Podcasts about genes

  Are you doing everything "right" for your health and still not getting the results you expected? In this episode of the Sisterhood of S.W.E.A.T., Linda Mitchell sits down with Kim Ressler, Founder and CEO of SNiP Nutrigenomics, to explore the growing world of DNA-personalized nutrition. Kim shares how her own search for answers led her away from one-size-fits-all wellness protocols and toward understanding her individual genetic blueprint. Linda and Kim discuss how genetics may influence nutrition and supplementation, the difference between what bloodwork and DNA can tell us, why genes are not necessarily destiny, and how women can stop chasing every new diet, supplement, wearable, and biohacking trend. They also explore what personalized nutrition could mean for women navigating midlife, changing hormones, performance, and longevity. In this episode, you'll learn: • Why one-size-fits-all wellness can fall short • What nutrigenomics actually means • What DNA can and cannot tell you about nutrition • The difference between genetic information and bloodwork • How genetics may help personalize supplementation • Why genetic predisposition does not automatically equal destiny • The potential role of DNA in women's health and longevity • Why expensive biohacks shouldn't replace foundational health habits • How SNiP Nutrigenomics is working to make personalized nutrition more accessible Connect with Kim Ressler: SNiP Nutrigenomics snipnutrition.com Use Discount Code SOS 50 for $50 off  Summary In this episode, Kim Russler, founder and CEO of SNP Neutrogenomics, shares how personalized genetic insights can revolutionize nutrition and wellness. Discover how understanding your DNA can help tailor your diet, supplements, and lifestyle for optimal health and longevity.  Key  Topics The role of genetics in personalized nutrition How DNA testing can identify nutrient needs and deficiencies The impact of genetic markers on health conditions like autoimmune and inflammation The importance of foundational health and targeted support Future trends in precision medicine and wellness  Takeaways Understanding your genetics can help tailor your diet and supplements more effectively. DNA testing can reveal specific pathways like methylation and detox that impact health. Personalized nutrition supports better immune function and longevity. Genetics can explain why certain diets or supplements work for some but not others. Supporting genetic pathways with targeted nutrients can improve overall well-being.  Sound Bites "Folic acid impacts inflammation and detox pathways" "Genes work like a symphony, supporting each other" "Stop guesswork, support your body in a personalized way" Chapters 00:00 Introduction to Kim Russler and SNP Neutrogenomics 01:56 Kim's personal health journey and discovery of genetic testing 05:05 Understanding the role of genetics in nutrition and health 08:52 How genetic markers influence supplement needs and diet 13:04 The importance of foundational health and lifestyle choices 16:57 Genetics and aging: menopause, hormones, and longevity 21:11 How SNP Neutrogenomics personalizes health support 24:59 The future of personalized medicine and wellness 29:06 Kim's vision for accessible genetic health solutions 32:52 Final thoughts: empowerment through genetic understanding

Have you heard about the radioactive wolves in Chernobyl? Or the latest gene-editing tech that's curing rare diseases? Or that male birth control might be on the horizon? No?!Well, get ready, because while we've been busy living our lives, genomics has been moving – fast! Things that once read like science fiction are moving on over to the non-fiction section.This season on Nice Genes!, join Dr. Kaylee Byers as she engages in some big genomics breakthroughs – from personalized cancer treatments, to how our bodies react in space, to how animals adapt to the most extreme environments, and whether we can actually change how we age.It's a whole new gene-eration (if you will) of discoveries that you won't want to miss!New episodes every two weeks, starting September 8th. Make sure you follow Nice Genes! so you don't miss an episode!

Let's talk about how much of our health is actually determined by our genetics?Access the Mindful Eating & Healthy Living Course here:https://yourlifenutrition.org/course/Schedule a FREE Discovery Call with me here:https://yourlifenutrition.org/nutrition-coaching-application/.Come join our private accountability group, the Goal Getters Group, for all things health, wellness & nutrition! You'll get sample weekly meal plans, recipes, weekly group coaching calls and access to our exclusive Blood Sugar, Wellness, Mindfulness & Movement Challenges to help support you and keep you accountable on your health & nutrition journey AND get access to private messaging with me, your dietitian!Click the link below to join the Goal Getters Group today!https://your-life-nutrition-goal-getters.mn.co/plans/1821314?bundle_token=1724009ab3ed355237fdeeebd2fe1d9f&utm_source=manual.For health & nutrition tips, recipes & more - follow me on:Instagram: https://www.instagram.com/yourlifenutrition/Facebook: https://www.facebook.com/yourlifenutritionrdn/Email: Brittany@yourlifenutrition.orgShop my Favorite Products!Stelo Continuous Glucose Monitor System**I am an Amazon Affiliate and may earn commissions on qualifying purchases.

What if your genes aren't controlling your destiny nearly as much as you've been taught to believe? And what if many of the patterns shaping your health, relationships, behavior, and perception of the world were programmed into you before you were even consciously aware of them? In this powerful conversation, Darin sits down with stem cell biologist and bestselling author Dr. Bruce Lipton to explore his theories around epigenetics, subconscious programming, consciousness, stress, evolution, and the mind-body connection. Bruce also opens up about his experience with tongue cancer and how it forced him to confront the very ideas about biology and belief that he had spent decades teaching. Together, they explore Bruce's claim that we spend as much as 95% of our lives operating through subconscious programs, many of which were downloaded during early childhood. Bruce explains why he believes our perception of the environment influences biology, why taking responsibility for unconscious patterns is essential to reclaiming personal power, and how those programs can be rewritten. The conversation expands beyond individual health into humanity itself, challenging the cultural story of "survival of the fittest" and exploring cooperation, community, consciousness, spirituality, environmental collapse, and why Bruce believes the upheaval we're experiencing may actually represent an evolutionary turning point. What You'll Learn How Bruce's experience with tongue cancer challenged him to apply his own teachings Why Bruce believes subconscious programming controls much of our everyday behavior How childhood experiences may become unconscious programs that follow us into adulthood Why falling in love can temporarily interrupt subconscious programming Bruce's explanation of epigenetics and why he rejects genetic determinism Why taking responsibility for your unconscious patterns can help you reclaim your power How stress, belief, and perception interact within Bruce's model of health and disease Why Bruce challenges the cultural interpretation of "survival of the fittest" How cooperation, community, and harmony fit into his theory of human evolution Why Bruce believes changing collective consciousness begins with individuals living differently Chapters 00:00:03 – Welcome to SuperLife 00:00:34 – Sponsor: Miko Dog 00:02:00 – Introducing Dr. Bruce Lipton 00:03:33 – Bruce's personal experience with tongue cancer 00:04:21 – Why his diagnosis brought decades of research to the forefront 00:05:23 – Bruce's belief that cancer is a symptom, not the underlying problem 00:06:23 – Why Bruce believes this message matters right now 00:07:25 – The biological imperative and humanity's drive to survive 00:08:22 – You are not a victim of your genetics 00:10:15 – Are 95% of our lives controlled by subconscious programming? 00:11:13 – How your subconscious takes over when you're thinking 00:12:46 – Why Bruce calls The Matrix a documentary 00:13:04 – Falling in love and escaping subconscious programming 00:14:27 – How to stay in the "honeymoon effect" 00:15:20 – Why the brain functions like a programmable computer 00:16:12 – The first seven years and the theta state 00:17:09 – How children download behavior from parents and community 00:18:08 – Bruce's childhood programming and failed relationships 00:18:39 – Rewriting his programming and finding lasting love 00:19:11 – Are you living your life or living your program? 00:20:11 – Your life as a reflection of subconscious beliefs 00:21:09 – Sponsor: Bite 00:23:24 – Why working harder doesn't necessarily change the program 00:23:55 – Bruce's claims about programming, stress, and disease 00:25:25 – Money, career, relationships, and the programs underneath them 00:26:18 – Why blaming others keeps you powerless 00:27:14 – Taking 100% responsibility for your life 00:28:18 – Hard experiences as opportunities to reorient your life 00:29:19 – Why victimhood means giving away your power 00:29:54 – How childhood can program our relationship with doctors and healing 00:31:14 – How beliefs can shape our perception of reality 00:32:04 – The centuries-old understanding of childhood programming 00:33:03 – How modern technology intensifies programming 00:34:03 – Challenging genetic determinism 00:34:31 – Genes as blueprints and the mind as architect 00:35:03 – Bruce's explanation of epigenetics 00:35:40 – Why Bruce compares the cell membrane to a computer chip 00:37:08 – Taking your power back 00:37:32 – How consumer culture programs desire 00:39:15 – Cooperation versus Darwinian competition 00:39:49 – When did life become a struggle? 00:41:28 – Rethinking "survival of the fittest" 00:42:30 – Resources, consumption, and the planetary pie 00:44:05 – Corporations and the economics of competition 00:45:46 – Environmental instability and the threat to our food system 00:47:43 – Why Bruce sees today's crisis as an evolutionary upheaval 00:48:15 – Moving beyond the belief that more is always better 00:49:11 – Bruce's theory about humans absorbing energy from the environment 00:50:18 – Food, free radicals, aging, and longevity 00:51:17 – Eating less, fasting, and longevity 00:52:09 – Why Darin still sees hope 00:53:16 – The garden isn't a battleground 00:53:51 – Cooperation, harmony, and our relationship with nature 00:55:21 – Indigenous wisdom and humanity's role as gardeners 00:57:03 – Life as creation instead of struggle 00:58:01 – How Bruce's study of immunology changed his spiritual worldview 00:59:09 – Cell receptors, identity, and Bruce's theory of the "field" 01:00:19 – The television and broadcast analogy for consciousness 01:01:22 – Bruce's interpretation of reincarnation 01:01:48 – Looking beyond race, gender, religion, and nationality 01:02:25 – Why Bruce believes we're here to manifest 01:03:20 – Creating heaven on Earth 01:04:43 – Bruce's claims about disease, genetics, stress, and programming 01:05:44 – Changing the program while the world is in chaos 01:06:34 – Darin's vision of communities that actually work 01:07:31 – Choosing where you put your focus 01:08:22 – Life is a gift, not a struggle 01:09:55 – Why Bruce believes knowledge is power 01:11:51 – Darin opens up about losing his mother 01:13:00 – Energy, grief, and nonverbal communication 01:14:10 – The power to create a different future 01:14:57 – Can a clear vision override subconscious programming? 01:15:35 – Bruce's interpretation of thoughts as an energy field 01:17:05 – How individual consciousness becomes collective consciousness 01:17:34 – Why community amplifies change 01:18:36 – Coherence versus the noise of the world 01:19:05 – Why you can't force someone else to change 01:19:59 – How many people does it take to shift collective consciousness? 01:21:04 – One candle can light up a dark room 01:22:05 – Why Bruce believes humanity is at an evolutionary turning point 01:22:39 – Surviving and thriving through massive change 01:23:23 – Surrounding yourself with people in harmony 01:24:04 – Community, gratitude, and final thoughts 01:24:36 – Closing Thank You to Our Sponsors: Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order. Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout. Join the SuperLife Community: Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien Find More from Bruce Lipton: Website: brucelipton.com Instagram: @brucelipton Buy His New Book: Beyond Darwin Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "You have to take your power back. Much of what shapes your life may be operating beneath conscious awareness, but Bruce's central message is that those patterns don't have to remain permanent. By becoming aware of the programs you're running, taking responsibility for what you're creating, and consciously choosing the beliefs, relationships, communities, and vision you want to reinforce, you can begin creating a life based less on fear and struggle and more on love, cooperation, and possibility."

Our dear friends invited us to an event this weekend in LA… they are partnering with Gary Brecka to build Ultimate Longevity Centers which will bring treatments and testing that just hasn't been easily accessible before now. I believe the way we look at aging is outdated and I'm going to share the biggest take aways I got from his on stage message and chatting with him one on one. We are talking about very practical starting points and Gary Brecka's actual morning health routine. Stop waiting until something is wrong to start taking care of your body. We have been taught this idea that getting older automatically means getting weaker, having less energy, gaining weight, losing muscle, sleeping worse, becoming more anxious, needing more medications and eventually developing all of the diseases that "run in our family." Gary challenges a lot of that thinking. His message is essentially… What if we became obsessed with keeping our bodies functioning incredibly well for as long as possible? What if instead of asking, "How do I treat disease once I have it?" we asked, "How do I create a body that is incredibly difficult for disease to thrive in?" And then there's the longevity piece that completely fascinates me. Gary believes we're entering a period where medicine, AI, biological data and longevity research are going to advance so rapidly that lifespan could look radically different in the future. Maybe 120. Maybe beyond. We don't know. But what we do know is that we need to keep ourselves healthy enough NOW to benefit from whatever becomes possible later. So today's episode is about doing the things that give you the strongest, healthiest, most capable body possible. I've been listening to Gary Brecka talk about health, longevity, anxiety, genetics, sleep, sunlight, oxygen, muscle, bloodwork and what he believes is coming next in longevity science. THE BIG IDEA: YOUR HEALTH IS BUILT EVERY DAY One of my biggest takeaways from Gary is that health isn't something we deal with when there's a problem. It's something we're building every single day. Your sleep last night matters. What you do when you wake up matters. Whether you move your body matters. Whether you maintain muscle matters. Your metabolic health matters. Your stress matters. Your relationships matter. Your nutrition matters. Your environment matters. And individually, none of these things feels life-changing. But repeated for years and decades… they become your life. Gary describes his routine as simple, portable and repeatable. I LOVE that. Because the best health routine isn't the $100,000 biohacking setup. It's the one you'll actually do every day. HABIT #1: HYDRATE BEFORE YOU DO ANYTHING ELSE Gary starts his morning with water and minerals. One version of his routine is a large glass of room-temperature water with mineral salt and sometimes lemon. His current routine also frequently includes mineral salt, hydrogen water and essential amino acids. Wake up and hydrate. You've just spent roughly eight hours without drinking anything. Don't make coffee your first liquid of the day. Put water next to your bathroom sink. Put it next to your coffee machine. Make it automatic. Gary likes mineral salt because sodium and other minerals participate in fluid balance and normal nerve and muscle function. HABIT #2: GET OUTSIDE FIRST THING Gary says to get outside within the first part of your morning and get natural outdoor light into your eyes. His routine generally calls for about 10 minutes outside. Morning light helps tell your brain: It's daytime. Start the clock. Light is one of the strongest environmental signals for the circadian system. Properly timed morning light can shift circadian timing earlier and increase daytime alertness. And I love thinking of sleep this way: Your good night's sleep starts in the morning. We tend to think sleep health starts when we crawl into bed. But your body has been receiving signals all day telling it when to be awake and when to prepare for sleep. HABIT #3: BREATHE ON PURPOSE Gary talks about oxygen constantly. His personal morning practice has included three rounds of deep breathing followed by breath holds. And this connects to another thing we've been talking about: Anxiety. I love the idea that when you feel anxious, you shouldn't immediately decide: "I'm an anxious person." Anxiety is a state your nervous system is experiencing. Sometimes your thoughts are driving your physiology. And sometimes your physiology can amplify anxious thoughts. Either way, changing the physical state can sometimes help change the mental state. Research on structured breathwork has found modest improvements in stress and anxiety, although it isn't a cure-all and the quality of studies varies. HABIT #4: GIVE YOUR BRAIN SILENCE Gary often combines his morning breathing with quiet, gratitude and reflection. He has described sitting quietly for around 10 minutes, looking toward the horizon or closing his eyes and thinking about gratitude. (PodScripts (https://podscripts.co/podcasts/the-ultimate-human-with-gary-brecka/246-gary-brecka-answers-googles-most-searched-questions-on-his-diet-wellness-and-lifestyle?utm_source=chatgpt.com)) Think about how different this is from what most of us do. Eyes open. Phone. Email. Instagram. News. Text messages. Stress. Other people's priorities. And we wonder why we feel overstimulated. TRY THIS: Before consuming everybody else's thoughts… Have some of your own. What am I grateful for? What matters today? Who needs me today? How do I want to feel today? What is actually important? PRACTICAL VERSION: Five minutes. That's it. No phone. No podcast. No input. Just quiet. HABIT #5: USE CONTROLLED DISCOMFORT Cold exposure is another major Brecka habit. If he has access to a cold plunge, he uses it. When traveling, he has said a cold shower works too. But I think there is a bigger lesson here than whether everybody needs to buy a cold plunge. Stop designing your entire life around comfort. Human beings are unbelievably adaptable. Exercise is stress. Heat is stress. Cold is stress. Fasting is stress. Challenging your brain is stress. The key is appropriate amounts of stress followed by recovery. HABIT #6: MOVE EARLY Gary includes movement in his morning routine. But here's what I love: It doesn't need to be a full workout. Walk. Stretch. Squat. Lift. Do yoga. Go outside. Movement tells your body: We're alive. We're using this machine today. And then keep moving after the morning is over. One exceptionally practical habit is walking after meals. Instead of finishing dinner and immediately sitting on the couch… WALK FOR 10 MINUTES. Moving skeletal muscle after eating can help the body handle glucose. You don't need workout clothes. You don't need a gym. You don't even need to sweat. Walk around your neighborhood. Walk your dog. Walk while you're on a phone call. ONE OF THE EASIEST HEALTH RULES: Eat → walk. HABIT #7: BUILD MUSCLE LIKE YOUR FUTURE DEPENDS ON IT This is where I think longevity conversations get really practical. MUSCLE IS NOT JUST ABOUT LOOKING GOOD. Maintaining muscle becomes increasingly important as we age. Resistance training is one of the most powerful non-drug strategies available for preserving and building skeletal muscle. Losing muscle eventually affects: strength balance mobility independence your ability to recover from illness your ability to do normal life You're not building your 2026 body. You're building your 2056 body. HABIT #8: PRIORITIZE PROTEIN AND REAL FOOD- avoid processed foods Gary emphasizes protein and essential amino acids because preserving lean tissue is a major part of his longevity philosophy. The research strongly supports resistance training for preserving muscle, while evidence regarding how much additional benefit comes from protein supplementation specifically is more mixed. HABIT #9: PROTECT YOUR METABOLIC HEALTH I think this deserves WAY more attention. We obsess over weight. Gary talks much more about metabolic health. There is a difference. Weight is one number. Metabolic health includes things like: blood glucose insulin sensitivity blood pressure blood lipids waist circumference fitness body composition Instead of only asking: "How much do I weigh?" Ask: "How well is my body functioning?" Someone can lose weight while losing muscle. Someone can be thin and still have poor metabolic health. PRACTICAL HABITS: Strength train. Walk. Walk after meals. Eat mostly whole foods. Get enough sleep. Maintain healthy body composition. Reduce constant snacking if it isn't serving you. Know your basic health numbers. THE GOAL ISN'T SKINNY. The goal is metabolically capable. HABIT #10: TEST… DON'T JUST GUESS This might be one of my favorite parts of Brecka's philosophy. Stop guessing about everything. If you're exhausted all the time… investigate. If you're unusually anxious… investigate. If your sleep has suddenly changed… investigate. If your energy has disappeared… investigate. If your hormones feel completely different… investigate. If you feel awful despite doing "everything right"… investigate. Don't immediately decide: "I'm getting old." "This runs in my family." "I'm just an anxious person." "My metabolism sucks." "This is just how I am." ASK BETTER QUESTIONS. Could something modifiable be contributing? sleep nutrient deficiencies thyroid function iron status medications hormones metabolic health stress alcohol caffeine environment psychological health This does NOT mean ordering every exotic test on the internet. It means becoming curious about your own biology. HABIT #11: DON'T TURN ANXIETY INTO YOUR IDENTITY This is worth repeating because I think this is such an important mental shift. Instead of: "I AM anxious." Try: "I'm experiencing anxiety." Those are very different statements. One is an identity. One is a temporary condition worth investigating. Gary's message leans heavily toward investigating biology. He talks about things like methylation pathways and MTHFR. There are legitimate genetic influences on anxiety. But anxiety is complex. Research suggests anxiety disorders arise through a combination of genetic vulnerability and environmental influences, not one single "anxiety gene." (PubMed (https://pubmed.ncbi.nlm.nih.gov/15699295/?utm_source=chatgpt.com)) So I would approach it from ALL DIRECTIONS: Calm the body. Investigate the biology. Work on the thoughts. Breathwork. Sleep. Exercise. Less overstimulation. Healthy relationships. Therapy when needed. Medical evaluation when something feels physiologically off. Nutrition. Less caffeine when appropriate. Time outdoors. Don't choose between: "It's psychological." or "It's biological." It can be both. HABIT #12: GENETICS ARE INFORMATION… NOT ALWAYS DESTINY This is another Gary Brecka concept that I think is incredibly empowering when we phrase it accurately. People say: "Diabetes runs in my family." "Anxiety runs in my family." "Heart disease runs in my family." "Autoimmune disease runs in my family." And we can start thinking: Well… I guess that's coming for me too. But genetics often represent susceptibility rather than certainty. Your genes can increase risk. Your environment can increase or decrease risk. Your behaviors matter. Your metabolic health matters. Your exposures matter. Your entire biological environment matters. So instead of thinking: "My family gets this disease." Think: "I may have inherited a vulnerability. What parts of that vulnerability can I modify?" THAT is empowering. Important distinction: Some diseases absolutely are caused by inherited genetic mutations. So we should not say: "Genetic diseases aren't real." They absolutely are. The better message is: Genes can load the gun. They don't always pull the trigger. And with many complex chronic diseases, what ultimately happens involves an interaction between genetics and environment. HABIT #13: STOP THINKING OF SLEEP AS LOST PRODUCTIVITY Sleep is when your body gets to repair. And Brecka's evening routine reflects this. He emphasizes regular sleep, reducing stimulation late at night and setting up the next morning by protecting the night before. My favorite way to think about sleep: Tomorrow starts tonight. Stop trying to squeeze another hour out of your day if it destroys tomorrow. Decide when you're going to bed BEFORE you're tired. Dim things down. Get off your phone. Stop working. Let the nervous system receive a signal that the day is ending. Pick a bedtime and protect it the same way you'd protect an important meeting. NOW LET'S TALK ABOUT LIVING TO 120 The speed of advancement is changing. AI can analyze enormous amounts of biological data. Diagnostics are improving. Scientists are studying the actual biology of aging rather than treating aging purely as an unavoidable decline. Researchers are investigating cellular senescence, epigenetics, regenerative medicine and other mechanisms associated with biological aging. Gary believes these developments could eventually change human lifespan dramatically. And his argument is essentially: Stay alive and stay healthy long enough to benefit from what's coming. That hit me HARD. Because imagine being 75 in the future… But instead of arriving at 75: metabolically sick weak frail sedentary cognitively struggling carrying multiple preventable chronic illnesses You arrive: strong metabolically healthy active engaged cognitively sharp sleeping well maintaining muscle surrounded by people you love THAT is the bridge. Not: "How do I live forever today?" But: "How healthy can I be when tomorrow's medicine arrives?" DON'T JUST CHASE LIFESPAN. CHASE HEALTHSPAN. I don't want to simply exist until I'm 120. I want to LIVE. I want to: travel walk everywhere lift my suitcase play with grandchildren hike swim think clearly learn new things have great conversations have energy be independent laugh have purpose wake up excited THAT is longevity. Not adding years at the end where you can't live. Adding life to the years. WHAT SHOULD WE ACTUALLY DO RIGHT NOW? If you took this entire episode and boiled it down into a daily longevity checklist… MORNING Hydrate. Get outside. Get natural morning light. Breathe intentionally. Spend a few minutes in quiet. Think about gratitude. Move your body. Use cold exposure if you enjoy it and it's appropriate for you. Don't immediately flood your brain with stress. DURING THE DAY Eat nutrient-dense real food. Prioritize protein. Strength train consistently. Walk. Walk after meals. Stay metabolically healthy. Maintain muscle. Build meaningful relationships. Have purpose. Keep learning. Get outside. NIGHT Stop eating mindlessly late into the evening. Reduce stimulation. Get off the phone. Give yourself a predictable bedtime. Sleep. THROUGHOUT YOUR LIFE Know your numbers. Do appropriate preventive screening. Investigate symptoms rather than ignoring them. Don't automatically assume something is "just aging." Don't automatically assume family history means destiny. Continue learning as science changes. Protect your muscle. Protect your metabolism. Protect your brain. Protect your relationships. Protect your sleep. THE SIMPLEST VERSION OF EVERYTHING GARY BRECKA IS SAYING 1. Get sunlight. 2. Breathe. 3. Hydrate. 4. Move. 5. Build muscle. 6. Eat real nutrient-dense food. 7. Protect your metabolism. 8. Sleep like it matters. 9. Challenge your body sometimes. 10. Investigate problems instead of simply accepting them. 11. Don't confuse genetic risk with guaranteed destiny. 12. Don't turn anxiety into your identity. 13. Build relationships and a life that gives you purpose. 14. Stay unbelievably healthy while longevity science continues advancing. And maybe most importantly… DON'T WAIT UNTIL YOU'RE SICK TO BECOME INTERESTED IN YOUR HEALTH. I learned that every single thing that gives me the best chance of being healthy at 120 also gives me a better life at 45. Getting sunlight tomorrow morning makes tomorrow better. Sleeping tonight makes tomorrow better. Building muscle makes this decade better. Eating well makes today better. Getting outside makes today better. Putting my phone down makes today better. Managing anxiety makes today better. Having people I love around me makes today better. So this isn't really an episode about trying to cheat death. It's about refusing to sleepwalk through your health. Your body is the vehicle that carries you through every single experience you're hoping to have. Every trip. Every adventure. Every business idea. Every dinner. Every workout. Every moment with your kids. Every future grandkid. Everything. So take ridiculously good care of it. And instead of looking at aging and thinking… "Well, I guess everything starts going downhill from here…" What if we thought completely differently? What if our goal was: I want to be stronger next year. Healthier next year. More metabolically healthy next year. More informed next year. More capable next year. And then do it again. And again. And again. For decades. Let's make the goal to be fully alive for as much of it as humanly possible. That's the health lesson I'm taking from Gary Brecka. Don't wait for the future of longevity medicine. Build the kind of body today that's ready for it.

Methylation is a chemical process running billions of times per second inside your body — and when it slows down, you feel it as fatigue, low mood, brain fog, and hormone symptoms. Nurse Doza breaks down what methylation actually does, why the MTHFR gene variant makes the cycle run less efficiently, why folic acid is the wrong form of folate if you carry it, and the four steps that support your methyl donor supply. FEATURED PRODUCT Bliss (Mood Booster) — $129 Bliss is a lemon-flavored daily stick pack built around TMG (trimethylglycine) — a naturally occurring methyl donor. It is formulated to support the biochemical reactions that require methyl groups: neurotransmitter synthesis and healthy mood, the conversion of homocysteine to glutathione, and liver health.* If the episode described you — normal labs, still running on empty — Bliss is the piece that feeds the cycle directly instead of asking your genetics to do the conversion work.

In this episode I sit down with epigenetic longevity strategist Chris Barnes to explore how our genes influence our health, and why our genetics don't necessarily determine our future.Together, we unpack the science of epigenetics, how everyday choices like sleep, nutrition, movement and stress can influence gene expression, and why a personalised approach to health may be more effective than blindly following the latest diet, supplement or longevity trend.What we cover:What epigenetics is and how your lifestyle can influence gene expressionWhy your genetics aren't necessarily your health destinyHow genetic and epigenetic testing can help personalise your approach to healthWhy more supplements, biohacking and health data aren't always betterThe simple daily habits Chris believes can support long-term health and longevityWhether you're focused on high performance, longevity or simply having more energy for the people and things that matter most, this conversation is a fascinating look at why understanding your individual biology could help you make better decisions about your health.Learn more about Chris here - https://chrisbarneswellness.com.au/about-wellness-programs/Follow Chris on IG - https://www.instagram.com/chrisbarneswellness/Connect with Chris on LinkedIn - https://www.linkedin.com/in/chris-barnes-wellness/If you're interested in having me deliver a keynote or workshop for your team contact Caroline at caroline@jjlaughlin.comWebsite: https://www.jjlaughlin.com YouTube: https://www.youtube.com/channel/UC6GETJbxpgulYcYc6QAKLHA Facebook: https://www.facebook.com/JamesLaughlinOfficial Instagram: https://www.instagram.com/jameslaughlinofficial/ Apple Podcast: https://podcasts.apple.com/nz/podcast/life-on-purpose-with-james-laughlin/id1547874035 Spotify: https://open.spotify.com/show/3WBElxcvhCHtJWBac3nOlF?si=hotcGzHVRACeAx4GvybVOQ LinkedIn: https://www.linkedin.com/in/jameslaughlincoaching/James Laughlin is a High Performance Leadership Coach, Former 7-Time World Champion, Host of the Habits of High Performers Podcast and an Executive Coach to high performers and leaders. James is based in Christchurch, New Zealand.Send me a personal text message - If you're interested in booking me for a keynote or workshop, contact Caroline at caroline@jjlaughlin.comSupport the show

El presidente del CTA analiza en 'Carrusel' las novedades del arbitraje español, el VAR y la inteligencia artificial

El presidente del CTA analiza en 'Carrusel' las novedades del arbitraje español, el VAR y la inteligencia artificial

A 2025 study found that exposure to certain PFAS chemicals, which are pervasive and persistent in the environment and human bodies, can lead to changes in gene expression that are linked to cancers, autoimmune and other immune disorders, and neurological disorders.    Also, the four astronauts of the Artemis II mission in April 2026 made new scientific observations that are helping to expand our knowledge of the Moon, as well as the Earth itself. Artemis II Lunar Science Lead Kelsey Young joins us to talk about the scientific goals and accomplishments of the mission and the unforgettable moments the crew shared with people back on Earth.   And climate solutions like renewable energy tech that requires intensive mining can run into skepticism from people across the political spectrum. But according to data scientist Hannah Ritchie, many of the concerns are based on partial- and misinformation, and the outlook for addressing the climate emergency isn't as grim as some people may think. Ritchie is the author of Clearing the Air: A Hopeful Guide to Solving Climate Change in 50 Questions and Answers.    ---  You can help support our free public radio show and podcast, for free, by leaving a review on Apple Podcasts. It's one of the best ways to help other listeners find Living on Earth!  Learn more about your ad choices. Visit megaphone.fm/adchoices

Sergio Pérez entrevista en San Sebastián al director islandés por esta película que empezó a rodar en 2027. Nos cuenta su peculiar forma de trabajar:

What if food is doing far more than providing calories, protein, carbohydrates, and fat? What if every bite is actually delivering information to your genes, cells, microbiome, and biological systems? In this fascinating solo episode, Darin challenges the century-old idea of viewing food simply as fuel and explores what happens when we begin seeing food as biological information. From carrots resembling eyes and walnuts resembling brains to nutrigenomics, plant compounds, biophotons, structured water, living enzymes, and the microbiome, Darin dives into the hidden layers of food that never appear on a nutrition label. He explores established research alongside emerging and controversial areas of science, explaining why the freshness, color, diversity, and wholeness of what we eat may matter far beyond its calorie count. Darin also reveals why "eating the rainbow" is really about consuming a wider library of chemical information and why feeding your gut microbes may be just as important as feeding yourself. This episode will completely change the way you look at what's sitting on your plate. What You'll Learn Why Darin believes the calorie model leaves out some of food's most important biological effects How nutrients and plant compounds can influence gene expression through nutrigenomics and epigenetics Why Darin describes every meal as sending a "memo" to your DNA What biophotons are and the emerging research around light emitted by living cells and foods Why fresh, living foods may carry information that heavily processed foods have lost The theory of structured or "exclusion zone" water in living foods What happens to naturally occurring enzymes when foods are heated and processed Why the colors of fruits and vegetables correspond to different families of protective plant compounds How your food communicates with the trillions of microbes living inside your gut Why dietary diversity and fermented foods may help create a healthier, more resilient microbiome Chapters 00:00:00 – Welcome to SuperLife 00:00:32 – Sponsor: Bite 00:02:47 – The hidden clues sitting inside your food 00:03:22 – Carrots, tomatoes, and walnuts: coincidence or clues? 00:04:13 – Why we've been too busy counting calories 00:04:39 – Food is information 00:04:47 – Why the calorie model leaves out the bigger picture 00:05:14 – Your body isn't a furnace 00:05:48 – How food communicates with your cells 00:06:25 – Nutrigenomics: how food talks to your genes 00:06:53 – Every meal can influence gene expression 00:07:22 – What memo are you sending your DNA? 00:07:52 – The strange science of biophotons 00:09:03 – Why fresh food emits different light than processed food 00:09:37 – Where biophoton research stands scientifically 00:10:26 – Structured water and the fourth phase of water 00:12:00 – What processing may do to water inside food 00:12:37 – Sponsor: Manna Vitality 00:14:35 – The controversial theory of food enzymes 00:15:18 – What we know about enzymes in raw and sprouted foods 00:15:37 – The hidden information missing from nutrition labels 00:15:58 – Can the color of your food unlock your potential? 00:16:16 – Why "eat the rainbow" is chemistry, not mysticism 00:16:38 – Anthocyanins and the power of purple, red, and blue foods 00:17:27 – Color is the plant's natural label 00:18:20 – Every color sends your body a different message 00:18:50 – The problem with the modern "beige diet" 00:19:14 – You're feeding 38 trillion microbes, not just yourself 00:19:46 – How gut bacteria transform fiber into powerful compounds 00:20:25 – The extraordinary conversation between plants and your microbiome 00:21:05 – Why plant diversity matters for immunity, mood, and hormones 00:21:31 – The Stanford fermented food study 00:22:02 – What fermented foods did to microbiome diversity and inflammation 00:22:30 – Ultra-processed food, inflammation, and what's coming next 00:22:45 – Continue the full deep dive on Patreon 00:23:24 – Closing thoughts Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "Food isn't just fuel. Every bite carries information—through nutrients, plant compounds, color, fiber, enzymes, and the interactions it creates with your microbiome. Your body isn't simply counting calories; it's responding to biological signals. So the question isn't only how much you're eating. It's what message you're sending your body every time you sit down to eat." Bibliography/Sources: Food as Information & Nutrigenomics Dutton, R. (2017). Hey, Hippocrates: Food isn't medicine. It's just food. STAT News . https://www.statnews.com/2017/04/10/hippocrates-food-medicine/ Genes and diet in the prevention of chronic diseases in future generations. (n.d.). PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC8900696/ Müller, M., et al. (2026). Nutrigenomics and the interface between diet and gene expression. ScienceDirect . https://www.sciencedirect.com/ Nutriepigenomics. (n.d.). In Wikipedia . https://en.wikipedia.org/wiki/Nutriepigenomics Stover, P. J., & Garza, C. (n.d.). Food as exposure: Nutritional epigenetics and the new metabolism. PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC6486241/ Biophotons & Structured Water Bio-photons: The light in your cells, food & water. (n.d.). Watermatters . https://www.yourwatermatters.com/ Biophotons may shed new light on body and brain activity. (2025). Psychology Today . https://www.psychologytoday.com/ Pollack Laboratory. (n.d.). University of Washington. https://pollacklab.org/ Pollack, G. H. (2013). The fourth phase of water: Beyond solid, liquid, and vapor. Ebner & Sons Publishers . The legacy of light: Fritz-Albert Popp and the biomedical power of biophotons. (n.d.). Dr. Clark Store . https://drclarkstore.com/ Enzymes, Sprouting & Traditional Diets Characteristics of traditional diets. (n.d.). The Weston A. Price Foundation . https://www.westonaprice.org/ Edward Howell, MD. (n.d.). The Weston A. Price Foundation . https://www.westonaprice.org/ Germination: An alternative source to promote phytonutrients in edible seeds. (n.d.). Food Quality and Safety . https://academic.oup.com/fqs Howell, E. (1985). Enzyme nutrition: The food enzyme concept. Avery . Nutritional and end-use perspectives of sprouted grains: A comprehensive review. (2021). Food Science & Nutrition . https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.2477 Price, W. A. (1939). Nutrition and physical degeneration. Price-Pottenger Nutrition Foundation . Study on effect of germination on flavonoid content and nutritional value of different varieties of chickpeas. (2024). PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC10787121/ Phytonutrients & Colors Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits. (2017). Food & Nutrition Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC5613902/ Anthocyanins as key phytochemicals acting for the prevention of metabolic diseases. (n.d.). PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC6489379/ The therapeutic potential of anthocyanins: Current approaches based on their molecular mechanism of action. (2020). Frontiers in Pharmacology . https://www.frontiersin.org/articles/10.3389/fphar.2020.01300/full Microbiome, Fiber & Fermented Foods From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. (2016). Cell . https://www.cell.com/cell/fulltext/S0092-8674(16)30559-6 Stanford Medicine. (2021, July). Fermented-food diet increases microbiome diversity, decreases inflammatory proteins, study finds . https://med.stanford.edu/news/all-news/2021/07/fermented-food-diet-increases-microbiome-diversity-lowers-inflammation The mutual effect of dietary fiber and polyphenol on gut microbiota. (2025). ScienceDirect . https://www.sciencedirect.com/ Shape, Biomimicry & Botanical History Cardenas, D. (2013). Let not thy food be confused with thy medicine: The Hippocratic misquotation. e-SPEN Journal . https://doi.org/10.1016/j.clnme.2013.10.002 How do the 'three sister' plants work together? (n.d.). Soils Matter . https://soilsmatter.wordpress.com/ Kimmerer, R. W. (2013). Braiding sweetgrass: Indigenous wisdom, scientific knowledge, and the teachings of plants. Milkweed Editions . Nutritional benefits of lycopene and beta-carotene: A comprehensive overview. (n.d.). PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC9317578/ The six tastes in Ayurveda: How rasa creates true satisfaction. (n.d.). Art of Living Retreat Center . https://artoflivingretreatcenter.org/ Three sisters farming: A model of regenerative agriculture. (n.d.). One Earth . https://www.oneearth.org/ Ultra-Processed Food & Meat Research Cleveland Clinic. (2018). Cleveland Clinic studies reveal role of red meat in gut bacteria, heart disease development . https://newsroom.clevelandclinic.org/ Hall, K. D., et al. (2019). Ultra-processed diets cause excess calorie intake and weight gain: An inpatient randomized controlled trial of ad libitum food intake. Cell Metabolism . https://doi.org/10.1016/j.cmet.2019.05.008 Harvard T.H. Chan School of Public Health. (2015). WHO report says eating processed meat is carcinogenic . https://www.hsph.harvard.edu/nutritionsource/2015/11/03/report-says-eating-processed-meat-is-carcinogenic-understanding-the-findings/ International Agency for Research on Cancer. (2015, October). Carcinogenicity of the consumption of red meat and processed meat. IARC Monographs Volume 114 . https://publications.iarc.fr/ The detrimental impact of ultra-processed foods on the human gut microbiome and gut barrier. (2025). Nutrients . https://www.mdpi.com/2072-6643/17/1 Ultra-processed foods and food additives in gut health and disease. (2024). Nature Reviews Gastroenterology & Hepatology . https://www.nature.com/articles/s41575-024-00898-3 Ultra-processed foods, gut microbiota, and inflammatory bowel disease: A critical review of emerging evidence. (2025). PubMed . https://pubmed.ncbi.nlm.nih.gov/

Hoy 13 de agosto es el Día Internacional de los Zurdos Esta fecha fue creada en 1976 por Dean R. Campbell, fundador de la organización americana Lefthanders International encargada de representar y defender los intereses de las personas zurdas. El objetivo de este día es dar a conocer los retos de usar la mano izquierda en un mundo creado para personas diestras. Se instauró como Día Internacional en 1992.

Anxiety in perimenopause isn't a mood problem — it's a clearance problem. Liz Roman and Becca Chilczenkowski break down COMT, GAD1 and FUT2: the three genes that decide how fast you clear adrenaline, whether you can build GABA, and whether your gut can grow the bacteria that make it. Plus why L-glutamine can make anxiety worse, why oral GABA mostly doesn't work, the lab markers hiding in plain sight on your standard panel, and why "your genes didn't change — your estrogen did." *** CONNECT:

Manny Maminakis is the inventor and CEO of Cannamatrix INC, a cannabis bioinfomratics platform. Prior to Cannamatrix, Manny spent 12 years in the cannabis industry as an award winning cannabis cultivator and edible chef. At CannMed 26, he presented a poster titled “Computational Identification of Volatile Sulfur Compound Synthase Homologs in Cannabis sativa Using Profile Hidden Markov Models” During our conversation, we discuss: What volatile sulfur compounds (VSCs) are and why they give certain cannabis strains their skunky, garlicky smell How Manny’s path from cannabis cultivator and award-winning edible chef led him into bioinformatics at Canimatrix Why the GMO (“garlic mushroom onion”) cultivar was chosen as the ideal candidate for studying VSCs How hidden Markov models were used to find candidate VSC genes by comparing cannabis proteins to garlic, onion, and other sulfur-producing plants And more! Thanks to This Episode’s Sponsor: Cannamatrix Cannamatrix is a genetic software company that empowers growers to select the best of the best from their seed stock. Their patented system of genetic testing with predictive algorithms helps growers harness the maximum potential of Cannabis while preserving the natural genetic makeup and reducing resource allocation, and saving time and money! Visit cannamatrix.com to learn more Related Resources @MannytheCannaBiologist on IG Review the Podcast CannMed Archive

El Año Nuevo ha estado marcado, en distintas culturas y épocas, por costumbres y rituales cargados de simbolismo.En este episodio de Interesante Historia exploramos el origen y significado de prácticas que buscan atraer la buena suerte, dejar atrás lo viejo y dar la bienvenida a nuevos comienzos, desde tradiciones ancestrales hasta hábitos que siguen vigentes hoy. En este final de temporada, haremos un recorrido breve y revelador por las creencias, gestos y ceremonias que acompañan una de las transiciones más importantes del calendario y que reflejan cómo las sociedades han intentado influir en el destino al iniciar un nuevo ciclo.¡Muchas gracias por acompañarme este 2025 y que el año que comienza sea el mejor para ustedes y sus seres queridos!Conviértete en un supporter de este podcast: https://www.spreaker.com/podcast/interesante-historia--5241488/support.

Bioweapons are cheaper and deadlier than nukes — and we're not ready. Biological War author Annie Jacobsen breaks down how close we are to catastrophe.Full show notes and resources can be found here: jordanharbinger.com/1367What We Discuss with Annie Jacobsen:The Soviet bioweapons program was not dismantled after the Cold War — it was absorbed. The State Department says Russia and North Korea run active illegal programs; China and Iran are of concern.Bioweapons have a low barrier to entry, needing no uranium or missiles. Experts say one could be made in a basement with basic biology and AI help. The Pentagon rates bio the greatest overall WMD threat.Pneumonic plague is 100% fatal without antibiotics within 24 hours. The US has roughly 100 special-pathogen beds for 340 million people, so hospitals would be overwhelmed on day one.Soviet scientists inserted a euphoria gene into plague so the infected feel good, stay social, and spread it widely instead of staying home in bed.Annie Jacobsen's message is pressure, not panic — a human-made problem has a human solution. Pause risky gain-of-function research, depoliticize the threat, and communicate clearly so leaders can act in time.And much more...And if you're still game to support us, please leave a review here — even one sentence helps! Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom!Do you even Reddit, bro? Join us at r/JordanHarbinger!This Episode Is Brought To You By Our Fine Sponsors: Article: Visit article.com/jordan for $50 off your first purchase of $100 or moreBetterHelp: 10% off first month: betterhelp.com/jordanBoll & Branch: 15% off first set of sheets: bollandbranch.com, code JORDANProgressive Insurance: Free online quote: progressive.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

SUSO33 nos habla del proceso de creación de 'El fluir de las imágenes', el mural que rayó en vivo, en 90 minutos como parte de la exposición 'Arte urbano. De los orígenes a Banksy' de la Fundación Canal. El artista ha sido reconocido este año con la Medalla al Mérito en las Bellas Artes.Xaviera Torres nos habla del interés que han generado los eclipses a lo largo de la historia en la literatura, y de cómo influyeron obras de Mark Twain o William Shakespeare.Cerramos el programa con un nuevo viaje cultural y esotérico en la sección Triangular de Carlos G. Fernández, que nos lleva hasta una tienda de discos en Esauira, en Marruecos. Una tienda que, en realidad, es una librería.Escuchar audio

Los misteriosos mundos subterráneos Cuevas y ciudades subterráneas en China, Turquía y Estados Unidos podrían confirmar leyendas sobre reinos ocultos y seres extraterrestres. ¿Qué secretos hay bajo tierra?

Bryan Johnson was diagnosed with autoimmune gastritis in 2026, and within a day the internet had already decided it was his vegan diet — I don't think it's that simple. In this episode I break down what autoimmune gastritis actually is, why Bryan's own data (crashed ferritin, failed iron absorption, a second autoimmune condition since he was 21) points to something deeper than food alone, and why both sides of this argument — "it's the diet" and "diet has nothing to do with it" — are missing the real pattern. I walk through the genetics-plus-environment framework behind autoimmune disease, compare Bryan's lifestyle against how humans have lived for most of our history — sun exposure, food sourcing, community, caloric rhythm — and lay out the specific changes I'd make instead, most of which don't cost you anything. If you've ever wondered whether optimizing your health can go too far, this one's for you. Thank you to this episode's sponsor, Peluva! Peluva makes minimalist shoes to support optimal foot, back and joint health. I started wearing Peluvas several months ago, and I haven't worn regular shoes since. I encourage you to consider trading your sneakers or training shoes for a pair of Peluvas, and then watch the health of your feet and lower back improve while reducing your risk of injury.  To learn more about why I love Peluva barefoot shoes, check out my in-depth review: https://michaelkummer.com/health/peluva-review/  And use code MICHAEL to get 10% off your first pair: https://michaelkummer.com/go/peluva  Learn More: 2: 8 Key Primal Shifts for Ancestral Living: https://www.primalshiftpodcast.com/8-key-primal-shifts-for-ancestral-living/  59: Paleo, Keto, Carnivore [Navigating Dietary Changes as a Family]: https://www.primalshiftpodcast.com/59-paleo-keto-carnivore-navigating-dietary-changes-as-a-family/  In this episode: 00:00 Intro 02:37 Health optimization gone too far 03:02 Diagnosis facts and markers 06:08 Genes, diet, and autoimmunity 08:32 What we know and don't 10:28 Against nature comparison 13:45 Risk factors with data 15:34 Ferritin red flags 17:47 A better primal blueprint 19:33 Final thoughts Find me on social media for more health and wellness content: Website: https://michaelkummer.com/ YouTube: https://www.youtube.com/@MichaelKummer Instagram: https://www.instagram.com/primalshiftpodcast/ Pinterest: https://www.pinterest.com/michaelkummer/ Twitter/X: https://twitter.com/mkummer82 Facebook: https://www.facebook.com/realmichaelkummer/ [Medical Disclaimer] The information shared on this video is for educational purposes only, is not a substitute for the advice of medical doctors or registered dietitians (which I am not) and should not be used to prevent, diagnose, or treat any condition. Consult with a physician before starting a fitness regimen, adding supplements to your diet, or making other changes that may affect your medications, treatment plan, or overall health. [Affiliate Disclaimer] I earn affiliate commissions from some of the brands and products I review on this channel. While that doesn't change my editorial integrity, it helps make this channel happen. If you'd like to support me, please use my affiliate links or discount code.

Crece la presión sobre el centro de detención Delaney Hall después de que se conformara la muerte de una tercera persona detenida. Como parte de un programa de vigilancia electrónica ICE monitora actualmente a casi 54 mil inmigrantes mediante grilletes electrónicos. El proyecto del lujoso salón de baile de Donald Trump en la Casa Blanca sufre un nuevo revés. Su construcción fue detenida por un fallo de una corte de apelaciones.

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! Acceso anticipado para Fans - ** VIDEO EN NUESTRO CANAL DE YOUTUBE **** https://youtube.com/live/KY_GvKH53Z0 +++++ Hazte con nuestras camisetas en https://www.bhmshop.app +++++ En este episodio especial de Bellumartis desvelamos, con rigor histórico y sin sensacionalismos, una de las organizaciones más influyentes y debatidas de la Edad Moderna. Conversamos con Fernando José Vaquero Oroquieta, autor de "La constelación masónica" ** https://amzn.to/4uolXtT **, para hacer un recorrido completo por la historia de la Masonería: Sus raíces operativas en los gremios de albañiles medievales La transformación en Masonería especulativa en los siglos XVII-XVIII Sus fuentes doctrinales: templarismo, rosacrucismo, hermetismo, kábala y racionalismo ilustrado Su papel como red intelectual y “intelectual orgánico” de la Modernidad Su relación (y enfrentamiento) con la tradición católica y las monarquías Cómo sus ideas y estructuras siguen proyectándose en las élites y dinámicas geopolíticas actuales Un análisis objetivo, documentado y profundo que ayuda a entender mejor el mundo contemporáneo, lejos de conspiraciones fáciles y también lejos de la ingenuidad oficial. Fernando Vaquero nos aporta datos sólidos y contexto histórico de primer nivel. Como siempre en Bellumartis: rigor, honestidad, enfoque histórico y perspectiva occidental. ¿Es la Masonería una simple sociedad filantrópica? ¿Una red de poder? ¿Un vehículo de ideas modernas? Te invitamos a descubrirlo con evidencia histórica. ¿Qué opinas tú? ¿Crees que la Masonería sigue teniendo influencia real hoy? Déjanos tu comentario, leemos todos. "Un Mundo Convulso. Claves geopolíticas" https://amzn.to/4dSKnqp SUSCRÍBETE a @BELLUMARTISACTUALIDADMILITAR y @BELLUMARTISHISTORIAMILITAR para no perderte ningún programa y únete a nuestra comunidad de apasionados por la historia militar, la geopolítica y los conflictos del mundo. Apóyanos para seguir creando contenido riguroso e independiente: Patreon: / bellumartis PayPal: https://www.paypal.me/bellumartis Bizum: 656 778 825 Síguenos también en redes: Instagram: / bellumartis_historia_militar Twitter / X: / bellumartis Bellumartis Historia Militar — Porque entender el pasado es prepararse para el futuro. #Masoneria #HistoriaModerna #Historia #FernandoVaquero #Bellumartis ️Escucha este episodio completo y accede a todo el contenido exclusivo de BELLUMARTIS PODCAST. Descubre antes que nadie los nuevos episodios, y participa en la comunidad exclusiva de oyentes en https://go.ivoox.com/sq/618669

The show-ending “Smoking Gun” segment on the Wednesday Bob Rose 8-5-26

In this inspiring episode, Jed welcomes two wonderful guests whose work helps kids feel seen, valued, and excited about reading. First, Jed talks with Melissa White Boyer, author of I Am Rare: Discovering What Makes Us Shine. Inspired by her son's diagnosis with the rare genetic disorder Weidman-Steiner syndrome, Melissa shares the long, emotional journey to finally getting a diagnosis and the shock of realizing there was no roadmap for what came next. She explains how that experience led her and her husband to found the Rare Genes Movement nonprofit, and how her picture book helps all children—whether they have a diagnosis or not—understand that their genes make them unique and that, like stars in the sky, they are meant to be admired, not changed. Melissa also reflects on finding purpose in difficulty, building inclusive school communities, and the joy of watching her son read to his younger sister. Then, Jed is joined by returning favorite Lydia Lukidis, author of the graphic novel Groucho the Grouchy Groundhog: The Terrifying Turnip Takeover. Lydia talks about her lifelong love of comics, the quirky origins of Groucho, and what it's like to write a graphic novel when you're not the illustrator. She and Jed dive into how graphic novels can be a powerful bridge for reluctant readers, why making kids laugh is a worthy goal all by itself, and how letting kids choose the "right" book for them can ignite a lasting love of reading. Together, these conversations celebrate difference, inclusion, and the joy of sharing stories as a family.

A groundbreaking study reveals that men with certain genetic variants face dramatically higher fertility risks when exposed to electronic radiation—especially as they age. In this episode, I break down new research from West Bengal that examined over seven hundred azoospermic men and found a troubling gene-environment interaction. Specific variants in three key meiotic regulator genes—combined with electronic radiation exposure—significantly increase the risk of complete sperm absence, particularly in men over thirty. This isn't about everyone being equally vulnerable. It's about understanding your personal risk factors. In This Episode How genetic variants in SPO11, RNF212, and SYCP3 genes affect male fertility Why electronic radiation exposure may exacerbate meiotic errors in genetically predisposed men What this means for fertility screening and assisted reproductive technology Practical steps to reduce exposure if you're planning to start a family Featured Study Read the full study: Men with genetic predisposition face greater fertility challenges when exposed to electromagnetic radiation See all studies at shieldyourbody.com/research

Anika and Liz beam over to a long-abandoned and extremely haunted space ship. And instead of talking about what we experienced over there in the shadows, we're going to discuss episode 2 of Star Trek: Strange New Worlds' fourth season, "The Griffin Institute".  This episode is a huge step up from the premiere! And also still super-duper into the eugenics of it all! The away team's biggest fear is … their genes! This whole subplot with La'an is really leaning into racist stereotypes about Chinese women "I am continuously horrified by how this series portrays Spock's internal conflicts."  The episode wants us to think that Carol Marcus is the bad guy in the relationship, not James T "actually I'm gonna go to this conference instead of seeing my infant son" Kirk We are obsessed with the conference. What could possibly be relevant to Spock, La'an and Jim? Was there only one bed?  We are a Pro T'Pring Podcast Does SNW actually want us to be engaged with Spock/La'an?  Liz has a pitch for a Division 12 comic (spoilers: it involves Lorca)

See all our training options at https://dyscalculiatraining.orgContact Dr Schreuder for your teacher professional training options drschreuder@dyscalculiaservices.com

- Por favor, inicia sesión en iVoox antes de escuchar o hacer comentarios. Los comentarios anónimos no son publicados. En esta entrega de Universo de Misterios, profundizamos en el proceso de formación estelar, analizando cómo las nubes de gas y polvo colapsan para dar origen a las estrellas. Exploramos las teorías actuales, desde el modelo estándar hasta la acreción competitiva y la turbulencia, y cómo las estrellas masivas desafían nuestra comprensión. Un recorrido por la astrofísica moderna y los mecanismos que permiten la creación de los elementos que nos constituyen. Aunque a algunas personas, a veces, puede proporcionar una falsa sensación de alivio, la ignorancia nunca es deseable. Pero eso, tú ya lo sabes... Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Jesús tomó en su frente una corona como cuando un buey va a trabajar y derribó la fortaleza sobre la cual se sentaba el enemigo para manipular a través de las imágenes en la mente del hombre, venció al enemigo y ahora espera que nosotros lo imitemos, tomemos nuestra cruz cada día y le sigamos al calvario para morir a nuestros deseos y renunciar a cualquier imagen altiva que nos lleve al pecar.

The Horror Miser Monty G joins us to kick off "Bad Genes" month. This one is a doozy from 2009 called "Splice" Starring Adrien Brody. We discuss the messy script, the "shock" moments, and if the special effects hold up. Tune in. Horror Miser Monty G's : https://www.youtube.com/@TheHorrorMiserMontyGVote in our "Party Like It's 1999" pollhttps://www.specialmarkproductions.com/partylikeits1999.html

El Festival de Poesía Red Dirt se lleva a cabo entre el 20 y el 23 de agosto en Alice Springs y celebra la poesía y la palabra hablada. Dentro del programa se fusionará el flamenco con algunos bailes tradicionales de las Primeras Naciones.Escucha SBS Spanish / Australia en español:Por radio o Internet 7 días a la semana de 1:00 a 2:pm (AEST)Escucha también por Apple Podcasts, Spotify y YouTubeExplora nuestra extensa colección de podcasts haciendo clic aquíEn redes: síguenos en Facebook e Instagram.

Las aguas profundas e inexploradas de nuestro planeta han sido siempre fuente de admiración y especulación sobre lo que se oculta en ellas. Las ruinas sumergidas de Dwarka, la estructura submarina en Yonaguni, Japón, o la extraña «ruta» descubierta cerca del Triángulo de las Bermudas, estas y otras estructuras subacuáticas antiguas son un indicio de la existencia de civilizaciones perdidas. Leyendas de ciudades acuáticas gobernadas por dioses, criaturas como el monstruo del Lago Ness o el Kraken, o los frecuentes avistamientos de ovnis… ¿estamos ante indicios que señalan una presencia sobrenatural que acecha en las profundidades submarinas?

Te mostramos en imágenes la crisis migratoria que atraviesa Ceuta. Miles de personas han llegado al enclave español en los últimos días, mientras las autoridades refuerzan los controles fronterizos.

Send us Fan MailDr. Michel Koren and Dr. Mitchell Rothstein host a presentation in front of a live audience to discuss the current state of gene editing. The doctoral duo discuss developments including new-to-market medical therapies, clinical trials, and the legal issues surrounding gene therapy patents. They also explain the difference between gene silencing techniques, which temporarily stop genes from creating proteins, and gene editing techniques which permanently alter the genome. They also touch on controversies, risks, and the comprehensive considerations that take place before a participant can partake in a gene editing clinical trial.Be a part of advancing science by participating in clinical research.Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.comListen on SpotifyListen on Apple PodcastsWatch on YouTubeShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramX (Formerly Twitter)LinkedInWant to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.comMusic: Storyblocks - Corporate InspiredThank you for listening!

Two years after researchers identified ReNU syndrome, where are we now?   In 2024, two independent research teams identified the genetic cause of ReNU syndrome, a rare neurodevelopmental condition affecting thousands of people worldwide. The discovery marked the beginning of a new chapter for families searching for answers and opened up exciting new avenues for research.  In this episode, host Sharon Jones revisits the story to explore what has happened since that breakthrough. She is joined by: Professor Nicky Whiffin, Associate Professor and Wellcome Career Development Fellow at Big Data Institute and Centre for Human Genetics, University of Oxford Christina Cox, Co-founder of ReNU Syndrome UK and parent of a child with ReNU syndrome Dr Ana Lisa Tavares, Clinical Lead for Rare Disease at Genomics England Together, they discuss how researchers around the world have built on the original discovery to deepen our understanding of ReNU syndrome, why studying the non-coding regions of our DNA is revealing previously unknown rare conditions, and how collaboration between researchers, clinicians and families is accelerating progress. They also explore how the growing ReNU community is supporting newly diagnosed families and what the future could hold for new treatments.  Links:  Previous episode detailing the discovery of ReNU Syndrome  ReNU Syndrome UK's website  Original research paper from Nicky's team in Oxford  Original research paper from the team based in New York   “It's been only two years since our paper came out about this, and in that time, there are now patient family groups that have been set up all around the world. There is the one in the UK led by Christina and the others. There's the one in the US that's led by a group of four women, and there are ones in France, Spain, like, literally all around the world. And all of these groups are also somewhat coordinated. The leads of these groups meet with each other. They've organised meetups. I've been to ones in the US, the UK, and in France. So the fact that they can mobilise all of that and create such a community so quickly is absolutely incredible.”  You can download the transcript, or read it below. [00:00:00] Sharon: In 2024, two independent research teams identified a genetic cause of a rare neurodevelopmental condition affecting thousands of people around the world. Since then, that initial groundbreaking discovery has grown into something much bigger, bringing together families, researchers, and clinicians, and building a clearer picture of what we now know as ReNU syndrome.  [00:00:26] Sharon: Welcome to Behind the Genes, the podcast that covers everything from cutting-edge research to real-life stories in genomic healthcare. I'm Sharon Jones, and in today's episode, we're looking at what's happened since that discovery, what researchers are continuing to learn, and what the future could hold for people living with  ReNU Syndrome and their families.  [00:00:46] Sharon: To help us understand more, I'm joined by Professor Nicky Whiffin, Christina Cox, and Dr. Ana Lisa Tavares. So, two papers were published around the same time for this condition. To start us off, Nicky, you worked on one of these papers. Could you explain how this journey first began?   [00:01:05] Nicky: Yeah, so this was two years ago now, back in early 2024, where two research teams, so us based in Oxford and a, a group based in New York, were both looking at the data within the National Genomics Research Library, and we both kind of somewhat simultaneously found that there was variance in this very, very small gene, it's called RNU4-2, were found in individuals with previously undiagnosed neurodevelopmental disorders.  [00:01:39] Nicky: And this was very, very striking because we initially actually identified the same single DNA change or mutation in 40 or so different individuals within the National Genomics Research Library, and we normally expect to see a whole host of different variants. We don't expect to see the same one.  [00:01:59] Nicky: So this was a really, really surprising finding. And it was through a collaboration, large scale collaboration across the world where we started contacting our other collaborators who have similar collections of patients who have been genome sequenced to ask if they had any individuals with DNA changes in this gene.  [00:02:17] Nicky: And we found some in the US, some in, in Australia, some in France and Germany. So very, very quickly built up this, this complete picture of variants in this gene, causing this rare neurodevelopmental disorder   [00:02:35] Sharon: of people finding it at the same time, what, what did that feel like?  [00:02:39] Sharon: Like, give us a ense of, like, that compelling, "We think we found something." What was that like?   [00:02:46] Nicky: I didn't believe it initially. You're always told when you're a scientist that if it looks too good to be true, it's, it's not true, and this basically lit up like a beacon. There's this particularly one DNA change that we found in, um, I think it was about 40 different individuals, and we don't really expect that to be the case.  [00:03:04] Nicky: We normally expect these genetic variants to be somewhat randomly distributed across the genome. So to find 40 individuals with exactly the same DNA change was very, very surprising. So initially, I didn't believe it. The whole team, including folks at Genomics England, spent a lot of time trying to check that these variants were real and tried to disprove the result, tried to find any other way in which any other reason why we would be seeing this.  [00:03:31] Nicky: And after a little while, we had to concede that we couldn't disprove it, so it must be true, and that, that was a very exciting moment.   [00:03:38] Sharon Jones: Was it the case that over in the States, the exact same thing was happening?   [00:03:42] Nicky: I think we found out when we were both speaking at the same conference, actually. So we didn't actually know that we, that we'd both come across the same result.  [00:03:49] Sharon: If you want to check out our previous episode on this initial discovery, you'll find a link to it in the episode description.  [00:04:00] Sharon: So Christina, tell us a bit about your situation, your family situation, and for our listeners, what ReNU is.   [00:04:05] Christina: So ReNU is, to us, is a family. We got a family when we got diagnosed with  ReNU. Beau - Arabella - already had other diagnosises, but people had always said to us, "Oh, there's something else. There's something else.  [00:04:20] Christina: We're not sure what it is, but there will be something." And then when we got  ReNU, it was like, "Oh, okay, amazing. What do we do? What is it?" Because there was only four lines on Wikipedia when we first got told about it, and there wasn't anything that, ourselves could find. So we kind of went onto Facebook and looked for groups and different people, and there wasn't really anything except for Jess in America.  [00:04:46] Christina: And then it grew, and then it kind of, we ended up finding more people in the UK and, like, all over. But for us, it didn't really change how we perceived Beau. It just made life easier. Like, knowing there was other families out there that we could find advice from and support from, and that we kind of knew what we had and going forward then, like, finding researchers and connecting with everybody.  [00:05:15] Sharon: Yeah. And for those who don't know, can you talk about what  ReNU is? Like, how does it affect Beau?   [00:05:20] Christina: So with Beau and  ReNU , it affects her with developmental delay. She's non-verbal. She's incontinent. She suffers for walking, so she can do a little bit of walking, but she needs a wheelchair It affects her mood swings.  [00:05:38] Christina: It just affects everything. Although she has it, she's still a happy, outgoing, very stubborn, just kind of "keep-going" child. But it affects her in everything, like eating, sleeping.   [00:05:51] Sharon: It sounds like life is, you know, very challenging on a day-to-day basis, lots of considerations. How did you feel when you finally got this diagnosis after years of wondering and waiting, not knowing?  [00:06:02] Christina: Finding out was, like, really emotional because it was like, "Oh, wow, so we have this diagnosis. Now what? What are we looking for? What's going to happen?" And then we were kind of like, "Oh, but there's not many people that had it." Because we found out in the August, so then it was trying to find people. But it has been life-changing to know that we're not on our own and that there is other people around.  [00:06:28] Sharon: Yeah, tell us a bit more about that. How did it feel to get that diagnosis?   [00:06:32] Christina: It was quite strange because our pediatrician rang us and said, "Oh, we've got a diagnosis. She's got RNU4-2." And we were like, "Okay, so what's that?" And she's like, "I don't really know. There's four lines on Wikipedia at the moment."  [00:06:46] Christina: She goes, "I don't like Wikipedia," but we still kind of... That was it. So then we went on a mission to find and look for where we could find support and find other families.   [00:06:58] Christina: At that point, I didn't know of anybody in the UK, and my husband found Jessica in America. What then, kind of, we had somebody to talk to, and then families in the UK kind of started appearing.  [00:07:09] Christina: So we ended up getting a whole network of people to bounce ideas off and talk about how it affects their children and what's for the future and things like that. It was really nice.   [00:07:22] Sharon: Yeah, yeah, I can imagine. So Ana Lisa, how do these findings contribute to a growing understanding of the condition?  [00:07:29] Ana Lisa: So this was an amazing discovery. Although we're finding new rare conditions quite often, not on this sort of scale. It was also an amazing finding because a lot of the genes that we know are associated with rare conditions are genes that encode proteins, and in the 100,000 Genomes Project, we were doing whole genome sequencing, and Nicky and her team were looking in the parts of the genome that don't encode for proteins.  [00:08:03] Ana Lisa: And so this was, uh, exciting from that point of view as well. So the vast majority of our genome, more than 98%, does not encode for proteins, but it's relatively unexplored. And if we think about our genome and the letter code that makes it up, which is the manual for how our bodies are built, and grow and function day-to-day.  [00:08:30] Ana Lisa: Those 3 billion letters, if you, if you printed them out in a 12 font regular print, it would stretch so far you could fly, I think, from London to Paris several times, maybe three times or something. And so, this actual gene is a very, very small gene, less than 150 of those letters. So again, it was incredible to find that by comparing across many, many different genomes in the National Genomic Research Library.  [00:09:00] Ana Lisa: Going back to your question about a growing understanding of a condition, it was a completely new condition, but it also opened up looking at other related genes and actually now more disorders that are being found, like RNU2-2 by colleagues in the US, and that might be one of the most common recessive genetic neurodevelopmental disorders.  [00:09:27] Ana Lisa: So it's really, really opened up this understanding about these types of disorders and also those non-coding parts of our genome and the power of collaboration and being able to look across many different whole genomes at the same time.   [00:09:44] Sharon: Yeah. And Nicky, you've been involved in much of this research journey.  [00:09:50] Sharon: What have been some of the biggest advances or learnings for you so far?   [00:09:55] Nicky: I think the biggest one is just how common, or how frequent, these disorders are. So what we discovered recently in terms of new genetic disorders were rarer and rarer conditions, and that's why we hadn't seen them before. But from going from looking at the protein coding genes to looking at these non-coding genes, we found something that was as frequent as disorders that were found in the early 2010s when we first had large-scale sequencing projects that looked at the protein coding genes.  [00:10:26] Nicky: So that was really, really surprising. And we now know there's this whole class of disorders. So RN4-2, this gene encodes this -- Well, it produces this small RNA that works in this huge molecular machine that is called the Splicer Zone, that mediates the processing of most of the other genes across the genome.  [00:10:50] Nicky: And there are lots of these little RNAs that work in this molecular machine that are called the small nuclear RNAs or the snRNAs And we now know that there are a whole multitude of different disorders associated with different ones of these spliceosomal small nuclear RNAs, and that's really incredible.  [00:11:09] Nicky: And for RNU4-2 itself, we also now know that there are, there's not just RENE syndrome, uh, which is a dominant disorder caused by chance de novo variants that are newly arisen in a child, but also a recessive disorder where a child inherits one, uh, gene mutation from each parent. And also another finding that there is a region of the gene where we find DNA changes that cause retinitis pigmentosa, so a retinal phenotype. So we now know a huge amount more about this single gene, but also all of this different class of genes or RNAs that work in the same molecular machine, uh, which is, is really fascinating biologically   [00:11:52] Ana Lisa: Vicky, while you were talking, I was thinking about the splicing and how a bit like this podcast recording, you're going to splice out the kind of extreme, the noise that wasn't supposed to be there.  [00:12:03] Ana Lisa: And actually, you could make slightly different versions of this podcast, couldn't you? And that's, that's what, what's happening in our bodies for a lot of our genes that, that the kind of output can be varied slightly.   [00:12:15] Sharon: So Christina, how has collaboration been involved across the community and with researchers?  [00:12:21] Sharon: You know, what sort of things have you been doing?   [00:12:23] Christina Cox: So it's amazing to have researchers that are so open and amazing to work with the families. So at the moment, we are just putting together like a panel to discuss questions from families, to then be able to answer families, to work very closely with the researchers for what things are happening and the progress within.  [00:12:47] Christina: It's just amazing to be able to work with researchers. They're just fantastic.   [00:12:52] Sharon: And from what I understand, like, you, you have a charity, don't you? Can you tell us a bit more about that and how that came about?   [00:12:58] Christina: So we have ReNU Syndrome UK, and it came about as there was a group of us parents that were like, we wanted to be able to support other families, knowing what it was like for us when we first started.  [00:13:12] Christina: It was very difficult. So we wanted to start a charity that can support families and signpost them, give them the opportunity to have family meetups once or twice a year, so we can work with scientists and specialists to keep everybody in the community, like the ReNU family, up to date. But being able to connect with so many families, because a lot of the doctors don't really know of ReNU Syndrome yet.  [00:13:46] Christina: So if we have a problem or a question, we put it in the WhatsApp group, and then somebody can answer it because they've been through it, or they, they've just asked the question. So it's just an amazing resource for everybody   [00:14:02] Sharon Jones: That sounds amazing, and it sounds like you've all obviously become experts by experience.  [00:14:04] Sharon: So, like you say, you kind of know more, you know, as the science develops, but you're living it every single day   [00:14:10] Christina: It's kind of, you go into the hospital and they're like, "Oh, what's ReNU Syndrome?" And then you're like, "Ugh." So, then you just have to say it all. But, and then it's kind of them bringing, teaching new people who don't know about it in the medical professional.  [00:14:26] Christina: We always give them the website so that they can go and then find, but being able to put more medical stuff on the website, it just helps everybody, and it's just broadening it out to as many people as possible. Because there's still a lot of people undiagnosed with RNU syndrome. It's, now it's easier to be signposted, but it's just keeping that connection.  [00:14:49] Sharon: Yeah. And, and from what I understand, it's got quite an interesting sort of origin of a name, RNU. Where did that... Do you know much more about where that came from?   [00:14:57] Christina: So, Nicky is the amazing person who, um, sorted the name and um, the origin. So, I'll pass that over to Nicky to answer that question because she's just amazing   [00:15:11] Nicky: Uh, so the name ReNU syndrome is an interesting story.  [00:15:13] Nicky: So, a lot of disorders or diseases are named after people. So, we all know Alzheimer's, Parkinson's, etc. And they're often scientists or clinicians that have spent a lot of time working on them. I think that's a little bit odd. I don't think it's the first thing that somebody should know about a disorder, is the name of somebody who's, who's worked on it or studied it.  [00:15:36] Nicky: But they're a very, it's very hard to find an alternative. When we were initially doing the press release around our paper, we had a quote from one of the mothers, Nicole Cedar, who has a, a wonderful daughter called Mia Joy, and she said that within their family, they like to refer to RNU, to RNU4-2 as ReNU, which is a really nice play on the RNU in the gene name.  [00:16:00] Nicky: So then I had an idea, okay, let's just change the spelling to make the, the kind of big R, little E, large N-U, then it would link to the gene name, but also would be a name that speaks to hope and the renewed hope of being given a diagnosis.   [00:16:13] Sharon: Yeah, absolutely, and that's a great, a great story and a great way of kind of making it feel like there is, there is always hope.  [00:16:20] Sharon: So, you know, Nicky, you're now part of the patient community. In a way. You know, so how does it feel to be on that other side of it from that sort of research perspective and now kind of, you know, in that, in that community?   [00:16:34] Nicky: It's amazing. I've got a new family as well. It's not, not just Christina and everybody.  [00:16:39] Nicky: I kind of, I'm a, a basic scientist. I'm not a clinician. Up until this point, we've always been one or two steps removed from actually interacting with the families themselves. Um, so my life has changed an awful lot over the last couple of years, uh, where now, um, I kind of talk to Christina or the folks in the US, really regularly, kind of on a weekly basis.  [00:17:02] Nicky: Um, so that's really different. And I just kind of want to highlight just what these families have achieved. So it's been only two years since our paper came out about this, and in that time, there are now patient family groups that have been set up all around the world. There is the one in the UK led by Christina and and the others.  [00:17:26] Nicky: Um, there's the one in the US that's led by a group of four women, and there are ones in France, Spain, like, literally all around the world. And all of these groups are also somewhat coordinated. The leads of these groups meet with each other. They've organised meetups. I've been to ones in the US, the UK, and in France.  [00:17:46] Nicky: So the fact that they can mobilise all of that and create such a community so quickly is absolutely incredible. And they've got families, they've got so many researchers that are interested in the cause. They're interacting with the pharma companies. They've upskilled themselves to learn so much about genetics.  [00:18:04] Nicky: And it's just an absolutely incredible thing to watch. They're so, so inspiring.   [00:18:09] Sharon: And from what I understand, Christina, you feel, you know, very passionate about Nicky in the same way, about your paths crossing in this way.   [00:18:16] Christina: Oh, my, yes. Every time I see Nicky, I've met her a couple of times, like, in person now, I just cry.  [00:18:22] Christina: I literally, we saw her at the UK meetup, and she walked in the door, and that was it. I was done. I was like, it's just meeting somebody who has changed so many lives and brought a community to other families. It's just amazing. And the support that Nicky's giving us weekly, daily, is just amazing. It is just life-changing for all of us.  [00:18:49] Sharon Jones: It's such a powerful connection. So Ana Lisa, why is collaboration between researchers, clinicians, and families so valuable in the rare disease research space? You know, and what role do large scale research projects and data sharing play in discoveries like this?   [00:19:06] Ana Lisa: Collaboration is completely incredibly valuable and for progress in the rare disease space where there's just so much still to learn.  [00:19:16] Ana Lisa: So more than half of patients and families where, uh, they're seeking a potential diagnosis, we're not yet able to, to find one, and there's so much yet that we still need to learn, and collaboration in so many different spaces and directions and across different spheres enables this progress. So for example, the fact that we have a really connected, uh, National Health Service and really close working between the NHS and Genomics England so that we can, for those patients and families that, that consent to their de-identified data being shared in the National Genomic Research Library, be able to work with many, many different researchers, uh, whether they're academic, institutions, industry, and try and find all the patients that could benefit from a new diagnosis and, uh, potentially new therapies in future clinical trials.  [00:20:21] Ana Lisa: And without that collaboration, it would be really, really hard to find all those people So because we sort of have a clinical research interface where we can go back to clinical teams and therefore to patients and families, even if there's a really, really ultra-rare condition with very few people known to have it that could be under different specialties in different regions, we would be able to contact their clinical team.  [00:20:51] Ana Lisa: So I think that, that collaborative working with the NHS is really powerful across researchers worldwide. Like in this example where a group in Oxford and a group in US were able to make this finding and then all the other findings that are coming from it. And really, without being able to compare across thousands of genomes, one wouldn't have been able to see this, this particular signal and see that there were more than 100 patients, and that was really powerful.  [00:21:20] Ana Lisa: If you just had one genome, you could never have made this novel discovery. I think the other thing is that, and Nicky will say that, you know, she, she then contacted her collaborators who also had access to, to, to data that had been shared by other families and could compare. And again, it's a whole sort of network across the globe.  [00:21:41] Ana Lisa: And we know that there are going to be many more diagnoses to be found. But also, um, I think collaboration will allow us to find new, new treatments. So if we can start to design treatments that target the DNA and RNA at, at source, then actually you could collaborate and say, "Well, this type of genetic mechanism could be targeted in the same way, potentially across even more than one rare condition and reach even more patients."  [00:22:13] Ana Lisa: And actually the power of collaboration across the ecosystem is that hopefully we'll end up with a pathway that can actually go from finding a new genetic finding, like Nicky and her team made, to helping all the people who could benefit from a diagnosis, having one, and then can one develop a treatment and get it to as many patients?  [00:22:42] Ana Lisa: And, and I think that will really demonstrate the power of collaboration.   [00:22:47] Sharon: Yeah. Absolutely, and it can only, you know, benefit those families who have to wait such a incredible amount of time.   [00:22:55] Ana Lisa: There's been such a diagnostic odyssey, and as more diagnoses are made, it becomes obvious that there's, uh...  [00:23:03] Ana Lisa: and it was, it's already well-described, the therapeutic odyssey. Um, but hopefully these sort of novel understanding of our genome and opening up new biological avenues to treat, um, hopefully will also enable many more new treatments to be developed.   [00:23:21] Sharon: Absolutely, and that is the key word there is, is that hope.  [00:23:24] Sharon: So, so looking ahead, Nicky, what developments are you most hopeful about over the next few years?   [00:23:31] Nicky: That's a difficult question. There's so much, so much happening. One thing is that we are gearing up to do large scale studies across the world to understand more about the progression of ReNU. So you might call them large scale natural history studies or just large scale profiling studies where we can do a range of different tests on ReNU patients and, and monitor them over time.  [00:24:02] Nicky: So do those at regular, regular intervals over time so we can see what the progression looks like. And that's really important for trying to think about whether we can treat RNeU syndrome. And on that note, I'm very also excited about the potential for therapeutics. There's lots of people all around the world, both, uh, in academic settings, but also in pharma companies trying to work out whether this is something that we can treat.  [00:24:30] Nicky: There's some very promising early data to show that we can selectively remove the RNA containing the mutation from cells, uh, leaving the copy of the RNA that doesn't contain the mutation intact so that can do the correct function. And biologically, we think this should be an effective treatment.  [00:24:54] Nicky: Um, so we can do that in cells in a dish. We don't yet know whether we can do that in a patient with ReNU. Uh, but that's really, really promising early data. Um, so I'm very hopeful about where that, those studies might lead.   [00:25:08] Sharon: And Ana Lisa, what role will genomics continue to play in improving understanding and care for rare conditions like this?  [00:25:15] Ana Lisa: So following on from what Nicky said, I think the really big hope is that we will be able to develop many, many new treatments collaboratively across the world. And whether these are individualised treatments made for one patient but then shared because we can find perhaps other patients who could benefit from the same treatment, whether we understand the genetics better so that we can design treatments from the start that will work for a lot of patients.  [00:25:46] Ana Lisa: So I think there will be sort of fancier and fancier ways of targeting rare conditions. And right now we're in a phase where the ecosystem is trying to work out how could we make an end-to-end pathway with initiatives like the Rare Therapies Launchpad in the UK, and that's going to require truly collaborative working.  [00:26:08] Ana Lisa: No single organisation can do that. And I think having these incredible use cases will be really powerful for turbocharging the development of these pathways. And the hope is that once you've worked out how to do this across a range of different rare conditions, that one might reach a stage where one could do that a lot faster for many other rare conditions.  [00:26:35] Ana Lisa: Because at the moment they're so underserved in terms of treatments available and there's a huge gap between being able to make a genetic diagnosis and then having treatments. The big hope is that understanding the genetics better will help to open up new pathways to treatment. I do hope that we'll also understand other aspects.  [00:27:02] Ana Lisa: So for example, it might be that understanding the genetics better also helps us to understand different ways a condition might manifest in somebody, why it may be different from one person to another, why somebody might be more mildly affected and somebody perhaps more severely. And that might, may also help us to understand ways to treat a condition by getting, gaining these insights which are, are useful in and of themselves and may also lead to new therapeutic, uh, possibilities.  [00:27:36] Ana Lisa: I think that would be one of my hopes that a lot of these areas overlap and lead to real benefit for patients and families, that we can translate that hope into concrete improvements in treatment for rare conditions.  [00:27:57] Sharon: Do you have a sense of time, how long you think this could all take, that amount of collaboration?  [00:28:06] Ana Lisa: Yeah, and I think this is actually another reason why sometimes it's quite tricky to make progress in this area because being able to predict those timelines is notoriously difficult when you look back historically. I'd like to hope that we're on the cusp of having an explosion of novel treatments that can target DNA and RNA, for example, or treatments that target something in the underlying biology that we now understand that we didn't before.  [00:28:34] Ana Lisa: And I do think that there is going to be a big shift. But I think that the sort of confidence intervals around how big that range of time might be is very hard to predict. And that's why I think Christina and Nicky being able to share these stories and about their collaborative working really shines a spotlight on, on what could be done and how progress can happen.  [00:29:02] Ana Lisa: That's really exciting. The other day at a conference, someone from industry stood up and said, "Oh, actually, we set up a clinical trial in the UK because we knew there were patients who could benefit from our work in the National Genomic Research Library," and that was really exciting for us because that's what we want to do; move forwards the opportunities for treatment for patients.  [00:29:28] Sharon: And so finally, Christina, as a parent and member of this community, what are your hopes for the future, and what would you say to families who may still be searching for answers today?   [00:29:39] Christina: It is a long journey, but there is the support and the help out there. If you have any inclination that you think you might have ReNU, reach out to your paediatrician or your doctor to see if you can get your genetic testing done because it's fighting to get the test, to go to people and say, "I think this is what we may have. Can we look into getting it tested?" And reach out to other families and the website and things because it's all about community and supporting and helping people find that diagnosis.   [00:30:16] Sharon: Thank you, Christina, and we'll put the website in the episode description. A huge thank you to Professor Nicky Whiffin, Christina Cox, and Dr. Ana Lisa Tavares for joining me today and sharing their insights and experiences. To learn more about ReNU Syndrome, visit renusyndromeuk.org. If you'd like to hear more stories about the people, research, and discoveries helping to shape the future of healthcare, subscribe to Behind the Genes on your favourite podcast app.  [00:30:45] Sharon: Thank you for listening. I've been your host, Sharon Jones. Behind the Genes is produced by Deanna Barac, Florence Cornish, Sophie McLachlan, and Katie Revell at Bespoken Media. 

What if your brain is changing at the molecular level -- but you feel completely fine? A new study on five G exposure reveals something unsettling: biological effects that don't show up in behavior tests. I'm R Blank, and in this episode of the Healthier Tech Podcast, I break down recent research examining five G signals at three point five gigahertz. The findings challenge a common assumption in wireless safety standards -- that if behavior looks normal, everything must be fine. The reality is more complex. In This Episode What researchers found when they exposed mice to five G signals repeatedly Why normal behavior doesn't necessarily mean normal biology The gap between current safety standards and emerging science One practical step you can take today to reduce your exposure Featured Study Read the full study: Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice See all studies at shieldyourbody.com/research

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Por favor, inicia sesión en iVoox antes de escuchar o hacer comentarios. Los comentarios anónimos no son publicados. En esta entrega de Universo de Misterios, celebramos nuestro octavo aniversario con un episodio especial grabado durante una acampada. Entrevistamos a la Comandante Aida, quien nos relata su fascinante trayectoria vital: desde su juventud en Ciudad de México hasta su profunda experiencia misionera en la Sierra Tarahumara. Un recorrido personal donde descubrimos el origen de su apodo, su labor con los rarámuris y cómo el destino cruzó nuestros caminos en este proyecto radiofónico. Aunque a algunas personas, a veces, puede proporcionar una falsa sensación de alivio, la ignorancia nunca es deseable. Pero eso, tú ya lo sabes... Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Conocemos a Álvaro García Cuesta, cámara de la selección española, que ha grabado imágenes inéditas de cómo se ha vivido el Mundial 2026 por dentro

Mensajeros alienígenas A lo largo de la historia, figuras como profetas bíblicos, el Oráculo de Delfos, Juana de Arco, Washington, Einstein o Tesla han atribuido su sabiduría a fuentes sobrenaturales.

What if breast cancer risk is not determined only by your genes or family history? In this episode, Dr. Taz sits down with double board-certified breast cancer surgeon and lifestyle medicine physician Dr. Kristi Funk to discuss why breast cancer is becoming more common, especially among younger women, and what women can do to better understand and potentially reduce their risk.Dr. Funk explains why 95% of women diagnosed with breast cancer do not have a BRCA mutation and why 87% do not have a first-degree relative with the disease. Together, Dr. Taz and Dr. Funk explore how food, alcohol, exercise, body weight, stress, inflammation, environmental toxins, sleep, and hormone therapy may influence breast health.They also break down some of the most confusing questions surrounding breast cancer screening and treatment. Do mammograms cause cancer? Is ultrasound a good alternative? When should women begin breast exams? Are some cases of stage zero breast cancer being overtreated? And how much does menopause hormone therapy actually increase breast cancer risk?Breast cancer screening is important, but screening and prevention are not the same thing. Understanding your individual risk factors can help you have better conversations with your doctor and make more informed decisions about your health.If you are navigating cancer treatment or recovery, concerned about inflammation, or want personalized support for your hormones and nutrition, explore related Hol+ care options here:Cancer Support:https://holplus.co/services/cancer-support/Inflammation:https://holplus.co/conditions/inflammation/Hormone Balancing:https://holplus.co/services/hormone-balancing/About Dr. Kristi Funk:Dr. Kristi Funk is a double board-certified breast cancer surgeon, lifestyle medicine physician, bestselling author, and international speaker. She graduated from Stanford University and received her medical degree from UC Davis before completing her surgical residency and breast cancer fellowship.Dr. Funk previously served as Director of the Cedars-Sinai Breast Center and co-founded the Pink Lotus Breast Center in Los Angeles, where she continues to practice. She has helped thousands of women navigate breast health and breast cancer, including Angelina Jolie and Sheryl Crow. She is also the author of Breasts: The Owner's Manual and the founder of the Cancer-Kicking! Summit.Connect with Dr. Kristi Funk:https://www.instagram.com/drkristifunkhttps://pinklotus.com/About Dr. Taz:Dr. Tasneem Bhatia, also known as Dr. Taz, is a triple board-certified integrative medicine physician, bestselling author, and founder of hol+, a multi-location integrative medicine practice.Learn more: https://doctortaz.com/aboutStay Connected:Connect further to Hol+ at https://holplus.co/ - Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.Book a Hol+ Consultation: https://holplus.co/locations/virtual/Follow Dr. Taz on Instagram:https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Subscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsHost & Production TeamHost: Dr. Taz; Produced by ClipGrowth.com (Producer: Pat Gostek)Chapters0:00 Why breast cancer is rising6:20 Why most cases are not genetic14:53 The biggest breast cancer risk factors34:25 How stress and inflammation affect risk40:33 Breast exams, mammograms, and screening49:40 Are we overtreating stage zero breast cancer?57:20 Hormone therapy and breast cancer risk

Is extra virgin olive oil really as healthy as people claim? Or has it become another nutrition trend surrounded by conflicting opinions?In this solo episode of Everyday Epigenetics: Raw. Real. Relatable., Susan Robbins explores the science behind one of the most researched foods in the world: extra virgin olive oil (EVOO). Drawing from years of reviewing DNA reports, biomarkers, epigenetic testing, and current research, Susan explains why EVOO continues to stand out as one of the few foods she consistently recommends across a wide range of clients. She also breaks down common myths about dietary fat, cooking with olive oil, cholesterol, and why personalized nutrition will always matter more than following the latest diet trend.Whether you're trying to support heart health, reduce inflammation, improve insulin sensitivity, or simply make more informed food choices, this episode will help you understand why food is more than fuel, it's information that influences how your body functions every single day.In this episode:Why extra virgin olive oil continues to stand out across genetics, biomarkers, and nutrition researchThe connection between EVOO, inflammation, insulin sensitivity, cardiovascular health, and healthy agingWhy personalized nutrition is more effective than following one popular dietThe truth about cooking with extra virgin olive oil and whether it really is stable when heatedHow your genes influence the way your body responds to different dietary fatsPractical tips for choosing a high-quality extra virgin olive oil and incorporating it into your daily routineIf you've ever wondered whether olive oil deserves its reputation as one of the healthiest foods you can eat, this episode offers a practical, science-backed perspective that may change the way you think about one simple ingredient.RESOURCES:Find all of Susan's Resources and links in the show notes: Oxidative Stress Episode: https://healthyawakening.co/2025/12/19/episode102/Cholesterol Episode: https://healthyawakening.co/2026/03/16/episode115/https://healthyawakening.co/2026/07/20/episode133/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

We're exploring how your unique genetic blueprint can serve as a roadmap for optimizing health, longevity, and performance. Combining functional lab testing, genetic insights, and personalized nutrition creates a more holistic picture of your biology and health.   Key Takeaways To Tune In For: (00:00) - Genetics, Functional Testing, and Personalized Health (06:58) - Why Genetics Alone Is Not Enough (09:47) - Using Genetic Insights to Reduce Inflammation (18:11) - Bridging Genetics, Nutrition, and Supplement Needs (20:51) - The AMY1 Gene and Your Ideal Diet (31:37) - Genetic Food Sensitivities and Personalized Nutrition   Resources talked about in this episode: Websites: http://www.DrSamShay.com   Social media handles: http://youtube.com/@DrSamShay https://www.facebook.com/sam.shay.792/ https://www.instagram.com/drsamshay/ https://www.linkedin.com/in/dr-sam-shay-dc-ifmcp-922133128/

A Note from James:I've been obsessed with anti-aging and longevity science for a long time. I've had many longevity researchers on the podcast, but this episode feels different because something we've been discussing for years has now moved into human trials.David Sinclair first came on the show in 2019, when his book Lifespan was published. He's a professor of genetics at Harvard Medical School, and that first conversation changed how I lived. I started experimenting with intermittent fasting, paid much more attention to sleep, and began researching many of the supplements and lifestyle changes he discussed.But the most important idea David talked about wasn't a supplement. It was the possibility of reversing cellular age using Yamanaka factors—genes that can reset the instructions cells use to function. At the time, nobody knew whether this could be done safely without causing cancer or making cells lose their identities.Now, a therapy based on three of those factors has entered its first human clinical trial. The initial target is age-related damage to the optic nerve, including open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy. The trial is designed primarily to evaluate safety, but researchers will also measure visual function.David explains how this technology worked in mice and nonhuman primates, why the eye was chosen as the first organ, and how the same approach might eventually be applied to the liver, lungs, joints, skin, and brain.We also cover the practical questions people always ask him: NMN, NAD, metformin, berberine, testosterone, growth hormone, diet, fasting, sleep, exercise, and what David himself has started—or stopped—taking.This is still experimental science. Nobody yet knows whether the animal results will translate into meaningful benefits for humans. But for the first time, researchers are beginning to test that question directly.About Lifespan: Dr. David Sinclair founded Lifespan to deliver clear, science-backed health insights that help people live longer, more vibrant lives.He's now building the world's largest community dedicated to extending human longevity well beyond today's limits. Join early access at lifespan.com. New episodes of Lifespan with Dr. David Sinclair -- the #1 health and wellness podcast in its first season -- are now available on YouTube, Spotify, Apple Podcasts, and Lifespan.com.Episode Description:For years, longevity researchers have looked for ways to slow the biological processes associated with aging. Dr. David Sinclair and his collaborators are now testing a more ambitious possibility: whether damaged human cells can be restored to a younger, more functional state.The experimental therapy, ER-100, uses controlled expression of three transcription factors—OCT4, SOX2, and KLF4, collectively known as OSK. These are three of the four Yamanaka factors originally used to transform adult cells into pluripotent stem cells.Turning on all four factors can erase too much of a cell's identity and has produced tumors and fatal outcomes in animal experiments. Sinclair's team found that removing one factor, c-MYC, allowed cells to regain younger patterns of gene expression without completely returning to a stem-cell state.In preclinical studies, OSK restored youthful epigenetic patterns, promoted optic-nerve regeneration, and reversed vision loss in mouse models. Life Biosciences, a company Sinclair co-founded, has now moved the technology into a first-in-human Phase 1 trial involving people with open-angle glaucoma or non-arteritic anterior ischemic optic neuropathy.David explains how the therapy is delivered directly into the eye and activated using doxycycline, allowing clinicians to control when and for how long the genes are expressed. He also describes the development path that could follow if the treatment proves safe, including therapies targeting the liver and other organs, as well as future medicines that may reproduce similar effects without gene delivery.The conversation then turns to interventions available today. David distinguishes between promising research and claims that have moved ahead of the evidence, discussing NMN, injected NAD, growth hormone, testosterone, taurine, nattokinase, metformin, berberine, and nootropics.Throughout the episode, he emphasizes that no supplement has been shown to reproduce the effects researchers are attempting to achieve through partial epigenetic reprogramming—and that many of the most dramatic claims circulating online remain unsupported.Editorial Note:ER-100 is an investigational therapy. Authorization to begin a clinical trial does not mean the treatment has been proven safe or effective, nor has it been approved for clinical use.The Phase 1 study is primarily evaluating safety and tolerability, with additional measurements of visual function. Results from mice and nonhuman primates do not establish that the therapy will restore vision or reverse biological aging in people.The discussion of supplements, prescription medications, hormones, and lifestyle practices reflects the speakers' personal views and interpretation of the research. It should not be treated as individualized medical advice. Prescription drugs, hormones, supplements, and experimental longevity treatments should be discussed with an appropriately qualified healthcare professional.What You'll Learn:How partial epigenetic reprogramming differs from completely resetting a cell into a stem cell.Why researchers selected three Yamanaka factors—OCT4, SOX2, and KLF4—instead of using all four.What ER-100 is designed to do and why the first human trial focuses on the optic nerve.How doxycycline acts as an external switch controlling when the therapeutic genes are expressed.What Phase 1 researchers will measure and what would need to happen before ER-100 could become an approved treatment.Why the eye provides a useful starting point for testing cellular rejuvenation.What animal studies suggest about restoring vision, memory, liver function, joints, and skin.Why delivering rejuvenation therapies throughout the body is more difficult than treating one localized organ.The difference between oral NMN supplementation and intravenous or subcutaneous NAD.What current research does—and does not—show about growth hormone, testosterone, taurine, metformin, and berberine.Why muscle, exercise, sleep, diet, glucose regulation, and inflammation remain important even if rejuvenation therapies eventually succeed.How Sinclair's laboratory is searching for pills and small molecules that could mimic epigenetic reprogramming without gene therapy.Timestamped Chapters:[04:53] The First Human Trial Begins David discusses ER-100, FDA authorization, and the treatment of open-angle glaucoma and ischemic optic neuropathy.[06:52] What Are the Yamanaka Factors?How reprogramming genes can reset cellular instructions—and why using all four factors can be dangerous.[08:56] Reversing Vision Loss and Memory Problems in AnimalsDavid describes studies involving the eyes, brain, skin, kidneys, liver, and age-related cognitive decline.[10:09] Why Four Factors Can Cause CancerThe difference between restoring youthful function and erasing a cell's identity completely.[10:54] The Three-Gene BreakthroughHow Sinclair's student Yuancheng Lu persisted through years of failure and identified the OSK combination.[12:03] Pulsing the Genes vs. Leaving Them ActivatedEarlier four-factor experiments required intermittent activation, while OSK showed a different safety profile in animal eyes.[13:36] The Doxycycline Safety SwitchHow clinicians may use an antibiotic to activate and deactivate the therapy after it has been delivered.[14:51] Treating the Cause Instead of the SymptomsDavid argues that restoring younger tissue function could allow the body to repair damage associated with age-related disease.[16:02] Why the Trial Starts With the EyeLocalized delivery reduces systemic exposure and makes visual changes easier to observe and measure.[16:50] Can the Therapy Reach the Brain and the Rest of the Body?The challenges of distributing gene-based treatments evenly across organs and through the blood-brain barrier.[18:25] What the Phase 1 Trial Will MeasureSafety, tolerability, visual function, and the possibility of an accelerated development path.[20:36] Expanding Beyond GlaucomaWhy each organ may require a different delivery vehicle—and how the liver could become another early target.[21:38] How Shinya Yamanaka Found the Original Four FactorsThe trial-and-error process that turned adult cells into induced pluripotent stem cells.[22:38] How ER-100 Is DeliveredDavid explains the OSK genes, the AAV delivery system, doxycycline activation, and why manufacturing is expensive.[25:21] When Could the Treatment Become Available?David gives his most optimistic development timeline and discusses parallel programs targeting other organs.[27:31] NMN, NAD, Sirtuins, and the Information Theory of AgingHow declining NAD levels may affect cellular defenses and the regulation of gene expression.[31:34] Oral NMN vs. Injected NADWhy David believes oral supplementation currently has more rigorous evidence than NAD injections.[32:20] Longevity Misinformation OnlineDavid explains why he is restarting his show and warns against confident recommendations unsupported by research.[32:41] Growth Hormone and LifespanWhy growth hormone may improve certain functions but has not been shown to slow aging or extend human life.[34:05] Testosterone, Muscle Mass, and Healthy AgingPotential benefits for maintaining muscle—and why testosterone alone should not be considered a longevity treatment.[36:01] Taurine, Nattokinase, and Changing Your MindWhy David stopped taking taurine regularly and what prompted his interest in nattokinase.[37:30] David's Current Diet and His 86-Year-Old FatherLower meat and cheese consumption, little alcohol, exercise, supplements, and tracking inflammation through biomarkers.[39:33] James's Longevity RoutineLimited processed sugar, intermittent fasting, reduced meat and alcohol, and prioritizing eight hours of sleep.[40:07] Why Sleep Cleans the BrainThe relationship between sleep, waste removal, protein accumulation, cognition, and dementia risk.[40:33] Metformin as a Possible Longevity DrugWhy a medication developed for type 2 diabetes remains central to aging research.[41:41] Berberine and Mitochondrial FunctionWhat clinical studies suggest about glucose regulation and why David sometimes alternates berberine with metformin.[43:10] Modafinil, Adderall, and NootropicsPossible short-term benefits for focus weighed against uncertainty about long-term consequences.[43:43] What Comes After the Eye Trial?Potential applications involving the liver, lungs, kidneys, joints, brain, and other age-related conditions.[45:14] Can Rejuvenation Make Skin Look Younger?David describes unpublished work involving human skin, wound healing, and orally delivered compounds in mice.[46:17] Beyond Gene Therapy: A Rejuvenation PillHow AI and chemical screening may help reproduce the effects of early embryonic reprogramming more cheaply and simply.[47:31] When Could Chemical Reprogramming Reach Humans?David discusses the preclinical safety work and the uncertainty surrounding future human studies.[48:11] The Lifespan Community and FoundationDavid introduces his new show, longevity community, and support for scientific research.Additional Resources:ER-100 Phase 1 Trial — ClinicalTrials.govOfficial registration for the first-in-human study evaluating ER-100 in open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy.Life Biosciences: FDA Clearance for ER-100The company's January 2026 announcement that the FDA cleared its Investigational New Drug application.Life Biosciences: First Participant DosedThe June 2026 announcement marking the start of dosing in the Phase 1 trial.“Reprogramming to Recover Youthful Epigenetic Information and Restore Vision” — NatureThe 2020 mouse study reporting that OSK expression restored youthful epigenetic patterns, promoted nerve regeneration, and reversed vision loss.The Sinclair Lab at Harvard Medical SchoolResearch, publications, laboratory members, and information about David's work on the biology of aging.Lifespan: Why We Age—and Why We Don't Have ToDavid Sinclair and Matthew LaPlante's 2019 book about the biology of aging and emerging longevity research.LifespanDavid's longevity show, research magazine, community, and information about the Lifespan Foundation.NMN Human-Trial Review — PubMedA review of the safety evidence and proposed effects of nicotinamide mononucleotide in human clinical studies.NMN and Physical Performance — PubMedA systematic review examining randomized trials of NMN and physical-performance measurements.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ebook: https://drive.google.com/file/d/1AUsxg05dXkKFeAa64kC0u16XynnSx68o/view?usp=drive_link Episode Description: Every peptide conversation right now is about GLP-1 drugs, BPC-157, and TB-500. Nobody is talking about the one with 50 years of published research that your body is already making and losing as you age. GHK-Cu is a naturally occurring tripeptide that declines by 60% between the ages of 20 and 60. That decline tracks directly with the loss of skin elasticity, slower wound healing, thinning hair, reduced collagen production, and rising inflammation. In randomized controlled trials it has outperformed Rogaine for hair growth, shown a 55% reduction in visible wrinkles, and been documented to positively affect the expression of over 4,000 human genes. Dr. G calls it his favorite peptide, and his partner uses it on her face every day. In this episode, you will learn:  • How GHK-Cu works as a copper delivery vehicle at the cellular level, why it modulates gene expression across 31% of the human genome, and what that means for tissue repair, inflammation, and biological aging  • The head to head randomized controlled trial where GHK-Cu outperformed minoxidil for hair count, follicle size, and the active growth phase of the hair cycle  • Exactly what to look for when buying GHK-Cu cream, why the peptide is chemically fragile, what packaging and pH range to require, and the red flags that tell you to walk away from a product Timestamps: 0:00 - Intro 1:44 - What GHK-CU Actually Is and How It Was First Discovered in 1973 3:10 - Why a 60% Decline in GHK-CU Between Ages 20 and 60 Tracks Directly With Aging 4:40 - What Makes GHK-CU Different From Every Other Popular Peptide 6:00 - How It Stimulates Collagen, Elastin & the Extracellular Matrix 7:15 - The Human Trial Showing a 51% Increase in Collagen Density From Topical Application 8:00 - The 4,000 Genes GHK-CU Affects (And What the Broad Institute Found) 9:30 - Anti-Inflammatory Effects: Why This Matters for Biological Aging 10:30 - Wound Healing, Angiogenesis & Tissue Repair Across Skin, Bone, Gut and Liver 11:30 - The 2022 RCT: 55.7% Reduction in Visible Wrinkles After 12 Weeks 12:30 - Hair Growth: Outperforming Minoxidil in a Head-to-Head Randomized Trial 14:30 - Why the Lower Dose (50mg/ml) Outperformed the Higher Dose 15:30 - Safety Profile, Contraindications & the "Copper Uglies" Explained 17:00 - How to Buy GHK-CU: Concentration, Packaging, pH & What to Avoid Learn more about your ad choices. Visit megaphone.fm/adchoices

Early signs of dementia can show up years before a diagnosis. Discover 31 scientifically proven dementia prevention strategies designed to preserve cognitive function and support long-term brain health.0:00 Introduction: What is dementia?0:42 How to not get dementia3:03 Stomach acid and dementia signs5:40 DHA to improve cognitive function7:20 Aluminum and brain function9:45 Gum health and dementia11:04 Hypoxic training for dementia prevention14:51 Keto and intermittent fasting for dementia prevention16:16 Genes and dementia