Podcasts about proteins

Full show notes: https://bengreenfieldlife.com/saunapodcast In this episode with Luke Chapman and Owen Buchanan, founders of Western Sol, you'll hear the story behind the custom sauna I recently had built in my backyard in Idaho, and the story behind the company itself, which started when a mold exposure in Hawaii sent Luke into daily sauna use. You'll gain insights into the actual science of heat shock proteins and dynorphins (the opioid peptides your body releases under heat stress), why most sauna wood is loaded with VOCs, and how thermally pressed aspen and spruce sourced from Estonia solves that problem entirely. We'll also touch on how Western Sol engineers oxygen-rich air recirculation, Himalayan salt therapy, and even full electrical grounding directly into the sauna floor, and you'll get a full walkthrough of what it costs to get a custom or prefabricated sauna built. Luke Chapman and Owen Buchanan are the founders of Western Sol, a custom and prefabricated sauna company based in Idaho. Both grew up around custom home construction in their family businesses before turning their focus toward building non-toxic, low-VOC saunas designed to support healing of the mind, body, and soul. They travel throughout Europe to source materials and study traditional sauna culture at its origin. You can find out more about Western Sol and schedule a free consultation here. Episode Sponsors: Dr. Murray Natural Products ThymoQuin: A clinically researched black seed oil formulated to support healthy cortisol levels and resilience to everyday stress. Visit doctormurray.com/ben and use code BEN25 for 25% off. Manukora: Honey with superpowers. Head to manukora.com/ben or use code BEN to get $25 off your Starter Kit. Just Thrive: The Gut Essentials Bundle pairs a probiotic clinically proven to arrive 100% alive in your gut with Digestive Bitters, a blend of 12 science-backed herbs. Visit justthrivehealth.com/BEN and save 20% with code BEN, or get a full refund if you don't notice a difference. ULTRA: A clean, nicotine-free, caffeine-free pouch delivering smooth, sustained energy and focus using clinically backed nootropics and adaptogens. Visit takeultra.com and use code BENGREENFIELD for 15% off. TruDiagnostic: An advanced at-home epigenetic test measuring over a million biomarkers for personalized insights into aging, energy, and overall health. Visit TruDiagnostic.com and use code BEN20 for 20% off. BON CHARGE: A holistic wellness brand with products that address sleep, performance, recovery, hormone balance, and inflammation. Go to boncharge.com/GREENFIELD and use code GREENFIELD to save 15%.See omnystudio.com/listener for privacy information.

Why are bigger portions and premium proteins reshaping pizza choices in 2026? Discover how shareable feasts, meat-loaded specialty pizzas, and local pizzerias are winning over families and groups seeking bold, elevated dining experiences. To learn more, visit https://westsidepizza.com/location/colfax/ Westside Pizza - Colfax, WA City: Colfax Address: 208 1/2 N Main Street Website: https://westsidepizza.com/locations/colfax/

Did you know the very medication doctors push to "protect" your heart could be wrecking your brain, hormones, and mood? I've watched statins destroy lives, including my father's, and it's time to address the issues with the meds. I am joined by chiropractor Joel Boheimer, founder of the supplement line Regenerate, to break down why nattokinase is gaining popularity for heart health. Joel walks us through the research behind this fibrin-dissolving enzyme. He explains why cholesterol isn't the villain we've been told it is, and how the wrong form of calcium affects your arteries and joints. We also get into vitamin K2, ellagic acid, and why regenerative, whole-food sourcing changes everything about how a supplement performs in your body.  If you're worried about your heart or just tired of being handed a prescription instead of an explanation, this conversation will change how you think about your next cardiologist visit.   "Research shows that higher levels of cholesterol are protective to longevity, heart attack, strokes, and cancers." ~  Dr. Joel Bohemier   In This Episode: - What is nattokinase, and what are its benefits? - Why statins are dangerous - Statins linked to rise in dementia - Nattokinase use after 2020 jabs  - Regenerate's farming philosophy - The research behind Regenerate's supplements - An overview of CardioNK's ingredients  - Vitamin K2 and calcium placement  - Ellagic acid and urolithins - Bacillus subtilis and gut health benefits - Where to get CardioNK and recommended dosage   Products & Resources Mentioned: Regenerate's CardioNK: Get it at a special discount at: https://regeneratecompany.com/pages/myers?uid=2&oid=2&affid=9  Bon Charge Red Light Face Mask: Get 15% off sitewide, plus free shipping and a 12-month warranty, with code WENDY at https://boncharge.com/     Tru Energy Skincare Bio Adaptive Hydration Oil: Try the oil and save up to $197 at trytruenergy.com/wendy5 Organifi Collagen: Save 20% with code MYERSDETOX at https://organifi.com/myersdetox  Heavy Metals Quiz: Take the quiz at https://heavymetalsquiz.com    About Dr. Joel Bohemier: Dr. Joel Bohemier is a second-generation chiropractor and founder of Regenerate, a supplement company built on a simple idea: the health of people and the health of the planet are connected. A longtime advocate for natural health and medical freedom, Dr. Bohemier has spent his career helping people take ownership of their health rather than just manage symptoms. He owns several chiropractic and wellness practices in Southwest Florida and is a frequent speaker on organic nutrition, detoxification, and regenerative health. He co-founded Stand for Health Freedom, serves on the advisory board of GreenMedInfo.com, and is a member of the Global Wellness Forum's Legislative Innovation Council. Learn more about Regenerate supplements at https://regeneratecompany.com/    Disclaimer The Myers Detox Podcast was created and hosted by Dr. Wendy Myers. This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast, including Wendy Myers and the producers, disclaims responsibility for any possible adverse effects from using the information contained herein. The opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Today I'm sitting down with Randy Teel, Ph.D., President and CEO of Arvinas, a clinical-stage biotech based in New Haven, Connecticut, that is doing something genuinely new in medicine.Arvinas is pioneering a technology called PROTAC protein degradation. It's a platform that doesn't just block disease-causing proteins, but eliminates them entirely using the body's own disposal system to do it. It's a fundamental shift in how we think about drug design, and it's now reached a historic milestone: the first PROTAC ever to succeed in a Phase 3 clinical trial, with a regulatory filing now in front of the FDA.01:19     Meet Randy Teel 03:41     Stepping into the CEO role in February 2026 13:17     What is a PROTAC and how it works 17:37     Vepdegestrant and the first PROTAC approval 23:43     Balancing partnerships versus keeping control of assets 31:57     Key milestones to watch in the next 12–18 monthsInterested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletterTo dive deeper into the topic: From undruggable to oral therapy: The rise of STAT6 degradersBig Pharma Strikes Megadeals In Targeted Protein DegradationThis Biotech Destroys Cancer Proteins by Introducing Them to ‘Executioner' Proteins

This episode is sponsored by Notion. Learn more about Notion's Developer Platform today at https://notion.com/mlstProtein folding stalled biology for fifty years. A sequence of amino acids dictates a three-dimensional shape, but reading that shape meant a year and roughly $100,000 of crystallography per structure. Then AlphaFold 2 won CASP14 so decisively the organizers called the problem essentially solved.In this documentary cut, John Jumper, who shared the 2024 Nobel Prize in Chemistry and has since left DeepMind for Anthropic, walks Tim Scarfe through what the system did and, more interestingly, what it did not. The architecture gets a proper dissection: MSAs, the Evoformer, invariant point attention, the FAPE loss, and Jumper's correction of the equivariance story, which ablations valued at roughly 2.5 of 30 GDT points rather than the whole win. He is blunt about the limits. AlphaFold predicts one experiment extraordinarily well; it is not a model of the cell, it does not capture dynamics, and on a given drug target it is "wrong nine times out of ten."From there: the AlphaFold Database of 200M+ predicted structures, AlphaFold 3 and ligands, Isomorphic Labs, and Jumper's quarrel with the bitter lesson, where finite data and human hypotheses still matter. Emmanuel Nji of BioStruct Africa closes the film on what changes when work that took years now takes months, and on training the next thousand structural biologists across Africa.---TIMESTAMPS:00:00:00 Cold open: predicting nature with a button press00:01:03 The protein folding bottleneck and CASP00:04:39 The Nobel, the database, and the move to Anthropic00:05:50 Sponsor (Notion) and framing: what AlphaFold does not claim00:07:39 Proteins as self-assembling nanomachines00:12:24 From structures to biology: drug discovery and Midnolin00:17:37 The humility of AlphaFold: a narrow predictor00:22:18 Inside the architecture: Evoformer, IPA and FAPE00:30:20 Ruthless empiricism: ablations and 100x in data00:35:20 Predict, control, understand00:40:00 Against the bitter lesson; AlphaFold 3 as diffusion00:45:07 Intelligence, representations and AGI00:49:23 Epilogue: AlphaFold in Africa00:52:16 Closing: the case for hybrid science models---REFERENCES:organization:[00:01:55] Critical Assessment of Structure Prediction (CASP)https://predictioncenter.org/[00:04:39] The Nobel Prize in Chemistry 2024https://www.nobelprize.org/prizes/chemistry/2024/summary/[00:05:18] BioStruct Africahttps://www.biostructafrica.org/[00:18:03] Isomorphic Labshttps://www.isomorphiclabs.com/paper:[00:03:09] AlphaFold Protein Structure Databasehttps://doi.org/10.1093/nar/gkab1061[00:17:25] Accurate structure prediction of biomolecular interactions with AlphaFold 3https://www.nature.com/articles/s41586-024-07487-w[00:22:18] Highly accurate protein structure prediction with AlphaFoldhttps://www.nature.com/articles/s41586-021-03819-2[00:23:10] Midnolin promotes degradation of substrates independent of ubiquitinationhttps://doi.org/10.1126/science.adh5021[00:27:00] Improved protein structure prediction using potentials from deep learninghttps://www.nature.com/articles/s41586-019-1923-7tool:[00:03:09] AlphaFold Protein Structure Database (EBI)https://alphafold.ebi.ac.uk/[00:45:55] AlphaEvolve: a coding agent for designing advanced algorithmshttps://deepmind.google/blog/alphaevolve-a-gemini-powered-coding-agent-for-designing-advanced-algorithms/other:[00:39:40] The Bitter Lessonhttp://www.incompleteideas.net/IncIdeas/BitterLesson.html---ReScript: https://app.rescript.info/share/d8cde5c221fb71e2c0f5aafe94f90dfaDisclaimer - not sponsored, editorial with us - we filmed it at GDM, London

People are shopping for fruit and veggies over meat as more start weight loss drugs. A report from fresh produce group United Fresh has identified a shift in grocery patterns, with more opting for fresh produce rather than processed foods. Berries, avocados, and kiwifruit have had the biggest growth in value. President Jerry Prendergast told Mike Hosking they're not bad things for people to eat. He says people are looking for fresh produce as a lighter alternative, instead of heavy protein they may have eaten in the past. LISTEN ABOVE See omnystudio.com/listener for privacy information.

Sugar-Free Diets Disrupted Gut Microbiome and Metabolism A 16-week sucrose-free, low-fat diet study presented at ENDO 2026 found mice developed insulin resistance, impaired glucose tolerance, gut microbiome imbalance, intestinal inflammation, and fatty liver disease signs despite no weight gain or calorie difference. Host Dave Asprey breaks down why eliminating sugar entirely may be more detrimental than previously thought, the gut-bacteria-to-metabolism cascade that explains the metabolic damage, and why balanced nutrition matters more than simply removing sugar from your stack. Sources: https://www.sciencedaily.com/releases/2026/06/260614011843.htm https://www.medicalnewstoday.com/articles/how-eliminating-sugar-may-alter-the-gut-microbiome-mouse-study https://nypost.com/2026/06/13/health/going-sugar-free-can-mess-with-your-gut-and-metabolism/ ~~ Taurine Did Not Boost Acute Aerobic Performance A randomized, triple-blind, cross-over study of 16 physically active young adults found acute 1-gram taurine ingestion one hour before exercise produced no significant improvements in peak oxygen consumption, time to exhaustion, respiratory compensation point, or lipid/glycolytic metabolism variables. Host Dave Asprey explains why taurine remains popular in energy drinks and pre-workouts despite limited scientific evidence, what dosages and activity types future research should test, and why a reality check on a billion-dollar supplement category is exactly the kind of truth biohackers need. Sources: https://pubmed.ncbi.nlm.nih.gov/42268287/ https://www.sciencedaily.com/releases/2026/06/260611024609.htm ~~ Copper Therapy Improved Memory and Reduced Alzheimer's Proteins in Mice Lab trials from Monash University published in ACS Chemical Neuroscience found Cu(ATSM), a copper-delivery compound, increased P-glycoprotein abundance by 24.1 percent at the blood-brain barrier, reduced toxic amyloid-beta by 42 percent over 56 days, and improved spatial learning by nearly 44 percent in an Alzheimer's mouse model. Host Dave Asprey breaks down why repairing the brain's waste-clearing pump is a potential new therapeutic avenue for neurovascular dysfunction, why Cu(ATSM) has strong potential to fast-track into human clinics since it's already tested for Parkinson's and ALS, and why biometal therapies like this could be the next frontier in Alzheimer's treatment. Sources: https://www.news-medical.net/news/20260615/Lab-trials-prove-copper-therapy-enhances-cognitive-function-and-spatial-learning.aspx https://www.monash.edu/news/articles/copper-drug-restores-memory-and-clears-toxic-alzheimers-proteins https://pubs.acs.org/doi/10.1021/acschemneuro.6c00252 ~~ Socioeconomic Factors Biologically Embedded in Children's Brains A study of 2,300+ 9- and 10-year-olds published in Science found socioeconomic factors—household income, education, neighborhood quality—were the dominant variable affecting brain development, with MRI-visible differences in sensory processing and motor control regions linked to less sleep, more stress, and higher social media use in lower-income neighborhoods. Host Dave Asprey explains why socioeconomics became “biologically embedded” in preteen brains, how sleep-stress-screen circuits alter wakefulness and alertness, and why earlier studies focusing on IQ or mental health without accounting for environment may require reevaluation. Sources: https://www.npr.org/2026/06/11/nx-s1-5849937/child-brain-development-stress-sleep-neighborhood-economics https://abcdstudy.org/ ~~ Strength Training Sweet Spot for Longevity Is 90–120 Minutes Per Week A 30-year observational study of 147,374 participants published in the British Journal of Sports Medicine found 90–119 minutes per week of strength training delivered 13 percent lower all-cause mortality, 19 percent lower cardiovascular mortality, and 27 percent lower neurological mortality, with no additional benefit above 120 minutes. Host Dave Asprey breaks down why more isn't always better when it comes to resistance training, why combining strength with aerobic exercise dropped mortality risk by 45–58 percent at highest levels, and why 15–20 minutes a day or 30–40 minutes three times weekly is the minimum effective dose for longevity. Sources: https://www.sciencedaily.com/releases/2026/06/260611024609.htm https://academic.oup.com/sleep/article/48/8/zsaf127/8129074 https://www.bmj.com/content/bsjspor/early/2025/06/11/bjsports-2025-110503 ~~ This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on sugar-free diet metabolic risks, taurine supplement efficacy, copper-based Alzheimer's therapeutics, childhood environmental brain development, and strength training longevity dosing. Host Dave Asprey connects preclinical animal data, randomized human trials, observational cohort research, and population neuroscience into actionable frameworks for extending healthspan, optimizing metabolism, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: sugar-free diet gut microbiome, insulin resistance sugar elimination, taurine aerobic performance, taurine supplement myths, Cu(ATSM) copper Alzheimer's therapy, blood-brain barrier P-glycoprotein, amyloid-beta reduction copper drug, spatial learning Alzheimer's mouse, socioeconomic brain development children, ABCD Study brain MRI, childhood biohacking environment, strength training longevity 90-120 minutes, British Journal Sports Medicine strength, weekly strength training dose, all-cause mortality resistance training, biohacking news 2026, longevity researchThank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Intro 0:20 – Story 1: Copper & Alzheimer's 2:42 – Story 2: Sugar-Free Diet 4:05 – Story 3: Strength Training Minimum Dose 5:48 – Story 4: Childhood Environment & Brain Development 7:42 – Story 5: Taurine 9:49 - Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Though almost driven to extinction in the 1800s, this massive bovine has made a comeback – thanks in part to the popularity of its rich meat. Anney and Lauren herd together the history and science behind American bison.See omnystudio.com/listener for privacy information.

Check out the next episode of our podcast, Under the Surface. In episode 16, When Proteins Move: Woody Sherman on Computational Chemistry, Molecular Simulation, and the Future of AI in Drug Discovery, we chat with Woody Sherman, Founder and Chief Innovation Officer at PsiThera, and a longtime leader in computational chemistry, about how he went from studying quantum polymers to shaping modern tools like Induced Fit Docking.  Woody shares the moment that pulled him into protein simulations, his early exposure to AI at MIT, and how an internship at Biogen set him on the path to industry. He also reflects on his years at Schrödinger, building solutions, writing code, and learning how to solve real problems for scientists. Topics: How application scientists help connect research with real-world industry needs Woody's journey from university research to starting Silicon Therapeutics How tools like induced fit docking were created How drug discovery platforms have changed over time What's different between working in industry and in academia What's next for open molecular software and AI working together (02:05) Why mentorship matters for scientists (04:15) Woody's path through school and research (09:10) Shifting into custom molecular simulations (12:00) Going from the academic world to industry (15:00) Creating new tools for drug discovery at Schrodinger (22:10) Putting together a team of experts (26:15) Working together on drug design platforms (34:00) Leading application science teams around the world (41:45) Starting up Silicon Therapeutics (45:58) Progress in the development of the STING agonist medicine (49:00) Launching PsiThera (56:30) Focusing on inflammation and the immune system (60:15) Sharing science and data openly (69:00) How AI will shape the future of drug discovery (80:30) What Woody enjoys outside of work (82:20) Final thoughts and getting involved with the community Listener discretion is advised.  

Gugs Mhlungu is joined by Tanya Albert, Dietician and Health Coach, unpacking the growing interest in peptides; what peptides are, how they differ from proteins, their potential health benefits, and what consumers should know about using them safely. Gugs Mhlungu gets you ready for the weekend each Saturday and Sunday morning on 702. She is your weekend wake-up companion, with all you need to know for your weekend. The topics Gugs covers range from lifestyle, family, health, and fitness to books, motoring, cooking, culture, and what is happening on the weekend in 702land. Thank you for listening to a podcast from 702 Weekend Breakfast with Gugs Mhlungu. Listen live on Primedia+ on Saturdays and Sundays from 06:00 and 10:00 (SA Time) to Weekend Breakfast with Gugs Mhlungu broadcast on 702 https://buff.ly/gk3y0Kj For more from the show go to https://buff.ly/u3Sf7Zy or find all the catch-up podcasts here https://buff.ly/BIXS7AL Subscribe to the 702 daily and weekly newsletters https://buff.ly/v5mfetc Follow us on social media: 702 on Facebook: https://www.facebook.com/TalkRadio702 702 on TikTok: https://www.tiktok.com/@talkradio702 702 on Instagram: https://www.instagram.com/talkradio702/ 702 on X: https://x.com/Radio702 702 on YouTube: https://www.youtube.com/@radio702 See omnystudio.com/listener for privacy information.

In the first episode of our new series “Nutrition Myths Fact-Checked”, nutritional therapist Eva-Maria Heikenwalder talks about the role of proteins and carbohydrates. She also dismantles the hype surrounding the carnivore diet and explains where facts end and nonsensical myths begin. She tells us her best recipe for a diet suitable for everyday use and gives practical tips on how to recognize reputable nutrition tips online. - In der ersten Folge unserer neuen Reihe "Ernährungsmythen im Faktencheck" spricht Ernährungstherapeutin Eva-Maria Heikenwälder über die Rolle von Proteinen und Kohlenhydraten. Außerdem nimmt sie den Hype um die Carnivore-Diät auseinander und erklärt, wo Fakten enden und unsinnige Mythen anfangen. Sie verrät uns ihr bestes Rezept für eine alltagstaugliche Diät und gibt praktische Tipps, woran man im Netz seriöse Ernährungstipps erkennt.

Learn how raw food boosts energy, plant proteins meet nutritional needs, and healthy fats and seeds reduce disease risk. #RawFoodEnergy #PlantProteins #HealthyFats

Editor's note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions of protein sequences drawn from across life, with a simple “next token” objective: predict the amino acids that have been randomly masked out, based on the context of the rest of the sequence. But they soon found that these models also learned biological structure and function, including properties the model had never been explicitly shown AND that this ability scales predictably with compute, leading to ESM2 and ESM3.Today, Alex announced ESMFold 2, an open scientific engine to power prediction, design, and discovery across protein biology.Building on Cryo-EM data (discussed in the CZI pod), ESMFold2 reports state of the art performance on protein interactions, especially antibodies, a critical modality for therapeutics, and evidence that inference time scaling is also working across five targets in cancer and immunology.In a nod to that other famous AI x protein folding project, they are also releasing an atlas of 6.8 billion proteins, and 1.1 billion predicted structures, which you can play around with on their website. We are honored to work with them for this huge release!One of the refrains we've heard on the Science pod has been that protein folding, materials design, cellular biology, etc. are very different problems from Language Modeling. They definitely are. Yet Alex Rives and the ESM team at BioHub just released a preprint and model, demonstrating that vanilla BERT-like transformer models trained on sufficiently large and diverse data sets can beat specialized models like AlphaFold3 on some of the hardest protein-related problems. Andrew White had a great segment in our first LS-Science episode that explained how mind blowing AlphaFold2 was when it was released in 2020: it suddenly solved problems on a GPU on your desktop that DESRes had built custom-ASIC supercomputer clusters to solve. John Jumper and Demmis Hassabis received the Nobel Prize in Chemistry for this work.AlphaFold2 took advantage of an very clever observation: if multiple species co-evolve pairs of mutations, this implies that the mutations correspond to parts of the protein that are close in 3d space. This is usually shorthanded as MSAs (multi-sequence alignments), and is the key insight which makes AlphaFold2 so effective.Like other inductive biases, however, it hurts generalization.Scale-pilled before it was coolIf you take a look at the timeline for scaling laws for LLMs and release of structure prediction models, the ESM team notably doubled down on their MSAs-be-damned approach after AlphaFold2 released. This obviously requires a great deal of belief in the scale hypothesis.Why the conviction?ESM developed at a time when many of the scaling laws and the “Bitter Lesson” were proving increasingly correct. AlphaFold2's wild success must have been both exciting and bitterly disappointing. But using MSAs mean that the model is is dependent on training data that contains MSAs in order to be accurate in a given domain. For things like antibodies that don't have MSAs to train on, AlphaFold tends to do poorly.ESM takes a different approach: learn the relationship between different proteins by unsupervised training on as much diversity as you can find (sound familiar?) and then correlate that back to structures know from the Protein Data Bank (PDB) and other sources. In other words, a World Model.World Model for proteins“World Model” is a hype term that I define like this:Use unsupervised training to learn abstract patterns from the data:* The abstraction should be semantic - novel constructions represent things that obey the rules of the real world* The abstraction should be compositional - recombining different patterns leads to novel and often valid constructions* The abstraction should support generalization - it predicts things in the real world it wasn't trained on Once you have a world model, you can attach “heads” to it for downstream tasks: predict properties of a protein, decompose its functional features, or search the representation for proteins that meet design criteria. The two big models BioHub just released under MIT license map directly onto this:* World model → ESMC (a model trained on 2.8 billion sequences)* Structure-prediction head → ESMFold2One of the interesting ways the world model can “predict things” is to generate proteins sequences and then measure the predicted properties, such as binding affinity, in the lab. Alex talks in the episode about validating some of the harder molecules they predicted in the wet-lab. Very cool!Another way is to use mech-interp techniques such as Sparse Auto Encoders (SAEs) to extract semantic features from your model, and then find novel features that predict unknown biology. I won't spoil this part for you: it was one of the highlights of the episode for me!A cell is a computerWe have all heard that genes are like computer programs, but usually the analogy fizzles after that. Of course genes are transcribed into RNA and RNA is translated into proteins, so genes are programs for building proteins, but that carries the analogy only to “binary digits are programs.” Here's a better analogy: you can think of the cell nucleus as a storage device / storage controller, the ribosome as a JIT-compiler and runtime, and the semantic features that we learn from our world model via SAEs as functions, proteins as processes that interact together in workflows (signalling pathways) to produce behaviors and outputs (phenotypes). Like functions, the SAE features have a hierarchical composition from local, secondary and tertiary structures (mimicing protein structure), but also motifs that are conceptual, such as membrane integrations, disordered regions and disulfide bonds. As we learn to compose these features we into novel protein designs, we move further towards programmable biology. Alex goes into much more detail about this in the episode, as well as:* Principles for new data collection* BioHub's vision* Modeling the cellEnjoy!Full Video podcastplease like and subscribe!* X: https://x.com/alexrives* LinkedIn: This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.latent.space/subscribe

What if one of the most promising frontiers in Alzheimer's research isn't just about what's building up in the brain - but how the brain clears it out? In this episode of Research Renaissance, host Deborah Westphal sits down with Dr. Tirth Patel, a neurologist and physician-scientist at UCLA and 2025 Toffler Scholar, to explore the cutting-edge science of brain clearance, tau protein, and the newly discovered lymphatic vessels surrounding the brain.This is a conversation about curiosity, persistence, and the kind of early-career science that could reshape how we understand and treat dementia.What You'll Learn in This EpisodeWhat tau protein is, why it "gunks up" the brain, and how it differs from amyloid beta in Alzheimer's diseaseThe recently discovered lymphatic vessels in the brain's meninges - and why they matter for clearing toxic proteinsHow sleep deprivation spikes tau and amyloid levels in the blood, and what that means for long-term brain healthThe glymphatic system: the brain's internal waste-clearance highway and its deep connection to sleepWhy aging slows down the brain's lymphatic drainage - and what researchers are doing about itThe genetics of Alzheimer's: the difference between causative mutations (APP, PS1, PS2) and risk factors like APOE4New FDA-approved blood tests and the promise of tau PET scans for better diagnosis and stagingThe latest treatments for Alzheimer's - how they work, their limitations, and what's coming nextWhy failure is one of the most undervalued tools in science - and what's missing in how the field handles negative dataA candid take on AI in biological research: where it helps, where it falls short, and whether it lets scientists failAbout Our GuestDr. Tirth Patel is a neurologist and physician-scientist at UCLA, currently working in the lab of Dr. Jason Hinman. His research focuses on how the brain's meningeal lymphatic vessels clear tau protein from the brain to the bloodstream - a question with major implications for Alzheimer's disease and related dementias. Dr. Patel is a 2025 Toffler Scholar, supported by the Karen Toffler Charitable Trust. He is also the co-host of the podcast Recreational Science, where he and his colleague Dr. Lou Yang explore wacky but well-designed scientific studies to illuminate the scientific method.

Sir Demis Hassabis (geboren am 27. Juli 1976 in London) ist ein britischer KI-Forscher, Neurowissenschaftler und Unternehmer. Er ist Mitbegründer und CEO von Google DeepMind sowie Gründer von Isomorphic Labs. Im Jahr 2024 wurde ihm gemeinsam mit John Jumper der Nobelpreis für Chemie für die Entwicklung von AlphaFold verliehen, einem System zur Vorhersage von Proteinstrukturen.Hassabis gilt als vielseitiges Genie mit Hintergründen in den Bereichen Spiele, Informatik und Neurowissenschaften.Schach und Spiele: Er war ein Wunderkind im Schach, erreichte im Alter von 13 Jahren das Master-Niveau und führte mehrere englische Jugendteams an. Mit 17 Jahren war er federführend an der Programmierung und dem Design des millionenfach verkauften Simulationsspiels Theme Park beteiligt.Akademische Ausbildung: Er schloss sein Informatikstudium an der University of Cambridge 1997 mit Auszeichnung ab und promovierte 2009 in kognitiven Neurowissenschaften am University College London (UCL). Seine Forschung über den Zusammenhang zwischen Gedächtnis und Vorstellungskraft wurde vom Fachjournal Science als einer der zehn wichtigsten wissenschaftlichen Durchbrüche des Jahres 2007 gewürdigt.Hassabis gründete DeepMind im Jahr 2010 mit der Mission, „Intelligenz zu lösen“ und dieses Wissen zur Lösung globaler wissenschaftlicher Probleme einzusetzen.AlphaGo: Unter seiner Leitung besiegte das Programm AlphaGo 2016 den Weltmeister Lee Sedol im komplexen Spiel Go, was als Meilenstein der KI-Geschichte gilt.AlphaFold: Das Team um Hassabis und Jumper löste mit AlphaFold ein seit 50 Jahren bestehendes Problem der Biologie: die präzise Vorhersage der 3D-Struktur eines Proteins allein anhand seiner Aminosäuresequenz. Diese Technologie wurde der Fachwelt kostenlos in einer Datenbank mit über 200 Millionen Strukturen zur Verfügung gestellt.Wissenschaftliche Vision: Hassabis betrachtet die Biologie als ein Informationsverarbeitungssystem und sieht KI als ultimatives Werkzeug, um wissenschaftliche Entdeckungen in Bereichen wie der Arzneimittelforschung und Materialwissenschaft massiv zu beschleunigen.Hassabis ist ein prominenter Mahner für eine verantwortungsvolle KI-Entwicklung. Er plädiert für intensive Sicherheitsforschung und unterzeichnete eine Erklärung, die das Risiko eines KI-bedingten Aussterbens auf eine Stufe mit Pandemien oder einem Atomkrieg stellt. Gleichzeitig lehnt er eine Pause der KI-Entwicklung ab, da die potenziellen Vorteile für Gesundheit und Klima zu bedeutend seien.Neben dem Nobelpreis erhielt er zahlreiche weitere Ehrungen:Er wurde 2024 für seine Verdienste um die künstliche Intelligenz zum Ritter geschlagen.Er erhielt den Albert Lasker Award (2023) und den Breakthrough Prize in Life Sciences (2023).Das Time Magazine listete ihn mehrfach unter den 100 einflussreichsten Personen der Welt.Werdegang und frühe LeistungenDeepMind und AlphaFoldSicherheit und EthikAuszeichnungen

Sir Demis Hassabis (geboren am 27. Juli 1976 in London) ist ein britischer KI-Forscher, Neurowissenschaftler und Unternehmer. Er ist Mitbegründer und CEO von Google DeepMind sowie Gründer von Isomorphic Labs. Im Jahr 2024 wurde ihm gemeinsam mit John Jumper der Nobelpreis für Chemie für die Entwicklung von AlphaFold verliehen, einem System zur Vorhersage von Proteinstrukturen.Hassabis gilt als vielseitiges Genie mit Hintergründen in den Bereichen Spiele, Informatik und Neurowissenschaften.Schach und Spiele: Er war ein Wunderkind im Schach, erreichte im Alter von 13 Jahren das Master-Niveau und führte mehrere englische Jugendteams an. Mit 17 Jahren war er federführend an der Programmierung und dem Design des millionenfach verkauften Simulationsspiels Theme Park beteiligt.Akademische Ausbildung: Er schloss sein Informatikstudium an der University of Cambridge 1997 mit Auszeichnung ab und promovierte 2009 in kognitiven Neurowissenschaften am University College London (UCL). Seine Forschung über den Zusammenhang zwischen Gedächtnis und Vorstellungskraft wurde vom Fachjournal Science als einer der zehn wichtigsten wissenschaftlichen Durchbrüche des Jahres 2007 gewürdigt.Hassabis gründete DeepMind im Jahr 2010 mit der Mission, „Intelligenz zu lösen“ und dieses Wissen zur Lösung globaler wissenschaftlicher Probleme einzusetzen.AlphaGo: Unter seiner Leitung besiegte das Programm AlphaGo 2016 den Weltmeister Lee Sedol im komplexen Spiel Go, was als Meilenstein der KI-Geschichte gilt.AlphaFold: Das Team um Hassabis und Jumper löste mit AlphaFold ein seit 50 Jahren bestehendes Problem der Biologie: die präzise Vorhersage der 3D-Struktur eines Proteins allein anhand seiner Aminosäuresequenz. Diese Technologie wurde der Fachwelt kostenlos in einer Datenbank mit über 200 Millionen Strukturen zur Verfügung gestellt.Wissenschaftliche Vision: Hassabis betrachtet die Biologie als ein Informationsverarbeitungssystem und sieht KI als ultimatives Werkzeug, um wissenschaftliche Entdeckungen in Bereichen wie der Arzneimittelforschung und Materialwissenschaft massiv zu beschleunigen.Hassabis ist ein prominenter Mahner für eine verantwortungsvolle KI-Entwicklung. Er plädiert für intensive Sicherheitsforschung und unterzeichnete eine Erklärung, die das Risiko eines KI-bedingten Aussterbens auf eine Stufe mit Pandemien oder einem Atomkrieg stellt. Gleichzeitig lehnt er eine Pause der KI-Entwicklung ab, da die potenziellen Vorteile für Gesundheit und Klima zu bedeutend seien.Neben dem Nobelpreis erhielt er zahlreiche weitere Ehrungen:Er wurde 2024 für seine Verdienste um die künstliche Intelligenz zum Ritter geschlagen.Er erhielt den Albert Lasker Award (2023) und den Breakthrough Prize in Life Sciences (2023).Das Time Magazine listete ihn mehrfach unter den 100 einflussreichsten Personen der Welt.Werdegang und frühe LeistungenDeepMind und AlphaFoldSicherheit und EthikAuszeichnungen

(May 15, 2026) IT’S FOODIE FRIDAY! Food enthusiast and host of ‘The Fork Report’ on KFI Neil Saavedra joins Bill to talk about Taco Bell releasing a new Mexican pizza flavor, the Force Meat Sandwich, and whether Flowers are the next plant protein? The show closes with ‘Ask Handel Anything.’See omnystudio.com/listener for privacy information.

Rarely does a conversation cut this deeply into one of modern society's most ignored crises. Joe Bartosch and Robert Jessel join Dr. Ryan Willert and Pastor Mike Wrigglesworth to discuss their book Pornocracy, a term they use to describe a system quietly reshaping beliefs about self-image, gender, and relationships in ways most people never stop to examine.The numbers and patterns they describe are genuinely unsettling. Increased cosmetic surgery among young women, declining birth rates, and children exposed to extreme content by their early teens point to something larger than individual choices. The authors introduce the concept of "limbic capitalism," explaining how platforms deliberately exploit the brain's reward system, serving progressively extreme content as people become desensitized. Proteins like Delta-FosB physically harden neural pathways (which means these patterns become genuinely difficult to reverse over time).What does it mean when society stops stigmatizing things that cause real harm? That question sits at the heart of everything Bartosch and Jessel are arguing. They also address the manosphere, school sex education, the consent debate, and OnlyFans, connecting these threads into a broader cultural picture.Honestly, this conversation covers ground that most people avoid covering entirely. Tune in to hear the full discussion.CHAPTERS:00:00:02 - Introducing Pornocracy: A Critical Conversation00:01:54 - Pornography's Impact on Society and Relationships00:08:39 - Porn Platforms Use Addiction Tactics Like Social Media00:12:24 - Pornography's Neurochemical Effects on the Brain00:16:42 - Social Media Insecurity and Self-Commodification in Youth00:19:21 - Pornography's Impact on Children and Parental Strategies00:22:37 - Protecting Children from Digital Devices00:26:50 - Patriarchy, Pornography, and Male Objectification00:30:28 - Humanity, Vulnerability, and Education System Concerns00:33:51 - The Problem With Sex Education in Schools00:36:33 - Consent Culture and Porn Industry Exploitation00:40:30 - Consent Alone Isn't Sufficient00:44:13 - Pornography's Power: Institutional Blindness and Complicity00:47:25 - Trading Joy for Pleasure: Porn's Impact00:51:02 - Money vs Power: The Dark Truth Behind Online Exploitation00:53:11 - Rebuilding Community Through Honest Conversations00:57:09 - Reconceptualizing Pornography as Public Health Crisis Hosted on Acast. See acast.com/privacy for more information.

I've started recommending microdosing GLP-1 peptides for their regenerative and healing properties.  And the cold, hard truth is: Peptides can do things that supplements can't.   Supplements have their place, but I'm sure you've seen a multitude of supplements claiming to “help your body produce more GLP-1 naturally.”  For most Americans, that's actually not helpful.  Their metabolisms are busted after years of high stress, constant abuse, autoimmune conditions, chronic inflammation, a dysregulated nervous system, and decades of Diet Trauma trying to just “eat less and exercise more.”   That's why I'm only recommending GLP-1 peptides if you truly want to heal your metabolism and lose weight for life.  I know it might feel more intimidating than a supplement, but I guarantee it's far more effective.  Keep listening and I'll show you why.  PS - I also share what supplements you should be taking while on a GLP-1 that will enhance your body's healing journey.  Ready to explore if peptides are the right fit for you?  Right now I'm only offering GLP-1 guidance when you work with me in a 6-month or 12-month coaching container. Join me in a membership style group, or for private coaching, and I'll walk with you every step of the way.  From dosing, to lifestyle changes, to emotional eating support, to that abusive co-parent who's driving you crazy, I've got you covered.  Schedule your free consultation to learn more:  www.bodyyoucrave.com/schedule Chapters (00:00:02) - Hungry for Love(00:00:24) - Proteins vs Supplements: What's The Difference?(00:09:15) - Supplements vs. Peptides: How They Compare(00:14:51) - Rebuilding the Metabolism with Supplements(00:22:26) - Trezepatide(00:27:31) - How to Break the Cycle

Gleb Zilberstein is my guest in this episode of the Physics World Weekly podcast. A physicist by training, Zilberstein applies the principles of proteomics to the study of historical objects including Renaissance manuscripts. He is also a director of Israel-based SpringStyle Tech Design, which has created a special film that lifts proteins from the surfaces of historical objects. Analysis of these proteins provides  important information about how those objects were used. In a recent paper, Zilberstein and colleagues studied protein residues on a well-thumbed book of medical recipes that was published in Germany in 1531. He explains how their analysis provides a new view into how medical practitioners used the book and what sorts of concoctions they were making. Astonishingly, the team found evidence that European readers had access to ingredients derived from hippopotamuses. Some papers about the application of proteomics to historical research: The Scientific Analysis of Renaissance Recipes Count Dracula Resurrected  EVA Technology and Proteomics: A Two-Pronged Attack on Cultural Heritage

Playtime Peril or Plush Potential: AI Toys Tangle with Toddlers' Trust.  Blaze-Busting Bot: Firefighting's Fearless Frontline Future.  Paw-sitively Perilous: AI Pet Scams Prey on Panic and Photos.  Gemini Gets Going: Google's Groundbreaking Grab at Gadget-Driven Tasking.  Bipedal Bots Bring Blue-Collar Boosts.  Vape Voltage Venture: From Trash to Torque on Tiny EV Streets.  Pokémon-Powered Paths: Pixelated Players Pave the Way for Pizza-Delivering Robots.  Paws, Proteins and Personalised Precision: AI-Powered Pet Vaccine Pioneers Cancer Cure.  Neo Notebook Nirvana: Apple's Budget Breakthrough Blows Up the Laptop Landscape. 

On this week's Technique of the Week we are getting into your freezer and you should too. What proteins are in your freezer? Check out your freezer and try these thaw methods. See omnystudio.com/listener for privacy information.

For the first time since Platts began tracking these markets, frozen boneless chicken legs shipped to North Asia are priced higher than skinless boneless breast meat destined for the Middle East. This shift highlights changing demand and supply dynamics in the global poultry market. The podcast explores the impact of bird flu, supply chain disruptions, and how producers like Brazil are adapting to consumer preferences. Join S&P Global Energy's Graham Style, price reporter for agriculture and food (EMEA), Rubashiny Veeramohan, associate price reporter for agriculture and food (APAC), and Jessie Khor, principal analyst for Proteins, as they discuss how global events and shifting demand are reshaping the poultry landscape.

In this episode of the Hormone Genius Podcast, we dive into the science behind protein, without getting lost in the intimidating biochemical diagrams. Instead, we take a practical and approachable look at what protein actually does in the body, why amino acids matter, and how much protein people really need to support optimal health. Proteins are literally the structural foundation of our bodies. They make up a significant portion of our tissues, including muscles, organs, skin, enzymes, hormones, and immune molecules. In fact, a large percentage of our body composition is made up of protein-based structures. Every cell in the body relies on proteins to function. That means every day our bodies must continually rebuild and repair protein structures just to maintain normal physiological balance. This process is known as anabolism, the state where the body is building and repairing tissues. The opposite state is catabolism, where tissues begin to break down. Ideally, our bodies maintain a balance between these two states. But if we don't consume enough protein, or if our bodies are under stress, illness, trauma, or aging—the body can shift toward catabolism. In that situation, it begins breaking down muscle tissue in order to release amino acids needed to sustain essential functions. One of the most common questions about protein is how much we should consume daily. You may have heard the popular recommendation of eating one gram of protein per pound of body weight. While this guideline is common in fitness communities, it may be unnecessarily high for many individuals. Current research from protein experts like Dr. Don Layman suggests that for most healthy adults who exercise moderately, a target of around: 0.7–0.8 grams of protein per pound of body weight may be sufficient to maintain muscle mass and support metabolic health. For many people, this translates to roughly 90–100 grams of protein per day. A simple strategy is to aim for 25–30 grams of protein per meal across three meals daily. This approach naturally distributes protein intake in a balanced way and supports consistent amino acid availability throughout the day. In other words, when the body doesn't receive enough protein from food, it may start consuming its own muscle to survive. This is one reason protein intake becomes increasingly important as we age. Sponsors

Longevity, Success, Healthy Living, and Nutrition Made Simple Join Our Health Club Community FREE https://www.drasa.com/health-club   Visit Us At Our Health Club Retreats https://www.drasa.com/retreats/ It's Dr. Asa Here... Ask Me Your Question! Text Me: 407-255-7076 Call Me: 888-283-7272

Protein engineering has traditionally been slow, expensive, and stuck in trial-and-error mode—but AI is changing everything. In this episode, we sit down with Elise De Reus, co-founder of Cradle Bio, to explore how generative AI is revolutionizing the way scientists design proteins for medicines, enzymes, and sustainable materials. Elise shares her journey from studying fungi and building high-throughput strain engineering systems at companies like Zymergen and Perfect Day, to creating an AI-powered platform that helps R&D teams generate better protein variants in less time and at lower cost. We discuss the massive design space of proteins, the role of machine learning in navigating that complexity, how Cradle balances computational predictions with biological reality, and what it will take for the bioeconomy to reach its trillion-dollar potential. Whether you're in pharma, industrial biotech, or just curious about the future of biology as a design problem, this conversation offers a fascinating look at how AI is becoming an essential tool for engineering the building blocks of life.Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and influencers changing the world by growing everything. Biology is the oldest technology. And it can be engineered. What are we growing?Learn more at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.messaginglab.com/groweverything⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Chapters:(00:00:00) - The AI Revolution Meets Biology(00:01:00) - Why Erum Switched from ChatGPT to Claude (And What It Means for AI)(00:03:00) - Lab-Grown Meat Just Got Real: The Breakthrough That Changes Everything(00:06:00) - The Roadmap to a Trillion-Dollar Bioeconomy: Inside the AB4S Report(00:08:00) - Proteins 101: The Molecular Machines Running Your Life(00:10:00) - From Studying Fungi to Building AI Tools: Elise De Reus's Origin Story(00:12:00) - Inside Cradle Bio: The AI Studio Transforming How Scientists Design Proteins(00:15:00) - The "Short, Fat Data" Problem: Why Protein Engineering Needs Different AI(00:18:00) - Finding Needles in Infinite Haystacks: How Generative AI Navigates Protein Space(00:23:00) - When AI Is Confident But Wrong: Balancing Predictions with Biological Reality(00:27:00) - Speed vs. Caution: Why Pharma and Industrial Biotech Innovate Differently(00:30:00) - The $500 Billion Question: What's Really Blocking the Bioeconomy?(00:35:00) - Success Stories: How AI Unstuck Projects That Were Going Nowhere(00:38:00) - Sequence vs. Structure: Which AI Models Win at Protein Design?(00:41:00) - The Future Is Here: Better Data, Faster DNA Assembly, and Smarter Tools(00:43:00) - Quick Fire: Elise's Hot Takes on Biotech's Biggest Questions(00:47:00) - Biology as a Design Problem: Why This Changes EverythingLinks and Resources:CradleTurning lab-grown yeast into edible scaffoldingSynBioBeta Pass - Discount code: Grow Everything 166. The Great Reformulation: Joshua Lachter Rethinks How We Make Everything at ScaleTopics Covered:protein design, protein engineering, biotech, lab automation, biomanufacturing. synthetic biology, AI drug discovery, directed evolution, biologics, computational biology, enzyme optimizationHave a question or comment? Message us here:Text or Call (804) 505-5553⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠Youtube⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠Grow Everything⁠⁠⁠⁠⁠Music by: Nihilore Production by: Amplafy Media

Hematologist-oncologist Khushali Jhaveri discusses her article "What the research really says about infrared saunas." Khushali shares her personal journey from skepticism to advocacy after experiencing the profound physiological shifts of infrared heat therapy. The conversation dives into the science of heat shock proteins, explaining how thermal stress helps the body repair cellular damage and manage inflammation. She reviews a landmark study from Finland showing massive reductions in cardiovascular mortality among frequent sauna users. Khushali also distinguishes between traditional and infrared saunas, noting that while the latter operate at lower temperatures, they offer similar benefits through passive heat exposure. Discover how this ancient practice might be a key to healthier aging and longevity. Partner with me on the KevinMD platform. With over three million monthly readers and half a million social media followers, I give you direct access to the doctors and patients who matter most. Whether you need a sponsored article, email campaign, video interview, or a spot right here on the podcast, I offer the trusted space your brand deserves to be heard. Let's work together to tell your story. PARTNER WITH KEVINMD → https://kevinmd.com/influencer SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

English Edition: Meet Thomas White from DESY (German Electron Synchrotron) who is the creator and maintainer of the tool CrystFEL. The tool to help understand and analyse the structure of materials such as crystals and proteins. Thomas and I dive into the details of the science and experimental setup - and, of course, the software tool he created. Links:https://en.wikipedia.org/wiki/X-ray_diffraction https://www.cfel.de https://www.desy.de/~twhite/crystfel/ https://www.ccp4.ac.uk https://vimeo.com/1017833941 https://en.wikipedia.org/wiki/Free-electron_laser https://en.wikipedia.org/wiki/Serial_femtosecond_crystallography Get in touchThank you for listening! Merci de votre écoute! Vielen Dank für´s Zuhören!Contact Details/ Coordonnées / Kontakt:Email mailto:peter@code4thought.orgUK RSE Slack (ukrse.slack.com): @code4thought or @piddie Bluesky: https://bsky.app/profile/code4thought.bsky.socialLinkedIn: https://www.linkedin.com/in/pweschmidt/  (personal Profile)LinkedIn: https://www.linkedin.com/company/codeforthought/ (Code for Thought Profile)This podcast is licensed under the Creative Commons Licence:  https://creativecommons.org/licenses/by-sa/4.0/

In this week's episode, Kacy and Tyler deep dive on protein powders and explain the differences between types and blends.

Longevity, Success, Healthy Living, and Nutrition Made Simple Join Our Health Club Community FREE https://www.drasa.com/health-club   Visit Us At Our Health Club Retreats https://www.drasa.com/retreats/ It's Dr. Asa Here... Ask Me Your Question! Text Me: 407-255-7076 Call Me: 888-283-7272

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In this episode of the Crazy Wisdom podcast, host Stewart Alsop sits down with Markus Buehler, the McAfee Professor of Engineering at MIT, to explore how seemingly different systems—from proteins and music to knowledge structures and AI reasoning—share underlying patterns through hierarchy, self-organization, and scale-free networks. The conversation ranges from the limits of current AI interpolation versus true discovery (using the fire-to-fusion example), to the emergence of agent swarms and their non-linear effects, to practical questions about ontologies, knowledge graphs, and whether humans will remain necessary in the creative discovery process. Markus discusses his lab's work automating scientific discovery through AI agents that can generate hypotheses, run simulations, and even retrain themselves, while Stewart shares his own experiences building applications with AI coding agents and grapples with questions about intellectual property, material science constraints, and the future of human creativity in an AI-abundant world.Timestamps00:00 - Introduction to Marcus Buehler's work on knowledge graphs, structural grammar across proteins, music, and AI reasoning05:00 - Discussion of AI discovery versus interpolation, using fire and fusion as examples of fundamental versus incremental innovation10:00 - Language models as connective glue between agents, enabling communication despite imperfect outputs and canonical averaging15:00 - Embodiment and agency in AI systems, creating adversarial agents that challenge theories and expand world models20:00 - Emergent properties in materials and AI, comparing dislocations in metals to behaviors in agent swarms25:00 - Human role-playing and phase separation in society, parallels to composite materials and heterogeneity30:00 - Physical world challenges, atom-by-atom manufacturing at MIT.nano, limitations of lithography machines35:00 - Synthetic biology as alternative to nanotechnology, programming microorganisms for materials discovery40:00 - Intellectual property debates, commodification of AI models, control layers more valuable than model architecture45:00 - Automation of ontologies, agent self-testing, daughter's coding success at age 1150:00 - Graph theory for knowledge compression, neurosymbolic approaches combining symbolic and neural methods55:00 - Nonlinear acceleration in AI, emergence from accumulated innovations, restaurant owner embracing AI01:00:00 - Future generations possibly rejecting AI, democratization of knowledge, social media as real-time scientific discourseKey Insights1. Universal Patterns Across Disciplines: Seemingly different systems in nature—proteins, music, social networks, and knowledge itself—share fundamental structural patterns including hierarchy, self-organization, and scale-free networks. This commonality allows creative thinkers to draw insights across disciplines, applying principles from one domain to solve problems in another. As an engineer and materials scientist, Buehler has leveraged these isomorphisms to advance scientific understanding by mapping the "plumbing" of different systems onto each other, revealing hidden relationships that enable extrapolation beyond what's observable in any single domain.2. The Discovery Versus Interpolation Problem: Current AI systems, particularly large language models, excel at interpolation—recombining existing knowledge in new ways—but struggle with genuine discovery that requires fundamental rewiring of world models. Using the example of fire versus fusion, Buehler explains that an AI trained on combustion chemistry would propose bigger fires or new fuels, but couldn't conceive of fusion because that requires stepping back to more fundamental physics. True discovery demands the ability to recognize when existing theories have boundaries and to develop entirely new frameworks, something current AI architectures aren't designed to achieve due to their training objective of predicting the most likely outcome.3. The Role of Ontologies and Knowledge Graphs: While some AI researchers argue that ontologies are unnecessary because models form internal representations, Buehler advocates for explicit knowledge graphs as essential discovery tools. External ontologies provide sharp, analytical, symbolic representations that complement the fuzzy internal representations of neural networks. They enable verification of rare connections—like obscure papers that might hold key insights—which would be averaged away in standard AI training. This neurosymbolic approach combines the generalization capabilities of neural networks with the precision of formal knowledge structures, creating more powerful discovery systems.4. Emergent Properties and Agent Swarms: Just as materials science shows that collections of atoms exhibit properties impossible to predict from individual components, AI agent swarms demonstrate emergent behaviors beyond single models. When agents are incentivized not just to answer questions but to challenge each other adversarially, propose theories, and test hypotheses, they can spawn new copies of themselves and evolve understanding beyond their initial programming. This emergence isn't surprising from a materials science perspective—dislocations, grain boundaries, and other collective phenomena only appear at scale, fundamentally determining material behavior in ways unpredictable from studying just a few atoms.5. The Commoditization of Intelligence: The fundamental AI models themselves are becoming commodities, as evidenced by events like the Moldbug phenomenon where people built agents using various providers interchangeably. The real value is shifting from who has the smartest model to how models are orchestrated, integrated, and deployed. This parallels historical technology adoption patterns—just as we moved past debating who makes the best electricity to focusing on applications, AI is transitioning from a horse race over model capabilities to questions of infrastructure, energy, access speed, and agent coordination at the systems level.6. Human-AI Collaboration and Creative Control: Rather than wholesale replacement, AI enables humans to operate in an intensely creative space as orchestrators sampling from vast possibility spaces. Similar to how Buehler's 11-year-old daughter now builds sophisticated applications that would have required professional developers years ago, AI democratizes access to capabilities while humans retain the creative judgment about direction and meaning. The human role becomes curating emergence, finding rare connections, playing at the edges of knowledge, and exercising the kind of curiosity-driven exploration that AI systems lack without embodied stakes in their own survival and continuation.7. Technology as Evolutionary Inevitability: The development of AI represents not an unnatural threat but the next stage of human evolution—an extension of our innate drive to build models of ourselves and our world. From cave paintings to partial differential equations to artificial intelligence, humans continuously create increasingly sophisticated representations and tools. Attempting to stop this technological evolution is futile; instead, the focus should be on steering it ...

Eva is an Associate Professor at the University of New England, where her research focuses on proteins and utilizes biochemistry, biomaterials, and biophysics. She is also deeply interested in antidisciplinary, collaborative research. Eva was a 5 Minute Genius™ speakers at the 2024 Maine Science Festival; you can see her talk on our YouTube channel. This conversation was recorded in December 2025. ~~~~~The Maine Science Podcast is a production of the Maine Discovery Museum. It is recorded at Discovery Studios, at the Maine Discovery Museum, in Bangor, ME. The Maine Science Podcast is hosted and executive produced by Kate Dickerson; edited and produced by Scott Loiselle. The Discover Maine theme was composed and performed by Nick Parker. To support our work: https://www.mainediscoverymuseum.org/donate. Find us online:Maine Discovery MuseumMaine Discovery Museum on social media: Facebook Instagram LinkedIn Bluesky YouTubeMaine Science Podcast on social media: Facebook Instagram YouTubeMaine Science Festival on social media: Facebook Instagram LinkedIn YouTube© 2026 Maine Discovery Museum

The p53 protein plays a central role in preventing cancer by responding to cellular stress and DNA damage. When activated, it can repair damaged DNA or trigger cell death, preventing the survival of potentially malignant cells. Loss of p53 function is a hallmark of many cancers. HPV is well known to inactivate p53 through its E6 protein, which promotes p53 degradation. This mechanism contributes to HPV-associated cancers, including cervical, anal, and head and neck cancers. SARS-CoV-2, while not traditionally classified as an oncogenic virus, has been shown to interfere with immune function and, in some cases, with cellular pathways that involve p53. A recent article by Dr. Wafik El-Deiry of The Warren Alpert Medical School of Brown University, published in Oncotarget, proposes a scientific hypothesis suggesting that proteins from HPV and SARS-CoV-2 may both interfere with the body's tumor-suppressing mechanisms, potentially compounding their effects on cancer-related pathways. The Hypothesis: HPV E6 and SARS-CoV-2 Spike Proteins May Cooperatively Suppress p53 In the paper, titled “Hypothesis: HPV E6 and COVID spike proteins cooperate in targeting tumor suppression by p53,” Dr. El-Deiry proposes that the SARS-CoV-2 spike protein, whether introduced via infection or mRNA vaccination, may suppress p53 activity in a manner that complements the effects of HPV E6. In individuals with persistent HPV infection, this combined interference could further reduce p53 function, weakening tumor suppression mechanisms. Full blog - https://www.oncotarget.org/2026/02/09/how-hpv-and-covid-19-spike-proteins-may-interact-to-impact-cancer-suppression/ Paper DOI - https://doi.org/10.18632/oncotarget.28823 Correspondence to - Wafik S. El-Deiry - wafik@brown.edu Abstract video - https://www.youtube.com/watch?v=2GJVmpG4fPk Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28823 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, HPV, COVID, p53, spike To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Fritz Family founder Cory Buenning brewed from the mid-90's through the mid 20-teens for Wyoming craft beer pioneers Snake River, but the itch to do his own thing was strong, and after returning to Colorado after a few years in Kentucky, he leased the old Bootstrap brewery in Niwot, installed a new brewhouse and cellar, and got to work making the beers he wanted to make—a variety of primarily lager beer, brewed thoughtfully and carefully. Years later, the brewery has developed a strong following among locals, but is also a favorite hangout for the area's brewers, and you'll often find brewers from neighboring breweries at the Fritz bar for a post-shift beer. It's brewers beer, after all—easy to drink, impeccably made, and unassuming. In this episode, Buenning shares his approach to making refined lagers at a taproom scale, and along the way discusses: how cold knockouts, cold fermentation, and no diacetyl rest make better lagers brewing with an jacketed oil-heated brewhouse rather than steam-heated acidifying the mash using sauergut building body in clear beer through proteins not carbohydrates carbonating naturally via capped tank using forced fermentation tests on all lagers managing gelatinization issues with European malt through modified step mashing ingredient approaches to Pilsner, helles, and Kölsch understanding yeast timing and performance to dial in harvesting and rep itching managing head pressure with 34/70 to reduce sulfur And more. G&D Chillers G&D's new Elite 290 Micro-series runs on a Natural Refrigerant with near-zero Global Warming Potential—built for brewers who care about sustainability and performance. They recently built one for New Belgium Brewing, delivering around 50% energy savings over CO₂ systems and 9% more efficiency than A2Ls. That's real-world impact from a brewery that knows what it takes. With 24/7 support and remote monitoring, your cold side stays dialed in—day or night. Learn more about sustainable chiller solutions at gdchillers.com. Berkeley Yeast Berkeley Yeast just launched Dry Tropics London! Our best-selling liquid yeast strain, now with all the ease-of-use benefits of dry yeast. Dry Tropics London delivers the soft, pillowy mouthfeel and juicy character you'd expect from a top-tier London Ale strain, but with a serious upgrade: a burst of thiols that unleash vibrant, layered notes of grapefruit and passion fruit. A lot of brewers love the clean passion fruit you get from Tropics, but they don't want every IPA to be a tropical-fruit bomb. At the dry yeast price point, you can pitch and ditch without breaking the bank. Or, you can co-pitch with your house strain to adjust the intensity of the notes. And with nationwide free shipping, there's never been a better time to try Dry Tropics. Order now at berkeleyyeast.com and experience the ease and impact of Dry Tropics London Yeast. PakTech This episode is sponsored by PakTech—delivering craft-beer multipacking you can trust. Our handles are made from 100 percent recycled plastic and are fully recyclable, helping breweries close the loop and advance the circular economy. With a minimalist design, durable functionality you can rely on, and custom color matching, our carriers help brands stand out while staying sustainable. Trusted by craft brewers nationwide, we offer a smarter, sustainable way to carry your beer. To learn more, visit paktech-opi.com. Indie Hops Strata Cryo The multilayered wonders of Indie Hops Strata are now easier than ever for brewers to tap into. Introducing Strata Cryo, in collaboration with Yakima Chief Hops. Whether brewing up a single-hop Strata IPA to wow customers with the depth of flavor this variety delivers or modernizing your flagship IPA to continue setting the highest standards, Strata T99, Strata CGX, Strata HyperBoost, and now Strata Cryo provide the tools for you to create your unique masterpiece. Indie Hops Strata. Life is short. Let's make it flavorful! Midea 50/50 Flex The Midea 50/50 flex is the industry's first dual compartment three-way convertible freezer. The 50/50 Flex is designed to flex with your life. It can convert to all fridge, all freezer, or half and half with just the touch of a button. Plus, with reversible doors and adjustable storage compartments, you can stay organized no matter your food-storage needs. The 50/50 Flex is also designed to maintain a stable temperature even in non-climate-controlled spaces. So it's perfect for your garage, man cave, or wherever you need a little more space. Maybe use all 20 cubic feet as a beer fridge! Check out Midea.com/us/ for more information on how to take your beer storage to the next level. Old Orchard If your brewery is using fruit juice concentrates, purees, and blends, then why not source everything from a one-stop shop? Old Orchard might be best-known for flavored blends, but if you need 100% purees or concentrates, then Old Orchard can likely help—even with options not listed on their website. Let Old Orchard know what you need at oldorchard.com/brewer. Brightly Software Brightly Software, a Siemens company, partners with organizations at every stage of their asset lifecycle journey. Brightly is a complete asset-management and operations software that enhances organizational sustainability, compliance, and efficiency through data-driven decision making. Streamline maintenance, simplify capital planning, and optimize resources with solutions uniquely designed to support long-term goals. Learn more at brightlysoftware.com. 2026 Brewers Retreat Tickets are on sale now for the annual Craft Beer & Brewing Brewers Retreat August 23–26 in the hop country of Yakima Valley, Washington. There's nothing like this fantasy homebrew-camp experience, as you brew in small groups led by some of the most inspiring brewers in the world—folks such as Vinnie and Natalie of Russian River, Ben from Breakside, Henry and Adriana of Monkish, Kelsey from North Park, Whitney from Grand Fir, Sean from Lawson's Finest, and more. This year we'll be brewing under the bines at Bale Breaker, and it's sure to be an unforgettable experience. Tickets are on sale now and going fast at brewersretreat.com.

The rapidly evolving field of protein design is revealing solutions to some of the world's greatest problems, whether it's blocking a virus, breaking down a pollutant or creating brand-new materials. In conversation with TED's Whitney Pennington Rodgers, biochemist David Baker explores his team's Nobel Prize-winning work using AI to design new proteins with functions never before seen in nature — achieving breakthroughs that have fundamentally changed the future of science. (This conversation was part of an exclusive TED Membership event. TED Membership is the best way to support and engage with the big ideas you love from TED. To learn more, visit ted.com/membership.)Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

BUFFALO, NY – January 13, 2026 – A new #hypothesis article was #published in Oncotarget (Volume 17) on January 3, 2026, titled “Hypothesis: HPV E6 and COVID spike proteins cooperate in targeting tumor suppression by p53.” Written by Wafik S. El-Deiry, Oncotarget Editor-in-Chief, from The Warren Alpert Medical School of Brown University and from Lifespan Health System and Brown University, the paper proposes that two viral proteins, HPV E6 and SARS-CoV-2 spike, could jointly reduce the activity of p53, a protein that helps protect cells from becoming cancerous. HPV is already known to drive several cancers, and the hypothesis suggests that additional pressure on p53 could matter for cancer risk or recurrence in some settings. HPV can promote cancer development in part by using its E6 protein, together with a human partner protein called E6-AP, to drive the downregulation of p53. When p53 is weakened, damaged cells may be more likely to survive and continue growing. The new hypothesis asks whether SARS-CoV-2 viral influence could further reduce p53 function in people already affected by HPV. The article highlights studies suggesting that the SARS-CoV-2 spike protein may suppress p53 activity and discusses observations that have raised questions about cancer outcomes after COVID-19 infection or vaccination in certain contexts. It also notes that a search of the literature did not identify clear evidence of direct molecular cooperation between HPV and COVID-19 in suppressing p53, which underscores the need for further studies. “I listened to an interview (https://www.youtube.com/watch?v=tnVMjp9mCA0&t=2s) of Dr. Patrick Soon-Shiong by Chris Cuomo where I learned about a patient named Jim Johnson with a history of HPV-related head and neck cancer who by 2022 had survived his HPV-related cancer for 7 years and then he took the COVID vaccine.” To investigate the presented hypothesis, Dr. El-Deiry proposes epidemiological studies that analyze cancer incidence and recurrence in HPV-positive groups with prior SARS-CoV-2 infection or COVID mRNA vaccination. It also proposes laboratory studies to assess whether HPV E6 and SARS-CoV-2 spike combined reduce p53 function more than either factor alone. Overall, the hypothesis was formulated to focus attention on an HPV and SARS-CoV-2 shared biological target, p53, and to encourage careful studies that separate coincidence from causation. By outlining specific approaches, it aims to help researchers evaluate whether combined viral pressures on tumor-suppressor pathways could contribute to cancer progression. DOI - https://doi.org/10.18632/oncotarget.28823 Correspondence to - Wafik S. El-Deiry - wafik@brown.edu Abstract video - https://www.youtube.com/watch?v=2GJVmpG4fPk Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28823 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, HPV, COVID, p53, spike To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Thank you for tuning in for another episode of Life's Best Medicine. To kick off the new year, let's talk about a very serious and, unfortunately, very controversial issue: Covid vaccine side-effects. This topic is too important to be ignored as there are many people out there who may be suffering from vaccine-related health problems without realizing it. In this episode, Dr. Brian talks about… (00:00) Intro (04:52) Long-term Covid vaccine side-effects (12:04) Kidney dysfunction due to increased spike protein production (13:34) What to do if you suspect you are suffering from Covid vaccine side-effects (18:13) Spike protein tests (21:07) Outro For more information, please see the links below. Thank you for listening!   Links:   Dr. Brian Lenzkes:  Arizona Metabolic Health: https://arizonametabolichealth.com/ Low Carb MD Podcast: https://www.lowcarbmd.com/   HLTH Code: HLTH Code Promo Code: METHEALTH • • HLTH Code Website: https://gethlth.com

In this episode, we review the high-yield topic of⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Cell Surface Proteins ⁠from the Biochemistry section.Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets

Dr. Randy Blakely is a Professor of Biomedical Science at Florida Atlantic University and Executive Director of the Florida Atlantic University Brain Institute. Randy is examining how neurons control neurotransmitter signaling, as well as how medicinal drugs and drugs of abuse impact neurotransmitters. He is interested in how normal neurotransmitter regulation and changes in neurotransmission due to drugs ultimately impact behavior. Randy lives in beautiful South Florida near the Everglades, and he likes to spend is free time enjoying nature and observing the local wildlife. While commuting between campuses, Randy listens to a variety of audiobooks, and he is also a big fan of Americana and folk music. He received his B.A. in Philosophy from Emory University and his Ph.D. in Neuroscience from the Johns Hopkins School of Medicine. He next conducted postdoctoral research at the Yale/Howard Hughes Medical Institute Center for Molecular Neuroscience. Randy was an investigator and faculty member at Emory University and Vanderbilt University before accepting his current position at Florida Atlantic University. Randy is the recipient of numerous awards and honors for his research and mentorship. He was awarded the Daniel Efron Award from the American College of Neuropsychopharmacology, two Distinguished Investigator Awards from the Brain and Behavioral Research Foundation, a MERIT Award from the National Institute of Mental Health, a Zenith Award from the Alzheimer's Association, the Delores C. Shockley Partnership Award in recognition of minority trainee mentorship, as well as the Astellas Award in Translational Pharmacology and the Julius Axelrod Award both from the American Society for Pharmacology and Experimental Therapeutics. In addition, he is a Fellow of the American Academy for the Advancement of Science. Randy joins us in this episode to talk more about his life and science.

This Thanksgiving episode of The Hen Report serves up a hearty helping of gratitude alongside meaningful animal advocacy discussions. Jasmin and Mariann reflect on the growth of Our Hen House, which now reaches thousands of listeners weekly through multiple podcast formats. The episode features producer Vicki Beechler’s thoughtful review of Kendra Coulter’s new novel “The Tortoise’s Tale,” a beautifully crafted story…

Proteins are crucial for life. They're made of amino acids that “fold” into millions of different shapes. And depending on their structure, they do radically different things in our cells. For a long time, predicting those shapes for research was considered a grand biological challenge.But in 2020, Google's AI lab DeepMind released Alphafold, a tool that was able to accurately predict many of the structures necessary for understanding biological mechanisms in a matter of minutes. In 2024, the Alphafold team was awarded a Nobel Prize in chemistry for the advance.Five years later after its release, Host Ira Flatow checks in on the state of that tech and how it's being used in health research with John Jumper, one of the lead scientists responsible for developing Alphafold.Guest: John Jumper, scientist at Google Deepmind and co-recipient of the 2024 Nobel Prize in chemistry.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Today, in association with Proteomics International, we're hearing about a new era in medicine where we can tell people not what diseases they've got, but what ones they will have in ten years' time, giving them a chance to turn things around... Like this podcast? Please help us by supporting the Naked Scientists

Can you actually detox spike proteins from your body after a viral infection?     On today's show, I break down how long spike proteins may remain in the body and why inflammation, preexisting health conditions, and mitochondrial stress often play a bigger role in post-viral symptoms than the proteins themselves.     I'll also share nutrients that appear to help support the body's natural detoxification and recovery process, including enzymes and compounds that aid in circulation, inflammation control, and immune balance, along with foundational immune support you can rely on.     Tune in to today's Cabral Concept 3548 to learn what the science really says and how to strengthen your body's natural defenses from the inside out.     Enjoy the show!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3548 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Episode Highlights With NathalieWhat the latest research is saying about peptides and what she's studying and tryingBioregulators and how they work so uniquely Peptides by definition are small proteins and often fragments of naturally occurring peptides in the bodyAbout 7,000 peptides have been identified Bioregulators are only 2-5 amino acids in lengthHer take on GLP-1s and important things to know if you try themWhat testing and data she looks at and considers most important Iron overload and why it isn't talked about muchBlood and microbiome testing and which ones are worth doingHer take on regenerative medicine and longevity Ovarian aging and how this ties to body agingResources MentionedFollow Nathalie on her website and on InstagramHer podcast Longevity with Nathalie Niddam Function Health 

Dr. Robert Lustig, a world-leading expert on sugar addiction, metabolism, ultra-processed food, and artificial sweeteners, reveals how they fuel obesity, dementia, dopamine overload, and addiction - and the dangers of RFK Jr.'s health approach. Dr. Robert Lustig is a neuroendocrinologist and expert on sugar, obesity, and the science of addiction, whose groundbreaking new research reveals how the 4 major health crises are all interconnected and driven by stress. He is also the bestselling author of books such as, ‘Metabolical', and ‘Fat Chance'.  He explains: ◼️Why 29% of Americans are depressed and how food plays a hidden role ◼️How 17 seconds of pleasure can rewire your brain for lifelong addiction ◼️How the food industry secretly engineers addiction and fuels chronic disease ◼️Why 95% of Alzheimer's risk is environmental and completely preventable ◼️The dangerous link between dopamine spikes and brain cell death (00:00) Intro (02:28) The Hostage Brain (06:24) Dopamine and the Pain of Lacking Control (09:32) Tolerance Is the Start of Addiction (10:39) If You Depend on Anything, It's Bad (11:25) Is Dopamine Fasting the Cure? (13:25) Can You Rewire Your Brain Away from Sugar Cravings? (15:15) The Shocking Link Between Dementia and Diet Products (22:39) Proteins (25:32) Is Alzheimer's Genetic or Environmental? (28:56) Ketones (33:08) Ultra-Processed Foods Are Poison (34:26) Reengineering Ultra-Processed Food to Be Healthy (39:41) What Needs to Change in the USA (45:06) RFK and Vaccination in the USA (51:56) Important Message About Where You Get Your Information (55:27) Ads (56:29) Practical Steps to Fix Your Addiction (01:01:24) If You Have an Inflamed Brain, You Can't Love (01:04:08) Are Our Diets Making Us Lonely? (01:08:03) Your Vagus Nerve Needs to Be Healthy (01:08:44) Do Vagus Nerve Stimulators Work? (01:10:53) The Real Truth About Ozempic (01:16:08) Can Ozempic Help with Addiction? (01:18:45) Practical Tips to Lose Weight and Eat Less Ultra-Processed Food (01:22:02) The Dangers of Drinking Soda (01:24:22) Younger People Are Getting Cancer More Than Ever (01:27:35) Ads (01:34:29) Does Exercise Help Lower Your Sugar Consumption? (01:36:27) Almost Half of the Population Is Pre-Diabetic (01:39:38) Glucose Monitors (01:41:58) Psychedelics Follow Dr Robert: Instagram - https://bit.ly/3KkR9ce  Website - https://bit.ly/48MtKdA  You can purchase Dr Robert's book, ‘Metabolical: The Lure and the Lies of Processed Food, Nutrition, and Modern Medicine', here: https://amzn.to/48Cme56 The Diary Of A CEO: ◼️Join DOAC circle here - https://doaccircle.com/  ◼️Buy The Diary Of A CEO book here - https://smarturl.it/DOACbook  ◼️The 1% Diary is back - limited time only: https://bit.ly/3YFbJbt  ◼️The Diary Of A CEO Conversation Cards (Second Edition): https://g2ul0.app.link/f31dsUttKKb  ◼️Get email updates - https://bit.ly/diary-of-a-ceo-yt  ◼️Follow Steven - https://g2ul0.app.link/gnGqL4IsKKb  Sponsors:  Pipedrive - http://pipedrive.com/CEO    Stan Store - https://stevenbartlett.stan.store for your 14-Day free trial

In this episode of the Dr. Gundry Podcast, I'm diving into the surprising truths about protein — from the hidden dangers in everyday choices to the underrated sources that could actually help repair your gut, fuel your energy, and keep your brain sharp.Whether you want to feel stronger, support your digestion, or simply make smarter food choices, this episode will change the way you think about protein.For full show notes and transcript: https://drgundry.com/healthiest-protein-optionsThank you to our sponsors! Check them out: Get convenient, high-quality, and affordable groceries delivered with Thrive Market. Get $80 in free groceries at thrivemarket.com/gundrypodcast.For all your blue-light and EMF-blocking accessories, go to boncharge.com/GUNDRY and use the coupon code GUNDRY to save 15% off your entire order.Visit Juvent.com/GUNDRY and use code GUNDRY at checkout to get an extra $300 off your Juvent Micro-Impact Platform. Get a quote today at Progressive.com.Make the swap to non-toxic cookware. Get 10% off sitewide on nontoxic cookware at fromourplace.com using the code GUNDRY.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The rapidly evolving field of protein design is revealing solutions to some of the world's greatest problems, whether it's blocking a virus, breaking down a pollutant or creating brand-new materials. In conversation with TED's Whitney Pennington Rodgers, biochemist David Baker explores his team's Nobel Prize-winning work using AI to design new proteins with functions never before seen in nature — achieving breakthroughs that have fundamentally changed the future of science. (This conversation was part of an exclusive TED Membership event. TED Membership is the best way to support and engage with the big ideas you love from TED. To learn more, visit ted.com/membership.)For a chance to give your own TED Talk, fill out the Idea Search Application: ted.com/ideasearch.Interested in learning more about upcoming TED events? Follow these links:TEDNext: ted.com/futureyouTEDSports: ted.com/sportsTEDAI Vienna: ted.com/ai-vienna Hosted on Acast. See acast.com/privacy for more information.