Podcasts about genes

Sequence of DNA or RNA that codes for an RNA or protein product

  • 5,220PODCASTS
  • 10,358EPISODES
  • 38mAVG DURATION
  • 1DAILY NEW EPISODE
  • Aug 30, 2025LATEST
genes

POPULARITY

20172018201920202021202220232024

Categories



Best podcasts about genes

Show all podcasts related to genes

Latest podcast episodes about genes

Patronus Unplugged
NUESTRA OPINIÓN SOBRE LAS NUEVAS IMÁGENES DE LA SERIE DE HARRY POTTER - Episodio exclusivo para mecenas

Patronus Unplugged

Play Episode Listen Later Aug 30, 2025 67:54


Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! Únete a nosotros en Patronus Unplugged, tu podcast en español especializado en Harry Potter, Animales Fantásticos y todo lo relacionado con el Wizarding World de la mano de Beatriz M. Arranz, Saida Herrero y Fernando Vidal. Volvemos tras unas pequeñas vacaciones con un nuevo programa exclusivo en el que comentamos las imágenes que se han filtrado del rodaje de la nueva serie de Harry Potter para HBO Max. Únete a nuestra comunidad en el siguiente enlace: https://discord.gg/aS3UMmj8nh Cualquier comentario será bienvenido por aquí, por nuestras redes sociales (o a través del hashtag #PatronusUnplugged) y a través de nuestro correo electrónico. https://www.instagram.com/patronusunplugged/ @PatronusUnplug PatronusUnplugged@gmail.comEscucha este episodio completo y accede a todo el contenido exclusivo de Patronus Unplugged. Descubre antes que nadie los nuevos episodios, y participa en la comunidad exclusiva de oyentes en https://go.ivoox.com/sq/638268

Un Jour dans l'Histoire
L'Histoire de Gênes et les prémices du capitalisme mondial

Un Jour dans l'Histoire

Play Episode Listen Later Aug 29, 2025 40:08


Nous sommes en 1432. Alors qu'il voyage vers Bâle, l'humaniste Enea Silvio Piccolomini, futur pape Pie II, rédige une lettre dans laquelle il rapporte ses impressions sur la cité de Gênes, en Ligurie, au N-O de la péninsule italienne. Il écrit : « Le port est protégé par une jetée qui aurait coûté à peine plus si elle avait été construite en argent : la mer est d'une telle profondeur ici ! C'est un refuge sûr pour les bateaux qui viennent toujours mouiller en grand nombre. Ils viennent et repartent rapidement (…), certains de l'Est et d'autres de l'Ouest, de telle sorte que chaque jour l'on peut observer des hommes de différentes races, d'étranges et de rudes coutumes, mais aussi des marchands qui arrivent porteurs de toutes sortes de richesses. Bien plus, dans le quartier du port qui le raccorde à la ville, il y a de superbes palais en marbre qui touchent le ciel, extrêmement élégants et pourvus de nombreuses colonnes, dont beaucoup sont ornés de sculptures et de statues. À leur pied court un portique d'environ mille pieds de long où l'on peut acheter n'importe quelle sorte de marchandise. Le reste de la cité s'étend vers les collines : les grandes et belles maisons y sont si élégantes et somptueusement décorées qu'aucune d'entre elles ne disconviendrait à un roi ou à un prince : en effet, toutes ont une majesté régalienne, extrêmement grandes, et proches les unes des autres. », conclut le pas encore souverain pontife (il lui faudra attendre une vingtaine d'années). Quoiqu'il en soit, son éloge ne doit pas nous faire oublier qu'au XVe siècle Gênes se déchire dans de nombreuses guerres civiles. Ce qui n'empêchera pas le siècle suivant d'être son âge d'or : elle devient une pièce maîtresse de la puissance des Habsbourg et souffle les prémices d'un capitalisme mondial. Avec nous : Fabien Levy, docteur en histoire médiévale. « Histoire de Gênes – Le souffle du capitalisme mondial » ; Passés/Composés Sujets traités : Gênes, prémices, capitalisme, mondial, Enea Silvio Piccolomini, Pie II, Merci pour votre écoute Un Jour dans l'Histoire, c'est également en direct tous les jours de la semaine de 13h15 à 14h30 sur www.rtbf.be/lapremiere Retrouvez tous les épisodes d'Un Jour dans l'Histoire sur notre plateforme Auvio.be :https://auvio.rtbf.be/emission/5936 Intéressés par l'histoire ? Vous pourriez également aimer nos autres podcasts : L'Histoire Continue: https://audmns.com/kSbpELwL'heure H : https://audmns.com/YagLLiKEt sa version à écouter en famille : La Mini Heure H https://audmns.com/YagLLiKAinsi que nos séries historiques :Chili, le Pays de mes Histoires : https://audmns.com/XHbnevhD-Day : https://audmns.com/JWRdPYIJoséphine Baker : https://audmns.com/wCfhoEwLa folle histoire de l'aviation : https://audmns.com/xAWjyWCLes Jeux Olympiques, l'étonnant miroir de notre Histoire : https://audmns.com/ZEIihzZMarguerite, la Voix d'une Résistante : https://audmns.com/zFDehnENapoléon, le crépuscule de l'Aigle : https://audmns.com/DcdnIUnUn Jour dans le Sport : https://audmns.com/xXlkHMHSous le sable des Pyramides : https://audmns.com/rXfVppvN'oubliez pas de vous y abonner pour ne rien manquer.Et si vous avez apprécié ce podcast, n'hésitez pas à nous donner des étoiles ou des commentaires, cela nous aide à le faire connaître plus largement. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Nassau Morning Madhouse
CONSPIRACY CHAT SYDNEY'S GENES??

Nassau Morning Madhouse

Play Episode Listen Later Aug 28, 2025 8:46


Sydney Sweeney gets exposed for having great GENES??? The monday crew gets into the whole controversay or should I say conspiracy !

ABC Cardinal 730AM
28 08 2025 01 Momento Justo móvil Claudio Genes Audio Abc tv

ABC Cardinal 730AM

Play Episode Listen Later Aug 28, 2025 0:37


28 08 2025 01 Momento Justo móvil Claudio Genes Audio Abc tv by ABC Color

SBS Spanish - SBS en español
Understand Aboriginal land rights in Australia - Comprender los derechos territoriales aborígenes en Australia

SBS Spanish - SBS en español

Play Episode Listen Later Aug 27, 2025 10:05


You may hear the protest chant, “what do we want? Land rights!” —but what does it really mean? Land is at the heart of Aboriginal and Torres Strait Islander identity, culture, and wellbeing. Known as “Country,” it includes land, waterways, skies, and all living things. In this episode of Australia Explained, we explore Indigenous land rights—what they involve, which land is covered, who can make claims, and the impact on First Nations communities. - Puede que escuches el lema de protesta: "¿Qué queremos? ¡Derechos sobre la tierra!" —pero, ¿qué significa realmente? La tierra está en el corazón de la identidad, cultura y bienestar de los aborígenes y de los isleños del Estrecho de Torres. Lo que ellos conocen como "país," incluye la tierra, las vías fluviales, el cielo y todos los seres vivos. En este episodio de Australia Explained, exploramos los derechos sobre la tierra indígena —qué abarcan, qué tierras están consideradas, quién puede hacer reclamaciones y el impacto de esto en las comunidades de las Primeras Naciones.

The G Word
Francisco Azuaje, Karim Beguir, Harry Farmer and Dr Rich Scott: How can cross-sector collaborations drive responsible use of AI for genomic innovation?

The G Word

Play Episode Listen Later Aug 27, 2025 38:08


In this episode of Behind the Genes, we explore how Artificial Intelligence (AI) is being applied in genomics through cross-sector collaborations. Genomics England and InstaDeep are working together on AI and machine learning-related projects to accelerate cancer research and drive more personalised healthcare. Alongside these scientific advances, our guests also discuss the ethical, societal and policy challenges associated with the use of AI in genomics, including data privacy and genomic discrimination. Our guests ask what responsible deployment of AI in healthcare should look like and how the UK can lead by example. Our host, Francisco Azuaje, Director of Bioinformatics Genomics England is joined by Dr Rich Scott, Chief Executive Officer at Genomics England Karim Beguir - Chief Executive Officer at InstaDeep Harry Farmer – Senior Researcher at Ada Lovelace Institute If you enjoyed today's conversation, please like and share wherever you listen to your podcasts. And for more on AI in genomics, tune in to our earlier episode: Can Artificial Intelligence Accelerate the Impact of Genomics? "In terms of what AI's actually doing and what it's bringing, it's really just making possible things that we've been trying to do in genomics for some time, making these things easier and cheaper and in some cases viable. So really it's best to see it as an accelerant for genomic science; it doesn't present any brand-new ethical problems, instead what it's doing is taking some fairly old ethical challenges and making these things far more urgent."   You can download the transcript, or read it below.   Francisco: Welcome to Behind the Genes. [Music plays] Rich: The key is to deliver what we see at the heart of our mission which is bringing the potential of genomic healthcare to everyone.  We can only do that by working in partnership.  We bring our expertise and those unique capabilities.  It's about finding it in different ways, in different collaborations, that multiplier effect, and it's really exciting.  And I think the phase we're in at the moment in terms of the use of AI in genomics is we're still really early in that learning curve. [Music plays] Francisco: My name is Francisco Azuaje, and I am Director of Bioinformatics at Genomics England.  On today's episode I am joined by Karim Beguir, CEO of InstaDeep, a pioneering AI company, Harry Farmer, Senior Researcher at the Ada Lovelace Institute, and Rich Scott, CEO of Genomics England.  Today we will explore how Genomics England is collaborating with InstaDeep to harness the power of AI in genomic research.  We will also dive into the critical role of ethical considerations in the development and application of AI technologies for healthcare.  If you've enjoyed today's episode, please like, share on wherever you listen to your podcasts. [Music plays] Let's meet our guests. Karim: Hi Francisco, it's a pleasure to be here.  I am the Co-Founder and CEO of InstaDeep and the AI arm of BioNTech Group, and I'm also an AI Researcher. Harry: I'm Harry Farmer, I'm a Senior Researcher at the Ada Lovelace Institute, which is a think-tank that works on the ethical and the societal implications of AI, data and other emerging digital technologies, and it's a pleasure to be here. Rich: Hi, it's great to be here with such a great panel.  I'm Rich Scott, I'm the CEO of Genomics England. Francisco: Thank you all for joining us.  I am excited to explore this intersection of AI and genomics with all of you.  To our listeners, if you wish to hear more about AI in genomics, listen to our previous podcast episode, ‘Can Artificial Intelligence Accelerate the Impact of Genomics', which is linked in this podcast description. Let's set the stage with what is happening right now, Rich, there have been lots of exciting advances in AI and biomedical research but in genomics it's far more than just hype, can you walk us through some examples of how AI is actually impacting genomic healthcare research? Rich: Yeah, so, as you say, Francisco, it is a lot more than hype and it's really exciting.  I'd also say that we're just at the beginning of a real wave of change that's coming.  So while AI is already happening today and driving our thinking, really we're at the beginning of a process.  So when you think about how genomics could impact healthcare and people's health in general, what we're thinking about is genomics potentially playing a routine part in up to half of all healthcare encounters, we think, based on the sorts of differences it could make in different parts of our lives and our health journey.  There are so many different areas where AI, we expect, will help us on that journey.  So thinking about, for example, how we speed up the interpretation of genetic information through to its use and the simple presentation of how to use that in life, in routine healthcare, through to discovery of new biomarkers or classification that might help us identify the best treatment for people.  Where it's making a difference already today is actually all of those different points.  So, for example, there's some really exciting work we're doing jointly with Karim and team looking at how we might use classification of the DNA sequence of tumours to help identify what type of tumour - a tumour that we don't know where it's come from, so what we call a ‘cancer of unknown primary' - to help in that classification process.  We're also working with various different people who are interested in classification for treatment and trials, but there's also lots in between recognising patterns of genomic data together with other complex data.  So we've been doing a lot of work bringing image data together with genomic data and other health data so that you can begin to recognise patterns that we couldn't even dream of.  Doing that hand in hand with thinking about what patients and participants want and expect, how their data is used and how their information is held, bringing it all together and understanding how this works, the evidence that we need before we can decide that a particular approach is one that policymakers, people in healthcare want to use, is all part of the conversation. Francisco: Thank you, Rich, for speaking of cutting-edge AI applications and InstaDeep.  Karim, could you give us a glimpse into your work and particularly how your technologies are tackling some of the biggest challenges in genomic research? Karim: Absolutely, and I think what's exciting is we've heard from Rich and, you know, this is like the genomics expertise angle of things and I come from the AI world and so do most of the InstaDeep team.  And really what's fascinating is this intersection that is being extremely productive at the moment where technologies that have been developed for like multiple AI applications turn out to be extremely useful in understanding genomic sequences.  This is a little bit, our journey, Francisco.  Back in 2021/2022 we started working on the very intriguing question at the time of could we actually understand better genomic sequences with the emerging technologies of NLP, natural language processing.  And you have to put this in context, this was before even the word ‘generative AI' was coined, this was before ChatGPT, but we had sort of like an intuition that there was a lot of value in deploying this technology.  And so my team, sort of like a team of passionate experts in research and engineering of AI, we tackled this problem and started working on it and the result of this work was our nucleotide transformer model which we have open sourced today; it's one of the most downloaded, most popular models in genomics.  And what's interesting is we observed that simply using the technologies of what we call ‘self-supervised learning' or ‘unsupervised learning' could actually help us unlock a lot of patterns. As we know, most of genomics information is poorly understood and this is a way actually, with using the AI tool, to get some sense of the structure that's there. So how do we do this?  We basically mask a few aspects of the sequence and we ask the system to figure them out.  And so this is exactly how you teach a system to learn English, you know, you are teaching it to understand the language of genomics, and, incredibly, this approach when done at scale - and we train a lot on the NVIDIA Cambridge-1 supercomputer – allows you to have results and performances that are matching multiple specialised models.  So until then genomics and use of machine learning for genomics was for a particular task, I would have developed a specific model using mostly supervised learning, which is, I am showing you a few examples, and then channelled these examples and tried to match that, and so essentially you had one model per task.  What's really revolutionary in this new paradigm of AI is that you have a single model trained at very largescale, the AI starts to understand the patterns, and this means that very concretely we can work with our partners to uncover fascinating relationships that were previously poorly understood.  And so there is a wealth of potential that we are exploring together and it's a very exciting time. Francisco: What you're describing really highlights both the potential and the opportunities but also the responsibility we have with these powerful tools, its power, and this brings up some important ethical considerations.  And we have Harry…  Harry, we have talked about ethics frameworks in research for decades but AI seems to be rewriting the rulebook.  For your work at the Ada Lovelace Institute what makes AI fundamentally different from previous technologies when it comes to ethical considerations and how does this reshape our approach to ensuring these powerful tools benefit society as a whole? Harry: So I think when you are considering these sorts of ethical questions and these sorts of ethical challenges posed by AI and genomics it really depends on the sort of deployment that you're looking at.  From the conversation we've had so far, I think what's been hinted at is some of the diversity of applications that you might be using AI for within the context of genomics and healthcare.  So I think there's obviously big advances that have been alluded to in things like drug discovery, in things like cancer and cancer diagnosis, also these advances around gene editing, all of which have been on steroids, by artificial intelligence and particularly machine learning and deep learning. The area that we have been looking at at the Ada Lovelace Institute, and this was a project that we were doing in collaboration with the NCOB, the Nuffield Council on Bioethics, was looking at what we were calling ‘AI-powered genomic health prediction', which is very related to a technique called ‘polygenic scoring', for those who might be interested.  And that's looking at the emerging ability to make predictions about people's future health on the basis of their DNA, and it was thinking about what that ability might mean for UK society and also for how we are thinking about and delivering healthcare in the UK. Now, thinking about what the ethical challenges might be for that, I think you need to think about what specifically AI is bringing to that technique, so what it's bringing to genomic health prediction.  I think with some of the other deployments, the list of things that AI is bringing is quite similar, so it's helping with data collection and processing, so speeding up and automating data collection and preparation processes that otherwise are quite slow and very labour-intensive.  AI's also helping with the analysis of genomic and phenotype data, so helping us to understand the associations between different genomic variations and between observable traits, and this is something which without AI can often be prohibitively complex to do, and it's also sometimes suggested that on the deployment end AI can be a tool that can help us use genomic insight in healthcare more widely.  So one example of this might be using an AI chat bot to explain to a patient the results of a genomic test.  That's something that's only been mooted and I don't think there are current examples of that at the moment but that's one of the downstream applications of AI in the context of genomics. So in terms of what AI's actually doing and what it's bringing, it's really just making possible things that we've been trying to do in genomics for some time, making these things easier and cheaper and in some cases viable.  So really it's best to see it as an accelerant for genomic science; it doesn't present any brand-new ethical problems, instead what it's doing is taking some fairly old ethical challenges and making these things far more urgent.  So in terms of what those problems actually are, some of the big ones will be around privacy and surveillance, genomic health predictions produce a lot of intimate sensitive data about people and generating those insights requires the collection and the storage and the processing of a lot of very sensitive data as well.  We also have issues related to privacy around genomic discrimination, so this is the worry that people will be treated differently and in some cases unfairly on the basis of health predictions made about them.  And one of the really typical examples here is the worry that people might face higher insurance costs if they're found through genomic testing to be more likely to develop particular diseases over their life course. And then you also have a bunch of issues and questions which are more structural, so these are questions about how the availability of this kind of insight into people's future health might change or put pressure on existing ways of thinking about health and thinking about healthcare and some extreme cases thinking about the social contract.  So these are questions like does the viability of genomic health prediction lead to a radically more preventative approach to healthcare and what might this mean for what the state demands of you as a user of healthcare and as a recipient of that.  And there are also some important questions about the practicalities of delivering genomic medicine in the NHS, so questions like how does the NHS retain control and sovereignty over genomic analysis and data capacities, how do we test their efficacy at a public health level, and also – and this is something that we might talk about a bit later – what's the best deployment model for these capacities.  So that's some of the ethical and I think policy challenges that we need to be dealing with in this space. Francisco: Thank you, Harry.  And those principles you have outlined provide a solid foundation for discussing different types of applications. [Music plays] Let's talk about the InstaDeep and Genomics England partnership that is investigating the application of InstaDeep's powerful foundation model, the nucleotide transformer, and other cutting edge techniques to address several challenges in cancer research.  I have the privilege of working closely with this partnership and the potential here is immense.  Karim, could you break down for our listeners what you are working on together and what innovations you are aiming for? Karim: Absolutely, Francisco.  Actually, we are very excited by the collaboration with Genomics England.  Genomics England not only has one of the best data assets in the world when it comes to genomics, like a very well curated dataset but also a wealth of expertise on these topics, and on my side the InstaDeep team brings fundamental knowhow of machine learning models but also, as you mentioned, like powerful developed models already, such as our nucleotide transformer and others.  The culture of InstaDeep has always been to build AI that benefits everyone – this is literally in our mission – and so in particular, specifically on like current topics, really like the goal is to try to identify partners between genomic sequences of patients and the particular phenotypes or approaches.  And one of the key projects, which I mentioned that, is the one of cancer of unknown primary origin.  So when you have situations where you are not sure where a particular cancer emerged from it is critical to be able to extract this information to have the best potential care, and this is actually something where understanding of genomic sequences can bring this capability.  And so we've been getting some successful results in the collaboration but in many ways this is just the beginning.  What we are seeing is a great wealth of possibilities linking genotypes, so the information which is on the sequences themselves, the genomic sequences, and phenotypes, like the particular state of the patient, and the fact that the Genomics England team has those joint datasets creates incredible opportunities.  So we are looking at this really like identifying together what are the most useful ‘low-hanging fruits', if you want, in terms of like potentially improving a patient's care and moving forward from that. Francisco: And this collaborative approach you are describing raises questions about accelerating innovation in general.  When two organisations like Genomics England and InstaDeep come together it's like a multiplier effect in terms of expertise, data, and other resources.  Could you both share how this partnership is accelerating discoveries that might have taken years? Rich: Yeah, I mean, I think this…  Francisco, you frame it really nicely because this is what makes it so exciting to be in our position at Genomics England because what we do is we bring the particular understanding and expertise, digital infrastructure and custodianship of the National Genomic Research Library together, but actually the key is bringing the potential of genomic healthcare to everyone.  We can only do that by working in partnership, we bring our expertise and those capabilities.  And, as you say, it's about finding it in different ways, in different collaborations, that multiplier effect, and it's really exciting.  And I think the phase we're in at the moment in terms of the use of AI in genomics is we're still really early in that learning curve.  And so, as you've heard already through what Karim and I have said and also what Harry has said, there are multiple different aspects that we need to look at together, bringing different angles and understandings, and we see ourselves…  We often describe ourselves as a ‘data and evidence engine', that final word ‘evidence' is really important and it comes in the round.  So Harry really eloquently talked about a number of different considerations from an ethical perspective that need to be there.  What we need if we're going to move genomics forwards in terms of its potential to make a difference for people's lives, we need evidence around clinical efficacy of different approaches, that's absolutely a given and everyone always jumps at…  so it's almost first in line.  We need understanding about the health economics, you know, how much difference does it make for a particular investment, is it worth that investment.  Critically, it also is founded on, you know, how you might use this technology in different ways, how you use it in clinical pathways, you know, is it something that actually is addressing the particular questions which really hold back the delivery of better care.  Also in that evidence piece is an understanding of patients' and participants' expectations on how their data might be used, their expectations on privacy, the expectations that we have on understanding how equitable the use of a particular approach might be, or at least our understanding of how confident we are about the equity of the impact, and it's bringing together those different perspectives.  And that's one of the things that helps us construct the team at Genomics England so we have the expertise to help others access the data in the National Genomic Research Library for purposes our participants support but also help generate that sort of rounded package of evidence that will end up moving the dial.  So that it's not just about proving a cool widget, because that's great on its own, what drives Karim and the team is to make a difference in terms of outcomes, and that's exactly what drives us and our participants too. Francisco: And this and other partnership approaches brings up important questions about responsible innovation, and this naturally leads us to the next question for Harry, how do we harness these powerful tools when protecting our communities? Harry: Yeah, so if we are thinking about over-surveillance and the ways that vulnerable groups might be affected by the use of genomics and healthcare, I think we're talking about at least two different things here.  So one problems around the representativeness of data is it does lead to issues which you could classify as issues of differential accuracy.  So in the context of genomic prediction what you have is genomic predictive tools being more accurate for white Europeans and those with white European ancestry compared to other population groups.  And this is a product of the fact that genomic datasets and genomic predictions, the terminologies don't port well between different populations, which means if you train a genomic predictive tool on a bunch of people with white European ancestry the predictions you might make using that tool for other groups won't be as accurate as for the white Europeans.  And this can be actively harmful and dangerous for those in underrepresented groups because you are making predictions about people which just won't have the accuracy that you would expect in the context that you were deploying it. And I already mentioned this a bit in my previous answer, you have worries about discrimination, and there are a few different things here.  So with some historically marginalised groups and marginalised groups now there are longstanding historical sensitivities about being experimented on, about particular fears about eugenics and about being categorised in particular ways.  And it's worth saying here that there is obviously a racial dimension to this worry but I think there's also a class dimension, by which I mean you're far more vulnerable to being categorised unfavourably if you're poor or if you don't have a particular kind of status within society.  There is also within discrimination the idea that genomics might be used to explain away differences between different groups which in fact have a political or an economic basis.  So one example of this was during the COVID-19 pandemic, there were attempts by some commentators to explain away the fact that non-white communities had worse rates of mortality from COVID to try and attribute a genetic or a genomic basis to those differences rather than looking at some of the socioeconomic factors behind that.  So those are some worries as well. Now, when it comes to protecting particular groups I think there are a few things that can be done fairly straightforwardly.  So, one is work to improve the diversity and the representativeness of datasets.  Obviously, that's easier said than done, though it's a very clear thing that we can aspire towards and there is good work, I'm aware, that is going on in this space, some of which is being spearheaded by Genomics England, amongst other groups.  Another is just being very careful about how the results of population level genomic studies are communicated to avoid giving that impression of explaining away differences between different groups simply as things determined by genomics about which we can do nothing rather than things which have historical or socioeconomic bases.  But I also think the broader lesson is that some of these harms and these forms of discrimination are things that could theoretically affect anyone; they're not just limited to affecting marginalised groups. Genomic health predicting can produce bases for all of us to be discriminated against, things that have nothing to do with our race, our class, our sex or any other protected characteristic.  So I think there has to be thinking about how we establish or sure up more universal protections against genomic discrimination.  One thing that we can do here is simply stronger data protection law, and one of the things that we talk about in some of our reports is that how data protection law as it stands could do with being less ambiguous when it comes to how it treats genomic data and phenotype data produced as a result of genomic analysis. [Music plays] Francisco: Harry, you are in a unique position at the Ada Lovelace Institute where you bridge this gap between AI developers, researchers, policymakers and the public.  Your recent report on AI in genomics with the Nuffield Council on Bioethics offers an important blueprint for responsible AI innovation in general, so based on this cross-sector perspective, what guiding principles do we need to embrace as we navigate this intersection of AI and genomics? Harry: So I think in addition to the specific recommendations we set out in the final report of that work - which is called ‘Predicting the Future of Health' and which you can find on our website and also on the NCOB website – I think one of the biggest messages was the importance of finding a deployment model for genomic health prediction that respects that technology's strengths, what it can actually do, because there are limitations to this technology, and also which avoids circumstances in which the associated risks are difficult to deal with.  So another way of putting this is that we need a deployment model that, as well as making sure that we're ready to cope with the risks of genomic health prediction, the things like law, regulation and governance also proactively tries to design out some of those risks and finds ways of deploying this technology such that those risks don't present themselves in either as extreme a manner or don't present themselves in ways which makes them difficult to deal with. So one question that we posed in our research was whether some ways of integrating genomic health prediction may present more challenges regarding privacy, discrimination and then these other challenges that we'd identified around dependency and fragility and others. And having looked at some of the different broad approaches to using genomic health prediction within the NHS and within the UK's health system, we found that one presented by far fewest of the risks identified above, while still presenting some of the most certain benefits of genomic health prediction.  And this was using it really primarily as a targeted diagnostic tool - and this is a vision in which the NHS uses genomic health prediction quite sparingly in the first instance - and in situations to improve treatment and outcomes for those who are seriously ill or who have been identified as needing to take particular precautions regarding their health.  We think the more situational vision has a few advantages.  So one, is it allows patient and people using the health service to retain greater control over data.  We think that can also have a positive knock-on effect for worries about discrimination.  And here what you have is the absence of those pressures to share your data.  It means that it's easier for you as the user of the healthcare system to resist genomic discrimination simply by keeping your data private.  And there are some cases where that option… it shouldn't be the only option but where that option is really important. And then also one of the features of this vision is that the smaller scale of the use of genomic health prediction, presumed, can make outsourcing to third parties, which the NHS is probably likely to need to do in some cases.  It's also a vision, I think, that overall allows you to capture some of the more certain benefits to genomic health prediction which are about improvements to accuracy in predictions about people's future health at the margin, and therefore this is a deployment of this technology which is deploying it principally to people who will benefit and we know will benefit from marginal improvements in accuracy to predictions made about their future health rather than wanting to deploy those marginal improvements to the vast majority of the population where the benefit is less certain.  So this is a vision we hope sets out a way of getting some of the more certain benefits of this technology while minimising some of those broader more systemic risks. Francisco: Thank you, Harry.  Karim? Karim: Totally agree with Harry about the need for smart regulation in the field so that we make sure we have good uses of the technology but avoid the potential pitfalls.  I wanted to emphasise two points which I believe are important.  First, we are really in a fast-moving situation when we look at like AI progress.  We have seen incredible improvements over the last ten years and in particular what we call ‘artificial general intelligence', which is essentially systems that are matching human cognitive abilities, are now around the corner.  This might sound surprising but literally the last obstacles to reach AGI are being solved right now, and this means that in the next 12-24 months you will have systems that are incredibly capable.  So this emphasises the need for the type of measures and type of smart approach that Harry has described.  And I would say when you look at the intersection of AI and genomics this is a particularly important one and why it's the case, because so far in genomics our obstacle has not been data, it has been interpretation of a flood of data.  The progress that AI is making, like I just described now, means that very soon extraordinary capabilities will be available to improve patients' outcomes.  I want to inject a sense of how important is our conversation today, given what is happening, an exponential progress in AI, exponentially growing data in genomics and relatively exponential potential to build the technology for good.  But, like in other fields, we see that AI is an extremely powerful technology and we need to make sure it is used for good in fact and this is why the conversation that we have today is so important. Harry: Obviously I agree with the conclusion to all of this, is that we need to think very hard about the way that artificial intelligence and its deployment in healthcare and also just in many different walks of life is going to be affecting the way we think about public service delivery, affecting the way that we think about scientific development.  It's worth noting, though, that I think one of the biggest challenges from a policy perspective on artificial intelligence is being able to distinguish the wheat from the chaff.  There are obviously areas where AI has made huge and incredibly impressive progress over the past few years and where we reasonably expect that to continue over the next few years, but there are also areas where some of the stories being told about the capabilities of future systems probably won't be matched by the reality, but there is I think a really big and very live debate about exactly what we can reasonably expect from these technologies and therefore what the deployments of them are. Francisco: Thank you.  We are approaching the end of the episode and I'd like to conclude with a couple of questions.  Genomics England has built quite an ecosystem of industry partnerships, how do collaborations like the one with InstaDeep fit into your broader mission for the company? Rich: So linking this to the conversation that we've just been having, which is AI is making a real difference in terms of technologies that we can test, we can develop evidence on, and that is rightly creating excitement, I think our approach…  The expectation of our participants is that our role is to sit there and help people develop evidence and you can make judgments on policy based on those and that is what will drive adoption.  I think the thing that really excites me for the UK, most particularly in genomics, is our ability to be the place in the world where you can come with a new technology, whether it's genomic sequencing technology, whether it's a genomic AI approach to train that to develop evidence on its efficacy, and, if it's proven to be effective to be worth the bang for the buck to perform to the expectations that patients, the public, would have of it in terms of equity and so forth also to deploy it.  I think there is a real reason for excitement around that and it's a real opportunity that the government has highlighted and that we absolutely buy into that the UK can be the best place to do that for academics and for industry.  And our participants see real opportunity and are eager for that work to be done so that we have the evidence on which to decide what should be deployed and where.  We see opportunities in all sorts of different areas, so certainly in terms of drug discovery and all the way through to simplifying tasks which at the moment just limit the rate at which the existing uses of genomics in healthcare can happen. So I think there's opportunities across the whole length, if you like, the sort of end to end, and the breadth of opportunity, and industry, companies like InstaDeep and others that we work with, are really crucial to that.  And what we do is think about the digital infrastructure we need to, you know, have those teams able to interact with within the National Genomic Research Library carrying out their approved research projects.  Also what support they need, and that comes in different shapes and sizes, depending on the ask and also the company.  So sometimes sort of leaning in more, particularly at the start of programmes, to help people shape the question, working with our participants, thinking about the wider evidence that you might need, for example, those sort of things that Harry's touched on, but also thinking about what hands-on support companies need, because not every company is anywhere close to Karim and InstaDeep's expertise.  Sometimes this is also about supporting people to have some of those tools that they don't have or some of the knowhow that's very specific to areas of genomics, so it's absolutely crucial to it.  And I think that point of the UK being the place to come and develop that evidence in its full breadth so that policy decisions can be made not based on hype but on evidence in the round, on what will make a difference. Francisco: And, Karim, looking ahead, also in retrospect, what have been your key learnings about making this cross-sector partnership work? Karim: We live in an extraordinary time and I want to emphasise the potential of scientific discovery in the next two or three years.  AI is going to move from, let's say, digital style, you know, technologies like coding and maths towards more like science and biology.  In particular, genomics is going to be a fascinating area in terms of potential, and I agree with Rich and Harry, it's all in the end about proving on the ground the potential of those capabilities.  And at InstaDeep we are passionate about the tech – I think you might have felt that – but we're also passionate about the applications.  The best results come when you bring expertise from multiple domains; machine learning and AI experts will require the expertise of genomic experts, biologists, healthcare practitioners, to be able to translate the potential of those technologies in concrete outcomes.  And we've seen this on multiple successful projects we've done with Genomics England but really this suggests that we are going to have in the next 3-5 years way more progress than we had in the last five and really my wish is that collectively we seize this opportunity and we do it in a responsible and thoughtful manner. [Music plays] Francisco: We'll wrap up there.  Thank you to our guests, Karim Beguir, Harry Farmer and Rich Scott, for joining me today as we discuss the role of AI in genomics research.  If you wish to hear more like this, please subscribe to Behind the Genes on your favourite podcast app.  Thank you for listening.  I have been your host, Francisco Azuaje.  This podcast was edited by Bill Griffin at Ventoux Digital and produced by Naimah Callachand. [Music plays]    

Parsha Podcast - By Rabbi Yaakov Wolbe
Shoftim – Crisper Genes (5783)

Parsha Podcast - By Rabbi Yaakov Wolbe

Play Episode Listen Later Aug 26, 2025 49:20


The nation is on the doorstep of Canaan. In our Parsha, the people are instructed in how they must treat the Canaanite inhabitants of the land. It's not pleasant. The people are told that they must engage in total war against these nations. How do we understand the requirement to be so violent and aggressive […]

All Rabbi Yaakov Wolbe Podcasts
Parsha: Shoftim - Crisper Genes (5783)

All Rabbi Yaakov Wolbe Podcasts

Play Episode Listen Later Aug 26, 2025 49:20


The nation is on the doorstep of Canaan. In our Parsha, the people are instructed in how they must treat the Canaanite inhabitants of the land. It's not pleasant. The people are told that they must engage in total war against these nations. How do we understand the requirement to be so violent and aggressive towards the Canaanite nations? What about the Canaanites who opt to join the nation? What is their status? In this podcast, we first explore the general notion of how to understand the Torah's instructions regarding the Canaanite policy, and then we explore a very interesting thread about the power of behavior and how it can get embedded in the spiritual DNA that we transmit to our descendants.– – – – – – – – – – – – – – – – – – – – – –DONATE: Please consider supporting the podcasts by making a donation to help fund our Jewish outreach and educational efforts at https://www.torchweb.org/support.php. Thank you!– – – – – – – – – – – – – – – – – – – – – –Email me with questions, comments, and feedback: rabbiwolbe@gmail.com– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to my Newsletterrabbiwolbe.com/newsletter– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to Rabbi Yaakov Wolbe's PodcastsThe Parsha PodcastThe Jewish History PodcastThe Mitzvah Podcast This Jewish LifeThe Ethics PodcastTORAH 101 ★ Support this podcast ★

Hoy por Hoy
Las crónicas de Sastre | Israel no quiere imágenes que documenten matanzas a las que Netanyahu llama accidentes y que en realidad revelan crímenes de guerra y un genocidio

Hoy por Hoy

Play Episode Listen Later Aug 26, 2025 2:27


Hubo primero un ataque contra el hospital Nasser en Gaza. Empezaron a llegar los servicios de rescate. Los periodistas, para contarlo. Por eso esta vez hay vídeo. Estaban tomando imágenes. Se ve -se les ve a lo lejos- a personas con chalecos naranjas. Con guantes. Se ve cómo se organizan para tratar de sacar a los heridos. Fue un ataque contra los periodistas. Ayer el ejército israelí mató a cinco. A cinco en un hospital. Luego, mataron a otro de un disparo en Al Mawasi. Netanyahu ha dicho que valora el trabajo de los periodistas y que el bombardeo al hospital fue un accidente. De momento han matado a más de 240 periodistas según las autoridades gazatíes. Se llamaban Hossam Al Masri, Mohamed Salama, Mariam Abu Daqqa, Moaz Abu y Ahmed Abu Aziz. 

SBS Spanish - SBS en español
Se cumple medio siglo desde la devolución de tierras a los gurindji: un hito para los aborígenes en Australia

SBS Spanish - SBS en español

Play Episode Listen Later Aug 25, 2025 9:32


Tras casi una década de lucha, en 1975, el entonces primer ministro australiano Gough Whitlam le otorgó al pueblo gurindji el arrendamiento de una parcela de tierra en la estación ganadera de Wave Hill, en el Territorio del Norte.

Podcast Archives - Jay Garvens
WHY IS DENVER DESTROYING OUR GENES – 08-16-25

Podcast Archives - Jay Garvens

Play Episode Listen Later Aug 25, 2025 37:28


Listen to Jay Garvens Home & Mortgage Show at 8am.  This show he talks about how Denver is taking Colorado’s genes away from them! On KRDO New Radio 105.5FM & 1240AM Saturdays and 11am on... The post WHY IS DENVER DESTROYING OUR GENES – 08-16-25 appeared first on Jay Garvens.

Wits & Weights: Strength and Nutrition for Skeptics
Can Your DNA Predict How Fast You'll Build Muscle and Lose Fat? (Joe Cohen) | Ep 364

Wits & Weights: Strength and Nutrition for Skeptics

Play Episode Listen Later Aug 22, 2025 49:38 Transcription Available


Join Physique University (free for 2 weeks) to engineer your best physique using our science-based fat loss and muscle-building blueprint—Why can two people follow the same diet and training plan but get completely different results? Could your DNA explain why fat loss feels harder, or why recovery takes longer? And is genetic testing the breakthrough it claims to be or just another fitness gimmick?With me is Joe Cohen, founder and CEO of SelfDecode, to separate the science from the scams. Joe shares what your genes can actually tell you about building muscle, losing fat, and preventing disease, and where the industry is misleading you. We also dig into how combining genetic data with lab work creates actionable steps you can measure and adjust over time.Tune in to discover whether your DNA could be the missing piece in your fitness journey.Today, you'll learn all about:0:00 – Intro2:17 – Why most DNA health tests fail6:44 – Marketing hype vs real science9:59 – Moving beyond the fitness basics12:01 – Diseases genetics can predict well16:38 – Universal habits vs targeted actions18:15 – How SelfDecode prioritizes recommendations22:43 – Genes and training insights27:22 – Pathways and functional genetics31:17 – Combining genetics with lab work38:07 – Joe's story of food intolerance45:45 – Where to learn more about SelfDecodeEpisode resources:Website: SelfDecode.comInstagram: @mrbiohacker Facebook: @selfdecode X: @SelfDecode Support the show

Atypical Talk
Jeans, Genes, and Zoo Requests

Atypical Talk

Play Episode Listen Later Aug 21, 2025 31:07


This week, we talk about the American Eagle ad that has caused a lot of backlash. We also talk about a zoo in Denmark with an unusual request. And we talk about how some churches have made authenticity an "idol". Watch this episode now or listen on any podcast platform! Sydney Sweeney Fronts Ad Campaign for Jeans—Sparks Debate About Eugenicshttps://www.newsweek.com/sydney-sweeney-american-eagle-ad-controversy-2105004Denmark zoo asks people to donate unwanted pets to feed predators and imitate ‘natural food chain'https://www.cnn.com/2025/08/04/europe/denmark-aalborg-zoo-pets-predators-intl-hnkHave We Made ‘Authenticity' an Idol?https://relevantmagazine.com/faith/have-we-made-authenticity-idol/

X-Men Horoscopes
Alicia and Justin Wilder: Cassandra Nova is a Vengeful Sack of Genes - X-Men Red 6

X-Men Horoscopes

Play Episode Listen Later Aug 21, 2025 73:45


Welcome true believers to X-Men Horoscopes where each week our host Lodro Rinzler is in conversation with a special guest to discuss the X-Men issue that aligns with a significant month and year from their life and what that issue reveals about their future. With us today are the co-hosts of The X-Wife Podcast, Alicia and Justin Wilder. We dive into their wedding anniversary issue - a heist issue known as X-Men Red 6 - as well as how they got together, and even see how they rate as a couple with our brand-new segment: the X-Newlywed Games! Also in this episode: the new revamp of the X-Wife Podcast - it's bi now! Everything is Magik a deep dive on everyone's favorite X-Man: Gentle Abslantis Searebro How your brain waves can totally ride the ocean waves All this plus we spend way too long arguing about both Inferno and Wolverine. What does any of this mean for their future as a couple? Tune in to find out! Alicia Wilder is a multifaceted performer based in Rhode Island. She graduated from Rhode Island College with a BA in Dance and minors in Theatre & Film. Alicia is the founder and Artistic Director/Choreographer of Metamorphosis: the TEN31 Dance Company and works as a Living Art & Character performer with TEN31 Productions.  She has been performing and producing shows professionally for over 14 years. Alicia is also a lifelong nerd, avid cosplayer and is the Co-Host of The X-Wife Podcast. Her passion for costume making combined with her love for nerd culture has launched her headfirst into the world of conventions, cosplay and nerd events. Justin Wilder is a digital content creator and co-host of The X-Wife Podcast with his wife Alicia, an elaborate scheme to get her into X-Men comics disguised as a podcast. He's a full time videographer, photographer and drone pilot who teaches and performs improv comedy in spare time. Outside of work you'll find him playing disc golf, snowboarding, and exploring the great outdoors. More of Lodro Rinzler's work can be found here and here and you can follow the podcast on Instagram at xmenpanelsdaily where we post X-Men comic panels...daily. Have a question or comment for a future episode? Reach out at xmenhoroscopes.com

Proven Health Alternatives
How Too Much Iron Wrecks Hormones and Longevity

Proven Health Alternatives

Play Episode Listen Later Aug 21, 2025 53:34


Most people think iron is only a concern if they're deficient, but too much iron can be just as dangerous. In this episode, I sit down with Dr. Christy Sutton, a leading figure in the study of iron imbalances, to explore the often-overlooked health epidemic of unrecognized iron overload. Anchored around her book, The Iron Curse, we discuss why outdated laboratory ranges often fail to detect these imbalances and why recognizing them is so crucial for long-term health. From there, we dive into the intricacies of iron metabolism and the need for updated functional health ranges tailored to healthy populations. Dr. Sutton explains how imbalances can signal underlying health problems and highlights the value of functional lab testing in catching issues conventional methods often miss. We also explore the role of genetic testing—especially for hereditary hemochromatosis—and how genetics and environmental factors work together to influence iron levels. Key Takeaways: Iron Imbalance Epidemic: Iron imbalances, particularly overload, are often underdiagnosed due to outdated lab ranges and misconceptions, representing a silent health epidemic. Functional vs. Conventional Ranges: Functional health ranges, as opposed to traditional lab ranges based on sick populations, are crucial for accurate diagnosis of iron-related health conditions. Importance of Genetic Testing: Genetic factors (hemochromatosis genes) play a significant role in iron overload, necessitating comprehensive testing beyond typical lab work. Dietary and Lifestyle Influences: Both high and low iron levels are influenced by diet, lifestyle, and, importantly, how iron interacts with other nutrients and lifestyle factors like exercise. Gender and Iron Requirements: Iron needs differ significantly by sex and life stages, with menstrual and post-menopausal women, as well as men, needing tailored iron management strategies. More About Dr. Christy Sutton, D.C.: Dr. Christy Sutton is interested in asking why health problems happen and finding the safest and least problematic solutions. Her work takes a deep and meaningful dive into genomics, labs testing and creating a personalized health plan. Her focus on finding and avoiding health landmines early stems from her personal experience with Crohn's and celiac disease plus her husband's experience with high iron, hemochromatosis, and a pituitary tumor that likely was associated with having undiagnosed hemochromatosis. Website Instagram Connect with me! Website Instagram Facebook YouTube This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more! This episode is also made possible by Functional Medicine University. FMU is a fully online, self-paced training program in functional medicine, founded in 2006 by Dr. Ron Grisanti. With students in all 50 U.S. states and 68 countries globally, FMU has become a cornerstone in advanced clinical education for healthcare practitioners. The curriculum is led by Dr. Grisanti, alongside contributions from over 70 distinguished medical experts on FMU's advisory board. Graduates earn the prestigious Certified Functional Medicine Practitioner (CFMP®) credential upon completion. FMU is also a nationally approved provider of continuing education for a wide range of licensed professionals, including MDs, DCs, DOs, NDs, acupuncturists, PAs, NPs, nurses, dietitians, pharmacists, and dentists. Whether you're looking to expand your clinical knowledge or bring a functional approach to your practice, FMU offers the tools, guidance, and certification to help you thrive. Visit www.functionalmedicineuniversity.com to learn more!

This Week in Evolution
TWiEVO 117: Genes that don't leave

This Week in Evolution

Play Episode Listen Later Aug 20, 2025 98:13


Nels and Vincent discuss research on hidden evolutionary constraints that dictate the retention of coronavirus accessory gene, which was flagged by NIH as potentially dangerous gain-of-function research. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Hidden evolutionary constraints and retention of coronavirus accessory genes (Curr Biol) Timestamps by Jolene Science Picks Nels – NIH suspends dozens of pathogen studies over ‘gain-of-function' concerns and Mentorship and acts of kindness Vincent – Kennedy's case against mRNA vaccines collapses under his own evidence Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Juan Ep Is Life
The Absence of Street Genes

Juan Ep Is Life

Play Episode Listen Later Aug 19, 2025 58:40


Follow The Show:PatreonDiscordYoutubeInstagramX(Twitter)Follow Cipha Sounds:InstagramX(Twitter)TikTokFollow Rosenberg:InstagramX(Twitter)TIkTokThis podcast is sponsored by Monster Energy and Monster Music. Hosted on Acast. See acast.com/privacy for more information.

Culture Hang
JD Vance's Unwelcome Holiday, Sydney Sweeny's Genes Ad & Taylor Swift New Album

Culture Hang

Play Episode Listen Later Aug 19, 2025 60:55


This week we talk all about the pop culture we've missed over the past couple of weeks!We have a Patreon! We have two bonus episodes per month: Celebrity Corner and Bad Book Club, released each month! If you want to hear more from us, support us ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠!Join our Culture Gang! Email us at culturehangpodcast@gmail.com and follow us on instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@culturehangpodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

One in Six Billion
Series 4 episode 4. Chris Bright and Rob Andrews. Type 1 diabetes and Elite Sport.

One in Six Billion

Play Episode Listen Later Aug 19, 2025 36:46


Chris Bright was diagnosed with Type 1 diabetes aged 8 but this did not stop him having a very successful football career including playing international futsal for Wales. He describes the challenges he faced and how he over came them.  He has established The Diabetes Football Community that supports football for everyone living with Type 1 diabetes. Dr Rob Andrews helps people with Type 1 diabetes compete in all sports at the highest level.  He has set up the Exercise for Type 1 Diabetes (EXTOD) education program for patients and healthcare professionals.Send us a text

Huberman Lab
Using Stem Cells to Cure Autism, Epilepsy & Schizophrenia | Dr. Sergiu Pașca

Huberman Lab

Play Episode Listen Later Aug 18, 2025 143:29


My guest is Dr. Sergiu Pașca, MD, professor of psychiatry and behavioral sciences at Stanford University. We discuss the biology and genetics of autism, why autism diagnoses are increasing and recent progress in using stem cells to understand and treat profound autism and other brain disorders. Dr. Pașca explains “organoids and assembloids”—human stem cell–derived tools he pioneered to study, treat and cure complex brain diseases. We also discuss ethical and safety issues with using gene editing and stem cells in humans. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Helix: https://helixsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00) Sergiu Pașca (02:08) Autism Spectrum Disorder, Incidence, Genetics (07:16) Is Autism More Common in Males? (09:35) Sponsors: David & Helix Sleep (11:56) Eye Contact in Babies, Fever; Proposed Causes of Autism; Genes (18:48) Genetic or Idiopathic Autism Diagnoses, Timothy Syndrome (21:37) Rise in Autism Diagnoses (26:46) Cause, Correlation & Neurological Disease; Schizophrenia, Do Vaccines Cause Autism? (31:34) Global Increase in Autism; Gene Therapy, CRISPR, Follistatin (41:05) Sponsors: AG1 & BetterHelp (43:41) Stem Cells, Ethics, Yamanaka Factors, Human Stem Cell Models (52:03) Umbilical Stem Cells; Stem Cell Injections & Dangers, Autistic Kids (59:30) Organoids, Modeling Brain Development, Intrinsic Development Timer (1:12:22) Assembloids, Brain Cell Migration & Circuit Formation, Self-Organization (1:21:22) Four-Part Assembloid, Sensory Assembloid, Pain Conditions (1:25:45) Sponsor: Function (1:27:33) Future Medical Therapies, Cell Banking, Immortalize Tissues, Rejuvenate Cells (1:34:56) Assembloids & Ethics, Importance of Nomenclature, Science Collaboration & Self-Correction (1:45:38) Cell Transplantation & Ethics, Timing (1:55:05) Genetic Testing for Parents, Genetic Penetrance (2:02:36) Assembloids, Timothy Syndrome, Epilepsy, Schizophrenia, Dystonia (2:14:30) Scientific Career, Walking, Art, Medical School (2:20:44) Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Fearless with Jason Whitlock
Allie Beth Stuckey REACTS: Sydney Sweeney & ‘Great Genes' | Jason Whitlock Harmony

Fearless with Jason Whitlock

Play Episode Listen Later Aug 18, 2025 21:32


Allie Beth Stuckey joins Jason to discuss the viral controversy surrounding Sydney Sweeney's American Eagle ad and the reactions it received. They also explore why conservatives on social media are celebrating attractive women on the internet. Learn more about your ad choices. Visit megaphone.fm/adchoices

Public Health On Call
934 - Sickle Cell Disease: Genetic Therapies and Treatment Hurdles

Public Health On Call

Play Episode Listen Later Aug 18, 2025 25:04


About this episode:  Sickle cell disease affects an estimated 100,000 people in the United States. Recent advancements in gene therapies and medicines like hydroxyurea are diminishing extreme pain, reducing strokes, and extending survival times for those afflicted by the disease. In this episode: leading sickle cell disease expert Dr. Mark Gladwin explains how revolutionary new treatments work and discusses the challenges to access to life-saving care. Guest: Dr. Mark Gladwin is a physician-scientist and the Dean of the University of Maryland School of Medicine and Vice President for Medical Affairs at the University of Maryland, Baltimore. His research focuses include sickle cell disease and hypertension. Host: Dr. Josh Sharfstein is vice dean for public health practice and community engagement at the Johns Hopkins Bloomberg School of Public Health, a faculty member in health policy, a pediatrician, and former secretary of Maryland's Health Department. Show links and related content: New sickle cell gene therapies are a breakthrough, but solving how to pay their high prices is a struggle—CNBC Gene Therapy: What You Need to Know—Sickle Cell Disease Association of American No More Pain: Breakthrough Sickle Cell Treatment from Johns Hopkins Offers Curative Potential—Johns Hopkins School of Medicine Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌JohnsHopkinsSPH on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

Resiliency Radio
274: Resiliency Radio with Dr. Jill Decoding Autoimmunity: How Environment and Nutrition Shape our Genes with Dr. Dennis Hooper

Resiliency Radio

Play Episode Listen Later Aug 18, 2025 44:18


Dr. Jill sits down with Dr. Dennis G. Hooper, M.D., Ph.D. to decode the mysteries of autoimmunity and explore how environment and nutrition shape our genes. Dr. Hooper shares his remarkable journey from traditional medicine to integrative and functional medicine, offering insights into groundbreaking programs on inflammasomes and their critical role in autoimmune conditions. Together, Dr. Jill and Dr. Hooper dive deep into the effects of environmental exposures like arsenic and iron contamination, while highlighting the role of nutritional genetics in restoring health. You'll also discover the innovative Silver Gene Initiative, designed to transform patient care with faster lab testing and more accessible results. This conversation emphasizes the importance of teaching, collaboration, and community in medicine—and how collective knowledge can revolutionize healthcare for the future.

Feminine Chaos
Premium: My Genes Are Wilder

Feminine Chaos

Play Episode Listen Later Aug 18, 2025 9:55


This is a free preview of a paid episode. To hear more, visit femchaospod.substack.comKat and Phoebe discuss a certain comedienne's May-December relationship that was (or, possibly, wasn't), the forever war over Sydney Sweeney's genes, and whether anti-woke signaling as advertising strategy is a terrible mistake, or just a happy little accident.LINKS:Kat on the Sydney Sweeney debacle: Hot Girl Wears Denim, Fourth Reich ImminentNick Asbur…

Science Salon
Can We Prevent Aging? Eric Topol on Genes, Lifestyle, and AI in Healthcare

Science Salon

Play Episode Listen Later Aug 16, 2025 61:05


In this conversation, Michael Shermer and Dr. Eric Topol discuss the realties of aging, with particular focus on the role of AI in enhancing patient care and disease prevention, the importance of lifestyle factors, and the limitations of genetic testing in predicting health outcomes. Topol also explains the dangers of ultra-processed foods, their link to inflammation, and the role of GLP-1 drugs in promoting healthier eating habits. The conversation also covers diet, particularly the differences between chicken and red meat, and the significance of sleep for overall health. Plus, consumption of microplastics, cholesterol management and statins, the critical role of social connections in maintaining mental and physical health, and the future of personalized medicine in cancer prevention. Eric Topol is a cardiologist and one of the top ten most cited researchers in medicine, known for his groundbreaking studies on AI in medicine, genomics, and digitized clinical trials. Topol is also the executive vice president and a professor of molecular medicine at Scripps Research, the largest nonprofit biomedical institute in the United States. He was named one of the Top 100 most influential people in health in 2024 by Time. His new book is Super Agers.

The Secret Teachings
Baskin in Poison w. Mike D - 3 hour Special (8/15/25)

The Secret Teachings

Play Episode Listen Later Aug 16, 2025 213:01 Transcription Available


Longtime cohost Mike D rejoins the show for a special 3 hour + investigation of the new Baskin Robbins new advertisement, Dunkin Donuts ingredient lists, and American school lunches vs those from oversees. As the MAHA movement seeks to change schools lunches, opponents argue that it is difficult, expensive and laborious, yet other countries with less money and resources have already perfected the school lunch. So what is going on in the U.S.?*The is the FREE archive, which includes advertisements. If you want an ad-free experience, you can subscribe below underneath the show description.FREE ARCHIVE (w. ads)SUBSCRIPTION ARCHIVEX / TWITTER FACEBOOKWEBSITECashApp: $rdgable EMAIL: rdgable@yahoo.com / TSTRadio@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-secret-teachings--5328407/support.

WudUpDoe Podcast
Episode 411: Good Genes

WudUpDoe Podcast

Play Episode Listen Later Aug 13, 2025 70:25


Wudupdoe! So our government is arguing about jeans? Are they trying to cover up Epstein? The Hulkster passed at some point of our mini break.. and more.

CONOCE  AMA Y VIVE TU FE
Episodio 1164: Sydney Sweeney¿Genes Superiores? | Comercial Nazi |La Raza Perfecta | Linaje En La Biblia

CONOCE AMA Y VIVE TU FE

Play Episode Listen Later Aug 12, 2025 47:27


Envíame un mensajeEscándalo con un comercial de American Eagles sobre jean (pantalones) y los genes de Sydney Sweeney ¿Que dice la biblia sobre los linajes?Support the show YouTube Facebook Telegram Instagram Tik Tok Twitter

Bounced From The Roadhouse
Big Surprise, Fact to the Future, Macaulay Culkin Stunt Double, Good Genes, Strip Club Janitor and More.

Bounced From The Roadhouse

Play Episode Listen Later Aug 12, 2025 32:00


On this episode of Bounced From The Roadhouse:Special Guests in 4B:My Big Surprise12-Hour Road Trip One SingerLayover at AirportFACT TO THE FUTUREMacaulay Culkin Stunt DoubleA Giant Tub of Mayonnaise Married My FriendsMayo in High SchoolGood GenesThat's a Great QuestionStrip Club JanitorWhat Happens When We DieFairQuestions? Comments? Leave us a message! 605-343-6161Don't forget to subscribe, leave us a review and some stars Hosted on Acast. See acast.com/privacy for more information.

Lunaticoin
L268 - ¿Son sostenibles las Tesoreras Bitcoin? Mesa Redonda con Alberto, Diógenes, Jesús y Emérito

Lunaticoin

Play Episode Listen Later Aug 12, 2025 143:41


Mesa Redonda para analizar el caso positivo y negativo (sobretodo negativo) de las Tesoreras Bitcoin con Alberto Mera, Diógenes Casáres y Jesús Pérez de Crypto Plaza con participación de Emérito Quintana. Links: https://x.com/alberto_merahttps://x.com/DiogenesCasareshttps://x.com/especulacionhttps://x.com/foso_defensivoMás en mi entrada en el Blog y la charla con Emérito en PatreonRecibe el podcast en tu correo. Únete!

Brant & Sherri Oddcast
2246 SPECIAL PODCAST: The Matter with Things

Brant & Sherri Oddcast

Play Episode Listen Later Aug 11, 2025 39:37


Topics:  In this bonus episode, Brant talks about what he's learning from the book: "The Matter With Things" by Iain McGilchrist. Including: - Exploring the complexity and intelligence of living cells. - Challenging purely mechanical views of biology. - Why relationships and context are paramount.   And most importantly…   The many spiritual parallels that can be derived from the book and how who we are becoming matters way more than our past.     Quotes: “Life requires cognition at all levels. Our cells think!” “Genes do nothing on their own; life is far more than DNA.” “Flatworms can regrow their brains and still remember.” “Healing is God's work; medicine cooperates with it.” . . . Holy Ghost Mama Pre-Order! Want more of the Oddcast? Check out our website! Watch our YouTube videos here. Connect with us on Facebook! For Christian banking you can trust, click here!

Business Pants
Intel CEO Tan's Trump problem, AT&T CEO Stankey's memo, and Duolingo's new “manbro” language

Business Pants

Play Episode Listen Later Aug 8, 2025 59:22


Story of the Week (DR):Trump Demands Intel CEO's Resignation, Says He's ‘Highly CONFLICTED' AND Eric and Donald Trump Jr. to Own Millions of Shares in New U.S. Manufacturing SPAC MMESG Analyst Tom Cotton: Trump's attack, posted on Truth Social Thursday, came two days after GOP Sen. Tom Cotton flagged Tan's prior investments in Chinese companies and his previous leadership at Cadence Design Systems, which recently pleaded guilty to unlawfully selling its tech to a blacklisted military university in China.Intel CEO Lip-Bu Tan (~$70M golden hello in March; max potential $400M) directly addressed employees on Thursday after Donald Trump demanded his resignation over national security concerns, saying he has the full support of the board.Tan set up a venture firm called Walden International based in San Francisco that pumped more than $5 billion into over 600 companies. More than 100 of those investments were made in China, including deals with once-obscure startups such as Semiconductor Manufacturing International Corp.—today China's largest chipmaker—where he served on the board for a decade and a half.Today, the executive is still chairman of Walden International. And he's the founding managing partner at Walden Catalyst Ventures, which focuses on investments in the U.S., Europe and Israel. He also serves in that role at another venture fund, Celesta Global Capital.Tan stepped out of the venture world and joined the chip industry full-time when he became interim head of San Jose, California-based Cadence Design Systems Inc. in 2008. The executive, who had previously served on the board, went on to take the permanent CEO job the next year. He stayed in the role until 2021, when he transitioned to executive chairman, and is widely credited with restoring the company's fortunes. In late July of this year, the Department of Justice announced a plea deal that cost Cadence more than $100 million in fines. Employees at Cadence's China unit allegedly hid the name of a customer—the National University of Defense Technology—from internal compliance in order to keep supplying it. That organization had been put on the Department of Commerce's blacklist in 2015. The Chinese university was one of a group of supercomputer operators there that had conducted simulations of nuclear explosions, the DOJ said.Shares of American Eagle surge 20% after Trump calls Sydney Sweeney campaign 'hottest ad out there' AND Epstein victims are a growing political threat to TrumpThe Fall 2025 campaign, titled "Sydney Sweeney Has Great Jeans," centers on a deliberate pun between "jeans" and "genes.""Genes are passed down from parents to offspring, often determining traits like hair color... My jeans are blue."All the hallmarks of a dick-tatorship:American Eagle gender influence gap is -36%: Jay L. SchottensteinMr. Schottenstein has served as our Chief Executive Officer since December 2015. Prior thereto, he served as our Interim Chief Executive Officer from January 2014 to December 2015. He has served as Chairman of the Board since March 1992. He previously served the Company as Chief Executive Officer from March 1992 until December 2002 and as a Vice President and Director of the Company's predecessors since 1980Creepy nepobaby son: The grown son of an Ohio billionaire is a hooker-loving drug addict who threatened to destroy the renowned Manhattan psychiatrist his parents enlisted to help him, according to bombshell court papers. Dr. Paul Conti, a Stanford-educated psychiatrist from Oregon, alleges in a federal suit that the son also gambled away millions of dollars during trips to Las Vegas while running up credit bills and borrowing money from mobsters.SB360 Capital Partners: owned by Jay and his 3 sons (sorry wife): 13 listed executes: all white menlast time there was a vote on Jay (2023)CEO/Chair control: has been CEO 3 times; chair since 1992; $300k security; 2,011:1 ceo pay ratio; 7% of shares (passive BlackRock/Vanguard/Dimensional/Wellington: 41%; 71% board influenceAudit Committee Chair (which net 20 times last year) and Lead independent Director Noel Spiegel is 77 and over a decade of serviceNominating chair Janice Page is 76 and has served for over 2 decadesCompensation Committee chair has served for nearly 2 decadesUber's Sexual Assault Problem AND Uber beats on revenue, announces $20 billion stock buybackA recent New York Times investigation revealed that Uber has been dealing with a significant sexual assault problem. From 2017 to 2022, the company received over 400,000 reports of sexual assault or misconduct in the United States, which averages to about one incident every eight minutes.The investigation, based on thousands of internal documents, found that while Uber studied the issue and even developed potential safety features like in-car cameras and a feature to match female drivers with female passengers, the company chose not to implement these safeguards because they were concerned about their bottom line and potential lawsuits.Tesla Grants Musk $29 Billion in Stock to Keep ‘Elon's Energies Focused' AND Elon Musk Accused of Stiffing Small Businesses for Millions of Dollars, Causing Some to File for Bankruptcy AND Elon Musk Shares Shockingly Sexist Tweet About Woman Being Property. This one's disgraceful, even for Musk AND "This Will Open the Floodgates": Tesla In Trouble as Jury Orders It to Pay $329 Million After Autopilot Death AND Tesla withheld data, lied, and misdirected police and plaintiffs to avoid blame in Autopilot crash AND Elon Musk Appears to Now Be the Most Hated Person in America, According to New ResearchGoodliest of the Week (MM/DR):DR: Waste from Ben & Jerry's ice cream factories is now powering the Vermont gridNow that the ice cream waste can travel by pipe to become biogas, Ben & Jerry's can also make 600 fewer truck journeys a year, reducing the company's carbon emissions.DR: Gates Foundation is giving $2.5 billion to fund women's health research MM: Musk, Bezos, and Zuck are going full alpha male. America's girlbosses are fed up.When companies won't offer work-from-home policies or the flexibility that working parents need, it can embolden people to become more entrepreneurial and build under their own terms.This is the greatest backlash - if every woman in a “masculine default”, “founder mode” 13 year old man baby culture where “Jamie Dimon says” and John Stankey (see assholiest) says “maybe you don't fit” goes and founds there own firms, I'm giddy to see them wipe the floor with those smug billionaire assholes. Side note - I missed this quote from January FT article in the post-Zuck-on-Rogan “masculine energy” interview, but it would have been assholiest of the decade:“I feel liberated,” said a top banker. “We can say ‘retard' and ‘pussy' without the fear of getting cancelled . . . it's a new dawn.”MM: In that vein - A long-running anti-DEI lawsuit could help companies defend themselves from reverse-racism claims DR MMHello Alice as goodliest of the week - take down that fucknut Stephen Miller and his fake Nazi manboys.Assholiest of the Week (MM):Alex Karp and the men who go to elite universities and say elite universities are bullshit manbabiesPalantir CEO says working at his $430 billion software company is better than a degree from Harvard or Yale: ‘No one cares about the other stuff'Karp went to Haverford, then Stanford for a JD where he met Peter Thiel (who also doesn't like elite education)This past spring, the company also notably established the Meritocracy Fellowship, a four-month, paid internship for high school graduates who may be having second thoughts about higher education. Program admission is solely based on “merit and academic excellence,” but applicants still need Ivy League-level test scores to qualify. This includes at least a 1460 on the SAT or a 33 on the ACT, which are both above their respective 98th percentiles.According to Karp, the internship was created in direct response to the “shortcomings of university admissions.”Here's the problem: there ARE shortcomings to elite colleges, mostly that they exude exclusivism and a commodity - but it's still a pretty rich for a guy who WENT to Stanford where he met his future funder and mentor to talk about how bullshit it wasJohn Stankey and the re-rise of the Jack Welch man-directive manbabies MMIt is incredibly encouraging that 73% of our employees took the time to respond to the survey, with 79% of those respondents feeling committed and engaged with their work at AT&T. While this is reassuring, especially considering the amount of change we've navigated as a company recently, it wasn't a surprise to me that we fell short of our engagement goal.TRANSLATION: I'm not surprised so many of you think we suck, I've been here 5 years as CEO and I'm not awesome at my job… but hold your breath while I tell you how it's your faultThis note may also help you identify areas where your professional expectations might be misaligned with the strategic direction of this company.TRANSLATION: It's your faultI understand that some of you may have started your tour with this company expecting an "employment deal" rooted in loyalty, tenure, and conformance with the associated compensation, work structure, and benefits. We have consciously shifted away from some of these elements and towards a more market-based culture — focused on rewarding capability, contribution, and commitment.TRANSLATION: Fuck your job, this is a meritocracy now. A manly meritocracy.I understand that many may find the demands of your daily lives challenging and difficult. Elder care, job stress, child rearing challenges, economic uncertainty, community unrest, technology anxiety — the list can get long…We run a dynamic, customer-facing business, tackling large-scale, challenging initiatives. If the requirements dictated by this dynamic do not align to your personal desires, you have every right to find a career opportunity that is suitable to your aspirations and needs. That said, if a self-directed, virtual, or hybrid work schedule is essential for you to manage your career aspirations and life challenges, you will have a difficult time aligning your priorities with those of the company and the culture we aim to establish.TRANSLATION: We know your life is hard, but shut the fuck up about it because I don't care.WHERE THE FUCK IS THIS BOARD?Here are the “go hard or go home” board membersBill Kennard, lead "independent" director connected in 13 loops to other directors, been there for 11 years, who got his undergrad in communications from Stanford and worked at the FCC and was an ambassador - proving once again that “communications” isn't a qualification for communicating?Marissa Mayer - maybe this business thing isn't for you? Mike Mcallister, ex Humana CEO, who was investigated for duping elderly into thinking Obamacare's passage would cut Medicare?Scott Ford, who lead the biggest landline company before pivoting to selling coffee, as your bright star into the future of tech?That's where the board is - unqualified for the moment, highly interconnected, with long careers of average performanceLuis von Ahn and the tech bro “sorry, not sorry” we were just “being edgy” no but seriously I know what's best for you secretly manbabiesDuolingo's CEO says he learned a hard lesson about 'edgy posts' and going viralFirst, says Duolingo, the app for learning languages, would be “AI-first”Then says they're not hiring anymore as long as it can be done by AIThen says schools will really just be childcare with AI teachers, and teachers will just “take care of the children” and you need schools for the “childcare”In his apology, he said sorry for being “edgy”Yes, it was the edginess, not the assholeryIf you want to quickly identify a manbaby, it's easy: first they “say” something they really think, then their apology basically is “sorry you didn't get it, I won't say it again”Headliniest of the WeekDR: Shareholders Judge Directors by Their Faces, Study FindsMM: Trump calls for Intel CEO to 'resign immediately'More ESG analysis:Boeing's ex-CFOBlackRock's ex founderThe former CEO at Jack Dorsey's SquareA partner at SequoiaA Princeton professorThe former CEO of HPThe chair who's a VC and has been there since 2009Who Won the Week?DR: Boston Mayor Michelle Wu for calling out the billionaire Kraft family regarding the new stadium proposed for the New England Revolution: “We haven't asked for anything out of the ordinary for any significant development, much less a mega-development like this one … To this day, the Kraft Group has provided the city no meaningful technical information … What we've heard has stayed at a conceptual level that is insufficient for any serious negotiation.Citing the proposed figure of $750,000 that the Kraft Group would pay to Boston as a mitigation fee, Wu said, “It is an unserious proposal … the figure is “just 1.1 percent of the $68 million mitigation package that was paid for the Everett casino project right nearby years ago.”Wu, who as the incumbent is also campaigning against Josh Kraft (son of Revolution owner Robert Kraft) in Boston's mayoral race, didn't miss a chance to land a political dig at her opponent: Referencing the proposed mitigation fee, she said that “$750,000 is just one-and-a-half month's of a billionaire son's allowance. It is nowhere near the scale of what we need to address the plans that have already been laid out by our residents, with our traffic engineers, with the coordination of the entire region.”MM: Jamie Smith at EY for writing the only other 2025 US proxy review that included a whole section on director votesPredictionsDR: Trump tries to fit into a pair of Sydney Sweeney's jeans (re: the OJ glove) to prove he did not know Epstein. The American Eagle stock surgesMM: Duolingo releases a new language choice, “Manbro”, in which it teaches how to apologize, how to be more intense, and why you should bow to your AI overlords

Decoding Fox News
Podcast # 174 - What Epstein Files? Sydney Sweeney Has Blue Genes!

Decoding Fox News

Play Episode Listen Later Aug 7, 2025 61:17


Last week the folks at Fox News pretended the ‘Epstein files' didn't exist while everyone at the network got extremely worked up over an American Eagle commercial that featured the actress, Sydney Sweeney. The advertisement was yet another culture war fixation meant to distract from Trump's possible involvement with the sex trafficking of underage girls.The political furor surrounding the Epstein files has reached the rare distinction of being a bipartisan crusade. Americans across the political spectrum have become obsessed with the mysterious circumstances surrounding Jeffrey Epstein's death, his once close relationship with the president of the United States and the secrecy surrounding documents related to his alleged sex trafficking operation.Trump and his intelligence officials promised they would declassify everything related to Jeffrey Epstein once they had the power to do so. After months of excuses Attorney General Pam Bondi, FBI Director Kash Patel along with Deputy Director Dan Bongino told the American public that there was nothing to reveal. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit decodingfoxnews.substack.com/subscribe

Ratchet & Respectable
In Those Jeans/Genes

Ratchet & Respectable

Play Episode Listen Later Aug 6, 2025 46:57


Demi in Martha's Vineyard (on Appleton Estate); Shannon Shape is more than just a dirty old man; Mad Black people just got re-married; And Just Like That (Finally) Cancelled; Mad Spoilers for The Gilded Age; Beyoncé joins the jeans/genes controversy. Learn more about your ad choices. Visit podcastchoices.com/adchoices

FluentlyForward
Why Donald Trump Loves Sydney Sweeney's "Great Genes"

FluentlyForward

Play Episode Listen Later Aug 6, 2025 70:24


America's sweetheart - or the face of a quiet eugenics campaign? In this episode, we unpack the new Sydney Sweeney x American Eagle ad that's been praised by the right as a return to “traditional American values” — and why it has people whispering about the Great Replacement Theory. From Trump chiming in to say he “loves it” to online conservatives treating Sydney like the poster girl for “healthy, white motherhood,” we explore how fashion branding becomes soft propaganda, how the ad taps into white nationalist aesthetics, and why it's never just denim. Check out ⁠⁠⁠⁠⁠⁠https://www.squarespace.com/fluently⁠⁠⁠⁠⁠⁠ to save 10% off your first purchase of a website or domain using code FLUENTLY Elevate your closet with Quince. Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Quince.com/fluently⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ for free shipping on your order and 365 -day returns.

National Crawford Roundtable
Episode 312-Trump Firing of BLS Commissioner, Texas Democrats Fleeing the State, and the AE Good Jeans (Genes) Ad Controversy

National Crawford Roundtable

Play Episode Listen Later Aug 6, 2025 55:50


In this episode of the National Crawford Roundtable podcast the guys discuss Trump's firing of the Bureau of Labor Statistics Commissioner. This week's topics include: should Trump fire Fed Chairman Jerome Powell for refusing to lower interest rates? What can or should be done about Texas Democrats fleeing the state to block Republicans from Gerrymandering Congressional Districts? And the guys talk about the "controversy" surrounding American Eagle's "Good Jeans (Genes) ad featuring Sydney Sweeney.

Health Gig
563. Biohacking Your Genes: Dr. Sharad Paul on Becoming a Super-Ager, Pt. 2

Health Gig

Play Episode Listen Later Aug 6, 2025 36:52


Doro and Tricia welcome Dr. Sharad Paul, a skin cancer specialist and social entrepreneur, to talk about the health research outlined in his latest book, "Biohacking Your Genes: 25 Laws for a Smarter, Healthier, and Longer Life." Dr. Paul talks about non-physical factors that can contribute to aging and wellness, emphasizing the equal importance of movement, personalized health strategies, lifestyle choices and happiness. He addresses a few common myths about supplements and skin care, ultimately highlighting for listeners the significance of being intentional about seeking information and a balanced lifestyle. This is the second of a two-part episode.

Where To Stick It
Episode 473 - After Dark 145: A Fantastic Review

Where To Stick It

Play Episode Listen Later Aug 5, 2025 53:54


On this Fantastic episode of the Where to Stick It Podcast, the boys honor the passing of wrestling icon Hulk Hogan, which they predicted in an earlier episode after speculation of his health, by watching some old matches, everyone is losing their minds over Sydney Sweeney's jeans (or genes), Pete Prospect and Lobo all saw The Fantastic Four: First Steps and give a review, and we sign off with a few upcoming movie trailers.Support the showCatch new episodes of the Where to Stick It Podcast every Tuesday and Thursday. If you like the show, please consider supporting us on Patreon where we upload exclusive content each month for only $3 a month.

Candace
Tucker Carlson And I Discuss Brigitte's Genes & Trump Commits Treason. | Candace Ep 223

Candace

Play Episode Listen Later Aug 4, 2025 60:04


I recap my interview with Tucker Carlson, Trump withholds disaster funds for states unless they support Israel, and an unexpected group of people have come to my side and issued a public letter to Brigitte Macron. 00:00 - Start. 01:03 - My interview with Tucker. 04:29 - The Saint Laurent/Macron connection. 24:43 - Trump to withhold disaster funding for states and cities who boycott Israel. 33:10 - Hunter Biden's Channel 5 interview. 48:32 - Comments. GoldCo Get a FREE gold & silver kit! #goldcopartner http://www.candacelikesgold.com Just Thrive Get 20% off your order with promo code CANDACE at https://justthrivehealth.com PureTalk Make the switch today and get a FREE Samsung Galaxy A36 with a qualifying plan at http://www.PureTalk.com/Owens American Financing Call American Financing today to find out how customers are saving an avg of $800/mo. 800-795-1210 or visit http://www.AmericanFinancing.net/owens NMLS 182334, https://www.nmlsconsumeraccess.org Candace Official Website: https://candaceowens.com Candace Merch: https://shop.candaceowens.com Candace on Apple Podcasts: https://t.co/Pp5VZiLXbq Candace on Spotify: https://t.co/16pMuADXuT Candace on Rumble: https://rumble.com/c/RealCandaceO Learn more about your ad choices. Visit megaphone.fm/adchoices

The Most Dramatic Podcast Ever with Chris Harrison
American Eagle Responds To Sydney Sweeney Good Jeans/Genes Ad

The Most Dramatic Podcast Ever with Chris Harrison

Play Episode Listen Later Aug 3, 2025 31:44 Transcription Available


After a week of controversy from an online AE ad that went all the way up to the White House, American Eagle finally issued a statement. BUT, as Amy and T.J. discuss, that statement pissed some people off even more than the original ad! The question, should we be mad, or should we be asking ourselves WHY we’re so mad and how can we all do better?See omnystudio.com/listener for privacy information.

Amy and T.J. Podcast
American Eagle Responds To Sydney Sweeney Good Jeans/Genes Ad

Amy and T.J. Podcast

Play Episode Listen Later Aug 3, 2025 31:44 Transcription Available


After a week of controversy from an online AE ad that went all the way up to the White House, American Eagle finally issued a statement. BUT, as Amy and T.J. discuss, that statement pissed some people off even more than the original ad! The question, should we be mad, or should we be asking ourselves WHY we’re so mad and how can we all do better?See omnystudio.com/listener for privacy information.

How Men Think with Brooks Laich & Gavin DeGraw
American Eagle Responds To Sydney Sweeney Good Jeans/Genes Ad

How Men Think with Brooks Laich & Gavin DeGraw

Play Episode Listen Later Aug 3, 2025 31:44 Transcription Available


After a week of controversy from an online AE ad that went all the way up to the White House, American Eagle finally issued a statement. BUT, as Amy and T.J. discuss, that statement pissed some people off even more than the original ad! The question, should we be mad, or should we be asking ourselves WHY we’re so mad and how can we all do better?See omnystudio.com/listener for privacy information.

FLF, LLC
Crosspolitic Has Good Genes—And So Do You [CrossPolitic Show]

FLF, LLC

Play Episode Listen Later Aug 1, 2025 50:52


In today's show Pastor Toby and The Chocolate Knox cover recent American Eagle Ad involving Sydney Sweeney's "jeans" that has the left in an up cry and the right in an uprooting applause. Also appearing to weigh in on this is former pastor Jason Farley , Teaching Pastor Virgil Walker, and mother of 7 (and Knox's wife) Sharron Shannon! With such a stacked roster of speakers, this turned out to be an informal conversation diving deeper into the implications of this supposedly racist ad. Fight Laugh Feast 2025 Conference (October 16-18, Nashville) - Register HERE: https://flfnetwork.com

The Federalist Radio Hour
‘The Kylee Cast' With Kylee Griswold, Ep. 4: Sydney Sweeney And Seditious Conspiracy

The Federalist Radio Hour

Play Episode Listen Later Jul 31, 2025 43:53


On this episode of The Kylee Cast, Federalist Managing Editor Kylee Griswold explains why somebody's got to go to prison for the Russia hoax. Plus, the Federalistas discuss Sydney Sweeney's great jeans, and Kylee shares why the new Fantastic Four movie is the most pro-life Hollywood blockbuster of all time.If you care about combating the corrupt media that continue to inflict devastating damage, please give a gift to help The Federalist do the real journalism America needs.

Garage Logic
Crabby: If you are angry at the Sydney Sweeny ad for American Eagle jeans, that's a YOU problem...........

Garage Logic

Play Episode Listen Later Jul 30, 2025 38:11


If you are angry at the Sydney Sweeny ad for American Eagle jeans, that's a YOU problem...........Sydney Sweeney Under Fire After Controversial American Eagle Ad CampaignThe label's latest advertising campaign has been setting social networks ablaze, and not just because it features the Euphoria actor in a tight tank top. Called “Sydney Sweeney Has Great Jeans,” it's based around a play on words that may seem harmless—but has been criticized by onlookers who see a sinister message lurking beneath the pun.One ad from the autumn campaign shows Sweeney leaning over the engine of her Ford Mustang. She slams the hood and wipes her hands on the back of her jeans—not without a close-up from the cameraman—before settling behind the wheel and disappearing. A second begins with Sweeney speaking about her “jeans” as the camera slowly pans down to her cleavage, before she reprimands it with a smiling “Hey, eyes up here!” The series' most criticized ad shows the actor reclining on a couch as she squirms while fastening her pants and murmuring, “Genes are passed down from parents to offspring, often determining traits like hair color, personality, and even eye color. My genes are blue.” Then a male narrator concludes, “Sydney Sweeney has great jeans.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Jesse Kelly Show
Hour 1: The Genes

The Jesse Kelly Show

Play Episode Listen Later Jul 30, 2025 37:51 Transcription Available


Sydney Sweeney in jeans is a racist dog whistle? Communism is all they care about. They don’t care about violence or hypocrisy. They only care about communism. Destruction is the goal. Why is there so much backlash from The Left over a jean ad? Follow The Jesse Kelly Show on YouTube: https://www.youtube.com/@TheJesseKellyShowSee omnystudio.com/listener for privacy information.

The Chris Plante Show
7-30-25 Hour 2 - Referencing Jeans/ Genes now Fascist

The Chris Plante Show

Play Episode Listen Later Jul 30, 2025 41:28


For more coverage on the issues that matter to you, download the WMAL app, visit WMAL.com or tune in live on WMAL-FM 105.9 from 9:00am-12:00pm Monday-Friday  To join the conversation, check us out on X @WMAL and @ChrisPlanteShow Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Daily Zeitgeist
American Eagle Pissed Genes, Men Bad At Dating Apps??? 07.29.25

The Daily Zeitgeist

Play Episode Listen Later Jul 29, 2025 62:35 Transcription Available


In episode 1904, Jack and Miles are joined by comedian, Blair Socci, to discuss… Dating Study Finds That Men Are…Holy Sh*t The Comment Section, Online PI’s Thriving, Sydney Sweeney Ad Campaign Is Taking Heat For Its Nazi Vibes and more! Dating Study Finds That Men Are…Holy Sh*t The Comment Section Online PI’s Thriving Sydney Sweeney poses in jeans, skips her top for new ad campaign Sydney Sweeney’s Spicy Jeans Campaign Sends American Eagle Stock Soaring Sydney Sweeney's American Eagle Ad Sparks Outrage, But Fans Praise Her For 'Killing Woke Advertising' Sydney Sweeney’s new campaign draws fire for racial undertones Know Your Meme: "Sydney Sweeney Has Great Jeans" American Eagle Ad Brooke Shields Says She Was "Naive" About Her Racy Calvin Klein Commercial SEE BLAIR SOCCI @ Dallas Comedy Club AUG. 2, 2025! LISTEN: Handle With Care by ConductaSee omnystudio.com/listener for privacy information.

Huberman Lab
Male vs. Female Brain Differences & How They Arise From Genes & Hormones | Dr. Nirao Shah

Huberman Lab

Play Episode Listen Later Jul 28, 2025 146:58


My guest is Dr. Nirao Shah, MD, PhD, a professor of psychiatry, behavioral sciences and neurobiology at Stanford University School of Medicine. We discuss how the brains of males and females differ and how those differences arise from different genes and hormones during fetal development, in childhood and adulthood. We discuss what drives male- versus female-specific behaviors and how hormonal fluctuations across the lifespan, including puberty, the menstrual cycle, menopause and aging – affect behavior, cognition and health. Additionally, we discuss how biology relates to gender identity and the impact of hormone therapies on brain circuits that regulate mating, parenting and social bonding. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui: https://mauinuivenison.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Nirao Shah 00:02:11 Mice, Humans & Brain, Biological Conservation 00:05:25 Hormones, Nature vs Nurture 00:07:13 Biological Sex Differences, Chromosomes & SRY Gene, Hormones 00:16:01 Sponsors: Maui Nui & Eight Sleep 00:19:09 Androgen Mutations, Feminization & Masculinization 00:22:04 SRY Gene; Animals & Sexual Trans-Differentiation 00:27:49 Hormones & Biological Brain Differentiation 00:31:22 Congenital Adrenal Hyperplasia, Androstenedione; Stress & Pregnancy 00:35:56 Genes, Brain Differentiation & Sexual Identity; Congenital Adrenal Hyperplasia 00:43:37 Testosterone, Estrogen & Brain Circuits 00:47:27 Sponsors: AG1 & LMNT 00:50:36 Intersex Individuals, Castration 00:52:23 Female Sexual Behavior, Brain, Testosterone & Pheromones 00:57:58 Identify as Heterosexual or Homosexual, Difference in Hormone Levels? 01:00:42 Gender, Sexual Orientation & Hormones; Hormone Replacement Therapy 01:10:21 Aromatization; Steroid Hormones & Gene Expression 01:15:00 Kids & Changing Gender Identity 01:19:05 Sexual Behavior, Refractory Period & Male Brain, Tacr1 Cells 01:21:31 Sponsor: Function 01:23:19 Hypothalamus, Dopamine, Prolactin, Cabergoline, Libido, Dopamine 01:27:05 Brain Circuits, Aggression & Sexual Behavior 01:32:40 Refractory Period; Age, Testosterone & Libido 01:36:07 Tacr1 Cells in Females, Periaqueductal Gray & Innate Behaviors 01:40:00 Parenting Behaviors & Brain Circuits; Pet Dogs 01:43:12 Oxytocin, Pair Bonding, Vasopressin; Biological Redundancy 01:47:22 Libido, Melanocortin, Tacr1 Neurons; GLP-1 Agonists, Clinical Trials; Kisspeptin 01:56:43 Female Brain Changes, Menstrual Cycle, Pregnancy, Menopause; Estrogen; Men & Hormone Fluctuation? 02:04:10 Life Experience Male vs Female, Sex Recognition, Behaviors & Context 02:16:05 Pain Management; Endocrine Disrupters, Gender Identity 02:21:03 Future Projects 02:24:29 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The Most Dramatic Podcast Ever with Chris Harrison
Of Course, Sydney Sweeney Has Good Genes/Jeans. So Why You Mad? 

The Most Dramatic Podcast Ever with Chris Harrison

Play Episode Listen Later Jul 28, 2025 24:04 Transcription Available


She's done it again! Sydney Sweeney has made a habit out of getting people worked up. This time, she's set the internet on fire and even sent stocks soaring ... All because of her genes/jeans. Amy and T. J. get into it about Sweeney's latest collaboration with American Eagle, and why the idea of a blonde-haired, blue-eyed white woman being celebrated for her "good genes" a reminder of one of the ugliest periods in human history.See omnystudio.com/listener for privacy information.