Podcasts about genes

Jennifer J. Brown is a scientist, a writer, and a mother who never got the luxury of separating those roles. Her memoir When the Baby Is Not OK: Hopes & Genes is a punch to the gut of polite society and a medical system that expects parents to smile through trauma. She wrote it because she had to. Because the people who gave her the diagnosis didn't give her the truth. Because a Harvard-educated geneticist with two daughters born with PKU still couldn't get a straight answer from the very system she trained in.We sat down in the studio to talk about the unbearable loneliness of rare disease parenting, the disconnect between medical knowledge and human connection, and what it means to weaponize science against silence. She talks about bias in the NICU, the failure of healthcare communication, and why “resilience” is a lazy word. Her daughters are grown now. One's a playwright. One's an artist. And Jennifer is still raising hell.This is a conversation about control, trauma, survival, and rewriting the script when the world hands you someone else's lines.Bring tissues. Then bring receipts.RELATED LINKS• When the Baby Is Not OK (Book)• Jennifer's Website• Jennifer on LinkedInFEEDBACKLike this episode? Rate and review Out of Patients on your favorite podcast platform. For guest suggestions or sponsorship inquiries, visit outofpatients.show.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

BOSSes, Anne Ganguzza is joined by her superpower co-host, Lau Lapides, to discuss a critical issue in the voiceover industry: brand alignment and navigating controversy. Sparked by the American Eagle/Sydney Sweeney campaign, the hosts explore how a voice actor's ethics and personal brand are intrinsically linked to the clients they represent. They emphasize that in the age of social media, protecting your digital reputation is non-negotiable for long-term career success. 00:00 - Anne (Host) Hey bosses, Anne Ganguzza, you know your journey in voiceover is not just about landing gigs. It's about growing both personally and professionally. At Anne Ganguzza Voice Productions, I focus on coaching and demo production that nurtures your voice and your confidence. Let's grow together. Visit anneganguzza.com to find out more.  00:25 - Speaker 2 (Announcement) It's time to take your business to the next level, the boss level. These are the premier business owner strategies and successes being utilized by the industry's top talent today. Rock your business like a boss a VO boss. Now let's welcome your host, Ganguzza.  00:47 - Anne (Host) Hey everyone, Welcome to the VO Boss podcast and the Boss Superpower Series. I'm your host, Anne Ganguzza, along with my awesome superpower co-host Lollapetas.  00:56 - Lau (Guest) Hello, Annie, it's so good to be back. I love being in this Zoom room with you. Or it's not Zoom, but it's Riverside, but I love being in this space room with you. Or it's not Zoom, but it's Riverside, but I love being in this space with you, I know I look forward to it.  01:10 - Anne (Host) We get to see each other and it's been so long it's fabulous when we get back together because we have so much to catch up on. I know, I know oh my gosh.  01:19 - Lau (Guest) By the way, I love your outfit today. You look great.  01:23 - Anne (Host) Why thank you my, my jean shirt or my denim shirt? No, what's really cool about this is this is kind of well, I should say it's it's. It's deceiving, maybe because it looks like it's denim but it's actually like French Terry, and so it's super, super comfortable. But you know, speaking of jeans, I was going to say what color are your jeans.  01:50 Well, you know, I have good jeans and advertising campaigns for our businesses. I mean gosh, it's all over the news. I mean the American Eagle campaign with Sydney Sweeney. I mean, you know, she's got good jeans, and so it's a really interesting debate. I think it's something that we could absolutely relate to our own voiceover businesses in terms of associating with now, first of all, like associating with a brand that may or may not be controversial or may or may not be on the side of you know where your feelings align. I think that would be a really, really interesting topic.  02:30 - Lau (Guest) Lau I love that topic because we hear that word floating in the industry now for quite a while branding. Branding is connected to marketing, is connected to selling right and how you represent yourself and who you're connected to. That helps you represent yourself as well. And making some of those concerted decisions on who you want to be attached to and connected to, that really help you design your ethos of your business.  02:58 - Anne (Host) Well, they can help you. They can help you be successful in the industry, or maybe not. They can help you be controversial in the industry, or maybe not. They can help you be controversial in the industry. It's such an interesting. Now you know one thing about that campaign for me, when I first saw it, I didn't think anything of it, because I am a woman of a certain age and I remember the Jean campaign with Brooke Shields and Calvin Klein, and I just remember it, with Brooke Shields and Calvin Klein, and I just remember it, you know. And so, as a girl in, I think it was in elementary or high school. I can't remember when that came out, but it was the 80s, right? All I know is that I wanted a pair of Calvin Klein jeans because I wanted to look like Brooke Shields. Now today, didn't we all did not we Right?  03:41 No, I thought nothing of it, right, I thought nothing really horrible of it. But then it did become controversial because obviously she was, you know, she was young when she did that ad and it was a little bit sexually, you know, promiscuous, some people would say. And so, you know, today that type of advertising wouldn't fly and I think people are comparing Sydney Sweeney with that, because of she's got good genes, you've got an attractive female and a pair of jeans, and you know, of course, american Eagle says you know, it was always all about the genes, it's not always not about the, not about the misconception that jeans J-E-A-N-S is similar to G-E-N-E-S, so there's a lot to unpack there.  04:25 I don't know how did you react to it when it first came out? What were your thoughts?  04:29 - Lau (Guest) Well, you know what's so funny about the Brooke Shields thing that you bring up? That's the first thing I thought of is that everyone who's outraged about it is not old enough to remember the Brooke Shields and that's what they were really copying. I think that was a copycat from 45 years ago Going back to the old let's sell.  04:45 Yeah, but if you remember, annie, it was there was another controversy hooked on to Brooke Shields at that time, based on that commercial, because that was right around the time that she had shot Blue Lagoon, blue Lagoon, yeah, and she was only like 11, 11 or 12.  05:05 - Anne (Host) I think it was 13.  05:05 - Lau (Guest) Well, by that time she was about 13. But she was still very young and the mother was managing her and so there was a huge blowup and controversy about this young girl doing these so-called sexually explicit commercials about my sexuality and my body, about my sexuality and my body. And I remember thinking, and when I saw it again I thought wow, how did she get those jeans on without showing us anything, right in front of us, Like I was amazed and, as a young girl, I yeah, it was a Cirque du Soleil act.  05:35 It was amazing. Yeah, you know, as a young girl, media is so influential right.  05:41 - Speaker 2 (Announcement) So, influential.  05:41 - Anne (Host) The thing is that, as voice actors, we really have a part in playing into the media, right, because our voices are representing brands, and for me at the time, I didn't consider anything wrong with it. All I know is that I wanted to look like Brooke Shields in those jeans and therefore I wanted the jeans. And I'll tell you what it was an expressly popular campaign that made Calvin Klein a ton of money, a ton of money.  06:09 - Lau (Guest) But if you look at it now as an adult and you listen from a voiceover perspective, her voice was very, very young very kidlike and very straightforward. She was trying to be, if anything, a little bit smart or intellectual versus overly sexy and centralized, but yet the perception, the visual right Was that was that.  06:34 - Anne (Host) That's exactly it. So there's a lot of, there's a lot of things there, and if you were the voice of a campaign that was controversial, right would. If it was something you believed in or didn't believe in, is that something that, as a voice actor, would you accept? And I think, or an actor, I mean any kind of role right? Do you accept those roles if they align with your belief system or your morals or your ethics or whatever that is, and how can it propel your business forward or not?  07:07 I mean, there's just so much that we have choices in, and as well as influence in, as voice actors, and we think sometimes we're hiding behind this microphone, but no, we're still a very intricate part of a media campaign. And so, really, as a voice actor, how do you decide? Really, is you know, oh, this could really propel my campaign if I decide that I want to align with this brand and be the voice of it, or sometimes it's not even about being the voice of it. It's maybe working with that brand in any capacity. You know, how is that going to affect your business? Because people have opinions, people always have opinions, and gosh aren't they all over the place.  07:56 - Lau (Guest) Now that social media is prevalent, they're the Wild West we like to call it right, Annie, it's the Wild West.  07:59 And I would say in my mind it's likened to all the people, not just women but men too. In my mind it's likened to all the people, not just women but men too, but certainly all the women, who have said for many years you know, I am interested in doing romance novels, exotica work, triple X, adult swim as a voiceover talent, but I'm concerned about how my business is going to be viewed. I'm going to use an AKA, an alter ego, another name, another business name, and so I think that voiceover talent have been making these decisions for a very, very long time. Even though we don't have the visuals for the voiceover talent, we may have the visual for the work and so for the work itself may give visuals and vocals that are not aligned with the talent's vision of their business, and sometimes you don't even know.  08:49 - Anne (Host) Sometimes you don't even know, right. I mean you can tell a lot by the context of the script sometimes, but sometimes you can. You don't know where that's going to end up. And again, now that makes me think of, like, you know deep fakes and AI and you don't know where your voice is going to be used. But if you are, you know, an active participant and you are aware, I think really the best thing you can do if these things are concerning to you, right, the more you know, the more you're educated, the better off you're going to be, because you can make those decisions to determine if you want to be aligned.  09:24 I mean there have been careers ruined by, you know, wrong brand alignment, and gosh knows with today's you know political climate. I mean it comes down to and you know what, laura, it comes down to if you think about it. We're in a business. We need to make money, right, and guess what? So are companies that are advertising, right. They're in the business to make money and so a lot of times our decisions are based on money. Yeah.  09:52 - Lau (Guest) Wake up, smell the coffee right, and it's like who is to judge what one person or one brand identity or one company should or shouldn't be doing. It's really in the eyes and ears of the audience. It's really the perception. So, as many people really disagree, fervently disagree and are angered and outraged by that particular American Eagle campaign, you have a mass swath of people who are buying everything.  10:24 - Anne (Host) That gene that she is, they can't keep. I'm just saying or buying everything that gene, that gene that they can't keep it on the proverbial shelf Exactly.  10:29 Right, Exactly so yeah, and it's interesting because I read a couple of. I read a couple of articles about it and they, of course, american Eagle says it's all about the genes. It's always been about the genes and in reality it kind of is like a return back to marketing. You know, marketing for the last few years has been very concerned with, of course, the shift, notice how the shift in cultural trends, right to making sure inclusivity, diversity, you know, every body type is shown and everybody is represented, which I thought was great. I mean I love that. But apparently, like, if you're in the business, I mean, did it sell? I thought it did.  11:09 Personally, I aligned with it better and I bought, I consumed, just like I did before. However, there is a a huge, there's a huge another aspect to this to unpack, about influencers, right, I mean, in reality, I mean she's a famous actress, right, and so just like Brooke Shields. So if she's going to wear these jeans and feel good in them and look good in them, then that's going to really entice other people to buy and you know, or not, right? And If they, I mean how many times? Lau and I I have very strong ideas about like companies and what they do with their money. So like if they're known to, you know, I don't know, do bad things. I will not support of things that companies do behind the scenes and therefore, when I do find out, I then have a choice, to make a decision whether I want to consume that, you know, buy that or not. And I think that, again, as a consumer and as a voice actor, the more educated we can be, the better decisions we can make to determine if we want to align with that.  12:21 - Lau (Guest) I would totally agree and I would say the irony to me about talking about influencers online is why are they called influencers? Yeah, yeah, they're called influences because they have powerful influence over mass swaths of people who want to look like them, sound like them, live like them, whatever. Of people who want to look like them, sound like them, live like them, whatever. So if we were to make a value judgment, we would have to make it evenly across the board between network television and social media and voiceover and radio and TV, that that is just a no-go, which, of course, no one's going to do. We're not going to do that because you know it's a free country and people are going to run their businesses how they run their businesses girls on Instagram to get that facelift or to get those eyebrows or to get those lash extensions, to feel good about who they are.  13:27 - Anne (Host) Well, oh no, okay, you bring up a really important point here, right To feel good about who you are. So what I do because you know I do a little bit of fashion influencing- I know you are an influencer, actually.  13:39 - Lau (Guest) My well, oh my goodness, put your influencer hat on.  13:42 - Anne (Host) So my influencer hat is and I've been, I've been multiple sizes, I've been big and I've been small, right, I mean, I don't know, I've never considered myself small, but that's a whole nother podcast. So, depending on the size right, I followed different influencers. I found and for the most part, if you think about it, when I was a little bit bigger, I had an influencer who I loved her because she was bigger and she was confident and she was beautiful. And I said, gosh, if I could just be confident. And you know, and as a matter of fact, people in my life I've known, I'm like gosh, she's bigger and she's confident. I wish I could be confident like that. I could be confident like that. And then when I, when I started to lose weight, then I it's funny because I switched, following the one influencer who her body type was a little bit bigger, to an influence it was a little bit more my, my body type size, or maybe even smaller, because it was then helpful, it was motivating for me, or inspiring to me.  14:36 And so, in reality and in every instance, right, the influencer made me feel better about myself. Right, I was either motivated or inspired. To well, people are going to say it might be healthy if you say, oh, I want to look like them. But in reality, when it came to my weight, my body size, it was more about becoming healthy. I needed to become healthy, right. And yeah, the clothes were pretty. I didn't have that option with these clothes at this particular size. So, yeah, there was something inspirational and motivational. And then there was the girl who I still follow. She's a bigger girl who is just beautiful at whatever size she's at, and it's really the message that she's saying. That's really the most important thing.  15:17 - Lau (Guest) But I have a question about that, annie, and I know we're getting a little farther away from the voiceover aspect, but from a performance and business aspect, voiceovers need to be thinking about all of this and how you represent your brand and how you think about what you do. Well, absolutely, my question is you have a lot of these people, including, like Lizzo, for instance she was the first one that came to my mind, yeah who made it very public that they lost a ton of weight and that they are very happy they did that and very happy that they're healthier and very happy at whatever they're at.  15:51 - Anne (Host) Yeah.  15:52 - Lau (Guest) So it makes you question well, wait a second, is this for branding sake, to have those brands out there because they know, like a big part of the population is, say, has a certain look or a certain size or a certain sound? Well, yeah, the biggest demographic, the biggest demographic, right? Yeah, versus the reality of the person actually feeling good in their life, I'm going to argue that they're performers and they're performing and that many of them don't feel good about some of the choices they've made in their life and therefore they go and change it. Or their company representatives say you need to change this brand because it is not resonating with the majority of our audiences and we will never know.  16:38 Never know how much influence comes from which direction. We will really not know, that right.  16:44 - Anne (Host) Absolutely. I mean and again this is I mean for bosses out there if you think we're going off topic, in reality we're not, because we're not talking about marketing and advertising, which directly affects us. I mean, that's where we I mean our voices are representing brands that have fluctuations in the way that they advertise and in the way that they market their products, and it's important for us to understand where it's headed, where the trends are and really what is it that matters. And then, what is it that matters to you as an actor, being a part of that campaign, resonating with a brand that may or may not be controversial? Right, Brands change.  17:26 - Lau (Guest) This is where you have to forgive yourself they shift and change trends over time, because that's the natural state of being a human being, is that you age, you change, trends change whatever. Another one that comes to my mind one of my favorite original rappers and then became actress was Queen Latifah. Yeah, yeah. Who I loved for so many reasons. Yeah she's awesome Right.  17:50 - Speaker 2 (Announcement) Rubenesque woman beautiful woman.  17:52 - Lau (Guest) Well, she went on a whole campaign I can't remember what it was, whether it was Jenny Craig or Nutrisystem or whatever it was, but she became the brand ambassador of them to lose weight and she had trouble doing it and she never reached the target weight. When she didn't, they dropped her. Yeah, yeah, okay. So my point is was that her and it made you feel like, it made me feel like you know, when you use Tide or use a laundry detergent and then, all of a sudden, you've been using it and it's been good for years, and then it's like no, all new developed. You think, what have I been using that whole time? It wasn't really good. That's how it made me feel.  18:31 - Anne (Host) Well influencing you know and marketing advertising, influencing in their way influencing right as opposed to, and I think that's why influencers became really popular, because it was real people, it wasn't companies. Well, it was the illusion of real people, right?  18:47 Well, they are real people Right right, oh look, I'm not being paid for this but a lot of times, influencers, they get a little bit of a cut. I mean I, you know, hey, I got a little bit of a cut. I'm encouraged to, you know, try this top or this, you know, this pants set or whatever, and then talk about it so that I can get a little bit of a break or a deal. But I creatively love to curate outfits and, to be quite honest, the amount of time I spend at this point because I don't do it full time the amount of time that I spend, you know, putting together videos and stuff, it takes a lot of time. That's my, that's like a, that's a day of my weekend in reality, and I don't make I don't make half as much money as I do when I'm doing voiceover. So for me that's just like a passion project.  19:31 But what is it that voice actors you know need to do? I mean, I think that you either don't realize that you are an intrinsic part of a brand that could or could not be, you know, I mean, you probably know if they're controversial. It's the same thing with political voiceover, Right, we talked about this like not so long ago. What's you know? Are you on a particular side of the fence? Are you? Is your voice, your voice being speaking things that align with your, what you believe in and your morals and your ethics? Or are you just voicing things to make money, because it happens to be something that pays the bills?  20:09 - Lau (Guest) Right and really paying attention to what your audience is identifying your value as. Like I can come in and say, well, I'm going to provide this, I'm going to do this, but I may not have the calling for that. I have to pay attention. Where is the calling of the audience?  20:27 And then go to the. If I want to go to the full extent of that brand, give them awareness of what it is, awareness of my, you know, professionalism, my ethos in it. Whatever that is, it's not always what I'm starting out to be is what it's going to be. I see that all the time like a mismatch of brand knowledge. Someone would say, well, I do this all the time, I play this all the time and I say, right, but what are you being hired for? What you're being hired for might be very different than what you do in your side life.  21:01 - Anne (Host) And if you think about it, like if you align yourself with a style of voiceover that is, you know, has a message, right, that may or it on levels with brands that I've been associated with, where, if you're not careful and you know I mean with the VO Boss podcast, right, if you're not careful people will associate you with those brands as well, and you know that can be detrimental to your career, to your livelihood, and that is something it's sometimes. It's not an easy decision. It's not an easy decision to make. It's not an easy decision.  21:42 - Lau (Guest) It's not an easy decision to make. It's not an easy decision. You have to realize you're performing a part. So whenever you are in that what I call the awareness zone that's like the industry awareness of who you are Like I feel like I play two parts. One is the real person in the larger world, who may or may not know me, and then the person, the mama, who knows me, who people know me in the larger world, who may or may not know me, and then the person, the mama, who knows me, who people know me in the industry. And when I play that role, I know I'm always to some degree on, you're always on and having that awareness that there is a performance value to what you do. How?  22:15 - Anne (Host) interesting because your brand, since I've known you, has evolved into Mama Lau, which you know what I mean. Because I want to say it's because I started calling you Mama Lau, because that's what I called my mother, and then it turned into Mama Lau, but now as Mama Lau, known as Mama Lau in the industry. Right, you now need to be considerate of. Okay, what does this brand speak about me? And if you were to do something, that would not be Mama Lau.  22:42 - Lau (Guest) Right, so I'm not going to go to Vegas and become a stripper anytime soon. Are you going to?  22:47 - Anne (Host) be an erotic. I mean, would you be an erotica audiobook narrator? I mean, well, maybe not under Mama Lau but, here, you are here you are with. Unless you're going to be a character voice, right, here you are, I know your voice. And unless you're going to be a character voice and I don't recognize that voice, right, our voices are recognizable.  23:07 I mean, some of us have immediately, like I know, this person's voice from you know long you know, far, far away, I can tell that voice and I have that with some of my students that have distinctly unique voices, right, I'm thinking they probably can't go into you know erotica character work if they don't want to know other people to know about it. Yes, you know, if you want other people to know about it, that's fine. But for you, under that brand, you have to. There's a responsibility to that brand, right?  23:34 - Lau (Guest) Yes, there is.  23:34 - Anne (Host) In what you do. It reminds me of. It reminds me of oh my gosh, who was it? Who was it? He was a comedian. He was fired in 2011 due to offensive tweets he made about the Japan earthquake and the tsunami. And it is, oh my gosh, gilbert Gottfried. There you go.  23:50 - Lau (Guest) Oh wow, how could we not?  23:52 - Anne (Host) remember that, yes. I know right Gilbert Gottfried.  23:55 - Lau (Guest) I didn't know that.  23:56 - Anne (Host) Yeah, oh yeah, and it was. It was. That was, I think, when it first, at least when I was in the industry, when it first became evident that social media and what you do outside of your job in voice acting, will have a direct effect, if it's offensive enough, right On your job. And you know, nowadays people have to be careful on social media what they're posting. And because companies can now go check out your social media, because companies can now go check out your social media, and so for you as a voice actor, again, it has to come to mind that if you are known, or if you are known in social media, now your actions, if people were to look you up on social media and find that you're associated with a brand or find that you are, you've done something that I don't know is not something that aligns with their ethics right, it can affect your business.  24:52 - Lau (Guest) So in a way, annie, it's kind of like we're blurring the lines of our real reality of living a life as a person, with our business and our performance career, that there is kind of that expectation that you sort of represent it all of your life, all of your life, and you're not going to go through anything. That's antithetical to that image that is being put out there, which I mean. For me it's easy because I'm kind of like, I'm a mama type anyway, but for the average person I think that would be hard, that would be a challenge.  25:27 Mama Lau as mama Lau would not go to a Coldplay concert and get yourself caught on the probably not. I'd be the person standing outside with food, waving my hand, going what did you do in there? What did you do?  25:37 - Anne (Host) And we should bring that up, because yet there's another like CEO of you know, of a company, and then the director of HR, the director of the people I forget what they call it now. I'm like director of HR, no people, ceo of people. Forgive me for not knowing what her title was. She was HR, wasn't she?  25:55 - Lau (Guest) The head of HR. Yes, Like top HR, you know? Executive.  26:00 - Anne (Host) I think PMO is a people. I forget what it is, but anyways, see it, you know. So, really, if you think about it, what did that do those actions do to the brand? Right To the brand. Yes, they say all all, what is it? All publicity is good publicity, but do you think that this was good publicity for the company?  26:24 - Lau (Guest) No, no, I don't either. I don't think there was any redeeming value to that and that felt to me it could have been happenstance, but it felt like a setup. It felt like someone tipped someone off to put them on the jumbotron.  26:37 - Anne (Host) Oh interesting, I didn't think that it didn't just feel random.  26:40 - Lau (Guest) There was like, like, how many people were there?  26:44 - Anne (Host) 50,000? I don't know. I think I, I didn't think it, I don't think they were set up, I mean, unless you have somebody in the company that's like. Well, I mean, first of all you have to, you have to know the person that's, you know, focusing on the Jumbotron and say, oh my God, wouldn't it be funny if you know I hate that guy or whatever? But think about it?  27:01 - Speaker 2 (Announcement) I don't know.  27:02 - Anne (Host) Your actions in life right can be directly affected these days because of social media, because of the now back in the day when I had to walk to school 10 miles up a hill in the snow. When there wasn't social media, it was a little easier to get away with, I would say, indiscretions like that.  27:24 - Lau (Guest) But now, maybe even now with being a voiceover talent. You've got that anonymity to some degree.  27:31 - Anne (Host) But not as much anymore. I'm saying not as much anymore, remember, because voice actors, we're all about social media, aren't we? Because, guess what we need to get work and what are we doing? We're trying to showcase're all about social media, aren't we? Because guess what we need to get work and what are we doing? We're trying to showcase our brand on social media, and when you do that, you really have to be prepared for repercussions. If you are going to voice a campaign, associate yourself with a brand that may be controversial, and you know something that is a concern for your business. That may not have been so much of a concern maybe 20, 30 years ago.  28:06 - Lau (Guest) It's true, because I think with probably the third generation now, or what would we say, maybe the second generation now, millennials and Gen Zers, who are digital natives, growing, up online on social media like their life online on social media like they didn't see the commercial.  28:23 Their life- is on social media. So their lines are very blurred, like I would say, arguably our generation x not as blurred like I know. When I was younger I used to think, oh, the Brady kids are really like that. Now I realize they're separate people, right, they're separate people than what they did in the sitcom. But nowadays it's like oh, everyone thinks that anything you do online is you, is really you, and so it puts a lot of pressure on those people to say okay, am I in alignment with the kind of brand that I want to have out there or not?  29:02 And a lot of people will say well, you know what do they say? All good, all press, bad press, negative press is still good, press, it's still good. I don't know about that. I don't know about that. I don't think that's true. Yeah, I don't think that's true.  29:15 - Anne (Host) I mean in a way. I mean in a way who said?  29:19 - Lau (Guest) that. Beyonce, who said that Someone big said that I don't even remember, but in a way, american Eagle is benefiting from the controversy.  29:27 - Anne (Host) However, there's really good arguments on either side of it. Again, they're promoting to a crowd you know who are their best sellers. Do you know what I mean? Because, as I and you also talked about in the beginning, we have a certain familiarness with advertising from 30 years ago, right 40 years ago, and so for us, maybe that ad was like oh okay, I didn't think anything of it, but then all of a sudden, because of the younger generation, right, who are like hey, what is this? Or you know, or why, especially with political things going on, what do you mean? Genes like G-E-N-E-S Is that? Then it became a political thing. So I think that we have to be really, really careful, as voice actors on social media, to make sure that we're aware, be aware, educate yourself and be aware of what your voice, what your presence, what your social presence means to your business.  30:33 - Lau (Guest) And I also would add on to that, annie, that we just had a discussion because my group was in New York showcasing of actors and I was really tough, talk about mama, tough. I was really tough and saying listen, I'm just going to tell you this right now If you don't go into your social media right now, before you audition for those agents, those casting directors, those producers, and clean it up and scrub your stuff, scrub it.  30:57 Get reputation defenders. Do whatever you need to do to scrub it. Keep your ideas and ideals separate, because you don't want to alienate people and their whole audience before you even meet them and audition for them, do you? I mean, do you to be a really good note to leave on Digital Digital?  31:25 - Anne (Host) We are digital. We are digital.  31:27 - Speaker 2 (Announcement) Your footprint's there.  31:28 - Anne (Host) Digital is traceable, just saying Digital is traceable, you are. Have you ever tried to? And again, we've never really covered this in depth, but if you think about it, if you ever tried to make a comment and then delete it and then it didn't really delete or did, how many people took a screenshot of that? Yeah, you know, before you deleted it.  31:48 So again, things are digital and things, and because we've gotten again on your phone, on your computer, just assume that people are tracing and I know, yes, you can get it's not right and I get that, but just assume and just you know, honestly, just be aware, be aware and protect your business, protect your voice, protect your business and protect your bossness. Guys, be a bossness.  32:16 - Lau (Guest) And I'll leave on this note in saying yes, and I'll piggyback by saying, even just for who you are as a person, be happy and content with the brand you're creating. Because, you're going to have to live with that for a long time. As long as you have your business, you'll have to live with it.  32:34 - Anne (Host) I have people.  32:35 - Lau (Guest) Annie when I go to a conference or something screaming across the room hey mama, how are you? If I didn't like that, I didn't want that, I'd have to change it. I'd have to really change it and make a concerted effort to do that so be happy with what you're selecting and what you're choosing and what your audience is giving to you and, if not, strategize elsewhere, redirect it.  32:59 - Anne (Host) Good stuff, good stuff, amazing Bosses. We would love to hear your thoughts honestly. So you know, write us at theboss, annaviobosscom. We'd love to hear from you right in our community Facebook page. We'd love to hear your thoughts on this. So, Lau, it's been amazing, amazing, as always. Big shout out to our sponsor, ipdtl. You too can connect and network like bosses. Find out more at IPDTLcom. Bosses have an amazing week and we'll see you next week.  33:30 - Speaker 2 (Announcement) Bye, see you next time. Join us next week for another edition of VO Boss with your host, anne Ganguzza, and take your business to the next level. Sign up for our mailing list at vobosscom and receive exclusive content industry revolutionizing tips and strategies and new ways to rock your business like a boss. Redistribution with permission. Coast to coast connectivity via IPDTL.     

On Healthy Waves, host Avik Chakraborty sits down with Daniel Tausan (founder, Timeline Sciences; stem-cell biology, UBC; former Canadian National Water Polo athlete) to challenge quick-fix health culture. Daniel explains why rebuilding health starts at the foundation—habits, movement, and precise language—rather than supplements or shortcuts. We get into interpreting bloodwork for everyday people vs. trained bodies, how to train for longevity (not just performance), and why pain is a signal to engage with—not numb. If you want a direct, science-grounded path to durable health, this conversation delivers practical clarity you can use today.   About the guest  : Daniel Tausan is the founder of Timeline Sciences. With a background in stem cell biology and predictive health analytics, and experience as an athlete and coach, he helps people align actions with biology to build resilient, long-term health.   Key takeaways: Health rebuilds from fundamentals: daily choices that align biology, mindset, and context—not surface fixes. Early asthma, allergies, and gut issues pushed Daniel to study regeneration and physiology through practice, not theory alone. Modern exposure and information overload make clarity essential; use science to navigate, not to chase trends. Pain is data. Don't rush to numb it; investigate and act so it can guide repair. Movement is the “human tax.” Train for a lower resting heart rate, better lung capacity, and elastic neuromuscular patterning for quality longevity. Read labs in context: civilian, health-challenged, or trained/resilient bodies live in different physiological ranges. You don't need an athlete's mindset to be healthy. Favor honest feedback, sustainability, and enjoyment to prevent injury and promote adherence. Precise language shapes mindset and outcomes. Define what you mean by “science,” “spirituality,” and “health” to choose better actions. Genes are rarely destiny for most people; many outcomes are modifiable through behavior and environment. Think in multi-year arcs. Periodize effort, keep it fun, and get social or coaching support when motivation dips.   How to connect with the guest   Website: https://timelinesciences.com   Want to be a guest on Healthy Mind, Healthy Life?   DM on PM - Send me a message on PodMatch DM Me Here: https://www.podmatch.com/hostdetailpreview/avik   Disclaimer   This video is for educational and informational purposes only. The views expressed are the personal opinions of the guest and do not reflect the views of the host or Healthy Mind By Avik™️. We do not intend to harm, defame, or discredit any person, organization, brand, product, country, or profession mentioned. All third-party media used remain the property of their respective owners and are used under fair use for informational purposes. By watching, you acknowledge and accept this disclaimer. Healthy Mind By Avik™️ is a global platform redefining mental health as a necessity, not a luxury. Born during the pandemic, it's become a sanctuary for healing, growth, and mindful living. Hosted by Avik Chakraborty—storyteller, survivor, wellness advocate—this channel shares powerful podcasts and soul-nurturing conversations on: Mental Health & Emotional Well-being Mindfulness & Spiritual Growth Holistic Healing & Conscious Living Trauma Recovery & Self-Empowerment With over 4,400+ episodes and 168.4K+ global listeners, join us as we unite voices, break stigma, and build a world where every story matters. Subscribe and be part of this healing journey. Contact   Brand: Healthy Mind By Avik™Email: join@healthymindbyavik.com | podcast@healthymindbyavik.comWebsite: www.healthymindbyavik.comBased in: India & USA Open to collaborations, guest appearances, coaching, and strategic partnerships. Let's connect to create a ripple effect of positivity. CHECK PODCAST SHOWS & BE A GUEST:   Listen our 17 Podcast Shows Here: https://www.podbean.com/podcast-network/healthymindbyavik Be a guest on our other shows: https://www.healthymindbyavik.com/beaguest Video Testimonial: https://www.healthymindbyavik.com/testimonials Join Our Guest & Listener Community: https://nas.io/healthymind Subscribe To Newsletter: https://healthymindbyavik.substack.com/ OUR SERVICES   Business Podcast Management - https://ourofferings.healthymindbyavik.com/corporatepodcasting/ Individual Podcast Management - https://ourofferings.healthymindbyavik.com/Podcasting/ Share Your Story With World - https://ourofferings.healthymindbyavik.com/shareyourstory STAY TUNED AND FOLLOW US!   Medium - https://medium.com/@contentbyavik YouTube - https://www.youtube.com/@healthymindbyavik Instagram - https://www.instagram.com/healthyminds.pod/ Facebook - https://www.facebook.com/podcast.healthymind Linkedin Page - https://www.linkedin.com/company/healthymindbyavik LinkedIn - https://www.linkedin.com/in/avikchakrabortypodcaster/ Twitter - https://twitter.com/podhealthclub Pinterest - https://www.pinterest.com/Avikpodhealth/ SHARE YOUR REVIEW   Share your Google Review - https://www.podpage.com/bizblend/reviews/new/ Share a video Testimonial and it will be displayed on our website - https://famewall.healthymindbyavik.com/   Because every story matters and yours could be the one that lights the way!   #podmatch #healthymind #healthymindbyavik #wellness #HealthyMindByAvik #MentalHealthAwareness#comedypodcast #truecrimepodcast #historypodcast #startupspodcast #podcasthost #podcasttips #podcaststudio #podcastseries #podcastformentalhealth #podcastforentrepreneurs #podcastformoms #femalepodcasters #podcastcommunity #podcastgoals #podcastrecommendations #bestpodcast #podcastlovers #podcastersofinstagram #newpodcastalert #podcast #podcasting #podcastlife #podcasts #spotifypodcast #applepodcasts #podbean #podcastcommunity #podcastgoals #bestpodcast #podcastlovers #podcasthost #podcastseries #podcastforspeakers#StorytellingAsMedicine #PodcastLife #PersonalDevelopment #ConsciousLiving #GrowthMindset #MindfulnessMatters #VoicesOfUnity #InspirationDaily #podcast #podcasting #podcaster #podcastlife #podcastlove #podcastshow #podcastcommunity #newpodcast #podcastaddict #podcasthost #pocdastepisode #podcastinglife #podrecommendation #wellnesspodcast #healthpodcast #mentalhealthpodcast #wellbeing #selfcare #mentalhealth #mindfulness #healthandwellness #wellnessjourney #mentalhealthmatters #mentalhealthawareness #healthandwellnesspodcast #fyp #foryou #foryoupage #viral #trending #tiktok #tiktokviral #explore #trendingvideo #youtube #motivation #inspiration #positivity #mindset #selflove #success

Al son de Miles Davis, Javier Sampedro y Pere Estupinyà analizan la actualidad científica de la semana, desde las enseñanzas que nos deja la carrera científica de Jane Goodall a la advertencia de los ingenieros de Microsoft por la posible fabricación de armas biológicas con Inteligencia Artificial.

Una entrevista con Zeina Alhmoud para hablar sobre gramática cognitiva y uso de imágenes en la clase de español. The post Gramática con imágenes: LdeLengua 168 first appeared on LdeLengua.

Episode 131 – Part 3 of Season 2: Forever Chemicals Detox 101 Your DNA is not a life sentence. While genetics play a role in health, research shows that everyday exposures from your home and environment generally matter far more in determining long-term outcomes. In this episode of Practical Nontoxic Living™, Sophia Ruan Gushée introduces how household toxic exposures, specifically PFAS (forever chemicals) exposure, can influence cancer. You'll hear why most cancers and many chronic conditions are driven not by genes, but by environmental and lifestyle factors. Most importantly, you'll learn simple, practical steps you can take at home to reduce exposures and protect your family's health. RESOURCES For access to the detailed slide presentation and workbook mentioned in this episode, check out the Forever Chemicals Detox Crash Course. Explore the 40-Day Home Detox for a step-by-step plan to transform your home into a wellness ally. Detox your pots and pans with help from "Safest Non-Toxic Cookware: Top PFAS-Free Pots and Pans for Healthy Cooking"

¿Cuáles fueron los orígenes del monacato cristiano y sus motivaciones? Para entender la historia de la Iglesia, es fundamental comprender esta forma de vida tan influyente tanto en Oriente como en Occidente.SÍGUENOSSitio web: http://biteproject.com​​​x: https://twitter.com/biteproject​​​Podcast: https://anchor.fm/biteprojectTikTok: https://www.tiktok.com/@biteprojectInstagram: https://www.instagram.com/biteproject/Facebook: https://www.facebook.com/biteproject/​​​Créditos:Producido por: Giovanny Gómez Pérez y Pilar PrietoMúsica: Envato ElementsGeneración de voces: Daniel ÁngelEdición de sonido y música: Jhon Montaña

Sarah Richardson talks about her new exciting research on insulin producing beta-cells that are single cells or small clusters rather than in islets.  These extra-islet beta-cells make up most of the insulin producing capacity of the pancreas in young children and are particularly susceptible to immune attack in Type 1 diabetes.  This important research explains why the loss of insulin producing cells in Type 1 diabetes is more severe in young children and informs future work on treating and preventing Type 1 diabetes.Send us a text

Join Cameron English and Dr. Chuck Dinerstein on Episode 135 of the Science Dispatch podcast as they discuss: Genes and heart health: Is there a specific gene that increases heart-disease risk in black people? More importantly, does that knowledge improve our ability to treat individual patients? Fragmented health care: Why is medicine so compartmentalized—divided into isolated specialties that treat specific body organs and ailments—and does this fragmentation hinder patient care?

BBC Mundo habló con miembros de la Flotilla Global Sumud (GSF), mientras se acercan a una zona donde otras flotillas han sido interceptadas.

Diógenes da Cunha Lima (1937) professor, poeta e biógrafo. Celebra alguns detalhes da vida quase nunca percebidos. Escute o episódio da semana, na companhia da obra Footloose and Fancy Free de Rael Jones. Obrigado

Dr. Tomi Pastinen, director of Genomic Answers for Kids, led the first clinical study of five-base long read sequencing, recently published in the Journal of the American Medical Association Pediatrics. This new method shows doctors more of the genome and can diagnose rare diseases with a single test.

Why should we challenge the assumption that the Greek magical text, the Hygromanteia, is really the source of the Key of Solomon? Why is Frankenstein's Monster a better way to look at the collection of ‘Solomonic' manuscripts? What is a ‘Solomonic network' with ‘genes', ‘nodes' and ‘clusters'? Dr. Gal Sofer - scholar, medical doctor and translator - discusses his first book, Solomonic Magic: Methodology, Texts, and Histories (Brill 2025), answers your Patreon supporter questions and more!⇓ ⇓ ⇓►⚡Dr. Sofer's ‘Solomonic Magic' tome - https://brill.com/display/title/64906►✅Dr. Sofer's Academia page: - https://bgu.academia.edu/GalSofer ►▶️Dr. Sofer Lecture: Wisdom and Command | The Magical Seals of Solomon - https://youtu.be/iu5lPccZLyw?si=XdTw7iZwA2bUV9UP ►▶️Dr. Sofer Lecture: From Seals to Pentacles| The Magical Seals of Solomon - https://youtu.be/zgjeysr5OK0?si=SLSiY04YxDt5U2mm ►Email Dr. Sofer - gal.sofer1@gmail.com ✦

Eddie Patterson talks about their show Dad Genes in Melbourne Fringe.

Send us a textGenetic & environmental factors that affect brain health, including why people age faster in outer space. (Note: technical difficulties affected the audio quality of this recording somewhat)Episode Summary: Dr. Jacob Raber explains how apolipoproteins, particularly ApoE, influence brain health and disease risk; their role in cholesterol metabolism, Alzheimer's disease, and responses to environmental stressors like radiation and viral infections; interplay between genetics, diet, and lifestyle factors, highlighting how these affect cognitive function and resilience to stress; research into space radiation, the gut-brain axis, and potential interventions for neurodegenerative diseases.About the guest: Jacob Raber, PhD, is a neuroscientist at Oregon Health & Science University (OHSU) in Portland, where he leads a lab studying genetic and environmental influences on brain health, particularly using mouse models with human genes.Discussion Points:Apolipoproteins (ApoE2, E3, E4) are proteins involved in cholesterol and lipid metabolism in the brain, with ApoE4 increasing risks for Alzheimer's and cardiovascular disease.ApoE4 carriers may face higher risks for cognitive decline but could have advantages in specific contexts, like fertility or certain infections.Environmental stressors, such as space radiation and viral infections like West Nile, can exacerbate oxidative stress, impacting brain health.The gut microbiome influences brain function indirectly via the gut-liver-brain axis, with ongoing studies exploring its role in Alzheimer's and traumatic brain injury.Lifestyle factors like diet, exercise, and sleep are critical for brain health, potentially mitigating genetic risks like ApoE4.Statins, commonly used for cholesterol management, may impair learning in healthy animals, suggesting context-dependent effects.Research into space radiation reveals potential therapeutic applications, such as using heavy ion radiation for cancer treatment.Genetic variations, including ethnicity and sex, influence ApoE-related disease risks, with women and certain populations showing higher Alzheimer's susceptibility.Chronic low-level stressors, like air pollution, may pose greater risks to brain health than acute exposures due to insufficient activation of protective mechanisms.Related content:M&M 165: PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet*Not medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

En entrevista con Pamela Cerdeira, para MVS Noticias, Carolina Gil, conductora del noticiero en MVS Puebla, explicó cómo es que con inteligencia artificial un estudiante de prepa hace fotos eróticas de sus compañeras y crea un catálogo.See omnystudio.com/listener for privacy information.

Espacio patrocinado por Lidl Porque comprar en Lidl ¡merece la pena! www.lidl.es Descripción del episodio: Esta noche en El Centinela del Misterio con Manuel Carballal y Luz Oliva, vamos a conocer los orígenes del Satanismo, y les contaremos las creencias vinculadas al satanismo a partir de una revisión histórica y antropológica, de un culto tan temido y extraño, como desconocido. Dirección y Presentación. Carlos Bustos Realización. David Castillo Responsable de Producción. Helen Bustos MetRadioTV ¿Quieres hacer crecer tu negocio? Anúnciate en El Centinela del Misterio. Infórmate mandando un WHATSAPP al 📲 +34 636 601 031 Apóyanos y hazte Mecenas para escuchar gratis toda la programación de El Centinela del Misterio. https://go.ivoox.com/sq/300018 ¿Te apetece ser miembro de “El Club de El Centinela”? Podrás asistir a las grabaciones de nuestros programas en los Estudios Manu Carballal, además de obtener descuentos en nuestros artículos de merchandising, y poder conseguir beneficios y descuentos en la totalidad de actividades y eventos que realicemos dentro de la gran familia de “El Centinela”(viajes, teatros, jornadas del misterio, etc.) Puedes informarte por WhatsApp en el 📲 +34 636 60 10 31 Sigue nuestras actividades en https://instagram.com/carlosbustos_centinela?igshid=MzMyNGUyNmU2YQ%3D%3D&utm_source=qr ©️ ®️El Centinela del Misterio 25/09/2025 Queda expresamente prohibida la reproducción total o parcial de este programa/podcast, por cualquier procedimiento, plataforma de difusión, medio de comunicación, así como el tratamiento informático, el alquiler o cualquier otra forma de cesión sin la autorización previa y por escrito de los titulares del copyright y propietarios de los derechos de El Centinela del Misterio. Los colaboradores, asistentes y personas que usan la palabra en el espacio El Centinela del Misterio, se hacen responsables unilateralmente de las opiniones vertidas en el mencionado espacio, y ceden los derechos de su actuación, emisión y redifusión, únicamente a El Centinela del Misterio y a la empresa propietaria de sus derechos. Los usuarios que decidan ejercer su derecho de opinión en el foro de este podcasts, son los únicos responsables de las opiniones vertidas y escritas. Aun así El Centinela del Misterio se reserva el derecho de admisión de dichos usuarios en este foro. También se reserva el derecho a eliminar comentarios que vulneren las normas de dicho foro, bloquear perfiles, además de reservarse el derecho a tomar acciones legales en caso de que ciertos comentarios sean constitutivos de delito según el Código Penal Español. Así mismo, si algún usuario del foro se siente ofendido por otros miembros de dicho foro, será de su única responsabilidad realizar los pantallazos de dicho comentario ofensivo, de poner la correspondiente demanda judicial, para que en caso de ser admitida a trámite, sea un juez quien solicite a la plataforma IVOOX todos los datos con el fin de poder identificar al emisor de esos supuestos comentarios escritos susceptibles de ser delictivos. El Centinela del Misterio y la empresa propietaria de sus derechos, quedan totalmente al margen y sin responsabilidad alguna, de los comentarios y de los ataques personales y de posibles suplantaciones de personalidad que puedan darse entre los usuarios de nuestro foro en IVOOX. ©️ ®️El Centinela del Misterio 25/09/2025 Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Espacio patrocinado por Lidl Porque comprar en Lidl ¡merece la pena! www.lidl.es Descripción del episodio: Esta noche en El Centinela del Misterio con Manuel Carballal y Luz Oliva, vamos a conocer los orígenes del Satanismo, y les contaremos las creencias vinculadas al satanismo a partir de una revisión histórica y antropológica, de un culto tan temido y extraño, como desconocido. Dirección y Presentación. Carlos Bustos Realización. David Castillo Responsable de Producción. Helen Bustos MetRadioTV ¿Quieres hacer crecer tu negocio? Anúnciate en El Centinela del Misterio. Infórmate mandando un WHATSAPP al 📲 +34 636 601 031 Apóyanos y hazte Mecenas para escuchar gratis toda la programación de El Centinela del Misterio. https://go.ivoox.com/sq/300018 ¿Te apetece ser miembro de “El Club de El Centinela”? Podrás asistir a las grabaciones de nuestros programas en los Estudios Manu Carballal, además de obtener descuentos en nuestros artículos de merchandising, y poder conseguir beneficios y descuentos en la totalidad de actividades y eventos que realicemos dentro de la gran familia de “El Centinela”(viajes, teatros, jornadas del misterio, etc.) Puedes informarte por WhatsApp en el 📲 +34 636 60 10 31 Sigue nuestras actividades en https://instagram.com/carlosbustos_centinela?igshid=MzMyNGUyNmU2YQ%3D%3D&utm_source=qr ©️ ®️El Centinela del Misterio 25/09/2025 Queda expresamente prohibida la reproducción total o parcial de este programa/podcast, por cualquier procedimiento, plataforma de difusión, medio de comunicación, así como el tratamiento informático, el alquiler o cualquier otra forma de cesión sin la autorización previa y por escrito de los titulares del copyright y propietarios de los derechos de El Centinela del Misterio. Los colaboradores, asistentes y personas que usan la palabra en el espacio El Centinela del Misterio, se hacen responsables unilateralmente de las opiniones vertidas en el mencionado espacio, y ceden los derechos de su actuación, emisión y redifusión, únicamente a El Centinela del Misterio y a la empresa propietaria de sus derechos. Los usuarios que decidan ejercer su derecho de opinión en el foro de este podcasts, son los únicos responsables de las opiniones vertidas y escritas. Aun así El Centinela del Misterio se reserva el derecho de admisión de dichos usuarios en este foro. También se reserva el derecho a eliminar comentarios que vulneren las normas de dicho foro, bloquear perfiles, además de reservarse el derecho a tomar acciones legales en caso de que ciertos comentarios sean constitutivos de delito según el Código Penal Español. Así mismo, si algún usuario del foro se siente ofendido por otros miembros de dicho foro, será de su única responsabilidad realizar los pantallazos de dicho comentario ofensivo, de poner la correspondiente demanda judicial, para que en caso de ser admitida a trámite, sea un juez quien solicite a la plataforma IVOOX todos los datos con el fin de poder identificar al emisor de esos supuestos comentarios escritos susceptibles de ser delictivos. El Centinela del Misterio y la empresa propietaria de sus derechos, quedan totalmente al margen y sin responsabilidad alguna, de los comentarios y de los ataques personales y de posibles suplantaciones de personalidad que puedan darse entre los usuarios de nuestro foro en IVOOX. ©️ ®️El Centinela del Misterio 25/09/2025

In this episode, we step inside the NHS to explore how the Generation Study is brought to life - from posters in waiting rooms to midwife training. We follow the journey of parents joining the study at the very start of their baby's life, and hear from those making it happen on the ground.  Our guests reflect on the teamwork between families and hospitals, the importance of informed consent, and the powerful insights this study could unlock for the future of care and research.  Our host Jenna Cusworth-Bolger, Senior Service Designer at Genomics England, is joined by:  Tracie Miles, Associate Director of Nursing and Midwifery at the South West Genomic Medicine Service Alliance, and Co-Investigator for the Generation Study at St Michael's Hospital in Bristol Rachel Peck, parent participant in the Generation Study and mum to Amber If you enjoyed today's conversation, please like and share wherever you listen to your podcasts.  For more on the Generation Study, explore:  Podcast: How has design research shaped the Generation Study  Podcast: What can we learn from the Generation Study  Podcast: What do parents want to know about the Generation Study  Blog: Genomics 101 - What is the Generation Study  Generation Study official website   “I think from a parent's point of view I guess that's the hardest thing to consent for, in terms of you having to make a decision on behalf of your unborn child. But I think why we thought that was worthwhile was that could potentially benefit Amber personally herself, or if not, there's a potential it could benefit other children.” You can download the transcript, or read it below. Jenna: Hi, and welcome to Behind the Genes.   Rachel: I think if whole genome sequencing can help families get answers earlier, then from a parent perspective I think anything that reduces a long and potentially stressful journey to a diagnosis is really valuable. If a disease is picked up earlier and treatment can start sooner, then that could make a real difference to a child or even Amber's health and development. Jenna: My name is Jenna Cusworth-Bolger and today I have the great pleasure to be your host. I'm a senior service designer at Genomics England specifically working with the hospitals involved in delivering the Generation Study. In March 2023 we started with our very first hospital, St. Michael's in Bristol. I am today joined by Tracie Miles who I had the utter pleasure of working closely with when they were setting up. And we also have Rachel Peck, one of the mums who joined the study in Bristol. Regular listeners to this podcast may already be familiar with the Generation Study but for those who are not, the Generation Study is running in England and aims to sequence the genomes of 100,000 newborn babies from a cord blood sample taken at birth. The families consented to take part will have their babies screened for over 200 rare genetic conditions most of which are not normally tested for at birth. We expect only 1% of these babies to receive a condition suspected result, but for those 1,000 families that result could be utterly life changing as it could mean early treatment or support for that condition. Would you like to introduce yourselves and tell us what it means to you to have been that first hospital open in this landmark study. Tracie, I'll come to you first.  Tracie: Hi Jenna, lovely to be with you all this morning. And for those who are listening it is early in the morning, we get up early in the morning because we never know when these babies are going to be born on the Generation Study and we have to be ready for them. So, my name is Tracie, I am the Co-Investigator with the wonderful Andrew Mumford, and we work together with a huge team bringing this study to life in Bristol. I am also the Associate Director of Nursing and Midwifery at the South West Genomic Medicine Service Alliance. Jenna: Thanks Tracie. We're also joined today by Rachel. Would you like to introduce yourself and your baby, and tell me when you found out about the Generation Study?  Rachel: Hi, thank you for inviting me. My name's Rachel, I'm based in Bristol. My baby is Amber; she was born four months ago in St. Michael's hospital in Bristol. I first heard about the Generation Study when I was going to one of my antenatal appointments and saw some of the posters in the waiting room. Amber is napping at the moment, so hopefully she'll stay asleep for long enough for the recording. Jenna: Well done, that's the perfect mum skill to get a baby to nap whilst you're busy doing something online. So, Rachel, you said you heard about the study from a poster. When you first saw that poster, what were your initial thoughts? Rachel: I thought it was really interesting, I haven't come across anything like that before and I thought the ability to screen my unborn baby at the time's whole genome sounded really appealing.  Jenna: Fantastic. So, what happened after the poster?  Rachel: If I remember correctly, I scanned the QR code on the poster which took me to the website. I filled out a few simple questions online and then I was contacted by one of the research team where I arranged a formal consent conversation. That was done by Zoom I think in the evening because I've already got a toddler at home so post bedtime works best for me. So, we had about a forty-minute conversation on the phone where I could ask all the questions that I needed to ask and if I was happy which I was. I then gave my consent and then I believe my maternity records were kind of highlighted to say that I signed up for the Generation Study and that when my baby was born then a sample was going to be taken, and I would be given the results in due course. Jenna: And did all that go smoothly, that you're aware of? Rachel: Yeah, as far as I'm aware. It was genuinely really simple to do. After that initial consultation where I signed the consent form there wasn't any follow-up appointments so the next thing I knew, I think it was just chance, but one of the research nurses actually came down to see me on the day which was really nice. Just to say, ‘Oh, just to let you know that the team are aware.' And then, other than that, the next thing I knew was getting the results through by post. Jenna: Sure. So, behind the scenes your baby's blood was collected from the umbilical cord, that would have been registered, packaged, sent off and went on a whole journey for you to ultimately get your result. It all sounds very simple, but I think we're going to dig into a lot of the mechanisms that kind of went behind the scenes to make something that seems simple come to life. Tracie, we met in the summer of 2023 I believe. I came to St. Michaels with a suitcase full of our materials which we had started to bring to life, including that poster. We've sat together and we were trying to figure out exactly how this was going to come to life in our very first hospital and how, what Rachel described, was actually going to become real. Tracie, can you tell me what you remember about those conversations and the thinking that you did as a team ahead of getting that green light to go ahead and start recruiting?  Tracie: Listeners, just to let you know that Rachel hasn't been primed to say that it was a seamless journey from delivery to getting results. I'm delighted to hear that it was. And I think the reason that we've achieved that in Bristol and across England now with the other teams that Jenna and the team have helped roll out, is teamwork. And part of our team is our mum, in this case Rachel. If you hear me or Jenna describing our mums as "Mia", that's the name, the significant name or the identifier we give for our participant. So, yeah, Jenna, I think the thing was it was about those first conversations. It was about teamwork and who shall we involve? We involved everybody didn't we, Jenna? So, I know that the team, by the time they came to us they'd already been planning for two years. So, in fact what came to us in Bristol was a wealth of work and information, and two years of behind the scenes of the team working. We involved every midwife. Now a midwife is a cover all term.  We involve community midwives, research midwives, antenatal midwives, post-natal midwives. They all do different things for the mum pathway. Not forgetting dad as well, he is involved in all of this and Rachel I'm sure will testify later to the fact that when she was offered the consent, her partner was offered to come along too. UHBW, that's United Hospital Bristol and Western, that our maternity hospital as part of, have got a fantastic R&D department and they were on straightaway with the rule book checking that we knew what we were doing. So, for those of you that aren't in the medical world, that's making sure we've got the right governance, that we're doing things by the rule book. Andrew went out and spoke to lots of different clinicians that would be involved in the pathway after the results were back, for those babies where we found a condition suspected. So, essentially Jenna, I think the list that was fairly long, grew longer and longer. Jenna: I think that was something that I was really struck by when I came back and visited you repeatedly after that. You were particularly good at getting some of those staff members that you might not even think about involved in the study, like the receptionist on your sonography department who you had recruited to make sure that they gave out the leaflet and the participant information sheet to all the mums coming in for their twenty-week scans etc. All that thinking was really valuable and something that I've passed on and taken out on my trips to other hospitals along the way. We heard from Rachel that she heard about this study from the poster. Now that you've been going for just over a year, what are all the different ways that people hear about the study, is it just the poster? Tracie: No, it's not just the poster. So, essentially when we first opened, we had lots of material. We had banners, we had posters. A short leaflet that you might often pick up at the GP, a little one that you can unfold into three pieces, and then a bigger patient information leaflet which actually described the whole study and also signposted the mums and dads to go and have a look on the website to hear more about it. What we did was we literally walked the mum's journey as she came into the hospital through antenatal and placed those posters and leaflets in the places where we knew she would see them. Now we had to be very careful about that as well because we couldn't just distribute them everywhere, we wanted to make sure that mum was getting sight of them, or mum and dad if they were coming together, at a place where their pregnancy was in hopefully, a safe position. So, that's around about 20 weeks onwards.   We didn't want to be giving that information out in the early days of pregnancy when actually mum and dad are getting flooded with lots of information, but we wanted them to feel secure in their pregnancy and for us to feel clinically secure. That worked really well and really effectively, but there's nothing like people pairing. So, in fact getting our ultra sonographers. So, for those of you that have been through pregnancy will remember at around about twenty weeks you have a scan, it's often called a dating scan or an anomaly scan, and we would get our receptionist to physically hand out a leaflet then. What we have evolved over the last year working with the team from Genomics England to make sure that we keep the wording right so that we can share with all the other sites across England, because it's good to have consistency. And also, as this evolves if this becomes standard of care, if this proves that actually this is useful for future-proofing for all of us in the public, if this study becomes something in real clinical terms, we've actually started sending out what we call, a signposting email. So, this is an email that goes to all of our prospective parents at 20 weeks plus, once we've checked that the pregnancy is safe and healthy. That has absolutely paid dividend and actually plays into the NHS future promise of analogue to digital to using those quick smart ways of working to reach our families. So, that has created a huge influx of recruits for us, Jenna.  Jenna: That's really interesting. We've sort of observed that same sort of thing. As we go through the hospitals now there's kind of three main ways that people are finding out the study. We call it like the passive way. So, that's what Rachel did which is the posters, the banners, but that doesn't work for everyone. In hospitals poster blindness is real. And also, you're coming for your twenty-week scan, you've got other things on your mind. You're not really looking around wanting to pick up leaflets and things and obviously we've also got to think about our non-English speakers. Or even an English speaker who sees the poster, but their literacy isn't very high, or their health literacy isn't very high. So, reading a message that says something about genomics and testing, it can be quite overwhelming for people and not something that they would respond to.  So, then we're signposting as our other kind of keyway and that's trying to get exactly what Tracie described, all the different staff involved. Who could be physically putting this leaflet in somebody's hand? Who could be mentioning it albeit briefly, just, you know, this is something you might like to consider. Rachel, I want to ask you what Tracie was describing there about the message kind of being better to be given later in pregnancy or after that 20-week scan point, because of all that information overload you get earlier in your pregnancy. Does that resonate with you?  Rachel: Yeah, I think that sounds about right. For lots of people when there's so much uncertainty in early pregnancy and I think some people are quite almost superstitious and don't want to sign up for things that potentially might not happen. So, I think from a personal perspective and from other friends who haven't been quite as fortunate, I think actually waiting until a little bit later when you've got a little bit more headspace and mental capacity for that sounds about right. I think there's too many things early on. It sounds like you're aiming at the right spot. Jenna: Absolutely. I think one of the other interesting aspects of all of this is the fact that Amber's cord blood was taken on the day that Amber was born, and I'm interested to understand a little bit about how that baton was passed from the moment that you consented, Rachel, to make sure that that sample was taken. I know it sounds like Rachel; you were in hospital at a point that the staff were there so they actually popped down to your bedside to see you but that doesn't always happen. Our teams don't work 24/7 and babies do get born at 2:00 a.m. over a bank holiday weekend. But Tracie, how do you make sure that that kind of message is passed through at St. Michaels, and what's worked well and what have the challenges been?  Tracie: So, a bit like how did we get the message through, is there one way? And the answer is no. There are posters, there are emails, etc. What we do do is first and foremost we encourage our mum, like Rachel here, and the dad, it might be two mums coming in together, to advocate for themselves. To say, ‘I'm on the Generation Study.' We don't expect that to be the only signal however because if a mum is coming in in full labour having done that a couple of times myself, I might forget. Now Genomics England have made some great bag tags, some stickers, all sorts of different visual identifiers that some hospitals around England are using, some aren't. We in fact actually don't get our mums to carry them, that may change. There are lots of different ways of doing it and every hospital maternity unit will find their fit. So, visual clues that mum and dad, or mum and mum, advocating for themselves as they come in, but also making sure that we have spoken with the delivery suite midwives and the theatre midwives.   Because in our hospital, which it seems to be the same sort of ratio around the country, sometimes up to about 40% of deliveries are done in theatre. So, we need to make sure we talk to our theatre staff and the people there as much as our central delivery or labour ward, for listeners who aren't familiar with the terms. So, we make sure that we went and walked the floor in the delivery labour ward and theatre on a regular basis. So, the task for us was to make sure that our midwives, all 200 of them know that if a mum is in the Generation Study and coming in for delivery, that they know that she's on the study. So, ways we do that is research midwives are an absolute ally, they do walk the floor. They do pop down to delivery suite and they do alert the team that there is a potential that a mum might be coming in that week with a planned Caesarean section, that's one easy. That actually can be an email. But we still do that by word of mouth, or they have a big board up in the delivery suite, which I gather is quite often the way across a lot of the country. Also, really, really key and this once again fits with our NHS plans, analogue to digital. The majority of our sites now are taking on electronic records. So, we put a key flag on the electronic record to say that this mum is on a research study. Staff are used to that because it's not the only research study that is happening. Now it doesn't have to just be an electronic note, it can be done on the retro paper notes as well. So, for those of you that have got paper notes or if we've got mums who are holding paper notes, fear not, there is an area on the notes where we can put that too. So, it's basically anywhere where we know the delivery midwife has sight of the babies' notes we will put a sticker, we will say something. So, it's one size doesn't fit all. Jenna: Yeah, what you've described there is just so lovely and so true about it's got to be belt and braces. The research team, the study team and the hospital might be a small number of people working Monday to Friday. Your people you completely rely on are those huge numbers of delivery midwives that need to have that message transmitted to them potentially over a 20 week timespan from the time the consent has happened to that day that that baby is born. So, what was really key as my role as service designer was going to the sites. I'm still doing this to this day, onboarding new sites all the time. We go and we speak to the sites, help them envisage how they might deliver this, how it's actually going to work. What's the nitty-gritty of all that mechanism that's going to happen but making sure that what they really understand is, what's the outcome? What do we want to happen? We want as many babies as possible to have those cord bloods taken and not missed. How you actually send that message whether it's through a paper note, a sticker on a paper note, giving a pack to the family to bring in so they've got something physical to hand over to their delivery midwife as a physical memento. Magnets that are put on the handover boards, or any or all of these things, in lots of ways the hospitals that have still got paper notes actually find it easier because that can staple a bag with the bottle that we use for our cord blood samples and this mum is part of the Generation Study to the front of the notes. It's more obvious than it would be as a digital flag. Tracie: I totally agree with that, it's all about that visual cue that we were talking about earlier. We actually fund a midwifery support worker, her name's Lauren. Hello Lauren, if you're listening. And what Lauren does is actually she makes sure that in all the rooms where women deliver that there are little set bags with all the equipment needed to take that cord blood. She also came up with a brilliant idea and again, a visual clue and Genomics England help us to design it, a poster. We would put on the outside of the door of mum and dad when they said they were on the study. So, if you've got a changeover of midwives then those midwives know that they're going into a room to support and deliver a mum that's got a baby on the study. Jenna: And I think that's something that's really key is what you said there about Lauren and her bright idea to create that poster and things like that, and that's been really key to how we've worked from Genomics England as a kind of service design kind of wrapper if you like around all of these hospitals. I have taken on the role of chief pollinator, so I've flown from hospital to hospital taking all the best ideas. So, Lauren's idea of the poster, I came along and I took a photograph of that poster. That poster is in a slide and that slide gets shown when I go and do onboarding and training sessions with future hospitals. Bristol were really key because as our first site and as the first early days check in we did, the photographs I took at your hospital at Birmingham Women's and at the Rosie in Cambridge which were the first three hospitals, you still to this day make up a large percentage of what we show because you were the first to have all those great ideas and we share those out. But we don't go round all the other hospitals, and we have found new ideas all the time and they are put together in our service design manual which is all available for all the sites. Something that St. Michael's can refer back to to see what new things they could be thinking about. But basically, raising up the best and allowing hospitals to borrow from each other. Before we just move on from how it all works, I just want to ask Rachel, did you notice any of that or were you very busy having a baby? And did you remember to kind of advocate to yourself and mention the study? Rachel: I did remember to advocate for myself, also it was one of the jobs that I allocated to my husband as well as a, well, if I forget which is likely, can you make sure that you mention to them. I had a caesarean section. For other people who have had caesarean sections, there's quite a lot of waiting round time. So, when we were in the theatre getting ready, having a chat with the anaesthetist it was a nice opportunity to be able to take my mind off the impending surgical procedure and just mention about the Generation Study. But incidentally, they knew about it anyway. I think I remember seeing some kind of sticker or maybe the blood tubes or something on my theatre records. But see them taking the sample, I wasn't aware, I had other things on my mind at that point. Jenna: Absolutely. You were cuddling Amber for the first time probably. One of the things that you touched on Tracie, was you had to go round all of your delivery suite midwives and make sure they all knew how much blood to take, what tube to put it in. The fact that they had to invert it 10 times, put it in a particular fridge so that you knew where to find it. All of those are really important training messages that you had to pass on. But for you to be able to pass them on, we had to train you in the first place. So, my memory was that we came down to you one cold December day and spent a whole day with you down at St. Michaels trying our best to train you as seamlessly as we could. My memory of that day is it wasn't terribly slick because it was our first and we're always learning. I'd like to think we've got it a lot more slick now, but what do you remember about that day? And just in general kind of learning what you needed to do on the study and what kind of worked well for you, and what worked less well? Tracie: I do remember that day, it was very cold. I think what's changed Jenna is on that December day the whole team felt that they were having to take on the whole of the journey. They now as the work has developed, realise and learn the part of the journey that they need to be involved in and don't have to be concerned about the rest of the journey. Jenna: I learnt an awful lot and I think it's really true that it's really important that people who are taking the samples, they just need to know their role. But they do need to know a little bit about what the study is, why it's worthwhile, why this mum has signed up and what value it's going to bring to that family. I think the other thing that we learnt when we came to your training as well was in the same way that we went a bit too deep for some people in their role, we didn't go deep enough for your team that were actually going to be doing these consent conversations. At that, at end of that training day, you still felt trepidatious about doing those conversations and so we really took that on board and then developed our informed choice cards which are like scenario cards that allow teams to kind of practice, rehearse and think through how they're going to answer those common questions. And we've taken those into a session that allows people who are just doing the consent conversation to go even deeper, so we do that online in a webinar now which we run monthly and that allows any new members of staff to go that little bit deeper in terms of what is this consent conversation? What is it that I need to get people to understand and be fully informed about before they come into this study? A key objective of the Generation Study which after all is a research study, is to understand if the NHS and families would benefit if screening for conditions via whole genome sequencing was something that became part of NHS standard care. Rachel, can I ask you as a mum, is that something that you've reflected on at all and how would you feel about it?  Rachel: Yeah, I've thought about quite a bit. I think if whole genome sequencing can help families get answers earlier then from a parent perspective, I think anything that reduces a long and potentially stressful journey to a diagnosis is really valuable. If a disease is picked up earlier and treatment can start sooner, then that could make a real difference to a child or even Amber's health and development. So, I think that would be potentially very advantageous. I guess in a resource limited NHS that we have, there are, you know, clear challenges in rolling out whole genome sequencing for everyone. But I'm guessing that the Generation Study will provide the evidence to help understand if this is feasible or worthwhile. And clearly the Generation Study needs to show that the screening of these 200 or so conditions is as good as the existing screening that already exists. From a parent perspective, if it's shown to be equally as good at doing that, plus all these other disorders then it seems like a win-win.  I think for me the main advantage and the main reason why I was keen to enter for Amber was if she were at risk of getting one of these rare disorders then there's an advantage to picking that up earlier for her. Because I'm aware that lots of people if they have a rare disorder, it can take a long time to get to that diagnosis and that can be really stressful for you as the parent but also for the child. Anything I think to minimise their suffering is worthwhile. So, it sounds fantastic, if it works. Jenna: Absolutely and I think that's what's really nice about being involved in something like this is that the study itself is set out to find out those things. It's not set out to find out how we could do whole genome sequencing in the NHS, it's whether we should. As part of the study, you also consented to have Amber's data go through into the National Genomic Research Library which leads us to one of the secondary objectives of the Generation Study which is to understand the implications of keeping a baby's genomic data over their childhood, or even over their lifetime. Amber will be contacted when she is 16 by Genomics England to find out whether she herself is happy for her data to be kept. But keeping that data for that length of time offers up opportunities for further screening for other conditions later in Amber's life. Or using that data with your consent of course, to do further research into genes and health. And so over the next few years you may be contacted by Genomics England to invite you to take part in future studies. And, I was just wondering about how much you have been told about the potential for that and again, how you feel about that kind of aspect of being part of this study. Rachel: Yeah, that was definitely discussed quite a lot in the consent conversation that I had with Siobhan, and we were told that Amber's data would be stored long term and that there might be future opportunities for the team to kind of get in touch or do additional testing. And I think from a parent's point of view I guess that's the hardest thing to consent for in terms of you having to make a decision on behalf of your unborn child. But I think why we thought that was worthwhile was that could potentially benefit Amber personally herself, or if not, there's a potential it could benefit other children. So, I think that whole kind of for the greater good, that kind of prevailed. And I think the other, not concern as it were, but other thing we wanted to discuss with that consent was the security of that data. And certainly, when I was discussing it with my husband that was his kind of main point to kind of clarify, if the data is being stored long term and if that was safe. And in terms of the safety, thinking about could future employers or can insurance companies, you know, get hold of that data? As a parent, the last thing you want to do is accidentally prevent your daughter from getting a job that she wants to get. But it was all explained that that wouldn't happen, but I think that was something that was us for us personally important to clarify. Jenna: I think that's really where that depth of the consent conversation is so key and why we do that sort of additional training to allow staff who may be very used to doing research and doing research consent, but never before have done a genomic consent where it's about keeping genomic data and the implications of keeping it for that really long time. What else do you remember about that consent conversation, Rachel? Is there anything else that kind of stands out that you had to sort of really dig into with Siobhan on that day?  Rachel: I'm just trying to think back because it was a little while ago. The main kind of points that I want to discuss was the security of the data and then what would happen if for whatever reason the umbilical cord blood sample wasn't taken and if that meant that we could still be part of the study or not. It was explained that yes, there is a way, they would do an initial heel prick blood sample. But that was reassuring to know that if for whatever reason if there was some kind of emergency and it didn't happen the way we wanted. So, I think that was the other kind of practical thing that was discussed.  Jenna: It sounds like Siobhan sort of had by that point all of the answers at her fingertips, but that kind of links back I guess to how important it is for all the training and all of the materials, because quite a lot of the answers to those questions are in the participant information sheet. Quite a few of them are covered in the participant video which is a sort of a four-minute-long video, it's meant to make the understanding a little bit more accessible. But it's not relying on one route of information, it's the conversation and that face to face you have with someone. It's the written information and it's those videos and other materials. So, we need to go as far as we can to kind of get the word out. One of the limitations that we had, certainly back in the day when we just had St. Michael's and a couple of other hospitals on board was that trying to get the word out about the study widely was also going to disappoint quite a lot of people who weren't able to take part because their hospital wasn't in it. We've talked a lot about this consent conversation, and I think something that's really important, underpinning for the whole study is the ethics that's been involved and all the work that's been done around that area. As the study is free and optional and taking part involves a commitment from families to have babies' data held for at least 16 years, the consent conversation and getting that right is so vital. We touched upon this in a previous episode with my colleague Mathilde Leblond where we talked about all the design research that our team did in the build up to launching this study, so that we could really deeply understand what families wanted and needed as part of their experience. So, Tracie, we've heard from Rachel the things that she was concerned around, but what were your reflections as a team in St. Michaels around the ethical aspects of the study? And what has been particularly tough about that in relation to you guys in Bristol? Tracie: I would say informed consent is something that we all take as healthcare professionals, and we all hold dearly the governance. So, I was mentioning earlier that actually consent may not be a one-off situation. So, for example, Rachel had forty minutes with Siobhan. That was the conversation that she had where Rachel felt that she was enabled and informed enough to take consent, and Siobhan listening to her having that conversation with Rachel felt that that was appropriate at the time. So, consent was achieved between the two of them. Now, that wasn't the only part of Rachel's consent is Rachel was telling us there's the patient information leaflet that she read, so that's also part of the informed consent. And we have to be sure that our mums and the other parent of the baby have read that information. And one of the things that I was very worried especially about at the beginning was it's a superb information leaflet, it's quite long, it needs to be. It signposts the parents of the unborn baby to a website which is fantastic. Do they all look at it? Not always. Would I? Probably not. So, there's no criticism of the parents here. So, one of the things that I was really concerned about from the genomics perspective of this and the data protection because this is not a one-off, this is a longitudinal study. Amber when she's 16 years old will decide whether or not she wants to continue, so it's not a one-off moment that her lovely mum and dad have consented her for. There's a lot that's been consented for. All great and all appropriate and all future-proofing for future Ambers. But my concern was actually, are we getting that information across to all the mums and dads as they sign up? So, it was really important that when we were training our midwives and our genomic practitioners, those that were consenting, to make sure that they were really cognisant of the enormity of the wealth of science we were signing our parents and their babies' futures up to. Jenna: Indeed, and very well said and I think you touched on something that is really close to our hearts as well that we've thought a lot about but still continue to do work to get right, which is the patient information leaflet if you have the health literacy and written language literacy to be able to sit and read a 16-page document, great, but not everybody does. As I've gone place to place and hospital to hospital, I'm always struck by the different communities that surround different hospitals and the different challenges that they might have. So, if you compare somewhere like Royal London which is in the heart of Whitechapel, I think around 40% of their birthing parents there are first generation Bengali women who have little to no English. Also, whose health literacy is quite low as well. So, engaging them takes a very different approach to an approach you might take elsewhere. So, it's definitely not a one size fits all. Tracie, how have you adapted some of your approaches to your local communities in Bristol? Tracie: So, we have a fairly diverse population, not as diverse as the Whitechapel example that you gave, but in fact we were aware, a bit like the team in London that we have a population of Somali potential birthing parents. What we've done is we've worked with community leaders and elders from the Somali population to develop a day, or it might be a couple of mornings, for us to talk about and workshop to explain about the study. So, we have all of the information. We have the translations that have been done by Genomics England. And hat we are doing is we are working with the community elders for them to tell us the right fit. Should it be a whole day? Probably not. Should it be a coffee morning or a tea morning? Probably. Should it be where we get a guest speaker in? That was their idea. What is the key condition suspected, one of those 200 conditions that the study is looking at that is prevalent in that community? Let's ask the community elders what they think, and we'll do what we're told. So, it's been fabulous actually doing that. Jenna: It's really, really great to hear about that. I think we've got little pockets of work like that popping up all over the country now which is really exciting to start seeing. I think at first, we were very much about getting the study up running and out there. And now we're starting to make sure we get that reach and we get that equity, and the opportunity for all pregnant people to decide whether this is right or wrong for their family. It's about informed choice and you can't make an informed choice whether that's an informed yes or an informed no if you don't have the information. We are proud that we go further than most research studies in terms of our accessibility, in terms of translations and we know that not English speaking is not the only barrier to access, there's lots of cultural barriers as well. But with the translated materials we support 10 languages as far as our professionally translated participant information leaflet. I was also really pleased when I found out at first that our website team had built the website in such a way that it worked not only with screen readers. So, somebody with a visual impairment could ‘read', in inverted commas, the website but that also it translates via Google into the 160 languages that Google support, which we know Google translations aren't perfect but they're better than nothing. And going back to what Tracie sort of said, the website doesn't have to do everything, it's about a conversation at the end of the day. It's a consent conversation that can be supported by a professional interpreter but it's about getting that initial message out there so they even get as far as having that conversation with an interpreter. We heard from Rachel around her reflections for the future, Tracie, about the study potentially becoming NHS standard care and about that potential of us having Amber and 99,999 other babies' data in the National Genomic Research Library and the potential that gives us for further research. Or for potentially re-screening those children as they grow up. When you look to the future and think about the Generation Study and what it might pave the way for, what are your hopes or perhaps fears? Tracie: So, my belief working in the genomics field is genomics is everybody's business. So, it's the 3 of us talking today, we're all very keen about genomics but there is a fear around genomics. Actually, I feel that this landmark study is absolutely fantastic. It makes genomics everybody's business. And it actually helps the whole healthcare community looking after these parents and the unborn babies as they go through the journey learn about the positivity of genomics. I think this landmark study is an absolutely win-win. It speaks to the whole family. Jenna: Thank you, Tracie. I'm also particularly excited about what the future could hold. I think as the service designer that's been working so closely with the hospitals, I'm really excited around what we've learned through this study in terms of reaching families and getting genomic information and options out to them. As you say, it is everybody. I continue to enjoy meeting new hospitals and seeing their kind of innovative take on that and kind of pollinating that back to other trusts so that we can reach as many families as possible and get that equity of access for everybody. I'm also particularly excited that we're moving into a phase where we're going to be learning more from the parents themselves that are taking part.  So, I think we'll wrap up there. Thank you to our guests Rachel, Tracie for joining me today as we discuss the rollout and impact of the Generation Study at St. Michael's Hospital in Bristol. If you'd like to hear more about this, please subscribe to Behind the Genes on your favourite podcast app. Thank you for listening. I've been your host Jenna Cusworth-Bolger. This podcast was edited by Bill Griffin at Ventoux Digital and produced by Deanna Barac.

El tifón Ragasa tocó tierra en China con vientos sostenidos de 144 km/h, después de pasar cerca de Hong Kong y Filipinas.

How do we understand the world? Over the last couple of decades, new sources of data have given us great insights into our deep past — and our deep present.Welcome to Episode 117 of Everything is Everything, a weekly podcast hosted by Amit Varma and Ajay Shah.In this episode, Amit and Ajay discuss what our genetic data tells us about our prehistory — and how phone battery life can reveal character!Also discussed: lipstick, underwear, diapers and parking lots. :)TABLE OF CONTENTS: 00:00 Packaging00:13 Intro: The Importance of Measurement05:00 Chapter 1: The History38:57 Chapter 2: Getting Into the Details50:44 Chapter 3: Ajay's Journey With the Data59:51 Chapter 4: The Russia-Ukraine WarFor full show notes, please click here!

Dr. Aideen McInerney-Leo explores hereditary melanoma (CDKN2A), diagnostic disclosure in Turner syndrome, mainstreaming genomics, gene therapy, and the expanding role of genetic counsellors in research and patient care. Through clinical stories, family perspectives and practical takeaways on testing and screening, this episode highlights how research and clear communication improve outcomes — with a personal note on the therapeutic craft of bead-making.

Las calles de más de 80 ciudades de Italia se llenaron de pancartas y banderas palestinas etse lunes para exigir el fin de la ofensiva israelí en Gaza.

¿Quien es Al Simmons? ¿Por qué hizo un pacto con Malebolgia? Descubrir con nosotros las historias misteriosas relacionadas con el cómic Spawn. Desde historias de ángeles, asesinos en serie, experimentos del gobierno, curaciones milagrosas hasta personajes como Cogliostro. ¿Quieres anunciarte en este podcast? Hazlo con advoices.com/podcast/ivoox/158506

We often blame our DNA for autoimmune disease and chronic illness. But what if the real inheritance isn't genetic at all? What if it's the food on the table, the unspoken stress, the toxins in our homes, and the patterns no one questions? In this episode of Medical Disruptors, Dr. E talks with Divya Gupta, a former Silicon Valley consultant who left the career everyone admired to reclaim her health. From gallbladder surgery at 20 to a Hashimoto's diagnosis at 25, Divya reveals how years of dismissed symptoms taught her the most dangerous form of gaslighting is when you start doubting yourself. She shares why gallbladders aren't disposable, how the thyroid and liver are deeply connected, and why bile may be the most overlooked part of your health. Together we explore the invisible inheritance families pass down—habits, foods, and beliefs that shape health outcomes for generations. This conversation challenges the myth that your destiny is written in your DNA. It's about reclaiming your voice, trusting your body, and breaking cycles that no longer serve you. Looking to become a book a session with Dr. E? Book here: drefratlamandre.com/consult Get Dr. E's guide on how to build a case for yourself here: https://freechapter.lpages.co/how-to-build-a-case-for-yourself/ Check us out on social media: drefratlamandre.com/instagram drefratlamandre.com/facebook drefratlamandre.com/tiktok Divya's website: https://divyagupta.net Divya's IG: https://www.instagram.com/_divgupta Divya's FB: https://www.facebook.com/profile.php?id=100064007228684 Learn more about your ad choices. Visit megaphone.fm/adchoices

Hannah Robinson was the first adult in the UK to be given the new immunotherapy drug Teplizumab, which aims to slow down the development of type 1 diabetes. Hannah had multiple pancreatic autoantibodies and hence is on the path to developing Type 1 diabetes (Series 4 Episode 3). Her consultant, Nick Thomas, arranged 14 consecutive daily hospital visits for her to receive the drug through a drip. Send us a text

In this episode, Dr. Scott A. Johnson discusses the rising challenges of fertility and infertility with Dr. Aumatma Simmons, a leading expert in holistic fertility care. They explore the statistics surrounding infertility, the genetic and environmental factors influencing fertility, and the importance of nutrition and lifestyle modifications. Dr. Simmons emphasizes the role of methylation and the impact of toxins on reproductive health, while providing practical advice for couples trying to conceive. The conversation highlights the need for early intervention and personalized approaches to fertility care.Connect with Dr. Scott A.Johnsonauthorscott.comFacebook Instagram YouTube Links to purchase booksConnect with Dr. SimmonsConnectwith Dr. Aumatma on InstagramCheck out Dr. Aumatma on the TEDx Stage!HolisticFertilityInstitute.com| madrefertility.comTakeawaysInfertility affects 10-15% of couples worldwide.Genetic mutations can significantly influence fertilityoutcomes.Methylation issues are increasingly recognized in fertilitydiscussions.Diet and lifestyle are crucial for preconception health.Environmental toxins, especially plastics, impact fertility.Sleep quality is foundational for reproductive health.Early intervention can prevent long-term fertility issues.Holistic approaches can address root causes of infertility.Personalized nutrition is key to optimizing fertility.Healthy babies start with healthy parents.Chapters00:00 Introduction to FertilityChallenges03:28 Understanding InfertilityStatistics05:54 The Role of Genetics inFertility08:34 Methylation and Its Impacton Conception11:13 Nutritional Foundations forFertility13:43 Essential Nutrients forPreconception and Pregnancy16:26 Diet and LifestyleModifications for Improved Fertility22:11 The Importance of Sleep inFertility26:45 Understanding Fertility as aMultifaceted Issue31:51 The Impact of EnvironmentalToxins on Fertility39:35 Guidance for Couples FacingFertility Challenges43:05 Short Outro.m4v

In this episode of Healthy Waves, host Avik Chakraborty sits down with three powerful voices—Julie Alsaker, Trey Tijerina, and Thomas R. Wilson—to unpack the deeper dimensions of resilience. We often hear that grit and mindset define strength, but what if resilience is also written in our genes, our beliefs, and our stories? This conversation bridges science, spirituality, and storytelling, showing how biology influences stress, how inner scripts shape transformation, and how community and belonging reinforce mental strength. About the Guests   Julie Alsaker is the founder of Lux Bioanalytics and a holistic genetic specialist with over 25 years in alternative health. She pioneers ways to integrate genetics, blood markers, and holistic care for true healing. Trey Tijerina is a visionary entrepreneur exploring psychology, spirituality, imagination, and the human impact of AI. He blends ventures and frameworks that challenge limits and open paths to transformation. Thomas R. Wilson is a writer, advocate, and community leader. Through storytelling and sensory-friendly events, he empowers neurodiverse and marginalized communities, proving resilience is born from courage and belonging. Key Takeaways   Genetics play a role in how stress is processed, and understanding your DNA can guide resilience strategies. Mental scripts and inner narratives influence how physiology responds and how transformation unfolds. Resilience is not fixed—it is a choice shaped daily by the state of consciousness we live from. Storytelling offers connection, representation, and advocacy, especially for neurodiverse and marginalized voices. Community resilience depends on inclusion, accessibility, and the power of healthy boundaries. Resilience is both prevention and adaptation—some learn through experience, others through wisdom, but all are shaped by how they relate to challenges. Self-love and compassionate boundaries strengthen personal and community resilience. Connect with the Guests   Julie Alsaker: Facebook – https://www.facebook.com/julie.alsaker Trey Tijerina: Social Media – @whypaytrey Thomas R. Wilson: https://www.rhcreativeadvocacyandstorytelling.net/  LinkedIn | Email: NDTTRPG@gmail.com   Want to be a guest on Healthy Mind, Healthy Life? DM on PM - Send me a message on PodMatch DM Me Here: https://www.podmatch.com/hostdetailpreview/avik Disclaimer: This video is for educational and informational purposes only. The views expressed are the personal opinions of the guest and do not reflect the views of the host or Healthy Mind By Avik™️. We do not intend to harm, defame, or discredit any person, organization, brand, product, country, or profession mentioned. All third-party media used remain the property of their respective owners and are used under fair use for informational purposes. By watching, you acknowledge and accept this disclaimer. Healthy Mind By Avik™️ is a global platform redefining mental health as a necessity, not a luxury. Born during the pandemic, it's become a sanctuary for healing, growth, and mindful living. Hosted by Avik Chakraborty—storyteller, survivor, wellness advocate—this channel shares powerful podcasts and soul-nurturing conversations on: • Mental Health & Emotional Well-being• Mindfulness & Spiritual Growth• Holistic Healing & Conscious Living• Trauma Recovery & Self-Empowerment With over 4,400+ episodes and 168.4K+ global listeners, join us as we unite voices, break stigma, and build a world where every story matters.

Allergist Tina Sindher acknowledges that allergies may be affecting more people worldwide, influenced by a combination of factors such as environmental changes, modern lifestyles, urbanization, and evolving dietary habits. Prevention is playing catch-up, and promising new strategies include earlier food introduction than was popular only a few years ago. On the treatment front, hopes are rising for immunotherapies and a new prescription medicine, omalizumab, that addresses multiple allergens at once. While no single approach helps all, these strategies could allow millions worldwide to better manage their allergies, Sindher tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast. Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Sayantani (Tina) SindherConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Tina Sindher, a professor of medicine and allergy at Stanford University.(00:03:16) Inside the Immune ResponseWhy our immune systems trigger allergic reactions.(00:04:57) Genes vs. EnvironmentWhether genetics or environment drive allergy risks.(00:08:05) The Microbiome FactorThe role of the microbiome and early exposures in prevention.(00:09:17) A Global Allergy SurgeHow global allergy trends reveal rising health challenges.(00:11:56) Potent Food TriggersWhy some foods cause stronger and faster reactions.(00:13:49) Emerging RisksWhether Alpha-Gal signals new emerging allergy risks.(00:15:47) Multi-Food AllergiesHow multi-food allergies complicate diagnosis and treatment.(00:19:02) Preventing Allergies EarlyWhy early food introduction may help prevent allergies.(00:20:54) Skin's Role in AllergiesThe importance of infant skin health in allergy development.(00:23:39) Testing LimitationsThe limits of current testing methods to truly diagnose allergies.(00:25:13) Standard Testing ProcedureThe current methodologies deployed when testing for allergies.(00:27:28) New TherapiesHow new therapies like OIT and Xolair are reshaping treatment.(00:31:50) The Future of AllergiesThe potential of combined therapies to aid in allergy treatment.(00:34:33) Managing Seasonal AllergiesHow to manage seasonal allergies effectively at home.(00:37:08) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

Education, Science - Genome BC

Clara Ramas analiza los efectos que tiene el hecho de ver un genocidio en directo y actualizado constantemente. La analista de Hora 25 reflexiona sobre las consecuencias sociales y políticas de la tecnología, algo que estamos viendo claramente en Gaza.

Our strategy gurus never shy away from controversy. In this episode, Mark and Lorraine dive into 2025's biggest advertising controversy – the Sydney Sweeney American Eagle Jeans/Genes campaign! See how the positioning duo impartially shares their thoughts on the campaign and why the stock soared, the jeans flew off the shelf, and how American Eagle may once again be relevant to a new generation.Join Mark and Lorraine for 30-ish as they discuss all things marketing, advertising, and of course … positioning!

EXETER UFO FESTIVAL: INHERTING A FATHER'S UFO BLUEPRINT? Nat Sticco- discussing her and her husband Genes work into Soviet era reverse engineering programs of UFOs. A Blueprint. Cold War era. The fall of the USSR. A Fathers Duty to Protect State secrets. #ufo #Disclosure #TotalDisclosureBecome a supporter of this podcast: https://www.spreaker.com/podcast/total-disclosure-ufos-coverups-conspiracy--5975113/support.Featuring Steven Bassett of PRG www.paradigmresearchgroup.org Featuring Nat and Gene Sticco www.Engineeringinfinitybook.com

In this episode, we review the high-yield topic of⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Embryogenesis Genes⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Embryology section.Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets

U.S. housing regulator Bill Pulte began the campaign to remove Federal Reserve Governor Lisa Cook from her post. He explains his allegations against Lisa Cook and her colleagues at the central bank. Hundreds of employees at GE Aerospace facilities in Ohio are entering their eighth day on strike. Their representative, United Auto Workers President Shawn Fain, discusses the deal he rejected, the demands on the table, and the future of American auto manufacturing. Plus, American Eagle reported positive results from its controversial ad campaign with Sydney Sweeney, the NYC mayoral race is back in the headlines, President Trump is attempting to save his tariffs in the courts, and the White House has invited tech CEOs to the building's brand new patio.  Shawn Fain  19:42William J. Pulte 35:09 Shawn Fain, @ShawnFainUAWWilliam J. Pulte, @pulteEamon Javers, @eamonjaversBecky Quick, @BeckyQuickJoe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkinKlaire Odumody, @klairemarie

441-M-286-Id - 1635 - Las imágenes de galaxias tempranas tomadas por el telescopio Webb están proporcionando nuevos conocimientos sobre el universo primitivo. Y después, los faros de Aída. Universo de Misterios tiene reservado el derecho de admisión y publicación de comentarios. Generalmente, los comentarios anónimos no serán publicados. Si hace comentarios con afirmaciones dudosas, arguméntelas aportando enlaces a fuentes fiables (este muro NO es una red social). En caso de no respaldar su comentario como se indica en la caja de descripción del episodio, su comentario podrá ser no publicado. Contacto con Universo de Misterios: universodemisteriospodcast@gmail.com La imagen de la miniatura que ilustra este episodio ha sido creada con la ayuda de una Inteligencia Artificial. Puedes hacerte Fan de Universo de Misterios y apoyarlo económicamente obteniendo acceso a todos los episodios cerrados, sin publicidad, desde 1,99 €. Aunque a algunas personas, a veces, puede proporcionar una falsa sensación de alivio, la ignorancia nunca es deseable. Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Jerry Gore has always lived life on the edge; he had tackled some of the highest, and most inhospitable mountain climbs in the world before he was diagnosed with Type 1 diabetes aged 40.  His Type 1 diabetes has not held him back and he has learnt how to live well with his Type 1 diabetes when climbing at extreme altitude and bitter cold.  He helps people living with Type 1 diabetes throughout the world, especially in S E Asia as co-founder of Action4Diabetes (A4D). Rob Andrews is a national expert helping people with Type 1 diabetes to adapt their diabetes care so they can do any extreme activity including mountaineering, long distance swimming, and endurance cycling.Send us a text

The nation is on the doorstep of Canaan. In our Parsha, the people are instructed in how they must treat the Canaanite inhabitants of the land. It's not pleasant. The people are told that they must engage in total war against these nations. How do we understand the requirement to be so violent and aggressive […]

The nation is on the doorstep of Canaan. In our Parsha, the people are instructed in how they must treat the Canaanite inhabitants of the land. It's not pleasant. The people are told that they must engage in total war against these nations. How do we understand the requirement to be so violent and aggressive towards the Canaanite nations? What about the Canaanites who opt to join the nation? What is their status? In this podcast, we first explore the general notion of how to understand the Torah's instructions regarding the Canaanite policy, and then we explore a very interesting thread about the power of behavior and how it can get embedded in the spiritual DNA that we transmit to our descendants.– – – – – – – – – – – – – – – – – – – – – –DONATE: Please consider supporting the podcasts by making a donation to help fund our Jewish outreach and educational efforts at https://www.torchweb.org/support.php. Thank you!– – – – – – – – – – – – – – – – – – – – – –Email me with questions, comments, and feedback: rabbiwolbe@gmail.com– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to my Newsletterrabbiwolbe.com/newsletter– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to Rabbi Yaakov Wolbe's PodcastsThe Parsha PodcastThe Jewish History PodcastThe Mitzvah Podcast This Jewish LifeThe Ethics PodcastTORAH 101 ★ Support this podcast ★

Follow The Show:PatreonDiscordYoutubeInstagramX(Twitter)Follow Cipha Sounds:InstagramX(Twitter)TikTokFollow Rosenberg:InstagramX(Twitter)TIkTokThis podcast is sponsored by Monster Energy and Monster Music. Hosted on Acast. See acast.com/privacy for more information.

My guest is Dr. Sergiu Pașca, MD, professor of psychiatry and behavioral sciences at Stanford University. We discuss the biology and genetics of autism, why autism diagnoses are increasing and recent progress in using stem cells to understand and treat profound autism and other brain disorders. Dr. Pașca explains “organoids and assembloids”—human stem cell–derived tools he pioneered to study, treat and cure complex brain diseases. We also discuss ethical and safety issues with using gene editing and stem cells in humans. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Helix: https://helixsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00) Sergiu Pașca (02:08) Autism Spectrum Disorder, Incidence, Genetics (07:16) Is Autism More Common in Males? (09:35) Sponsors: David & Helix Sleep (11:56) Eye Contact in Babies, Fever; Proposed Causes of Autism; Genes (18:48) Genetic or Idiopathic Autism Diagnoses, Timothy Syndrome (21:37) Rise in Autism Diagnoses (26:46) Cause, Correlation & Neurological Disease; Schizophrenia, Do Vaccines Cause Autism? (31:34) Global Increase in Autism; Gene Therapy, CRISPR, Follistatin (41:05) Sponsors: AG1 & BetterHelp (43:41) Stem Cells, Ethics, Yamanaka Factors, Human Stem Cell Models (52:03) Umbilical Stem Cells; Stem Cell Injections & Dangers, Autistic Kids (59:30) Organoids, Modeling Brain Development, Intrinsic Development Timer (1:12:22) Assembloids, Brain Cell Migration & Circuit Formation, Self-Organization (1:21:22) Four-Part Assembloid, Sensory Assembloid, Pain Conditions (1:25:45) Sponsor: Function (1:27:33) Future Medical Therapies, Cell Banking, Immortalize Tissues, Rejuvenate Cells (1:34:56) Assembloids & Ethics, Importance of Nomenclature, Science Collaboration & Self-Correction (1:45:38) Cell Transplantation & Ethics, Timing (1:55:05) Genetic Testing for Parents, Genetic Penetrance (2:02:36) Assembloids, Timothy Syndrome, Epilepsy, Schizophrenia, Dystonia (2:14:30) Scientific Career, Walking, Art, Medical School (2:20:44) Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Allie Beth Stuckey joins Jason to discuss the viral controversy surrounding Sydney Sweeney's American Eagle ad and the reactions it received. They also explore why conservatives on social media are celebrating attractive women on the internet. Learn more about your ad choices. Visit megaphone.fm/adchoices

About this episode:  Sickle cell disease affects an estimated 100,000 people in the United States. Recent advancements in gene therapies and medicines like hydroxyurea are diminishing extreme pain, reducing strokes, and extending survival times for those afflicted by the disease. In this episode: leading sickle cell disease expert Dr. Mark Gladwin explains how revolutionary new treatments work and discusses the challenges to access to life-saving care. Guest: Dr. Mark Gladwin is a physician-scientist and the Dean of the University of Maryland School of Medicine and Vice President for Medical Affairs at the University of Maryland, Baltimore. His research focuses include sickle cell disease and hypertension. Host: Dr. Josh Sharfstein is vice dean for public health practice and community engagement at the Johns Hopkins Bloomberg School of Public Health, a faculty member in health policy, a pediatrician, and former secretary of Maryland's Health Department. Show links and related content: New sickle cell gene therapies are a breakthrough, but solving how to pay their high prices is a struggle—CNBC Gene Therapy: What You Need to Know—Sickle Cell Disease Association of American No More Pain: Breakthrough Sickle Cell Treatment from Johns Hopkins Offers Curative Potential—Johns Hopkins School of Medicine Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌JohnsHopkinsSPH on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

In this conversation, Michael Shermer and Dr. Eric Topol discuss the realties of aging, with particular focus on the role of AI in enhancing patient care and disease prevention, the importance of lifestyle factors, and the limitations of genetic testing in predicting health outcomes. Topol also explains the dangers of ultra-processed foods, their link to inflammation, and the role of GLP-1 drugs in promoting healthier eating habits. The conversation also covers diet, particularly the differences between chicken and red meat, and the significance of sleep for overall health. Plus, consumption of microplastics, cholesterol management and statins, the critical role of social connections in maintaining mental and physical health, and the future of personalized medicine in cancer prevention. Eric Topol is a cardiologist and one of the top ten most cited researchers in medicine, known for his groundbreaking studies on AI in medicine, genomics, and digitized clinical trials. Topol is also the executive vice president and a professor of molecular medicine at Scripps Research, the largest nonprofit biomedical institute in the United States. He was named one of the Top 100 most influential people in health in 2024 by Time. His new book is Super Agers.

Topics:  In this bonus episode, Brant talks about what he's learning from the book: "The Matter With Things" by Iain McGilchrist. Including: - Exploring the complexity and intelligence of living cells. - Challenging purely mechanical views of biology. - Why relationships and context are paramount.   And most importantly…   The many spiritual parallels that can be derived from the book and how who we are becoming matters way more than our past.     Quotes: “Life requires cognition at all levels. Our cells think!” “Genes do nothing on their own; life is far more than DNA.” “Flatworms can regrow their brains and still remember.” “Healing is God's work; medicine cooperates with it.” . . . Holy Ghost Mama Pre-Order! Want more of the Oddcast? Check out our website! Watch our YouTube videos here. Connect with us on Facebook! For Christian banking you can trust, click here!

Demi in Martha's Vineyard (on Appleton Estate); Shannon Shape is more than just a dirty old man; Mad Black people just got re-married; And Just Like That (Finally) Cancelled; Mad Spoilers for The Gilded Age; Beyoncé joins the jeans/genes controversy. Learn more about your ad choices. Visit podcastchoices.com/adchoices

My guest is Dr. Nirao Shah, MD, PhD, a professor of psychiatry, behavioral sciences and neurobiology at Stanford University School of Medicine. We discuss how the brains of males and females differ and how those differences arise from different genes and hormones during fetal development, in childhood and adulthood. We discuss what drives male- versus female-specific behaviors and how hormonal fluctuations across the lifespan, including puberty, the menstrual cycle, menopause and aging – affect behavior, cognition and health. Additionally, we discuss how biology relates to gender identity and the impact of hormone therapies on brain circuits that regulate mating, parenting and social bonding. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui: https://mauinuivenison.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Nirao Shah 00:02:11 Mice, Humans & Brain, Biological Conservation 00:05:25 Hormones, Nature vs Nurture 00:07:13 Biological Sex Differences, Chromosomes & SRY Gene, Hormones 00:16:01 Sponsors: Maui Nui & Eight Sleep 00:19:09 Androgen Mutations, Feminization & Masculinization 00:22:04 SRY Gene; Animals & Sexual Trans-Differentiation 00:27:49 Hormones & Biological Brain Differentiation 00:31:22 Congenital Adrenal Hyperplasia, Androstenedione; Stress & Pregnancy 00:35:56 Genes, Brain Differentiation & Sexual Identity; Congenital Adrenal Hyperplasia 00:43:37 Testosterone, Estrogen & Brain Circuits 00:47:27 Sponsors: AG1 & LMNT 00:50:36 Intersex Individuals, Castration 00:52:23 Female Sexual Behavior, Brain, Testosterone & Pheromones 00:57:58 Identify as Heterosexual or Homosexual, Difference in Hormone Levels? 01:00:42 Gender, Sexual Orientation & Hormones; Hormone Replacement Therapy 01:10:21 Aromatization; Steroid Hormones & Gene Expression 01:15:00 Kids & Changing Gender Identity 01:19:05 Sexual Behavior, Refractory Period & Male Brain, Tacr1 Cells 01:21:31 Sponsor: Function 01:23:19 Hypothalamus, Dopamine, Prolactin, Cabergoline, Libido, Dopamine 01:27:05 Brain Circuits, Aggression & Sexual Behavior 01:32:40 Refractory Period; Age, Testosterone & Libido 01:36:07 Tacr1 Cells in Females, Periaqueductal Gray & Innate Behaviors 01:40:00 Parenting Behaviors & Brain Circuits; Pet Dogs 01:43:12 Oxytocin, Pair Bonding, Vasopressin; Biological Redundancy 01:47:22 Libido, Melanocortin, Tacr1 Neurons; GLP-1 Agonists, Clinical Trials; Kisspeptin 01:56:43 Female Brain Changes, Menstrual Cycle, Pregnancy, Menopause; Estrogen; Men & Hormone Fluctuation? 02:04:10 Life Experience Male vs Female, Sex Recognition, Behaviors & Context 02:16:05 Pain Management; Endocrine Disrupters, Gender Identity 02:21:03 Future Projects 02:24:29 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices