Podcasts about genes

Durante varios siglos han perdurado leyendas de criaturas nocturnas que se alimentan de sangre humana. El mito del vampiro mezcla lo humano y lo monstruoso, lo terrorífico y lo seductor, lo macabro y lo religioso.En este episodio haremos un recuento de los vampiros más famosos, pero además indagaremos en sus orígenes, escudriñaremos el misterio que los envuelve para encontrar sus debilidades... solo en caso que debamos enfrentar uno. 

Christina Shadle is a functional nutritional therapy practitioner (say that five times fast) aaaand she likes herself some wine (who doesn't?). But she also found that over time (literal time, we are talking aging, people), her tolerance and ability to bounce back from a few glasses of her favorite cocktail wasn't what it used to be. So she created her course, WELLNESS FOR WINOS, where the goal is to keep the cocktails and lose the consequences. She joins us to talk the good of habit stacking, detox and balance, and how a 14 day nourishing reset can be a life changer. It's 5 o'clock somewhere, am I right? Might as well enjoy it and feel good after doing so. This one is for the wine lovers out there (like me). _______________________________ Steve is busy at work on the third book in his cozy mystery series, THE DOG WALKING DETECTIVES. Grab the first two and get caught up: Book 1: DROWN TOWN Amazon: https://amzn.to/478W8mp Barnes & Noble: https://bit.ly/3Mv7cCk & Book 2: MURDER UNMASKED Amazon: https://shorturl.at/fDR47 Barnes & Noble: https://shorturl.at/3ccTy

Ever wondered what a genetic counselor actually does—or if you should talk to one? In this episode, Certified Genetic Counselor Laura Barton breaks it all down in simple terms. From inherited cancer risks to what your DNA can (and can't) tell you, this conversation makes genetic counseling easy to understand and incredibly empowering.Rate, Review & Follow to support Beyond Resilience. This helps us support more people and grow our community of resilient and like-minded people who want to move toward a more purposeful and healthy life.For more on Dr. Jamie Renbarger and her coaching practice, visit: https://jamierenbarger.com/For more on Catherine Haffey and her health and wellness platform, visit: https://catherinehaffey.com/For questions & comments, or to submit an episode topic request: beyondresiliencepodcast@gmail.comFollow Beyond Resilience on Instagram: https://www.instagram.com/beyondresiliencepodcast/Follow Beyond Resilience on TikTok:https://www.tiktok.com/@beyondresiliencepodcastFollow Beyond Resilience on YouTube:https: //www.youtube.com/@beyondresiliencepodcast

07 05 2025 A LA GRAN 730 - Claudio Genes, periodista ABC COLOR by ABC Color

07 05 2025 A LA GRAN 730 - Claudio Genes (Guido González, Intendente de Lambaré) by ABC Color

Producción y conducción: Sergio Garibay, Carlos Ortega y Ricardo Guzmán.Sistema Jalisciense de Radio y Televisión. Visita: www.jaliscoradio.com

Cada semana algo que contar, hablamos de Los Mayos con Eusebio Cabrera, además la Parranda Ixemad nos invita a su Festival por su XVI Aniversario y hablamos con Carlos De La Rosa. Desde el Distrito Suroeste de Santa Cruz de Tenerife, su Concejal, Javier Rivero nos cuenta sobre la Gala de Premios Suroeste Avanza. Y en La Laguna se presenta "Menopausia sin Reglas" y María Antonieta Hernández nos adentra en ese evento; nos vamos a escena con Zálatta Teatro y con el Festival de Teatro de Tegueste, y todo lo que nos ofrece Zálatta Espacio Escénico; recuerden que nuestras Bandas están en la Primavera Musical; todo en La Diez Radio con Joam Walo "poniendo lo canario más de moda que nunca y apostando por lo nuestro" #origenes #programaorigenes #ladiezradio #joamwalo

Welcome to Episode 254 of Autism Parenting Secrets. This week, we're spotlighting the hidden drivers behind chronic inflammation in kids on the spectrum, especially neuroinflammation.Our guest is Bob Miller, a functional genomics pioneer and founder of the NutriGenetic Research Institute. Bob unpacks the ways genetic weaknesses and environmental exposures collide to spark brain inflammation, behavioral challenges, and more.From mold and glyphosate to microplastics and EMFs, you'll discover the specific genes and pathways impacted, and how precision insights can guide what actually helps your child. This episode is deep, but empowering.The secret this week is…DECODE The Inflammation Puzzle You'll Discover:The Toxins That Flip The Inflammation Switch (4:13)Why Some “Healthy” Foods Make Things Worse (9:54)A Clear Breakdown of How Gene Mutations Affect Your Child (21:55)Why EMFs Deserve Your Attention (27:43)Nutrients That Actually Cool Inflammation (29:08)How Functional Genomic Analysis Reveals What To Do (35:02)About Our Guest:Bob Miller is a functional genomics researcher and the founder of the NutriGenetic Research Institute. For over a decade, he's led cutting-edge research on the link between genetic variants and chronic illness, including autism and Lyme disease.Through his educational platforms, including Functional Genomic Analysis software and a certification course for practitioners, Bob equips professionals worldwide with tools to decode the body's genetic blueprint.He's helped thousands understand how environmental toxins trigger genetic vulnerabilities—and how targeted nutritional support can turn the tide.Learn more: www.tolhealth.com and www.functionalgenomicanalysis.comReferences in The Episode:NutriGenetic Research InstituteFunctional Genomic AnalysisAutism Parenting Secrets Episode 109, Genes are CLUES, Not Destiny with Bob MillerAutism Parenting Secrets Episode 118, GENETICS Loads The Gun, ENVIRONMENT Pulls the Trigger with Bob MillerAdditional Resources:To learn more about personalized 1:1 support, go to www.elevatehowyounavigate.comTake The Quiz: What's YOUR Top Autism Parenting Blindspot?If you enjoyed this episode, share it with your friends.

06 05 2025 A LA GRAN 730 - Claudio Genes (Luis Ramírez, Ministro del MEC) by ABC Color

Episode Highlights With Dr. Anne Marie FineWhat happened with autism and why rates have risen from 1 in 10,000 to 1 in 31Some of the multi-faceted reasons that it might be on the riseWhat the literature actually says… you might be surprisedBeyond the genetic theory… the interaction between genes and environment Genes load the gun, environment pulls the triggerWomen with the highest BPA exposure had the highest risk of having children with autismThe CDC is actually keeping track of Americans' chemical exposureWhat to know about mercury and autism risk and how it was taken out of vaccines by 2001The specific study about the Hep B vaccine and why it's relevant Mercury was replaced with aluminum and why this is important How to become the EPA of your own home and avoid some of the biggest risk factorsResources MentionedDr. AnneMarieFine and emeiglobal on InstagramHer LinkedIn and her FacebookHow to Thrive in a Toxic World course: contains a bonus video presentation on environmental contributors to autism.Jaspr air filter - use code wellnessmama for a discountRadiant Life Water Filter

Welcome to the Triple P Life Podcast! Ever wondered why you're chronically tired, gaining weight despite your best efforts, or experiencing brain fog? It might not be age—it could be your hormones. In this eye-opening episode, hormone expert Donna White reveals the shocking truth: men desperately need estrogen and women absolutely need testosterone to thrive. What You'll Learn: The critical difference between synthetic and bioidentical hormones and why it matters Seven key symptoms that signal hormone imbalance (from sleep issues to memory problems) How proper hormone therapy can reduce heart disease risk by up to 52%, Alzheimer's by 52%, and diabetes by 30% Why hormone optimization isn't just for older adults—imbalances can start at any age The environmental factors causing a 50% decline in male testosterone over just 25 years Donna debunks dangerous myths about hormone therapy and cancer risk while explaining how proper hormone balance can dramatically improve your quality of life. Whether you're in your 30s struggling with fatigue or in your 60s wanting to maintain vitality, this conversation reveals why "normal" hormone levels aren't the same as optimal levels. Ready to take control of your health and feel your best at any age? Learn how bioidentical hormone replacement therapy could be the missing piece in your wellness journey. Don't accept declining energy and health as inevitable—discover what's possible when your hormones are properly balanced! Chapters: 00:00 - Introduction to Donna White and BHRT 02:43 - The Hormone Paradox Revealed 05:41 - Donna's Personal Journey with Hormones 08:23 - Defining Hormone Replacement Therapy Types 11:36 - The Hormone Crisis in America  15:33 - Male Testosterone Decline Crisis 17:35 - Balancing Hormones: Estrogen vs Testosterone 20:07 - Why Medical Professionals Ignore Hormones 23:51 - Testosterone and Heart Health 25:48 - Who Should Consider Hormone Testing  28:32 - The Seven Question Hormone Quiz 32:16 - Normal vs Optimal Hormone Levels 35:45 - Dr. Jay's Personal BHRT Experience 38:31 - Continuing Hormone Therapy Long-Term 39:57 - The Future of Bioidentical Hormones 42:28 - Research on Health Benefits of BHRT 46:34 - Genes vs Environment in Hormone Health 49:13 - Understanding Hormone Receptors 51:45 - Taking Control of Your Aging Process 53:36 - Final Thoughts on Hormone Health

  “Your DNA

05 05 2025 A LA GRAN 730 - Claudio Genes, periodista ABC COLOR by ABC Color

Abrimos la Academia de saberes inútiles con Marta Fernández, que nos retrotrae a los grandes apagones de la historia de la ciudad de Nueva York. También nos acompaña El Chojin para explicar cómo el apagón de 1977 propició el nacimiento del Hip Hop.

In this episode of the Startup Tri-Valley Podcast, hosts Yolanda Fintschenko, executive director of Daybreak Labs and i-GATE Innovation Hub, home of the Startup Tri-Valley (STV) Initiative, and Lisa Adamos, Economic Development Manager for the City of Pleasanton,  sit down with Reem Mahrat, a serial entrepreneur and founder of EazeBio. Reem shares her personal journey of battling autoimmune disease and how it inspired her to write the book "Feed Your Good Genes: Avoid Autoimmune Disease." She emphasizes the importance of empowering individuals to take control of their health through better choices and understanding gene expression.Reem discusses the innovative work at EazeBio, including the development of a novel biomarker that provides real-time insights into metabolic health. This biomarker helps patients see immediate results from their diet, exercise, and stress management, offering a personalized metabolic dashboard.Reem also highlights the significance of having a strong "why" in entrepreneurship and the importance of teamwork in achieving success.Tune in to hear Reem's inspiring story, her vision for transforming healthcare, and practical advice for founders balancing multiple roles and responsibilities. Watch on YouTube

My daughter Dalia taught me about courage, sweetness, patience, and love. I am who I am because of her.  We were meant to be together. -Jessica Fein Welcome to part two of my interview with Jessica Fein, author of Breath Taking:  A Memoir of Family, Dreams and Broken Genes.    Jess and her husband, Rob, adopted three children from Guatemala.  When their daughter, Dalia, began exhibiting balance issues and speech delays, genetic testing revealed a devastating diagnosis of MERRF Syndrome, a degenerative disease that affects the mitochondria and has no cure.  In this interview, Jess shares what life was like for her family, and the story is equal parts love and fear of the future. From age 9 to her death at 17, Dalia was an “eyes on patient,” which meant that either a parent or a specially trained medical professional had to have eyes on her 24/7.   Dalia couldn't swallow and required a tracheotomy, which meant she was also on a ventilator.  She could not speak and was fed through a tube.  Dalia couldn't walk and required a wheelchair.   As she got older and was completely bedridden, she lost her ability to move and couldn't communicate at all, including pointing, nodding, or even mouthing words.  At the core of this interview is Jessica's powerful life philosophy that “joy and sorrow can hold hands.”   Says Jess:   “Dalia showed me that we can be going through what feels like a horror movie and laugh and create meaning and joy.  We tried to have fun in any way we could, and she was leading that charge.   She wanted to be a kid, and we were going to give that to her. We all learned that it's okay to laugh, to smile, and to be happy. The joy we created became even more powerful because of the sorrow we had.”  Hit that download button as fast as you can. Jessica's story is overflowing with the power of love.  www.jessicafeinstories.com #motherhood #rarediseases #resiliency #family.

We're thrilled to welcome back Jaclyn Downs, expert in gene therapy and personalized wellness, for another powerful conversation!This week, Jaclyn dives deep into how your genetic makeup influences anxiety, oxytocin production, endorphins, and depression — and what you can do to support your emotional health naturally. Learn how family predispositions affect your mood, why some people are more prone to anxiety and depression than others, and how understanding your genes can help you create a customized path to greater peace and well-being.If you've ever wondered why emotional ups and downs run in families — or what you can do about it — this episode is a must-listen.Connect with Jaclyn Downs and dive deeper into her work >> here and follow her on Instagram @functionalgenomicsWhat did you think of today's episode?>> Say hello and share your thoughts!Be sure to join the Manifesting Clarity Facebook page where we talk all about the lessons we've learned on the journey thus far and action steps we can take to bring more clarity into our lives! Thank you for listening! We are beyond grateful for you.

"Estén quietos, y conozcan que Yo Soy Dios. Exaltado seré entre las naciones, enaltecido seré en la tierra" ( Sal. 46:10 ).Lucho Schneider y Sebastián Martínez. Musicalización: Claudio Graff

Hawk recaps his dinner with the Thursday Dumper himself, the guys talk about how many Genes there are, John Bonnes talks about the surging Minnesota Twins

Hawk recaps his dinner with the Thursday Dumper himself, the guys talk about how many Genes there are, John Bonnes talks about the surging Minnesota TwinsSee omnystudio.com/listener for privacy information.

WATCH REACTION EPISODE ON PATREON: https://www.patreon.com/JulianDorey (***TIMESTAMPS in description below) ~ Ben Lamm is an American serial entrepreneur & billionaire. He is best known for founding Colossal Biosciences with Harvard Geneticist George Church. Colossal utilizes genetic engineering and reproductive technology to attempt the de-extinction of extinct species. They recently recreated genetically modified dire wolves and seek to re-create the Woolly Mammoth in the next 5 years. Matt James is an exotic animal expert, zoologist & Chief Animal Officer of Colossal Biosciences. BEN & MATT's LINKS - Ben IG: https://www.instagram.com/benlamm/?hl=en - Ben X: https://x.com/benlamm?lang=en - Matt IG: https://www.instagram.com/m_walkerj/?locale=en_AE%2B2&hl=en - Colossal YT: https://www.youtube.com/@itiscolossal - Colossal Website: https://colossal.com/ FOLLOW JULIAN DOREY INSTAGRAM (Podcast): https://www.instagram.com/juliandoreypodcast/ INSTAGRAM (Personal): https://www.instagram.com/julianddorey/ X: https://twitter.com/julianddorey JULIAN YT CHANNELS - SUBSCRIBE to Julian Dorey Clips YT: https://www.youtube.com/@juliandoreyclips - SUBSCRIBE to Julian Dorey Daily YT: https://www.youtube.com/@JulianDoreyDaily - SUBSCRIBE to Best of JDP: https://www.youtube.com/@bestofJDP ****TIMESTAMPS**** 0:00 - Intro 1:23 - Paul Rosolie Tape Measure Story 3:24 - The 6th Global Extinction, Restoring Dire Wolf & Woolly Mammoth 13:43 - De-Extinction & Science / Tech Behind It, Red Wolves 23:15 - Rewilding New Species & Effect on Genes, Ancient DNA Coding Breakdown (White Rhino) 30:35 - Northern Quoll Extinction, Jabba the Hutt Toads 35:08 - GMOs are good? 37:24 - How Colossal Makes Money 43:18 - The net value of a Whale, “Jurassic Park” & “I Am Legend” Risk 52:02 - Lab Creation Debate vs Natural / Organic, Chinese Gene-Edited Child Controversy 58:12 - How Matt joined Colossal Biosciences team, $50 Million to Elephant conservation 1:02:00 - How Colossal turned Scientist “Haters” into Supporters & Why, Science “Semantics” 1:09:56 - Colossal Would NOT Exist without AI, Talking to critics 1:14:05 - Working on Extinct Species vs Endangered Species 1:17:06 - Woolly Mouse De-Extinction & How They Did It (EXPOSED) 1:23:59 - Colossal NOT Cloning, How Species are designated, Dire Wolves vs Gray Wolves 1:32:28 - Julian & Ben explain Built-in Media Manipulation of Colossal 1:39:20 - You can't clone a Woolly Mammoth, Colossal's Animal Safety Measures 1:43:15 - How Colossal Edited Dire Wolf Genes 1:47:28 - “Playing God” Debate 1:54:10 - Ben & Matt REACT to Paul Rosolie's Criticism of Colossal 2:04:26 - Artificial Wombs (Ex-Utero) 2:06:28 - Can Colossal Rebuild EVOLUTIONARY Behaviors? (Extinct Elk Example) 2:09:53 - Ben & Matt want to visit Paul Rosolie, Julian remarks on his Amazon Jungle visit 2:11:55 - Colossal's Re-Wilding Plan for Animals, Tasmanian Tiger 2:16:48 - Ben & Matt invite Julian to visit Colossal CREDITS: - Host, Editor & Producer: Julian Dorey - In-Studio Producer: Alessi Allaman - https://www.youtube.com/@UCyLKzv5fKxGmVQg3cMJJzyQ Julian Dorey Podcast Episode 297 - Ben Lamm & Matt James (Colossal Team - Dire Wolf) Music by Artlist.io Learn more about your ad choices. Visit podcastchoices.com/adchoices

[This episode originally aired on May 9, 2023]  Buddha nature, or “enlightened genes,” isn't something outside of us that we need to construct or to import  • it is a force of awakening that is within us, and it is quite simple and quite natural  •  it is like the strong determination of children to learn and to develop; it's almost a kind of discontent looking to awaken  •  traditional texts point to this inherent nature as the root cause of awakening  •  the second cause of awakening is the pivotal point where that cause from within meets a cause from without—when you meet a teacher or a spiritual friend, someone who recognizes this quality within you and mirrors it back to you  •  that meeting point is extremely important  •  the third cause is the confidence that ensues from that meeting point, the confidence and trust in your own nature  •  the fourth cause is discriminating awareness or wisdom-insight; it is the insight that cuts through the fog and the distractions that cover over our inherent nature  •  this wisdom cuts through false identities and fixations, disassembling the solid walls of ego that alienate us from our true nature.

En la primera conferencia del ciclo “La vida cotidiana en la antigua Grecia”, la catedrática de Arte Antiguo de la Universidad Autónoma de Madrid, Carmen Sánchez Fernández, explora el punto de vista y los tópicos de las mujeres en la antigua Grecia a partir de las imágenes del arte, donde aparecen representadas en el gineceo y también yendo a la escuela, trabajando o incluso en la palestra, y donde además no falta la presencia de mujeres inquietantes como heteras, ménades o amazonas.Más información de este acto

Tom Staniford talks about living with the MDP syndrome, an extremely rare genetic condition. MDP syndrome includes Mandibula hypoplasia, Deafness, and Progeroid features amongst its widespread features. Tom developed Type 2 diabetes as a teenager because of a loss of fat under the skin (lipodystrophy) despite being very thin and active.  Tom has used his communication and media skills to help other people with MDP syndrome get diagnosed and receive the right care.Send us a text

In this episode, we're busting the myth of genetic determinism and diving into the empowering science of epigenetics. Your genes are not your destiny! Just because something “runs in your family” doesn't mean you're stuck with it. I'm here to help you understand how your environment, lifestyle, and choices can influence your genetic expression and how you can take back control of your health and future. We'll explore why the “it's just my genes” mindset can hold you back, how your genes actually work, and how to create the right environment for your body to thrive. Let's shift from feeling powerless to feeling empowered!   What You'll Learn in This Episode: Why your genes don't dictate your destiny and what epigenetics is all about. How your environment and lifestyle impact your genetic expression. Why “it runs in the family” isn't the full story. The two key components of a healing mindset: hope and responsibility. How understanding your genetics can help you create an environment where your body thrives.   Resources Book your free call with me here If you want to work with me, I have spaces in my new program, Bloom. Beat the Sweet: Sugar Detox & Recipe Collection

My HoneyDew this week is comedian Kelsey Cook! Check out her latest special, Mark Your Territory, now available on YouTube and Hulu, and her podcast, Pretend Problems, co-hosted with comedian Chad Daniels. Kelsey joins me in the studio this week to highlight the lowlight of her mother's battle with frontotemporal dementia (FTD). We dive into the emotional and financial rollercoaster of caregiving, and how genetic testing plays a role in shaping future plans. Plus, Kelsey shares what it's like trying to land jokes in the world's saddest room. SUBSCRIBE TO MY YOUTUBE and watch full episodes of The Dew every toozdee! https://youtube.com/@rsickler SUBSCRIBE TO MY PATREON - The HoneyDew with Y'all, where I Highlight the Lowlights with Y'all! Get audio and video of The HoneyDew a day early, ad-free at no additional cost! It's only $5/month! AND we just added a second tier. For a total of $8/month, you get everything from the first tier, PLUS The Wayback a day early, ad-free AND censor free AND extra bonus content you won't see anywhere else! https://www.patreon.com/TheHoneyDew What's your story?? Submit at honeydewpodcast@gmail.com Get Your HoneyDew Gear Today! https://shop.ryansickler.com/ Ringtones Are Available Now! https://www.apple.com/itunes/ http://ryansickler.com/ https://thehoneydewpodcast.com/ SUBSCRIBE TO THE CRABFEAST PODCAST https://podcasts.apple.com/us/podcast/the-crabfeast-with-ryan-sickler-and-jay-larson/id1452403187 SPONSORS: GhostBed -Head to https://www.GhostBed.com/honeydew and use code HONEYDEW to get an extra 10% off your entire order Cure Hydration -Get 20% off your first order! Stay hydrated and feel your best by visiting https://www.curehydration.com/HONEYDEW and using promo code HONEYDEW

In this episode, we sit down with Dr. Matthew Dawson, the founder and CEO of Wild Health, and leader in genomics-based precision medicine. Dr. Matt breaks down what precision medicine truly means--how it goes beyond traditional healthcare to create highly personalized plans based on your unique genetic blueprint and blood work. We explore some of the most important genes to assess for optimizing health, performance, and longevity, including the ApoE gene. He shares powerful insights into the future of medicine and why understanding your genetics is crucial for extending healthspan. Plus, we open up about our own personal Wild Health test results and how they've shaped our individual wellness journey. This conversation is packed with actionable insights you won't want to miss!Dr. Matthew Dawson is the founder and CEO of Wild Health, a genomics-based precision medicine company, and the CEO of TruDiagnostic, an epigenetics testing lab. He has authored two textbooks, published over two dozen studies, lectured in over 20 countries, and won national awards for education and innovation. His passion is unlocking the secrets of the genome and epigenome and using them to optimize health and maximize healthspan. He lives in the woods with his wife, four children, and two dogs.SHOW NOTES: 0:31 Welcome to the show!3:57 Dr. Matt Dawson's Bio4:40 Welcome Dr. Matt to the show!5:14 What is “Precision Medicine”?7:14 Your genes are not your destiny11:09 Renee's experience with Bulletproof coffee11:38 MTHFR & Homocysteine12:43 Combining lab work with genetics17:24 Alzheimer's genetics20:32 What to do for APOE-3/422:56 Biomarkers for optimal health 24:28 Can you change your sleep chronotype?28:26 Genes for telomere length31:37 *ALIGN MAT*33:16 *PIQUE TEA*35:27 Boosting BDNF37:30 Something new about HbA1C!39:47 FOXO3 Gene for Longevity43:40 Blue Zones & social connection45:12 Testing Biological Age49:08 Caloric Restriction for Longevity51:42 The perfect diet for your genes53:25 Comparing macro tolerances57:37 Wild Health reports 59:12 Coming soon for Precision Medicine!1:04:16 His final piece of advice1:04:56 Thanks for tuning in!RESOURCES:Website: wildhealth.com - discount code: BIOHACKERBABESInstagram: wildhealthmdLinkedIn: Wild HealthMy Align Mat - discount code: BIOHACKERBABES to save $250Pique Tea - Save $ with this link!Puori - Save 20% with discount code: BIOHACKERBABESEffecty - Save $50 with discount code: BIOHACKERBABESOur Sponsors:* Check out Effecty and use my code BIOHACKERBABES for a great deal: https://www.effecty.com* Check out Puori: https://Puori.com/BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Francisco, el primer latinoamericano en ser elegido Papa, falleció el pasado 21 de abril.

2025年COMPUTEX以「AI Next」為主題，5月20日至23日於南港展覽館隆重登場！ 吸引1,400家國內外科技大廠、新創企業及加速器等夥伴共襄盛舉，同時舉辦多場精采活動，歡迎踴躍預登參觀！ 報名連結

Sharad P. Paul, MD, is a skin cancer specialist, family physician, evolutionary biologist, storyteller, social entrepreneur, and an adjunct professor at Auckland University of Technology. Born in England, with a childhood in India, he's a global citizen and a noted polymath. He received the Ko Awatea International Excellence Award for “leading health Improvement on a global scale, and his work towards patient-centered medicine across several countries.” He has authored works of fiction, non-fiction, poetry, and medical textbooks. His new book is Biohacking Your Genes: 25 Laws for a Smarter, Healthier, and Longer Life (Beyond Words Publishing, Oct. 14, 2024). Learn more at www.BiohackingYourGenes.com.      Tiktok: https://www.tiktok.com/@skininyourgame  Instagram: https://www.instagram.com/skininyourgame/ Youtube: https://www.youtube.com/channel/UCKnLlUo467jY_ievcB3iScg

“Y le fue dado dominio, y gloria y reino; y todos los pueblos, naciones y lenguas le sirvieron. Su dominio es eterno, que nunca pasará, y su reino nunca será destruido” (Dan. 7:14).Lucho Schneider y Sebastián Martínez. Musicalización: Claudio Graff

Host: Denise M. Dupras, M.D., Ph.D. Guest: Michael Zimmer, Ph.D., Director of Rare Diseases at Moderna Therapeutics This episode of Genes & Your Health welcomes Dr. Michael Zimmer from Moderna Therapeutics, who discusses how mRNA technology is being applied to treat rare genetic diseases, especially liver-based metabolic disorders. Dr. Zimmer explains how mRNA can help the body produce missing proteins, the challenges of delivering these therapies, and the promise they hold for previously untreatable conditions. Connect with us and learn more here: https://ce.mayo.edu/online-education/content/mayo-clinic-podcasts 

We spent five years trying to have a baby and then decided to make the switch from baby making to family making - Jessica Fein We're back in my cozy living room for this episode of The Story Behind Her Success. I'm learning that when you're sitting on a comfy couch with the fire going, the time you spend together feels more like a chat between friends and less like a formal interview. An author, marketing executive, and former opinion columnist for the Boston Globe, Jessica Fein's book, Breath Taking: A Memoir of Family, Dreams and Broken Genes, will give you new reasons to believe in the resiliency of the human spirit. In Part One of this interview, Jessica tells the story of how she and her husband, Rob, spent five years trying to have a baby. When nothing worked, they turned to adoption, and were so overjoyed with their decision, they wondered why they hadn't made it sooner. Over the next few years, the couple welcomed three beautiful babies into their home, all of whom were from Guatemala. It was baby heaven with Jonah, Dalia, and Theo for a while, until the little voice inside Jessica's head got louder and louder. Call it a hunch, or mother's intuition, but Jessica knew that something just wasn't right with Dalia. As a toddler, she fell down a lot, and her speech was delayed. Repeated tests by early intervention experts showed that Dalia was on the lower end of normal, but as time went by, Jessica persisted. Finally, Dalia's hearing was tested and showed moderate hearing loss. Now in kindergarten, Dalia had hearing aids, but continued falling down. Since she was adopted, doctors suggested that Dalia undergo genetic testing, and the result was devastating. Five-year-old Dalia was diagnosed with a degenerative, rare disease with no cure called MERFF, which impacts the ability of the body's organs to function. MERFF is degenerative and has no cure. 2 children in 1 million will get this disease, and Dalia had yet another layer of the disease, making her 1 of only six known cases in the world. With this news, Jessica and her family began a journey filled with overwhelming fear, sorrow, and a belief that in life, we must find reasons to laugh in order to capture joy wherever we can. For a 21-minute story that will leave you breathless, just hit that download button. #rarediseases #motherhood #storytelling #adoption

In this episode of Behind the Genes, we explore how ethical preparedness can offer a more compassionate and collaborative approach to genomic medicine. Drawing on insights from the EPPiGen Project, our guests discuss how creative storytelling methods, like poetry, have helped families and professionals navigate the complex emotional, ethical and practical realities of genomics. Our guests reflect on the power of involving patients and families as equal partners in research, and how this can lead to more inclusive, empathetic, and effective care. The conversation explores how ethics can be a tool for support, not just regulation, and how creating space for people to share their stories can have a lasting impact on healthcare delivery. Our host for this episode, Dr Natalie Banner, Director of Ethics at Genomics England is joined by Professor Bobbie Farsides, Professor of Clinical and Biomedical Ethics and Dr Richard Gorman, Senior Research Fellow, both at Brighton and Sussex Medical School, and Paul Arvidson, member of the Genomics England Participant Panel and the Dad's Representative for SWAN UK. Paul shares his poem 'Tap tap tap' from the Helix of Love poetry book and we also hear from Lisa Beaton and Jo Wright, both members of the Participant Panel. "The project gave us the tools to find a different way to get at all of those things inside of all of us who were going through that experience... It's almost like a different lens or a different filter to give us a way to look at all those things, almost like a magnifying lens; you can either hold it really close to your eye and it gives you like a blurry view of the world that goes on and you can relax behind that and find a way to explore things in a funny way or an interesting way, but you can also go really close into the subject and then you've got to deal with the things that are painful and the things that are difficult and the things that have had an impact." You can download the transcript, or read it below. Natalie: Welcome to Behind the Genes. Bobbie: In an earlier conversation with Paul, he used the word ‘extractive,' and he said that he's been involved in research before, and looking back on it he had felt at times it could be a little bit extractive. You come in, you ask questions, you take the data away and analyse it, and it might only be by chance that the participants ever know what became of things next. One of the real principles of this project was always going to be co-production and true collaboration with our participants. Our participants now have a variety of ways in which they can transport their voices into spaces that they previously found maybe alienating, challenging, and not particularly welcoming. Natalie: My name is Natalie Banner, I'm the Director of Ethics at Genomics England and your host on today's episode of Behind the Genes. Today I'll be joined by Paul Arvidson, a member of the participant panel at Genomics England, Professor Bobbie Farsides, Professor of Clinical and Biomedical Ethics at Brighton and Sussex Medical School, and Dr Rich Gorman, Senior Research Fellow, also at Bright and Sussex Medical School.  Today, we'll be exploring the ethical preparedness in genomic medicine or EPPiGen Project. This project examined how the promise and challenges of genomic medicine are understood and experienced by the people at the heart of it, both the clinicians providing care and the patients and families involved.  A big part of the EPPiGen Project explored using creative methods of storytelling and poetry to explore the experiences of parents of children with rare genetic conditions.  We'll discuss why the idea of ethical preparedness is crucial in genomic medicine to acknowledge the challenges and uncertainties that often accompany the search for knowledge and treatment in genomic healthcare, and to help professionals develop the skills to navigate the complex ethical considerations.    If you enjoy today's episode we'd love your support. Please like, share and rate us wherever you listen to your podcasts. Is there a guest you'd really like to hear on a future episode?  Get in touch at podcast@genomicsengland.co.uk. So, I'm going to ask our fantastic guests to introduce themselves.  Paul, would you like to go first? Paul: Hi, I'm Paul Arvidson. As well as my Genomics England hat, I've got a SWAN hat as well, I'm the dads' rep for SWAN UK, and I'm on the poets from the EPPiGen Project.  Natalie: Brilliant to have you hear today. Thanks, Paul. Rich?  Rich: Hi, I'm Rich Gorman, I'm a Senior Research Fellow at Brighton and Sussex Medical School and I've been working on some of the research on the EPPiGen Project that looks at people's social and ethical experiences of genomic medicine, and particularly families' lived experiences of genomics.  Natalie: Brilliant. Really looking forward to hearing from you. And Bobbie?  Bobbie: Hello, I'm Bobbie Farsides, I'm Professor of Clinical and Biomedical Ethics at Brighton and Sussex Medical School and co-PI with Professor Anneke Lucasson of the Wellcome Trust funded EPPiGen Project, and it's been my pleasure and privilege to be involved in the work that we're going to talk about today.  Natalie: Really fantastic to have the 3 of you here today. So, we're going to take a slightly unusual approach to starting the podcast today and we're going to begin with Paul who's going to read us a poem from the book Helix of Love. Paul, over to you.  Paul: This is called Tap, Tap, Tap.  ‘Tap, tap, tap, I hold the egg to my ear. There it is again, tap, tap, tap. Run to get a torch and light through the shell, to see who's tapping from within. Chicken's home from work these days just for fun and the odd egg. Market stalls swapped for medicines, cash boxes for cough machines. We kept the apron though. Profound learning disability is our life now, most of it, learning about it, learning from it, surviving with it, despite. It's a subtle egg though, this. The shell is there, invisible, but there's a person inside, tap, tap, tap.  What are you trying to tell us about what the world's like for you? Are you bored? Do you hurt? Is your sister a love or a pain? Tap, tap, tap. I wish I could set you free.'  Natalie: Thank you, Paul. Such beautiful and powerful words. I wonder if you wouldn't mind telling us a little bit about that poem and your journey and maybe touch on what the EPPiGen Project has meant for you.  Paul: Wow, that's a lot to unpack in one go. I suppose the oddness of the metaphor is probably worth a mention. The way the project worked is that Bobbie and Rich collected together a proper poet, Dawn Gorman, and she led us through the process of kind of, she basically taught us all to be poets from scratch, it was… When you say it like that it was a hugely audacious project really to just collect all these randoms together in a room and throw a poet at them and see what happened.   And they trusted us, I suppose, and trusted Dawn that there was going to be something came out of this. But one of Dawn's techniques was that like each week we did… I think we did… Did we do 6 weeks, chaps? Which felt like a huge amount of time, but it went in milliseconds. But what she did every week was that she gave us either a poetic form to work with, like, you know, “This week we're going to learn how to do a haiku, or a sonnet,” or whatever, or she'd gone away and thought of a particular poem that she thought might resonate with us and then she'd bring that to the session. And she'd read a poem out and then say, “Right, what did you make of this? Go away and write what it inspires you to write.”    So, the poem that I wrote was, the inspiration for that session was a poem called The Egg by Richard Skinner. His poem was more about the form of the object itself, so, although that sounds really abstract, it really, really helped. So, every week it would be like Dawn threw this object into the group and said, “Right, okay, here's your new prompt, bosh, off you go.” And although that sounds like the most obscure way to deal with anything, because you get a structure around which to organise your thoughts it was just this like hugely powerful thing for everybody.    And so, the thing that came to mind for me was the metaphor of the egg rather than the egg itself and it just kind of chimed with all of us. Like we used to run the egg stall in Minehead farmers' market and so, I married into a country girl and so she had like 200 laying hens at one point, and so we had this whole market stall antics but also it spoke to so many things in one hit. So we gave up that part of our lives as our daughter Nenah's condition became more and more complex.    She was always, once we knew what her genetic condition was one of the few things that we knew from the get-go was that it was progressive. So we knew in advance that that was the case, but we didn't know what that meant. And so slowly but surely one of the things we had to do was give up our working life, you know, one week and one hour at a time, it felt. So part of the poem's about that as well, the shift in the poem from the comedy bit to the beginning to the more serious bits at the end, and it kind of felt like we gave those things up day by day but the poem kind of got to speak to that.   And then there's also the metaphor. Once you've got a good metaphor it's always good to run with it, you know? And so the idea of the metaphor of somebody who's got profound learning disabilities and can't speak being inside this shell and as parents you're always kind of peeking in from the outside to see what's going on within or to try and find ways, the idea of when you're checking to see if you've got a chick inside your shell, and you do this thing called ‘candle' where you hold the light to it, that I describe in the poem, and you like hold it to your ear and hear if there's movement going on inside. And you kind of, I don't know, I felt with a profoundly learning-disabled child that you always feel like you're doing that as a parent as well to see if what you're doing is, you know, if you're still communicating while you're trying to be a parent.  Natalie: Fantastic. Thank you so much for sharing that with us, Paul, both the poem and also your exploration of how you got to that point in writing that poem.  Tremendously powerful to kind of understand and hear about that experience.  Bobbie, if I can come to you. Paul referred to that project as kind of audacious, can you tell us a little bit about the origins of the Helix of Love but also why storytelling, especially through poetry, was so important for the EPPiGen Project?  Bobbie: Yes, of course, Natalie. But can I start by saying I was so pleased that you got Paul to speak for a while after because I always have to compose myself after hearing these poems because they really do hit so powerfully, however many times you hear them. And I think that is part of what we wanted to achieve with this project, we wanted to use innovative research methods, we wanted to be…  I love the word ‘audacious'; I'm going to borrow that.  We wanted to be audacious; we wanted to be courageous, and let me tell you, our Ethics Committee were a little bit worried about the sorts of things we told them we wanted to do. But we knew because we live and work in Brighton that the world is full of creative people and we'd already had such wonderful partnerships with people over the years, we knew that we could draw people into this project who would help us to work with this fabulous group of parents ,in a way that would give them, as Paul says, an opportunity to explore their own feelings and their own experience and share it as they wished.    In an earlier conversation with Paul, which he might find surprising that it's stuck with me so much, he used the word ‘extractive' and he said that he'd been involved in research before and looking back on it he had felt at times it could be a little bit extractive. You come in, you ask questions, you take the data away and analyse it and it might only be by chance that the participants ever know what became of things next. One of the real principles of this project was always going to be co-production and true collaboration with our participants, and the poetry project probably wouldn't have come about if it hadn't been for the passion of one of our participants who was sort of finding a love for poetry herself and said, “Can we try this next?” So, you know, it means so much to Rich and I that we ended up with this amazing book, but it's not our book, it's our poets', as we like to refer to them, book.   So, one of the things that we are so pleased about in this project is that our participants now have a variety of ways in which they can transport their voices into spaces that they previously found maybe alienating, challenging, and not particularly welcoming. And I think another wonderful upshot from this project has been how receptive people have been to the work. And it's a sort of commonly held myth that your average philosophy article has a readership of 3.4 people. Rich created a wonderful map to show how Helix has travelled round the world and touched thousands of people – I don't think that's an exaggeration – and we couldn't be more grateful for that as researchers because we feel as passionately about these subjects as our participants and it is they who have really got this project on the map. Paul, you were going to come in, I hope.  Paul: I feel like the one thing that this project really did was, I know PPIE is a phrase that's bandied round but this project kind of stripped that theme apart and took the ‘I' bit, this project is like built around inclusion and because it felt like, if we'd have just been jumping in a room with Dawn and told to get on with it, I don't think it would've worked as well. The idea that it was kind of curated by Bobbie and Rich, we very much felt like our hands were held through the process, and after them having had to kick down doors in the Ethics Department to be able to get the project through at all, it's like “What are you going to do to these poor parents?” having gone through that process themselves behind the scenes, then to kind of feel like we were guided through this process. And we were guided and held, and they were super-aware of all of us. And the fact that every time you tell these stories as a parent who's gone through them there's a cost. And we've had this discussion with the panel before and the communication group, about the fact that every time you come to a parent and say, “Tell us your story” there's a cost.   And so, they were aware of that, and they held that in both of their hands and so it couldn't have been anything other than this collaborative project by the time we'd finished.  Advert: The Genomics England Research Summit is fast approaching and registration is now open! Join us for this one day in-person event on Tuesday 17 June 2025. This year's agenda dives into rare condition diagnosis, cancer genomics, pharmacogenomics, therapeutic trials, and the impact of emerging technologies. Hear from leading experts and inspirational speakers as we explore the present and future of genomics and the latest research and technology from the Genomics England research community. Keep an eye on the website, genomicsresearchsummit.co.uk for all the details and to secure your spot. Spaces are limited, so don't miss out. We'll see you at the summit! Natalie: We're going to hear a clip from Lisa Beaton, a member of the participant panel at Genomics England, who shares what it has meant for her to take part in the project.  Lisa: It was an amazing opportunity. I had a huge sense of imposter syndrome actually when I as invited to join, because I was aware of some of the people who'd already taken part in the project and although I can bring lived experience to the table I don't really consider myself as a creative writer or anything like that, although I do enjoy it. When I first started in the group, we were just doing free-flowing writing. It was really cathartic, and I didn't expect that in any way, shape or form. To put pen to paper without necessarily having any strategy in mind, just letting the thoughts come out and ramble away, I didn't really know what was going to come blurting out onto my notepad, and reading some of it back was moving but it was frustrating. It was moving, it was everything really, that opportunity just as a safe space, knowing I didn't have to share it with anybody if I didn't want to but I could, and I could just, I suppose I would call it almost like a brain fart, it just rambled away and maybe it was a way of downloading some of the emotions that I was carrying.   As the project went on and we explored different creative mediums I really enjoyed that and found different skills that I wouldn't have thought about. And it was very thought-provoking, being able to go back and think about some of our very early experiences, which is, not that I've buried them but it's just you move on to deal with the here and now, and it brought me back to some of those very raw emotions of the first days which I think are, I hope, helpful to certainly the medical community in terms of thinking about how they talk to new parents going through similar situations. I was very grateful.  Natalie: Rich, I'd like to come to you now. As Bobbie and Paul have both mentioned, the outputs for this project have really spread far and wide and maybe beyond the kind of academic circles that you might typically think. I'd really like to hear from you about how you think the project has helped healthcare professionals, particularly really enabling them to understand a little bit more about what it means to be part of a genomic healthcare service and the journey that patients and families go through. Would you share a little bit about your experience in the project, particularly for healthcare professionals?  Rich: Yeah, I mean, that was one of the things that when Bobbie and I set out to do this, that was one of the real aims, was to sort of help healthcare professionals have a bit more of an insight into what it means to access genomic medicine services from a patient or family perspective. And, as Bobbie said, there were 2 ways we could have gone and done this; we could've done some sort of conventional social science interviews, written that up in a lovely social science or philosophy journal article and no one would've probably read it, but instead we thought about the power of the arts to actually change in terms of how we were sort of collecting and collating people's stories and then how we were sharing and disseminating those stories as well. And I think the medium by which stories are told affect the kind of stories that get told, as Paul was sort of hinting at earlier.    When we ask patients to tell us their story, you know, there's a level of expectation there about what people are being asked to say in a form in a way, and certainly we didn't get people in a room and say, “You must write about genomics.” So many of the poems in the collection aren't really about sequencing or big data, they're about these kind of much wider themes of everyday life. And I think that's been really powerful in allowing healthcare professionals to sort of understand for patients obviously genomics is really important but it's not the be all and end all of everything that's going on in their lives, you know, there are so many other pressures, so many other hopes and desires, and people want an opportunity to express some of those positive aspects of their life with their loved ones and it not just be medicalised all of the time.    Again, as Bobbie said, it's also opened up our research travelling really well and just become something that's really accessible for people to pick up and read through, and I've had conversations with healthcare professionals that have said, “Oh I read through the book of poetry and it's made me realise all of these things.” Language particularly has been a really prominent theme that people have reported, telling us they've learnt a lot about it, and thinking about how they write their letters and how they communicate with people. And obviously this isn't new, you know, bioethicists for years have been talking about the need to communicate very carefully, very precisely and in a caring way, but I think there's something about communicating those messages through a really powerful art form like poetry through patients' own words that allows clinicians and healthcare professionals to sort of really get the impact of that in a very, very powerful way.  Natalie: Thanks, Rich, really helpful insights there. I really want to pick up on your point about language and come back to Paul on that because I know that's a topic area that can often be, you know, hugely sensitive to families that the medicalisation, the terminology that's used, especially, you know, complex areas like genomics, coming back to this term we mentioned earlier about being sort of alienating. How have you found that the work through the EpiGen project and Helix of Love, has it potentially helped the way that families can think about the right sorts of language and enable health professionals to sort of approach some of these questions in a slightly more human way? Paul: Difficult to say. It's a very, very live topic all the time. There's like a backchat communications channel with the Genomics England panel where, because we all go along and do this thing, but we all share that genomics common thread in our lives. One parent was breaking their heart about the fact that they'd had sight of genetic science reports that basically described their child, and children like them as ‘lumped together' in a project, and she was gutted about it. And we all were as well, and we were all open-mouthed about it. The whole idea of kind of separating the science and the science language out from the people who are involved, it is our job, isn't it, you know, our job as the panel members is to remind people that those are people, not statistics. But it's a really live subject and the more people, the more professionals who can be reminded of that on a daily basis and the more we can find kind and open ways to deliver that message to professionals, and every single day that we do that makes a difference, I think. If one parent has to get less of a letter like that or one professional thinks more carefully about how they phrase stuff before it goes out the door, then that's one less parent who's got to go through that.  Natalie: Absolutely. And I'm thinking about that insight. I suppose the anticipation and the realisation to healthcare professionals about the impact of the way they approach things, the language they use, the kind of mindset they might adopt with parents and families, one really important aspect of the project was to do sort of preparedness and the idea that you should be able to anticipate and plan for and acknowledge some of the ethical challenges that might come through when you're dealing with questions of genomic healthcare where there may be lots of uncertainty, there may be a long journey to go through.   Bobbie, can I come to you to help us unpack this notion of ethical preparedness as a core theme for EPPiGen? Help us understand what that means in kind of simple terms and why does it matter for those who are working in the genomic medicine and healthcare space.  Bobbie: I think the way in which most people will have heard of this concept of preparedness is in relation to disaster planning. We know that some of the good things we try and do in life are also potentially fraught with challenges and difficulties just because of their complexity and because of the wide range of people and organisations that will be involved. Can we take this idea of preparedness and almost say, “You have a moral responsibility to be ethically prepared when, for example, you embark upon a really dramatic change in healthcare delivery or an introduction of fantastic new healthcare innovation”?    And genomics seemed to be the perfect case study for this. We then had to say, “What does that actually mean in practice?” And I think here we wanted to move away from the idea that you can ethically prepare people by putting a small albeit very expert and clever group of people in a room to write guidance and regulations, those things are needed and they're useful. But it's actually much more important to almost recruit everybody, to bring everybody up to speed, so that the ethical challenges aren't a complete shock to those who are delivering the service in the frontline, so that those who plan systems actually think whilst doing so of the ethical challenges that can be posed by the tasks they're attempting to achieve.    And I was a sort of founder member of the Ethics Advisory Committee at Genomics England, and it was so interesting in those early days because there were no patients, there were no participants. We were sitting alongside people whilst they designed and put in place basic processes, strategies and ethics was a part of that. And a really important part of that to me, at those meetings, was hearing what the potential participants had to say about it because, again, the Participant Panel was involved. And I found that those were my people, those were the people who were worrying about, concerned about the same things as I was.  So, I think to be prepared we have to take on the responsibility of giving people who work in ethically challenging areas opportunities to come together to acknowledge the complexity of the task, to share strategies and tools, but also, very importantly, to not become divorced from the people that they are attempting to serve, because in fact we feel that this part of our project, and our project is much bigger than this and we've done some fantastic things working with healthcare professionals, medical scientists, etc, etc, but this part of the project is an attempt to say, “We can better prepare families as well by ensuring that we tell them that their voices are valuable, that they're important, and they help rather than hinder healthcare professionals in doing their jobs.”  Natalie: That's a really important point around the idea that this approach can help, can be positive. Because I think sometimes you think about preparedness and, and quite often with ethics it's about risk, it's about, you know, “How do we avoid the risks?” but there's a very positive story to tell about taking a more preparedness-type approach to thinking through ethical complexities, challenges and so on, both for health professionals and, as you say, for families. I wonder if you could just talk a little bit more about the kind of positive aspects that that can bring to everyone in that genomics healthcare journey, both the health professionals and the families.  Because I think sometimes it's easy just to think that it's mostly about sort of avoiding the risks and the pitfalls, and that might be harder to engage with people if you take that sort of risk-based approach.  Bobbie: Yeah, it's an interesting one. I think the ability to confront risk and uncertainty is a sign of maturity. And we find medical students, for example, hate any sense of uncertainty; they want to be told how to do something and they want to know that they'll be able to do that thing and get it right. And our job is often to say, “Well it's not going to be as easy as that, in fact it might be impossible, and here's what you have to do instead and here's how you allow yourself to fail or to not achieve in the way that you want but still do something really meaningful for the people that you're caring for.”  So, I think there's that aspect of saying, “It's part of medical education, it's part of how we should think in organisations that wherever you take risks, wherever you try to push frontiers, blur boundaries…”  I mean, genomic medicine has done something really interesting in terms of blurring the boundary between scientific research and clinical care. Wherever you do these things there are going to be challenges but those challenges, they're fascinating, they're interesting, they can bring us together. If we've got a shared will to get through them, you know, to make things work, then it's enlivens what you're doing; it's not a barrier.   I sort of began teaching and working in the space of bioethics right back in the ‘80s, which is a shock to you, I'm sure, but in those days I'm afraid that ethics was seen as a block, a barrier, a hurdle that people had to get over or through. And I think there's still a sensitivity, and certainly, I myself have been sort of challenged on critiques that I have offered to say, “Oh that's a bit harsh.” But I think what ethics attempts to do now, and certainly through really putting a positive spin on this idea of working together to establish ethical preparedness in important spaces, is to show that actually ethics can be very facilitative, it can be very supportive, and it can help people. It's not a surveillance mechanism, it's actually another clinical tool and something that, you know, people should seek support around.  Advert: If you're enjoying what you've heard today and you'd like to hear some more great tales from the genomics coalface, why don't you join us on the Road to Genome podcast, where our host, Helen Bethell, chats to the professionals, experts and patients involved in genomics today. In our new series, Helen talks to a fantastic array of guests including the rapping consultant, clinical geneticist Professor Julian Barwell about Fragile X Syndrome, cancer genomics and the holistic approach to his practice. A genuine mic-drop of an interview. The Road to Genome is available wherever you get your podcasts. Natalie: Rich, if I could come to you thinking about that reframing, I suppose, in your own research practice as an early career researcher, whether you're seeing that maturity in approach in thinking about some of these really complex, knotty ethical questions in genomics, are you seeing a greater appreciation for those?  And where do you think you're going to take your research as a result of this project in that space?  Rich: Yeah, thanks, that's a great question. Yeah, I think so, and I think one of the things that's really been revealing in this is the appetite for this kind of work in the sort of genomics sector, an appetite for thinking about the sort of complex ethical issues, for engaging with kind of arts-based research, for sort of finding new language and new spaces to involve patient and family perspectives and stories and think about how we can learn from them.    I think in the highly scientific, highly technical space of genomics we often assume that everyone wants numbers and hard data but actually I think the way that this work has travelled, the amount of invitations we've had to sort of exhibit this work and talk to healthcare professionals and scientists about this work shows that there's this really rich appetite for thinking about this complexity and doing that work of ethical preparedness, as Bobbie's talked about, and I think it's fascinating. And I know a lot of the participants who joined in our project have also sort of had opportunities from being involved in our work and found that there are people that want to listen to their voices and hear from them and learn from them as well. So that's been really exciting, and I hope it will continue and I hope there's opportunities for much more interdisciplinary collaboration in the genomics space with philosophers, with social scientists with ethicists, with artists and, importantly, with patients.    Paul: You mentioned the idea that certainly the poetry at the very least has allowed those voices to get into different spaces, and I think when those things first started happening it was when we at least as the people who'd written the poems felt that there was a huge big impact from this stuff. And I wasn't the first one to read one of these poems out loud, and in a way the collection of poetry became bigger than the sum of its parts in a funny kind of a way. And I can't remember but somebody read one of the poems at a conference somewhere and they said at the end of it that you could've heard a pin drop, and it was just that thought that actually with a big audience expecting kind of quite dry subject matter about genetics, to have felt that moment where the poem got launched off the stage and then it impacted on the audience and then, the way they described it, you could almost kind of feel them describing the ripples of the poem just like spreading out amongst this kind of silent audience and everyone kind of taking this kind of mental sigh of like “Oh that's what it feels like.” And the idea of that happening was when, for me anyway, when we knew that what we'd created was bigger than the sum of its parts and had its own legs, Bobbie and Rich had been the Dr Frankensteins of this kind of amazing, beautiful monster. Natalie: Obviously the poetry's got into your soul, Paul, the metaphors are fantastic. But just to make sure we bring in even more participant voices and perspectives into this we're just going to hear now from Jo Wright, who's another member of the participant panel, who's going to share what the project and the participant in it has meant for her.  Jo: So being part of the EPPiGen Project, it helped me to find my voice in an area that was relatively new to me, and also it was a way to take control of my own experiences rather than feel like I'm being swept along by a lot of systems.    And there were things that I really value that I thought contributed to making the project so successful. One was that they asked the question “What is this experience like for you, the experience of being part of a research project, the 100,000 Genomes experience of waiting, the experience of having your data in the library?” And no one had asked that before. You go to your appointments and you're in the system and, you know, it's kind of, everyone was finding their way to some extent because it was new for all the clinicians as well, but the fact that they asked, because no one asked that before, I don't have an outlet for that.     And then the other thing was that it was completely open so there was no research interview or questionnaire to answer, no expectation about what it was going to look like at the end. And I think working that way really strengthened the connection between us as parents of children with rare conditions and then also our relationships with Bobbie and Rich as the researchers and with the wider clinical community when they started to see our work and respond to it. So it was a way to understand people's individual experiences but it also made us feel connected and empowered through sort of like shared human experience, and that could be between us as the participants but also shared experiences between us and the researchers or us and clinicians and scientists that were looking at what we've done.  Natalie: So we've heard lots about the experience of participating in this fantastic EPPiGen Project, the kind of creative storytelling methods, the audacious methods that have been used, and some fantastic impacts beyond the kind of typical what could be quite dry sort of academic circles that this kind of work has spread out to.  I'd be really interested to hear from each of you about the takeaways, what you've learned, what's changed for you and what you'd like our listeners to really understand about this project and the work, and the sort of outputs from it and the ways it might continue to have resonance and impact going into the future, so whether people are patients, families, clinicians, researchers. What would you like people to remember and what's affected you most about the project?    Bobbie, I might start with you.  Bobbie: I think we have to always be very careful when we get excited about something - and the ‘we' here are the people in the health community, the education community, etc - to remember. As Rich said earlier, that this is only ever going to be quite a small part of other people's lives. You know, we've all devoted big parts of our careers, our enthusiasm, to thinking about genomics, to working in this space. I would really like people to pick up the book and work to understand a bit better about the everyday lives, the hopes, the expectations, the fears of the families who may or may not get a diagnosis, may or may not get on a good treatment path, all of whom want the best for themselves and everybody else from this venture.    But, as Paul knows better than most, it won't come to everybody, and we don't want anybody to be forgotten along the way. The people that signed up for Genomics England as participants were pioneers alongside medics and the scientists, and in these early years we want their experience to be recognised, and their experience goes much beyond their interaction with Genomics England and, unfortunately, all the work that we've produced shows how many challenges families have to face to secure a good life for their children, and I just want us all to just keep that in mind.    Natalie: Incredibly important to maintain that focus, that awareness. And, as you say, Bobbie, there's an interesting balance where there is a need for the drive and the innovation and the ambition to help ensure that we are pushing at the forefront of medical research but not leaving people behind and not ever forgetting, as you say, the experience of people who are actually at the forefront of this research and of genomic healthcare.   Paul, could I ask for your perspectives on this, and particularly how you see patient voices being involved in the future of genomic medicine, especially in light of your experience in the EPPiGen Project?  Paul: I think the biggest surprise and biggest takeaway for me was the project gave me, I mean, I can't speak necessarily for all the other poets, but you only need the evidence in the book itself. They gave us the tools, the project gave us the tools to find a different way to get at all of those things inside of all of us who were going through that experience. So it gave us a way to talk about all of those things and a way that was I suppose slightly removed to start with. It's almost like a different lens or a different filter to give us a way to look at all those things, almost like a magnifying lens; you can either hold it really close to your eye and it gives you like a blurry view of the world that goes on and you can relax behind that and find a way to explore things in a funny way or an interesting way, but you can also go really close into the subject and then you've got to deal with the things that are painful and the things that are difficult and the things that have had an impact.    But, because you've got that tool and you're used to using it or you're familiar with using it, it then gives you that safety. That's how I felt about it anyway, it was a massive tool to be able to get behind all of these things that I didn't even know I was feeling, or I knew they were making me uncomfortable, but I didn't know what they were or what name to give them. So the poetry gave us a chance to get behind all of that. Having read the poems, it feels like it's that for everybody but obviously you'd have to speak to them to know, but it certainly felt like that for me.  Natalie: And, Rich, your perspective.  What are you taking forward from the project, so what would your sort of key takeaway be?  Rich: I think it shows what is possible under that PPIE acronym. And there are many ways to do that involvement and engagement, it doesn't have to be a sort of dry tick-box exercise, there are much more creative ways to bring people's lived experiences and perspectives into conversations with genomics. So really, I suppose it's a call for other people to explore working in this way as well and think about what other kind of creative outputs could work here. I mean, we've had huge success, and I think a really interesting impact from working in this way.    And certainly as an early career researcher it's been really formative in my sort of academic journey, you know, reaffirmed that this is the kind of work that I want to do, working in this really co-productive way. And I think it's possible, it can be done, and, you know, ultimately it's just been a real privilege to do this kind of research, to sort of be trusted to sort of hold a space together for sharing people's stories and give people a platform to share some really powerful profound stories. And going back to what Paul was saying earlier, I think he hit the nail on the head, as he very often does, this is about evoking people's experiences, not just explaining people's experiences, and allowing those stories to travel.  And we don't know where stories will travel, we don't know how stories will travel, we don't know how stories will be received, but we know that they do sort of travel and they do have legacy and they stay memorable to people, they have emotional resonance. So, the impact of this work can often be hard to sort of pin down really specifically, but we know those stories are out there and people are listening and changing their practice as a result.  Natalie: We'll wrap up there. I'd like to thank our guests, Paul Arvidson, Professor Bobbie Farsides and Dr Rich Gorman, for joining me today as we discuss the EPPiGen Project. We heard some powerful insights from patients and families about their experiences, and why ethical preparedness is so important in the context of genomic medicine. If you would like to hear more like this, please subscribe to Behind the Genes on your favourite podcast app. Thank you for listening. I've been your host, Natalie Banner. This podcast was edited by Bill Griffin at Ventoux Digital and produced by Naimah Callachand. 

Are we shaped by our genes or by our environment? For centuries, this question has fueled one of science's most enduring debates. But the truth is more shocking—and more fascinating—than either side ever imagined. Princeton professor Dalton Conley reveals why we need to abandon the idea of "nature vs. nurture" and embrace a radically new understanding of human development.

[This episode originally aired on May 2, 2023]  Today we are exploring four traditional methods or practices we can use to awaken our enlightened genes  •  the first method is cultivating loving kindness, or maitri, which is a key theme in the mahayana; it is connected with the wish that all beings be happy, and that includes you  •  the second method is cultivating compassion, or karuna  •  while loving kindness looks into the nature of happiness, compassion looks into the nature and causes of suffering  •  the third method is cultivating sympathetic joy — a joy based on appreciating others' happiness and accomplishments  •  the fourth method is cultivating equanimity — cultivating an even mind, a grounded mind, a magnanimous mind; we deal with each experience equally with no bias  •  these four methods — kindness, compassion, joy, and equanimity — are gentle, but they are powerful methods for awakening our enlightened genes.

Un problema habitual de los usuarios de iPhone es que las fotos que sacamos se guardan en nuestro teléfono en formato HEIC. Se trata de un formato con más calidad y mejor compresión que JPG, pero todavía a día de hoy ofrece problemas de compatibilidad con algunos sistemas.

In today's episode of The Root Cause Medicine Podcast, Dr. Lauren Hernandez and Dr. Devan Szczepanski join Dr. Kate Kresge to explore: 1. How to identify early signs of chronic illness in children 2. Why traditional pediatric testing often misses crucial health markers that could prevent chronic conditions 3. The "Triangle of Health" framework for pediatric functional medicine 4. How to use genetic testing to determine the most appropriate formula and dietary choices for infants and young children 5. Why conventional approaches to ADHD, anxiety, and digestive issues may be missing underlying genetic and metabolic factors Dr. Lauren Hernandez and Dr. Devan Szczepanski are pioneering practitioners at NuWell Medicine, where Dr. Hernandez serves as CMO of KidsWell, their specialized pediatric service line. With vast backgrounds in pediatric medicine, they have developed an innovative "triangle of health" approach that combines comprehensive blood work, metabolic, gut microbiome analysis, and genomic testing to provide personalized care for children. Their work has transformed traditional pediatric practice by incorporating functional medicine principles and precision testing to address chronic childhood conditions before they become severe health challenges. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

Host: Denise M. Dupras, M.D., Ph.D. Guest: Heidi Nelson, M.D., Emeritus Chair of the Department of Surgery and past Chair of the Division of Colon & Rectal Surgery at Mayo Clinic in Rochester Guest: Jaeyun Sung, Ph.D., Associate Professor of Biomedical Informatics and Senior Associate Consultant II in the Department of Quantitative Health Sciences, Mayo Clinic Rochester This episode of Genes & Your Health presents the results of the Gut Microbiome Wellness Index 2 study, which examines the differences between the gut microbiomes of healthy and disease-affected populations. Drs. Nelson and Sung discussed a potential future where a stool gut microbiome profile could be used as a barometer of general gut health and outlined how the microbiome can be altered and used to predict overall health.  They also covered factors that can contribute to returning the gut microbiome to healthy status after a disruption. Connect with us and learn more here: https://ce.mayo.edu/online-education/content/mayo-clinic-podcasts 

We know life on Earth wouldn't be possible without the moon. Now scientists are finding the moon might even be influencing our biology on a molecular level. Guest: Rebecca Boyle, science journalist and author of Our Moon: How Earth's celestial companion transformed the planet, guided evolution, and made us who we are For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable (and get ad-free episodes) by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

[This episode originally aired on April 25, 2023]  In this episode we will be looking at the obstacles we might encounter in trying to awaken our enlightened genes, as well as situations that support their awakening  • Trungpa Rinpoche called the first obstacle intrinsic slavery: we become slaves to our schemes, to our work, to our possessions  •  the second obstacle is being unaware: having a limited kind of awareness which does not look beyond the superficial level of things  •  the third obstacle says that enlightened genes won't awaken in the midst of evil actions or harmful behavior  •  the fourth obstacle is sleepiness, which is similar to a lack of awareness, but it also has a quality of being dull and drowsy  •  there are two conditions that are conducive to awakening enlightened genes  •  the first is waking up at the right time, which points to creating outer conditions that sustain our practice and cultivate our awakening  •  the second is taking an interest in dharma practice  •  the idea of enlightened genes is that they're there, but they don't always show themselves until the conditions are right, until obstacles are removed. 

Farah O'Regan talks about how her son who had Down syndrome and a severe congenital heart condition needing surgery diagnosed in pregnancy and then developed Type 1 diabetes on day 2 of life.  In early childhood he was diagnosed with 2 more autoimmune conditions, coeliac disease and hypothyroidism.  Researcher Matt Johnson explains his research which has established that Down syndrome directly results in very early-onset autoimmune diabetes. Send us a text

Lección 03 - Imágenes tomadas del matrimonio by La Voz de la Esperanza