Podcasts about cancer cells

In this episode of the Epigenetics Podcast, we talked with Ani Deshpande from Sanford Burnham Prebys about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. Throughout our discussion, we delve into Dr. Despande's journey into the field of biology and science, tracing his evolution from a literature enthusiast in Mumbai to a dedicated cancer researcher. He reflects on his formative experiences during his PhD at Ludwig Maximilian University in Munich, where she developed murine models for refractory acute myeloid leukemia (AML). We examine these models' contributions to therapeutic discovery and understanding the intricate mechanisms underscoring AML's complexities. Transitioning to his postdoctoral work at Scott Armstrong's lab in Boston, Dr. Despande shares his insights on the importance of epigenetic regulators, such as DOT1L, in leukemias, and how they can serve as strategic therapeutic targets. His ambitious pursuit of translational research is further highlighted through his efforts in developing a conditional knockout mouse model and his collaborative work utilizing CRISPR technology to refine our understanding of epigenetic regulation in cancer pathogenesis. Moreover, we engage in a conversation about the challenges and opportunities that arise when establishing his lab at Sanford Burnham Prebys. Dr. Despande candidly discusses the delicate balance between pursuing topics of genuine interest versus adhering to grant fundability, underlining the tension researchers face in the current scientific landscape. His emphasis on the critical need for innovation within lab settings serves as a motivational call for emerging scientists to venture beyond the established templates that often inhibit groundbreaking discoveries. We conclude our dialogue with an exploration of his recent projects, which involve targeting specific epigenetic modifiers and how his lab's findings can contribute to greater understanding and potential treatments for not only AML but also other pediatric cancers driven by gene fusions. Dr. Despande's insights into the integration of modern technologies, such as CRISPR libraries, exemplify his commitment to pushing the boundaries of cancer research. In addition to discussing his scientific contributions, we touch upon Dr. Despande's foray into podcasting (The Discovery Dialogues), shedding light on his motivation to bridge the communication gap between scientists and the broader public. He articulates his desire to demystify scientific discoveries and promote awareness about the intricate journey of research that lays the groundwork for medical advancements. This multidimensional discussion not only highlights his scientific achievements but also emphasizes the importance of effective science communication in fostering public understanding and appreciation of research.   References Deshpande AJ, Cusan M, Rawat VP, Reuter H, Krause A, Pott C, Quintanilla-Martinez L, Kakadia P, Kuchenbauer F, Ahmed F, Delabesse E, Hahn M, Lichter P, Kneba M, Hiddemann W, Macintyre E, Mecucci C, Ludwig WD, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006 Nov;10(5):363-74. doi: 10.1016/j.ccr.2006.08.023. PMID: 17097559. Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20. PMID: 25464900; PMCID: PMC4291116. Sinha S, Barbosa K, Cheng K, Leiserson MDM, Jain P, Deshpande A, Wilson DM 3rd, Ryan BM, Luo J, Ronai ZA, Lee JS, Deshpande AJ, Ruppin E. A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing. Nat Commun. 2021 Nov 11;12(1):6512. doi: 10.1038/s41467-021-26788-6. Erratum in: Nat Commun. 2022 May 16;13(1):2828. doi: 10.1038/s41467-022-30475-5. PMID: 34764240; PMCID: PMC8586238.   Related Episodes Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Is your daily diet secretly fuelling chronic disease? Dr. William Li reveals the shocking truth about what you're really eating. Dr. William Li is a world-renowned medical scientist specialising in chronic disease and blood vessel growth. He is Founder & President of the Angiogenesis Foundation, and his groundbreaking research has led to 44 medical treatments that target over 70 diseases. He is also the bestselling author of ‘Eat To Beat Your Diet'. He explains:  The number one common food that feeds cancer cells The surprising link between salt and accelerated aging How poor sleep is connected to belly fat The hidden health risks of microplastics in your diet How sugar quietly fuels chronic diseases 00:00 Intro   02:28 What Will People Out of This Conversation?   03:14 What Key Diseases Correlate to Diet?   04:35 Where Is Our Society at with Health and Food?   08:06 How Cancer Works in Our Body   14:50 How to Lower Your Risk of Cancer   16:09 Foods That Fuel Cancer   17:56 Debunking “Superfoods”   18:39 Risks of Electrolytes   19:46 Lowering the Body's Defenses: Risk of Consuming Added Sugars   21:26 Alcohol   22:08 Risks of Drinking Alcohol   22:43 How Does Stress Impact Immunity?   24:50 The Relationship Between Stress, Sleep, and Sickness   26:30 Why Lack of Sleep Contributes to Stress: The Glymphatic System   28:00 Deep Sleep Clears Your Mind and Burns Fat!   30:01 Why Are Cancer Cases in Young People Increasing?   32:54 Microplastics in Our Bodies   37:15 How Can I Lower My Exposure to Microplastics?   37:53 Benefits of Green Tea—but the Danger of Teabags!   40:17 Which Tea Has the Best Health Benefits?   41:32 Is Matcha Good for Me?   42:32 The Link Between Cured Meats and Cancer   46:10 My Personal Story with Cancer   58:50 Groundbreaking New Studies with AI   1:02:38 Successful Cancer Treatment Linked to Specific Gut Bacteria   1:09:01 What's the Best Food Diet?   1:13:04 Why Is Japan Considered One of the Healthiest Countries?   1:16:29 The Different Body Fat Types and How They Affect You   1:22:23 Visceral Fat: Dangerous for Cancer   1:33:43 The Link Between Fat and Coffee   1:40:55 Is Fasting Good for Fat Loss?   1:43:08 Brain Diseases   1:46:26 Food Is Medicine   1:52:39 Should We Use Food Supplements?   1:54:15 The Superfoods Helping Our Body  

On today's podcast, Stephanie and Tara talk about Biden's prostate cancer announcement, Trump's visit to Qatar and the UAE, Newsom's new plan for California's budget, Korean research showing cancer cells can be reverted back to normal, China's alleged ability to possibly control the U.S. solar power grid with a kill switch, and CERN has figured out how to turn lead into gold, which makes us question what else can they do? Become a beta tester for our new Unapologetically Outspoken GPT! Use the link here or head over to our website: https://www.thelawofattractiontribe.com/a/2148108179/MpCJCAPZ Want to join the conversation? Connect with Tara and Stephanie on TikTok, X, Rumble, YouTube, Truth Social, Facebook, and IG.https://msha.ke/unapologeticallyoutspoken/ Sign up to get on the waitlist for Stephanie's next Quantum Catalyst program here: https://www.thelawofattractiontribe.com/a/2148109722/MpCJCAPZ  

Send us a text

Prof. Thomas Seyfried is a professor of biology at Boston College and a leading researcher in cancer metabolism. He is best known for his book Cancer as a Metabolic Disease, where he argues that cancer is primarily caused by mitochondrial dysfunction rather than genetic mutations. Seyfried holds a Ph.D. in Genetics and Biochemistry and completed postdoctoral training in neurology at Yale University. His research focuses on metabolic therapies, including ketogenic diets, as potential treatments for cancer and neurological disorders. He has published over 150 scientific papers and is a prominent advocate for rethinking conventional cancer treatment approaches.In our conversation we discuss:(00:00) – Why cancer rates are doubling(06:54) – The real root cause of cancer and evolving treatments(13:07) – Why we believed cancer was mostly genetic(20:52) – The role of mitochondria in preventing cancer(25:54) – Did our ancestors get cancer? Lifespan vs. risk(28:46) – Lessons from the Inuit diet(31:42) – What's the optimal diet for cancer prevention?(42:05) – Understanding and measuring your GKI(46:12) – Intermittent fasting vs. prolonged fasting(55:32) – Cancer treatments and key supplements to know(58:26) – The role of NAD precursors in recoveryLearn more about Prof. SeyfriedUniversity profile - https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.htmlBook - https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention-ebook/dp/B00852YXZS?ref_=ast_author_mpbWatch full episodes on: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@seankim⁠⁠⁠⁠⁠⁠⁠⁠Connect on IG: ⁠⁠⁠⁠⁠⁠⁠https://instagram.com/heyseankim

Can we detect cancer so early such that we find the very first cell of cancer? Not just stage 1 cancer, but the first cell of cancer.In this episode, Dr. Michael Levin and I speak with Dr. Azra Raza. She is an oncologist pioneering early detection of cancer using electric signals. So far, our best solution to curing cancer has been to detect it early, and she wants to take this further, by nipping cancer at the very first cell.Her story with cancer is also deeply personal as she lost her husband to the disease. You can see in the episode how much she cares about solving cancer through early detection, and how aggrieved she is about the fact that not only have we made zero progress on cancer in the last 100 years, but doctors are also not focused on cancer prevention.Dr. Raza is also the author of the book The First Cell: And the Human Costs of Pursuing Cancer to the Last.Episode Show Notes: https://livelongerworld.com/p/arazaFind me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024TIMESTAMPS:0:00 New theory of cancer1:45 What causes cancer? 5:39 Hybrid cells in cancer 11:16 Why do cancer cells become immortal?14:14 Detecting the first cell of cancer17:09 Stress causes cancer cells to fuse21:40 Cancer drugs don't work universally25:54 Personalization of early cancer detection29:29 Detect cancer early using electrics35:46 Anguish of cancer patients39:06 Cancer progress hasn't moved in 100 years44:04 Doctors don't think of cancer prevention46:54 First Cell Therapeutics - Azra's company50:55 What is the first cell stage of cancer?54:55 Advice for cancer patientsAASTHA, LIVE LONGER WORLD:Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/LINKS:Michael Levin: https://twitter.com/drmichaellevinAzra Raza: https://azraraza.com/Azra Raza book The First Cell: https://amzn.to/4jGJzoJEpisode Show Notes: https://livelongerworld.com/p/arazaRELATED EPISODES:Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=gboyPAiLQrqg-y5YEKQiQQWhy Viruses Could Be the Cause of Chronic Disease | Dr. Paul Ewald: https://open.spotify.com/episode/2OdYInlzTy2zG3Mi6TgADY?si=Gnbg7efNSy21bS3q0c23jg

This episode is brought to you by ⁠⁠The Primal Tallow Balm.⁠⁠ PREVENT Cancer (Free Guide): http://www.theprimal.com/lab/eat-high-fat-the-fastest-way-to-kill-cancer-cellsProf Seyfried's Book 'Cancer As A Metabolic Disease': https://amzn.to/4c7PHUaProfessor Seyfried will discuss a new way to treat cancer using metabolic therapy, which is a combination of glucose and glutamine targeted therapies, along with a high-fat ketogenic diet. Professor Seyfried will explain why cancer is not a genetic disease and how the standard of care destroys all cells in the body, leaving patients sick and frail after therapy. Professor Seyfried will also share real success stories, including Pablo Kelly, who was diagnosed with a glioblastoma, given 9 months to live, and survived almost 8 years with metabolic therapy. This episode is important for understanding how to actively treat cancer with nutrition, metabolic therapy, and mitochondria science, and how to prevent cancer through lifestyle changes. Free Carnivore Calculator ⁠https://carnivore-diet.netlify.app/⁠Free Meal Planner https://carnivore-guide.vercel.app/

In this episode, Sarah Hall and Beth Wilmes continue the discussion of topics around reducing recurrence/disease progression by introduce the topic of CTDNA testing, also known as liquid biopsy. They explain how this test measures small fragments of cancer DNA in the blood and its potential benefits and limitations. The conversation includes insights from Dr. Cynthia Ax, an integrative breast surgical oncologist, who shares her perspectives on why doctors and patients opt for CTDNA testing, the emotional impacts of receiving test results, and the importance of a holistic approach to cancer care. The episode also touches on issues like the challenge of making lifestyle changes post-diagnosis, the collaborative potential between medical practitioners, and the critical role of mental health in the healing process. Dr. Cythia Aks: https://www.linkedin.com/in/cynthia-aks-865bb423/ Guest Profile: https://www.bestieswithbreastiespodcast.com/guests/cynthia-aks/ 00:00 Welcome to Besties with Breasty 00:58 Introduction to CT DNA Testing 02:38 Guest Introduction: Dr. Cynthia Ax 02:56 Sponsor Message: Faith Through Fire Survivorship Bootcamp 04:11 In-Depth Discussion with Dr. Ax 10:04 Challenges in Patient Lifestyle Changes 14:43 The Role of Primary Care in Survivorship 20:36 Boobs in the News: Peeled Bananas Mystery 21:11 The Mysterious Banana Plates 21:54 Community Reactions and Theories 23:31 Personal Anecdotes and Banana Dislike 25:06 Cancer Cells and Immune System 25:56 Empowering Patients with Knowledge 27:35 The Importance of Mental Health 32:05 Final Thoughts and Sponsor Message

BUFFALO, NY - April 2, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on March 21, 2025, titled “NSD2-epigenomic reprogramming and maintenance of plasma cell phenotype in t(4;14) myeloma." Researchers Andrea Gunnell, Scott T. Kimber, Richard Houlston, and Martin Kaiser from The Institute of Cancer Research, London, studied how a gene called NSD2 affects the behavior of multiple myeloma (MM) cells. Their findings reveal that NSD2 plays a key role in helping cancer cells retain their identity as plasma cells—white blood cells that normally help the immune system fight infections. This discovery could shape future treatment strategies for patients with a high-risk form of MM known as t(4;14) myeloma. Multiple myeloma is a type of blood cancer that begins in plasma cells found in the bone marrow. About 20% of patients have a genetic change called t(4;14), which makes the NSD2 gene highly active. The research team compared two types of myeloma cells: one with high NSD2 activity and one where NSD2 was turned off. They found that when NSD2 is active, it changes how DNA is folded and how genes are switched on or off, especially genes that help the cells act like plasma cells. When NSD2 was turned off, important markers like CD38 were reduced, and other genes normally silent in plasma cells were activated. The study indicated that NSD2 does not directly affect the main genes responsible for plasma cell creation. Instead, it influences many other genes that help maintain the cancer cell's identity, which contributes to cancer growth and survival. The researchers also observed physical changes in the cancer cells. Cells with active NSD2 looked and behaved more like typical plasma cells, while cells without NSD2 appeared more immature and lost important surface markers. These changes were linked to differences in how the DNA was organized inside the cells. These findings are especially important as new drugs are being developed to block NSD2. The study suggests that turning off NSD2 could change how MM cells respond to existing treatments. For example, if NSD2 is blocked and CD38 levels drop, the change might affect therapies that target CD38. However, the rise of other immune-related genes might make certain immunotherapies more effective. “Identifying the biological consequences of NSD2 over-expression in MM is not only relevant to informing new therapeutic interventions through indirect targeting of downstream effectors, but also to anticipate possible consequences of targeting NSD2 directly.” In summary, this study shows how NSD2 helps myeloma cells keep their cancerous identity by reorganizing the DNA and influencing gene activity. Understanding this role could help researchers design better treatment approaches and possibly overcome resistance to current therapies in t(4;14) myeloma. DOI - https://doi.org/10.18632/oncotarget.28706 Correspondence to - Andrea Gunnell - andrea.gunnell@icr.ac.uk Video short - https://www.youtube.com/watch?v=hibkjUpRq7I Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Le immunoterapie, pur avendo rivoluzionato il trattamento di molti tumori solidi, non risultano efficaci allo stesso modo in tutti i pazienti. In particolare, numerosi studi evidenziano una differente risposta terapeutica nei due sessi. Questo è quanto sottolinea una review appena pubblicata su Cancer Cell dal dott. Fabio Conforti, oncologo medico di Humanitas Gavazzeni e ricercatore di Humanitas University e il prof. Alberto Mantovani, Presidente di Fondazione Humanitas per la Ricerca e professore emerito dell’Ateneo. A Obiettivo Salute il commento del dottor Conforti.

Dr. Elizabeth Comen, MD, is a distinguished board-certified oncologist,researcher and author. She is an award-winning researcher and has beenpublished in prestigious scientific journals, including Nature, Cancer Cell and The Journal of Clinical Oncology. Her book “All In Her Head” empowers women to take charge of their health and to learn about the misconceptions of women's health. Her work has been featured on The Today Show, Good Morning America and Oprah. She joins us on The Vault to discuss ways that we can prevent cancer, how to address anxiety around cancer and how to advocate for your health as a woman in today's healthcare system. She addresses myths around hormone replacement therapy and cancer. We also discuss how to live a more purpose driven life as a physician and healthcare professional. What are the myths around HRT and cancer? How can I advocate for better healthcare as a woman in today's healthcare system? Ways to address cancer anxiety? How to prevent cancer and poor health outcomes? How to support loved ones who have been diagnosed with cancer? What are ways to encourage loved ones to get cancer screenings? How to Cope with High Functioning Depression.Follow Dr. Elizabeth Comen: Dr. Elizabeth Comen Instagram https://www.instagram.com/drelizabethcomen/ Dr. Elizabeth Comen Book https://www.amazon.com/All-Her-Head-Medicine-Matters/dp/0063293013 Dr. Elizabeth Comen Website https://www.drelizabethcomen.com/Follow Dr. Judith:Instagram: https://instagram.com/drjudithjoseph TikTok: https://www.tiktok.com/@drjudithjoseph Facebook: https://www.facebook.com/drjudithjoseph Website: https://www.drjudithjoseph.com/Sign up for my newsletter here: https://www.drjudithjoseph.com/newsletter-sign-upDisclaimer: You may want to consider your individual mental health needs with a licensed medical professional. This page is not medical advice.

Scientists at Oregon State University and Oregon Health and Science University have teamed up to find new ways to treat endometriosis, ovarian cancer and other health conditions using nanoparticles and magnetic fields. Joining us to tell us more about this fascinating research are OPB science reporter Jes Burns, who is also the host and producer behind the “All Science. No Fiction.” video series, and OPB cinematographer and editor Brooke Herbert. This episode was recorded with a live audience at the Tomorrow Theater in Portland.   You can see the video about the medical applications of magnetic nanoparticles here.   For more Evergreen episodes and to share your voice with us, visit our showpage. Follow OPB on Instagram, host Jenn Chávez and Oregon Field Guide. You can sign up for OPB’s newsletters to get what you need in your inbox regularly.   Don’t forget to check out our many podcasts, which can be found on any of your favorite podcast apps: Hush Timber Wars Season 2: Salmon Wars Politics Now Think Out Loud And many more! Check out our full show list here.

On today's episode, our solar system is being invaded by particles from another star system and combating cancer by switching tumor cells back into healthy cells. Plus, on This Day in History, the first electric burglar alarm is installed. Scientists Think Visitors From Another Star System May Have Infiltrated Our Galactic Neighborhood | Popular Mechanics 'Cosmic Highway' Discovered: How Alpha Centauri's Debris May Link Our Solar System to Faraway Stars | Daily Galaxy [2502.03224] A Case Study of Interstellar Material Delivery: α Centauri Fighting Cancer Without Fighting: Scientists Switch Tumor Cells Back to Healthy Ones at 'Critical' Moment | Good News Network ​Almanac: The burglar alarm - CBS News Our Father's Beginning | Wayback Machine Who Was Augustus Russell Pope | Wayback Machine Contact the show - coolstuffcommute@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 2608: In this episode, Vinnie Tortorich and Chris Shaffer discuss how ketones fight cancer cells, another claim made by a GLP-1 med, and more. https://vinnietortorich.com/2025/02/ketones-fight-cancer-cells-episode-2608 PLEASE SUPPORT OUR SPONSORS YOU CAN WATCH ALL THE PODCAST EPISODES ON YOUTUBE - Ketones Fight Cancer Cells Chris Stapleton and trends in country music. (2:00) UPenn study references that the Keto diet can fight off cancer in early stages, and if undergoing chemo, can help with recovery. (20:00) Dr. Thomas Seyfried has been on the show discussing this. (22:00) Vinnie is an N=1 experiment of this. He believes that keeping himself in ketosis helped to stave off a remission in his cancer. He was told his cancer would return in 5 years; however, it didn't return for almost 17 years. His experience this time around was a bit different, but still better than his first battle with cancer. (24:00) He shares all the random advice he was given as “remedies” for his cancer while living in Hollywood. Hims/Hers and GLP-1s. The FDA should look at how this product is advertised without disclaimers. (38:00) Chris reviews a study suggesting that Wegovy lessens alcohol use. (42:00) They discuss why they have their doubts about this. It appears to be just another angle to try to advocate the use of the drug as alcohol use disorders are very complicated. Pure Vitamin Club and NSNG Foods are up and running and back to full speed! More News If you are interested in the NSNG® VIP group, closed for registration, but you can get on the wait list - Don't forget to check out Serena Scott Thomas on Days Of Our Lives on the Peacock channel.  “Dirty Keto” is available on Amazon! You can purchase or rent it . Make sure you watch, rate, and review it! Eat Happy Italian, Anna's next cookbook is available!  You can go to You can order it from . Anna's recipes are in her cookbooks, website, and Substack–they will spice up your day! Don't forget you can invest in Anna's Eat Happy Kitchen through StartEngine.  Details are at Eat Happy Kitchen. There's a new NSNG® Foods promo code you can use! The promo code ONLY works on the NSNG® Foods website, NOT on Amazon. https://nsngfoods.com/ [the_ad id="20253"] PURCHASE  DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere: Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere: REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere:

Dr. Michael Klaper presents the scientific evidence behind disease reversal through plant-based nutrition. Discover how dietary changes can lead to significant health improvements and disease prevention. #PlantBasedNutrition #DiseaseReversal #HealthScience

Romain Banchereau joins the show to discuss and debate this Cancer Cell paper on molecular subtypes in urothelial cancer and implications for checkpoint blockade.

Professor Thomas Seyfried joins the conversation to challenge the conventional view of cancer as a genetic disease, presenting it instead as a metabolic disorder influenced by lifestyle factors. With over 30 years of research, Seyfried argues that current cancer treatments may exacerbate the disease. He discusses the role of glucose and glutamine in cancer metabolism and emphasizes the potential of metabolic therapy, including ketogenic diets, for prevention and management. Explore the compelling intersection of biochemistry, lifestyle, and cancer with Seyfried's groundbreaking insights.Sponsors:ZocDoc: https://www.zocdoc.com/neuroHone Health Hormone Testing: https://honehealth.com/Momentous - Use code NEURO to get 20% off your order - https://www.livemomentous.com/neuro Timestamp 0:00 Challenging Cancer's Genetic Theory with Metabolic Insights4:54 Cancer as a Metabolic Disorder Not a Genetic Disease13:05 Challenging the Genetic Theory of Cancer Amidst Confirmation Bias15:27 Booking Doctor Appointments Easily with ZocDoc16:27 Mitochondria's Role in Cancer Cell Proliferation and Fermentation21:08 Mitochondrial Dysfunction and Its Role in Cancer Development31:23 Cancer Cells' Fermentation and Mitochondrial Dysfunction37:33 Metabolic Therapy as a Non-Toxic Cancer Treatment Alternative46:39 Exploring Diets and Metabolic Pressure on Cancer Cells49:36 Exercise and Diet in Cancer Treatment Targeting Glutamine50:50 Ketogenic Lifestyle's Impact on Cancer and Chronic Diseases52:40 Targeting Glucose and Glutamine to Combat Pancreatic Cancer54:36 Impact of Modern Lifestyle on Health and Chronic Diseases58:26 Metabolic Therapy as a Disruptive Cancer Prevention and TreatmentThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

This week Zorba and Karl discuss standing work desks, and they examine new research that found certain foods disrupt your body's fight against cancer cells. Plus, they share a delicious recipe for Marinated winter squash with sage.

This week Zorba and Karl discuss standing work desks, and they examine new research that found certain foods disrupt your body's fight against cancer cells. Plus, they share a delicious recipe for Marinated winter squash with sage.

In this episode we discuss an herbal tea that has the ability to potentially inhibit the growth of cancer cells.Our website: https://acupunctureismylife.com/Follow our social media for more information on acupuncture:Instagram: https://www.instagram.com/acupunctureismylife/Facebook: https://www.facebook.com/acupunctureismylifeTikTok: https://www.tiktok.com/@acupunctureismylife?lang=e

In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman discuss the complexities of cancer with Dr. Joe Zundell, a cancer biologist. They explore the definition of cancer, its prevalence, and the hallmarks that characterize cancer cells. The conversation delves into the mechanisms of cancer growth, including sustaining proliferative signaling, evading growth suppression through the P53 gene, and the process of apoptosis. The discussion aims to make these complex topics accessible to a broader audience while highlighting the importance of understanding cancer biology. In this conversation, Dr. Joe Zundell discusses the complexities of cancer biology, focusing on key hallmarks such as immune response, replicative immortality, angiogenesis, and metastasis. He emphasizes the importance of early detection and the challenges of targeting cancer cells without affecting healthy cells. The discussion highlights the need for careful consideration of information regarding cancer treatment and the significance of working with healthcare professionals. All our sources from this episode are available at: https://www.unbiasedscipod.com/episodes/ (00:00) Introduction  (05:28) Understanding Cancer: Definitions and Statistics (10:15) The Hallmarks of Cancer: An Overview (15:14) Sustaining Proliferative Signaling in Cancer (20:07) Evading Growth Suppression: The Role of P53 (25:17) Apoptosis: The Controlled Cell Death Mechanism (30:21) Understanding Cancer: Immune Response and Cell Death (33:31) Replicative Immortality: The Hayflick Limit (38:27) Angiogenesis: Blood Vessel Formation in Tumors (46:32) Invasion and Metastasis: The Spread of Cancer (54:22) Final Thoughts: The Complexity of Cancer Treatment and Early Detection Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Caterpillar Virus May Slow The Growth Of Cancer Cells bonus 58 Fri, 08 Nov 2024 02:38:27 +0000 1cNhAGvyJnAhlcGnOXcvjd2F6WHoFvLM news,pop culture,comedy,society & culture The Mens Room Daily Podcast news,pop culture,comedy,society & culture The Caterpillar Virus May Slow The Growth Of Cancer Cells From sinners to saints, kings to commoners, rock stars and regular folks. Everyone is here and they're sharing their stories. Sit down and grab a beer with the men of The Mens Room. 2024 © 2021 Audacy, Inc. Society & Culture False https://player.amperwavepodcasting.

BUFFALO, NY- October 23, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on October 11, 2024, entitled, “Gene regulatory network and signalling pathway rewiring: How blood cancer cells shift their shapes to evade drug treatment.” As highlighted in the paper, Acute Myeloid Leukemia (AML) is a complex and diverse disease caused by multiple mutations in genes that regulate transcription and growth. These mutations lead to extensive rewiring of the gene regulatory network (GRN), which alters the identity of hematopoietic stem and progenitor cells, ultimately blocking normal myeloid differentiation. A key feature of AML is the presence of mutations in growth factor receptor and signaling genes, such as FLT3, KIT, and RAS. Notably, FLT3 is one of the most commonly mutated genes in AML, with around 25% of cases showing an internal tandem duplication (ITD) that causes the receptor to remain constantly active. In their paper, researchers Constanze Bonifer and Peter N. Cockerill from the Institute of Cancer and Genomic Sciences at the University of Birmingham, UK, and the Murdoch Children's Research Institute, Royal Children's Hospital in Melbourne, Australia, discuss recent publications from their group addressing this issue through a multi-omics study. The authors investigated how gene regulatory networks (GRNs) in FLT3-ITD patients were rewired compared to normal cells and in response to FLT3 inhibitor treatment. Several key findings stood out, including: 1) Mapping of open chromatin regions revealed that patients initially responsive to FLT3 inhibition showed significant rewiring of their GRNs, forming new connections between transcription factors (TFs) and target genes, while non-responsive patients did not; 2) Chromatin immunoprecipitation (ChIP) experiments showed that drug treatment led to the loss of binding of RUNX1, the master regulator of hematopoiesis, and the MAP-Kinase (MAPK)-inducible TF AP-1; 3) Disruption of AP-1 binding via a dominant-negative version of the TF (dnFOS) also abolished RUNX1 binding at hundreds of sites, indicating that RUNX1 binding is AP-1 dependent; and 4) Inhibition of both AP-1 and RUNX1 led to a pronounced cell cycle block. “In summary, drugs that target individual signalling pathways in AML often fail to stop proliferation malignant growth, due to the wide variety, redundancy and cross talk between multiple pathways regulating and differentiation.” DOI - https://doi.org/10.18632/oncotarget.28662 Correspondence to - Constanze Bonifer - constanze.bonifer@mcri.edu.au Video short - https://www.youtube.com/watch?v=5c_uT6aE36A Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28662 Subscribe for free publication alerts from Oncotarget: https://www.oncotarget.com/subscribe/ Keywords - cancer, acute myeloid leukemia, gene regulatory networks, aberrant growth factor signaling, transcription, RUNX1/AP-1 axis About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

How do Vitamin D and genomic ancestry impact cancer cells? Dr. Moray J. Campbell, a research scientist at Cedars-Sinai Cancer, joins the podcast to explain… Dr. Campbell is a cancer biologist who studies the genomic and epigenomic drivers of hormone-dependent cancers. By utilizing high-dimensional data approaches and bioinformatic analyses, Dr. Campbell is on a mission to uncover the scientific mysteries of cancer. Jump into the conversation now to find out: How Vitamin D and genomic ancestry influences prostate cancer.  How prostate cancer cells bind to patients depending on their genetic makeup. How gene expression in prostate cancer works. Where people get most of their Vitamin D from.  Want to learn more about Dr. Campbell and his research? Click here now! Episode also available on Apple Podcasts: http://apple.co/30PvU9C

"Deuterium is like sugar in the gas tank to the mitochondria." In this conversation, Dr. Stephanie Seneff discusses the health implications of glyphosate and deuterium, emphasizing their roles in obesity, cancer, and mitochondrial dysfunction. She highlights the importance of gut health and the potential benefits of deuterium depletion. The discussion also covers dietary choices, the impact of glyphosate on gut microbes, and practical steps for reducing deuterium levels in the body. Takeaways ✅ Glyphosate is a significant health threat linked to various diseases. ✅ Deuterium, a heavy hydrogen, can disrupt cellular functions. ✅ The connection between glyphosate and deuterium is crucial for understanding health issues. ✅ Deuterium depletion may improve outcomes for cancer patients. ✅ Gut health is essential for managing deuterium levels. ✅ Organic diets can help reduce glyphosate exposure. ✅ Cholesterol is a low deuterium nutrient that supports health. ✅ Hydrogen water may provide low deuterium benefits. ✅ Cancer cells may play a role in supplying deuterium-depleted nutrients. Chapters 00:00 Introduction and the Dangers of Glyphosate 03:13 Introduction to Deuterium and its Connection to Glyphosate 07:58 Research on Deuterium Depletion and Cancer 12:22 The Role of Gut Microbes in Deuterium Management 18:34 The Relationship Between Deuterium and Metabolic Health 24:56 The Impact of Diet on Deuterium Levels 28:40 Glyphosate and Connective Tissue Breakdown 31:17 Lowering Deuterium Levels with Water and Diet 42:08 The Benefits of Spirulina and Chlorella 44:27 The Potential of Hydrogen Water 49:28 The Purpose of Cancer Cells

Try a FREE Fit Vegan Fat Burning Meal Plan - https://www.fitvegancoaching.com/fitvegan-mealplan-builder Book Your FREE Consultation Call Here: http://book.fitvegancoaching.com/podcastWelcome to the Fit Vegan Podcast! In this very special episode, Nathan Crane shares his journey from sickness and addiction to finding true fulfillment and purpose in serving others. He emphasizes that true happiness and fulfillment come from service to others. He shares his experiences with volunteering and donating to help others and how it has brought him joy and abundance, and much more. In This Episode, We Cover: [00:00-12:21] Intro - This is Nathan Crane! The Illusion of Material Happiness and The Shift in Perspective[12:22-21:23] From Success to Spiritual Path, Finding Happiness with Nothing.[21:24-37:24] Balancing the Material and Spiritual Worlds, Taking Action and Making a Difference[37:25-56:31] Introduction to Plant-Based Eating and Embracing Compassion and Sustainability.[56:32-1:16:24] Plant Powered Athlete: High-Quality Supplements, Thinking of Yourself as an Athlete and The Role of Stretching and Mobility[1:16:25-1:26:30] Stopping the Production of Cancer Cells, Deficiencies and Toxicities in the Body & Oxygen and Alkalinity for Cancer Prevention.[1:26:31-1:39:08] Making Informed Treatment Decisions, Prioritizing Self-Care and Health - Chronic Inflammation and Cancer [1:39:09-1:52:58] Focusing on Joy and Positivity, Nathan's Personal advice! - Closing Segment.Key Quotes“Health is instrumental in living a meaningful life” -Nathan Crane.“It's not just about nutrition, it[‘s not just about sleep, it's about the whole view in multiple areas that you need to deal with.” - Maxime.My name is Maxime Sigouin. I am the founder of Fit Vegan Coaching and Empire Builders Agency. I have a passion for serving and helping people live to their fullest potential.I've built and scaled one of the world's top whole food plant-based body recomposition program which you should check out and book your FREE introductory coaching call : http://book.fitvegancoaching.com/podcastIf you are an online coach looking to scale pass 100K+/year you can apply here for mentorship: www.empirebuilder.agencyYou can find me on social media:- Follow me on Instagram: https://www.instagram.com/maximes_official/- Join our FREE Fit Vegan Facebook Community: https://www.facebook.com/groups/thefitvegancommunity- Get your FREE Fit Vegan Meal Plan Blueprint to help you create your own Fit Vegan meal plan https://www.fitvegan.ca/fitvegan-mealplan-builder- Youtube Channelhttps://www.youtube.com/channel/UCBTxPyHiMLIc14IGWmVrFow

Zach Bush MD is a physician specializing in internal medicine, endocrinology and hospice care. He is an internationally recognized educator and thought leader on the microbiome as it relates to health, disease, and food systems. Dr Zach founded *Seraphic Group and the nonprofit Farmer's Footprint to develop root-cause solutions for human and ecological health. His passion for education reaches across many disciplines, including topics such as the role of soil and water ecosystems in human genomics, immunity, and gut/brain health. His education has highlighted the need for a radical departure from chemical farming and pharmacy, and his ongoing efforts are providing a path for consumers, farmers, and mega-industries to work together for a healthy future for people and planet. ___________________ PODCAST CHAPTERS 00:00 - Zach Bush MD Intro 01:10 - Opening Prayer: Nature's Creative Process 03:10 - Surrendering the Five Senses 04:45 - Expanding Intuition and Inner Knowing 06:20 - Letting Go of Fear and Embracing Change 08:35 - Erasing Generational Trauma and Creating a New Reality 10:55 - Zach's Recent Personal Excitement 12:35 - Prophecy of 2027 & Human Transformation 16:40 - The Holographic Nature of Reality 18:40 - Human Experience Beyond the Physical Body 23:15 - The Journey of Fear, Guilt, and Shame 24:50 - Unity and Right Relationship with Nature 27:00 - Historical Amnesia and Indigenous Wisdom 30:20 - Near-Death Experiences and Eternal Identity 32:20 - Freedom and Rapid Acquisition of Knowingness 34:40 - The Role of Food and Water in Creativity 36:50 - Emilio's Intention of Freedom for 2024 42:55 - Technology's Impact on Imagination 45:30 - Importance of Face-to-Face Interaction 47:25 - Energy and Connection in Egypt 49:35 - King's Chamber Experience 53:15 - Connecting to the Stillness of the Universe 59:20 - Flow of Energy and Bank Accounts 01:00:14 - Leveraging Relationships for Growth 01:04:12 - Insights from Deathbeds 01:06:05 - Cubic Opportunity and Form Shift 01:07:20 - Structure of DNA and Water 01:09:09 - Liquid Crystals and Light Energy 01:11:00 - Differences in Crystalline Structures 01:12:59 - Evolution and Conformational Changes 01:15:05 - Seismic Leaps in Biological History 01:19:23 - Nature's Death and Rebirth Cycle 01:22:29 - Frequency of Love and Human Potential 01:23:30 - Four-Stranded DNA in Cancer Cells 01:25:55 - Changing Water Structure and Healing 01:30:07 - Spiritual Wisdom and Stillness 01:32:00 - Excitement About New Retreats 01:33:37 - Gratitude and Brotherhood ___________________ Guest: Zach Bush MD Website | https://zachbushmd.com/ YouTube |  @ZachBushMD  Knowledge Base | https://zachbushmd.com/knowledge-base/ Instagram | https://www.instagram.com/zachbushmd/ Resources: ✦ Journey to Ixtlan: The Lessons of Don Juan (By Carlos Castañeda) Host: Emilio Ortiz Instagram | https://www.instagram.com/iamemilioortiz/ Subscribe to YouTube Channel |  @EmilioOrtiz  Watch Emilio's latest series on 4biddenknowledge TV l https://bit.ly/AwakenThe6thSense Shop Our Clothing Collection l https://www.unlockedmovement.com/collections/justtapin ___________________ Special Offerings to Support the Show: ✦ Make a One-Time or Recurring Donation on PayPal

Show Notes 20 September 2024Story 1: World's Biggest Battery Will Provide 85 Megawatts to New England GridSource: Singularityhub.com Story by Edd GentLink: https://singularityhub.com/2024/08/23/worlds-biggest-battery-will-provide-85-megawatts-to-new-england-grid/See also: https://formenergy.com/massachusetts-new-england-states-selected-to-receive-389-million-in-federal-funding-for-transformational-transmission-and-energy-storage-infrastructure/Story 2: Origami-inspired 'transformer' robots could help build habitats in space - These configurable bots could launch flat and then be assembled in spaceSource: Space.com Story by Samantha MathewsonLink: https://www.space.com/origami-inspired-robot-space-habitatsSee also: https://news.ncsu.edu/2024/07/transformer-bot/See also: https://www.nature.com/articles/s41467-024-50497-5See video here: https://www.youtube.com/watch?v=rA6fGJC8TFQStory 3: New engineering approach could lead to widespread adoption of photonic chips in consumer electronicsSource: TechXplore.com Article by TMOSLink:  https://techxplore.com/news/2024-09-approach-widespread-photonic-chips-consumer.htmlSee also: https://www.nature.com/articles/s41377-024-01570-7Story 4: Scientists Destroy 99% of Cancer Cells in Lab with Vibrating MoleculesSource: ScienceAlert.com Story by David NieldLink: https://www.sciencealert.com/scientists-destroy-99-of-cancer-cells-in-lab-with-vibrating-moleculesSee also: https://news.rice.edu/news/2023/molecular-jackhammers-good-vibrations-eradicate-cancer-cellsFor more info, interviews, reviews, news, radio, podcasts, video, and more, check out ComputerAmerica.com!

Oren Gilad, President and CEO of Aprea Therapeutics, focused on the DNA damage response pathway, specifically targeting the ATR protein. ATR is a master regulator of DNA replication and is hyperactive in cancer cells, making it a potential Achilles heel for cancer therapy. By inhibiting ATR, cancer cells can be selectively targeted, while normal cells can tolerate lower levels of ATR activity. Synthetic lethality is applied when two genetic mutations are combined, leading to cell death, specifically in cancer cells. Aprea is conducting clinical trials for their targeted treatments, focusing on solid tumors with defined genetic mutations. Oren explains, "DDR, the DNA damage response pathway, is the broader terminology for the regulation of DNA synthesis. In order for cancer to grow, cells have to duplicate. In order for them to duplicate, they have to replicate their DNA. So what happens is that cancer cells get into this DNA replication phase very early and prematurely, causing a single-strand DNA to be exposed which then activates the ATR pathway, where in normal cells, this pathway is very tightly regulated. The normal cell is not going to enter this phase and start DNA replication before the environment is ready because it's a very fragile phase of the cell cycle." "Double-strand DNA is a very stable molecule. It is found in mummies, it survives heat, and it survives freezing. When a double-strand DNA molecule is opened, the exposed single-strand DNA can easily break. That's where ATR comes into play, it protects and responds to single-strand formation. A cancer cell is hyper-sensitive to ATR inhibition, which we identify as the Achilles heel of cancer. Our work showed that normal cells can live with a reduced level of the ATR activity, so it makes it a good target for cancer therapy." #ApreaTherapeutics #CancerTreatment #TargetedTherapy #Oncology #Cancer #SyntheticLethality #DNADamageResponsePathway aprea.com Download the transcript here

Oren Gilad, President and CEO of Aprea Therapeutics, focused on the DNA damage response pathway, specifically targeting the ATR protein. ATR is a master regulator of DNA replication and is hyperactive in cancer cells, making it a potential Achilles heel for cancer therapy. By inhibiting ATR, cancer cells can be selectively targeted, while normal cells can tolerate lower levels of ATR activity. Synthetic lethality is applied when two genetic mutations are combined, leading to cell death, specifically in cancer cells. Aprea is conducting clinical trials for their targeted treatments, focusing on solid tumors with defined genetic mutations. Oren explains, "DDR, the DNA damage response pathway, is the broader terminology for the regulation of DNA synthesis. In order for cancer to grow, cells have to duplicate. In order for them to duplicate, they have to replicate their DNA. So what happens is that cancer cells get into this DNA replication phase very early and prematurely, causing a single-strand DNA to be exposed which then activates the ATR pathway, where in normal cells, this pathway is very tightly regulated. The normal cell is not going to enter this phase and start DNA replication before the environment is ready because it's a very fragile phase of the cell cycle." "Double-strand DNA is a very stable molecule. It is found in mummies, it survives heat, and it survives freezing. When a double-strand DNA molecule is opened, the exposed single-strand DNA can easily break. That's where ATR comes into play, it protects and responds to single-strand formation. A cancer cell is hyper-sensitive to ATR inhibition, which we identify as the Achilles heel of cancer. Our work showed that normal cells can live with a reduced level of the ATR activity, so it makes it a good target for cancer therapy." #ApreaTherapeutics #CancerTreatment #TargetedTherapy #Oncology #Cancer #SyntheticLethality #DNADamageResponsePathway aprea.com Listen to the podcast here

This episode features Dr. David Harper, who will discuss the root cause of cancer and the nutrition protocols to starve cancer cells. Dr Harper will discuss the truth about cancer and why cancer is not a genetic disease. Dr. Harper will explain the gene mutations that occur from cancer cells and the science behind metabolic therapy to starve cancer cells, reduce tumor (carcinomas) size, and ultimately prevent cancer. Access the full show notes, including referenced articles, books, and additional resources: https://www.theprimal.com/lab/starve-cancer-cells-heal-the-body-with-nutrition Dr. Harper explains the three axes of what causes cancer, hyperinsulinemia, hyperglycemia, and chronic inflammation, and the mechanism by which all three lead to chronic disease, which includes cancer but also many other chronic health conditions like dementia, heart disease, stroke, and obesity. Dr Harper will share the science behind the Ketogenic diet as a nutritional protocol to starve cancer cells and the role of Beta-Hydroxybutyrate, MTOR, and AMPK in preventing cancer (via up-regulation and down-regulation of certain mechanisms). This episode is important for understanding how to actively treat cancer with nutrition, the science of metabolic therapy and mitochondria, and how to prevent cancer through lifestyle changes.

In this episode of the Epigenetics Podcast, we talked with Johnathan Whetstine from Fox Chase Cancer Center about his work on how histone demethylases affect gene expression and cancer cell stability. The Interview start by discussing a pivotal paper from Jonathan's lab in 2010, where they identified a role for the KDM4A histone demethylase in replication timing and cell cycle progression. They elaborate on the discoveries made regarding the link between histone marks, replication timing, and gene expression control. Jonathan explains the impact of microRNAs on regulating KDM4A and how protein turnover rates can influence cellular responses to treatments like mTOR inhibitors. Further, they explore the causal relationship between histone marks and replication timing, demonstrating how alterations in epigenetic regulation can affect genome stability. Jonathan shares insights from his latest research on H3K9 methylation balance at the MLL-KM2A locus, elucidating how these epigenetic modifications regulate amplifications and rearrangements in cancer cells. The episode concludes with a discussion on the establishment of the Cancer Epigenetics Institute at Fox Chase Cancer Center, aiming to bridge academia and industry to accelerate translational research in cancer epigenetics.   References Black, J. C., Allen, A., Van Rechem, C., Forbes, E., Longworth, M., Tschöp, K., Rinehart, C., Quiton, J., Walsh, R., Smallwood, A., Dyson, N. J., & Whetstine, J. R. (2010). Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. Molecular cell, 40(5), 736–748. https://doi.org/10.1016/j.molcel.2010.11.008 Mishra, S., Van Rechem, C., Pal, S., Clarke, T. L., Chakraborty, D., Mahan, S. D., Black, J. C., Murphy, S. E., Lawrence, M. S., Daniels, D. L., & Whetstine, J. R. (2018). Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell, 174(4), 803–817.e16. https://doi.org/10.1016/j.cell.2018.06.018 Van Rechem, C., Ji, F., Chakraborty, D., Black, J. C., Sadreyev, R. I., & Whetstine, J. R. (2021). Collective regulation of chromatin modifications predicts replication timing during cell cycle. Cell reports, 37(1), 109799. https://doi.org/10.1016/j.celrep.2021.109799 Gray, Z. H., Chakraborty, D., Duttweiler, R. R., Alekbaeva, G. D., Murphy, S. E., Chetal, K., Ji, F., Ferman, B. I., Honer, M. A., Wang, Z., Myers, C., Sun, R., Kaniskan, H. Ü., Toma, M. M., Bondarenko, E. A., Santoro, J. N., Miranda, C., Dillingham, M. E., Tang, R., Gozani, O., … Whetstine, J. R. (2023). Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement. Cell, 186(21), 4528–4545.e18. https://doi.org/10.1016/j.cell.2023.09.009   Related Episodes The Impact of Chromatin Modifiers on Disease Development and Progression (Capucine van Rechem)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Cancers pretend to be ‘super fit' to steal nutrients from healthy cells. Weight-loss jab approved for use in UK to prevent heart attacks and strokes. Video footage shows breaching whale capsize boat. Sharks found in waters off Brazil test positive for cocaine. Also in this episode:Data watchdog reprimands school over facial recognition for canteen paymentsCalls to rethink smartphone use for under 18s to improve mental healthElon Musk: Tesla will begin using humanoid robots next yearFollow us on X or on Threads. Hosted on Acast. See acast.com/privacy for more information.

The western American diet is under fire for the amount of sugar we consume on a daily basis. Overconsumption of sugar creates all sorts of health issues for us and it is a big topic of discussion for everyone these days, especially cancer patients.In this episode, Dr. Lucas Tims returns for a second time to talk about sugar and the role it plays in cancer. Can consuming sugar increase your risk for cancer?Are there certain types of cancers that are more sensitive to sugar intake?Does sugar affect cancer treatments?Are artificial sweeteners beneficial to someone on a cancer journey?Dr. Tims answers these questions and talks about how sugar consumption can lead to inflammation in the body. This inflammation can create an environment that is conducive to cancer growth.  He also discusses the importance of maintaining a healthy, balanced diet that is low in sugar and high in nutrients, sharing how he has helped his patients reduce their sugar consumption in their individual health journeys. You won't want to miss this enlightening episode!Connect with Dr. Tims: https://doctorlucas.orgSuggested Resource Links:LINK (PubMed Article): The Warburg Effect, Diet Based Strategies for Cancer PreventionWEBSITE:  Dr. Thomas Seyfried BLOG:  Educational ArticlesYour donations power our podcast's mission to support cancer patients with hope, insights, and resources. Every contribution fuels our ability to uplift and empower. Join us in making a lasting impact. Donate now!

Join Stephanie and Kenna for the last episode of the season as they discuss a new nano robot developed in Sweden that can kill cancer cells in mice. They also open a channel to the ISS and discuss how NASA is using laser relays to send photos and messages to astronauts. Lastly, they take a trip and talk about how a new study says that micro-doses of LSD can aid in healthy sleep. The Debrief Weekly Report will be back on August 20th, 2024 bringing all the latest and greatest science news from the pages of The Debrief. Every Tuesday, join hosts Stephanie Gerk, Kenna Hughes-Castleberry, and MJ Banias as they round up the latest science and tech stories from the pages of The Debrief. From far-future technology to space travel to strange physics that alters our perception of the universe, The Debrief Weekly Report is meant for the dreamers who love the science and technology of the future.   Read all the stories mentioned at The Debrief: www.thedebrief.org Follow the Debrief on X: https://twitter.com/Debriefmedia Follow MJ Banias on X: https://x.com/mjbanias Follow Stephanie Gerk on X: https://twitter.com/stephgerk Follow Kenna Hughes-Castleberry on X: https://twitter.com/kennaculture Have something to tell us? Email the show at weeklyreport@thedebrief.org

BUFFALO, NY- June 26, 2024 – A new research perspective was published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Starving cancer cells to enhance DNA damage and immunotherapy response.” Prostate cancer (PCa) poses significant challenges in treatment, particularly when it progresses to a metastatic, castrate-resistant state. Conventional therapies, including chemotherapy, radiotherapy, and hormonal treatments, often fail due to toxicities, off-target effects, and acquired resistance. In this new research perspective, researchers Aashirwad Shahi and Dawit Kidane from Howard University define an alternative therapeutic strategy focusing on the metabolic vulnerabilities of PCa cells, specifically their reliance on non-essential amino acids such as cysteine. “In this prospective, we will rise the driving questions and potential possibilities how amino acid depletion induced oxidative stress associated DNA damage exploited for DNA repair targeted and immune checkpoint blockade therapy [...].” Using an engineered enzyme cyst(e)inase to deplete the cysteine/cystine can induce oxidative stress and DNA damage in cancer cells. This depletion elevates reactive oxygen species (ROS) levels, disrupts glutathione synthesis, and enhances DNA damage, leading to cancer cell death. The combinatorial use of cyst(e)inase with agents targeting antioxidant defenses, such as thioredoxins, further amplifies ROS accumulation and cytotoxicity in PCa cells. “Overall, this perspective provides a compressive overview of the previous work on manipulating amino acid metabolism and redox balance modulate the efficacy of DNA repair-targeted and immune checkpoint blockade therapies in prostate cancer.” DOI - https://doi.org/10.18632/oncotarget.28595 Correspondence to - Dawit Kidane - dawit.kidane-mulat@howard.edu Video short - https://www.youtube.com/watch?v=Zrj24o_-b50 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28595 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, amino acid depletion, DNA damage, DNA repair, Immunotherapy, tumor immunity About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- June 5, 2024 – A new research paper was published in Oncotarget's Volume 15 on June 3, 2024, entitled, “Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy.” Histone deacetylase inhibitors (HDACi) can modulate the acetylation status of proteins, influencing the genomic instability exhibited by cancer cells. Poly (ADP ribose) polymerase (PARP) inhibitors (PARPi) have a direct effect on protein poly (ADP-ribosyl)ation, which is important for DNA repair. Decitabine is a nucleoside cytidine analogue, which when phosphorylated gets incorporated into the growing DNA strand, inhibiting methylation and inducing DNA damage by inactivating and trapping DNA methyltransferase on the DNA, thereby activating transcriptionally silenced DNA loci. In this new study, researchers Benigno C. Valdez, Apostolia M. Tsimberidou, Bin Yuan, Yago Nieto, Mehmet A. Baysal, Abhijit Chakraborty, Clark R. Andersen, and Borje S. Andersson from The University of Texas MD Anderson Cancer Center explored various combinations of HDACi and PARPi +/− decitabine (hypomethylating agent) in pancreatic cancer cell lines BxPC-3 and PL45 (wild-type BRCA1 and BRCA2) and Capan-1 (mutated BRCA2). “[...] we explored various combinations of HDACis and PARPis, with or without decitabine, in pancreatic cancer cell lines.” The combination of HDACi (panobinostat or vorinostat) with PARPi (talazoparib or olaparib) resulted in synergistic cytotoxicity in all cell lines tested. The addition of decitabine further increased the synergistic cytotoxicity noted with HDACi and PARPi, triggering apoptosis (evidenced by increased cleavage of caspase 3 and PARP1). The 3-drug combination treatments (vorinostat, talazoparib, and decitabine; vorinostat, olaparib, and decitabine; panobinostat, talazoparib, and decitabine; panobinostat, olaparib, and decitabine) induced more DNA damage (increased phosphorylation of histone 2AX) than the individual drugs and impaired the DNA repair pathways (decreased levels of ATM, BRCA1, and ATRX proteins). The 3-drug combinations also altered the epigenetic regulation of gene expression (NuRD complex subunits, reduced levels). “This is the first study to demonstrate synergistic interactions between the aforementioned agents in pancreatic cancer cell lines and provides preclinical data to design individualized therapeutic approaches with the potential to improve pancreatic cancer treatment outcomes.” DOI - https://doi.org/10.18632/oncotarget.28588 Correspondence to - Apostolia M. Tsimberidou - atsimber@mdanderson.org Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28588 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Robert Towarnicki, CEO and Co-founder of SIRPant Immunotherapeutics, discusses cancer-specific immunotherapy for aggressive tumors, the role macrophages play in the immune response to cancer, and how cancer cells can shut down this response. SIRPant Immunotherapeutics aims to modify macrophages by reducing SIRPα expression, triggering them to eat cancer cells and educate other immune cells. Early evidence demonstrates potential effectiveness for various cancers, including non-Hodgkin's lymphoma and solid tumors. Robert emphasizes this therapy's scalability and cost advantages compared to other cell therapies like CAR-T. He also highlights the potential for treating rare diseases and the ability of SIRPant-M to target a wide range of cancers without the need for pre-identified targets. Robert explains, "Macrophages are a normal immune cell type in your body. They normally function to recognize foreign invaders and process them in the sense of phagocytizing or eating the foreign protein and invader, if it's a virus, a bacteria, or a cancer. Unfortunately, cancers are very good at shutting down this immune response. So, we need to modify the macrophage and re-empower it to elicit the other immune cells in the body to do their job and eliminate cancer." "I think one of the mistakes we've seen with others working with the macrophage in this situation was the lack of appreciation for the role of SIRPα. Our inventor, Dr. Yuan Liu at Georgia State University, identified this early on through a knockout mouse, a mouse where SIRPα was genetically removed from it. With that mouse, she could discover and learn how macrophages function and react. It directed us to the whole concept of removing SIRPα from the macrophage. Now, removal alone is not enough. You also have to activate a macrophage. So, a macrophage exists in multiple states. There's an active state, and then there's an inactive state." #SIRPant #Immunotherapy #Macrophages #Oncology #Cancer sirpantimmunotx.com  Listen to the podcast here

Robert Towarnicki, CEO and Co-founder of SIRPant Immunotherapeutics, discusses cancer-specific immunotherapy for aggressive tumors, the role macrophages play in the immune response to cancer, and how cancer cells can shut down this response. SIRPant Immunotherapeutics aims to modify macrophages by reducing SIRPα expression, triggering them to eat cancer cells and educate other immune cells. Early evidence demonstrates potential effectiveness for various cancers, including non-Hodgkin's lymphoma and solid tumors. Robert emphasizes this therapy's scalability and cost advantages compared to other cell therapies like CAR-T. He also highlights the potential for treating rare diseases and the ability of SIRPant-M to target a wide range of cancers without the need for pre-identified targets. Robert explains, "Macrophages are a normal immune cell type in your body. They normally function to recognize foreign invaders and process them in the sense of phagocytizing or eating the foreign protein and invader, if it's a virus, a bacteria, or a cancer. Unfortunately, cancers are very good at shutting down this immune response. So, we need to modify the macrophage and re-empower it to elicit the other immune cells in the body to do their job and eliminate cancer." "I think one of the mistakes we've seen with others working with the macrophage in this situation was the lack of appreciation for the role of SIRPα. Our inventor, Dr. Yuan Liu at Georgia State University, identified this early on through a knockout mouse, a mouse where SIRPα was genetically removed from it. With that mouse, she could discover and learn how macrophages function and react. It directed us to the whole concept of removing SIRPα from the macrophage. Now, removal alone is not enough. You also have to activate a macrophage. So, a macrophage exists in multiple states. There's an active state, and then there's an inactive state." #SIRPant #Immunotherapy #Macrophages #Oncology #Cancer sirpantimmunotx.com Download the transcript here

BUFFALO, NY- May 6, 2024 – A new research paper was published in Oncotarget's Volume 15 on May 3, 2024, entitled, “Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure.” Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell infection and cell-cell fusion that causes stabilization of tumor suppressor p53 protein. In-silico analysis previously suggested that SARS-CoV-2 spike interacts with p53 directly but this putative interaction has not been demonstrated in cells. In this new study, researchers Shengliang Zhang and Wafik S. El-Deiry from Brown University and Lifespan Health System examined the interaction between SARS-CoV-2 spike, p53 and MDM2 (E3 ligase, which mediates p53 degradation) in cancer cells using an immunoprecipitation assay. “We observed that SARS-CoV-2 spike protein interrupts p53-MDM2 protein interaction but did not detect SARS-CoV-2 spike bound with p53 protein in the cancer cells.” The researchers further observed that SARS-CoV-2 spike suppresses p53 transcriptional activity in cancer cells including after nutlin exposure of wild-type p53-, spike-expressing tumor cells and inhibits chemotherapy-induced p53 gene activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2. The suppressive effect of SARS-CoV-2 spike on p53-dependent gene activation provides a potential molecular mechanism by which SARS-CoV-2 infection may impact tumorigenesis, tumor progression and chemotherapy sensitivity. In fact, cisplatin-treated tumor cells expressing spike were found to have increased cell viability as compared to control cells. Further observations on γ-H2AX expression in spike-expressing cells treated with cisplatin may indicate altered DNA damage sensing in the DNA damage response pathway. The preliminary observations reported here warrant further studies to unravel the impact of SARS-CoV-2 and its various encoded proteins including spike on pathways of tumorigenesis and response to cancer therapeutics. More efforts should be directed at studying the effects of the SARS-CoV-2 spike and other viral proteins on host DNA damage sensing, response and repair mechanisms. “A goal would be to understand the structural basis for maximal anti-viral immunity while minimizing suppression of host defenses including the p53 DNA damage response and tumor suppression pathway. Such directions are relevant and important including not only in the context of viral infection and mRNA vaccines in general but also for patients with cancer who may be receiving cytotoxic or other cancer treatments.” DOI - https://doi.org/10.18632/oncotarget.28582 Correspondence to - Wafik S. El-Deiry - wafik@brown.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28582 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ MEDIA@IMPACTJOURNALS.COM

This episode is brought to you by Cozy Earth, Maui Nui, and Lumebox. We've heard about Dr. Thomas Seyfried's groundbreaking research and approach to cancer as a disease of metabolic dysfunction. Today's guest was inspired by Dr. Seyfried's metabolic approach and conducted his own research on brain cancer cells using ketone-based metabolic therapy and hyperbaric oxygen. His findings were mind-blowing! Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Dominic D'Agostino to discuss his extensive research on brain cancer cells placed in ketosis and under the pressure of hyperbaric oxygen. Dr. D'Agostino shares why his findings provide further insight into the idea that cancer cell growth can be metabolically managed. He also discusses how exercise and a low-carbohydrate diet can be used as metabolic therapies to reduce cancer risk. Dr. D'Agostino shares the critical tests we should focus on to assess our metabolic health and the essential supplements that can support ketosis.  Dr. Dominic D'Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology, where he develops and tests metabolic therapies, including alternative energy substrates and ketogenic agents for neurological disorders, cancer, and wound healing. While studying the effects of gasses on the brains of Navy Seal divers, he developed an approach for metabolically starving cancer cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation.   In this episode, Dhru and Dr. D'Agostino dive into (audio version / Apple Subscriber version): The most innovative approaches to cancer (00:00:11 / 00:00:11)  The metabolic approach to cancer (1:30/1:30) Using the hyperbaric approach in cancer patients (13:00/ 9:03) The results of Dr. A'gostino's studies on mice (17:00 / 13:50) How this research translates to patients (22:00 / 18:05) Why a ketogenic diet can be therapeutic (37:00 / 32:04) The role of exercise in cancer prevention (53:00 / 46:35) What lifestyle factors should we be doubling down on for prevention (55:00 / 50:14) Dr. D'Agostino's thoughts on a low carbohydrate diet (1:01:00 / 56:30) The therapeutic benefits of ketosis (1:11:00 / 1:06:40) Supplements that can support ketosis (1:19:00 / 1:12:43) How to measure for ketosis (1:24:00 / 1:18:30) Checking the status of your metabolic health (1:26:00 / 1:21:30) Where to find community (1:34:00 / 1:28:16) Also mentioned in this episode: Keto Start Donate to the University of Florida (Metabolic Therapy and Cancer Research #250244) Levels  To learn more about Dr. D'Agostino, follow him on Instagram, Twitter, or his website.  Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code DHRUP. Right now, Maui Nui Venison is offering my community 20% off your first purchase. Just go to mauinuivenison.com/DHRU or enter the code D-H-R-U at check out to get 20% off and up your high-quality protein today. Lumebox is offering my community $260 off their FDA-approved portable Red Light device! That's over 40% off! Go to thelumebox.com/dhru and get your Red Light device. 

In today's world, the sad reality is that we've become far more sedentary than previous generations, with most of our lives forced into desk jobs or innovations that encourage us to prioritize convenience over movement. In this episode, we're rewiring the way we think about movement - as a form of medicine against chronic disease. Meet Darryl Edwards, a movement coach and author who spent nearly two decades in the corporate world -- and realized something needed to change. Today, he is the founder of the Primal Play Method and a physical activity, health, and play researcher, specializing in combatting chronic lifestyle diseases that plague modern society. In 2019, Darryl's TEDxTalk, "Why working out isn't working out," garnered over a million views, exploring the root causes of physical inactivity and our inherent resistance to traditional exercise routines.In this episode, we talk about how modern sedentary lifestyles, with prolonged sitting and limited physical activity, are contributing significantly to the rise of chronic diseases. Darryl stresses that movement is not merely a form of exercise but a fundamental aspect of our health—a powerful medicine that can slash the risk of disease by up to 50%. We discuss the need for restructuring of daily routines to incorporate more active habits and natural movement throughout the day instead of relying entirely on 1-hour workout sessions. As a play researcher, Darryl believes that embracing our inner child is the key to fostering a more positive and playful attitude towards active movement. He shares his everyday morning routine, showcasing practical ways to infuse movement into daily life beyond traditional exercise formats. Tune in for an engaging episode with Darryl Edwards as he champions the transformative potential of playful movement and its profound impact of movement on immune function, cancer prevention, and overall longevity.HIGHLIGHTS[1:15] Why Natural Movement Matters[2:35] Darryl's TED Talk on Our Love-Hate Relationship with Exercise[4:20] How Being Sedentary Leads to Chronic Disease[8:00] Modern Society Is Making Us Sedentary and Sick[14:50] Why Embracing the Inner Child Is Necessary[18:38] Darryl's Everyday Morning Routine[24:25] The Community Power of Crossfit[26:15] Why Our 1 Hour Workout Is Not Enough[31:05] How Movement Is Medicine[38:44] Aeorebic Exercise and Its Effect on the Metastasis of Cancer Cells[41:40] Improving Your Immunosenescence and Immunosurvelillance With MovementGUEST LINKSWebsite: https://www.primalplay.com/Instagram: https://www.instagram.com/fitnessexplorer/LinkedIn: https://www.linkedin.com/in/fitnessexplorer/Youtube: https://www.youtube.com/fitnessexplorerWhy Working Out Isn't Working Out TEDx Talk: https://youtu.be/NoN2b-b2c0o?si=CJO_PaUKjsTwjzWvAnimal Moves: How to move like an animal to get you leaner, fitter, stronger and healthier for life: https://a.co/d/aRgNuOM30-day Animal Moves Challenge: https://courses.primalplay.com/p/animal-moves-challenge UPGRADE YOUR WELLNESSMarion Institute BioMed Course: biologicalmedicine.orgCode: beautifullybrokenSilver Biotics Wound Healing Gel: https://bit.ly/3JnxyDDCode: BEAUTIFULLYBROKENLightPathLED https://lightpathled.com/?afmc=BEAUTIFULLYBROKENCode: beautifullybrokenSTEMREGEN: https://www.stemregen.co/products/stemregen/?afmc=beautifullybrokenCode: beautifullybrokenGOT MOLD?: https://www.gotmold.com/beautifullybroken/Code: beautifullybroken10Flowpresso 3-in-1 technology: https://www.beautifullybroken.world/flowpressoMedical grade Ozone Therapy: https://lddy.no/1djnhCode: BEAUTIFULLYBROKENAquaCure Machine + Molecular HydrogenWebsite:https://eagle-research.com?ref=24931Code: beautifullybrokenDIY Home Cold Exposure: https://www.penguinchillers.com/product/beautifullybroken/My Favorite Sauna: Therasage https://bit.ly/39mTxwYCode: BEAUTIFULLYBROKENCONNECT WITH FREDDIECheck out my website and store:www.beautifullybroken.worldInstagram – https://www.instagram.com/beautifullybroken.world/YouTube: https://www.youtube.com/@BeautifullyBrokenWorld

At the European Society for Medical Oncology 2023 Congress, Dr. DeMichele presented results from the CLEVER study, which looked at ways to treat inactive breast cancer cells that remained in people who were previously treated for breast cancer. The results suggest that it might be possible to find and treat these inactive breast cancer cells, which could help prevent breast cancer recurrence (the cancer coming back). Listen to the podcast to hear Dr. DeMichele explain: how inactive breast cancer cells survive chemotherapy how the inactive cells wake up and cause a recurrence the results of the CLEVER study next steps for the research

HEALTH NEWS   ·         Predominantly plant-based or vegetarian diet linked to 39% lower odds of COVID-19 ·         Pumpkin Seed Oil Restores Female Hair Loss ·         Exposure to Residential Green Space and Bone Mineral Density in Young Children ·         Early menopause and HRT among hormonal factors linked to heightened rheumatoid arthritis risk ·         Little Known Chinese Herb & Iron Kill 98% of Cancer Cells in 16 Hours ·         Low fitness in youth increases the risk of cardiometabolic diseases in middle age

What is in the This Week in Science Podcast? This Week: Ancient Discoveries, NASA on UAPs, Tall Tall Trees, Ryugu Rocks, Scandalous Sports Supplements, Eating Plastic, Tickling Rats for Science!, Do power lines kill birds?, Mosquito-Friendly Gene Drive, Cooperation in Cancer Cells, Memory Rhythm, The Stop Spot, Robot Comedians, And Much More Science! Become a […] The post 2 August 2023 – Episode 937 – This is the Day After. Whatchya Gonna Do Science? appeared first on This Week in Science - The Kickass Science Podcast.

In this episode:00:45 Why losing the Y chromosome makes bladder cancer more aggressiveLoss of the Y chromosome in bladder cancer cells is associated with increased severity of disease, but the reasons behind this have been unclear. Now researchers show that the loss of this chromosome helps tumour cells evade the immune system. However, this mechanism also makes the cells more vulnerable to certain chemotherapy treatments, and the researchers hope their findings could help improve outcomes for patients in the future.Research article: Abdel-Hafiz et al.07:30 Research HighlightsHow pollution particles ferry influenza virus deep into the lungs, and why artificial lights could dazzle glow worms into extinction.Research Highlight: Flu virus hitches a ride with haze particles deep into the lungResearch Highlight: Glow-worms' ‘come-hither' signals are lost in the glare of human lights10:10 Engineering synthetic cartilageThe cartilage in our joints is able to withstand and dissipate a lifetime of impacts, protecting our bones and muscles from damage. But the mechanical properties of cartilage have made it difficult to mimic, and developing synthetic cartilage to replace damaged tissue has proved challenging. Now a team has developed a protein-based material that shares some of cartilage's characteristics, and shown its potential in helping heal damaged tissue.Research article: Fu et al.17:44 Briefing ChatWe discuss some highlights from the Nature Briefing. This time, how early magnetic minerals might help explain why nature shows a preference for the ‘left handed' or ‘right handed' versions of certain molecules, and how human's thirst for groundwater has made the North Pole drift.Science: ‘Breakthrough' could explain why life molecules are left- or right-handedNature News: Rampant groundwater pumping has changed the tilt of Earth's axisSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

How do Vitamin D and genomic ancestry impact cancer cells? Dr. Moray J. Campbell, a research scientist at Cedars-Sinai Cancer, joins the podcast to explain… Dr. Campbell is a cancer biologist who studies the genomic and epigenomic drivers of hormone-dependent cancers. By utilizing high-dimensional data approaches and bioinformatic analyses, Dr. Campbell is on a mission to uncover the scientific mysteries of cancer. Jump into the conversation now to find out: How Vitamin D and genomic ancestry influences prostate cancer.  How prostate cancer cells bind to patients depending on their genetic makeup. How gene expression in prostate cancer works. Where people get most of their Vitamin D from.  Want to learn more about Dr. Campbell and his research? Click here now! Episode also available on Apple Podcasts: http://apple.co/30PvU9C

Get ready to embark on an electrifying journey that will revolutionize your relationship with food and health!In this mind-blowing episode, you'll learn how to “Eat your way to better health." And who better to guide us than the extraordinary DR. WILLIAM LI—the world's foremost authority on the incredible power of food.Oh and yea , we're discussing Ozempic and similar injections AND Groundbreaking work on Cancer cells! This is something you have NEVER heard before!Dr. Li is about to unveil the secrets that will rock your understanding of nutrition and well-being. With over 40 FDA-approved breakthroughs under his belt, revolutionizing cancer treatment, cardiovascular health, wound healing, vision restoration, and NYT Bestselling book, his expertise is unparalleled.Brace yourself for this groundbreaking exploration of FOOD AS MEDICINE packed with game-changing insights that will directly impact your health—no matter where you are on your health journey!Prepare to take notes as we uncover:How to EAT your way to healthThe profound effects of EXTREME and FAD DIETING, both the good and the badThe dangers of relying on PRESCRIPTION DRUGS for weight lossA comprehensive exploration of ANGIOGENESIS and its implications for overall healthUnderstanding the critical role of HEALTHY BLOOD VESSELS in maintaining well-beingUncovering how food influences INFLAMMATION within the bodyAn eye-opening discussion on the daily formation of CANCER CELLS in our bodiesThe significance of embracing WHOLE FOODS to optimize healthThe impact of WHITE FAT AND BROWN FAT on our bodiesAND Dr. Li shares his cutting-edge research that will forever reshape your understanding of your body's metabolic processes and the connection between SLEEP, INTERMITTENT FASTING, and your body's ability to unleash its fat-burning superpowers.Dr. Li's groundbreaking insights on HARNESSING THE POWER OF EVERYDAY FOODS will activate your body's hidden potential, unleashing a new era of vitality and long-term health and revolutionize your well-being!

Conservative commentator and Author of ‘Trumponomics: Inside the America First Plan to Revive Our Economy,' Steve Moore discusses recent Big Tech layoffs being an indicator of the economy going into a recession and the natural resiliency of the US economy that can't be discounted. Moore reacts to what President Biden says of the economy versus the actual state of the economy, that “this economy now mystifies me on how it's holding up. And it has held up, you know, into last year. Not a good year for the economy, but it wasn't any kind of deep recession. And so it's, it's just hard for me to figure out where this economy's headed right now.” Moore goes on to say that “the good news, is that inflation is falling, no question about it, we've seen inflation go from, 9 to 10%, in the summer, to now [inflation is] down, in my opinion, probably about, about 4 or 5%. And, in fact, some of my friends who are very solid economists think that, they're almost more worried now about a deflation than an inflation.” He says that “job markets continue to hold up, to my surprise, jobs are still out there, notwithstanding what we just talked about with the tech industry, which is absolutely contracting.” The former economic adviser says he's “nervous about making any kind of definitive predictions about where [the US is] headed. I do I think that we've a lot of things are going wrong in this country from a policy point of view. Absolutely, I mean the debt, I think, is the cancer cell right now on our economy and very few people in Washington seem to be very concerned about it.” Moore's prediction on whether he thinks we're going to face a financial crisis is depended upon Washington's spending, “if this continues much longer, whether that financial crisis is going to happen six weeks from now, or six months from now or three years from now, I can't predict that, but it is. It is a precarious economy right now, it is hold up pretty decently but I don't know. And I'm not going to say that we're gonna have a recession in 2023 because even though most of the leading economic indicators are pointing South right now, there is a kind of natural resilience to the American economy that I wouldn't discount.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.