnormalities that we are describing here. There would be a very small proportion which may not have. And if they do not have, we know one of the important components of this definition here is also that the genome, we know, keeps on evolving. So there may be a very small clone with the high-risk feature which was not obvious in the beginning. Following treatments or following relapse, that clone predominates, and now the patient's disease becomes high-risk.  So the definition would incorporate or would capture these functional high-risk patients, but as you said, in countries where resources are not available, using this functional high-risk would also be helpful and advantageous. Sometimes LDH ends up being a high-risk. In our studies, LDH has not come out to be high-risk anymore because the features we are describing captures most of those patients, but those alternatives, older, can still be considered if other newer techniques are not available. Michael Hughes: Got you. And in terms of these older definitions, yes, that incorporate tumor burden, these empirical observations about how myeloma presents, do you foresee any additional tumor burden indicators being added to future definitions of high-risk disease? Or do you instead see this particular definition as a major waypoint on the journey towards a fully biologically grounded definition of high-risk disease? Dr. Nikhil Munshi: I think your second part is what is going to happen. I think the tumor burden-related definition is being now replaced by the biological or genomic-based definition. And I think at some point, it will be quite fully replaced. One component not here, and it is because one thing, we don't have enough data; number two, we don't know how it will pan out, is also the influence of the microenvironment on the risk definition. For example, the immune system, the immune function, etc. But not enough data exists to suggest how it would change the current definition. So in future, would a definition be totally genomic or it could be more integrative? And my personal guess is that it would be more integrative and that some immune features might come into the picture, especially now that we are using immune-based therapy as a very important component of treatment - CAR T-cells, bispecific, and antibody-based treatments. What role the immune system plays in either supporting tumor or what role suppression of the anti-tumor immunity plays? They all will be important how patient outcomes end up being, and which in turn could translate into how patient's risk stratification might happen. So I think the older tumor burden-related definitions probably will become things of the past. What we have currently proposed and consensus developed is the new path forward, and over time, some microenvironmental influences, if defined and found to be important, may get some more incorporation if it compares favorably with the genomic features. Michael Hughes: Thank you, Dr. Munshi for that enlightening response.  To conclude the podcast, I'd like to look to the future and to the immediate future, what are the next steps for high-risk disease definition between now and discussing an integrated genomic-microenvironment-based definition? Will we see attempts to refine? Will we see a multi-level system, things like this? Dr. Nikhil Munshi: Yeah, so I think the current definition will be here to stay for the next 10 years or so. I think this has been developed using a large amount of data, so we do believe that this will remain fine. It has been validated now within the last six months by a few of the other studies. So there won't be a quick change. But we will try to, all of us will try to innovate. And as you very rightly bring up, the areas of research would include looking at the expression or transcriptomic component. Does that matter? And we do believe a small number of patients will have transcriptomic changes, not looked at the DNA changes, and may play a role. There are newer components, so long non-coding RNA, for example, is going to be an important component to look at, how it impacts the disease outcome, etc. There are also some of the proteomic-related changes which may become important in our studies. And then as we discussed, microenvironment and immunological changes. So these are the future areas of ongoing research where we all should collect data, and then in the next 5 to 10 years, we'll have another group meeting to see has anything changed or any of the features have become more important.  Most of the time, some of the older features are lost because they are not as critically high-risk, and the newer features come in. And so the historical background for just one second, there was a time when chromosome 13 was considered a high-risk disease. We now don't even mention it because it's not high-risk. The newer treatments have improved the outcome. t(4;14) used to be a high-risk disease. Now by itself today, in this definition by itself is not; it needs to be with something else. And so I think this is a great sign of progress. As we improve the treatment and outcomes, some of the features will become less important, new features will come up, and we'll need to keep on evolving with time and with technology and make it better for patients. Michael Hughes: Thank you so much, Dr. Munshi, for your wisdom, for your sagacity, for your historical perspective as well.  Thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries. And be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

How does a wealthy animal welfare organisation, funded by well-meaning donors from Europe and North America, end up relocating hundreds of elephants to an area where some of the world's poorest people live? What happens when two people are killed within 24 hours of the first four elephants arriving, yet the organisation presses on with moving another 259 elephants in just 30 days? Why are over 12,500 people now living in terror whilst those responsible show nothing but arrogance when approached for help?This episode examines a conservation crisis unfolding in Malawi and Zambia, where the International Fund for Animal Welfare's elephant translocation project has gone catastrophically wrong. Journalist Jens Ulrik Høgh returns from his recent trip to the region, where he documented the devastating impact on local communities who had never seen elephants before 2022. Twelve people have been killed, thousands have lost their crops and livelihoods, and children can no longer safely walk to school. Meanwhile, the elephants themselves are being killed in retaliation, making this a disaster for both wildlife and people.The conversation explores uncomfortable questions about conservation imperialism, the business models of large NGOs, and the stark inequality between wealthy Western donors and the African communities bearing the consequences. Jens reveals how a project that cost less than $2 million has destroyed lives whilst the organisation continues to raise over $100 million annually. This isn't just about elephants - it's about power, money, and the ongoing legacy of colonial attitudes in modern conservation. The episode serves as a crucial reminder that conservation projects are doomed to fail without local acceptance, often with tragic consequences for all involved.Further reading:In Rural Malawi, a Western NGO Imported Elephants. Chaos Ensued.Subscribe to Tommy's Outdoors: Conservation and Science NewsletterSupport the Podcast and Buy Me a Coffee.Recommended Books: tommysoutdoors.com/booksMerch: tommysoutdoors.com/shopFollow Tommy's Outdoors on Bluesky, Twitter, Instagram, YouTube and Facebook

Today on Our Changing World – we have a piece from the archives – from 15 years ago. Chatham Island tūī once were common on the main Chatham Island, but from the 1930s their numbers started to decline, and by the 1990s they were all but gone. In 2009 fourteen tūī were transferred from nearby predator free Rangatira island to the main island. They all survived the winter, and some started to breed. Following up on this success, local conservation group the Chatham Island Taiko Trust decided to translocate more in 2010. We join Alison Ballance and the tūī team just after they've caught and contained 40 birds.

One from the archives! By the 1990s Chatham Island tūī had all but disappeared from the main island. Slightly different to their mainland counterparts, these songbirds had survived on nearby Pitt and Rangatira islands. So a local conservation group decided to try bring them back. In this episode from 2010, Alison Ballance joins the ‘tūī team' tasked with moving 40 birds from Rangatira island back to the main island. From now on Our Changing World will arrive in your podcast feed first thing on a Tuesday morning!Sign up to the Our Changing World monthly newsletter for episode backstories, science analysis and more.In this episode:00:00 – 02:30 Introduction and background info02:30 – 12:14 Catching tūī on Rangatira Island12:15 – 12:24 Team has caught 40 birds12:25 – 24:46 Moving the birds to main Chatham Island24:47 – 25:55 Update on the birds…Go to this episode on rnz.co.nz for more details

In this episode, we discuss the relationship between the intestinal mucus layer and secretory immunoglobulin A (sIgA), highlighting both as key components of the gut's first line of defense against pathogens, toxins, and environmental stressors. We detail how dysbiosis and microbial overgrowths can impact sIgA levels and can disrupt mucus integrity and function, contributing to increased intestinal permeability and inflammation. We then examine several additional factors influencing sIgA production. Topics: 1. Introduction: Importance of Secretory IgA and Intestinal Mucus     - Intestinal epithelial lining and its protective mucus layer     - Focus on intestinal dysbiosis and sIgA   2. Anatomy of the Gastrointestinal Lining     - Intestinal lumen, microbiome, mucus layer, epithelial cells, tight junctions, lamina propria, and smooth muscle     - Role of goblet cells in mucus secretion and epithelial integrity    3. Role of the Protective Mucus Layer     - Dual function of the mucus layer as a physical and biochemical barrier     - Composition of mucus: mucins, antimicrobial peptides, immunoglobulins    4. Goblet Cells and Mucin Production     - Mechanisms of mucin secretion and hydration     - Variability in goblet cell density across the intestinal tract     - Dysfunctions linked to conditions like IBD and IBS    5. Microbial Interactions with Mucins     - Glycan structures in mucins    - Roles of commensal and pathogenic bacteria in mucin degradation and mucus turnover     - Importance of regulated mucus production for gut homeostasis    6. Dysbiosis and Mucus Degradation     - Excessive mucin degradation leading to thinning of the mucus layer     - Consequences of increased intestinal permeability and inflammation     - Role of dysbiosis in disrupting the mucus layer    7. Overview of Secretory IgA     - Introduction to secretory IgA (sIgA) and its role in mucosal immunity    - Mechanisms of immune exclusion and pathogen neutralization    8. Production and Function of Secretory IgA     - sIgA production by plasma cells in the lamina propria     - Translocation of IgA through epithelial cells into the gut lumen     - sIgA binding to mucins and its immunological role in the mucus layer    9. Factors Affecting Secretory IgA Levels     - Possible contributing factors to low sIgA levels    - Implications of low and high sIgA levels for immune defense and intestinal health    10. Interactions Between Secretory IgA and Dysbiosis     - Cyclical relationship between low sIgA, dysbiosis, and infections     - Examples of overgrowths, like candida, disrupting sIgA     - Importance of addressing immune dysregulation to break the cycle    11. Bioindividual Root Cause Approach  - Factors to consider Thank you to our episode sponsors: 1. Shop ⁠⁠Fresh Press Farms⁠⁠' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection ⁠⁠here⁠⁠. 2. Check out ⁠Spectrum Sciences⁠' Serums and The Vitamin B12 Protocol ⁠here⁠, and use code CHLOE15 for 15% off. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

What is the root cause of your addiction? After two years of not touching alcohol, Danny shares his recent experiments with introducing the occasional alcoholic beverage back into his life. This podcast focuses on how we can often translocate energies from one addiction to another as we heal and make different life choices.  The Masters of Self University PODCAST is your highest source of Sacred Truth and Universal Wisdom, offered by Rachel Fiori, mystical teacher, psycho-energetic healer, & CEO. Join our journey of soul transformation with hosts Ellie Lee, Danny Morley, and the rest of our amazing Certified Mystical Life Coaches. Student Enrollment:   https://www.mastersofselfuniversity.com/university-enrollment Rachel's Book on Amazon:   ⁠https://shorturl.at/hkyLR Join Our Free Discord Community:   https://www.mastersofselfuniversity.com/resources#discord Masters of Self University:   ⁠⁠⁠⁠⁠https://mastersofselfuniversity.com/ Ellie's Social Media:   ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@ellieyjlee⁠⁠⁠⁠   ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/ellieyjlee⁠⁠⁠⁠ Danny's Social Media:   ⁠⁠⁠⁠https://www.instagram.com/dannyfmorley   ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@dannyfmorley   www.youtube.com/@DannyfMorley NEW EPISODES EVERY MONDAY AND THURSDAY!

I've spent some time reflecting back on all my years practicing in hospitals, often not sleeping for extended periods, sometimes days, covering hospitals floors and ICUs, resuscitating people who experienced cardiac arrests, taking them to the cath lab to open arteries, but also witnessing people with all sorts of other health conditions: cancers, wound infections, sepsis, delirium, the various stages of dementia, and hundreds of other debilitating disease. I now recognize that, looking back, so many health conditions can be better understood in light of the contribution of the microbiome, i.e., the trillions of microbes occupying the gastrointestinal tract from mouth to anus, the nasal sinuses, the airways, the brain, the prostate, the vagina and uterus, the skin—virtually every part of the human body. We all know about acute bacterial infections. But I'm talking about something different. While microbes exert effects via a number of different routes—think the gut-brain axis, the gut-skin axis, the gut-muscle axis, effects exerted via hormones, inflammatory mediating proteins, and bacterial breakdown products. But beyond this, there is a curious phenomenon in which bacteria and fungi themselves, by a number of means, travel through the body to take up residence and cause trouble. But the “trouble” is not an infection in the conventional sense, but something different, less acute, less urgent, less dramatic, but nonetheless playing a big role in your health. This is the fascinating and scary phenomenon called “translocation,” the topic for this episode of the Defiant Health podcast. _______________________________________________________________________________For BiotiQuest probiotics including Sugar Shift, go here.A 15% discount is available for Defiant Health podcast listeners by entering discount code UNDOC15 (case-sensitive) at checkout.*_________________________________________________________________________________Get your 15% Paleovalley discount on fermented grass-fed beef sticks, Bone Broth Collagen, low-carb snack bars and other high-quality organic foods here.* For 12% off every order of grass-fed and pasture-raised meats from Wild Pastures, go here._____________________________________________________________________________MyReuteri and Gut to Glow can be found here: oxiceutics.comSupport the showBooks: Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded ed

In July 2023 four male kākāpō were released into the fenced Sanctuary Mountain Maungatautari – part of a new habitat trial to investigate suitable locations for the growing kākāpō population. But after a further six were introduced, the kākāpō began to wander – beyond the fence. A year on, and several escapes later, what's been learned? And what's next for kākāpō in Maungatautari?  

Following the botched relocation of 263 elephants in Malawi, 10 people have died. Damages to small scale farming communities estimate in the region of $3 million. Ed Stoddard weighs in. See omnystudio.com/listener for privacy information.

In this final episode of the series, presenter Gordon Buchanan heads home to Scotland to see the work that the Beaver Trust is leading to “regenerate the beaver species to regenerate the landscape”.The Beaver Trust is a charity working to restore animals to habitats where they thrived in the past, building climate resilient landscapes across the UK and we speak to Elliot McCandless from the charity. We also chat to Tom, a fifth-generation farmer on the land but with a very different role to his predecessors.Our conversations take place, thousands of miles away from the baobab – but with similar ambitions, challenges and conflicts to navigate.We spoke to both Elliot and Tom alongside the mud banks of a beaver lake, home to the second family of beavers that were brought to Tom's land in February 2022. Translocation and reintroduction of the species in Scotland brings its own controversies with conservationists, farmers, government and local people holding different perspectives on the beaver population as we'll explore in this episode.Whilst this is the last episode of series 2, we will be publishing a special bonus edition of Beneath The Baobab in the coming weeks, bringing together all the key points and fascinating conversations from the last 9 programmes.So please follow, like or subscribe to make sure you don't miss it – and leave a written review if you've enjoyed the series; it'll help more people join us in our global conversation, beneath the baobab.Visit the website https://jammainternational.com to explore more international projects.The video of this episode can be seen here: https://youtu.be/5FOfzoGgy48https://beavertrust.orghttps://beavertrust.org/nature-boost-in-perthshire-as-second-group-of-beavers-moved-to-argaty/https://www.nature.scot Hosted on Acast. See acast.com/privacy for more information.

Just as Montana, Idaho and Wyoming politicians prepared to sign a three-state agreement on grizzly bear management, grizzly protection advocates sent a warning they plan to sue over a crucial part of the states’ plan. They don’t like the idea of trucking grizzlies from one recovery area to another as a solution to the bears’ genetic diversity. Grizzly bears remain a threatened species under federal Endangered Species Act protection. State wildlife officials say the bears are recovered and should be turned over to local state management. Grizzly defenders counter that will open the door for trophy hunting and unsustainable predator shooting. It would also put grizzlies in conflict with a different kind of advocate – black bear hunters. On this episode, Rob Chaney, Lee Montana's statewide enterprise editor and author of 'Grizzly in the Driveway' makes sense of recent grizzly bear related headlines.

As the climate changes, many species may have to relocate to survive - including the Pygmy Blue-Tongue Lizard which is receiving some assistance from scientists in South Australia.

This is the first installment of a miniseries about amphibian conservation and determination. We're calling the miniseries For the Frogs. In each episode, we will meet to one native amphibian that can be found in California's national forests. These creatures are important to ecological health, and once we get to know them, they can deepen our connections with public lands. But each of these species is in a state of decline due to overlapping threats, including pathogens, introduced predators, habitat loss, drought and wildfire. Fortunately, there is a village of specialists devoted to conserving these species despite the colossal challenge of the threat supergroup. The stories of their resolute conservation efforts, pursued through obstacles and setbacks, provides portraits of determination that we can pocket and apply to our own personal experiences with adversity. For a transcript, click here.

On this episode of Say Something Interesting Brent and Megan discuss last weekend's talk at EastLake. Other topics include @scotthepainter, whole person ministry, and cancelled flights.

The most important Gift I can give you this Christmas Season is Expectation: the strong belief that a Miracle WILL Happen. Merry Christmas!A personal collection of stories. You will laugh (Spiritual Woo Woo) cry (Kleenex Box Episode), and witness the wonder and awe of God.  Baptism of Holy Spirit Prayer Language  & Healing Fear of man, Fear of God Standing in the Glory of God Translocation and Bi-location Spiritual Vehicle and Spiritual DNA electrostatic attraction Special Song at the End Colossians 1:20 He initiated the reconciliation of all things to himself. Through the blood of the cross, God restored the original harmony. His reign of peace now extends to every visible thing upon the earth as well as those invisible things which are in heavenly realm. “Not only that but all the broken and dislocated pieces of the universe, people and things, animals and atoms, get properly fixed and fit together in vibrant harmonies, all because of his death.” — The Message.)INTENTIONAL NOW SHOW NOTES 2024 INP LISTENER SURVEY AND RAFFLE (ENTER TO WIN)INTENTIONAL NOW FB COMMUNITY   Connect with Kristen onInstagram #intentionalnowpodcast. Twitter Linkedin Patreon thank you for your support of this Podcast Website KristenWambach.comBest Resource: Kristen's #1 Money and Time-Saving ToolThank you for spending this time with me, I am honored. See you next week Kristen Music Credits  by Stockaudios from Pixabay  

The most important Gift I can give you this Christmas Season is Expectation: the strong belief that a Miracle WILL Happen. Merry Christmas!A personal collection of stories. You will laugh (Spiritual Woo Woo) cry (Kleenex Box Episode), and witness the wonder and awe of God.  Baptism of Holy Spirit Prayer Language  & Healing Fear of man, Fear of God Standing in the Glory of God Translocation and Bi-location Spiritual Vehicle and Spiritual DNA electrostatic attraction Special Song at the End Colossians 1:20 He initiated the reconciliation of all things to himself. Through the blood of the cross, God restored the original harmony. His reign of peace now extends to every visible thing upon the earth as well as those invisible things which are in heavenly realm. “Not only that but all the broken and dislocated pieces of the universe, people and things, animals and atoms, get properly fixed and fit together in vibrant harmonies, all because of his death.” — The Message.)INTENTIONAL NOW SHOW NOTES 2024 INP LISTENER SURVEY AND RAFFLE (ENTER TO WIN)INTENTIONAL NOW FB COMMUNITY   Connect with Kristen onInstagram #intentionalnowpodcast. Twitter Linkedin Patreon thank you for your support of this Podcast Website KristenWambach.comBest Resource: Kristen's #1 Money and Time-Saving ToolThank you for spending this time with me, I am honored. See you next week Kristen Music Credits  by Stockaudios from Pixabay  

Have you ever wondered what would happen if we could use natural teeth instead of implants? Like, could we gently extract a 3rd molar and move it up in place of an extracted 1st molar? Listen to this fascinating Fast Fact with Katrina Sanders! Resources:More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/ Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/  Pini Prato, G., Franceschi, D., Pace, R., & Di Gianfilippo, R. Translational approach to tooth autotransplantation: A 27‐year case study. Clinical Advances in Periodontics.

Have you ever wondered what would happen if we could use natural teeth instead of implants? Like, could we gently extract a 3rd molar and move it up in place of an extracted 1st molar? Listen to this fascinating Fast Fact with Katrina Sanders! Resources:More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/ Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/  Pini Prato, G., Franceschi, D., Pace, R., & Di Gianfilippo, R. Translational approach to tooth autotransplantation: A 27‐year case study. Clinical Advances in Periodontics.

In this episode, we discuss the consequences of moving problem critters around on the landscape, and reasons why wildlife biologists do not recommend translocation of wildlife as a humane option when removal is needed.

In this episode, we discuss the consequences of moving problem critters around on the landscape, and reasons why wildlife biologists do not recommend translocation of wildlife as a humane option when removal is needed.  

This Part 4 Listening is all about moving elephants. In the lesson you'll learn about: using word prompts to keep your place using intonation and sentence stress to identify answers using spelling patterns and plurals to get the right answers The full transcript is available in the Bronze Membership on my website. https://ieltsetc.com/2023/10/ielts-listening-part-4-keeping-up-with-the-speaker/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/ieltsetc/message

References Molecular Neurobiology 2022. volume 59, pages 4223–4241 Hum Genet. 1994 Jan;93(1):67-73 Mol Cell Biol. 2012 Jan;32(1):126-38 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

It's been around 2 months since the first translocation of kākāpō to mainland Aotearoa. To check in on how these taonga are going in Te Ika a Māui, we're joined by Ngai Tahu kākāpō recovery group representative, Tāne Davis. 

References Journal of Immunology Research Article ID 8263829 JAMA. 2021 Jun 15; 325(23): 2392–2393. Thyroid. 2014 Feb 1; 24(2): 371–382. Pol Arch Intern Med. 2022 Mar 30; 132(3): 16222. FEBS Letters.1997. (414): 258-262 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Cleveland native Justin Telep loves to fish. It makes sense then that he loves his job as a Field Biologist at the Sewer District. Justin and his team study the health of aquatic organisms in area streams to determine water quality. He talks about a NEORSD project to re-introduce native fish into a once-polluted Plum Creek. We also discuss fishing opportunities on Lake Erie ("the walleye capital of the world") and Justin shares an easy recipe for crispy fish tacos.Some acronyms used in this episode:IBI: Index of Biotic Integrity, an indicator of the health of a fish communityMIwb: Modified Index of Well-Being, another method of determining the health of the fish communityICI: Invertebrate Community Index, which measures the health of bugs in the stream

What methods could be employed after a massive mule deer population die-off?     Below are some options biologists generally turn to try and help any population: Habitat Restoration, Disease Monitoring and Control, Wildlife Population Monitoring, Conservation Breeding and Translocation, Public Awareness, and Education, Collaboration, and Partnerships.   Music from #Uppbeat (free for Creators!): https://uppbeat.io/t/paul-yudin/your-adrenaline License code: QWS1TG5BYTFK2PCL

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.05.547674v1?rss=1 Authors: Demirbas, B., Filina, O., Louisse, T., Goos, Y., Sanchez-Romero, M. A., Olmedo, M., van Zon, J. Abstract: FOXO transcription factors are highly conserved effectors of insulin and insulin-like growth factor signaling, that are crucial for mounting responses to a broad range of stresses. Key signaling step is the stress-induced translocation of FOXO proteins to the nucleus, where they induce expression of stress response genes. Insulin signaling and FOXO proteins often control responses that impact the entire organism, such as growth or starvation-induced developmental arrest, but how body-wide coordination is achieved is poorly understood. Here, we leverage the small size of the nematode C. elegans, to quantify translocation dynamics of DAF-16, the sole C. elegans FOXO transcription factor, with single-cell resolution, yet in a body-wide manner. Surprisingly, when we exposed individual animals to constant levels of stress that cause larval developmental arrest, DAF-16/FOXO translocated between the nucleus and cytoplasm in stochastic pulses. Even though the occurrence of translocation pulses was random, they nevertheless exhibited striking synchronization between cells throughout the body. DAF-16/FOXO pulse dynamics were strongly linked to body-wide growth, with isolated translocation pulses causing transient reduction of growth and full growth arrest observed only when pulses were of sufficiently high frequency or duration. Finally, we observed translocation pulses of FOXO3A in mammalian cells under nutrient stress. The link between DAF-16/FOXO pulses and growth provides a rationale for their synchrony, as uniform proportions are only maintained when growth and, hence, pulse dynamics are tightly coordinated between all cells. Long-range synchronization of FOXO translocation dynamics might therefore be integral also to growth control in more complex animals. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

India's ambitious cheetah relocation project got a shot in the arm when one of the translocated females gave birth to four cubs in March. These were the first cheetah cubs to be born in India since the species went extinct in the country 70 years ago. But in an unfortunate turn of events, three out of the four cubs have died, and the fourth one, also reported to be very weak, is under close medical monitoring. The Environment Ministry in a press release has claimed that the survival rate of cheetah cubs is only 10%. Does that mean that the deaths of the three cheetah cubs were along expected lines? Shouldn't the survival rate be higher in the absence of predators? What are the various factors that could have a bearing on the survival of cheetah cubs? 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.03.535309v1?rss=1 Authors: Peh, A., Dinakis, E., Nakai, M., Muralitharan, R. R., Rupasinghe, S., Wilson, J. L., Wong, C. H. Y., Jama, H., Barker, C. M. O., Modarresi, M., Kemp-Harper, B. K., Zheng, T., Marques, F. Z., Broughton, B. R. S. Abstract: We provide evidence that stroke-induced gut breakdown results in bacteria translocation to the ischaemic mouse brain. Inhibition of sympathetic tone reduced bacterial load in the post-stroke brain and reduced functional deficits without altering cerebral apoptosis, neuroinflammation or infarct volume. These findings indicate that the activation of the sympathetic nervous system after stroke promotes gut-derived bacteria to enter to the brain, and this process worsens motor function in mice. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In a meta-analysis of six eligible studies, results validated that periodontitis was significantly associated with IBD, but the mechanism was still undetermined. by Anne O. Rice, BS, RDH, CDP, FAAOSH   Read Article Here: https://www.rdhmag.com/patient-care/patient-education/article/14284883/the-translocation-of-bacteria-inflammatory-bowel-disease 

Brought to you by Community-Minded Alpine Toyota   In the episode Mark and Curtis talk turkey with Matt Besko, Director of Wildlife and Licensing for the province of Alberta. The topics they cover include the moving wild turkey from BC to Alberta, the difference in attitudes towards managing wild turkey in BC versus Alberta, the philosophy of non native wild turkeys in an altered landscape, valuing wild turkeys, wild turkey-human conflict, myths about wild turkey, adaptive management, Alberta's wild turkey Minister tags, hunting wild turkey, iconic hunting cocktails to represent the regions of Canada and gator tails.

Translocation and the reintroduction of beavers are valuable resources in restoring areas that have experienced drought or abuse. Another option is beavery mimicry, using beaver tactics through a series of small rock dams, sod mats, and woven willows to mimic a beaver dam. There are pros and cons to these solutions: Translocating beaver are a lot cheaper than beaver mimicry but beaver tend to build wherever they want.   Music from #Uppbeat (free for Creators!): https://uppbeat.io/t/paul-yudin/your-adrenaline License code: QWS1TG5BYTFK2PCL

Reference Alcohol Clin Exp Res. 2011 Aug; 35(8): 1435–1444 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this episode, Prof. Van de Heyning shares 3 harmful results which could occur when an electrode is inserted into the cochlea and how we can prevent it. He also discusses why straight electrodes are a suitable and preferable choice for robotic and CI surgery.

The differences between the two main types of cochlear implant electrode arrays are explained in this episode by Dr. Hans Thomeer. Specifically, how these two electrode designs and surgical approaches can affect translocation after the electrode insertion, and what might be a better option.

Today I am joined by Christina as she shares her story with miscarriages, genetic testing, IVF, and more. Christina has been so strong and has handled her struggles with complete grace. I'm sure that this episode will help someone out there who has gone through or is currently experiencing a similar situation. Please remember that neither of us are doctors or medical specialists. Please consult your doctor your individual health. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

This is perhaps the most important podcast I've recorded so far, because it deals with a topic that is becoming increasingly relevant with the growing popularity of psychedelics, occult practices and technology.On this episode I speak with Norwegian healer and author Are Thoresen about his 2020 book Demons and Healing: The Reality of the Demonic Threat and the Doppelgänger in the Light of Anthroposophy: Demonology, Christology and Medicine.Are Thoresen was born in Norway in 1952. A doctor of veterinary medicine, he has also studied anthroposophic medicine, homeopathy, acupuncture, osteopathy and agriculture. Since 1981 he has run a private holistic practice in Sandefjord, Norway, for the healing of small animals and horses, as well as people. He has lectured widely, specializing in veterinary acupuncture, and has published dozens of scholarly articles. In 1984 he started to treat cancer patients, both human and animals, and this work has been the focus of much of his recent research. He is the author of Demons and Healing and several other books on complementary medicine.In our conversation Are and I discuss many aspects of demonic entities and possession — how they are created, how they cause physical and mental disease, and how we can transform them and protect ourselves from them. In his books Are writes in great detail about these entities, and trust me, it can begin to feel pretty complex and overwhelming. In an attempt to keep this conversation grounded and relatable, I thought it would be helpful if I shared my personal experience with a demonic entity that I encountered while experimenting with astral projection as a teenager, and how I dealt with it 20 years later in the Santo Daime ayahuasca church. This experience is something that I've only talked about with 2 or 3 people over the years, and while I'm a little reluctant to share it publicly, I feel that it could actually save someone's life. It's that important.•••Timestamps4:20 Introduction8:22 Early spiritual life (Anthroposophy, spirits, Christianity)13:10 Demons, entities, psychedelics & disease16:35 Possession & translocation of entities20:40 Guarding against opening portals21:40 My experience with a demonic entity28:50 Are diagnoses my opening29:57 Closing portals32:00 Types of entities & disease38:49 Different types of attacks40:25 Ayahuasca and opening portals42:20 Protecting yourself in ceremony45:00 Translocation vs. Transformation of entities46:10 Strengthening the “I”53:16 The protective power of music 53:56 The dangers of technology57:30 Memory of water & homeopathy58:49 What psychedelic “therapy” is getting wrong1:02:15 “Opening the middle” in electronic devices and in healing work1:13:40 What changed after Christ 1:16:36 The need for spiritual warriors and spiritual healing•••Support the Podcast!If you'd like to join the conversation and help support the podcast, please considering becoming a member of the growing Medicine Path tribe at patreon.com/medicinepath. You can also follow me on Instagram @revealingthesoul. I love hearing from listeners, so please feel free to reach out on social media or email me at hello@brianjames.ca•••Links:Donate: http://ko-fi.com/brianjames / http://paypal.me/medicinepathyogaPatreon: http://patreon.com/medicinepath Coaching & Books: http://brianjames.ca Yoga Courses: http://medicinepathyoga.comMusic: Royal Fern by Green House (https://green-house.bandcamp.com) See acast.com/privacy for privacy and opt-out information.

This week, Nathan talks about some great plants are blooming in his landscape this week! You might be seeing some plants, particularly gardenias, revealing some yellow foliage. Most folks think that yellowing leaves means the plant is dying, but Nathan says it's quite the opposite. Certain yellow leaves means that the plant is actually growing! Lastly, if you have some overgrown shrubs or trees, Nathan explains how you can rejuvenate them and "start them over."

Adolescent and Young Adult (AYA) Oncology Focusing on Translocation RCC Co-Host: Nick G. Cost, MD Outline: Topic 1: Adolescents with cancer are different from both children and older adults with cancer Topic 2: Differences in biology Topic 3: Differences in clinical behavior Topic 4: Specific clinical trial options Topic 5: Summary – “Now what? What should I do the next time I see an AYA with kidney cancer?”

In this week's episode we chat to Fiona. She found out she had inherited a Robertsonian Translocation from her father and suffered 3 miscarriages. She was in the process of starting IVF when she found out she was pregnant with her now 10 month old daughter.  --------------------------------Thanks for listening to the podcast. Please don't forget to subscribe, rate, review and share.Visit our website where you can find out a bit about us, read the blog and even 'purch our merch' via the online shop!Find out more about our courses including  THE PATHWAY TO RECOVERY which is designed to support, nuture and empower you following the loss of a baby. Our September course is now sold out but keep you eyes peeled for details about the October PTR as well as the new Pregnancy After Loss and Trying To Conceive courses.Contact us via social media platforms or email info@theworstgirlgangever.co.ukYou'll find us on...FacebookInstagramTwitteror you can join the TWGGE Facebook Support GroupIt's time to break the silence and open up the dialogue around the topics of miscarriage and pregnancy loss. No more shame, no more taboo, lets ditch it for our children; the ones that will come, the ones that are and the ones that never came to be.--------------------------------

Traci McCombs is a seasoned analyst at the NIH and an active-duty Army Spouse. After back-to-back miscarriages and the discovery of balanced Robertsonian translocation and cancer, she naturally conceived and gave birth to a daughter and later a son. Buy Traci's book "My Miscarriage" HERE Follow Traci: @tracidmccombs Follow Arden: @ardenmcartrette Follow TMD: @themiscarriagedoula` Interested in sharing your story? CLICK HERE The miscarriage doula is a service and resource for women and couples who are going through miscarriage or navigating life afterward. My approach is to help you identify healthy coping strategies, be a safe place for you to discuss what you've been through, and provide resources and education to help you as you move forward in your journey. Learn more HERE --- Send in a voice message: https://anchor.fm/arden-cartrette/message Support this podcast: https://anchor.fm/arden-cartrette/support

In this weeks episode Martin and Paul cover the translocation of large groups of people from big government states like California and New York to smaller government states like Texas and Florida. They cover what they suspect is the reason for the migration and what needs to happen so that new new digs don't turn…

In this episode we discuss basic information about being a Balanced Translation carrier and share our experience about our journey so far. We talk about our discovery of unbalanced translocation chromosomes on our miscarriage tissue and where that has lead us to now. Trigger warnings: miscarriages mentioned. Email us comments at: balancedtranslocationpodcast@gmail.com

Arden chats with her friend Steffi about recurrent pregnancy loss, when miscarriage is the reason for an infertility diagnosis, and how OCD (obsessive-compulsive disorder) can be triggered during a fertility journey and then motherhood after. In this episode, we hear Steffi's story through two miscarriages, a balanced translocation diagnosis (and what that means), having to do IVF to make a baby, and then her. scary first trimester with her double rainbow, Junie. *Support The Miscarriage Doula Podcast for as low as $0.99/month! Click here to learn more. Follow Arden: @ardenmcartrette Follow TMD: @themiscarriagedoula Visit themiscarriagedoula.co for information on private and group support services if you're going through loss or struggling with grief. --- Send in a voice message: https://anchor.fm/arden-cartrette/message Support this podcast: https://anchor.fm/arden-cartrette/support

What's the science behind beaver translocation? And why should it form part of an positive management strategy? As part of our content to celebrate British Science Week and International Women's Day, we talk to top beaver ecologist Dr Roisin Campbell-Palmer. With an impressive career and background in animal management and welfare, field operations and beaver/human conflict management, Roisin imparts heaps of knowledge and wisdom when it comes to bringing these mammals back to British rivers safely, and responsibly.  Coming up: Eva hits Sophie with an epic #FactOff, and brains are teased in another quiz! For more information on eco anxiety and professional advice, please click here. Are you a beaver believer? We want to hear from you: Beaver Trust.  Want more beaver? Please leave us a lovely little review, so we can bring the joy of beavers to more ears!  Hosted by Sophie Pavelle and Eva Bishop.  Produced and edited by Emma Brisdion.

This episode of the Ground Shots Podcast is a conversation between Kelly Moody and Gabe Crawford.   We haven't done an episode together since we were on the Colorado Trail this past summer. So, we wanted to talk about the research we have been doing since we got off of the trail, and while hermiting a bit in our bell tent camp along a riparian corridor, outside of Durango, Colorado. We've been thinking a lot about what land tending means, and definitions of ‘wildness,' and ‘wilderness' since hiking the trail, and wanted to spend some time looking into the literature out there on conservation, ecology and agriculture. We've only touched the surface with our research, but wanted to talk about it on air with ya'll here, and connect some distant tendrils of what we're finding through conversation. Above all, our goal has been to try to understand why anthropogenic (human tended and co-created) landscapes are ignored in scientific literature, hence why ‘wild-tending' seems far-fetched to some folks. And, we want to understand the deeper origins of the invasion biology field of conversation and how it may be connected to ethnocentrism, racism, unexamined colonialist assumptions in the fields of history and science, and more. Since this episode was recorded and edited, we have migrated to where my family is in southern Virginia for the rest of the winter and are trying to adjust to a different culture, climate and navigating the pandemic without public land.   In this episode of the podcast, we talk about:   the oppressive colonizing force of the Christian church institution in Europe and how this influenced the suppression of land based spirituality some etymology of ‘heretic,' ‘heathen,' ‘villan,' and ‘pagan' how the disregard for historic anthropogenic landscapes is connected to the obsession with ‘pristine' ecology and ‘wilderness' notions how Eurocentric ideas about agriculture influenced what colonists saw as ‘uncivilized' or ‘cultivated' on turtle island and how these ethnocentric biases ignored anthropogenic landscapes the white supremacy inherent in the western scientific interpretation of human cultivation, land management and indigenous influence on ecology biases in the historical accounts of indigenous cultures and the landscapes of Turtle Island, South America, etc. by European explorers yet many of these accounts are used to determine ecological baselines in conservation goals some of the origins of emotive, moral and value based language in invasive biology and conservation fields the roots of why conservationism is wary to include indigenous peoples in its preservation of ‘pristine wilderness' and how the creation of baselines that doesn't include indigenous land management practices, even though the ecological baselines that might be their goals were anthropogenic landscapes the history of national parks extirpating natives off of their land in order to ‘preserve' an idea of ‘wilderness' and how they continue to ignore how the humans there were a part of creating and managing the landscapes the affluence associated with conservation culture and the western ideas of the museumification of ‘pristine land' the misinformation in the academic literature of invasion biology created through confirmation biases and disproven theories continuing to be referenced as facts   Links: A slew of resources related to what we chatted about on the podcast can be found below. Subscribe to our email newsletter, found at the bottom of this link section, for updates on when we will be offering some classes related to these topics. “Rambunctious Garden : Saving Nature in a Post-Wild World” by Emma Marris “Beyond the War on Invasive Species” by Tao Orion “Keeping it Living: : Traditions of Plant Use and Cultivation on the Northwest Coast of North America” by Nancy Turner “The Burning Times” by Jeanne Kalogridis Southwest Colorado Wildflowers entry on Triteleia grandiflora (Wild Hyacinth, Large-flowered Onion), where the botanists mention the likelihood that the Utes brought it through trade from the Pacific Northwest and planted it to eat, given it is a very disjunct species from where it is normally found “The Ecology of Invasions by Animals and Plants” by Charles Elton “Charles S. Elton and the Dissociation of Invasion Ecology from the Rest of Ecology” by Mark Davis “Don't Judge Species on Their Origins” by Mark Davis and Matthew K. Chew “1491": New Revelations of the Americas before Columbus” by Charles Mann ECOLOGISTS, ENVIRONMENTALISTS, EXPERTS, AND THE INVASION OF THE ‘SECOND GREATEST THREAT' by Matthew K. Chew “The rise and fall of biotic nativeness: a historical perspective” by Matthew K. Chew “Invasions: the trail behind, the path ahead, and a test of a disturbing idea” by Angela Moles "Is rapid evolution common in introduced plant species?” by Angela Moles Torreya Guardians website: “Assisted Migration (Assisted Colonization, Managed Relocation, Translocation) and Rewilding of Plants and Animals in an Era of Rapid Climate Change” “Quantifying Threats to Imperiled Species in the United States: Assessing the relative importance of habitat destruction, alien species, pollution, overexploitation, and disease” by David Wilcove (this article is routinely cited as the reference for invasive species being the second greatest threat to biodiversity when it doesn't even say that, alongside Edward O. Wilson's 1992 book, “The Diversity of Life”) “Invasion Biology : Critique of a Pseudoscience” by David Theodoropoulos “Environmental determinism”: This is a wikipedia article on the history of environmental determinism in the contest of western colonialism and how this philosophy was used to justify abuses to human rights. “How conservation became colonialism” BY ALEXANDER ZAITCHIK “Forgotten Fires : Native Americans and the Transient Wilderness” by Omer C. Stewart   Call the podcast and leave us a message (you give us permission to potentially air it on the podcast): 1-434-233-0097   Support the podcast on Patreon to contribute monthly to our grassroots self-funding of this project  For one time donations to support this work: Paypal : paypal.me/petitfawn VENMO: @kelly-moody-6 Cashapp: cash.app/$groundshotsproject     Our website with an archive of podcast episodes, educational resources, past travelogues and more: http://www.ofsedgeandsalt.com  Our Instagram pages: @goldenberries / @groundshotspodcast Join the Ground Shots Podcast Facebook Group to discuss the episodes Subscribe to our newsletter for updates on the Ground Shots Project Theme music: 'Sweat and Splinters' by Mother Marrow Interstitial Music: “Big Ivy” by the Resonant Rouges Hosted by: Kelly Moody Produced by: Kelly Moody and Gabe Crawford

Resistance Recovery Founder Piers Kaniuka and healer and author Are Thoresen discuss Illness, Translocation, and the Christ. Recorded on December 2, 2020.To learn more about Are's publications visit https://www.rudolfsteinerbookcentre.c....Resistance Recovery (RR) is reimagining addiction, recovery, and community in the 21st century. Piers Kaniuka, MTS, MS has worked with thousands of addicts and alcoholics in his 25+ years in the field. Discover RR's new paradigm of addiction recovery by visiting http://resistancerecovery.com.Visit the RR YouTube channel: https://www.youtube.com/c/RESISTANCERECOVERYSign-up for Long Threads and get Resistance Recovery news: https://mailchi.mp/ddc8023bec67/welcometoresistancerecoverySupport this podcast at — https://redcircle.com/resistance-recovery/donations

Bridgette and Madison were best friends. Then sisters-in-law. One conceived. The other didn't. Both were in for surprises. This is their story. -- For more about Sarah's Laughter, please visit our website at sarahs-laughter.com. Our podcast-only site is podcast.sarahs-laughter.com. You can follow us on social media linked here: Sarah's Laughter on Facebook & Instagram, and @sarahs_laughter & @jasonforbus on Twitter. Sarah's Laughter also holds the Baby Steps Fun Run, where we give away a $10,000 grant for expenses related to either adoption or fertility treatment. We also partner with local SART-listed fertility clinics to give away IVFs at the event. Check babystepsfunrun.com for details and schedule. *** Sarah's Laughter is a 501(c)(3) nonprofit public charity. If you'd like to help support what we do, including this podcast, please visit sarahs-laughter.com/give. Thank you. -- Want to share your infertility story on this podcast? Email us at podcast@sarahs-laughter.com