Podcasts about immune

In this episode, Dr. David Jockers breaks down the surprising warning signs of a zinc deficiency, a problem that affects an estimated 25% of the world's population, and likely far more since so few people ever get tested. You will learn what zinc actually does in your body, from powering the zinc finger proteins that support healthy DNA expression to producing superoxide dismutase (SOD) and stopping viral replication, plus the key symptoms that show up when you run low: loss of taste and smell, brain fog and mood issues, thyroid problems, hair loss and premature graying, low libido, white spots on your nails, and frequent infections. Dr. Jockers also covers the hidden root causes that drain your zinc, including blood sugar swings, low stomach acid, excess copper and heavy metals, chronic stress, and common medications, along with the ideal zinc-to-copper ratio on labs, how much zinc to supplement, the best food sources, and his favorite form of zinc. In This Episode:  00:00 Libido Warning Sign 00:24 Podcast Intro And Labs 03:08 Zinc Deficiency Overview 03:56 What Zinc Does 05:41 Key Deficiency Symptoms 08:53 Root Causes Of Low Zinc 12:32 More Causes Stress Meds 13:29 Testing Zinc Copper Ratio 14:38 Supplement Dosing Tips 15:25 Best Food Sources 17:32 Zinc Forms And Glycine 18:02 Wrap Up And Next Steps   Glutathione is your body's master antioxidant, protecting your cells from oxidative stress and supporting your natural detoxification pathways, but the way you take it really matters. That's why I was so intrigued by the glutathione spray from Purality Health: you simply spray it on your tongue, it tastes great, and it's formulated with their advanced delivery technology plus added vitamin C. Go to masterantioxidant.com/drj for a buy one, get one free special, backed by a 180-day money-back guarantee. Too many people walk out of their annual checkup being told everything is fine, while early warning signs quietly go unnoticed. That's why I recommend SuperPower, a membership that tests 150+ biomarkers every year across a baseline and a progress test, covering your heart, liver, thyroid, hormones, metabolism, vitamin and mineral levels, gut microbiome, and even environmental toxins. Go to superpower.com and use code JOCKERS for $50 off your SuperPower membership.   "If you're dealing with an autoimmune or chronic inflammatory condition, you really have to look at your zinc levels." ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit masterantioxidant.com/drj to get a buy one, get one free special on Purality Health's glutathione spray Visit superpower.com and use code JOCKERS to get $50 off your SuperPower membership Email info@drjockers.com to test your zinc-to-copper ratio or work with one of our health coaches to analyze your labs Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

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In this special Beyond Lab Walls video podcast episode—part of the Salk Institute's 2026 Year of Brain Health—Salk President Gerald Joyce, MD, PhD, sits down with Janelle Ayres, PhD, an expert on how the immune system helps the body maintain balance, recover from stress, and stay resilient across a lifetime.

You grind your teeth at night. You bloat after a glass of water. You crave sugar and salt, you are wide awake at 2am, and your labs still come back fine. What if some of that is not your thyroid? Hashimoto's is two things and not one. Medication helps the thyroid side. The immune side is the part that is yours to work on, and part of that work is looking at what else your body is carrying. In episode 219, Kim Rogers (the Worm Queen) teaches you all about parasites and Hashimoto's. If you're curious but nervous (or grossed out,) this episode breaks down symptoms to watch for, how the kit works, and easy steps to get started.   RESOURCES MENTIONED Rogers Hood (the Parify cleanse kit and the lymph kit) I'm an affiliate for Rogers Hood, which means I earn a commission if you buy through my link. My listeners get 10% off with the code below. Code: HWH https://rogershood.com/ref/3790/ Beautifully Balanced Wellness castor oil The organic, cold pressed castor oil Kim uses, including her thyroid castor oil pack. https://beautifullybalancedwellness.store/collections/all Thyro Light red light device Kim mentioned using red light with castor oil. The red light I use and recommend has four wavelengths. Use my affiliate code to save $10: esther-yunkin-434010 https://www.restartmed.com/shop-thyroid-devices/?sld=hwh   NEW HERE? START HERE. New to the podcast? Start with the free guide, 10 Questions to Ask Your Doctor. https://health-with-hashimotos.kit.com/10-questions READY TO SORT YOUR HASHIMOTO'S? Hashimoto's Decoded: Thyroid or Immune walks you through sorting everything into thyroid or immune, in under an hour, with a workbook to help you figure out your next step. https://healthwithhashimotos.com/hashimotos-decoded/ JOIN THE HEALTH WITH HASHIMOTO'S COMMUNITY Join the free Health with Hashimoto's community on Skool. It's a supportive space for women navigating Hashimoto's, and it's free to join. https://www.skool.com/health-with-hashimotos/about Find all my other resources, including products and supplements I recommend, on my resource page: https://healthwithhashimotos.com/resources/ ABOUT THE PODCAST & ESTHER The Health with Hashimoto's podcast helps you sort your Hashimoto's into thyroid or immune, so you can finally understand what's happening in your body and what to do about it. Hosted by Esther Yunkin, a registered nurse and holistic health educator with 25 years of nursing experience. This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure, or prevent any disease.

Cameron Turtle, CEO of Waltham, Mass.-based Spyre Therapeutics, on developing long-lasting antibodies for immune disorders.

Tanya Mayadas joins Immune to talk about her road to study neutrophils and her research findings on neutrophil antigen presentation and novel neutrophil targeting therapies. Host: Cindy Leifer Guest: Tanya Mayadas Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Tanya recently appointed department chair and director Neutrophils, von Willebrand factor and P-selectin (Cell, 1991) P-selectin knockout mouse (Cell, 1993) Neutrophils as antigen presenting cells in cancer (Nat Comm, 2021) Neutrophils elicit broad anti-tumor immunity (Cancer Res Comm, 2026) FcR-mediated neutrophil recruitment (Circulation, 2009) Neutrophil classification and heterogeneity (Immunity, 2025) Neutrophils in Lupus (Curr Op Rheumatol, 2019) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

In this super-fascinating episode, Amit and Jeff interview Dr. Tom Buchheit: anesthesiologist, pain physician, scientist and regenerative medicine specialist. Tom takes us through the current thinking on the beneficial role of immune stimulation in healing musculoskeletal and neural tissues, teaches us about how he uses autologous conditioned serum, platelet-rich plasma, stem cell therapy and nerve hydrodissection to help patients in his clinic. It's a deep-dive into a growing and exciting field that many of us will experience, on one side of the needle or the other. 

What happens when a former college athlete and self-described skeptic slowly becomes a biohacker? In this episode, Renee sits down with her husband Ryan to unpack his evolution from late nights, drinking, and little focus on recovery to prioritizing sleep, nutrition, longevity, and health optimization.Ryan shares the biohacks and tools that have made the biggest difference for him, from wearables and meditation to nootropics, peptides, and IV therapy. They also dive into the realities of navigating health changes as a couple, why trust and patience matter, and how to optimize your health without losing the fun and spontaneity of life.SHOW NOTES:0:38 Welcome to the podcast!2:42 How Renee & Ryan met3:29 His habits as a college baseball player5:50 Resilience in your 20s7:32 Poker community8:35 Readiness vs Performance10:28 His reflection on health in his 20s13:53 Immune challenges15:23 Is it woo-woo?16:30 Muse for athletic performance19:01 Nootropics for poker20:25 OURA Ring feedback21:54 Infrared sauna24:00 The cost of getting sick25:45 Nicotine benefits & downsides29:47 Peptide turning point34:11 Trust vs resistance in health partnership37:55 Late-night snacking39:40 Balancing living life with being healthy42:52 Living to 15645:55 His final piece of advice47:53 Thanks for tuning in!RESOURCES:Muse headbandOURA RingPeptides:BioLongevity Labs - code: BIOHACKERBABESEllieMDNootropics:Nootopia - code: BIOHACKERBABESThesis Troscriptions - Methylene BlueLucy Nicotine Advertising Inquiries: https://redcircle.com/brands

Lactoferrin – A Miracle Molecule! And don't miss the following topics that Terry will also discuss on this show: Shingles and Dementia Nutrient of the Day: Vitamin E Mediterranean Meal versus McDonalds's: the Effect of Red Wine How to Fight Seasonal Depression

In this episode of ASTCT Talks, host Terri Lynn Shigle, PharmD, BCOP, clinical pharmacy specialist with Stem Cell Transplantation and Cellular Therapy Department at The University of Texas MD Anderson Cancer Center and current ASTCT director of pharmacists (ex-officio) and Mark Hamilton, MD, of The University of Texas MD Anderson Cancer Center discuss immune effector cell-associated enterocolitis (IEC-EC), a rare but potentially severe late complication of BCMA-directed CAR T-cell therapy. As the use of CAR T-cell therapies continues to expand, understanding and managing delayed toxicities has become increasingly important.The discussion highlights:The clinical presentation, incidence, and risk factors associated with IEC-EC.Current approaches to diagnosis, including endoscopy, pathology evaluation, and detection of CAR T-cell infiltration in the gastrointestinal tract.Emerging insights into the biology of IEC-EC and the role of persistent CAR T cells.Treatment strategies, supportive care considerations, and areas of ongoing research.This episode provides valuable clinical and translational perspectives on a rare but important CAR T-cell-related toxicity and explores how ongoing research may help improve diagnosis, management, and patient outcomes.Listen to the episode below or on your favorite app. Subscribe to ASTCT Talks and share this episode with your colleagues to keep the conversation going.This episode was made possible through support from Johnson & Johnson.

Since the Crack Daddy is an expert in basement waterproofing, one might imagine that water is just too afraid of him and will take its menace to a less capable victim, right? Wrong. In this episode, Adam reveals his own battle with water leaking in his finished basement.

Immune boosting herbs are popular, and it's not hard to see why. Everyone wants to avoid getting sick! It makes intuitive sense to a lot of folks that if you amp up your immunity, you'll be more resilient in the face of germs – or I guess, more resilient to germs in your face! But hang on. What does “immune boosting” even mean? Is immunity really a singular ‘thing' that can be stimulated, like sliding a dimmer switch upwards? Is it all just a matter of stimulating white blood cell activity? As is always the case in biology and medicine, the truth is more complicated than that.This is particularly relevant in the context of autoimmunity, where some of the so-called “immune boosting herbs” can actually have adverse effects. If you overstimulate an immune system that's attacking your own body, you just intensify the attack. So the question arises: what can a person with an autoimmune condition do to keep their defenses up? If we can't stimulate immunity, what can we do?The answer is: a lot. And it's all stuff that anyone can do, whether autoimmune or not. In our experience, it's also a lot more important than the immune stimulant herbs, because it's more foundational and more individualized than the “elderberry & echinacea for everyone!” one-size-fits-all approach.We can start by changing our focus from immune stimulation to immune modulation. This isn't just wordplay. Modulation of immunity means making multiple simultaneous adjustment in multiple directions, whereas stimulation is ALL AHEAD FORWARD. True immunity is a complex interplay of multiple organs, cell types, and signaling molecules in the body. Dialing everything up to 11 isn't constructive, but a strategic nudge in the right direction at the right time? That gets the job done, and immunomodulating herbs – like mushrooms and seaweeds – can do exactly that.Immunity is often discussed in martial metaphors: the pathogenic assault, the immune defenses, the combat between them. But if we follow this metaphor all the way, we should realize that logistics and supply lines are often what makes the difference in a real-world conflict, and this is no less true in our bodies. Lymphatics, nutritives, and sleep aid herbs can be much more helpful than immune-boosting herbs for this reason.The best defense is… a good defense, actually. Better to keep the germs out than to let them in, let them proliferate, and then get your guns blazing. Maintaining healthy boundaries, quite literally, is a key strategy. These are your points of contact with the outside world: your sinuses, your lungs, your GI tract. And even if you're autoimmune, you can work with demulcents, astringents, and vulneraries to keep their membranes functioning well.Our brand-new Winter Health bundle is the best way to go deeper in this material – and there's a lot further to go. (Yeah, this 90-minute episode is just an introduction to immunity and herbalism!) The bundle includes our Immune Health and Respiratory Health courses, and you get them at 40% off their standard pricing, a savings of $260. Learn everything you need to know to keep yourself & your family healthy and strong all winter long.Like everything we offer, these are self-paced online video courses. They come with lifetime access to current & future course material, the twice-weekly live Q&A sessions with us, open discussion threads integrated in each lesson, an active student community, study guides, quizzes & capstone assignments, and more!If you enjoyed the episode, it helps us a lot if you subscribe, rate, & review our podcast wherever you listen. This helps others find us more easily. Thank you!Our theme music is “Wings” by Nicolai Heidlas.Support the showYou can find all of our online herbalism courses at online.commonwealthherbs.com!

Your blood sugar isn't just about sugar — it's tangled up with your gut, your immune system, and how your whole metabolism runs. This episode pulls together three conversations that build on each other, from one guy's simple fix to the bigger picture behind it all — meet your three experts below. Most people with type 2 diabetes are told it's a forever sentence. Chris Reade was one of them. In 2017, his A1C hit 9.1 with zero warning. He refused medication, did the research, and built a food system around the science of soluble fiber. Six months later, his A1C was 5.5. Seven years later, it has never gone back up. Danielle Hamilton is a Functional Nutritional Therapy Practitioner & Restorative Wellness Practitioner who specializes in blood sugar regulation & digestion. She became interested in blood sugar issues when she learned that Insulin Resistance was at the root of her PCOS. She was able to reverse her PCOS, cystic acne, PMS & weight loss resistance by reversing Insulin Resistance. Joel Greene is the very first gut-health protocol teacher, the original biohacker that utilizes the immune system and the family of insulin hormones to create lasting health. Joel has spoken on other top podcasts such as Ben Greenfield's Life and Cynthia Thurlow's Everyday Wellness.  In this episode, you'll hear three experts connect the dots between blood sugar, gut health, and metabolism — starting with one guy's simple fix and ending with the bigger picture behind it all. RESOURCES: Learn more about Chris Reade here: https://www.beatingdiabetes.us/ Chris Reade's Instagram: @beatingdiabetesus Check out the full conversation with Chris here: https://www.taragarrison.com/blog/chrisreade  Learn more about Danielle here: http://daniellehamiltonhealth.com Danielle Hamilton's Instagram: @daniellehamiltonhealth Check out the full conversation with Danielle here: https://www.taragarrison.com/blog/daniellehamilton Joel Greene's Instagram: @realjoelgreene Check out the full conversation with Joel here: https://www.taragarrison.com/blog/joelgreene   CHAPTERS: 00:00 – Intro: the blood sugar & metabolic health expert stack 01:39 – Chris on his diabetes diagnosis 03:46 – The shock: A1C jumps from normal to 9.3 06:04 – What caused it: a parasite that wrecked his gut biome 09:53 – The research: soluble fiber studies since the 1970s 12:33 – Cutting sugar, ramping fiber, and an unplanned 25-lb loss 14:35 – Danielle's wake-up call: the PCOS/diabetes connection 16:05 – The "personality traits" that were really blood sugar crashes 17:00 – Recognizing a crash: brain fog, mood, the Snickers test 22:14 – How blood sugar works and the insulin resistance spiral 27:05 – Digestion mechanics: chewing and stomach acid 31:01 – Bile, fat digestion, leaky gut, and practical fixes 34:37 – Joel's framework: three metabolisms, not one 36:04 – Immune cell metabolism's link to fat, obesity, and cancer 38:28 – Why sugar isn't "just a calorie": Warburg metabolism 42:40 – The gut-immune axis: your body's biggest immune hotspot 44:46 – Bifidobacteria and Akkermansia: the gut-immune balance 48:18 – Sugar, extreme diets, and why they backfire long term   WORK WITH TARA: Are You Looking for Help on Your Wellness Journey? Here's how Tara can help you: CHECK OUT HIGHER FITNESS APP: https://app.taragarrison.com/ INDIVIDUAL ONLINE COACHING: https://www.taragarrison.com/work-with-me CHECK OUT HIGHER RETREATS: https://www.taragarrison.com/retreats   SOCIAL MEDIA:  Instagram @coachtaragarrison TikTok @coachtaragarrison Facebook @coachtaragarrison Pinterest @coachtaragarrison   INSIDE OUT HEALTH PODCAST SPECIAL OFFERS: ☑️ Upgraded Formulas Hair Test Kit Special Offer: https://bit.ly/3YdMn4Z ☑️ Upgraded Formulas - Get 15% OFF Everything with Coupon Code INSIDEOUT15: https://upgradedformulas.com/INSIDEOUT15 ☑️ Rep Provisions: Vote for the future of food with your dollar! And enjoy a 15% discount while you're at it with Coupon Code COACHTARA: https://bit.ly/3dD4ZSv   If you loved this episode, please leave a review! Here's how to do it on Apple Podcasts: Go to Inside Out Health Podcast page: https://podcasts.apple.com/us/podcast/inside-out-health-with-coach-tara-garrison/id1468368093 Scroll down to the 'Ratings & Reviews' section. Tap 'Write a Review' (you may be prompted to log in with your Apple ID). Thank you!

"Unlike our cancer indications where we use these medications often to activate the immune system to target cancerous cells, in noncancer indications, the goal is really to either suppress an overactive immune or inflammatory cells or modulate the immune system. Immune modulation by use of chemotherapy and immunotherapy can help reduce abnormal inflammation, decrease autoantibody production, and also can alter T-cell and B-cell activity," ONS member Kelsey Miller, MSN, RN, AGCNS-BC, OCN®, clinical nurse specialist in oncology and infusion therapy at Reading Hospital in West Reading, PA, told Lenise Taylor, MN, RN, AOCNS®, TCTCN™, oncology clinical specialist at ONS, during a conversation about chemotherapy and immunotherapy for noncancer indications. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0  Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by September 18, 2027. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge related to the use of anticancer therapies for noncancer indications. Episode Notes  Complete this evaluation for free NCPD.  ONS Podcast™ episodes: Pharmacology 101 series Episode 152: Administer Rituximab Immunotherapy With Confidence ONS Voice articles: JAK1 Inhibitor Quickly Relieves ICI-Related Dermatitis Oncology Drug Reference Sheet: Cyclophosphamide Oncology Drug Reference Sheet: Methotrexate What Oncology Nurses Need to Know About Arboviral Disease in Patients Receiving B-Cell–Depleting or –Modulating Therapies ONS books: Access Device Guidelines: Recommendations for Nursing Practice and Education (fourth edition) Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice (second edition) Clinical Guide to Antineoplastic Therapy: A Chemotherapy Handbook (fourth edition) Clinical Journal of Oncology Nursing article: Early Recognition and Response of Chemotherapy-Induced Hypersensitivity Reactions: A Nursing Discussion ONS courses: ONS Fundamentals of Chemotherapy and Immunotherapy Administration™ Safe Handling Basics Vascular Access Devices ONS Huddle Cards: Anaphylaxis Monoclonal Antibodies ONS position statement: Education of the Nurse Who Administers and Cares for the Individual Receiving Antineoplastic Therapies American Academy of Neurology: Practice Guideline Recommendations: Disease-Modifying Therapies for Adults With Multiple Sclerosis American College of Rheumatology: Treatments National Multiple Sclerosis Society: Infused therapies Injectable therapies Medications Used Off-Label NCODA Patient Education Sheets To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "The most common immunotherapy agent that's well known to both oncology and other autoimmune disorders is rituximab. And that is used for rheumatoid arthritis, granulomatous, and antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis. And then it also has many off-label indications for other autoimmune disorders, such as lupus and multiple sclerosis. It's also used in immune thrombocytopenia and Sjogren's condition." TS 3:28 "Two common chemotherapy agents that come to mind that are used in lower doses for noncancer conditions are methotrexate, which helps modify the underlying disease process to reduce inflammation and preserve organ and joint function. And that's most commonly used rheumatology-wise first-line for rheumatoid arthritis and psoriatic arthritis. A second chemotherapy agent that's well known to oncology is cyclophosphamide, and that really serves as a powerful immunosuppressant for conditions such as ANCA-associated vasculitis and severe lupus nephritis." TS 3:57 "When talking about the monoclonal antibody frequency, it's often shorter in our oncology indications. We may see it weekly, every 21 days, every 28 days—compared to our autoimmune disorders that are months in between. This is really due to cancer cells continuously proliferating, so we need to stop the growth and not allow residual cancer cells to remain. And for the monoclonal antibodies, for example, rituximab again, it's depleting B cells that contribute to autoantibody production and inflammation. So targeting that after one to two infusions, the peripheral B cells are often depleted within days to weeks because of how well the drug works, how targeted it is. Those effects may persist for 6–12 months or even longer." TS 8:39 "Infection prevention education—it's so important to get to know the patient to individualize your teaching. For example, you need to know what matters most of the patients when they go home. Are they taking care of their grandchildren? Do they love to go outside and garden and do mulching? Are they cleaning up their chicken coop? So those kind of things, as a nurse, you can then help tailor your education so you can help prevent infection in these patients because I don't think just standard run-of-the-mill infection prevention teaching is as beneficial as when you can individualize it for that patient." TS 17:33 "If organizations are going to allow non-oncology nurses to administer, we just want to make sure that there is an established process or a protocol to administer rescue medications. That may include what you're already doing if you have a change in patient condition—calling for activating that emergency response system if you're in an inpatient setting. When we look at our ambulatory infusion centers that may have non-oncology nurses administering, you still have to have that training and competency verification and also emergency medical equipment readily available. That would include oxygen and your rescue medications. For the non-oncology nurse, some key points are to make sure that you check on your patient throughout these infusions and have that conversation up front to report any symptoms, both big and small." TS 23:06 "For safe handling, there are many misconceptions that it differs between cancer and non-cancer. When I first started at our organization, even some providers may minimize the risk for low-dose oral chemotherapy. However, it's still metabolized and excreted through our bodily fluids. And we know that traditional chemotherapy, like methotrexate and cyclophosphamide, is cytotoxic. So if a patient's prescribed them for noncancer indications, you still need to cover the basics, like shared bathrooms, what to do if there's contaminated linen, and also bring up the topic of contraception to ensure that our patients and their partners remain safe and do not get exposed." TS 27:13

A research paper recently published in Aging, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging,” investigated how a human-relevant mutation in the PTPN6 gene, which encodes the immune and metabolic regulator SHP-1, affects immune and liver function during aging. Using mice carrying the mutation, the researchers found that older mutant mice had improved glucose tolerance and hepatic insulin sensitivity, but also developed liver abnormalities characterized by increased fibrosis and the accumulation of immune cells, particularly B lymphocytes and macrophages. Further analyses indicated that these age-related changes were driven primarily by altered immune activity rather than direct effects within liver cells. The findings identify SHP-1 as an important regulator of liver immune homeostasis and provide new insight into how immune-cell infiltration may contribute to age-related changes in the liver. DOI - https://doi.org/10.18632/aging.206413 Corresponding author - André Marette - andre.marette@criucpq.ulaval.ca Abstract video - https://www.youtube.com/watch?v=lyn__UY9Buk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206413 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, SHP-1/Ptpn6, B cell, macrophage, aging, Ptpn6Ala457Thr To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Seth Andrews addresses an often unpopular reality: We're all human, and humans can be fooled. Check out some examples of popular links and memes (shared by progressives and atheists) that aren't tethered to sources or are outright lies.VIDEO of this speech.Become a supporter of this podcast: https://www.spreaker.com/podcast/thethinkingatheist--3270347/support.

Send a text to Melissa and she'll answer it on the next episode. Back-to-school can look perfectly fine on the calendar and still feel like a full-body shock to your family. The earlier mornings, new routines, bigger social pressure, and constant mental focus don't just change behavior, they load the nervous system. When that load climbs, immunity and digestion often take the hit first, which is why so many kids melt down, stop sleeping well, complain of stomach aches, or come down with something in the first few weeks.We talk through what's actually happening under the surface: stress and fight-or-flight, rising cortisol, less rest, and a temporarily weaker immune response that makes everyday exposures feel like a tidal wave. We also share what we watch for when kids can't say “I'm stressed,” like clinginess, irritability, bedwetting, nausea, fatigue, headaches, and sudden emotional sensitivity. Our goal is to help you see these symptoms as signals you can respond to with steadiness, not as problems to punish or panic about.Then we get practical with homeopathy for kids during school transitions, including remedy patterns like Gelsemium for anticipatory anxiety and weakness, Pulsatilla for sensitive separation stress, Calcarea carbonica for kids who need routine, Silica for low stamina and frequent illness, Natrum muriaticum for inward stress, Arsenicum album for anxious perfectionism with digestive upset, and Baryta carbonica for severe shyness. We also cover routines that actually help: easing into schedules early, protecting sleep, supporting digestion with nourishing meals, limiting overscheduling, and building emotional check-ins and daily “refuel” time outside or at home.If you want a calmer, more resilient back-to-school season, listen now, share it with a parent friend, and subscribe so you don't miss what's next. After you listen, will you leave a review and tell us what your child struggles with most during transitions?You may also gain Access to my Fullscript dispensary and save 30% by going to: https://us.fullscript.com/welcome/mcrenshaw FIND ME!

This episode digs into a controversial theory about SARS-CoV-2 origins, focusing on documents, timelines, and lab-to-lab collaboration rather than the usual public narrative. Jim Haslam lays out his case for how the virus was engineered as part of animal vaccine research, while George Howard helps connect the investigative and public-transparency angles. The conversation also focuses on UNC records, Rocky Mountain Lab, Wuhan, and the broader issue of dual-use biodefense research. Jim Haslam Author of COVID-19: Mystery Solved: It leaked from a Wuhan lab but it's not Chinese junk: https://a.co/d/gD8JQqi https://jimhaslam.substack.com/ https://x.com/jhas5 George Howard Pajama scientist and former business owner. More than 1K Younger Dryas Impact citations since 2007. Founding Partner Titan Network. https://carolinaflu.org/ https://x.com/CosmicTusk Key Topics Jim Haslam explains the core thesis of his book, COVID-19 Mystery Solved, arguing that SARS-CoV-2 emerged from a U.S. led research network rather than a simple Wuhan lab accident. The discussion centers on Ralph Baric, the University of North Carolina, and documents Haslam says show early work on a SARS-like genome and a furin cleavage site. George Howard frames the issue as a transparency battle, pointing listeners to the Carolinaflu.org petition and UNC's ongoing resistance to releasing records. The hosts revisit the mainstream lab leak narrative and debate when public opinion shifted from "impossible" to "probably lab leak." A major thread is the claim that the virus was developed as an animal vaccine model involving bats, mink, deer, ferrets, and hamsters. Haslam argues the research was dual-use and aerosol-focused, with Vincent Munster and Tony Fauci's biodefense ecosystem playing major roles in making the pathogen highly transmissible. The conversation returns to FOIA material, email trails, and what the guests describe as incriminating silences or resignations from researchers involved in the work. The group discusses the February 2020 call, the proximal origin paper, and how the scientific and media response shaped the public story. George Howard emphasizes that the UNC document fight is still unfinished, with thousands of pre-pandemic records allegedly still withheld. The episode closes with a call for listeners to support transparency efforts and read Haslam's book for the full argument. To gain access to the second half of show and our Plus feed for audio and podcast please clink the link http://www.grimericaoutlawed.ca/support. For second half of video (when applicable and audio) go to our Substack and Subscribe. https://grimericaoutlawed.substack.com/ or to our Locals  https://grimericaoutlawed.locals.com/ or Patreon https://www.patreon.com/grimericaoutlawed   https://www.skool.com/audiobooks THE GRIMOIRE Audiobook Club and Library https://pegsandjokers.ca/ Family and Friends Cards and Pegs Boardgame online https://www.simulationmaps.com/#products Disaster Maps, Volcano Sim, Asteroid Sim, Shipwreck Map, UFO Map etc Support the show directly: https://open.spotify.com/show/2punSyd9Cw76ZtvHxMKenI?si=ImKxfMHgQZ-oshl499O4dQ&nd=1&dlsi=4c25fa9c78674de3 Watch or Listen on Spotify https://grimerica.ca/support-2/ Our Adultbrain Audiobook Podcast and Website: www.adultbrain.ca Check out our next trip/conference/meetup - Contact at the Cabin www.contactatthecabin.com Join the chat / hangout with a bunch of fellow Grimericans Https://t.me.grimerica grimerica.ca/chats   Discord Chats Darren's books www.acanadianshame.ca Sign up for our newsletter http://www.grimerica.ca/news InstaGRAM https://www.instagram.com/the_grimerica_show_podcast/ Purchase swag, with partial proceeds donated to the show www.grimerica.ca/swag ART - Napolean Duheme's site http://www.lostbreadcomic.com/ MUSIC Tru Northperception, Felix's Site sirfelix.bandcamp.com   Timestamps 00:00 — Opening banter and guest introductions 01:02 — Jim Haslam begins the origin theory 02:01 — Ralph Baric, DARPA, and the alleged pre-confession 03:23 — Animal vaccine research and the Wuhan connection 05:43 — The Facebook fact-checker angle 07:14 — When the mainstream narrative changed 08:44 — Mink, ferrets, and serial passage 10:04 — The self-spreading animal vaccine theory 13:15 — Immune evasion and why it mattered 14:41 — Bats as the reservoir host 17:25 — Fauci's Rocky Mountain Lab 21:25 — Cell phone data and the Wuhan BSL-4 timeline 26:25 — The failed DARPA grant and second-round research 30:56 — Variants, especially D614G 35:45 — Vincent Munster and animal transmission models 40:57 — Carolinaflu.org and the UNC records fight 46:33 — Was the leak intentional or accidental? 50:12 — The Seattle traveler and the WA1 strain 51:44 — Aerosol spread, masks, and particle size 59:24 — The alleged withheld antidote 60:59 — The smoking gun email 64:28 — Baric's overlap with Moderna's mRNA research 69:12 — The theory of withholding the antidote 73:24 — "Not my lab" and the bat lady's three words 76:08 — The January 2020 phone calls and February conference call 79:33 — Fauci, guilt, and the turning point 82:43 — Dual-use research and regulatory failures 86:41 — Closing reflections and why the case matters                        

The Gut-Brain Connection: Repairing Gut Health Can Heal Chronic Conditions Many Americans suffer from gut dysregulation. Because crucial mood-regulating chemicals are generated in the gut microbiome, ignoring these warning signs can have profound effects on our overall mental and physical health. Our expert explains the strong connect between gut health, chronic disease, and emotional well-being – and how to heal your gut microbiome. Guest: Martha Carlin, founder, BiotiQuest author, Connected When Immune Cells Go Rogue: The Rapid Rise Of Eosinophilic Esophagitis Our bodies are intricate machines where every cell has a specific job. But when specialized allergy-fighting white blood cells migrate into the esophagus, severe dysfunction follows. Our expert explains how this triggers a chronic immune condition that has rapidly become one of the fastest-growing digestive diseases and can severely disrupt daily life. Guest: Dr. Evan Dellon, professor of medicine, University of North Carolina, director, Center for Esophageal Diseases & Swallowing Facebook: ingoodhealthpodX: @ ingoodhealthpodIG: @ingoodhealthpodYouTube: @ingoodhealthpodSpotify Apple Podcast In Good Health PodcastSubscribed to the newsletterFull ArchiveContact UsBecome an Affiliate Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

When Immune Cells Go Rogue: The Rapid Rise Of Eosinophilic Esophagitis Our bodies are intricate machines where every cell has a specific job. But when specialized allergy-fighting white blood cells migrate into the esophagus, severe dysfunction follows. Our expert explains how this triggers a chronic immune condition that has rapidly become one of the fastest-growing digestive diseases and can severely disrupt daily life. Guest: Dr. Evan Dellon, professor of medicine, University of North Carolina, director, Center for Esophageal Diseases & Swallowing Host: Greg Johnson Producer: Kristen Farrah Facebook: ingoodhealthpodX: @ ingoodhealthpodIG: @ingoodhealthpodYouTube: @ingoodhealthpodSpotify Apple Podcast In Good Health PodcastSubscribed to the newsletterFull ArchiveContact UsBecome an Affiliate Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Jerry Hickey discusses heart and brain supplements and Dr. Amanda discusses best ways to manage seasonal allergies.See omnystudio.com/listener for privacy information.

Adam helps a client to release childhood beliefs that they won't amount to much and also that it's wrong to go further ahead than others. Adam helps them stop thinking about being better than others and instead focus on how to be more valuable. Using various metaphors, this is a useful session for those who have a fear of judgement. FREE STUFF AND DISCOUNTS:

You finished the list. You sorted everything into thyroid or immune. And somehow that made it worse, because now you are looking at two full buckets and every single thing in them looks like it should be the thing you do today. So you did nothing. Or you picked five things, went hard, and lasted about eleven days. That is not a discipline problem. Sorting is triage, not treatment. It tells you what to work on first. But nobody ever explains the "first" part, and that gap is where most women get stuck. In this episode I walk through the three rules I use to decide what actually comes next, why the most important thing is almost never the right place to start, and what six winters of working on one single trigger taught me about doing less at a time. What you'll learn Why "address everything at once" sounds responsible and still falls apart in eleven days Why the thyroid bucket comes first (fatigue, brain fog, cold, and weight resistance show up in both buckets, and you cannot tell them apart through the static) How to pick your first immune bucket step by choosing the cheapest repeatable thing instead of the most dramatic one Why changing five things at once teaches you nothing, even when you feel better The question that replaces "which one is most important" and actually gets you moving Resources mentioned 10 Questions to Ask Your Doctor (free guide) https://health-with-hashimotos.kit.com/10-questions Episode 214, Sorting Hashimoto's labs into thyroid or immune buckets https://healthwithhashimotos.com/214-sorting-hashimotos-labs/ The Simple Habits Program. Twelve weeks of structure, not intensity. One small habit each week. This is a text message based program. Enrollment opens Sunday, September 13 and closes Saturday, September 26 at 10pm Central. The cohort runs September 27 through December 19. This is the last time it runs as a cohort. https://healthwithhashimotos.com/simple-habits-program/   NEW HERE? START HERE. New to the podcast? Start with the free guide, 10 Questions to Ask Your Doctor. https://health-with-hashimotos.kit.com/10-questions   READY TO SORT YOUR HASHIMOTO'S? Hashimoto's Decoded: Thyroid or Immune walks you through sorting everything into thyroid or immune, in under an hour, with a workbook to help you figure out your next step. https://healthwithhashimotos.com/hashimotos-decoded/   JOIN THE HEALTH WITH HASHIMOTO'S COMMUNITY Join the free Health with Hashimoto's community on Skool. It's a supportive space for women navigating Hashimoto's, and it's free to join. https://www.skool.com/health-with-hashimotos/about   Find all my other resources, including products and supplements I recommend, on my resource page: https://healthwithhashimotos.com/resources/   ABOUT THE PODCAST & ESTHER The Health with Hashimoto's podcast helps you sort your Hashimoto's into thyroid or immune, so you can finally understand what's happening in your body and what to do about it. Hosted by Esther Yunkin, a registered nurse and holistic health educator with 25 years of nursing experience.   This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure, or prevent any disease.

Matthew Lee, Jeffrey A SoRelle, Arun Everest-Dass, David E Gerber, Mitchell S von Itzstein. Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy. Clin Chem 2026; 72(9): 926–47. https://doi.org/10.1093/clinchem/hvag062

On this episode of Vitality Radio, Jared kicks off a 4 part series challenging the way we think about symptoms. Are fever, inflammation, and pain problems to eliminate, or intelligent responses designed to protect and repair the body? Jared explores why the body creates these signals, what they may be trying to accomplish, and what can happen when we automatically suppress them. He examines fever and immune response, inflammation and tissue repair, pain as protective communication, and the widespread use of acetaminophen, NSAIDs, and opioids. You'll also hear the troubling history of Vioxx and OxyContin and why understanding the cause behind a symptom matters. This episode offers a different framework - listen to what your body is telling you before simply trying to silence the signal. Additional Information:***Watch for all 4 parts of this series on Symptoms!Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.This podcast is produced by DrTalks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/

In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan welcomes pediatric integrative medicine expert Dr. Somer DelSignore to explore why childhood immune health may have profound implications for lifelong health and disease risk. As chronic illness, immune dysfunction, behavioral challenges, and neurodevelopmental conditions become increasingly complex in children, Dr. DelSignore explains why symptoms shouldn't always be viewed in isolation. Instead, she investigates the interconnected roles of inflammation, infections, gut health, environmental toxins, nutrition, genetics, and immune regulation. Together, they explore her R.E.S.E.T. Protocol, the potential biomedical drivers behind conditions such as ADHD and PANS/PANDAS, the importance of investigating mold and vector-borne infections, and practical ways parents can help build greater immune resilience in their children.

BUFFALO, NY – September 9, 2026 – A new #review was #published in Volume 17 of Oncotarget on September 8, 2026, titled “Re-expression of MHC-I to treat CNS cancers.” The review examines emerging strategies to restore major histocompatibility complex class I (MHC-I) expression in cancers of the central nervous system (CNS), with the goal of making these tumors more visible and vulnerable to immune attack. The review was authored by Arseniy E. Yuzhalin from the Sirius University of Science and Technology in Sochi, Russia. Malignant central nervous system (CNS) tumors such as glioblastoma and brain metastases are often immunologically “cold,” with limited T-cell infiltration and poor responses to immune checkpoint therapy. One important mechanism of immune escape is the reduction or loss of major histocompatibility complex class I (MHC-I), which normally displays tumor-associated antigens to cytotoxic CD8+ T cells. When MHC-I expression falls, cancer cells become less visible to immune surveillance. The review examines several strategies for restoring MHC-I expression. Epigenetic therapies, including histone deacetylase and DNA methyltransferase inhibitors, could potentially reverse epigenetic silencing of MHC-I genes, although blood-brain barrier penetration remains a major limitation in CNS cancers. A more direct approach could use adeno-associated virus (AAV) vectors to deliver patient-specific HLA-A, HLA-B, or HLA-C genes or transcription factors such as NLRC5 that promote MHC-I expression. However, efficient tumor targeting, gene delivery, and control of the immunosuppressive tumor microenvironment remain unresolved challenges. The review also highlights PCSK9 inhibition as a clinically relevant strategy. PCSK9 can promote MHC-I degradation, and a recent surgical-window trial tested the cholesterol-lowering drug evolocumab in patients with newly diagnosed or recurrent glioma. A single preoperative dose showed measurable blood-brain barrier penetration, and tumors with higher drug concentrations displayed increased surface MHC-I expression, greater CD8+ T-cell infiltration, and enhanced cytotoxic activity. These findings provide proof-of-mechanism, although drug delivery into the brain remains a limiting factor. Full press release - https://www.oncotarget.com/news/pr/restoring-mhc-i-expression-could-strengthen-immune-responses-against-cns-cancers/ DOI - https://doi.org/10.18632/oncotarget.28917 Correspondence to - Arseniy E. Yuzhalin - yuzhalin.ae@talantiuspeh.ru Abstract video - https://www.youtube.com/watch?v=NDvQ7QS3DFg Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28917 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, brain tumor, CNS cancer, glioblastoma, brain metastasis; MHC-I To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Paul Romness, CEO, President, and Chair of OS Therapies, which is developing an immunotherapy to treat osteosarcoma, a rare bone cancer that stimulates the immune system to identify and eliminate cancer cells. The approach upregulates positive immune factors amd downregulates negative factors resulting in a dual biomarker response and better management of side effects. OS Therapies plans to expand its platform technology to other solid tumors with significant unmet needs, including breast,  esophageal, and colorectal cancer.    Paul explains, "What I think is important is that OS Therapies was started for unmet need, not just in the United States, but there are 20,000 patients a year that get osteosarcoma globally. And it's our responsibility to address patients globally. And it is interesting from a regulatory standpoint, as they start to coordinate with each other, that there are routes for us to get approval in the United States through MHRA, through the UK, and through the collaboration with the EU, with a system called Orbis. But we're also still very confident and very encouraged by the progress we've made with the FDA over the last few months."   "And for OS Therapies, we will pivot to other solid tumors. So our primary mission is osteosarcoma, but once we get approval, we'll pivot to other solid tumors that still have a lot of unmet medical need, like breast cancer. There are still 40,000, mostly women, dying each year of breast cancer, esophageal cancer, or colorectal cancer. So if we can encourage other companies to come into this space, we'll not only achieve our primary mission, but we'll also deliver for patients, which is our goal." #OSTherapies #Osteosarcoma #RareDisease #RareCancer #PediatricOncology #RareDiseaseOncology #SolidTumors #Immunotherapy #ListeriaCancerImmunotherapy #Biomarkers #Oncology #ClinicalTrials #HER2 #CancerResearch #ComparativeOncology#CanineOsteosarcoma ostherapies.com Download the transcript here

Paul Romness, CEO, President, and Chair of OS Therapies, which is developing an immunotherapy to treat osteosarcoma, a rare bone cancer that stimulates the immune system to identify and eliminate cancer cells. The approach upregulates positive immune factors amd downregulates negative factors resulting in a dual biomarker response and better management of side effects. OS Therapies plans to expand its platform technology to other solid tumors with significant unmet needs, including breast,  esophageal, and colorectal cancer.    Paul explains, "What I think is important is that OS Therapies was started for unmet need, not just in the United States, but there are 20,000 patients a year that get osteosarcoma globally. And it's our responsibility to address patients globally. And it is interesting from a regulatory standpoint, as they start to coordinate with each other, that there are routes for us to get approval in the United States through MHRA, through the UK, and through the collaboration with the EU, with a system called Orbis. But we're also still very confident and very encouraged by the progress we've made with the FDA over the last few months."   "And for OS Therapies, we will pivot to other solid tumors. So our primary mission is osteosarcoma, but once we get approval, we'll pivot to other solid tumors that still have a lot of unmet medical need, like breast cancer. There are still 40,000, mostly women, dying each year of breast cancer, esophageal cancer, or colorectal cancer. So if we can encourage other companies to come into this space, we'll not only achieve our primary mission, but we'll also deliver for patients, which is our goal." #OSTherapies #Osteosarcoma #RareDisease #RareCancer #PediatricOncology #RareDiseaseOncology #SolidTumors #Immunotherapy #ListeriaCancerImmunotherapy #Biomarkers #Oncology #ClinicalTrials #HER2 #CancerResearch #ComparativeOncology#CanineOsteosarcoma ostherapies.com Listen to the podcast here

Adam Waickman discusses the unusual reason he got into studying immunology just in humans, his important studies on Dengue virus vaccine antibodies, and the problematic phenomenon of antibody dependent enhancement. Host: Cindy Leifer Guest: Adam Waickman Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Waickman Lab Website Dengue virus human infection model (Sci Trans Med, 2022) mRNA vectored antibody against Dengue (Antiviral Res, 2025) B cell receptor enhancement of Dengue (PLoS Path, 2024) Dengue infection macrophage transcriptional profiles (J Virol, 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Cytopenias and infections are familiar complications of branched-chain organic acidemias, but are they simply consequences of metabolic decompensation? Abdul Shakerdi and Jerry Vockley join the JIMD Podcast to explore evidence that persistent immune dysfunction and inflammation may be fundamental parts of the disease phenotype, with implications for clinical care, research and emerging therapies. Immune Dysregulation in Branched Chain Organic Acidemias Abdul L. Shakerdi, et al https://doi.org/10.1002/jimd.70203

How serious is Hashimoto's disease? Nobody answered that at your appointment. You got a prescription and a follow-up in six weeks. Or you got told your numbers are fine for now and we are just going to keep an eye on things. Either way, you walked out not knowing whether to brush this off or worry about it every day. The answer sits in between those two. Hashimoto's is two things and not one. It is a thyroid that cannot keep up, and it is an immune system attacking that thyroid. Medication can help handle the first one. The second one is all yours to work on. In episode 216, Esther gives you the facts without the fear, including what she reads in her own thyroid books about what happens when hypothyroidism goes unwatched, and why she gets most serious about this with women who are pregnant or trying to be. In this episode, you'll learn: Why the immune attack is not the life-threatening part, and what actually is How long your antibodies can be elevated before symptoms or your TSH ever reflect it The five labs to look at so you know which side is asking for your attention right now Hit play and get the answer you did not get at your appointment. Resources mentioned: Esther's first episode, where she shares her own diagnosis story: https://healthwithhashimotos.com/my-journey/   NEW HERE? START HERE. New to the podcast? Start with the free guide, 10 Questions to Ask Your Doctor. https://health-with-hashimotos.kit.com/10-questions READY TO SORT YOUR HASHIMOTO'S? Hashimoto's Decoded: Thyroid or Immune walks you through sorting everything into thyroid or immune, in under an hour, with a workbook to help you figure out your next step. https://healthwithhashimotos.com/hashimotos-decoded/ JOIN THE HEALTH WITH HASHIMOTO'S COMMUNITY Join the free Health with Hashimoto's community on Skool. It's a supportive space for women navigating Hashimoto's, and it's free to join. https://www.skool.com/health-with-hashimotos/about Find all my other resources, including products and supplements I recommend, on my resource page: https://healthwithhashimotos.com/resources/ ABOUT THE PODCAST & ESTHER The Health with Hashimoto's podcast helps you sort your Hashimoto's into thyroid or immune, so you can finally understand what's happening in your body and what to do about it. Hosted by Esther Yunkin, a registered nurse and holistic health educator with 25 years of nursing experience. This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure, or prevent any disease.

VLOG Sept 3 Maduro moves to dismiss as immune https://www.patreon.com/MatthewRussellLee/posts/long-arm-of-law-168215766 Short Eyes Doc Zhao (with Agnifilo firm) ordered free https://matthewrussellleeicp.substack.com/p/short-eyes-doc-nyc-doctor-charges Fed FOIA on Enova, in-person? https://www.courtlistener.com/docket/73418408/15/lee-v-board-of-governors-of-the-federal-reserve-system/ @UKUN_NewYork ignores FOIA 2000: https://innercitypress.com/UNSGfoia1aukicp090226.html

In this JIMD Reports Shortcast, Dr Eamon McCarron presents a challenging pregnancy in a woman with lysinuric protein intolerance complicated by immune dysregulation and severe thrombocytopenia. Hear how multidisciplinary management supported a favourable outcome for both mother and baby. Pregnancy in Lysinuric Protein Intolerance Complicated by Immune Dysregulation and Severe Thrombocytopenia Eamon P. McCarron, et al https://doi.org/10.1002/jmd2.70109

UCLA researchers found that creatine may do more than support muscle performance; early research suggests it also helps power key immune cells that coordinate the body's defense against cancer When immune cells were unable to absorb creatine, they showed lower survival, weaker activation, and a reduced ability to stimulate the T cells responsible for attacking abnormal cells Creatine helped immune cells maintain higher levels of ATP, the body's primary cellular energy source, allowing them to stay active and communicate more effectively In a mouse melanoma model, creatine supplementation was linked to slower tumor growth, more active immune cells inside tumors, and stronger cancer-fighting immune responses Supporting healthy cellular energy through adequate creatine intake, nutrient-dense foods, healthy carbohydrates, and lifestyle habits that strengthen mitochondrial function may help create a stronger foundation for immune health

In this episode Andrea Samadi explores how movement and sleep work together in a "brain operating system" for human performance, focusing on restorative sleep (deep + REM), personal WHOOP data, and the trade-offs created by early-morning exercise. She shares four lessons and a simple experiment to help listeners protect REM and deep sleep while maintaining an active life, emphasizing weekly rhythms, small changes, and tracking patterns rather than chasing perfect numbers. SEASON 16 | BONUS EPISODE 4 RESTORATIVE SLEEP Where Adaptation Happens Why deep sleep restores the body, REM helps integrate experience, and healthy habits must work together. ON BONUS EPISODE 4, YOU'LL LEARN: ✔ What restorative sleep really measures ✔ How deep sleep and REM support different forms of recovery ✔ Why REM percentage and duration tell different stories ✔ What my six-month sleep data revealed ✔ The hidden tradeoff behind my 4:00 AM hiking routine ✔ What happened when I slept just 21 minutes longer ✔ Why healthy habits can sometimes compete ✔ How to protect sleep without giving up movement ✔ 4 Lessons and a simple experiment for discovering your own best rhythm Episode Introduction Welcome back to the Neuroscience Meets Social and Emotional Learning Podcast, where we bridge neuroscience, social and emotional learning, and human performance to create measurable improvements in well-being, achievement, leadership, productivity and results. I'm Andrea Samadi, and throughout Season 16 we have been building what I call the Brain's Operating System for Human Performance—a neuroscience-based framework for understanding how the systems of the brain and body work together to influence how we learn, adapt, connect, lead and ultimately perform. We are currently in Phase 3: Movement, Learning and Cognition. Movement is the foundation of this phase because it affects far more than our muscles. When we move, we activate processes throughout the brain and body. Movement supports neurogenesis—the development of new neurons—particularly in areas involved in learning and memory. It strengthens connections between neurons through synaptic plasticity. We covered neurogenesis on EP 141[i] if you want to revisit that episode, if you are as curious as I am about how to regrow our brain cells. Movement that we are learning in this phase, also influences brain chemicals such as dopamine, serotonin, norepinephrine and acetylcholine, which affect motivation, mood, attention and learning. Movement can also strengthen our resilience by helping us manage stress and become more emotionally flexible. It builds sleep pressure, (the longer we stay awake, the more adenosine accumulates that increases our need or “pressure” to rest) which can support deeper, more restorative sleep. And over time, these changes may contribute to greater creativity, insight, endurance and human potential. But movement only creates the stimulus. The benefits don't come from movement alone. They come from the way the brain and body respond to that movement—and that response is called adaptation. Movement changes the brain. Adaptation changes the body. Recovery is what connects the effort we make today with the strength, resilience and capacity we hope to build tomorrow. Without adequate recovery, we can receive the stimulus without fully receiving the benefit. That is why sleep belongs inside the Movement Loop. Sleep is not separate from movement, learning or performance. It is one of the primary places where the brain and body respond to what we have asked them to do. Throughout Season 16, I've been sharing some of my own health and performance data as a living case study—not because everyone should try to reproduce my numbers, but because our individual trends can help us understand how neuroscience shows up in everyday life. I thought that if I was curious about understanding my numbers—and using them to improve my health, well-being and productivity—then other people might benefit from what I've learned along the way. My data has helped me see that movement, recovery and performance cannot be understood in isolation. They work together as a system: Movement creates the stimulus. Recovery creates the conditions for adaptation. Restorative sleep is one of the places where that adaptation unfolds. And this brings us to one of the most important recovery metrics I've learned to follow: Restorative sleep. We often celebrate what happens while we're awake: Our productivity. Our focus. Our learning. Our movement. Our performance. But much of the adaptation supporting those abilities happens while we sleep. Deep sleep supports physical restoration. REM sleep supports emotional processing, memory integration and cognitive flexibility. Together, these stages help convert the demands of one day into greater capacity for the next. This episode began with one honest question about my own routine: THE QUESTION: What am I gaining by waking at 4:00 AM to hike—and what might I be giving up by not sleeping longer? This is not simply an episode about sleeping more. It is about creating a rhythm in which two essential health behaviors—sleep and exercise—support one another instead of competing for the same limited hours. You will see my data exactly as it is. Sleep is one of the weaker links in my current health routine, which makes it a useful place to learn. The goal is not to judge the data. The goal is to let the data ask a better question. Lesson 1: Restorative Sleep Contains Two Stories WHOOP (the wearable device that I use to measure sleep) defines restorative sleep as the combined time spent in deep sleep, also called slow-wave sleep, and REM sleep. Combining the two creates a useful overview, but separating them reveals two different parts of the story. Deep Sleep or Slow-Wave Sleep: Physical Restoration Deep sleep is concentrated more heavily in the earlier part of the night and supports processes associated with physical restoration. It is relevant after hiking, Zone 2 exercise, strength training and other demanding activity because sleep is part of how the body responds to the strain we create. During deep sleep: Tissue repair is supported. Growth hormone release increases. Immune function is supported. Energy is restored. The body adapts to physical strain. REM Sleep: Integration REM stands for rapid eye movement sleep and is known as the “mentally restorative” stage of sleep. This is where most dreams occur, and short-term memories are converted into long-term memories. During REM, the brain is highly active while most voluntary muscles remain temporarily inhibited. I'll never forget the part of our interview with Dr. Jaland Balal[ii], when he explained that this feature is what keeps us safe from moving around too much while we are sleeping, keeping our sleeping partners safe. REM has been associated with: Emotional processing Memory integration Aspects of learning Cognitive flexibility Creative associations Connecting new information with previous experiences Memory is supported across several sleep stages—not by REM alone. REM helps the brain process, connect and integrate. REM periods also tend to become longer as the night progresses. That means shortening the end of the sleep window may disproportionately reduce the opportunity for the longer, more REM-rich cycles that occur toward morning. Deep sleep helps restore the body. REM helps integrate the brain. We need both. That second sentence is personally meaningful because I have logged my dreams for years. A dream is not a diagnosis or a literal solution, and dreams can occur outside REM. But a dream log gives me a qualitative record of recurring emotions, images, relationships, problems and emerging ideas that my mind may still be processing. Since I enjoy learning, interviewing, writing, teaching and connecting ideas across neuroscience and social-emotional learning, REM matters for more than dream recall (which by itself is fascinating and something we will look deeper at in Phase 5 with Integration and Meaning). Lesson 2: My Data Revealed a Duration Gap When I looked at my WHOOP trends, the total restorative-sleep number was only the beginning.   Metric My average   Six-month restorative sleep 2 hr 43 min   Lifetime REM 1 hr 37 min   Last 90 days REM 1 hr 18 min   Last 30 days REM 1 hr 20 min   Recent REM percentage About 20% When I looked at six months of WHOOP data, my average restorative sleep was: 2 hours and 43 minutes per night. That number gave me the total time spent in deep sleep and REM—but it did not tell me how those two stages were distributed. When I separated them, another story emerged. My lifetime REM average was approximately: 1 hour and 37 minutes per night. But over my more recent periods, that changed: Last 90 days: approximately 1 hour and 18 minutes Last 30 days: approximately 1 hour and 20 minutes Recent REM percentage: approximately 20% of my total sleep Twenty percent is within a commonly reported adult range. But compared with my own lifetime average, my recent REM duration was approximately 17–19 minutes lower per night. That distinction matters. My REM percentage may appear healthy while my total REM duration is still lower than my personal historical average. So my real question became: Not “Is my REM normal?” but “What conditions help my brain produce more of its own normal REM?” This is the value of tracking. THE DATA LESSON: A population range provides context. Your baseline provides the story. Your trend gives you a question to test.           Lesson 3: The 4:00 AM Tradeoff I love hiking early. It gives me cardiovascular conditioning, time outside, morning light, mental clarity and consistency. In Arizona, it also helps me finish before extreme heat heats around 8am. But if I go to bed at 8:30 PM and wake at 4:00 AM, I create a maximum sleep opportunity of seven and a half hours. That is time in bed—not necessarily time asleep. It does not include the time required to fall asleep or periods of wakefulness during the night. If I remain in bed until 6:00 AM, I create two additional hours of sleep opportunity. Those two hours would not equal two hours of REM. They would contain a mixture of sleep stages and perhaps brief wakefulness. But because REM episodes generally lengthen later in the night, the added opportunity may protect some of the more REM-rich portion of sleep. If you want to understand sleep cycles, I highly recommend taking Dr. Mathew Walker's Masterclass[iii] The Science of Better Sleep. What the Early 4am Wake Gives Me Early movement and consistency Cardiovascular conditioning Time outdoors and morning light The mental and emotional benefits of hiking What Might it Cost Me Up to two hours of total sleep opportunity (lost) Part of one or more later sleep cycles (lost) Greater opportunity for REM and dream recall (important to me) Time for memory and emotional processing across sleep (important to me) The accurate interpretation is not that I lose two hours of REM. It is that I may give up two hours of sleep opportunity containing some of the night's more REM-rich cycles. That led to my central realization: healthy behaviors (like my early wake to hike) can compete when their timing is not coordinated. MY AHA MOMENT: Am I creating better sleep through movement—or repeatedly borrowing from the final part of sleep to make that movement happen? My wearable cannot prove that early wake times caused the change. Consumer wearables estimate sleep stages; they do not measure them with clinical polysomnography. But the pattern gives me a reasonable hypothesis to test. That is what self-tracking should do: not make us anxious about a number, but help us ask a better question. A Real-Time Clue: What 21 More Minutes Revealed While preparing this episode, my data gave me a real-time example of the tradeoff. On Thursday, August 27, I woke at 4:21 AM instead of 4:00 AM. That night I recorded three hours and two minutes of restorative sleep—the highest total of the week. It included one hour and seven minutes of deep sleep and one hour and 55 minutes of REM. That REM duration was approximately 35 minutes above my recent 30-day average. My graph in the show notes showed a substantial REM period close to the end of the sleep window. Twenty-one additional minutes cannot explain a 35-minute difference, and one night cannot establish cause. Sleep varies from night to night. But the observation supports the hypothesis that a 4:00 AM alarm may sometimes interrupt a REM period already underway. I also remembered my dream and added it to my dream log. That gave me another kind of data: not just how long I slept, but what my mind may have been processing, integrating or connecting. One night is a clue—not proof. Watch the trend. The lesson is not that 4:21 AM is a magical wake time. The lesson is that the final portion of sleep may be more valuable than its length makes it appear. A small extension may sometimes allow the brain to finish a cycle that an earlier alarm (or your natural body's alarm) would interrupt. Lesson 4: Build a Rhythm, Not a Perfect Day The remedy I've concluded is not to stop hiking, (I would be miserable) and it is not to maximize sleep or exercise in isolation (I wouldn't feel productive sleeping in longer). The solution is to create a weekly rhythm in which movement provides the stimulus and sleep protects the opportunity for adaptation. For me, that rhythm can include two kinds of days: 1. Early-Hike Days (twice a week) When a 4:00 AM wake time is necessary, (and possible). I can treat bedtime as part of the training plan. If family responsibilities the night before make a very early bedtime unrealistic, I can recognize that constraint and adapt. But it is important that I get to bed by 8:30pm if I want to wake up 4am.   2. Sleep-Protected Mornings On selected non-hiking days, I can remain asleep until approximately 5:00 or 6:00 AM and move later.  These mornings create more opportunity for later sleep cycles and give me a comparison condition for my experiment. What happens if I stay in bed longer? The goal is not a perfect day. The goal is a sustainable week. The Movement Loop is not: Move → Move More → Keep Pushing. It is: Movement → Recovery → Adaptation → Performance → Greater Capacity. For you, the listener, are you giving yourself enough time to recover? To Adapt? To Increase Performance? That leads to greater capacity? Or, did you notice, like me, that there was a trade off with your schedule? Tips to Implement: Run Your Own Restorative-Sleep Experiment You do not need my wake time, my REM number or a WHOOP device to learn from your own pattern. Use this five-step experiment for two to four weeks. Establish your baseline. Record your usual bedtime, wake time, estimated sleep duration, morning energy and—if available—deep and REM sleep for at least seven nights. The Whoop device rewards users who go to bed, and wake at the same time, calling it sleep consistency. Choose one change. Add 20–60 minutes of sleep opportunity on selected mornings, or move bedtime earlier before early-training days. Avoid changing every variable at once. Stanford Professor, Dr. Andrew Huberman[iv] suggests that if you can find a way to add heat to your sleeping environment in the final 2 hours of your sleep, it can increase your REM sleep. Sleeping just 21 more minutes for me made a notable difference. Protect movement differently. On sleep-protected mornings, move later, shorten the session or choose a lower-intensity option instead of skipping movement entirely. This was the game changer for me.  I opted for a walk on sleep protected days. Track a small set of outcomes. Use total sleep, restorative sleep or dream recall if available, morning clarity, afternoon energy and exercise quality. Optional wearable metrics include recovery, HRV and resting heart rate. This is where you have to notice what you see from this ONE change. It might be obvious like mine—I noticed that extra time led to a dream that I could recall. Review the pattern—not the best night. Compare at least one or two weeks of early mornings with sleep-protected mornings. Look for a repeatable combination that supports both recovery and movement. The patterns will reveal whether the ONE thing you changed made a difference for you. If you do use a wearable, remember that sleep stages are estimates. Use the device to compare patterns under similar conditions, not to diagnose a sleep disorder or chase a perfect stage score. KEY QUESTION: Can I preserve the benefits of movement without repeatedly borrowing the time my brain and body need for recovery? A Bigger Experiment Is Still Underway I have also removed one significant sleep disruptor and am tracking what happens to my REM, sleep stress, HRV, resting heart rate and recovery. I do not want to draw conclusions too early. I want enough data to distinguish a temporary response from a genuine physiological shift, so I will return to that experiment in a future episode. For now, the question is narrower: how can I protect restorative sleep while continuing to live an active life? Review  To review and conclude this week's BONUS EP 4, let's bring the four lessons—and the data—together. Lesson 1: Restorative Sleep Contains Two Stories Restorative sleep combines two important stages: Deep sleep and REM sleep. Deep sleep supports physical restoration and adaptation. REM supports emotional processing, memory integration, cognitive flexibility and creative association. We need both. Every morning, I look at my restorative-sleep total and hope it is closer to three hours than two. But this episode taught me not to stop at that combined number. The total gives me the overview. Deep sleep and REM tell me how that restoration was distributed. And REM is personally meaningful to me for another reason: I have recorded my dreams for years. Dream recall does not provide a literal interpretation of everything happening in my life. But it gives me a qualitative record of the emotions, experiences, problems and ideas my mind may still be processing. So Lesson 1 is: Restorative sleep is not one number. It contains the story of how the body restores—and how the brain integrates. Lesson 2: My Data Revealed a Duration Gap Over the past six months, my average restorative sleep has been two hours and 43 minutes. My recent REM has represented approximately 20% of my total sleep—a percentage that may appear reasonable. But when I looked at duration rather than percentage, I discovered that my recent REM was approximately 17–19 minutes below my lifetime average. REM percentage and REM duration answer different questions. Percentage tells me how my sleep was distributed. Duration tells me how much actual time my brain spent in that stage. That distinction matters because someone can have a reasonable REM percentage but still receive less total REM when the overall sleep window is shortened. So Lesson 2 is: A percentage can look healthy while duration still reveals a gap. This is why personal baselines are so valuable. Our trends help us identify the question we need to investigate. Lesson 3: The 4:00 AM Wake Time Creates a Tradeoff My data led me to examine my 4:00 AM wake time. Waking at 4:00 does not mean I am losing two hours of REM. It means I may be giving up two hours of total sleep opportunity—time that could contain approximately one to one-and-a-half later, more REM-rich sleep cycles. Then, while I was preparing this episode, I received an early clue. When I slept just 21 minutes longer—waking at 4:21 instead of 4:00—my restorative sleep reached three hours and two minutes. That included one hour and seven minutes of deep sleep and one hour and 55 minutes of REM—approximately 35 minutes more REM than my recent 30-day average. I also remembered my dream and added it to my dream log. Twenty-one additional minutes cannot explain the entire 35-minute difference, and one night does not prove causation. But the graph showed a substantial REM period close to the end of my sleep window. That gave me a clue worth investigating: My 4:00 AM wake time may sometimes interrupt a REM period that is already underway. So Lesson 3 is: The final portion of sleep may be more valuable than its length makes it appear. This does not mean that 4:21 is a magical wake time. It means that a small extension may sometimes allow the brain to finish a cycle that an earlier wake time would interrupt. Dr. Huberman, and Dr. Holmes offered tips to stay in bed longer, to capture REM rich sleep time. Lesson 4: Build a Rhythm, Not a Perfect Day My early-morning hikes provide cardiovascular conditioning, time outside, morning light, mental clarity and emotional regulation. They support my health. They also make me happy. The remedy is not to stop exercising and become miserable. The remedy is to protect sleep as well as I realistically can and arrange movement around a more complete sleep window. That might mean saving selected mornings for longer sleep. It might mean moving later on non-hiking days. It might mean moving bedtime earlier when possible. And it might mean shortening a workout when sleep has been limited. The goal is not to maximize sleep or exercise in isolation. It is to create a sustainable weekly rhythm in which both can happen. So Lesson 4 is: The best routine is not the one that produces a perfect number. It is the one that allows the whole system to work. Now let me ask you: Do you know how much restorative sleep you receive? Do you look beyond the total and examine both deep sleep and REM? Are you tracking percentages—or actual duration? Does your schedule give you enough sleep opportunity? And could one healthy behavior in your life be unintentionally competing with another? My restorative-sleep average gave me the overview. My REM duration revealed the tension. My 4:00 AM wake time created the hypothesis. My additional 21 minutes gave me an early clue. My next step is to test a better rhythm. That is what measurement is supposed to do. Not judge us. Not pressure us to produce a perfect number. Guide us toward a better decision. I hope this deeper look at restorative sleep encourages you to identify one small experiment of your own—not to chase a perfect number, but to discover the rhythm that helps you learn, adapt and perform at your best.   We'll see you next time as we return to Dr. John Medina's work—not to repeat what we have already learned about attention, but to answer the next question in the Movement Loop: once movement activates the brain, how does attention determine what becomes learning? From there, we'll revisit Jason Wittrock's work through a new lens: how metabolic health, nutrition and energy availability help the brain and body sustain movement, recovery and performance. Resources and Episode Pathway Phase 1: Regulation & Safety The Foundation Core Question: Is the nervous system safe enough to learn? Everything begins with regulation. Before we can focus, learn, lead, or perform, the brain first asks one fundamental question: Am I safe? Throughout Phase 1, our guests showed us that regulation isn't simply about reducing stress—it's about creating the biological conditions that allow the brain to learn, adapt, and thrive. Together we explored: Baland Jalal – how sleep, curiosity, imagination, and creativity prepare the brain for learning. https://andreasamadi.podbean.com/e/hypnagogic-genius-capture-your-best-ideas-at-the-edge-of-sleep/   Dr. Bruce Perry – why regulation, rhythm, and relationships form the foundation of every healthy nervous system.  https://andreasamadi.podbean.com/e/safety-first-why-a-regulated-brain-is-the-key-to-learning/   Dr. Sui Wong – how lifestyle medicine and autonomic balance build lifelong brain resilience. https://andreasamadi.podbean.com/e/your-eyes-the-brain-s-early-warning-system/   Rohan Dixit – how heart rate variability gives us real-time feedback on our ability to regulate stress. https://andreasamadi.podbean.com/e/breathe-to-reset-how-hrv-tech-reveals-hidden-stress/   Dr. Kristen Holmes – how recovery metrics reveal our physiological readiness to perform. https://andreasamadi.podbean.com/e/kristen-holmes-from-whoopcom-on-unlocking-a-better-you-measuring-sleep-recovery-and-strain/   Dr. Antonio Zadra – how sleep and dreaming consolidate memories, regulate emotions, and generate insight. https://andreasamadi.podbean.com/e/when-brains-dream-how-sleep-integrates-emotion-insight-and-creativity/ Together these conversations taught us that sleep and stress regulation aren't optional—they're the operating system that allows every higher brain function to work. Phase 2: Motivation & Neurochemistry The Direction Core Question: What moves us into action? Once the brain feels safe, it becomes ready to pursue goals. In Phase 2, we explored the internal chemistry that transforms intention into action. Our experts helped us understand that sustainable motivation isn't about willpower—it's about aligning our beliefs, thoughts, attention, energy, and movement. Together we discovered: Bob Proctor — our beliefs determine the direction of our lives. https://andreasamadi.podbean.com/e/belief-first-the-neuroscience-of-motivation/   Dr. Carolyn Leaf — our thinking literally changes our brain chemistry. https://andreasamadi.podbean.com/e/thoughts-as-biology-how-your-mind-shapes-neurochemistry/   Dr. John Medina — attention determines what the brain encodes and remembers. https://andreasamadi.podbean.com/e/theory-of-mind-the-missing-link-between-attention-reward-and-motivation   Dr. Anna Lembke- Dopamine, Motivation and Why the Brain Repeats Behavior https://andreasamadi.podbean.com/e/dopamine-nation-the-pleasure%e2%80%93pain-balance-that-drives-motivation/   Dr. Friederike Fabritius — managing our energy allows high performance to become sustainable. https://andreasamadi.podbean.com/e/fun-fear-focus-closing-the-motivation-loop/   Dr. Chuck Hillman & Paul Zientarski — movement activates the brain, preparing it to learn. https://andreasamadi.podbean.com/e/move-to-learn-how-movement-activates-the-brain-and-fuels-motivation/   By the end of Phase 2, we introduced what became The Motivation Loop, showing how beliefs influence thoughts, thoughts influence actions, actions create results, and results reinforce future beliefs. Phase 3: Movement, Learning & Human Performance The Transformation Core Question: How does movement change the brain—and how does recovery transform that change into performance? Now we're taking the next step. Phase 3 builds on everything we've learned so far. If Phase 1 created a regulated nervous system... If Phase 2 created motivation and direction... Phase 3 explains how the brain and body actually become stronger. Together we've explored this process through conversations with: Dr. Chuck Hillman & Paul Zientarski — why movement activates the brain before learning. https://andreasamadi.podbean.com/e/movement-first-how-a-20%e2%80%91minute-walk-lights-up-the-brain/   Dr. John Ratey — how exercise builds a healthier, younger brain. https://andreasamadi.podbean.com/e/movement-matters-how-every-move-rewires-the-brain/   Dr. Kristen Holmes — why recovery determines adaptation and readiness. https://andreasamadi.podbean.com/e/movement-isnt-enough-how-recovery-drives-real-adaptation   Dr. John Medina — how attention transforms movement into lasting learning. Jason Whitrock — how metabolism and cellular energy fuel long-term performance. WHERE WE ARE GOING NEXT Phase 4 — Connection, Emotion & Social Intelligence The Human System Core Question: How do we thrive with other people? The brain didn't evolve in isolation—it evolved through relationships. In Phase 4, we'll explore emotional intelligence, empathy, communication, trust, leadership, and psychological safety to understand how our relationships shape learning, well-being, and performance. Phase 5 — Integration & Human Performance The Complete System Core Question: How do all the systems work together? In our final phase, we'll bring everything together—regulation, motivation, movement, emotion, relationships, learning, and recovery—into one integrated framework. We'll discover how these systems work together to create measurable improvements in our well-being, achievement, leadership, productivity, and results. Selected Sleep References “What Is Restorative Sleep?” https://www.whoop.com/us/en/thelocker/what-is-restorative-sleep/ Patel AK, Reddy V, Shumway KR, Araujo JF. “Physiology, Sleep Stages.” StatPearls/NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK526132/ Goldstein AN, Walker MP. “The Role of Sleep in Emotional Brain Function.” Annual Review of Clinical Psychology. https://pmc.ncbi.nlm.nih.gov/articles/PMC4286245/ Paller KA, Creery JD, Schechtman E. “Memory and Sleep: How Sleep Cognition Can Change the Waking Mind for the Better.” Annual Review of Psychology. https://pmc.ncbi.nlm.nih.gov/articles/PMC7983127/   REFERENCES:   [i]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 141 https://andreasamadi.podbean.com/e/brain-fact-friday-on-neurogenesis-what-hurts-or-helps-your-brain-cells/   [ii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 384 Review of our Interview with Dr. Baland Jalal  https://andreasamadi.podbean.com/e/hypnagogic-genius-capture-your-best-ideas-at-the-edge-of-sleep/   [iii] www.masterclass.com Mathew Walker The Science of a Better Sleep   [iv] https://www.instagram.com/p/DbO7dKLO-c8/?hl=en Dr. Andrew Huberman on ways to increase REM sleep.  

This podcast is meant to complement my recent Ground Truths post Why Our Memory Slips After Age 50 which has all the relevant links to the 2 papers, key graphics, and other related publications. If you haven't had a chance to read that, it would be helpful to spend a few minutes to do so before listening to this podcast.Links to the 2 papers for those who don't want to look backZemke et al in Science https://www.science.org/doi/10.1126/science.adt8307Belk et al in Nature https://www.nature.com/articles/s41586-026-10939-0It's a major and fascinating discovery. We're talking about a “hostile takeover” of blood monocyte cells that invade the brain and ultimately completely replace the brain microglia. The problem is these new microglia are pro-inflammatory.A surprising finding is about CHIP (blood stem cells with mutations known as clonal hematopoiesis of indeterminate potential) that was shown to be protective. It's surprising because CHIP is common with age and until now it has been linked to bad things such as cardiovascular disease, clotting, and cancer. If this pans out, it introduces the concept of immunotherapy of the blood (“brain immunotherapy”).We discussed recent studies of microglia replacement and ways to keep our brain microglia intact, such as prevention any breakdown of the blood brain barrier.The role of latent viruses and the mechanism of benefit of the Shingles vaccine were touched on.Our conversation provides far more color and perspective about why their independent, complementary, and convergent findings are so important, debunking our longstanding belief that the microglia, the immune cells in the brain, are exclusively derived from the brain. Technology driven discovery. And what are the next steps in this line of research.I hope you found this podcast illuminating and fun. If you did, plus share it with your network. Thanks for supporting Ground Truths and your help in spreading the word.And thank to jojofinance, Elisabetta Pilotti, Daniel Rench, Dr. Sara Wolfson, Bob Fleischman, and hundreds of others for tuning into the live video with Julia Belk and Nathan Zemke! Join me for my next live video in the app. Get full access to Ground Truths at erictopol.substack.com/subscribe

You did the sorting. Thyroid on one side, immune on the other. So why does it feel like nothing has actually changed? Here is the trap. Sorting feels like progress, and it is, but so far it is all in your head. The buckets are full and nothing in either one has moved. Sorting feels safe. Starting feels like a risk. In this final episode of the summer sorting series, Esther walks you through what to do after sorting Hashimoto's into thyroid and immune. Not twelve things to do tomorrow. One thing, chosen on purpose, small enough that you will still be doing it next month. Hit play and pick your one next thing.   RESOURCES MENTIONED Hashimoto's Decoded: Thyroid or Immune, inside the classroom in the Skool community https://healthwithhashimotos.com/hashimotos-decoded/   Jumpstart to Refreshing Sleep and Rest, also in the Skool classroom    Single coaching sessions. You do not have to book the full six sessions of Hashimoto's Discernment Coaching. If you have sorted your two buckets and just need help with one thing, a single session is built for that.    NEW HERE? START HERE. New to the podcast? Start with the free guide, 10 Questions to Ask Your Doctor. https://health-with-hashimotos.kit.com/10-questions   READY TO SORT YOUR HASHIMOTO'S? Hashimoto's Decoded: Thyroid or Immune walks you through sorting everything into thyroid or immune, in under an hour, with a workbook to help you figure out your next step. https://healthwithhashimotos.com/hashimotos-decoded/   JOIN THE HEALTH WITH HASHIMOTO'S COMMUNITY Join the free Health with Hashimoto's community on Skool. It's a supportive space for women navigating Hashimoto's, and it's free to join. https://www.skool.com/health-with-hashimotos/about   Find all my other resources, including products and supplements I recommend, on my resource page: https://healthwithhashimotos.com/resources/   ABOUT THE PODCAST & ESTHER The Health with Hashimoto's podcast helps you sort your Hashimoto's into thyroid or immune, so you can finally understand what's happening in your body and what to do about it. Hosted by Esther Yunkin, a registered nurse and holistic health educator with 25 years of nursing experience. This podcast is for informational and educational purposes. Please discuss any questions or concerns with your healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure, or prevent any disease.

What if the reason you keep getting sick is not simply bad luck, seasonal viruses, or a string of unrelated health problems, but an immune system that has quietly become less effective over time?Most of us think of immune deficiency as a rare genetic condition discovered in childhood. But a far more common form can develop later in life.Because the symptoms often appear separately, patients may spend years moving between specialists without anyone asking the question that connects the entire picture: Is the immune system functioning the way it should?In this episode, we explore secondary immune deficiency and why it remains so easy to miss. Joining me is Dr. Fulvio Salvo, an internationally experienced allergist and clinical immunologist who has practiced at leading institutions in Italy, the United Arab Emirates, and Australia.He helps us understand how genetics, environment, nutrition, lifestyle, and modern medicine can intersect to strengthen (or gradually undermine) our immune defenses.What You'll Discover in This EpisodeWhy secondary immune deficiency is more common, and more easily overlooked than inherited immune disordersThe recurring infection patterns that should prompt a closer look at immune functionHow fragmented medical care can prevent clinicians from connecting seemingly unrelated symptomsThe basic tests a primary care physician can use to begin evaluating immune functionHow obesity creates an inflammatory environment that can disrupt immune regulation throughout the bodyWhat we currently know about GLP-1 medications and their effects on immunityWhy anti-inflammatory medications are not automatically immunosuppressiveWhy correcting a vitamin or mineral deficiency can help, while taking more than your body needs may offer no added benefitWhat makes zinc lozenges different from simply swallowing a zinc supplementThe three practical foundations of healthier immunity: lifestyle, vaccination, and knowing your own health historyAbout the GuestDr. Fulvio Salvo is an internationally respected expert in allergy and clinical immunology. He has trained and practiced at leading medical institutions around the world, including San Raffaele Hospital in Italy and Cleveland Clinic Abu Dhabi, and he now serves as a clinical immunologist and allergist in Cairns, Australia. Throughout his career, he has cared for patients with complex immune disorders while developing a unique global perspective on how genetics, environment, nutrition, lifestyle, and modern medicine influence immune health. Connect with Dr. Salvo on LinkedIn.About Your HostHosted by Dr. Deepa Grandon, MD, MBA, a triple board-certified physician with over 23 years of experience working as a Physician Consultant for influential organizations worldwide. Dr. Grandon is the founder of Transformational Life Consulting (TLC) and an outspoken faith-based leader in evidence-based lifestyle medicine.Work with MeLearn More About My Virtual Medical PracticeExciting news: my virtual medical practice is now open! I am currently seeing patients in Arizona, Connecticut, and Massachusetts, with additional states coming soon. If you live in one of these three states, you can schedule a consultation. If you live elsewhere, join the waitlist to be notified as availability expands.Precision care. Personalized guidance. Wherever you are.Feeling stuck and want guidance on how to transform your spiritual, mental, and physical well-being? Get access to Dr Deepa's 6 Pillars of Health video! Subscribe and watch the video for free here.Want to receive a devotional every week from Dr. Deepa? Devotionals are dedicated to providing you with a moment of reflection, inspiration, and spiritual growth each week, delivered right to your inbox. Subscribe now.Ready to deepen your understanding of trauma and kick-start your healing journey? Explore a range of online and onsite courses designed to equip you with practical and affordable tools. From counselors, ministry leaders, and educators to couples, parents, and individuals seeking help for themselves, there's a powerful course for everyone. Browse all the courses now to start your journey.

In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan welcomes renowned immunologist Dr. Isaac Melamed for a fascinating exploration of the immune system and its powerful influence on whole-body health, resilience, and longevity. Dr. Melamed explains why the immune system is far more than our defense against infections. Its intricate connections with the brain, nervous system, mitochondria, environment, and even our emotional experiences may help explain everything from autoimmunity and chronic pain to cognitive decline, Long COVID, allergies, and cancer. Together, they explore the emerging science of neuroimmunology, immune aging, IVIG, epigenetics, and a new vision for proactive "Immuno Wellness" focused on identifying dysfunction before it progresses into disease.

Host Amy Malek and Guest Betsy Miller engage in a fun and informative conversation about holistic strategies to help kids stay healthy as they head back to school. They cover the common concerns – immune support, focus, sleep, and anxiety. They discuss diet, supplements, and lifestyle routines to support an easy transition. Betsy shares strategies that work for her school age children, like creative methods for getting kids to take supplements, nutrient dense colorful whole food recipes, and how to encourage a healthy relationship with food. Betsy Miller is a Registered Herbalist and Certified Nutrition Specialist, and the manager of Clinical Product Support at Standard Process. Betsy specializes in nutrition and herbs for women's reproductive health, particularly fertility challenges, prenatal care and postpartum support. In addition to her work with Standard Process, Betsy adjunct faculty in the herbal medicine program at the School of Integrative Health at the Notre Dame Maryland University where she is also a clinical nutrition doctoral candidate. Podcast Summary 2:21 Supporting brain health and focus in school age children with supplements and whole food nutrition 5:24 Supplementing to fill nutrient gaps in children 7:44 Immune support for back-to-school 12:28 Choosing supplement formats and formulas designed for children 15:17 What to look for when choosing a pediatric multivitamin 17:52 Sleep hygiene for school age children including herbal remedies, routines, and lifestyle recommendations 23:11 Managing anxiety around social and academic concerns 26:28 The color of food and it's impact on immunity and overall health for kids 30:09 Cultivating a healthy relationship with food  

Immune reviews new research that shows a boost in T cell function after eating and the potential for the cGAS-STING pathway to be a new lupus therapeutic target. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server T cell immunity boosted after eating (Nature, 2026) Inhibiting autoimmunity through TLR7-cGAS (Nat Comm, 2026) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Show #2736 Show Notes: First Amendment: https://constitution.congress.gov/constitution/amendment-1/ Exempt: https://webstersdictionary1828.com/Dictionary/exempt Immune meaning in Law: https://search.brave.com/search?q=immune+in+law&conversation=097ca59692294150f83a0e803b8f28aecbc8 krytocracy: https://search.brave.com/search?q=krytocracy&spellcheck=0&conversation=097c0422d527a0ea175dc1029729b9fe761b Sabbath: https://webstersdictionary1828.com/Dictionary/sabbath Royce the “Black Queen”: https://x.com/Highway_30/status/2091982456450920693 Dave Daubenmire, a veteran 35 year high school football coach, was spurred […]

It's time to build your family's future on a foundation of true health and freedom. Join us at Future Foundations—because your future generations deserve the best start to the mission that will outlive us… Check it out here. Use code FREEDOM25 for 25% off!    Whether you're looking for tinctures, topicals or teas or a deeper connection to your INNATE healing capacity, Noble Task Homestead is here to serve you. Join the movement. Visit NobleTaskHomestead.com/noblestan today and enjoy a 10% discount on your order.   San Diego area residents, take advantage of our special New Patient offer exclusively for podcast listeners here. We can't wait to experience miracles with you!   Welcome to a new episode of the Future Generations podcast! Our guest today is Del Bigtree — Emmy-winning former CBS producer, founder of the Informed Consent Action Network (ICAN), and host of The Highwire. Del first rose to prominence as the producer of the documentary Vaxxed and has since become one of the most fearless voices in the health freedom movement. In this episode, delivered live on stage, Del breaks down what he calls the four critical problems with the COVID-19 vaccine: it doesn't stop infection or transmission, it triggered immune enhancement and animal deaths in every prior coronavirus vaccine trial, it may cause infertility in women through syncytin protein mimicry, and mass vaccination under suboptimal immune pressure could breed deadlier variants that reverse the natural evolution of viruses. Along the way, he shares the media strategy behind Vaxxed, his legal victories against the FDA and CDC, and a powerful call to action for truth, courage, and innate immunity.   Highlights: "This was never about your children. It was always about you."   "We are for the first time ever on the verge of reversing the evolution of viruses."   "Our unvaccinated children are not the pariah. They're not the scourge. Scientifically speaking, if Geert is right, they're our only hope."   "History is made by the brave. History is made by those people who have instinct, who have heart, and are fearless."   Timestamps: 1:52 Del Bigtree is introduced to the stage 5:52 Vaccines become the #1 headline in the world 6:22 The "no bad press" strategy behind Vaxxed 8:28 On the verge of a colossal blunder 13:52 "This was never about your children" 16:09 Problem 1: The vaccine doesn't stop infection or transmission 22:43 Problem 2: Immune enhancement and animal deaths in every trial 38:55 Problem 3: The vaccine may cause infertility in women 54:59 Problem 4: Mass vaccination could create an unstoppable deadly pathogen 1:11:03     "Our unvaccinated children are our only hope"   Resources:   Remember to Rate, Review, and Subscribe on iTunes and Follow us on Spotify!   Learn more about Dr. Stanton Hom on:   Instagram: https://www.instagram.com/drstantonhom    Website: https://futuregenerationssd.com/  Podcast Website: https://thefuturegen.com  Twitter: https://twitter.com/drstantonhom   LinkedIn: https://www.linkedin.com/in/stanhomdc   Stay Connected with the Future Generations Podcast:   Instagram:  https://www.instagram.com/futuregenpodcast   Facebook: https://www.facebook.com/futuregenpodcast/     About Del Bigtree: Del Bigtree is an Emmy Award-winning investigative journalist, television and documentary producer, and health freedom advocate. He is the CEO of the Informed Consent Action Network (ICAN), where he works to promote transparency, informed consent, and accountability in healthcare. He is also the Executive Producer of An Inconvenient Study, a documentary exploring questions surrounding modern healthcare and medical research.   Bigtree is the founder and host of The HighWire, an independent media platform covering health, medicine, vaccines, government policy, and individual rights. Through his journalism and advocacy, he has become a prominent and often outspoken voice in the health freedom movement, challenging conventional approaches to public health and encouraging people to question and examine the information presented to them. The desire to go off grid and have the ability to grow your own food has never been stronger than before. No matter the size of your property, Food Forest Abundance can help you design a regenerative layout that utilizes your resources in the most synergistic and sustainable manner. If you are interested in breaking free from the system, please visit www.foodforestabundance.com and use code "thefuturegen" to receive a discount on their incredible services.   Show your eyes some love with a pair of daylight or sunset (or both!) blue-light blocking glasses from Ra Optics. They have graciously offered Future Generations podcast listeners 10% off any purchase. Use code FGPOD or click here to access this discount, and let us know how your glasses are treating you!   One of the single best companies whose clean products have supported the optimal wellness of our family is Earthley Wellness. Long before there was a 2020, Kate Tetje and her team have stood for TRUTH, HEALTH and FREEDOM in ways that paved the way for so many of us. In collaboration with this incredible team, we are proud to offer you 10% off of your first purchase by shopping here.   Are you concerned about food supply insecurity? Our family has rigorously sourced our foods for over a decade and one of our favorite sources is Farm Match and specifically for San Diego locals, "Real Food Club PMA". My kids are literally made from their maple breakfast sausage and the amazing carnitas we make from their pasture raised pork. We are thrilled to share 10% off your first order when you shop at this link.   Another important way to bolster food security is by supporting local ranchers. Our favorite local regenerative ranch is Perennial Pastures. They have the best nutrient-dense meats that are 100% grass-fed and pasture-raised. You can get $10 off of your first purchase when you use the code: "FUTUREGENERATIONS" at checkout. Start shopping here.  

Stacy Horner discusses her work on innate detection of viruses, viral countermeasures, and the role of m(6)A RNA modifications in regulating antiviral immunity. Host: Cindy Leifer Guest: Stacy Horner Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Hepatitis virus proteases block host response (J Virol, 2012) Host RNA binds to MAVS (Science, 2024) m6A modifications modify innate response to viruses (Cell Chem Biol, 2024) UFMylation coordinates MAVS assembly for antiviral responses (bioRxiv, 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Candace Owens is declaring victory after her debate with Andrew Wilson—but did the debate actually prove any of her biggest claims? The Chicks break down the most explosive moments, including questions surrounding Charlie Kirk, Tyler Robinson, Israel, Erika Kirk, the evidence Candace says she has, and why the hosts think some of her answers created even more questions.Then, the conversation turns to mass immigration and assimilation as the hosts react to stories and viral clips involving Spain, Poland, Florida, Texas, airport prayer facilities, migrant services, food pantries, and the growing debate over how much immigration is too much.Plus, they cover the viral controversy surrounding an Israeli-American woman who says she was refused service at a salon after revealing she was Israeli, the salon owner's own recording of the encounter, and the potential consequences.And because Monday needs some laughs, the show wraps up with reactions to Hasan Piker, AOC, Gavin Newsom's unforgettable dance moves, Trevor the tuxedo dog, a dog absolutely terrified of a turtle, and the hilariously unhelpful Daisy.SUPPORT OUR SPONSORS TO SUPPORT OUR SHOW!Support your immune system with Healthy Cell's Immune's Super Boost. Visit https://HealthyCell.com/CHICKS and use code CHICKS20 to save 20% on your first purchase.Get 15% off OneSkin with the code CHICKS at https://Oneskin.co/ChicksSave an additional 10% off  practical food for your pantry with the ReadyWise 4-Can Protein Bundle at https://ReadyWise.com with promo code CHICKS10.Subscribe and stay tuned for new episodes every weekday!Follow us here for more daily clips, updates, and commentary:YoutubeFacebookInstagramTikTokXLocalsMore InfoWebsite

Most mayos, salad dressings and chips “made with 100% avocado oil” fail test; Borderline cholesterol—will a coronary calcium scan help decide whether a statin is warranted? Aged Garlic Extract for blood pressure; Immune benefits of BWH Beta Glucan. 

Get $50 Off Your Freedom Live Ticket: https://www.freedomlive2026.com Ready to break the patterns holding you back? Join the free live workshop: https://breaktheceiling2026.com The Mindset Mentor™ podcast is designed for anyone desiring motivation, direction, and focus in life. Past guests of The Mindset Mentor include Tony Robbins, Matthew McConaughey, Jay Shetty, Andrew Huberman, Lewis Howes, Gregg Braden, Rich Roll, and Dr. Steven Gundry. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.