Podcasts about Membrane

 Industrial Water Week is here—and Day 1 is Pretreatment Monday. This special episode sets the tone for the week with specific ways to celebrate as a team, sharpen field practices, and share what you do with the people who matter most. Celebrate with purpose Host Trace Blackmore outlines simple, high-signal actions: take a field photo with your pretreatment gear, tag it #IWW25, #IndustrialWaterWeek, and #ScalingUPH2O, and post it today! Inside your company chat (Slack, group text, etc.), mark each day's theme so momentum builds across Boiler Tuesday, Cooling Wednesday, Wastewater Thursday, and Careers Friday.  Foundations to futures  This year's theme—Water's Industrial Journey: From Foundations to Futures—is a prompt to audit your own growth. Trace describes the shift from “knowing” to “understanding” when fundamentals interlock, and challenges veterans and newcomers to keep learning in an ever-changing field.  You'll hear a Pretreatment Monday greeting from Tessa Nge of HOH Water Technology, plus the debut of a new Detective H2O case, The Case of the Singing Canary. Follow along on LinkedIn and guess the guest voices—Trace reveals them on Friday.   Whether you bake a cake for your crew or host a brief daily stand-up, make the week visible. The work you do improves reliability, energy use, and water stewardship—worth celebrating and worth doing well.  Want to learn more about Industrial Water Week? Visit the free Resources dropdown at www.ScalingUpH2O.com to explore all things Pretreatment, Boilers, Cooling, Wastewater, and Careers in water.    Stay engaged, keep learning, and continue scaling up your knowledge!    Timestamps    01:53 - Trace Blackmore welcome everyone to the Industrial Water Week: Scaling UP H2O as official place to celebrate  05:55 – Field Photo Prompt: Post Pretreatment Equipment Shots; tag #IWW25, #IndustrialWaterWeek, and #ScalingUPH2O  19:29 – Guest Greeting: Tessa Nge (HOH Water Technology)   25:33 – Detective H2O: The Case of the Singing Canary    Connect with Tessa Nge  Phone: +1 224-545-7870  Email: tnge@hohwatertechnology.com  LinkedIn: https://www.linkedin.com/in/tessaskilton/      Links Mentioned  AWT (Association of Water Technologies)  Scaling UP! H2O Academy video courses  Submit a Show Idea  The Rising Tide Mastermind  Industrial Water Week  Water Cake Recipe   Chloride Elution Study Procedure and Data Interpretation  Industrial Water Week Resources Page Ep 392 Breaking Barriers: How Diversity and Confidence Drive Growth in Water Treatment  

This is part one of a two-part recapBelow Deck Med returns with a crew of dummies ready to wreck the new boat. Sandy starts on a positive note, but when the episode ends with floating wave runners and an abused light fixture, we know it's going to hell quickly. Yay! To watch this recap on video, listen to our bonus episodes, and participate in live episode threads, go to Patreon.com/watchwhatcrappens. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This is part 2 of a 2-part recap Below Deck Med returns with a crew of dummies ready to wreck the new boat. Sandy starts on a positive note, but when the episode ends with floating wave runners and an abused light fixture, we know it's going to hell quickly. Yay! To watch this recap on video, listen to our bonus episodes, and participate in live episode threads, go to Patreon.com/watchwhatcrappens. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this week's episode of The Energy Code, Dr. Mike Belkowski sits down with Victor Sagalovsky, co-founder of Litewater Scientific, to explore one of the most cutting-edge frontiers in mitochondrial optimization: deuterium depleted water (DDW). Victor, a longtime water researcher and pioneer in bringing ultra-low deuterium water to the world, shares how this overlooked isotope may hold the key to boosting energy production, extending healthspan, and even influencing genetic expression.   Expect a mix of quantum biology, practical lifestyle strategies, and a deep dive into the physics of water as Dr. Mike and Victor decode how lowering deuterium levels impacts mitochondrial health and human longevity. Key Topics Covered Victor's Origin Story – How a lifelong fascination with water led him to co-found Litewater Scientific and make deuterium depleted water accessible . What is Deuterium? – Breaking down the isotopes of hydrogen and why deuterium disrupts mitochondrial ATP synthase, causing “stutters” in energy production. The Mitochondrial Connection – How excess deuterium damages membranes, reduces proton motive force, and accelerates aging. Deuterium & Disease – The striking links between high deuterium levels, cancer risk, and neurodegeneration. Thresholds for Health – Why 120 ppm is considered the metabolic “line in the sand,” and how most modern water supplies far exceed this. How DDW is Made – The massive proprietary columns and energy-intensive process behind creating 10 ppm and 5 ppm light water. Psychological & Cognitive Benefits – Correlations between lower deuterium levels and improved mood, optimism, and confidence. Lifestyle Strategies – Beyond DDW: fasting, ketogenic diets, hydrogen inhalation, and limiting overconsumption of food and water. Practical Outcomes – How listeners can begin to measure, lower, and optimize their own deuterium levels for energy and longevity. Key Quotes   Victor Sagalovsky: “Every eight seconds, an ATP synthase stutters because of deuterium—it's the kiss and the elbow at the same time.” “Our physiology is designed for about 120 ppm of deuterium, but most people are sitting at 150 or higher—that's the metabolic danger zone.” “When you deplete deuterium, your body thanks you. You feel lighter, both metaphorically and literally.”   Dr. Mike Belkowski: “When I first tried Litewater, I felt an immediate pull—like my cells wanted more. It was magnetizing.” “The implications for cognition, mood, and even neurodegeneration are massive when you consider how mitochondrial dense the brain is.” Episode Timeline   00:00 – Introduction & the promise of radical life extension   01:30 – Dr. Mike introduces Victor and Litewater Scientific   04:00 – Victor's background as a water researcher and discovery of DDW   07:00 – Why deuterium is the hidden disruptor in energy production   12:00 – How ATP synthase “stutters” under deuterium load   18:00 – Membrane damage, proton leakage, and mitochondrial shutdown   24:00 – Cognitive, emotional, and energetic effects of lowering deuterium   32:00 – The massive engineering challenge of producing ultra-low deuterium water   39:00 – Deuterium and cancer risk: research, case studies, and suppression   46:00 – The “line in the sand” for ppm and metabolic safety   55:00 – Lifestyle strategies: fasting, keto, hydrogen inhalation, and exercise   01:00:00 – Testing, tracking, and maintaining optimal deuterium levels   01:03:00 – Closing thoughts on energy, freedom, and future of water Resources & References Litewater Scientific Book: Deuterium Depletion: A New Strategy in Cancer Therapy - Dr. Gabor Somlyai Dr. Zoltán Nagy – Research on ATP synthase stutter and deuterium's role Deuterium Depletion Resource Hub

Could this new material finally change Reverse Osmosis for the better? Let's dig into it! More #WaterTech insights? Get my free water investor database: https://investors.dww.show

What if the secret to making continuous bioprocessing practical, sustainable, and far simpler has been shaking - literally - just beneath our feet?For years, the industry has grappled with the complexities of continuous manufacturing, with technologies like ATF (alternating tangential flow) steadily dominating the perfusion landscape. But what if there's a game-changer right around the corner - a technology that vibrates membranes, not workflows, promising both higher performance and a greener footprint?Enter Jarno Robin, a pioneering force in membrane filtration and Pharma Business Development Director at Sani Membranes. With two decades of experience implementing ATF and championing continuous innovation in bioprocessing, Jarno isn't just speculating about change—he's building it. In this episode, host David Brühlmann gets hands-on with Jarno as they unpack Sani's patented Vibro Membrane Filtration (VMF) technology and its bold promise to transform upstream and downstream bioprocessing.Here are three reasons you can't afford to miss this conversation:Vibration Over Crossflow: Sani's VMF system shakes up conventional wisdom by using vibration to generate turbulence, achieving uniform transmembrane pressure, reducing cell damage, and enabling robust, scalable separations across applications from mAbs to cultivated meat and even challenging mRNA workflows.Seamless Tech Swap (and Sustainability): Transitioning from ATF or TFF to VMF? Jarno explains how the setup is surprisingly straightforward, requires fewer connections at scale, dramatically cuts chemical use, and can slash your environmental footprint, as membranes last years instead of months.Innovation Demands Resilience: Beyond equipment specs, Jarno pulls back the curtain on what it really takes to drive innovation in pharma: relentless belief, hours of extra work, and the patience to let good data - and internal advocates - build momentum for change.Ready to see bioprocessing through a new lens? Tune in to discover how vibrating membranes may help you simplify your CMC development pipeline, reduce waste, and position your organization for a more continuous, efficient future.Connect with Jarno Robin:LinkedIn: www.linkedin.com/in/jarno-robinWebsite: www.sanimembranes.comCurious about continuous processing challenges and breakthroughs? Don't miss these previous episodes.Episodes 39-40: Balancing Perfusion Process Development and Sustainability with Jochen SieckEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosNext step:Book a free consultation to help you get started on any questions you may have about bioprocess development: https://bruehlmann-consulting.com/call

A repair of this Tennismatic T1000 remote control was way more interesting than I expected. https://tennismatic.com/main/page_products_ball_machines_t100_series.html Forum: https://www.eevblog.com/forum/blog/eevblog-1702-a-most-interesting-repair/ 00:00 – Tennismatic 1000 Tennis ball machine remote control 00:53 – Battery snap ohms measurement 01:17 – Battery current measurement 02:29 – It's a row/column thing 02:57 – Teardown 05:20 – Membrane inspection 06:44 – Membrane keypad …

What if one of biotech's biggest production breakthroughs was hiding in plain sight? Not in a new gene or a wonder drug, but in the way we process and purify biologics.Perfusion technology, once dismissed as a pipedream in top biopharma boardrooms, is now quietly powering some of the industry's most efficient and productive manufacturing platforms. Yet, transforming perfusion from controversial buzzword to gold standard required timing, vision, and a willingness to break from tradition.In this episode, host David Brühlmann sits down with Jarno Robin, a bioprocessing pioneer whose 20+ year journey spans industry giants like Novo Nordisk, Sanofi, and Leo Pharma. Jarno has championed upstream continuous processes, including ATF and TFF, for decades, and now, as a leader at Sani Membranes, he's unleashing the next evolution: Vibro® Membrane Filtration, an innovation set to upend conventional wisdom about fouling, pressure loss, scalability, energy usage, and more.Here are three reasons you'll want to listen to Jarno's journey:Innovation Versus Industry Inertia: Behind every platform shift are years of resistance. Jarno recounts how timing, advocacy, and matching the right data with the right decision-makers finally made perfusion mainstream, even after company leaders proclaimed, “We will never ever run perfusion.”State-of-the-Art and the Next Frontier: ATF and TFF remain dominant, but their limitations, like membrane fouling, scale-up headaches, and high energy needs, are real. Jarno explains how Vibro® Membrane Filtration addresses these pain points with a radically new design, offering lower pressure loss, less fouling, higher cell densities, and surprisingly low energy consumption.Practical Wisdom for Bioprocess Developers: Should you always run a control in process development? How do you translate lab-scale wins to robust, money-earning production? Jarno shares counterintuitive advice based on decades of hands-on success and mistakes.Curious how you can optimize your process technology and sidestep costly pitfalls? Listen to this episode and discover how “timing is everything” in bioprocessing innovation and whether new filtration methods could help you leap ahead.Connect with Jarno Robin:LinkedIn: www.linkedin.com/in/jarno-robinWebsite: www.sanimembranes.comCurious about continuous processing challenges and breakthroughs? Don't miss these previous episodes.Episodes 39-40: Balancing Perfusion Process Development and Sustainability with Jochen SieckEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosNext step:Book a free consultation to help you get started on any questions you may have about bioprocess development: https://bruehlmann-consulting.com/call

Pterosaur soft tissues It's a double new paper episode this time as thanks to the magic of almost random review and publication times, Dave has two papers out on the same subject in the same month! So strap in for some absolute minutiae on pterosaur hands, feet, scales, and the oddly overlooked wing membrane that sits between their legs. Pterosaurs in general are not very common fossils and so it should be no surprise that we don't have a great many examples of their soft tissues, from skin, to beaks and claws and other bits. So, having new examples, and synthesising the limited information we have, is really important for building an understanding of these incredible animals. It's deep dive time.       A link to Dave's blogpost on the new hand and foot scale papers: https://archosaurmusings.wordpress.com/2025/06/10/new-data-on-pterosaurian-soft-tissues/   A link to a very old blogpost about pterosaur soft tissues generally: https://archosaurmusings.wordpress.com/2008/07/25/pterosaur-soft-tissues/   Iszi'a new book - featuring a pterosaur and perfect for 6-9 year olds is out on 28th August in the UK: https://amzn.eu/d/9kFiniD (message her on iszi.com if you want international posting).

Trish dives into the topic of membrane sweeps. She breaks down everything you need to know about this optional procedure to help you make informed decisions for your birth.Trish explains what a membrane sweep is (also known as a stretch and sweep), how it works, tips to make it more comfortable, and why it might be considered to encourage labor naturally. She emphasizes that membrane sweeps are entirely your choice - your body, your birth, your decision. Trish shares when a membrane sweep is most effective (hint: wait until at least 40 weeks!), the importance of slight cervical dilation for the procedure, and why dilation alone isn't the whole story when it comes to labor readiness. She also encourages combining a membrane sweep with various natural labor preparation techniques.Join the Calm Mama Membership: labornursemama.com/cmsLeave a review and include your Instagram username for a chance to win our monthly raffle!More from this episode:Join Calm Labor Confident Birth or The VBAC LabGrab the Induction Workshop: available for those preparing for an induced birth.Read the Blog: Read this Easy to Understand Guide Before Your Membrane Sweep: Everything You need To KnowHelpful Timestamps:00:54 Understanding Membrane Sweeps01:26 How Membrane Sweeps Work02:39 When to Consider a Membrane Sweep03:43 Preparing for a Membrane Sweep04:28 Making Membrane Sweeps More Comfortable06:44 Post-Sweep Expectations and Tips08:37 Final Thoughts and Recommendations09:15 Join the Community and Stay ConnectedResources: Calm Labor Confident Birth Pod

ON TODAY'S SHOW: Opener Tradie V Lady Birthday Wheel O News Snap Predictions with Georgina Walker $10,000 Pop Quiz Bruno's Online Purchase History 5 in 10 O News Joel Madden Last Calls Follow us on @kyleandjackieo for more.See omnystudio.com/listener for privacy information.

Kristen Phillips, artist, writer, fabricator, and Philosophical Research Society events manager joins us for a deep dive on PRS, synchronicity, and more. We talk the legacy of Manly P. Hall, the genius of Arthur M. Young, artist Claire Pierpoint and a wild sync, aviator-mystics, Kristen's approach to art and her ongoing work The Membrane, and more. A packed conversation on many CU-classic themes! Plus: a bonus Ben-Dave patreon discussion on Rosicrucianism, Martinism, George Hunt Williamson, and more.  Join our patreon  https://www.patreon.com/c/consensusunreality The Liminal Credential https://www.instagram.com/liminalcredential/

Get well and schedule a Zoom Call@drhughwegwerth @drhughwegwerth @drhughwegwerthIn This Episode: If you've been dealing with chronic illness, fatigue, or mystery symptoms, this episode might change everything for you. Dr. Hugh breaks down cell membrane detox in a way anyone can understand—and shows why this could be the missing piece to real healing.What You'll Learn:What a cell membrane is and why it matters for your healthWhy healing your membranes can calm inflammation and boost energyHow 30 trillion cells in your body depend on one key building blockThe special nutrient called phosphatidylcholine that helps repair broken cellsHow your mitochondria, nucleus, and other organelles rely on a strong lipid bilayerWhy antioxidants like astaxanthin and vitamin E are game changersA look inside top products Dr. Hugh uses with chronic illness clientsWhat happens when membranes can't let nutrients in or toxins outWhy energy problems often start with poor cell structureThe step-by-step protocol to restore healthy membranes and reduce inflammationKey Takeaway: If you've never focused on healing your cell membranes, you're missing a powerful key to reversing chronic inflammation, fatigue, and pain. This episode is your crash course in bringing common sense back to health—starting at the cellular level.Resources Mentioned:Phosphatidylcholine products from Quicksilver ScientificUltra Binder for detox supportVitamin C, bitters, and kidney support blendsWant More? Reach out to Dr. Hugh at his clinic for help getting started. Where there is help, there's hope.Listen now and learn how to build stronger, healthier cells—starting today.

ReferencesBiomolecules. 2024 Feb3;14(2):18Clin Transl Med. 2021 Apr; 11(4): e381.Wakeman, R. 1973. The Six Wives of King Henry VIII.https://music.youtube.com/watch?v=ApohmdSVTT8&si=iY2jCzhmMQW-qM5bEmerson, K. 1970. "The Three Fates. Emerson Lake and Palmer lp.https://music.youtube.com/watch?v=vQjvBD21peI&si=zab4qB4P_i6Jm4cI

Planet Poet-Words in Space – NEW PODCAST!  LISTEN to my WIOX show (originally aired June 3rd, 2025) featuringHudson Valley poet Lisa St. John.  Lisa reads from her book Swallowing Stones and discusses her life as a poet. Poet-At-Large Pamela Manché Pearce also appears on the show. Lisa St. John is a writer living in upstate New York. She is the author of two poetry books, Ponderings (Finishing Line Press) and Swallowing Stones (Kelsay Books). She is a Best of the Net and Pushcart Prize nominee for her poem “War is a Human Child” from The Poetry Distillery. She won first place in Anthology's 2024 Poetry Award for “Through the Membrane.” Lisa is published in journals such as 2Elizabeths, New Verse News, The Poet's Billow, The Ekphrastic Review, The Orchards Poetry Journal, Light, and Entropy Magazine. Lisa believes that art is hope and that there is beauty in possibility. She is currently working on a memoir. Find out more atlisachristinastjohn.com.  Also visit: Sharonisraelpoet.com and https://www.pamelampearce.com

This episode was recorded at the 2025 Florida Ruminant Nutrition Symposium. Microbial protein has always been Dr. Frikins' main interest. It's the most important and consistent source of protein for the cow, with a very high amino acid content. Histidine is the only exception, but bypass protein sources high in histidine complement microbial protein well. Our assessment of microbial protein is all based on prediction models. In his presentation, Dr. Firkins talked about what we can do to have consistently high microbial protein production and how to make the best use of the models. He touched on starch and fat content as two areas of focus, emphasizing a balanced diet to achieve a balanced supply of microbial protein. (5:36)Dr. Firkins notes that about 90% of the bacteria in the rumen can't be cultured, and there is great diversity in the rumen. There's a core group of bacteria that almost every cow has that are really good at their job because they've been co-selected along with the cow for fiber digestion. The panel discusses how much the microbiome changes over time, host interactions with the microbial population, and inoculation of calves at birth and weaning. (8:47)Dr. De Souza and Dr. Faciola talk about starch associative effects and their impacts on fiber digestibility, how sugars impact the rumen and butyrate production, and the importance of butyrate in de novo milk fat synthesis. Dr. Frikins hypothesizes that when sugars improve fiber digestibility, the sugar stimulates how fiber digesters do their job. Some studies have shown an increase in rumen pH when sugars are supplemented, which may be part of the mechanism of improved fiber digestibility. However, he doesn't recommend using sugars when there is a lot of starch in the diet. (13:38)Dr. Faciola and Dr. Firkins discuss some of the finer points of the dietary starch and fiber digestibility relationship. What are you replacing when you add more starch? What is the proper amount of effective fiber in higher-starch diets? On the other hand, if you decrease starch a little bit, there might be more room for fat. Well-managed cows with adequate effective fiber can probably handle more starch. Dr. Firkins underlines that starch is more digestible than fiber and thus supports microbial protein, but an optimum level is desirable, perhaps 28-20%. (20:37)The panel talks about microbial growth efficiency and the energy-spilling mechanisms some bacteria have. Some models suggest that starch-digesting bacteria have higher maintenance energy requirements. The group then pivots to methane production and available feed additives marketed to reduce methane. Dr. Firkins notes that there is quite a bit of variability in the additives. He emphasizes that if we're using these products, we need to know and measure what's in them and have them be consistent. This is challenging due not only to variability in product, but also rumen adaptation. Dr. Firkins also reminds the audience that improving the cow's efficiency in general in a variety of ways will lead to a smaller environmental footprint. This can range from improving reproductive efficiency to understanding differences in the microbiome of cows who emit more or less methane and trying to shift microbial populations to those with lower emissions. (23:12)Dr. De Souza and Dr. Firkins discuss fatty acid supplementation and fiber digestion relationships. Dr. Firkins explains that in the microbiology literature, it's common to culture bacteria in a simple or complex medium, then add yeast culture. Interestingly, the yeast culture contains a lot of palmitic acid, which has been shown to improve fiber digestibility. He suggests the cell membrane of the bacteria is very critical. When fat supplementation depresses fiber digestibility, he suspects it's disrupting the bacterial membrane. Dr. De Souza recommends 1-2% palmitic acid in the diet for optimal results. (33:58)The panel touches on the importance and relevance of in vitro fermentation work, why histidine is the limiting amino acid in microbial protein, and Dr. Firkins' passion for protozoa. (43:08)Panelists share their take-home thoughts. (53:40)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

ReferencesMinireviews 2003. Volume 278, 47p46195-46198Biochemistry. 2002 Jan29;41(4):1398-408.Biochimica et Biophysica Acta (BBA) - Biomembranes 2011. 1808, 1, January Pages 127-139Annual Review of Biophysics2010. 39(1):207-26Langmuir 2019 35.30 9944-53.Guerra, DJ. 2025. Membrane lectures: unpublished.Fagen &Becker. 1973. Steely Dan "Reelin in the Years"https://music.youtube.com/watch?v=91XTZ92zs2w&si=wOhRhM6DcdmxQb4GPage, J.1972. "Rock n Roll" from LZIVhttps://music.youtube.com/watch?v=SRQ7-eSGBWc&si=2GWqbbGlSCj7u3hNMemphis Slim . 1959. "Steppin Out" Cream 1972 Live Cream Vol II lp.https://music.youtube.com/watch?v=OWTJVNPu_r4&si=9L2OwzXOk5N57b3Y

Implementation Of A Regional Extracorporeal Membrane Oxygenation Program For Out-Of-Hospital Cardiac Arrest: Results Of The Pilot Study

ReferencesGuerra, DJ. 2025. Membrane lipids lectures.Langmuir 2019 35.30 9944-53Jones, S. 1948. "Ghost Riders in the Sky" Johnny Cashhttps://music.youtube.com/watch?v=3LtmZM0OWO8&si=iayTIDz_eqmYo9naHunter, R.1978. "Rose of Sharon."https://youtu.be/-4PAVeswqME?si=dyz3dOFh-X-dTQT2&t=1Gibson, D. 1957. "Oh, Lonesome Me".https://music.youtube.com/watch?v=dzYe6O5IJWs&si=eUItyJN9JoHtxIWnVan Zandt and Collins. 1978. "Tuesday's Gone Lynyrd Skynyrdhttps://music.youtube.com/watch?v=LJrFxnvcWhc&si=VDOw8DM4zbrSuyJj

we are all over the place in part 2 of our time with Ram Long ..enjoy

we talk with Ram Long in a 4 hour 2 part session .. we had a great time and really let loose so enjoy ...PART 2 WILL BE RELEASED NEXT WEEK ..

A new efficient way to isolate rare earths was discovered at UT. A very necessary move foward in light of our recent clash with China.  https://www.msn.com/en-us/news/technology/rare-earth-element-extraction-breakthrough-could-boost-us-position-in-critical-tech/ar-AA1E3KVU?ocid=socialshare&cvid=e78be75f2c5546729895e12909c86ca3&ei=22

Saviez-vous que le choix entre un détendeur de plongée à piston ou à membrane peut tout changer selon le type d'eau dans lequel vous plongez ? Ou qu'un détendeur surcompensé vous permet de respirer plus facilement dès les premiers mètres de descente ?Dans cet épisode, Lucie et Manuel Cabrère (Aqualung) vous plongent au cœur de la mécanique interne des détendeurs de plongée, avec un focus sur les subtilités qui font toute la différence en termes de confort respiratoire.A travers un échange limpide et pédagogique, vous découvrirez :la différence entre les détendeurs à piston et à membrane, et pourquoi la membrane est à privilégier en milieu chargé ou pollué ;le rôle crucial de la compensation, qui permet de maintenir une respiration fluide quel que soit le niveau d'air restant dans la bouteille ;la mécanique de la surcompensation, une technologie qui améliore encore le confort respiratoire en profondeur, même dès 25 mètres.A travers des analogies simples — comme celle du bouchon de baignoire — Manuel rend accessibles des concepts techniques fondamentaux pour bien choisir et bien comprendre son matériel. Vous apprendrez également pourquoi certains détendeurs disponibles à la location dans la plupart des clubs de plongée peuvent montrer leurs limites, et comment un bon choix de détendeur peut transformer votre expérience sous l'eau.Ce deuxième épisode technique poursuit notre série sur les détendeurs de plongée avec clarté et précision. Un must pour les plongeurs qui veulent comprendre, sans se noyer dans le jargon !

One of the reasons why working in water is fun is the people who work in it - dedicated, driven, modest, self-effacing, hard working, but with a lightness that comes from doing something that really matters. Craig Beckman personifies these qualities and then some, and he also happens to be working on a generational - and I really do mean that it's once in a generation if the past is anything to go by - generational shift in the design of the spiral wound membrane module. Well, we'll go into it in the episode, but think of it as the basic building block, the workhorse of water treatment, a $4.6 billion a year market growing at 11%. Craig and his team have the opportunity to make something we all rely on, whether we know it or not, fundamentally better. It's such an exciting story from inception to development to their enormous production space they just moved into. But more than anything, Craig is a wonderful person to spend time with. Please enjoy my conversation with Craig Beckman. Subscribe to The Fundamental Molecule here: https://www.burntislandventures.com/the-fundamental-molecule For the full show notes, transcript, and links to mentioned content, check out the episode page here: https://podcasts.apple.com/us/podcast/the-fundamental-molecule/id1714287205 ----------- Craig Beckman shares lessons learned from GE Water and MIOX on customer needs and small company agility here today. He describes how his current venture, Aqua Membranes, revolutionizes membrane elements by replacing inefficient mesh spacers with optimized, 3D-printed structures - an innovation that targets reduced fouling and energy use, especially in industrial reuse. Discussing focused go-to-market strategies, overcoming technical challenges, and scaling production to build confidence, Craig emphasizes membrane technology's crucial role in future water security and advises persistence for water entrepreneurs. 00:00 - Building the Future of Water Through Innovation 01:59 - Lessons from Big Company Sales and GE Water Rollups 05:10 - Why Big Companies Miss Mid-Market Water Opportunities 09:18 - Balancing Recurring Revenue with Customer Needs 13:31 - Why Traditional Membrane Spacers Fail in Water Treatment 17:24 - Redesigning Membranes for High-Reuse Industrial Wastewater 21:54 - Solving Customer Pain with Elegant Membrane Engineering 27:44 - Overcoming Doubt and Manufacturing Complexity in Water Tech 31:05 - Go-to-Market Strategy for Industrial Water Startups 35:10 - Building Case Studies to Accelerate Market Adoption 39:04 - Scaling Manufacturing to Gain Customer Trust 42:19 - The Future of Membranes in Global Water Scarcity Solutions 45:04 - The #1 Advice for Water Entrepreneurs Links: Burnt Island Ventures: https://www.burntislandventures.com/ Craig Beckman: https://www.linkedin.com/in/craig-beckman-ceo/ Aqua Membranes: https://aquamembranes.com/ SM Material Key Takeaways: "Just because everyone has wastewater doesn't mean it's a good commercial opportunity." "The membrane market is poised for growth. It's a critical need for food and water security." "Persistence is key in water entrepreneurship. Be patient. Water's impact grows over time." "In water treatment, solving problems for customers is about aligning with their needs, not just trends." "Cash flow is crucial in startups. It's a lesson learned from experience." "The speed at which opportunities are pursued is crucial. Big companies often can't get out of their own way."

Join host Dr. Joe Patterson as he chats with Dr. Geoffrey Marecek about the debate in bone grafting compared to bone transport for the treatment of bone defects. For additional educational resources visit OTA.org

In this episode, Dr. Sterling discusses cervical exams during pregnancy and labor, emphasizing patient consent and comfort. Learn about why these exams are performed, how to make them more comfortable, and get a brief introduction to membrane sweeping as a potential labor-inducing procedure.Key MomentsYour Right to ConsentPurpose of Cervical ExamsBishop Score ExplainedMaking Exams More ComfortableIntroduction to Membrane SweepingConnect With Us: Join the Sterling Parents community at sterlingparents.com Follow us on Instagram @askdrsterlingpodcast Email your questions to podcast@sterlingparents.com

The Industrial Water Solutions Conference in June is co-hosted by WateReuse and WEF. Anthony Zamora, Principal Environmental Engineer at CDM … More

  Are you ready to discover the unexpected key to prospecting success that even the most seasoned sales professionals may have overlooked? Brace yourself for a surprising revelation that will transform the way you approach sales engagements. Get ready to uncover the game-changing solution that's been right under your nose this whole time. Stay tuned for the jaw-dropping insight that will revolutionize your prospecting efforts and take your sales game to the next level. Achieve Better Prospecting Engagement If you're feeling overwhelmed by the prospecting challenges and struggling to engage potential clients, then you are not alone! The traditional sales methods just don't seem to be cutting it and it's time to shake things up. Let's explore how to achieve greater prospect engagement and success through personalized, empathetic selling. It's time to transform your sales game and make prospecting a breeze! In this episode of The Modern Selling Podcast, Mario Martinez Jr. recounts his unorthodox entry into the sales world, transitioning from a photo finisher to a highly successful salesperson. He underscores the importance of trust-building and genuine assistance in sales, rather than aggressive tactics. Throughout the conversation, key themes such as the challenges of modern prospecting, the integration of human intelligence with AI, and the impact of personalized communication on sales strategies emerge. Mario's personal journey serves as a testament to the resilience and dedication required in the sales profession, offering valuable insights for aspiring sales professionals. His practical advice and emphasis on adapting to the evolving sales landscape make this episode essential for those seeking to enhance their sales efforts. The hardest part about selling is not anything but prospecting. - Mario Martinez Jr. In this episode, you will be able to: Overcome Sales Prospecting Challenges: Learn effective strategies to conquer common obstacles and boost your prospecting success. Harness the Power of Human Assisted AI in Sales: Discover how the fusion of human touch and AI technology can supercharge your sales efforts. Elevate Your Sales Cadences with Referrals: Uncover the pivotal role referrals play in enhancing your sales process and driving better results. Master Personalization Strategies for Sales Success: Unleash the potential of personalized selling to forge stronger connections and win more deals. Leverage LinkedIn for Modern Sales Strategies: Explore the impactful role of LinkedIn in shaping contemporary sales approaches and expanding your reach. The key moments in this episode are: 00:00:00 - The Power of Sales Coaches and Managers 00:00:30 - Leveraging AI in Sales 00:00:43 - Mario's Journey into Sales 00:03:39 - Overcoming Financial Challenges 00:10:40 - Hunter's Revelation 00:11:16 - Hunter Anderson's Advice 00:14:21 - Diverse Sales Experience 00:18:12 - Modern Buyer Challenges 00:20:48 - Engaging Modern Buyers 00:25:54 - The Importance of Personalization in Sales Prospecting 00:26:34 - The Limitations of AI in Sales 00:27:58 - The Role of Personal Investment in Sales 00:29:39 - Leveraging Human-Assisted AI in Sales 00:30:16 - The Power of Referral in Sales Cadences 00:39:58 - The Art of Helping in Sales 00:40:13 - Spreading Wisdom and Knowledge 00:40:30 - Elevating Each Other 00:40:47 - Podcast Rating and Productivity Tip Timestamped summary of this episode: 00:00:00 - The Power of Sales Coaches and Managers Mario discusses the importance of sales coaches and managers who can share success stories and help their team overcome the challenges of prospecting. 00:00:30 - Leveraging AI in Sales Mario emphasizes the need to combine human intelligence with AI tools to achieve real results in sales. 00:00:43 - Mario's Journey into Sales Mario shares his inspiring journey into sales, starting from his time as a photo finisher and how he transitioned into B2B software sales. 00:03:39 - Overcoming Financial Challenges Mario recounts how he applied for numerous scholarships and worked part-time to pay for his education at UC Berkeley, showcasing his resilience and determination in the face of financial obstacles. 00:10:40 - Hunter's Revelation Mario recounts the pivotal moment when his district manager, Hunter, recognized his sales skills while working as a photo finisher, leading to a significant turning point in his career. 00:11:16 - Hunter Anderson's Advice Hunter Anderson recognized Mario Martinez Jr.'s sales potential and advised him to pursue a sales role, leading to a successful career in sales. 00:14:21 - Diverse Sales Experience Mario Martinez Jr. discusses his diverse sales experience, serving various industries and segments, managing large teams, and his journey from a sales intern to a successful sales professional. 00:18:12 - Modern Buyer Challenges Martinez highlights the challenges faced by salespeople in engaging with modern digital buyers, emphasizing the importance of omni-channel approaches and hyper-personalization in sales prospecting. 00:20:48 - Engaging Modern Buyers Martinez shares insights on the need for hyper-personalization and value-driven messaging in engaging modern buyers, emphasizing the importance of PVC sales methodology and the limitations of traditional prospecting methods. 00:25:54 - The Importance of Personalization in Sales Prospecting Mario emphasizes the importance of personalization in sales prospecting. He discusses the significance of getting a prospect to say yes and the need for human-assisted AI in the sales process. 00:26:34 - The Limitations of AI in Sales Mario talks about the limitations of AI, highlighting that AI can be two-dimensional and may not fully grasp contextual relevance. He stresses the necessity of human intelligence in sales to complement AI. 00:27:58 - The Role of Personal Investment in Sales Mario discusses the need for sales reps to invest in their own tools and technologies to enhance their effectiveness, rather than solely relying on the organization. He highlights the importance of personal initiative in sales success. 00:29:39 - Leveraging Human-Assisted AI in Sales Mario emphasizes the significance of aligning human intelligence with AI in sales. He stresses the need for real intelligence in using AI effectively to connect person-to-person, rather than solely relying on AI capabilities. 00:30:16 - The Power of Referral in Sales Cadences Mario emphasizes the importance of starting sales cadences with referrals, highlighting that 84% of buyers start their buying process with a referral. He emphasizes the need to transform LinkedIn profiles to engage buyers effectively. 00:39:58 - The Art of Helping in Sales Myra emphasizes the importance of prospecting and invites the audience to learn more. Mike emphasizes that sales is the art of helping, highlighting the need for collaboration and support in the sales world. 00:40:13 - Spreading Wisdom and Knowledge Mike encourages the audience to like, subscribe, and share the podcast to spread wisdom and knowledge in the sales world. He emphasizes the critical nature of understanding and helping each other in the industry. 00:40:30 - Elevating Each Other Mike encourages the audience to keep shining bright and have an amazing day, emphasizing the importance of lifting each other up. He highlights the need for mutual support and collaboration in the sales industry. 00:40:47 - Podcast Rating and Productivity Tip Mike asks for a 5-star rating and review for the podcast on iTunes. He also recommends downloading FlyMSG to save time and increase productivity in writing.   The resources mentioned in this episode are: Visit FlyMSG.ai to try the AI-powered sales prospecting tool for free. No credit card required. Check out Vengreso, Inc. at vengreso.com to learn more about their sales training and prospecting solutions. Connect with Mario Martinez Jr. on LinkedIn and mention that you heard him on the Membrane podcast to engage with him directly. Watch Vengreso, Inc.'s referral training video on YouTube for a comprehensive guide on how to ask for referrals in your sales process. Download FlyMSG at flymsg.io to save 20 hours or more in a month and increase your productivity with a free text expander and personal writing assistant.

This week The President of The United States of America and Tech Stuff Guy discuss Sleepy Joe Pardons, Iran, Stockmarket, St. Patricks Day, NCAA Tournament, and more. We are also joined by Don Jr for a short recap of what is going on in his life. If you enjoy the show leave a rating and review on spotify or iTunes. Join the Patreon for hours of bonus content www.Patreon.com/MPGA Learn more about your ad choices. Visit megaphone.fm/adchoices

Gm! This week we're joined by Carson Cook & James Roth from Membrane Labs to discuss the current state of crypto lending. We deep dive into the differences between crypto's 2021 cycle & today, the Terra/Luna fallout, institutional appetite for lending in crypto & much more. Enjoy! -- Follow James: https://x.com/juniorroth22 Follow Carson: https://x.com/LiquidityWizard Follow Jason: https://twitter.com/JasonYanowitz Follow Empire: https://twitter.com/theempirepod Join the Empire Telegram: https://t.me/+CaCYvTOB4Eg1OWJh Start your day with crypto news, analysis and data from Katherine Ross. Subscribe to the Empire newsletter: https://blockworks.co/newsletter/empire?utm_source=podcasts -- Use Code EMPIRE10 for 10% off tickets to Digital Asset Summit 2025: https://blockworks.co/event/digital-asset-summit-2025-new-york -- ZKsync is the pioneering zero-knowledge technology powering the next generation of builders with limitless scale. Secured by math and designed for native interoperability, ZKsync enables an elastic, ever-expanding network of customizable chains. Deeply rooted in its mission to advance personal freedom for all, the ZKsync technology makes digital self-ownership universally available. To learn more about ZKsync, visit http://www.zksync.io -- Token.com is a social-first crypto platform transforming how people discover and trade through crypto content. The revolutionary in-feed trading turns complex crypto into intuitive investments, while content creators earn from every trade and projects amplify their stories through native tokens - creating a new era of social media-powered crypto discovery. Just scroll to watch and tap to invest. Download the app! -- Get up to speed on the biggest stories in crypto each week. In five minutes. Get the Bitwise Weekly CIO Memo delivered directly to your inbox at bitwiseinvestments.com/ciomemo/empire -- WalletConnect is the onchain connectivity network . If you've connected to a Web3 app, you've seen WalletConnect. It's everywhere—an icon of trust in crypto, as recognizable as Visa at checkout. The numbers speak for themselves: Over 220 million connections and 35 million users worldwide use WalletConnect to power their Web3 experience. @WalletConnect on X and Telegram or visit https://WalletConnect.Network -- Timestamps: (00:00) Introduction  (00:40) Crypto's Leverage Unwind In 2021-22 (08:41) The Terra/Luna Fallout (14:30) Ad ZKSync (15:35) What We Learned From Last Cycle (19:11) Who Are The Big Lenders In This Cycle? (23:32) Ad ZKSync (24:37) Token Generation Events (31:02) Will Institutions Start Lending In Crypto? (35:08) Ads (Token.com. Bitwise, WalletConnect) (37:22) What Is Membrane? (48:40) Over vs Under Collateralized Lending (58:22) What Will Blow Up This Cycle? -- Disclaimer: Nothing said on Empire is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Santiago, Jason, and our guests may hold positions in the companies, funds, or projects discussed.

  Hey there, Sales Leaders and Professionals! Imagine a surprising twist in the world of sales culture that could skyrocket your team's performance. It's something unexpected, something that will make you rethink everything you know about building a winning sales culture. Stay tuned to find out what it is and how it can revolutionize your team's success. Ready to take your sales game to the next level? Let's dive in! Cultivating a sales culture Cultivating a strong sales culture is essential for fostering teamwork, accountability, and continuous improvement within sales teams. It involves creating a supportive environment where team members are empowered to collaborate, learn from each other, and strive for excellence. A positive sales culture boosts morale, increases motivation, and ultimately leads to enhanced performance and success. This is Paul Fuller's story: In this episode of The Modern Selling Podcast, Mario Martinez Jr. sits down with Paul Fuller, the Chief Revenue Officer of Membrain, a B2B growth platform. Paul brings over two decades of sales experience to the table, making him an expert in driving sales culture through character, competence, and technology. He emphasizes the significance of continuous training, individual accountability, and celebrating wins while coaching privately for improvements, laying the foundation for a positive sales culture. Throughout the episode, Paul shares valuable insights on providing constructive criticism in sales, the challenges of implementing sales technology, and the importance of proper training and enablement. With his deep understanding of the multi-faceted nature of sales and the impact of technology on driving sales culture, Paul offers practical advice to enhance team collaboration, accountability, and sales excellence. This engaging conversation is a must-listen for sales leaders and professionals looking to elevate their team's performance and build a strong sales culture. Paul Fuller found his calling in sales through a journey filled with diverse experiences. His career, which includes founding a sales-as-a-service company and transitioning to his current role, reflects his unwavering dedication to the industry. Paul's view of sales as a blend of leadership, service, and wayfinding sheds light on the profound insights he has gained over the years. His story is not just about professional growth, but a testament to how a shift in mindset can turn disdain for a profession into a deep-rooted passion. Paul's narrative resonates with the challenges and triumphs many professionals encounter, making his journey an inspiration for those seeking fulfillment and purpose in their careers. I think the biggest thing that we can help them do is be good at their job and be held accountable to doing it well. - Paul Fuller Our special guest is Paul Fuller Paul Fuller, the Chief Revenue Officer of Membrain, is a seasoned sales professional with over 22 years of industry experience. With a track record of leading a sales-as-a-service company and now steering Membrane's B2B growth, Paul brings a wealth of expertise to the table. His unique journey from initial skepticism about sales to recognizing its potential to transform lives gives him a distinct outlook on building a sales culture within teams. Paul's insights into leadership, service, and wayfinding in sales offer a refreshing and valuable perspective for sales leaders and professionals seeking to enhance team performance and foster a collaborative and accountable sales culture. In this episode, you will be able to: Mastering LinkedIn messaging will revolutionize your sales outreach. Weekly sales reports can uncover hidden opportunities and boost team performance. Cultivating a sales culture within your team is key to achieving sales excellence. Choosing the right sales technology can supercharge your team's productivity. Effective B2B sales coaching strategies can transform your team's performance.   The key moments in this episode are: 00:00:00 - Importance of LinkedIn messaging and leadership in sales 00:01:56 - Introduction to Membrain and Paul Fuller 00:03:13 - Membrain's B2B growth platform 00:07:43 - Personal definition of sales and its impact on people 00:11:20 - Delicate communication in addressing areas of improvement 00:13:47 - Building a Strong Sales Culture Based on Character and Competence 00:16:31 - Accountability and Approach in Sales Leadership 00:21:03 - Creating a Systematic Sales Culture 00:23:15 - Equipping Sales Teams with the Right Technology 00:27:55 - The Pitfalls of Misguided Enablement 00:42:35 - Challenges in Training 00:43:20 - Resistance to Change 00:44:50 - Impact of Membrain 00:49:13 - Connecting with Paul 00:50:52 - All-Time Favorite Movie Timestamped summary of this episode: 00:00:00 - Importance of LinkedIn messaging and leadership in sales The conversation starts with a discussion about the missed opportunity to reply on LinkedIn messaging and then delves into the importance of leadership in sales and the need for delicate communication in addressing areas of improvement. 00:01:56 - Introduction to Membrain and Paul Fuller Mario introduces Paul Fuller, the Chief Revenue Officer of Membrain, and they discuss Paul's background in sales and his role at Membrain. 00:03:13 - Membrain's B2B growth platform Paul explains that Membrain offers a B2B growth platform that includes a CRM and is designed to help sales experts and their customers define and execute their sales processes and methodologies. 00:07:43 - Personal definition of sales and its impact on people Paul shares his personal definition of sales as leadership, service, and wayfinding, emphasizing the impact of sales on changing people's lives beyond just financial gain. 00:11:20 - Delicate communication in addressing areas of improvement The conversation explores the challenge of providing constructive criticism in sales and the importance of building respect and trust to effectively communicate areas of improvement to sales professionals. 00:13:47 - Building a Strong Sales Culture Based on Character and Competence Paul emphasizes the importance of character and competence in building a strong sales culture. He stresses the need for true intentions and a heart of servitude in sales interactions. 00:16:31 - Accountability and Approach in Sales Leadership The discussion shifts to the approach and accountability in sales leadership. Paul talks about the importance of holding individuals accountable for their actions and celebrating wins while providing private coaching for improvement. 00:21:03 - Creating a Systematic Sales Culture Paul discusses the significance of creating a systematic approach to building a sales culture. He emphasizes the need for continual training, coaching, and the use of technology to enable sales teams to be effective in their roles. 00:23:15 - Equipping Sales Teams with the Right Technology The conversation delves into the importance of providing sales teams with the right tools and technology. Paul highlights the demoralizing effect of not arming teams with the right technology and emphasizes the need to align technology with the desired sales outcomes. 00:27:55 - The Pitfalls of Misguided Enablement The discussion covers the misconception of enabling sales teams with technology without understanding the specific job roles and desired outcomes. Paul emphasizes the need to avoid the "tech confusion gap" and align technology with the specific needs of each sales role. 00:42:35 - Challenges in Training Paul discusses the challenges he faced in training a large number of people and the lack of implementation and engagement from the trainees. 00:43:20 - Resistance to Change Paul addresses the resistance to change from the sales team, including their reluctance to use referrals and their low open rates and engagement on emails. 00:44:50 - Impact of Membrain Paul talks about the impact of Membrain on the market, including elevating the sales profession, driving excellence in the sales process, and achieving significant growth and client retention. 00:49:13 - Connecting with Paul Paul shares that the best way to connect with him is through LinkedIn and also mentions his podcast, "The Art and Science of Complex Sales." 00:50:52 - All-Time Favorite Movie In a lighthearted moment, Paul reveals that his all-time favorite movie is "The Goonies" and shares a fun memory related to it. Mastering LinkedIn messaging Mastering LinkedIn messaging is crucial for building connections and generating leads in the digital sales landscape. It involves crafting personalized messages that resonate with prospects and drive engagement. By harnessing the power of LinkedIn, sales professionals can reach a wider audience and establish meaningful relationships with potential clients. Unveiling the benefits of weekly sales reports Weekly sales reports offer valuable insights into team performance, allowing sales leaders to track progress, identify areas for improvement, and celebrate achievements. These reports provide a clear overview of key metrics, such as revenue goals, conversion rates, and pipeline growth, enabling data-driven decision-making. By analyzing weekly sales reports, teams can optimize strategies, enhance efficiency, and drive sales success. The resources mentioned in this episode are: Connect with Paul Fuller on LinkedIn by searching for Paul Fuller, Membrain or visiting LinkedIn.com/in/paulsfuller. Check out the Art and Science of Complex Sales podcast created by Membrain, available on all podcast platforms. Download FlyMSG at flymsg.io to save 20 hours or more in a month and increase productivity with a free text expander and personal writing assistant. Visit Membrain's website at membrane.com to learn more about their B2B growth platform and how it can help elevate the sales profession. Listen to the Modern Selling Podcast and give it a five-star rating and review on iTunes to support the show and help others discover valuable sales insights.

In this week's episode the Powell men discuss the latest debacle at the White House. #JuliusOrange #MangoMussolini #Twitler #DonaldTrump and his minion, butt boy,  #JDVance decided that they wanted to engange in a #WWF style tag team of #VolodymyrZelensky . #America has jumped the shark. We're no longer leader of the free world. We're #PutinsBitch . In other news, Derek reports that the #economicboycott was in effect at the #CIAA tournament down in #Baltimore . #AndrewCuomo is back and running for #NYCMayor #NYCMayor2025 . 

Dr. Pol Boudes, CMO of Rectify Pharmaceutical, highlights the importance of membrane proteins, specifically the role transporters play in how cells interact with their environment. Rectify is working on developing positive functional modulators (PFM) to address diseases related to dysfunctional transporters the first being primary sclerosing cholangitis, a rare liver disease with no current treatment options. The PFM can potentially restore the normal function of transporters involved in bile composition and secretion, which are key mechanisms in PSC.   Pol explains, "So you have different types of membrane proteins, but what we're working with are called transporters, so they're proteins that are based on the membrane but channel components out and in the cells. So basically, it's a way for the cell to interact with its environment, and you have multiple types of transporter proteins. We're specifically working or started to work with one group of family of proteins that are called the ABC transporters. They're a very important function, and they can either be disrupted because there is a mutation in the protein, so it's a genetic disease, or they are potentially disrupted because there is just a functional deficit of this transporter. The protein is normal, but it's not functioning properly. So it's a functional deficit of what we call the wildtype protein." "So with the PFMs, what we're doing is to use small molecules that you can administer orally, and they bind to the transporter, and by doing so, they can modify the three-dimensional structure of the transporter and consequently the way this protein behaves within the cellular environment. So we correct the function of the transporter by changing the size, if you want, of the shape of the transporter. So we started to focus on this type of proteins and you have many potential diseases due to transporter deficit."  "We're focusing on one disease, liver disease. That's our lead PFM for a disease called primary sclerosing cholangitis, which is a disease of the liver. This very severe liver disease is also a disease that has no treatment available, which is a little bit frustrating because the progression of this disease leads to liver cirrhosis. And the only thing you can do at this stage is liver transplantation. As you might know, liver transplantation is problematic because it's a very complex process, it's also very expensive, and unfortunately, there is a shortage of transplants. So we're trying to address this problem." #RectifyPharma #PrimarySclerosingCholangitis #PSC #RareDisease #LiverDiseases #BileProduction #Transporters rectifypharma.com Listen to the podcast here

Dr. Pol Boudes, CMO of Rectify Pharmaceutical, highlights the importance of membrane proteins, specifically the role transporters play in how cells interact with their environment. Rectify is working on developing positive functional modulators (PFM) to address diseases related to dysfunctional transporters the first being primary sclerosing cholangitis, a rare liver disease with no current treatment options. The PFM can potentially restore the normal function of transporters involved in bile composition and secretion, which are key mechanisms in PSC.   Pol explains, "So you have different types of membrane proteins, but what we're working with are called transporters, so they're proteins that are based on the membrane but channel components out and in the cells. So basically, it's a way for the cell to interact with its environment, and you have multiple types of transporter proteins. We're specifically working or started to work with one group of family of proteins that are called the ABC transporters. They're a very important function, and they can either be disrupted because there is a mutation in the protein, so it's a genetic disease, or they are potentially disrupted because there is just a functional deficit of this transporter. The protein is normal, but it's not functioning properly. So it's a functional deficit of what we call the wildtype protein." "So with the PFMs, what we're doing is to use small molecules that you can administer orally, and they bind to the transporter, and by doing so, they can modify the three-dimensional structure of the transporter and consequently the way this protein behaves within the cellular environment. So we correct the function of the transporter by changing the size, if you want, of the shape of the transporter. So we started to focus on this type of proteins and you have many potential diseases due to transporter deficit."  "We're focusing on one disease, liver disease. That's our lead PFM for a disease called primary sclerosing cholangitis, which is a disease of the liver. This very severe liver disease is also a disease that has no treatment available, which is a little bit frustrating because the progression of this disease leads to liver cirrhosis. And the only thing you can do at this stage is liver transplantation. As you might know, liver transplantation is problematic because it's a very complex process, it's also very expensive, and unfortunately, there is a shortage of transplants. So we're trying to address this problem." #RectifyPharma #PrimarySclerosingCholangitis #PSC #RareDisease #LiverDiseases #BileProduction #Transporters rectifypharma.com Download the transcript here

On this week's episode of Critical Care Time, we sit down with two brilliant early-career ECMOlogists for an “intro-plus” to VV and VA ECMO. Not only do we cover the basics, but we couldn't help ourselves and went on some deep dives along the way that you guys will hopefully find interesting! With the help of our good friends Nick Villalobos and Kha Dinh, we review indications for ECMO, approaches to configuration and management, touch on some of the complications and… even spend some time demystifying the European unit for girth! We hope you guys will have as much fun listening to this as we did producing it. If so, leave us a review and let us know what you think! Hosted on Acast. See acast.com/privacy for more information.

Send us a textThis episode is a little different than most. Instead of skipping this week, we decided to give you a short episode because we have some exciting news! Tune in to hear about, the hardest pack Jameson has ever made, stories from behind the scenes of our newest fabrics, as well as the details on our maker meet up next month. New Products: Shop the New Year New Gear Sale https://ripstopbytheroll.com/pages/new-year-new-gear-2025210D Venom™ Gridstop ECO  https://ripstopbytheroll.com/products/210d-venom-gridstop-eco?rfsn=7912242.9c073860.9 oz MEMBRANE 15 ECO Ripstop Nylon https://ripstopbytheroll.com/products/0-9-oz-membrane-15-ripstop-nylon-calendered-eco?rfsn=7912242.9c073865.1 oz Lycra PowerMeshhttps://ripstopbytheroll.com/products/lycra-powermesh?rfsn=7912242.9c073864.0 oz Pocket Meshhttps://ripstopbytheroll.com/products/4-0-oz-pocket-mesh?rfsn=7912242.9c07386Fan Mail Questions: Youtube link for Derrick Hansen episode https://www.youtube.com/watch?v=U8nJl4_n2k8Find Us on Social Media

The Alan Cox Show

The Alan Cox Show

We can't believe we have arrived at the last episode of 2024! This year has brought so many incredible and empowering births. We loved hearing how each of you fought for your birth goals, magnified your voices, and showed your strength. In today's episode, Meagan sums up The VBAC Link's 2024 achievements and shares some of the exciting things she has in store for 2025. The VBAC Link Supportive Provider ListThe VBAC Link Doula DirectoryHow to VBAC: The Ultimate Prep Course for ParentsFull Transcript under Episode Details Meagan: Hey guys, it's Meagan. Guess what? Today is our last 2024 episode. I cannot believe it is the end of the year. I absolutely cannot believe it. It feels like just yesterday that we started doing two episodes a week, and here we are 11 months later. We started in February. You guys, it has been such a great year. We have had so many incredible episodes from placental abruption, faith over fear, breech VBACs, post-dates, what hospital policies mean,and National Midwifery Week. One of my favorites, well actually, two of my favorites because he came on twice, was Dr. Fox. We had Dr. Fox a couple of times. We've had doula tips from VBAC episodes. We've had some fun episodes where we've had some VBAC Link-certified doulas as cohosts. Oh my gosh, so many great things. I don't know if you noticed, but in October, we started doing a themed week. Every two episodes in one month was a theme. For October, we had midwifery. It was National Midwifery Week so we talked about midwives and the stats about midwives. We had CNM Paige come on with our very own Lily who talked more about midwifery care, what does it look like, how to choose, can a midwife support VBAC, and all of that fun, fun stuff. And then in November, it was Veteran's Day so we had some military mamas on there and more about how to navigate that. We talked a little bit about Tricare and tips about navigating birth as a servicemember or as a significant other. That was really, really fun.This month, we touched on uterine abnormalities. We had Flannery talking about her bicornuate uterus and more about specific types of uteruses and what that means. It's so weird to think, but there are different types of uteruses, you guys. That doesn't mean that if you have a different type of uterus that you can't VBAC. It may mean that you may be faced with some challenges like a breech baby or something like that, but we wanted to share more about that because that's not talked about. But it's not going to stop. We have got that coming all year. 2025 is going to have a lot of really fun, specific episodes. The reason why I did this is because I wanted to have a whole week in two episodes where people could come and just binge two specific episodes that they may be looking for. We have a lot of people writing in saying, “Hey, I'm looking for VBAC after multiple Cesareans. Hey, I'm looking for breech stories. Hey, I would like to hear more healing CBAC stories or planned Cesarean stories.” We wanted to have it so they could just do two episodes back to back.Then of course, there are episodes throughout the whole podcast that we have that you can go back and find, but this way, you can find it in one week, two episodes back to back. We've got things like CBAC coming, VBAC after multiple Cesareans. We've got breech. We've got OB week. That's going to be fun. Oh man, I'm trying to think. So many other things. Special scars. We have a special scars month. We are just going to have months where it's typically going to be that second week where it will be a specific theme and topic. Don't forget to check that out coming up in 2025. Like I said, we started that up in October. Okay, so some other really fun and exciting things coming up, I do have a surprise for you, but unfortunately, you're going to have to wait until 2025. I'm really excited for this series. Yeah. It's going to be so good. Make sure to come back next week in 2025 to learn more about a surprise that I have coming your way. Then, in addition to that surprise and our themed weeks, I'm actually going to be rebroadcasting some of our old episodes. As you know, we are getting up there. We are at 365 episodes today which is so dang exciting. I cannot thank you guys enough for continuing to support this podcast, for coming back, listening, downloading these episodes, and just being here with us. We see you in our community on Facebook. We see you on Instagram. We see you downloading and listening. We are getting messages in regards to these stories and how much they are connecting with people.You guys, these stories are incredible. Just a reminder also, we are always accepting submissions. Now, we can't get to every submission because we do get a lot of submissions which is so fun to go through. We share them on our social media if we can't sometimes share them on the podcast, but please, if you have a story that you would like to submit and share them with other Women of Strength who are coming after you and are wanting to hear these empowering messages, go to thevbaclink.com/share, I believe, and submit your podcast story. Okay, going back. We are rebroadcasting episodes. I have gone back and listened to probably 10 or 12 episodes. Some of our really, really amazing episodes, and I've found some nuggets after re-listening that I'm pulling through and giving tips. We're going to have extra tips, extra links, and also if there have been updated things or updated studies from 2018 that have now been updated, we want to make sure that we freshen up these episodes and bring them back to more recent episodes. If you have a favorite episode that you would like to hear rebroadcasted or one that you listen to on repeat, will you let us know? Email us at info@thevbaclink.com and let us know what your favorite episode is and why, or if you are looking for some more information or want us to elaborate more on a topic that maybe we have discussed but didn't go too far into detail that I can maybe go into deeper detail about. Okay, I'm trying to think, you guys. We've had so many amazing things this year. Blogs– we have been pumping out blogs like crazy. There are so many things from preparing for your VBAC, 5 things to do before you get pregnant, recovering from a Cesarean birth. You guys, if you've been with us for a while, you know we absolutely love and adore Needed. We wholeheartedly love and trust everything they produce. We love them. They have really been so gracious to offer us a wonderful 20% off discount code, so don't forget that. That is still valid. You can go to thisisneeded.com and type in VBAC20 and get 20% off your order. We talk more about why prenatal nutrition matters. We talk about creating your ideal hospital environment. We talk about C-section scar massage and why it's important. That is a big one that isn't talked about enough. We talk about hiring doulas, things to put on your registry, more about red raspberry leaf tea. We talk about heartburn, Tums, and also what else Tums can do to help us in our VBAC. So many things. We talk about positions and using the ball. Oh my gosh, just so many incredible things. We've got so many blogs coming at thevbaclink.com/blogs so make sure to check out the blog and learn more about these topics. Membrane sweeps, VBAC after multiple Cesareans, uterine rupture, if you're looking for that VBAC provider, definitely check out that blog about how to find out if you need to switch your provider. Then of course, we have our VBAC course. You guys, I love our course so much. Another big reason why we are going to be re-airing our episodes is so that we can keep updating our course. Birth in general is updating all of the time. This course– Julie and I created it a long time ago, and it is my baby. I am so excited for this course because I have seen so many people get the information that they need, feel more empowered and equipped to have a VBAC, then we actually have a birth worker course. The birth worker course is to certify VBAC doulas, our birth workers, and it is accredited. It is 8 ICEA credits, so if you have a doula that hasn't been in our course yet,  maybe suggest that to them or if you are a birth worker listening, I highly suggest it. We have a VBAC Link Doula directory, so if you are looking for a doula or, like I said, you are a birth worker and you want to be found, we want to help you be found. You can find a doula at thevbaclink.com/findadoula, and if you are a birth worker, you can check out your area. California, I know needs more doulas. Texas, there are a lot of states that need more doulas. We would love to add you to your family.Okay, you guys. I'm trying to think what else. Oh my gosh. I could not leave without saying this. This year, we updated our provider list. It is on Instagram. You can go the The VBAC Link at Instagram. Click on our linktree in our bio, and it is the top one to find a supportive provider in your area. Now, if you have a provider that should be on this list or if you are a provider and wantt o be on this list, please email us at info@thevbaclink.com or you can email us on Instagram so we can get your provider listed. We really need providers who accept VBAC after multiple Cesareans, breech VBAC, and who are just VBAC supportive in general. You guys, it is so stinking silly and stupid how hard it is to sometimes find a provider. Please check out that form. If your provider is supportive, please, please, please let us know so we can get them listed. Okay, you guys, I think that is about everything. It has been such a great 2024. I am so grateful again for you guys. I hope you will continue to join us for 2025 because we do have more incredible episodes coming your way from a lot of VBA2Cs. We have polyhydramnios (high fluid). We have HBACs. We have CBACs. We're going to have a couple of OBs actually and special scars. So many great things. We will catch you in 2025. I hope you guys have a fantastic new year. ClosingWould you like to be a guest on the podcast? Tell us about your experience at thevbaclink.com/share. For more information on all things VBAC including online and in-person VBAC classes, The VBAC Link blog, and Meagan's bio, head over to thevbaclink.com. Congratulations on starting your journey of learning and discovery with The VBAC Link.Support this podcast at — https://redcircle.com/the-vbac-link/donationsAdvertising Inquiries: https://redcircle.com/brands

I read from ferry to fertilization membrane.     The word of the episode is "fertilization membrane". https://en.wikipedia.org/wiki/Vitelline_membrane     Use my special link https://zen.ai/thedictionary to save 30% off your first month of any Zencastr paid plan.    Create your podcast today! #madeonzencastr     Theme music from Jonah Kraut https://jonahkraut.bandcamp.com/     Merchandising! https://www.teepublic.com/user/spejampar     "The Dictionary - Letter A" on YouTube   "The Dictionary - Letter B" on YouTube   "The Dictionary - Letter C" on YouTube   "The Dictionary - Letter D" on YouTube   "The Dictionary - Letter E" on YouTube   "The Dictionary - Letter F" on YouTube     Featured in a Top 10 Dictionary Podcasts list! https://blog.feedspot.com/dictionary_podcasts/     Backwards Talking on YouTube: https://www.youtube.com/playlist?list=PLmIujMwEDbgZUexyR90jaTEEVmAYcCzuq     https://linktr.ee/spejampar dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://www.threads.net/@dictionarypod https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar https://www.tiktok.com/@spejampar 917-727-5757

Differences in ion concentrations inside and outside a cell cause a difference in the charge of the intracellular and extracellular environments. This electrical polarization of a cell relative to its environment is referred to as cellular membrane potential. This potential serves as an energy source for a variety of cellular functions and as a way for excitable cells like muscle cells and neurons to communicate their signals. A cell controls its membrane potential by regulating the concentration of multiple ions and other charged particles. Let's take a closer look at the biochemistry behind the cell membrane potential. After listening to this AudioBrick, you should be able to: Define equilibrium and describe the forces at work on ions across a biological membrane. Discuss the importance of the Nernst equation and equilibrium potentials. Describe the importance of Na-K-ATPase in relation to the resting membrane potential (Vr). Describe the nonequilibrium steady-state (NESS). Define and discuss the chord conductance equation. You can also check out the original brick from our Cellular Biology collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology. *** If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/

This week, Scott was joined by his Lawfare colleagues Eric Ciaramella and Anastasiia Lapatina, as well as special guest Kyiv Independent reporter Francis Farrell, for an episode committed to one big topic: what Trump's return to the White House might mean for Ukraine. They tackled the issue in three parts:“What Condition My Attrition Is In.” By most accounts, after more than two years of fighting, the conflict in Ukraine has come to look very much like a war of attrition. How do Ukrainians feel about the state of the conflict and the prospects looking forward? What steps are the outgoing Biden administration taking to change the calculus—and what impact might they still have, if any?“New Boss, Same as the Old Boss.” Donald Trump's return to the White House promises a sea change in how the United States has approached the conflict in Ukraine. What do his early national security appointments—and engagements with, among others, Ukrainian President Volodymyr Zelensky—tell us about his plans? And where do they seem likely to lead?“Flipping the Board.” Trump's election—and whatever outcome he is able to bring about in Ukraine—has the potential to reset the strategic environment in Europe (and the U.S. strategic relationship with Russia) more generally. What might regional security—and security for Ukraine specifically—look like by 2028?For object lessons, Nastya recommended Catherine Belton's new book, “Putin's People,” on the return and rise to power of the KGB. Eric gave a belated endorsement for the Oscar-winning South Korean film “Parasite,” and urged folks to watch it as a celebration of the democratic resilience South Korea demonstrated this week. Scott plugged the holiday variety show he was attending that evening and urged listeners to welcome the season with Aimee Mann's “One More Drifter in the Snow.” And Francis recommended GeoGuessr, the geolocation game that has taken the KI newsroom by storm.Rational Security will be saying goodbye to 2024 in its traditional fashion: by discussing listener-submitted topics and object lessons! To submit yours, call in to (202) 743-5831 to leave a voicemail or email rationalsecurity@lawfaremedia.org. Just do it by COB on December 18!To receive ad-free podcasts, become a Lawfare Material Supporter at www.patreon.com/lawfare. You can also support Lawfare by making a one-time donation at https://givebutter.com/lawfare-institute.Support this show http://supporter.acast.com/lawfare. Hosted on Acast. See acast.com/privacy for more information.

This week, Scott was joined by his Lawfare colleagues Eric Ciaramella and Anastasiia Lapatina, as well as special guest Kyiv Independent reporter Francis Farrell, for an episode committed to one big topic: what Trump's return to the White House might mean for Ukraine. They tackled the issue in three parts:“What Condition My Attrition Is In.” By most accounts, after more than two years of fighting, the conflict in Ukraine has come to look very much like a war of attrition. How do Ukrainians feel about the state of the conflict and the prospects looking forward? What steps are the outgoing Biden administration taking to change the calculus—and what impact might they still have, if any?“New Boss, Same as the Old Boss.” Donald Trump's return to the White House promises a sea change in how the United States has approached the conflict in Ukraine. What do his early national security appointments—and engagements with, among others, Ukrainian President Volodymyr Zelensky—tell us about his plans? And where do they seem likely to lead?“Flipping the Board.” Trump's election—and whatever outcome he is able to bring about in Ukraine—has the potential to reset the strategic environment in Europe (and the U.S. strategic relationship with Russia) more generally. What might regional security—and security for Ukraine specifically—look like by 2028?For object lessons, Nastya recommended Catherine Belton's new book, “Putin's People,” on the return and rise to power of the KGB. Eric gave a belated endorsement for the Oscar-winning South Korean film “Parasite,” and urged folks to watch it as a celebration of the democratic resilience South Korea demonstrated this week. Scott plugged the holiday variety show he was attending that evening and urged listeners to welcome the season with Aimee Mann's “One More Drifter in the Snow.” And Francis recommended GeoGuessr, the geolocation game that has taken the KI newsroom by storm.Rational Security will be saying goodbye to 2024 in its traditional fashion: by discussing listener-submitted topics and object lessons! To submit yours, call in to (202) 743-5831 to leave a voicemail or email rationalsecurity@lawfaremedia.org. Just do it by COB on December 18!To receive ad-free podcasts, become a Lawfare Material Supporter at www.patreon.com/lawfare. You can also support Lawfare by making a one-time donation at https://givebutter.com/lawfare-institute. Hosted on Acast. See acast.com/privacy for more information.

 The FHB crew talks about hunting down noisy insect, the pros and cons of rubber and PVC roofs and insulating them without creating problems. They also discuss insulating and waterproofing stone foundations. Tune in to Episode 658 of the Fine Homebuilding Podcast to learn more about:  A simple method for catching indoor crickets Insulation strategies for EPDM and PVC membrane roofs How to install insulation on a stone foundation  Have a question or topic you want us to talk about on the show? Email us at fhbpodcast@taunton.com.     ➡️ Check Out the Full Show Notes: FHB Podcast 658 ➡️ Learn about SketchUp for Builders by Jon Beer, the new E-learning course from Fine Homebuilding ➡️ Follow Fine Homebuilding on Social Media:   Instagram • Facebook • TikTok • Pinterest • YouTube  ⭐⭐⭐⭐⭐  If you enjoy the show, please subscribe and rate us on iTunes, Spotify, YouTube Music, or wherever you prefer to listen.

On today's episode I am sitting down solo to share the candid details of my birth story of my beautiful daughter Amelia! I wanted to share my birth story alongside some details of my early days postpartum because when I was about to go through this experience, it was so hard to find podcast episodes and information like this of women who had hospital births, opted for an epidural and also an induction. And because I had a positive experience, I wanted to share exactly what it was like with you! This is a very special episode as I recount the raw emotions starting at 39 weeks pregnant leading up to Amelia's delivery, what I've learned about motherhood thus far and the unexpected things I've learned during this incredibly transformative time. I hope my story resonates and sheds light on the diverse and extraordinary experience of childbirth. To connect with Lauren, click HERE  Submit your question for advice from Lauren on the show HERE  Take the free Weight Loss Personality Quiz HERE  Shop Our Meal Plans HERE  Get Support & Personally Work With Us HERE  Related Episodes:

Katie is a newborn and family photographer based out of Chicago. After going through IVF, Katie was surprised to find out that her first pregnancy was with identical twins. At 33 weeks, she had an unexpected bleed and then another at 35 weeks. Because of placental abruption, she went straight to a Cesarean and her babies were in the NICU for 7 days.Katie wanted to know what a singleton pregnancy and VBAC birth could be like. She found a supportive midwife group through her local ICAN chapter that had around a 90% VBAC success rate! She also hired a doula. As her due date approached, Katie decided to opt for membrane sweeps to avoid a medical induction starting at 38+6 weeks.After four membrane sweeps over the course of two weeks, spontaneous labor began. She arrived at the hospital and her sweet baby was born vaginally just 5 hours later!Though she said she has a low pain tolerance, Katie's VBAC was unmedicated and she also shares her experience with a retained placenta and a second-degree tear. Katie, that is no small feat-- we know you are an absolute warrior and woman of strength!How to VBAC: The Ultimate Prep Course for ParentsFull Transcript under Episode Details Meagan: Welcome to the show, Katie. Thank you so much for being here with us. You guys, Katie is from Chicago, right? Chicago. Katie: Yep. Meagan: She is an IVF mama. She's got three girls. She is a girl mom and two identical twins and then a baby girl. How old is your baby girl now? Katie: She's going to be 3 months tomorrow. Meagan: 3 months so still little tiny. Oh my gosh. I love it. So yeah, and then you guys, when she's not doing the mom thing with all of her girls, she is also a newborn and family photographer which is awesome. Can you share with us your handle so we can come follow you?Katie: Yeah. On Instagram, I'm at katiemichellestudios. Meagan: Okay, katiemichellestudios and we are going to make sure to have that in the show notes so you can go follow her and follow her amazing work. And if you're in Chicago and you need newborn or family photos, hit her up. Is there a specific– Chicago is big. Is there a specific area that you serve?Katie: I'm in the northwest suburbs but I do in-home sessions wherever. I use a studio in Oak Park. Meagan: Okay, awesome. Then with your stories today, we've got a couple of highlights. We have IVF, placental abruption, and sticky placenta. I'm excited to talk about sticky placenta for sure because it's not something a lot of people talk about that could happen. Then, of course, the twins and all of that. We are going to get into that but I do have a Review of the Week. You guys, I know every single week I know you are probably sick of me asking but I love your reviews. Thank you so much for your reviews and remember, we always accept your reviews. Okay, this is from cassie80. It says, “Extremely educational and super empowering.” It says, “After a traumatic C-section in 2016, on my research journey about VBAC, I came across this podcast and instantly fell in love.” You guys, that just says something to me. 2016 is when she had her C-section and 2018 is when this podcast started. It's crazy to think that it's been going for so long but I'm so grateful for all of you guys sharing your stories like you, Ms. Katie, and helping this continue. It says, “I am currently trying for number two and am on a mission to VBAC. Hearing all of these wonderful stories of strength has given me the confidence that I can do it when the time comes. You and all of the women who courageously share their stories are just amazing. You all provide healing and support for all of us mamas.” Thank you so much, Cassie, and I'm so glad that you are here with us and have been with us for so long. Okay, Katie. Thank you again for being here. Katie: Thank you so much. I am so excited to be on this podcast myself because I listened to you guys nonstop my entire pregnancy even before and I always had it in the back of my mind that, Oh, if I get my VBAC, I'm going to come on here and tell my story. I am super excited and thank you for having me. Meagan: Oh my gosh, thank you so much. Let's talk about these twins. Let's talk about that birth. Katie: Yes. They were IVF but they were obviously surprise identical twins. My embryo split into obviously identical twins but they were an interesting pregnancy because usually with IVF, the twins are mono-di which means they share a placenta and have two sacs but my girls are actually di-di so they had two placentas, two sacs, so that meant they were a little bit less of a risky pregnancy and a vaginal birth was a possibility. That's what I was planning on. Everything was pretty smooth up until 33 weeks which is when I had my first bleed. It was just the middle of the night. I got up and I just started gushing. The doctor said that it was a marginal placental abruption. That means it was on the edge of the placenta and it wasn't a risk to them. Obviously, it was super scary. I thought that I was going to lose them both but everything with them was fine. They sent me home after a few days at the hospital. They just told me to take it easy, but they said it might happen again. It did at 35 weeks and 3 days. I had another bleed. At that point, they said, “They are almost to term for twins.” It's technically 37 or 38 weeks is when they like to induce for twins so they just said not to risk going any further and let's just get them out right now. I was planning on a vaginal birth, but because of that abruption and we didn't know what state the placenta was in and what would happen if there was an induction process that was started, so with the doctors, we decided I didn't want to risk induction and then needing a C-section anyway for the other twin so we did the C-section. It was a really, really rough recovery and they were in the NICU for a week. One of them needed breathing support and the other one was there for growing and feeding. Meagan: How big were they?Katie: 5 pounds, 3 ounces, and 4 pounds, 13 ounces. Meagan: Okay, okay. Katie: They were a good size. They were overall healthy but it was for me, super duper rough as a first-time mom to twins especially. The breastfeeding journey was really hard. I dealt with low milk supply and they were so tiny that it was hard for them to latch so I ended up exclusively pumping for 11 months. That's their story. Meagan: Wow. That's a lot of work by the way for someone maybe who hasn't pumped a lot. Holy cow. Good job. Katie: Yeah. So when we decided to have a third which was a tough decision for us, my husband was not on board. We ended up deciding that we wanted to experience what it's like to have a singleton baby and just having a singleton pregnancy hopefully and a VBAC. I definitely knew that I wanted a VBAC and started doing all my research. I found a very VBAC-supportive midwife group in my area. They have a 90-something percent VBAC rate in the hospital which is crazy. Meagan: Wow, yeah. That's amazing. What do you think they do so differently that a lot of other groups don't do that makes them so successful? Or are you going to share about it?Katie: I'm not sure. I think the hospital might be part of it, like the hospital policies might be more supportive. They deliver at Evanston Hospital if anyone is interested. Overall, I think the doctors that they work with because it's a midwife group that they work alongside doctors that when there is a delivery for the midwives, the doctors are also in the hospital. I think the doctors are also very VBAC-supportive so I think that helps when they are working together. Meagan: Yes, absolutely. Katie: That's that story. Meagan: So you found them. You found the providers. Did you go and ask them questions? How did you feel like you realized that they were supportive? Katie: Yeah. I went on– what's that group that have a Facebook group all around the country for different areas about lowering the C-section rate?Meagan: Oh, cesareanrates.org? Katie: I'm not sure. They are an organization. Meagan: Oh, ICAN?Katie: ICAN, yes. I went on my local Facebook group for ICAN and I asked around. I got their info. I first went for an appointment with one of the doctors at that practice before I was even pregnant because I was planning for the transfer and I liked that doctor, but then I realized that they have midwives and people really raved about the midwives. They said if you are looking for a more holistic experience and they spend more time with you than the doctors do. I just decided to go that route and somehow picking the midwives made me dive into the whole unmedicated birth side of things as well. I ended up hiring a doula as well. I never thought I'd be someone interested in unmedicated birth. I consider myself to have very low pain tolerance. Meagan: So tell us more about the birth. You have a low pain tolerance but you did go unmedicated?Katie: Yes. I ended up doing it. Meagan: Okay. Did you go into spontaneous labor?Katie: Yeah, it was interesting. I ended up having four membrane sweeps which is not that spontaneous. Meagan: Well, hey. This is the thing. A lot of people ask about membrane sweeps and sometimes people feel, Hey, this is worth it. Let's do this. Some people don't. Sometimes it works and sometimes it takes many and sometimes it doesn't. It's whatever feels right. So do you remember where you were with the first membrane sweep cervical-wise and how many weeks and things like that? Katie: Yeah, so I wanted to start them. Remember, I had never been pregnant past 35 weeks. Meagan: Right, yeah. Katie: I really thought that I was going to have an early baby again, but that really wasn't the case. I had her at 40 and 5. So the membrane sweep, I started the first one at 38 and 6 so basically at my 39-week appointment. I had no change after that one. Nothing happened. That's kind of what I assumed would happen so I had another one the next week at 39 and 6 and at that point, I was 2 centimeters, 80% effaced, and -1 station. Meagan: Okay, so pretty good cervical statistics there for a membrane sweep. Katie: Yeah. So then it was my due date and I was starting to feel more pressure. The mucus plug was coming out and baby was acting super active which I heard can happen close to when a baby is ready to be born but nothing really happened at that point. So then I decided to get my third sweep. I think that was 40+2 and at that point, I was 2.5 centimeters but the same for everything else. But things were starting to happen. I was having more stuff come out and I was like, Oh my gosh. How much longer am I going to be pregnant? Meagan: I'm sure. This is the thing. When you had either preterm or just early deliveries before and then you go past that, it feels like, No. I cannot be pregnant longer than this. This is eternity. Katie: Yes. It was really hard because I had the two-year-old twins also. It was getting to be a real mental and physical struggle. Meagan: Yes. Yeah. Katie: Also, I was doing pumping to try to induce labor and that wasn't doing anything. Meagan: Yeah. Was it causing contractions at all or was it just causing them and then you'd stop and it would stop?Katie: Yeah, basically it would just cause the Braxton Hicks contractions and nothing else. Meagan: Then it would go away. Katie: Yeah. So I had my third sweep and that one really started to do something because I went into prodromal labor which was a doozy. Meagan: Yeah. You know, that can be a risk of trying a membrane sweep. It can cause some prodromal labor but again, a lot of the time, prodromal labor still does stuff. It's tiring and it's exhausting but it's still doing something. Katie: Yeah, and it definitely did for me. My prodromal labor was a nighttime thing. The sun would go down. I'd put the kids to bed and it would start with irregular contractions. It felt like period cramps then I wouldn't sleep all night with that. I had that for two nights and then I was finally– Meagan: Typical prodromal. Katie: Then it would go away during the daytime. Meagan: It's so annoying. It's like, seriously? Fine. If you're going to do prodromal, at least do it during the day when I'm awake but don't take away my sleep. Katie: I know. At that point, I was getting super disheartened. I decided to schedule my induction because if this was going to happen every night, I would have zero energy for this VBAC. I did schedule my induction for 41 and 3 I believe if I made it to that point but I decided to go back and get my fourth membrane sweep June 3rd so the day before she was born. That started something. The midwife was like, “Okay, if I do this, I might see you back here later tonight.” Meagan: That's a promising thing to hear. Katie: Yeah, so once she did that sweep, I was actually already 4.5 centimeters dilated. That prodromal labor was doing something. Meagan: Um, 100%. Katie: Yep. That morning I had that sweep. We went to get lunch. We walked around. I was starting to right away have contractions and these were during the day so I knew something was up. By 4:00 PM that day, I was feeling it. I was starting to need counterpressure and had to stop what I was doing. Based on what the doula had said, that was when I should call them. I texted her and I told her, “I'm having these contractions that I'm having to stop and breathe through but they are still 10 minutes apart so I don't know what's going on.” She's like, "Okay. I think you need to stay home a little longer. You're probably not in active labor yet.” I'm like, "No, I think I'm there. Things are really intense.” Despite what she said, I headed to the hospital.It's a good thing I did because by the time I arrived at 10:00 PM, I was already 6.5 centimeters. Meagan: Okay, nice. Katie: I was very surprised because usually what the doula community says is sometimes when you head to the hospital when you are not in active labor, things can slow down because of the change of scenery and yeah, your body just shuts down. But in my case, it actually was the reverse. I went from super irregular contractions to walking up to the hospital doors and they started coming super regularly like 2-3 minutes apart. Yeah. Meagan: I do feel like the opposite can also happen where our body gets to that final destination and it's like, Okay. You can do this now. You have this sense of release. What you were saying, yes I've seen that too where the mom has to reacclimate to the space and labor stalls a little bit then it goes on, but this one it sounds like it was the opposite where it maybe brought you relaxation and safety. Katie: Yeah. I think maybe part of it was that this hospital experience was so different than my last one. At the last one, it was rushing to the hospital while I'm bleeding. I get there and there's this rush of nurses. Everyone's checking me and this time, I waddled up to the hospital. The room was dark. There was one nurse checking me in. I'm just chilling on the bed. I was just relaxed. I think a lot of the things that I did with the doulas to prepare, like they did classes about comfort measures and things like that and I was really trying to use those. I got the twinkle lights set up and got the music so that really helped. By 1:00 AM, I was already feeling the urge to push and I was feeling so much pressure, especially in my butt. I needed counterpressure for every single contraction up to that point then I was like, “No more counterpressure.” I was screaming for my husband to stop doing it because it was starting to hurt. I knew that something was happening. I was on my side trying to get some rest in between and I was starting to give up at that point. I know what they say is when you are starting to give up, you're starting transition. Meagan: You're right there. Katie: For me, I was thinking, I need an epidural right now. Meagan: A lot of people do though. A lot of people are like, “I can't do this anymore. I'm done. That's that. I need that epidural. I need relief now.” Katie: Yep. I hadn't had a check since I was admitted. It had been about 5 hours since I showed up or 4 hours since I showed up to the hospital so I was like, This can't be it. I can't be ready to push because I've only been here 4 hours and it's my first labor. I was in disbelief but I was like, “I need a check right now because if I'm not close to pushing, I'm getting the epidural.” The doula was trying to talk me out of it. She was like, "Are you sure? What are you going to do if you're not there?” I'm like, "I'm going to get the epidural.” I was 9.5 centimeters at that point. Meagan: Oh yeah. Right there. Katie: Yeah, and I was like, "Oh my gosh. This is actually happening.” My body was starting to push on its own and it was such a weird feeling. It was so different than my friend's birth that I photographed. She had an epidural and it was an induction. That's the only other birth that I've seen and this was so different because my body was pushing. I can't control it. Yeah. That was about an hour of pushing which felt like an eternity and the contractions were actually fine at that point. I couldn't feel them. I could just feel loads of pressure and the ring of fire which was intense, super duper intense. Then my water broke about 10 minutes before she was born and yeah, she was born. Meagan: You get to 10, your water is probably going out through breaks and baby comes down. Katie: Yeah, I had a bulging bag at the end which is really interesting to feel. She was born at 2:34 AM. Meagan: Aww, that's awesome. So pretty dang quick. Katie: Yeah. If you don't count the two nights of prodromal labor. Meagan: Prodromal labor, yeah. But your body was doing it slowly and surely. Each sweep did give you that extra nudge. It maybe gave you some prodromal labor along the way, but it seemed like it was helping and doing something. Katie: Yeah, if that helped me avoid a medical induction, I'm super glad that I did those. Meagan: Yeah, that's something when it comes to someone facing an induction or facing that hurdle, a membrane sweep might not be a bad idea. But too, with that said, if we go in and we are barely 1 centimeter or our cervix is really posterior and we are 30% effaced, we need to know mentally that if we go for a sweep, the chances of it working is a lot lower. It's just lower because our body is maybe not ready. It also doesn't mean it's not going to work. So like I said earlier, you had that ideal cervical stat. You were that 2 centimeters and 80% effaced. Things were looking good and softer, starting to open and they were able to get a really good sweep but even then, it took time. Katie: Yeah, definitely. My midwives never pressured induction on me. I was pressuring myself mainly because IVF pregnancies– there are differing opinions but some doctors say that you should be induced at 39 weeks and some say you shouldn't go past your due date because of the placenta not being as good. Meagan: Well, yeah. It's so hard because– so twins were IVF and was this baby IVF too?Katie: Yeah. Meagan: Okay, that is hard because there are a lot of people who do say that you should induce at 38-39 weeks with IVF and we do know out there that with IVF, the chances of having placenta issues and abnormalities like abruption are increased. Accreta, previa, and things like that. But if everything is going okay, all is looking well, it's that battle of do we induce? Do we not induce? What do we do?Obviously, your providers weren't pushing it so they didn't see any real medical need but then we have other providers on the complete opposite end where they are pushing it hard. Katie: Yeah, in some of my IVF groups on Facebook, basically every single person is induced or has a C-section. It's pretty rare for a provider to say you can go to 42 weeks like mine did. Meagan: Interesting. I actually don't know the real stats on IVF placental issues after 38 weeks. Had anybody ever talked to you about what your chance of issues really were after a certain point?Katie: No. The abruption was I think more of a risk factor was that it was twins and my uterus was so stretched but no one really mentioned placental issues or even said, “Let's look at your placenta after 40 weeks.” They do have the standard ultrasound to look at baby and do the BPP test, but they said that there is nothing really you can see from an ultrasound after your due date. Meagan: We know that ultrasounds can be off by size and by all the things. Katie: Yeah, and she was measuring bigger. She was 85th percentile which was actually true. She was born 8 pounds, 4 ounces so she wasn't tiny like my twins were. Meagan: Yeah. I Googled really, really quickly. This isn't even a study. This is just an article on it. I'll try to get some more studies and things in here but I'm going to include this article. It's from the Real Birth Company. It looks like they are teachers of birth classes. It's highlighted. It says, “What do you need to know if you are pregnant through IVF and you're being advised to have an induction because you are told that there is a higher chance of stillbirth?” It says, “The only study that we found that gives us the information also noted at higher risk of stillbirth for IVF pregnancies, but crucially, they said no increase in their rate of stillbirth after 28 weeks of pregnancy. It just says, “This research therefore tells us that induction at terms would not necessarily reduce stillbirth rates for babies who are conceived by IVF.”Katie: Yeah. From my understanding, it's hard to do studies on this because a lot of women who need IVF have other health factors which can increase the risk of obviously stillbirth and other issues in pregnancy. Meagan: Yeah, it's showing that sometimes IVF moms have placenta accreta and placental abruption at a higher risk. It shows that IUGR babies have a higher chance for being smaller. It also says that gestational diabetes and preeclampsia have an increased chance. So like you said, there are other things that they may have. I'm just going to throw this in there in case anyone listening is an IVF mama and wants to know more. It's interesting that you're saying that in that group– are they scheduling C-sections?Katie: Yeah. Most women get scheduled C-sections, not scheduled C-sections, scheduled inductions but they end in a C-section because they aren't ready. Meagan: Okay, so they aren't necessarily scheduling them right off the bat just because they are IVF. Katie: Right. Meagan: But again, like you said, they aren't ready and inductions are happening and people are ending up in a Cesarean. Katie: Yes. Meagan: Interesting. Well, this article was written in 2021. I'm also going to put a couple others in here that says actually 2024 so I need to look more into this but it's something to consider because again, this is a space where we are trying to reduce unnecessary Cesareans. We're seeing that it's happening so it might be something that you want to research if you are out there and you are doing IVF, research that and see if it's something that really is necessary for sure. Katie: This is just my personal story, but my placenta looked perfectly fine at 40+5 with this baby. Meagan: Yeah, so everything was looking good at that point. We did talk about that in the beginning– sticky placenta or really retained placenta. Did you have that with this? Maybe you can talk to us more about the placenta. You gave birth to babe. It was a VBAC that was a lot faster than anticipated and you went unmedicated when you didn't think you could. I kind of love that so much that you were like, “I have a low pain tolerance,” but then you did that. It just goes to show how possible it is, right? But yeah, talk to us about your placenta. Katie: Yeah. That was actually worse than the pain of the entire birth and something I didn't expect because I had asked about this because it can be an issue with IVF pregnancies. I had asked about this in one of my prenatal appointments and the midwife said, “We don't know if you're going to have that or not. IVF is a risk factor for it,” but since I had the opposite of a sticky placenta. I had a placenta that was coming off the wall. With my last pregnancy, she was like, “I'm guessing that you're not going to have that,” but I did. After baby was out, my placenta was not coming out after 10 minutes and around 30 minutes, I think they like to have it out by then. So they gave it 10 minutes for it to come out naturally, but my contractions completely stopped. Nothing was happening at that point. My body wasn't expelling it. They were trying to pull on it. Eventually, it came out but I was still having bleeding when they were pressing on my stomach than they would like to see. They gave me the Pitocin and that didn't work and then they tried two or three other medications. Meagan: Did they give you Cytotec at all? Katie: Yeah, I think so and another medication that goes in the back in the booty. Meagan: Oh, yes. They usually will insert it rectally. Yes. Yes. Cytotec is not okay when we are pregnant and we are trying to go into labor, but because it makes the uterus contract so hard which is the whole issue with Cytotec and VBAC, it can help reduce bleeding and help the placenta and all of these things. Yeah. Katie: Yeah. They gave me the max dose of Pitocin in my IV and none of that worked. They gave me the Pitocin in the leg and that didn't work, the Cytotec. Then they brought out the ultrasound machine and scanned around and saw that there were some pieces left inside. So she had to stick her hand up and get them. That was horrible. Meagan: And you were unmedicated. I'm just going to tell you right now that you have a high pain tolerance. I think you might be incorrect on that. Not saying that really, but holy cow. Unmedicated and a retained placenta retrieval scrape– they are essentially scraping and fishing for your placenta. Katie: Yes and she had to go in two or three times. They gave me some kind of IV medication and all it did was make me feel drunk. Meagan: Probably fentanyl. Katie: It was something with a D maybe. Dimerol.Meagan: Dilaudid. Katie: Maybe Dilaudid. It made me feel loopy and nauseous but did nothing for the pain. I was holding my baby the whole time and I just want to forget that horrible experience. Meagan: That is rough. Sometimes placentas “stay sticky” and it really can take up to an hour even for a placenta to come out. Sometimes we don't know why and like you said, IVF stuff maybe could have helped but the placenta usually is in that 5 to 30-minute period and providers do start to worry if it's more than that because after we have our baby, our cervix was 10 centimters. It dilated and everything was open and thinned and then it starts coming back and closing again which is the normal process. Katie: Oh my gosh. I didn't even think of that. Meagan: Yeah, it's just that normal process where it starts closing so providers start fearing that if the cervix is closed or too small, the placenta can't move through and then we've got the placenta inside and retained placenta is a very serious thing. You want to get your placenta out. It's an amazing organ and functions amazingly. It raises these amazing babies through these 9 months. It supports them and feeds them but we need to get it out because retained placenta can make you very sick. They start fearing that and sometimes when they are tugging, it can make it so the blood vessels get ripped off or they weren't ready so then we have bleeding and retained placenta and all of these things. They start fearing it and things like breastfeeding, Pitocin, Cytotec, and all of these things that they are trying to get to help you contract more is an effort to help get that out. But yeah. That is a lot. That's a lot. You had this beautiful birth and then whoa, quite a lot right there. Katie: Yeah, a bit of a turn and in addition to that, I had a second-degree tear that they also had to stitch me up. I don't remember if that was before or after the whole extraction. Meagan: Your provider fishing could have caused more tearing. Yeah. There is also a possibility that if for some reason it doesn't come out that you will have to be taken to an OR which is a more rare circumstance but I've had one client in all the 10 years of doing this and she was a VBAC client too actually. She had a beautiful birth and then had to go in and get it manually removed. So yeah, breastfeeding as soon as you can, changing positions and also emptying your bladder is something that you can do because if your bladder is full then it can hold things up so sometimes it's detached but not coming out so there are things we can do and then of course, taking medication and going a step further if we really need to. Katie: Yeah. Overall though, I don't regret any of that. It was still such a beautiful birth even though the end and the golden hour took a turn, it still was more than I had imagined. Meagan: Yeah. I was actually going to ask you. Even with that which is a lot, would you still suggest doing it or would you have done it differently if you could go back?Katie: No regrets. The recovery was a million times easier even with the tear and all of that. I was going to the botanical garden 4 days postpartum with my family. Meagan: Oh my gosh. You were out walking around. Katie: Yeah. Meagan: Oh my gosh. That is amazing. That is amazing. Katie: With toddlers, you've got to get back to real life. Meagan: I know. It's so hard to take that break and recover when we have life that is still moving around us. Katie: Definitely. Meagan: Remind me, you said you took Needed's collagen, right? Katie: I did. Yeah. Meagan: That actually probably helped healing as well. Katie: Yeah. I love that stuff because I wanted to get more protein in. I just put it in my shakes along with all of the other things that I did like the chiropractor and the dates. I did all of the things. Meagan: Yes. And your doulas, do you want to do a shoutout? Katie: Yeah, 3-1-2 doulas and I worked with Heather. Meagan: Awesome. Katie: Yeah, and they have awesome classes too. If you are a doula customer, they are free and if you're not, you can still sign up for them and they are super great. Meagan: That is so awesome. We love our doulas and to all of those listeners out there, just a reminder. We have a major doula directory from literally all over the US to outside of the US if you are looking for doulas too. You can go to thevbaclink.com/findadoula. We love our doulas so dang much. Obviously, I love doulas so much I became one. Doulas are so amazing. I love that you said you did chiropractic care and dates and all of the things. Are there any other suggestions or tips that you would give our listeners as they are going through their VBAC journey? Katie: Yeah, just listen to these podcasts a lot and you'll learn so much. Join The VBAC Link group on Facebook. Meagan: Yes. I love that community. Isn't it just amazing? Katie: Yeah, it's great. There's also another VBAC Facebook group that I loved as well. Meagan: Do you remember the name?Katie: I don't remember. Meagan: There are a few on there. We love– Katie: VBAC Support Group. Yeah, that one's great. Meagan: Awesome. Katie: Yeah, just believe in yourself. You can do it. You are a badass. Meagan: You are a badass and you can do it. I agree. We'll end on that note because that is such a true statement. Girl, you are amazing and I'm so grateful for you sharing these beautiful stories today. Katie: Thank you so much for having me.ClosingWould you like to be a guest on the podcast? Tell us about your experience at thevbaclink.com/share. For more information on all things VBAC including online and in-person VBAC classes, The VBAC Link blog, and Meagan's bio, head over to thevbaclink.com. Congratulations on starting your journey of learning and discovery with The VBAC Link.Support this podcast at — https://redcircle.com/the-vbac-link/donationsAdvertising Inquiries: https://redcircle.com/brands