Podcasts about Actin

Make sure to check the rest of the description for all of our social media links, including our Patreon (patreon.com/DoNotRelent)!  Slidewhistle, Immunization, and Aaron have been playin', slayin', and now they're SAYIN' some stuff you wanna hear. Season of Discovery is DEAD, the dinar system is BUSTED, and folks on the Proudmoore server are ACTIN' OUT! There're a lot of gags in this one, so keep those ears ready and open. Please send all your love mail, hate mail, and a better tasting Blake's Hard Cider (they're all mid to me...) to @DoNotRelentPod (Twitter) or on gmail at DoNotRelentPod@gmail.com! We will respond to literally anything and read it on the pod. Find us at: Patreon: patreon.com/DoNotRelent Linktree: donotrelent.com YouTube: @donotrelent on YouTube (the link is long and ugly) Instagram: www.instagram.com/donotrelent Twitter: twitter.com/DoNotRelentPod Livejournal: donotrelentpod.livejournal.com E-Mail: DoNotRelentPod@gmail.com Finally, if you feel so inclined, please rate us on iTunes and bonusroll.gg. We will take a shot on air in your honor! Every rating helps! :D

#TommyRichman #SexyyRed #ACTINUP #RapSeason 11 BEGINS! For Let's Talk About It: MUSIX REVIEWS. The Music Critic is gearing up ready to deliver a action packed season. Daily episodes are fully back! This SEASON is the first yearly long season! Get ready for the wild RIDE OF S11! Fun Pop Reviews, Rap Reviews AND MORE! ,actin up lyrics tommy richman,actin up tommy richman,actin up tommy richman lyrics,bend it over break it down back it up tommy richman,lyrics actin up tommy richman,million dollar baby tommy richman,richman tommy,tommy richman,tommy richman 2025,tommy richman act up,tommy richman actin up,tommy richman actin up lyrics,tommy richman music,tommy richman official video,tommy richman sexyy red,tommy richman sexyy red actin up,tommy richman song,tommy richmann

We welcomed Rufus Sims back into the lounge space to catch up & find out all about his latest release, Ill Dirty Rufus, produced by Master-ILL.It's a dope record that should mos def be added to your library.Ill Dirty Rufus is streaming now on Spotify.The next single, Actin' Crazy (featuring Bizarre), is streaming on YouTube.

#TommyRichman #ACTINUP #Rap Season 11 BEGINS! For Let's Talk About It: MUSIX REVIEWS. The Music Critic is gearing up ready to deliver a action packed season. Daily episodes are fully back! This SEASON is the first yearly long season! Get ready for the wild RIDE OF S11! Fun Pop Reviews, Rap Reviews AND MORE! ,actin up tommy richman,blue nova tommy richman,tommy richman,tommy richman actin up,tommy richman actin up instrumental,tommy richman actin up pt 2,tommy richman actin up type beat,tommy richman music,tommy richman new snippet,tommy richman new song,tommy richman official audio,tommy richman official video,tommy richman soulja boy,tommy richman soulja boy actin up,tommy richman soulja boy type beat,tommy richman tiktok song,tommy richmann

News For The Run: Coaching changes in the NFL! Jimmy Butler has been suspended indefinitely by the Miami Heat for walking out of a team shoot-around after learning he will no longer be a starter for the team. Jimmy Butler has made it VERY obvious he wants a trade but his actions lately have been extremely questionable... -- Voicemail call in: (219) 413-9405 Instagram: @TheRunPodcast  Facebook: PodcastTheRun YouTube: The Run with Manny Wilson TheRunUSA.com -- Use the Promo Code: THERUNPODCAST for $20 OFF your first ticket purchase with SeatGeek. https://seatgeek.onelink.me/RrnK/teamseatgeek   Learn more about your ad choices. Visit megaphone.fm/adchoices

Join Casie Ludemann in this lively and unfiltered spin-off of The A-Life, where she shares her candid thoughts and musings in bite-sized 5-6 minute episodes. Recorded from her kitchen while her adorable pup Remy snoozes away, these quick hits cover everything from New Year's resolutions to the ups and downs of everyday life.In each episode, Casie dives into practical tips for achieving your goals, reflecting on the importance of intention, and breaking down the barriers that hold you back. With a blend of humor and tough love, she reminds you that perfection isn't the goal—progress is. Expect to laugh, relate, and get inspired as she challenges you to embrace small changes for a better you.Don't miss out—subscribe to The A-Life: Rants & Reflections and tune in for your weekly dose of motivation that fits into your busy life. Need some accountability? Share your resolutions and join the amazing community on Facebook for extra support and fun challenges!Let's keep it real, tackle the chaos of life, and make those resolutions stick—one rant at a time!

Follow me for more content on these platforms! Twitter- https://twitter.com/Insideforwalls

Hear comedian Jim Gossett on Rob Carson's National Talk Show 12-3 on WMLB 1690 AM in ATL

Irish singer CMAT has been taking the world by storm. Shortlisted for the Mercury Music Prize and counting Elton John as a fan, her country-twinged songs capture heartbreak with a healthy dose of humour.A couple of albums in, and an Australian visit on the way, I thought it was high time we got to know the woman from Ireland, born Ciara Mary-Alice Thompson. After listening to this, you'll want to be her bestie. With an extraordinary music knowledge and plenty of craic, dive into CMAT's suckerpunch songs.Dory Previn - 'The Lady With The Braid'Belle and Sebastian – 'Expectations'Gary Stewart – 'She's Actin' Single (I'm Drinkin' Doubles)'Car Seat Headrest – 'Maud Gone'Brenda & The Big Dudes – 'Weekend Special'

Want longer episodes that cover all things human body and medicine?Join us on our other podcast!Apple PodcastSpotifyYouTube Hosted on Acast. See acast.com/privacy for more information.

UPDATE - NEW FACEBOOK PAGE - facebook.com/CountryMile24 - please do 'like' and share. PLAYLIST: George Dearborne - Misery Loves Country The Golden Roses - Slave To The Bottle William Michael Morgan - She's Actin' Single [ I'm Drinkin' Doubles ] Randy Rogers & Wade Bowen - You Got What You Wanted Randall King - I Could Be That Rain Chris LeDoux - This Cowboy's Hat Byron Hill - Younger Brand New Box Of Matches - The Devil's Gonna Getcha Twitty & Lynn - Hillbilly Git Down Brinley Addington - Darlene Megan Moroney - Heaven By Noon India Ramey - She Ain't Never Coming Home George Ducas - Mr Guitar Man Carly Pearce - truck on fire THE HOME OF TENNESSEE QUIZKEY - three questions every week! [ UK shows start from Monday: 4pm madwaspradio.com | 7pm cmrnashville.com | 7pm soundscountry.co.uk | Thursday 6pm lcruk.uk ] Sent to over 100 stations every week!

Host: Allan NewsomeRunning time: 0:43:21 Andy Saves Barney’s Morale was the 16th episode filmed and the 20th aired of The Andy Griffith Show. (S1.E20) Plot Summary Andy Saves Barney’s Morale: When Andy is called out of town, Barney gets his first chance as Actin’ Sheriff of Mayberry and jails twenty citizens, including the bank president, […]

We are talkin about the Greatest College Basketball Teams of all time. We are going from region to region (South , North , East , West). We'll let u know who's the best when we get thru

The Nintendo Drive got a new coat of paint! We're very excited about it! NEW FRIENDS! NEW ART! NEW MERCH! CAPITAL LETTERS! EXCLAMATIONS! ★ LINKS ★ ► Support Carpool Gaming on Patreon: https://patreon.com/carpoolgaming ► Join our amazing Discord community: https://discord.com/invite/WR3qcXJq9n ► Get your Carpool Gaming merch: https://carpoolgaming.com/ ► Check us out on Twitch: https://twitch.tv/carpoolgaminglive ► Subscribe on YouTube: https://youtube.com/carpoolgaming ► Follow on Twitter: https://twitter.com/carpoolgaming Thanks so much to everyone who supports us on https://patreon.com/carpoolgaming ★ ULTIMATE PRODUCERS ★ Tony Baker: https://youtube.com/quest4pixels Johnathan Brown: https://linktr.ee/pme.jib Lee Navarro: https://www.phoenixoverdrive.com/ Cwagmire: Who reminds you that the best babes are Xenobabes. ★ PLATINUM PRODUCERS ★ Robby Bobby Miller Jonas Young ★ GOLD MEMBERS ★ Adam K Anna AwesomeDave1337 BobLoblaw Bowsah Brad Moore Brian Reese Cecily Carrozza Dan & Luma Dannohh Emily O'Kelley Jon32 KC Marcus O'Neill Peje EP Tim Aulph

This Morning's Baking Ingredients The Big Bad Jada Pinkett and the threat of the liberated womanThe Crown Act ain't Actin!The Paul Robeson Negro of the Week NomineeBurning Question for the Roach; What is the solution to pushback to the Crown Act?Join the conversation Tuesday & Thursday, at 8 am-ish on Instagram Live, YouTube, and Twitter. Follow us on Instagram @WakeNBakeWithBeMo! Learn more about the host of Wake N Bake With BeMo on BeMoauthentic.com. The Wake N Bake With BeMo Podcast is proudly presented by the Bridge Podcast Network. For more information about the Washington Informer and The Bridge visit WIBridgeDC.comCheck Out Odd Mojo's SPACE Video.This week's Jam of the Week is brought to us by Detroit Rivers' Black Boy JoyIf you are interested in being a sponsor for Wake N Bake with BeMo, visit our insights page and shoot us an email.

Back pain is a common health condition affecting millions of people worldwide, decreasing their quality of life and productivity. Traditional treatments often provide temporary relief, prompting the search for innovative therapies. Peptide therapies have shown promising results in addressing back pain.  In this podcast, we'll talk about the common causes of back pain, traditional treatments used to treat back pain, and peptide therapies used for back pain management. What causes back pain? If you've had lower back pain, you know how debilitating it can be (e.g., affecting your quality of life and making it hard to work, exercise, or partake in extracurricular activities). Often, the exact cause of pain isn't understood, but most cases of low back pain come on suddenly and go away within one month. Typically, the pain comes from the spine or the ligaments and muscles around the spine. This is common in those with muscle strains or sprains of the muscles or ligaments around the spine from mild trauma or repetitive physical activity.  People who have serious medical conditions can also experience back pain. A few common causes could be arthritis of the spine (spondylosis), herniated disc (bulging disc), spinal stenosis (when the space around the spinal cord narrows, causing pain, numbness, or tingling in the legs. How can I make my back pain stop? If your back is bothering you, there are some treatments that you can try at home to help lessen the pain. Non-strenuous activity:  Although you're in pain and you may want to stay in bed when you have back pain, it's important to know that this can make the pain worse. It helps to try activities like walking and gentle stretching. Over-the-counter (OTC) medications: You might be able to help relieve acute back pain with OTC anti-inflammatory medications like naproxen or ibuprofen. These medications block the body's production of prostaglandins (natural chemicals) that trigger pain, swelling, and inflammation. Heat or ice: It's hard to know when to use heat vs. ice for back pain. The rule of thumb is to start with ice when your back hurts after a minor injury. You can use ice packs, cold towels, and ice baths. You can try this for 2 days and then move to heat. Heat helps with pain by increasing blood flow to help relax your muscles and help the body to repair injured tissue. Heat will not only help with pain but can also help with stiffness to loosen up your back muscles. This, in turn, helps with your mobility to get you back to living a normal life. For heat, you can apply hot water bottles to the area of pain. You can also use hot towels, heating pads, and saunas.  If you have back pain that lasts more than one month or occurs with symptoms like severe numbness or weakness in the legs, inability to urinate, or numbness in the groin, talk to a healthcare provider. Never try to treat back pain at home if your pain is caused by a major trauma or injury (e.g., car accident or fall) or a previous spinal procedure (e.g., surgery or injections). Peptides for back pain BPC-157- BPC 157, or Body Protection Compound 157, is a peptide derived from stomach acid. It works by decreasing inflammation and increasing blood flow to damaged tissues. It speeds up the healing of wounds, tendons, ligaments, bone injuries, your nervous system, and even the digestive tract.  LL-37- LL-37, a naturally occurring antimicrobial peptide, exhibits potent anti-inflammatory properties. Chronic back pain often results from inflammation of spinal nerves and surrounding tissues. LL-37 mitigates inflammation, providing relief to patients suffering from conditions like sciatica and herniated discs. By modulating the immune response, LL-37 promotes healing and reduces pain. Thymosin Beta-4 (TB4)-  Thymosin Beta-4 is a peptide used for cellular regeneration. It plays a pivotal role in tissue repair and wound healing. In the context of back pain, TB4 aids in regenerating damaged spinal discs and muscles, offering long-term relief.  It works by binding actin (proteins that make up 10% of the total proteins in cells). Actin helps with cell division, signaling, and shape. It also speeds up the rate of new tissue growth and new blood vessel formation. TB4 also helps wounds heal. Melanocortin Peptides- Melanocortin peptides, including Melanotan II, have shown promise in managing chronic pain conditions. These peptides work by modulating the body's pain perception pathways, providing relief to individuals suffering from persistent back pain. By interacting with melanocortin receptors, these peptides alter neurotransmitter levels, effectively reducing pain signals transmitted to the brain. Substance P Inhibitors- Substance P is a neurotransmitter associated with pain perception. Peptide therapies targeting Substance P receptors can effectively alleviate back pain by inhibiting nerve sensitivity. By blocking these receptors, these peptides reduce the transmission of pain signals, offering relief to patients with conditions like neuropathic back pain. Peptide therapies represent a groundbreaking approach to back pain management, offering hope to individuals whose lives are hindered by chronic discomfort. As research in this field continues to advance, peptide therapies are set to revolutionize the way we treat back pain, providing a brighter future for millions who suffer from back pain.  Note: Always consult with a healthcare professional before undergoing any peptide therapy to ensure safe and effective treatment. Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! Pro Tips We're huge advocates of using daily greens in your routine to help with gut, skin, nail, bone, and joint health. We take AG1 (athletic greens) every day. Not only does it have vitamins, minerals, and a diverse range of whole-food sourced ingredients, but it also has probiotics to promote a healthy gut microbiome and adaptogens to help with focus and mood balance. It's vegan, paleo, and keto-friendly.  

Ladies (& our 3% of listeners that are gentlemen)...is this the antibiotics from Dani's recent hospital visit talking, or is our favorite duo just ACTIN'. UP. this week?! Tune in as D&J share laughs, shed tears, and dive deep into all the things. You'll see. ;) As mentioned, we worked out a special offer for my audience. Receive 15% off your first order. Go to tryarmra.com/DANI or enter DANI to get 15% off your first order.  Go to honeylove.com/DEINFLUENCED to treat yourself to the best bras on the market and save 20%.  Head over to dreamlandbabyco.com and enter code DANI at checkout to receive 20% off sitewide + free shipping. This offer applies to both new and existing customers. 

Just because you are a Christian does not mean that you have discovered ALL the “answers” to life's questions. We were meant to grow in our faith and knowledge of who our God is!

GET IT TOGETHER! Follow Grace across everything on they link tree! LINK HERE If you like the show, leave us a 5 Star Review ⭐️ ⭐️ ⭐️ ⭐️ ⭐️ if you didn't, go away. ;) 

Show: American MonsterEpisode: The Only Way OutRoger and Donna Harris were married for 10 years with two little boys.  Donna was a nurse and Roger was retired military.  While visiting Donna's parents for Thanksgiving in 1998, everything was thought to finally be going well. Unfortunately a few days later Roger reports Donna missing in a 911 call.  It only takes 72 hours for all to become clear. Support the showCheck out our website: https://www.buzzsprout.com/837988 Linktree: https://linktr.ee/itsalwaysthehusbandpodcast Like our Facebook page and join our group!! Instagram: @itsalwaysthehusbandpodcast Twitter: @alwaysthehubs Etsy Shop: https://www.etsy.com/shop/ItsAlwaysTheHusband?ref=simple-shop-header-name&listing_id=776055218 Theme song by Jamie "I'm Gonna Kill You, Bitch" Nelson

With the release of the seminal grunge album Nevermind, Nirvana had positioned themselves (unwillingly) into unknown territories of superstardom. As pressures increased to meet and eclipse the success of Nevermind, the band entered the studio alongside audio engineer Steve Albini with their own set of rules and the intention to create a follow up that was more reflective of the music they wanted to make. The outcome was darker, moodier, nosier, and heavier than anything that preceded it. This week on Riff Worship, Austin & Dylan are joined by their longtime friend Justin Swindle to discuss Nirvana's classic third and final album In Utero. Recommendations: Baroness - "Last Word" MSPAINT - Post-American Militarie Gun - Life Under The Gun Wormhole - "System Erase" Spirit Adrift - "Barn Burner" Fleshbound - Wounded EP Thirdface - "Trap Revealed" Pain of Truth, 200 Stab Wounds - "Actin' Up" Sector - The Chicago Sector Quiet Man - "Set to Boil Is The New Standard" For all updates on the show, follow us here: @distortion891 on ⁠⁠⁠⁠Facebook⁠⁠⁠⁠, ⁠⁠⁠⁠Instagram⁠⁠⁠⁠, & ⁠⁠⁠⁠Twitter⁠⁠⁠⁠ Tune in LIVE to Vocal Distortion, Mondays at 6PM CST on FM89, ⁠⁠⁠⁠WONC.org⁠⁠⁠⁠, & the ⁠⁠⁠⁠iHeart Radio app⁠⁠⁠⁠ RIFFS ON REPEAT PLAYLIST: ⁠⁠⁠⁠https://open.spotify.com/playlist/37W4wEyb5ELf2y0YYlhRy2?si=8529ae1e880d442c⁠

(airdate 6-20-23) @adele shares a little TMI about her fungal infection from performing on stage in Las Vegas.  @chrishemsworth met up with Arnold @Schwarzenegger in Brazil over the weekend at the gym, where else? And @HalleBerry Listen to the daily Van Camp and Morgan radio show at: AltBossGold.com 92.5TheBlock TRIK FM RockPartyRadio RiverRatRadio The Mix614 Sunny105 Souldies.com KTahoe.com RetroFM 941now.com ZFunHundred Tucka56Radio.com AmericaOneRadio.com TheMix96.com 100az.live Audacy Lite99Orlando.com PlayFMOnline.com Free99EastTexasRadio FrontierCountryOnline.com Hits247fm.com BossBossRadio.com Hot977FM.com CountryBarnyardRadio.com B98KC.com That70sChannel.com iHeartMedia Boss90sNow.com CoolJamzRadio GenerationsX.com MagicRadio.rebelmediagroup.us BossCountryRadio.com Retro80sRadio24/7 NCMCountry OasisRadio Z89.3 StarHit1FM  925The Block 247TheSound.com WMQL War Zone Radio  WRSR The Rooster DCXRocks  FusionRadio Mix96.1 106.5TrisJamz BigRadio.online 389country.com Power104  find us at: VanCampAndMorgan.com  

At the table this week, the guys discussed the following: 5:37) PSA With O'shea: "Explaining the Culture" (7:40) What is the best message to text a girl in the morning? (23:33) Are there any words or phrases you cannot pronounce? (32:42) Would you want to know if your parents were swingers? (41:28) What do you do if you match with your Boss on a dating app? Thanks for the love and support! Follow us @thebltpod on all socials! --- Send in a voice message: https://podcasters.spotify.com/pod/show/theblt/message Support this podcast: https://podcasters.spotify.com/pod/show/theblt/support

This is an episode about... Nothin'! Be sure to send in your listener letters to not4nothinpod@gmail.com or Dm us on instagram @not4nothinpod  Follow Saint on twitch. Twitch.tv/TheRealHampton Be sure to subscribe to our Youtube as we upload videos weekly! https://www.youtube.com/channel/UCJSUfR7xfNx35wZ2ITQwGeg Love you Guys!! Til next week

Is there more to laughter than you think? Let's find out…

Due to some technical difficulties, we unfortunately lost the video to this episode of the Pod, BUT we still got yaw with the classic audio! Tune in to hear the guy's discuss SPOILER WARNING GOTG V3, Jonathon Majors, Men's Self Defense, and the Writers Guild Strike! Tune in and enjoy!#marvel #jonathanMajors #hollywood #MCU #Kang #podcast #comedy #fighting #domestic #police

WHAT DO YOU DO WHEN THE SHOWS ARE SO FEW? YOU INVITE YOUR CUZZINS ON! I've got my besties here with me today (Kaya and Aaron of the “Bravo! We're Black” podcast), and the conversation was… ignorant, per usual. We talked about everything from Baddies West and Bad Boys on Zeus to our favorite daytime judges (RIP Judge Jerry Springers). Then, we jump into the very few shows airing on Bravo currently: Real Housewives of New Jersey and Vanderpump Rules. We even get to hear about the premiere of the new season of the Real Housewives of Atlanta from two black, beautiful people who have seen the screener. COME ON INFLUENCERS! Follow BWB on Instagram! Check out BWB's Podcast (on Apple Podcasts)! Check out BWB's Podcast (on Spotify)! Check out BWB's Patreon (where I'm on the latest episode)! NO SPONSORS! *** HEY! Some of you have asked how you can show your appreciation for all of the content provided by your mama's favorite Black geek. How about you buy me a beer/coffee? CLICK HERE TO SUPPORT! *** New episodes of “Reality & Comics Too” are released every Monday, Wednesday, and Thursday! DON'T FORGET TO SUBSCRIBE, RATE, AND REVIEW! I LOVE 5 STARS! EMAIL ME AT REALITYCOMICSTOO@GMAIL.COM! FOLLOW ME ON INSTAGRAM! Learn more about your ad choices. Visit megaphone.fm/adchoices

Rob and Justin are joined by a special guest as they review the latest Makoto Shinkai film, Suzume no Tojimari --- INSTAGRAM: https://www.instagram.com/sclass_yt/ TWITTER: https://twitter.com/sclass_yt EMAIL: sclasspodcast@gmail.com

Even David makes some foolish decisions! This time, God sent an incredible woman named Abigail to talk some sense into him before he did something really foolish. Are you living a life of a fool? Or maybe just making some really foolish decisions? Either way, we have someone who have stepped in on our behalf […]

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This week, with producer Ryan on a break, the boys get deep. Chris dives into a personal moment he experienced during the week and really opens up for the podcast. The fellas also cover AEW Revolution and discuss blood in wrestling matches. This week's episode features a song from the Envy Me Podcast's very own producer Ryan. Please also support him and his music by following him on all social media and streaming platforms @BGtheBoyGenius

0:00 Princess Diana 2:40 Gangsta Boo 4:02 Actin a Smoochie 6:34 Boys a Liar pt. 2 7:39 Bikini Bottom 9:20 Munch 11:22 In ha Mood All uploads on this channel are for promotional purposes only! The music has been converted before uploading to prevent ripping and to protect the artist(s) and label(s). If you don't want your content here  please contact us immediately via email: allmusiclive@outlook.com and WE WILL REMOVE THE EPISODE IMMEDIATELY! 

BRAVO... BRAVOLEBRITIES… ARE Y'ALL OK?! Once again, we're coming to you with URGENCY because the Bravolebrities have been SHOWING THEIR HIND REGIONS all week long! From California to Potomac down to Atlanta! This episode, however, we mostly had to focus on the “Tom, Ariana, and Raquel” of it all. You're in for a treat because you know I RARELY discuss Vanderpump Rules on the podcast, but BOY OH BOY am I intrigued in the madness. I called in Kaya and Aaron of the “Bravo! We're Black” podcast since VPR was one of their gateway Bravo shows. I let them take the lead on this episode so that we can truly BREAK IT ALL DOWN! Follow “Bravo! We're Black” on Instagram! Check out “Bravo! We're Black” on Apple Podcasts! Check out “Bravo! We're Black” on Spotify! Check out the “Bravo! We're Black” Patreon! SPONSOR FREE EPISODE! *** HEY! Some of you have asked how you can show your appreciation for all of the content provided by your mama's favorite Black geek. How about you buy me a beer/coffee? CLICK HERE TO SUPPORT! *** New episodes of “Reality & Comics Too” are released every Monday, Wednesday, and Thursday! DON'T FORGET TO SUBSCRIBE, RATE, AND REVIEW! I LOVE 5 STARS! EMAIL ME AT REALITYCOMICSTOO@GMAIL.COM! FOLLOW ME ON INSTAGRAM! Learn more about your ad choices. Visit megaphone.fm/adchoices

After some paperwork and mock interviews, the party moves on to the next stop of their con, The Infinite Pool.

Happy Women's History Month! We're back with a CLASSIC film, 1992's Sister Act, and we talk about A LOT in this episode, true crime, tiktok, masturbation, Catholicism and MORE! Thanks for listening! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/textured-heir/support

Cooder Graw - Whiskey Bent and Hell Bound (Hank Jr )Rance Norton - Slide Off Of Your Satin Sheets ( Johnny Paycheck )Jason Cassidy - I Think I'll Just Stay Here And Drink ( Merle Haggard )Randy Rogers Band- She's Actin' Single (I'm Drinkin' Doubles) ( Gary Stewart )Cross Canadian Ragweed - Whiskey River ( Johnny Bush - Willie Nelson )Zach Edwards - Big Balls Mix ( Bob Wills - ACDC )Bryan Deere - Too Hot To Handle ( Eddie Noack - Frankie Miller )Sammy Kershaw -  Memphis, Tennessee ( Chuck Berry )Jonas Shandel - Highway Patrol ( Red Simpson - Junior Brown )Karen Pendley - I'll Be There ( Ray Price )Deryl Dodd - Together Again ( Buck Owens )Jamey Johnson & Ronnie Dunn -  A-11 ( Johnny Paycheck )Freddy Holcomb - Lonesome 7-7203 ( Hankshaw Hawkins )Trent Summar - He Stopped Loving Her Today ( George Jones )Dwight Yoakam -  Send Me The Pillow ( Hank Locklin )Trick Pony - Big River ( Johnny Cash )Ricky Van Shelton - Working Man Blues ( Merle Haggard )Jackson Taylor & TheSinners -  Two More Bottles of Wine ( Emmylou Harris )Willie Nelson & Kenny Wayne Shepherd -  Texas Flood ( Stevie Ray Vaughn )Adam Brand & The Outlaws - Take This Job And Shove It ( Johnny Paycheck )Support this podcast at — https://redcircle.com/thehonkytonkjukebox/exclusive-content

Since catching the attention with “Munch (Feelin' U)” last August, Ice Spice has been on the very tip of many tongues.The Bronx freestyle specialist followed it up with “Bikini Bottom,” a fun exercise in drill which could easily soundtrack an silly scene from Spongebob Squarepants.“Munch” has racked up more than 25 million views on YouTube and 39 million listens on Spotify, and landing spots on the Billboard Rhythmic Airplay, Bubbling Under Hot 100 and Hot R&B/Hip-Hop Songs charts.“Bikini Bottom” is at 9.5 million and 39 million plays, respectively.Cardi B and Lil Nas X are fans, and Billboard anointed her as October R&B/Hip-Hop rookie of the month.All that love and attention spilled over when Vevo sent Ice Spice to the 2023 class of “DSCVR Artists to Watch”.The 23-year-old rapper is repaying the faith, and getting in early with Like…? (via Capitol), a new six-track EP which dropped at the stroke of midnight.The six-pack captures “Munch” and Bikini Bottom” at the back-end, with the recently-released cut “In Ha Mood,” and newbies “Princess Diana,” “Gangsta Boo” with Lil Tjay, and “Actin a Smoochie” at the top.source: Ice Spice Drops Six-Track EP ‘Like…?': Stream It Now (msn.com)Support this podcast at — https://redcircle.com/analytic-dreamz-notorious-mass-effect/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

This month on Episode 44 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the January 6th and January 20th issue of Circulation Research. This episode also features an interview with Dr Timothy McKinsey and Dr Marcello Rubino about their study, Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart.   Article highlights:   Prasad, et al. ACE2 in Gut Integrity and Diabetic Retinopathy   Cui, et al. Epsins Regulate Lipid Metabolism and Transport   Li, et al. Endothelial H2S modulates EndoMT in HF   Luo, et al. F. plautii Attenuates Arterial Stiffness   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's Journal Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh. And today I'm going to be highlighting articles from our January 6th and January 20th issues of Circulation Research. I'm also going to have a chat with Dr Timothy McKinsey and Dr Marcello Rubino about their study, Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart. But before the interview, I want to get to a few articles to highlight.   Cindy St. Hilaire:        The first article is titled, Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 Diabetes. The first authors are Ram Prasad and Jason Floyd, and the corresponding author is Maria Grant, and they are from the University of Alabama.   Type 1 Diabetes has a complex etiology and pathology that are not entirely understood. In addition to the destruction of insulin-producing cells, a recently discovered feature of the disease in both humans and in rodent models is that the levels of angiotensin converting enzyme 2 or ACE2 can be unusually low in certain tissues. ACE2 is a component of the renin angiotensin system controlling hemodynamics and interestingly, genetic deficiency of ACE2 in rodents exacerbates aspects of diabetes such as gut permeability, systemic inflammation and diabetic retinopathy, while boosting ACE2 has been shown to ameliorate diabetic retinopathy in mice. This study shows that ACE2 treatment also improves gut integrity and systemic inflammation as well as retinopathy. Six months after the onset of diabetes in a mouse model, oral doses of a bacteria engineered to express humanized ACE2 led to a reversal of the animal's gut barrier dysfunction and its retinopathy. Humans with diabetic retinopathy also displayed evidence of increased gut permeability in low levels of ACE2. This study suggests they may benefit from a similar probiotic treatment.   Cindy St. Hilaire:        The next article I want to highlight is titled, Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression. The first authors are Kui Cui, Xinlei Gao and Beibei Wang, and the corresponding authors are Hong Chen and Kaifu Chen and they're from Boston Children's Hospital. Epsins are a family of plasma membrane proteins that drive endocytosis. They're expressed at varying levels throughout the tissues of the body, and recent research shows that they are unusually abundant on macrophages within atherosclerotic lesions. In mice, macrophage specific Epsin loss results in a reduction in foam cell formation and atherosclerotic plaque development. This study now shows that this effect on foam cells is because Epsins normally promote the internalization of lipids into macrophages through their endosytic activity.   But that's not all. The proteins also impede cholesterol efflux from macrophages to further exacerbate lipid retention. It turns out out Epsins regulate the endocytosis and the degradation of a cholesterol efflux factor called ABCG1. Importantly, these pro atrogenic activities of Epsins can be stopped. Using macrophage targeted nanoparticles carrying Epson specific silencing RNA, the team could suppress reduction of the protein in cultured macrophages and could reduce the size and number of plaques in atherosclerosis prone mice. Together these results suggest blocking Epsins via nanotherapy or other means could be a therapeutic approach to stopping or slowing atherosclerotic plaque progression.   Cindy St. Hilaire:        The third article I want to highlight is coming from our January 20th issue of Circ Res and is titled, Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure. The first author is Zhen Li, and the corresponding author is David Lefer and they're from Cedars-Sinai. Hydrogen sulfide is a critical endogenous signaling molecule that exerts protective effects in the setting of heart failure. Cystathionine γ-lyase, or CSE, is one of the three hydrogen sulfide producing enzymes, and it's predominantly localized in the vascular endothelium. Genetic deletion of CSE, specifically in the endothelium, leads to reduced nitric oxide bioavailability, impaired vascular relaxation and impaired exercise capacity, while genetic over-expression of PSE in endothelial cells improves endothelial cell dysfunction, and attenuates myocardial infarction following myocardial ischemia-reperfusion injury.   In this study, endothelial cell specific CSE knockout mice and endothelial cell specific CSE overexpressing transgenic mice were subjected to transverse aortic constriction to induce heart failure with reduced ejection fraction. And the goal was to investigate the contribution of the CSE hydrogen sulfide access in heart failure. Endothelial specific CSE knockout mice exhibited increased endothelial to mesenchymal transition and reduced nitric oxide bioavailability in the myocardium. And this was associated with increased cardiac fibrosis, impaired cardiac and vascular function, and it worsened the vascular performance of these animals. In contrast, genetic overexpression of CSE in endothelial cells led to increased myocardial nitric oxide, decreased EndoMT and decreased cardiac fibrosis. It also improved exercise capacity. These data demonstrate that endothelial CSE modulates endothelial mesenchymal transition and ameliorated the severity of pressure overload induced heart failure , in part through nitric oxide related mechanisms. This data further suggests that endothelium derived hydrogen sulfide is a potential therapeutic for the treatment of heart failure with reduced ejection fraction.   Cindy St. Hilaire         The last article I want to highlight is titled, Flavonifractor plautii Protects Against Elevated Arterial Stiffness. The first authors are Shiyun Luo and Yawen Zhao, and the corresponding author is Min Xia, and they are at Sun Yat-sen University. Dysbiosis of gut microbiota contributes to vascular dysfunction and gut microbial diversity has been reported to be inversely correlated with arterial stiffness. However, the causal role of gut microbiota in the progression of arterial stiffness and the specific species along with the molecular mechanisms underlying this change remain largely unknown. In this study, the microbial composition in metabolic capacities were compared in participants with elevated arterial stiffness and in normal controls free of medication. And these groups were age and sex match.   Human fecal metagenomic sequencing identified a significant presence of Flavonifractor plautii or F. plautii in normal controls, which was absent in the subjects with elevated arterial stiffness. The microbiome of normal controls exhibited an enhanced capacity for glycolysis and polysaccharide degradation, whereas individuals with increased arterial stiffness exhibited increased biosynthesis of fatty acids and aromatic amino acids. Additionally, experiments in the angiotensin II induced and humanized mouse model show that replenishment with F. plautii or its main effector cis-aconitic acid or CCA improved elastic fiber network and reversed increased pulse wave velocity through the suppression of matrix metalloproteinase-2 and through the inhibition of monocyte chemoattractant protein-1. And this was seen in both the angiotensin II induced and humanized models of arterial stiffness. This study now identifies a novel link between F. plautii and arterial function and raises the possibility of sustaining vascular health by targeting the gut microbiota.   Cindy St. Hilaire:        Today with me I have Dr Tim McKinsey and Dr Marcello Rubino from the University of Colorado Anschutz Medical Campus, and we're here to talk about their paper Inhibition of Eicosanoid Degradati`on Mitigates Fibrosis of the Heart. And this article is in our January 6th issue of Circulation Research, so thank you both so much for joining me today.   Timothy McKinsey:    Thank you for inviting us.   Marcello Rubino:        Yeah, thank you for the opportunity.   Cindy St. Hilaire:        And so Dr McKinsey, you're a professor at the University of Colorado. How long have you been investigating cardiac fibrosis?   Timothy McKinsey:    Oh, a long time. Before I started the lab here in 2010, I was in industry working in biotech with Myogenic Gilead, and we were very interested in cardiac fibrosis all the way back then.   Cindy St. Hilaire:        Oh wow, so you actually made an industry to academia transfer.   Timothy McKinsey:    Yes.   Cindy St. Hilaire:        Good topic for another podcast. That is really great.   Timothy McKinsey:    Yeah, it's of interest to a lot of people, including trainees.   Cindy St. Hilaire:        Yeah, I bet. Dr Rubino, you were or are a postdoc in the McKinsey lab? Marcello Rubino:        Yeah, I was a postdoc in Timothy McKinsey lab. I spent four years in Tim's lab. It was my first time studying cardio fibrosis, so it was a little bit difficult at the end, but I think I was right choosing Tim, so I'm really happy now.   Cindy St. Hilaire:        Nice and are you sticking with fibrosis or are you moving on?   Marcello Rubino:        Yeah, so now I'm back in Milan where I did my PhD student and postdoc. I am like an independent researcher, but it's still not a principal investigator, so I want to become one of the that, studying cardiac fibrosis. Yeah. And inflammation and epigenetics, so yeah, I'm going try to go to my way, thanks to Tim, I think that I find my own way.   Cindy St. Hilaire:        I'm sure you will. I mean, based on the great work in this study, right. Building upon that, I'm sure you'll be a success.   Timothy McKinsey:    No doubt about it.   Cindy St. Hilaire:        So your manuscript, this study, it's investigating whether eicosanoid availability can attenuate fibrosis in the heart. But before we kind of jump into this study, why is fibrosis in the heart a bad thing? Is it always detrimental? Is there some level of fibrosis that's necessary or even helpful?   Timothy McKinsey:    I mean, a certain level of extracellular matrix is deposited in your heart and that maintains the structure of the heart. Fibrosis can also be good after you have a myocardial infarction and a big piece of the muscle of your heart has died, it needs to be replaced with a fibrotic scar, essentially to prevent rupture of the ventricle. So fibrosis isn't always bad, but chronic fibrosis can be really deleterious to the heart and contribute to stiffening of the heart and cause diastolic dysfunction. It can create substrates for arrhythmias and sudden cardiac death. So we're really trying to block the maladaptive fibrosis that occurs in response to chronic stress.   Cindy St. Hilaire:        Yeah, yeah. And what about eicosanoids? What are they and what role do they play in cardiac fibrosis or what was known about their role in this process before your study?   Timothy McKinsey:    Eicosanoids are lipids, they're basically fatty acids, 20 carbon in length and a lot is known about them. It's a very complex system. There are many different eicosanoids, but they're produced from arachidonic acid through the action of cyclooxygenase enzymes like COX-2. And so you're probably familiar with the literature showing that non-steroidal anti-inflammatory drugs that target the COX enzymes can actually increase the risk of cardiac disease, so there was a lot known about what produces eicosanoids in the heart, but our study is really the first to address how they're degraded and how that controls cardiac fibrosis.   Cindy St. Hilaire:        What I thought you did really well in the introduction and what I guess I didn't really fully appreciate until I had read your study, was that your goal was to identify compounds that could attenuate fibrosis. And you spent some time emphasizing the differences between a targeted small molecule screen and a phenotype based screen. And I was wondering if you could just expand on this difference for the audience and maybe just explain why in your case you went with the latter.   Timothy McKinsey:    Well, we wanted to use an unbiased approach and some people call this a chemical biology approach where we took a targeted library, meaning we took compounds with known activities, meaning compounds that with known targets and we screened that library using a phenotypic assays that we developed in the lab. And the phenotypic assay is an unbiased assay, right? We're just screening for compounds that have the ability to block the activation of fibroblasts. And we monitor activation by looking at markers of fibroblast activation such as alpha smooth muscle Actin. And we can do this in a very quantitative and high throughput manner using this imaging system, high content imaging system that we have in the lab.   It was an unbiased screen looking for inhibitors of fibroblasts activation across organ systems. We not only studied cardiac fibroblasts, but we also studied lung and renal fibroblasts looking for compounds with a common ability to block the activation state of each of those cell types.   One of the things that I get asked frequently is how do we maintain the cardiac fibroblasts in a quiescent state? Because you may know this, but when fibroblasts are plated on cell culture plastic, which has a very high 10 cell strength, they tend to spontaneously activate, so we actually spent a couple of years working out the conditions to maintain the cells in quiescent state, and I think that will also be of great interest to the field.   Cindy St. Hilaire:        Probably even the smooth muscle cell biology field where I hang out and even valve interstitial cells that we study. All of those, I guess basic things related to cell culture, we have taken for granted that plastic is not physiological.   Timothy McKinsey:    Right.   Cindy St. Hilaire:        And so I think with this really nice phenotypic or chemical screen that you conducted, you first identified nine compounds, but what made you zero in on this one, SW033291?   Timothy McKinsey:    When we got the hits, we were intrigued by the SW compound SW033291 because there was only one paper describing its action and there was a paper published in Science showing that SW or inhibition of this enzyme 15-PGDH could enhance organ regeneration.   Cindy St. Hilaire:        Oh, okay.   Timothy McKinsey:    And there's a very interesting interplay between fibrosis and organ regeneration where fibrosis inhibits regeneration and if you can stimulate regenerative pathways, they can actually block fibrosis, so there's this back and forth. And so that's really the main reason we were interested in pursuing SW just because of the novelty and the potential. And also it was a compound that behaved beautifully in our cell culture models with beautiful dose-dependent inhibition of each of the fibroblast types.   Cindy St. Hilaire:        It's kind of like the cleanest thing to start with. Also, if there's nothing known, it's ripe for investigation, so that's great. You just said this SW compound acts on 15-PGDH, so what is the role of that protein in fibroblasts and what if any known effects are there on this protein's inhibition in other cell types or disease states?   Marcello Rubino:        In fibroblasts team, I would like to say that this was really the first article that was published. Maybe there was just one published in Pulmonary Fibrosis, but like last year, but I didn't really talk about 15-PGDH, so you need to consider that 15-PGDH is an inhibitor, an enzyme that degrades prostaglandin, so if you inhibit the inhibitor, the release increase production, a lot of prostaglandin. And so a lot of paper were talking about this effect, so they will see we are just using SW in order to increase Prostaglandin E2 level and that was why we had this like anti-inflammatory or whatever effect. I would like to say that until now, maybe this can be the first really paper talking about no more than not just prostaglandin but 15-PGDH. Its action total level, a global level at particularly on fibroblasts.   To answer your question, I would like to say that this was also our question first and we checked by level other browser to try to find the answer to your question. We figured out that it was known that 15-PGDH was increasing a pathology condition in different organ, not just related by fibroblasts, not just related to cardiac disease, about the function with discover a function in macrophage that interested us because it can regulate maybe the polarization macrophage, so still involving the prostaglandin production inflammation, so that's why also we decide to take a look because it was still novel in fibrolbasts and we still know that it was doing something important and we were trying not to put the piece together and find something new in that we were lucky for this.   Timothy McKinsey:    15-PGDH is actually expressed at very low levels in fibroblasts. It's much more highly expressed in macrophage, just as Marcello pointed out, so in the future we're very interested in knocking out or inhibiting 15-PGDH in different cell types to see how that contributes to inhibition of cardiac fibrosis.   Cindy St. Hilaire:        Really interesting. Related to that, you used a couple different animal models for fibrosis. They're all different or special in their own way. How well did these recapitulate what we observe in humans. Are there any limitations of benefits?   Timothy McKinsey:    They're always limitations to animal models. We started out with a very robust commonly used model of cardiac fibrosis, which relies on Angiotensin II infusion in mice. We like that model because it's robust and quick so we can get answers quickly. And then we transitioned into a model of diastolic dysfunction that we've been working with in a lab where we remove a kidney from a mouse and we implant something called DOCA, which is an aldosterone memetic. And so the animals develop hypertension that leads to a mild but significant diastolic dysfunction with preserved ejection fraction.   And that's a model that we like a lot. It has something that we call hidden fibrosis, so if you just do standard histochemical staining of the hearts from the DOCA unit, nephrectomy model, that diastolic dysfunction model, you really can't see robust fibrosis. It's only when you dive more deeply with more sensitive assays like mass spectrometry or atomic force microscopy that you can detect this fibrosis and stiffening of the heart, so we usually lead with a robust model of fibrosis, cardiac fibrosis, and then transition into a slightly more complex model but more physiologically relevant model or disease relevant model.   Cindy St. Hilaire:        Obviously you showed some really nice robust results with this SW compound. So in the continuum of heart failure in human, what do you think or what would you speculate would be the ideal timeframe for administration of this compound?   Timothy McKinsey:    Wouldn't want to give it immediately after someone's had a heart attack. As we discussed earlier, you need that reparative scar to form so you don't want to block that fibrotic remodeling. We believe that there's kind of smoldering fibroblast activation in the heart, even in someone who's had heart disease for many, many years. And if we can dampen that, we can either prevent further progression of heart failure or perhaps reverse it. We don't really know if we can reverse really established fibrosis in the heart yet. But I would want to try to catch fibrosis fairly early on in the disease process in someone who has chronic hypertension or obesity or a variety of different comorbidities and then start delivering an antifibrotic therapy at that point.   Marcello Rubino:        I would like to add that, so it is really tricky when we talk about clinical trials because a lot of molecules that maybe they can work hopefully in a preclinical model don't work at the end in the clinical model. That's because can be some off target also like you just asked what is really important is when you do the administration of the molecule and talk about this in SW, like things say we don't want to prevent the fibrosis because there is something like called a kneeling at the beginning, so it is the good fibrosis we like to say, but the good thing of SW compound is that is affecting in a good way the proliferation of fibroblast that is different for all the other. I would like to say all the other inhibitor that we saw so far, because I remember the first time that I presented this work, there was an expert told me that he didn't believe that all my data because the compound was inhibiting fibrosis, it was inhibiting proliferation.   And I show him, no, this is contrary, so oh okay, I like it. We need to consider this that the action seems to be not like the retire for the cell, so because the cells continue to proliferate, they can proliferate more. But the good thing and we need to investigate more is that SW action seems to increase when the cell are more fibrotic, because we show just few human fibroblasts isolating from a human patient and we saw a higher positive effect of SW compound when the cell were more fibrotic. That can be interesting. I think that it's worth to try to test in the future like in different preclinical models and maybe in patients at the end because if we really can find something like maybe SW that can be specific for the state of pathology, that will be wonderful. I don't really know if we can really do it, but we need some therapy like this, so that's why we were really excited about what we discovered for this compound.   Timothy McKinsey:    We have a lot more to learn about this pathway and about fibrosis in general.   Cindy St. Hilaire:        Yeah.   Timothy McKinsey:    It's a very exciting time to be doing science because of the amazing technologies that we have at our disposal to address detailed mechanisms of disease.   Cindy St. Hilaire:        What was the most challenging aspect of the study?   Timothy McKinsey:    This was an incredibly difficult study. I can't even stress to you how much work went into this. Spearheaded by Marcello's awesome leadership. There was huge input from a big team. Keith Cook and I worked together in industry and we were able to recruit him over here for a few years as part of our fibrosis center called the CFReT. It's an advertisement. And Keith was able to implement some of the drug discovery approaches that we used in biotech and create this imaging system that we initially employed for the screens. That was challenging. Maintaining the cells in a quiescent state was very challenging as I mentioned. That took a couple of years and then just following up on SW and trying to figure out its mechanism of action was really challenging as well because as Marcello mentioned, most people have attributed SW's effects to an increase in PGE2 levels, so PGE2 is an eicosanoid that is degraded by 15-PGDH.   And definitely when you inhibit 15-PGDH with SW, you see increased PGE2. But surprisingly we couldn't find that PGE2 was doing anything in our cell culture systems, meaning when we added it exogenously it was not blocking fibroblast activation, so then Marcello set out to identify which eicosanoid that is regulated by 15-PGDH is actually the antifibrotic eicosanoid. And that led him to something called 12(S)-HETE. That was challenging. And then just determining at the molecular level what was going on was also challenging. And that led Marcello to this kind of paradoxical discovery that it activating ERK signaling was actually blocking fibroblast activation.   Cindy St. Hilaire:        And of course ERK does everything right?   Marcello Rubino:        It does. Everything.   Timothy McKinsey:    And sort of the dogma is that ERK is promoting fibrosis in the heart, but Marcello's data suggests otherwise.   Timothy McKinsey:    And then other shout outs, Josh Travers, who's the second author of the paper provided huge input, especially after Marcello left. Josh helped get this across the finish line. We have an amazing in vivo team conducting the animal model studies. Maria Cavasin and Elizabeth Hardy. I could go on and on. There are a lot of authors and if I didn't mention one of them, it doesn't mean that they weren't key contributors. I just wanted to throw that out there. We also had great collaborators. I think another component of this paper that is of great interest to us, and initially I was against doing any of this, is that Marcello and Josh created this biobank of human cardiac fibroblasts that we obtained from explanted hearts from individuals undergoing heart transplantation.   And initially I thought it was going to be a waste of time and money for Marcello and Josh to do that, but they were persistent and they started isolating these cells. And the cells are really fascinating because even after you take them out of that failed human heart and culture them, they maintain this constituently active state, which is different than the cells we were using for screening where we kept them quiescent and then we stimulated them with TGF-β to activate them. These human cardiac fibroblasts from the failed human hearts are just on all the time.   Cindy St. Hilaire:        Wow.   Timothy McKinsey:    And SW does a really amazing job of reversing that activated state.   Cindy St. Hilaire:        Very cool and excellent resource I'm sure for future studies. So my last question is what's next? You know, you discovered a lot in this paper. What's the next thing you want to tackle?   Timothy McKinsey:    Cell type specific roles for 15-PGDH in the heart, in the control of cardiac homeostasis and disease. Basically we want to knock it out in fibroblasts. We want to knock it out in our macrophages and see what the consequences are. That's one thing. We want to really pursue the whole GPR31 12(S)-HETE pathway in the heart. That's something that has never been studied. And so GPR31 is a G protein coupled receptor that is bound by this eicosanoid called 12(S)-HETE. And that seems to be blocking fibroblast activation, so we're going to further pursue that pathway. And then we think that this paradoxical finding related to ERK signaling in the heart is also worthy of pursuit. Why is it that stimulating ERK in a cardiac fibroblast is actually blocking the activation state of that cell?   Marcello Rubino:        I'm interested in this like Tim says, but also interested in the role of the interaction of the cell because it's important to study like a specific gene inhibitor, whatever role in a specific cell, but what happened to the other cell, the interaction the other cell when you do knocking in some specific cell, so that's what I'm trying to do in general. Now I move back in Italy, like I told you, I'm like a kind of independent research and I'm studying a lot single cell sequencing right now. Try to do also try to see what happened to interaction, understand during pathology.   The idea is to study like inhibitor treatment and to see what really happened because gene expression is important, but we need to consider also of course the protein shape, the protein interaction, the cell interaction, so I try to grow in this field and see what really happened because the problem of the cell, they're just cell in vitro. They can mimic what happened, but it's not what really happened in vivo, so can we use this novel technology to improve our knowledge, that's what I want to try to do.   Cindy St. Hilaire:        Well that's great. Dr McKinsey, Dr Rubino, thank you so much for taking the time to speak with me today. Title of their article was Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart. It's in our January 6th issue of Circ Res. And thank you both so much for joining me today and thank you to you and all of your colleagues who worked so hard on this for this amazing study.   Timothy McKinsey:    Thank you. We really enjoyed this visit and we're grateful to have our work published in Circulation Research.   Cindy St. Hilaire:        That's it for highlights from the January 6th and 20th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes or #DiscoverCircRes. Thank you to our guests, Dr Tim McKinsey and Dr Marcello Rubino. This podcast is produced by Ishara Rantayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on-the-go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. The opinions expressed by the speakers of this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, please visit ahajournals.org.  

Your ability to suffer will determine your quality of life, if you can't handle the shit life throws at you, you won't be able to accept the gifts that life gives you. Shoutout to my fans worldwide, this podcast has reached the international level. I love you all very much, especially you Frankfurt

Imagine being an actress or an actor playing in two movies. Both soliloquies are based on unexpected heartbreaks that had so much hope in the beginning of these men being the one. Unfortunately both had a sad ending and this young lady had to confine herself in solitude to see where she went wrong. Listen and see why she had to walk away… --- Support this podcast: https://anchor.fm/nora421/support

Host Kevin Patton revisits some classic segments from past episodes. In the first segment, he explains why he thinks storytelling is the heart of effective teaching. Then. he tells a brief version of his actin-myosin love story—a playful analogy to help students learn about muscle contraction. 00:00 | Introduction 01:07 | Storytelling: The Heart of Teaching 15:36| Sponsored by AAA, HAPI, and HAPS 17:10 | Actin-Myosin Love Story 27:58 | Staying Connected ★ If you cannot see or activate the audio player, go to: theAPprofessor.org/podcast-episode-130.html

REAL MEN DRINK BEER, do you spend a lot of time with extended family, and what dollar amount is enough for you to become a personal assistant? All that and more on this weeks episode of "THHP".

Yo! I am taking a much needed break from dropping new episodes, but I will be back with more dope guests in a couple of months. In the meantime, enjoy some of my favorite episodes from the RTWD fault. Catch yall in a bit! From Episode 29 - Y‘all Actin‘ Cult-ish This week, I am joined by Mariah Poitier. Mariah (She/Her) is a Black Femme, Bay Area native and scholar-activist. She loves dismantling white supremacy almost as much as she loves to dance. She enjoys the NorCal and SoCal dual lifestyle, and procrastinating on her thesis. Mariah currently is a graduate student at San Francisco State University studying Master of Art in Education with a concentration in Equity and Social Justice (Update: SHE GRADUATED). I don't know if y'all noticed, but I have never really mentioned where I went to school and I still won't. Because trauma and you do not get free exposure for causing trauma. That's why I had a GREAT time talking with Mariah about her experiences at her grad school, her research, and what it's like living a double life in NorCal and SoCal. Stay in Touch with: ↳ Message Mariah on LinkedIn ↳ Email Mariah ↳ Mariah on IG Ways to support the show:    

1. Sacro + penia “Muscle” + “poverty” loss of muscle tissue as a natural part of the aging process. 2. Sarc + oma “Flesh” + “tumor” a malignant tumor of connective or other nonepithelial tissue. 3. Sarc + phagus “flesh/muscle” + “eating/consuming” (preceded it was the meaning “glutton”) a stone coffin, typically adorned with a sculpture or inscription and associated with the ancient civilizations of Egypt, Rome, and Greece. 4. Sacromere “muscle/flesh” + “part (meros)” a structural unit of a myofibril in striated muscle, consisting of a dark band and the nearer half of each adjacent pale band. 5. Sarco + lemma “Flesh” + “husk” the fine transparent tubular sheath which envelops the fibers of skeletal muscles. 6. “Auto”+ “phagy” “Self” + “consuming” the body's way of cleaning out damaged cells, in order to regenerate newer, healthier cells. 7. Phagocytes “Phago” “cytes(kutos)” = vessel Cyte refers to a type of cell cells that protect the body by ingesting harmful foreign particles, bacteria, and dead or dying cells 8. Marco - phage “Large” + “eating/eater” - a large phagocytic cell found in stationary form in the tissues or as a mobile white blood cell, especially at sites of infection 9. Actin - From Ancient Greek ἀκτίς (aktís, “ray”), based on the shape of the filament formed, and the English chemical suffix -in. 10. Myosin - myo- (“relating to muscle/flesh”), from Ancient Greek μυός (muós), genitive of μῦς (mûs, “muscle”) + -in, the english chemical suffix mentioned prior. Actin and myosin are both proteins that are found in all types of muscle tissue (aka sarcomeres = actin + myosin). Myosin forms thick filaments (15 nm in diameter) and actin forms thinner filaments (7nm in diameter). Actin and myosin filaments work together to generate force. 11. Nanometer - one billionth of a meter. prefix nano- (from the Ancient Greek νάνος, nanos, "dwarf") with the combination of the name metre (from Greek μέτρον, metrοn, "unit of measurement"). 12. Cytopenia (“cyto” + “penia”) “cell/vessel” + “poverty, deficiency, lack of” A deficiency in the production of one or more types of blood cells is called cytopenia. This condition may be caused by liver disorders, poor kidney function, and chronic inflammatory diseases. 12. Thrombocytopenia (thrombo-cyto-penia): Thrombocytes are platelets, and thrombocytopenia is the condition of having an abnormally low platelet count in the blood. “thrombo(to clot/to lump)” + “cyto(vessel/cell)” + “poverty, deficiency” --- Support this podcast: https://anchor.fm/liam-connerly/support

More RnB songs to get the mood right

Josh & Randy are back this week on the podcast for an in-depth look back at Actin' Up from 5/28 featuring Alec Price vs. Lince Dorado, Beef's impressive return + challenge, a surprise appearance from Channing Thomas, and a look ahead to the 2022 Vacationland Cup!

Today on the show Dj Envy and Charlamagne acted out, as Yee was out of town. During the show, they played an interview with Charlamagne and Jay Pharoah speaking about Trauma Triggers, leaving SNL, purpose, new projects and more. Also, after playing clips from Careesha interview with Diddy, they opened the phone lines to see if our listeners are similar to the City Girl dating someone with a big age gap. Also, Charlamagne gave "Donkey of the Day" to a Floridian who was bitten by a alligator he mistaken as a dog.  See omnystudio.com/listener for privacy information.