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This is the "all-english"-version of the filaria-episode: Pestpodden presents a tropical topic that many of us struggle with understanding: filarial nematodes. Professor Mark Taylor - one of the worlds leading experts on filarial nematodes - guides us through this difficult topic - and presents some breaking research-news at the end of the episode. Hosted on Acast. See acast.com/privacy for more information.
Early in his studies, Nils Pilotte realized he wanted to pursue research with direct human applications and neglected tropical diseases fit that bill. This podcast explores this sorely-needed research and ways scientists like Nils Pilotte are making a difference. Listen and learn How soil-transmitted helminths steal nutrition from their human host, How Lymphatic filariases position themselves to block the lymphatic system, causing damaging elephantiasis, and What exciting molecular diagnostic techniques are in the works, like testing mosquito feces rather than mosquitos themselves. Nils Pilotte is a postdoctoral researcher with the Williams' Lab at Smith College. He works primarily in diagnostic methods in parasitology and focuses on filarial worms and soil-transmitted helminths diagnosis in particular. These worms cause devastating health issues in underserved communities and he works not only to eradicate infestations now but also prevent future resurgences. He gives the podcast audience a solid background on how both soil-transmitted helminths and filarial worms, which are transmitted by insect vectors, progress through life cycles via complex host relationships. Filarial worms, for example, must utilize two animal hosts to realize their adult reproduction stage. He treats listeners with his enthusiasm for studying this coevolution, speculating on the amazing science behind their adaptations. But this coevolution is more than just interesting. Researching the signaling between pathogen and host is key to developing methods for diagnosis of parasitic infections. "Cross-talk" is a phrase scientists use for this exchange. Because parasites developed clever ways to disguise themselves, understanding this cross-talk is at the forefront of understanding pathogenicity. Dr. Pilotte addresses various ways they are looking at this signaling that might aid better diagnostics. He also addresses ways he and others work to make diagnostics less expensive and more accessible. For example, he's working on a method to increase their testing of mosquito infection by testing their excreta, or feces, for the presence of pathogen material. It's much easier and simpler to collect the mosquito feces than the mosquitoes themselves. Listen in for more smart advances scientists are using to make the world healthier. For more about Nils Pilotte, see his researchgate page or search for him in Google scholar. Available on Apple Podcasts: apple.co/2Os0myK
Filarial worms are long thread like worms that live in the tissue and body cavities of vertebrates. Their eggs mature into tiny larvae called microfilariae. There are at least eight filarids that are of importance to humans and today we'll be talking about two of them—Wuchereria bancrofti and Brugia malayi. Joining me to discuss filariasis is parasitologist and author, Rosemary Drisdelle.
Filarial worms are long thread like worms that live in the tissue and body cavities of vertebrates. Their eggs mature into tiny larvae called microfilariae. There are at least eight filarids that are of importance to humans and today we’ll be talking about two of them—Wuchereria bancrofti and Brugia malayi. Joining me to discuss filariasis […] The post Filariasis: Wuchereria bancrofti and Brugia malayi appeared first on Outbreak News Today.
Vincent, Dickson, and Daniel discuss how filarial infection modulates the immune response to mycobacterial infection, and reveal a new case study. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Filarial infection modulate immune response (J Immunol) Memory T cells (Wikipedia) Image: Loa loa microfilaria Letters read on TWiP 86 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email
Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson discuss loaiasis caused by the filarial nematode Loa loa. Right-click to download TWiP #40 (52 MB .mp3, 73 minutes). Links for this episode: Albendazole therapy for US-bound refugees (NEJM) Microfilaria of Loa loa (png) Loa loa life cycle (png) Letters read on TWiP 40 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv.
Vincent and Dickson discuss the life cycle and pathogenesis of Dracunculus medinensis, the filarial nematode that causes dracunculiasis, or Guinea worm disease. Links for this episode: Dracunculus emerging from foot (jpg) Dracunculus medinensis life cycle (jpg) Guinea worm - WHO Guinea worm eradication - The Carter Center War against Guinea worm (YouTube) Caduceus vs staff of Asclepius Vincent and Dickson - the dogs (jpg) Letters read on TWiP 37
Vincent and Dickson discuss the life cycle and pathogenesis of Onchocerca volvulus, the vector-borne filarial nematode parasite that causes onchocerciasis, or river blindness.
Diseases caused by parasitic worms are a common problem in humans and animals, especially in the developing world. Here Dr Rachel Lawrence describes how filarial infections occur and manage to evade the immune response of the host.
Background: As international travel increases, there is rising exposure to many pathogens not traditionally encountered in the resource-rich countries of the world. Filarial infections, a great problem throughout the tropics and subtropics, are relatively rare among travelers even to filaria-endemic regions of the world. The GeoSentinel Surveillance Network, a global network of medicine/travel clinics, was established in 1995 to detect morbidity trends among travelers. Principal Findings: We examined data from the GeoSentinel database to determine demographic and travel characteristics associated with filaria acquisition and to understand the differences in clinical presentation between nonendemic visitors and those born in filaria-endemic regions of the world. Filarial infections comprised 0.62% (n = 271) of all medical conditions reported to the GeoSentinel Network from travelers; 37% of patients were diagnosed with Onchocerca volvulus, 25% were infected with Loa loa, and another 25% were diagnosed with Wuchereria bancrofti. Most infections were reported from immigrants and from those immigrants returning to their county of origin ( those visiting friends and relatives); the majority of filarial infections were acquired in sub-Saharan Africa. Among the patients who were natives of filaria-nonendemic regions, 70.6% acquired their filarial infection with exposure greater than 1 month. Moreover, nonendemic visitors to filaria-endemic regions were more likely to present to GeoSentinel sites with clinically symptomatic conditions compared with those who had lifelong exposure. Significance: Codifying the filarial infections presenting to the GeoSentinel Surveillance Network has provided insights into the clinical differences seen among filaria-infected expatriates and those from endemic regions and demonstrated that O. volvulus infection can be acquired with short-term travel.