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Gabrielle Rizzuto from Memorial Sloan Kettering Cancer Center discusses her work on the curious immunology of pregnancy and how a woman tolerates a genetically different baby but quickly rejects a mismatched organ donation. Host: Cindy Leifer Guest: Gabrielle Rizzuto Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Rizzuto lab at MSKCC Tolerance at the fetal-maternal interface (Nature, 2022) The paradox of fetal-maternal tolerance (J Exp Med, 2022) Spatially resolved timeline of fetal-maternal interface (Nature, 2023) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
ReferencesImmun Ageing. 2020; 17: 2.Trends in Immunology. 2017. REVIEW| VOLUME 38,ISSUE 4, P287-297, APRIL 01, Int J Mol Sci. 2025 Apr 27;26(9):4147Experimental & Molecular Medicine 2019. volume 51, Article number: 80 Beethoven, LV 1811. Piano Concert V in E Flat Major OP 73.https://music.youtube.com/watch?v=q-hn8WH_-3U&si=TNpna_2DZLIoX2nM
ReferencesSCIENTIFIC REPORTS 2016 | 6:34594 | DOI:10.1038/srep34594 Seminars in Immunology 2025. V. 78,Jun, 101954Front Immunol. 2025 Jan 8:15:1515715Telemann, GP. 1735. Sinfonia Spirituosa TWV 40&50https://open.spotify.com/album/2nJX3LIjdAbNIGR3qbQaBI?si=VF-7aHcBS_qOkEsl34LdKQ
ReferencesAntimicrob Agents Chemother. 2017 Dec 21;62(1):e01614-17Br J Cancer. 2002 Mar 18;86(6):963–970Science Translational Medicine 2019: vol. 11, Issue 501, 17 Jul Int J Mol Sci. 2025 Apr 27;26(9):4147 Fogerty, J 1969. Fortunate Son. CCRhttps://open.spotify.com/track/4BP3uh0hFLFRb5cjsgLqDh?si=5b6bd7dea0774f9dHunter/Garcia. 1973 It Must Have Been the Roses. Grateful Dead [Reckoning] lphttps://music.youtube.com/watch?v=tvXQ7r-n-Go&si=J6mTP9rquTHkNo-D
On this episode, Jared takes a deep dive into Biocidin, a practitioner-trusted botanical formula long used in functional and integrative wellness settings. Learn what makes this multi-herb blend unique and why it's often included in protocols designed to support oral health, gut health, immune resilience, and overall microbial balance. Jared explains biofilms in simple terms, why they matter for long-term wellness, and how botanical formulas like Biocidin are used to help maintain a balanced microbiome throughout the body. From the mouth and throat to the digestive tract and beyond, this episode explores real-world applications, research insights, and practical considerations for using multi-botanical support as part of a comprehensive wellness strategy. Part one focuses on education and understanding, while part two will cover how practitioners typically structure supportive protocols.Products:Biocidin and Dentalcidin ProductsVitality Radio POW! Product of the Week: Utzy Naturals Magnositol and Utzy Naturals Coll-U-Gen Get 35% off one bag or 45% off two or more bags (mix and match OK!) No Code Needed! (while supplies last)Additional Information:#555: From Gut to Gums: Mastering Microbial Balance Using Biocidin with Dr. Shawn Manske#617: Microbiome Balance from Mouth to Gut: Protocols for Clearing and Rebuilding with Biocidin – Part 2Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
Shaun broadcasts LIVE from Meridian Banquets in Rolling Meadows, IL ahead of President Trump's State of the Union address! PLUS, Shaun talks to Dr. Michael Huber, the creator of Virogo, about the natural health benefits of Virogo and how it fights back against everything (even Democrat air)! Use promo code IMMUNE to save 30%! And The Heritage Foundation's Simon Hankinson talks to Shaun about our imported Afghan problem and how President Trump is fighting illegal immigration by....enforcing the law!! See omnystudio.com/listener for privacy information.
ReferencesFront Immunol. 2015 Sep 28;6:493Guerra, DJ. Unpublished LecturesInt J Mol Sci. 2025 Apr 27;26(9):4147Biomolecules2019, 9(10), 513Vivaldi, A. 1715. The Great Venetian Masshttps://music.youtube.com/playlist?list=OLAK5uy_nz3Iy2f-mkA2jbas2npilpkSh3Db5l-wY&si=DesZSQv0ZBZcvrw-
Dr. Ronald Lane, Founder of HOPE-Neuron Therapeutx, is developing an approach to treating ALS by rebalancing the body's immune system, which becomes dysfunctional in neurodegenerative diseases. The mechanism involves treating a patient's blood outside the body to activate the immune system and then infusing it back into the patient. The theory is that traditional drugs often fail because they target static genetic mutations and symptoms, while the source of the disease lies in the ongoing immune imbalance. Ronald explains, "Well, in a broad sense, the goal of HOPE Neuron is based on the fact that our challenge here is to bring hope. And we use a neuronal basis to do that. We're not about drugs. There are no chemicals involved. We don't go that direction. But basically, it cuts across. We deal with memory, we deal with dementia and Alzheimer's, but our target initially is ALS." "As I mentioned a moment ago, we're not doing drugs, we're not using chemicals. So what are you doing? Well, we're using the cell's immune system, and the problem with disease is that the immune system gets out of balance. When it's out of balance, you become ill. It can be in many different diseases. And there are certain indicators, and we know what to look for and what compounds the body generates." #HOPENeuron #ALS #Neurology #ImmuneTherapy #MedicalInnovation #ALSResearch #Biotechnology #NeurodegenerativeDisease #MedicalBreakthrough #ClinicalTrials #Healthcare #Innovation #Neurodegeneration #Neuroplasticity #MedicalDevices #Immunotherapy #NeuroscienceInnovation #FutureOfMedicine #NonPharmaTherapies hopeneuron.com Download the transcript here
Dr. Ronald Lane, Founder of HOPE-Neuron Therapeutx, is developing an approach to treating ALS by rebalancing the body's immune system, which becomes dysfunctional in neurodegenerative diseases. The mechanism involves treating a patient's blood outside the body to activate the immune system and then infusing it back into the patient. The theory is that traditional drugs often fail because they target static genetic mutations and symptoms, while the source of the disease lies in the ongoing immune imbalance. Ronald explains, "Well, in a broad sense, the goal of HOPE Neuron is based on the fact that our challenge here is to bring hope. And we use a neuronal basis to do that. We're not about drugs. There are no chemicals involved. We don't go that direction. But basically, it cuts across. We deal with memory, we deal with dementia and Alzheimer's, but our target initially is ALS." "As I mentioned a moment ago, we're not doing drugs, we're not using chemicals. So what are you doing? Well, we're using the cell's immune system, and the problem with disease is that the immune system gets out of balance. When it's out of balance, you become ill. It can be in many different diseases. And there are certain indicators, and we know what to look for and what compounds the body generates." #HOPENeuron #ALS #Neurology #ImmuneTherapy #MedicalInnovation #ALSResearch #Biotechnology #NeurodegenerativeDisease #MedicalBreakthrough #ClinicalTrials #Healthcare #Innovation #Neurodegeneration #Neuroplasticity #MedicalDevices #Immunotherapy #NeuroscienceInnovation #FutureOfMedicine #NonPharmaTherapies hopeneuron.com Listen to the podcast here
David Kavanagh, MBChB, PhD, FRCP - A Clinically Considered Real-World Case Series: Practice Essentials From Biopsy To Diagnosis in Immune-Mediated Glomerular Diseases
Immune discusses how tattoo ink accumulates in lymph nodes, promotes inflammation and influences response to two different vaccines. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server IL-9, CAR T cells and anti-tumor CD8 cells Tattoo ink, inflammation and vaccines Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
ReferencesGuerra, DJ 2026. Unpublished LecturesThe Journal of Biological Chemistry 2018 293, 19001-19011 Int J Mol Sci. 2025 Apr 27;26(9):4147Cell Death & Disease 2019. v 10, Article number: 315 Hunter/Garcia/Kreutzmann. 1975 Franklin's Tower. Grateful Dead.https://open.spotify.com/track/3PgIhd4XmwtmV2XGU5qhzZ?si=7714f01313ca477bTravis, M. 1946. !6 Tons. Tennessee Ernie Fordhttps://open.spotify.com/track/3P6OwCX7Ofiaaqtvujb6i5?si=4b8704749b6e4390
What if the diet you've been following diligently — eating all the right things, tracking your macros, staying committed — is actually wrong for your specific biology? In this solo episode I share the anonymised case of a real client who gained eight kilograms following a ketogenic diet perfectly. Not because she was doing it wrong. Because her genetics made her one of the worst possible candidates for high saturated fat eating — and nobody had ever looked at her DNA. We go deep on the three specific genetic variants that predicted her poor response to keto, what her full microbiome mapping revealed that standard testing would have completely missed, and how her hormonal picture and chronic stress were silently driving the whole metabolic picture. This episode is for anyone who has tried hard, followed the advice, and still isn't getting results. It's time to stop blaming yourself and start looking at your biology. We cover why Instagram diet advice is genuinely dangerous for people with different genetics, what comprehensive functional testing actually looks like — DNA panels, microbiome mapping, DUTCH hormone testing, detailed bloodwork — and the universal dietary principles that apply to almost everyone regardless of their genetic profile. Your body is not broken. It just needs the right instructions. Find Lisa at lisatamati.com, shop supplements at shop.lisatamati.com, and try Rejuvenate Pro — our flagship Immune and gut health/longevity supplement — at https://shop.lisatamati.com/pages/rejuvenate Discover your immune age at myimmuneage.life Subscribe to my weekly longevity newsletter at lisatamati.com/lisa
You're taking 600 IU of vitamin D.Your labs say “normal.”But you could still be deficient. In this episode, Ben reveals why the official vitamin D recommendations were based on preventing rickets, not optimizing immunity, metabolism, muscle, or brain health. Independent researchers reanalyzed the original RDA data and found the required intake for adequacy was dramatically higher — yet the guidelines barely changed. Vitamin D is not just a vitamin. It functions like a steroid hormone and impacts: Immune regulation Inflammation control Insulin sensitivity Muscle protein synthesis Brain function Low vitamin D is strongly associated with insulin resistance, and since 93% of Americans are insulin resistant, this could be a massive blind spot. Ben also explains: Why “normal” lab ranges may still mean deficiency Why optimal levels should be above 60 ng/mL How obesity lowers circulating vitamin D Why magnesium and vitamin K2 are required for proper activation Why toxicity fears are overblown compared to widespread insufficiency You'll also learn the simple 3-step plan to optimize vitamin D safely: Smart midday sun exposure Intelligent supplementation with D3 + K2 + magnesium Regular testing and cofactor support If you're over 45, insulin resistant, or struggling with stubborn inflammation, this episode could be a game changer. You don't have a weak immune system.You may just have an under-supported one. Get 20% off with code FREEDOM at :https://bit.ly/46irN6O FREE GUIDE: The World's Easiest Breakfast Diet To Melt Fat HERE - https://bit.ly/4ryX1yC
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss reversal of last week's no review decision on a flu mRNA vaccine by Vinjay Prasad, appointment of Jay Bhattacharya as CDC director, no experience required, and already detectable reduction in hepatitis B virus vaccination rates, then Dr. Griffin then deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, how to access and pay for Paxlovid, the consequences of measles infection on immune amnesia (shout out to Immune 26), long COVID treatment center, where to go for answers to your long COVID questions, long COVID effect on fertility and type 2 diabetes and contacting your federal government representative to stop the assault on science and biomedical research. Click arrow to play Download TWiV 1298 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Whiplash! F.D.A. Reverses Decision and Agrees to Review Moderna's Flu Vaccine (NY Times, Wall Street Journal, Access New wire) N.I.H. Director Will Temporarily Run C.D.C. in Leadership Shake-Up (NY Times) Reduction in infant Hepatitis B Immunizations (Oregon State Health Department) Why Adenovirus vectored vaccine failed: Adenoviral Inciting Antigen and Somatic Hypermutation in VITT (NEJM) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard(South Carolina Department of Public Health) Measles Outbreak Hits Florida College (NY Times) Utah's measles outbreak reaches 300 cases (CIDRAP) Measles Is Actively Spreading in SLCo (Salt Lake County Health Department) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles(CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Measles 2025 (NEJM) Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens (Science; Immune 26) Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles (Science) Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands (Nature Communications) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Weekly surveillance report: cliff notes (CDC FluView) OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) US respiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) The risk of cardiac disease events after respiratory syncytial virus disease: a systematic literature review and meta-analysis (European Respiratory Review) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) COVID-19 Antiviral Prescription Receipt Among Outpatients Aged ≥65 Years (CDC: MMWR) Where to get pemgarda (Pemgarda) EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulation guidelines (hematology.org) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Assessing the impact of SARS-CoV-2 infection and vaccination on fertility and assisted reproductive techniques outcomes: an umbrella review (Vaccine) Long-Term Risk of Incident Type 2 Diabetes Following SARS-CoV-2 Infection: A Population-Based Study in British Columbia, Canada (Diabetes Metabolism Research and Review) Reaching out to US house representative Letters read on TWiV 1298 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.
"Because the premise of immune checkpoint blockade centers around elevating the immune function, we should always take a great deal of caution around those patients who have high immune risks. Those include patients with autoimmune disorders. That's one of our biggest questions that we ask, usually every consult that we're seeing with solid tumor. 'Do you have any history of autoimmune disorders? Tell me a little bit more about it. Is it being treated? What are your symptoms like?' And then also patients who have undergone organ transplants. Now, interestingly, this does include stem cell transplants," Kelsey Finch, PharmD, BCOP, oncology pharmacist practitioner at Columbus Regional Health in Indiana, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about checkpoint inhibitors. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by February 20, 2027. Kelsey Finch has disclosed a speakers bureau relationship with AstraZeneca. This financial relationship has been mitigated. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge related to checkpoint inhibitors in the treatment of cancer. Episode Notes Complete this evaluation for free NCPD. ONS Podcast™ episodes: Pharmacology 101 series Episode 273: Updates in Chemotherapy and Immunotherapy Episode 174: Administer Pembrolizumab Immunotherapy With Confidence Episode 139: How CAR and Other T Cells Are Revolutionizing Cancer Treatment ONS Voice articles: Here's Why Oncology Nurses Are Pivotal in Managing Immune-Related Adverse Events Make Subcutaneous Administration More Comfortable for Your Patients Nursing Considerations for ICI-Related Myocarditis Oncology Nurses Navigate the Changing Landscape of Immuno-Oncology Postdischarge ICI Patient Education Eliminates Hospital Readmissions Shorter Administration Times Still Require High-Acuity Care ONS Voice oncology drug reference sheets: Dostarlimab-Gxly Nivolumab and Hyaluronidase-Nvhy Nivolumab and Relatlimab-Rmbw Pembrolizumab and Berahyaluronidase Alfa-Pmph Retifanlimab-Dlwr Toripalimab-Tpzi ONS books: Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice (second edition) Guide to Cancer Immunotherapy (second edition) ONS course: ONS/ONCC® Chemotherapy Immunotherapy Certificate™ Clinical Journal of Oncology Nursing articles: Immune Checkpoint Inhibitor–Related Myocarditis: Recognition, Surveillance, and Management Immune Checkpoint Inhibitor Therapy: Key Principles When Educating Patients Triple M Syndrome: Implications for Hematology-Oncology Advanced Practice Providers ONS Huddle Cards: Checkpoint Inhibitors Immunotherapy ONS Learning Libraries: Genomics and Precision Oncology Learning Library Immuno-Oncology Learning Library Drugs@FDA package inserts National Comprehensive Cancer Network homepage OncoLink: All About Immunotherapy To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "Before immune checkpoint blockade, the two-year overall survival rate in metastatic melanoma was hovering around 10%. After these agents came to market, depending on the trial and the agents used, that number actually increased to about 50%–65%. So, five times the amount of patients were actually living at the two-year mark. Not surprisingly, studies then exploded across several tumor types, leading to approvals in all sorts of cancers, mostly in the solid tumor. But there are a couple hematologic as well. Lung cancer, kidney cancer, head and neck, Hodgkin lymphoma, hepatocellular, the list goes on. So, it's really just transforming the stage IV setting across all tumors, specifically from uniformly fatal prognosis to one where durable responses and long-term survival is also possible." TS 3:03 "There are four different mechanisms officially being used in therapies that are approved by the U.S. Food and Drug Administration (FDA). Those are cytotoxic T-lymphocyte–associated protein 4, programmed cell death protein 1, and programmed cell death ligand 1, which I'm counting as two different mechanisms, even though they somewhat work together. And lymphocyte-activation gene 3 is the fourth one that's in there. So, all these mechanisms impact the T cell in our immune system. The T cell is traditionally responsible for protecting our body from harmful things like bacteria, viruses, and cancer. When the tumor binds to cytotoxic T-lymphocyte–associated protein 4 receptors, that happens on the T cell itself. And that inhibits the activation of the T cells, essentially allowing that tumor to then live. So when developing medications that block this receptor, they noted an added benefit that it actually increased the T-cell proliferation as well as keeping that T cell active. So not only are we not blocking the T cells, we're making them more productive." TS 5:38 "If you have a chance of any sort of tissue rejection, specifically with allogeneic stem cell transplants or where we see that focusing on it, there's a little bit of controversy, mixed bag on opinions as far as autologous stem cell transplants. But it's best to at least exercise a little bit of caution. If they have a chance of organ rejection, is that worth the risk of the therapy that we're looking to give? And then, patients with HIV, any sort of immunologic concerns at baseline that we could potentially worsen." TS 14:37 "As a rule of thumb, with immune checkpoint blockade, regardless of what mechanism you're looking at, if something in your body can get inflamed, that can wind up as an adverse event. So, whenever I talk to my patients, the key word is anything ending in '-itis.' ... The most common adverse events that we end up seeing are dermatitis and hypothyroidism. Immune checkpoint blockade can cause both hyper- and hypothyroidism. Very often, we actually start in the hyper- and then end up, for lack of better words, burning out the thyroid, ultimately leading to a sustained hypothyroidism." TS 18:34 "The half-life of immune checkpoint inhibitors is usually around 30 days, meaning that once these agents are given, the drug will be in the patient's system for up to five months. Specifically, it will probably build month to month, so often we don't even see a lot of our adverse events until month three or four. Usually, when we're that far into treatment, we're not looking for new adverse events in things like chemotherapy. But these drugs do build over time." TS 24:28 "As far as safe handling is concerned, these agents are not chemotherapy. That makes drug compounding and administration pretty straightforward. When looking at the follow-up care, the most important thing, in my opinion, is to engage in meaningful dialogue with your patients. A lot of the side effects can be nonspecific. So, really listening to the patient and evaluating changes in their lifestyle, I think it'll get you far. We usually hark in on the new, worsening, or persistent whenever we're talking to patients because they'll be looking for things as well. So, just having a dialogue of how their life has changed can certainly help." TS 26:17
Send a textIn this episode of The Autoimmune RESET Podcast, I'm sharing some of the key ideas from a full-day practitioner training I recently delivered on arthritis — and why the way we think about joint pain needs to change.For decades, arthritis — particularly osteoarthritis — has been framed as a simple story of wear and tear. Something mechanical. Something inevitable. Something that happens as we age.But that explanation is incomplete.Joint health is not just about cartilage. It is about the immune system, the gut, the nervous system, metabolism, and the body's ability to resolve inflammation. Arthritis is often a systemic condition that happens to be expressed through the joints.In this episode, we explore the deeper physiology behind inflammatory joint symptoms, including:• The gut–joint connection and intestinal permeability • Microbial triggers linked to autoimmune arthritis • The role of short-chain fatty acids and immune tolerance • Omega-3 fatty acids and the resolution of inflammation • Why digestion and absorption are often overlooked foundations • Nervous system regulation and pain signalling • The importance of sequencing interventions rather than doing everything at onceI also share reflections from my own experience of living with significant joint pain for many years, and what I've learned from working with clients who move from daily inflammation and limitation to meaningful recovery.One of the most important messages in this episode is that healing rarely happens through quick fixes. It happens through a layered, strategic approach — stabilising foundations first, then building resilience over time.If you are living with joint pain, stiffness, autoimmune arthritis, or inflammatory flares, this conversation will help you understand why your symptoms may be happening and what you can begin to do about them.Because arthritis is not always inevitable. And it is very rarely just about ageing.arthritis, autoimmune disease, gut health, inflammation, omega-3, digestion, nervous system, joint pain, immune regulation, functional medicine
BUFFALO, NY — February 19, 2026 — A new #research paper was #published in Volume 18 of Aging-US on February 8, 2026, titled “Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV.” In this study, co-first authors Alan Tomusiak from the Buck Institute for Research on Aging and the University of Southern California, and Sierra Lore from the Buck Institute for Research on Aging and the University of Copenhagen, together with corresponding author Eric Verdin from the Buck Institute for Research on Aging, developed a new single-cell transcriptomic clock called T immune cell transcriptomic clock (Tictock) to measure aging in specific immune cells. Immune aging increases susceptibility to infection, cancer, and chronic inflammatory disease. Most aging clocks, used to measure it, rely on bulk measurements from mixed cell populations. As a result, they cannot determine whether age-related signals reflect shifts in cell proportions or true molecular aging within defined immune cells. To address this limitation, the research team used single-cell RNA sequencing, a method that measures gene expression in individual cells. They analyzed nearly two million immune cells from the blood of healthy adults to develop Tictock. This tool integrates automated classification of six canonical T cell subsets with cell-type specific age prediction models. This design enables the separation of systemic aging, reflected by changes in cell proportions, from intrinsic aging, which occurs within individual cells. When the team applied Tictock to patients with acute COVID-19, they found two clear effects. First, COVID-19 altered T cell composition, including significant reductions in naïve CD8 and naïve CD4 T cells. Second, the infection increased the biological age of naïve CD8 T cells. In people living with HIV who were receiving long-term antiretroviral therapy, T cell proportions remained largely stable. However, naïve CD8 T cells still showed signs of accelerated aging. The study also uncovered shared biological pathways linked to immune aging. Many of the genes that predicted age were involved in ribosomes, the structures that help cells produce proteins. The researchers also observed that older immune cells often had shorter average transcript lengths, a feature previously linked to aging. These findings suggest that changes in protein production and gene regulation play an important role in immune decline. “Gene Ontology enrichment of 209 genes shared across six clock models identified common pathways including the cytosolic small ribosomal subunit, TNF receptor binding, and cytosolic ribosome components.” Overall, Tictock was designed to measure relative aging within defined T cell populations rather than overall biological aging. By distinguishing systemic from cell-intrinsic immune aging, it provides a clearer understanding of how viral infections such as COVID-19 and HIV reshape immune function. This approach enables the study of immune aging at single-cell resolution and may support improved immune risk assessment in clinical and research settings. DOI - https://doi.org/10.18632/aging.206353 Corresponding author - Eric Verdin - EVerdin@buckinstitute.org Abstract video - https://www.youtube.com/watch?v=_r3AF7OrgKY Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com. MEDIA@IMPACTJOURNALS.COM
Mark sits down with Joel Greene to unpack the sugar diet—why it can work short-term (hello, glycolysis), what it may shift long-term (gut taxa + immune cell metabolism), and why the body isn't a “static machine.” They also hit insulin sensitivity, keto/carnivore blind spots, the “calorie is a calorie” debate, and why rhythms/pulses beat doing the same thing daily.Special perks for our listeners below!
Is the brain really the source of mind — or is consciousness something more deeply biological?In this conversation, Anna Ciaunica challenges neurocentrism and explores the idea that cognition may not begin with neurons at all. We examine neuroimmune coupling, pregnancy as a nested model of subjectivity, basal intelligence before brains, and the fragile embodied self revealed in depersonalization experiences.We also explore biological idealism, multiscale intelligence, and whether artificial systems can ever replicate the ontological structure of living organisms.Topics include:• Neurocentrism and its limits• Immune systems as fact-checkers for survival• Basal cognition before neurons• Pregnancy and nested subjectivity• The fragile embodied self• Depersonalization & active inference• Touch and self-other boundaries• Biological idealism explained• Ontological differences between AI and life• Multiscale intelligence and self-organizationThis episode moves from cells to selves to artificial systems — and asks whether experience might be more fundamental than we assume.TIMESTAMPS:(0:00) – Introduction & The Challenge to Brain-Centrism(4:33) – Philosophy's Role in Questioning Scientific Assumptions(8:47) – Neuroimmune Coupling & The Origins of Thought(14:56) – Pregnancy, Nested Systems & Cellular Perception(17:18) – Embodiment in Early Development(23:47) – Phenomenal vs Grounded Experience(29:46) – Fetal Sensory Processing & Early Cognition(36:20) – Layered Analogies for Cognition(40:09) – Basal Intelligence Before Neurons(46:24) – Soma-Sema Theory & Death Anxiety(51:23) – Birth, Death & Ontological Boundaries(55:25) – Depersonalization & The Fragile Self(1:03:39) – Cracks in Transparency & Self-Perception(1:10:50) – Touch, Interaction & Self-Other Boundaries(1:16:45) – The “No Body” Problem(1:21:08) – Brain ≠ Mind: The Neuroimmune Challenge(1:29:09) – Biological Idealism Explained(1:37:59) – AI vs Biological Ontology(1:46:43) – Hidden Assumptions in AI Discourse(2:00:05) – Final ThoughtsEPISODE LINKS:- Anna's Website: https://annaciaunica.fr/- Anna's X: https://x.com/AnnaCiaunica- Anna's Bluesky: https://bsky.app/profile/annaciaunica.bsky.social- Anna's Publications: https://scholar.google.com/citations?user=ZUMz7EAAAAAJ&hl=en- From Cells to Selves: https://aeon.co/essays/why-you-need-your-whole-body-from-head-to-toes-to-think- When The Self Slips: https://aeon.co/essays/what-can-depersonalisation-disorder-say-about-the-selfCONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@MindBodySolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.
Send a textIn this episode of Never Been Sicker, Michael Rubino talks with Dr. Alex, a chiropractor who approaches chronic symptoms through immune response, nervous system function, nutrition, and environmental triggers. They unpack common root causes behind headaches, brain fog, fatigue, hormone issues, and histamine imbalance, plus why so many people are told “your labs look normal” while still feeling awful.They also explore how mold exposure can affect different people in the same home in completely different ways, why fixing the environment is often step one, and how detox should start with foundational pathways like digestion, hydration, sweating, and lymphatic support. Dr. Alex shares how he uses testing to personalize protocols and why there should always be a plan, not just a prescription.If you are dealing with chronic symptoms, suspected mold exposure, histamine issues, or fertility concerns, this conversation will help you understand what to look at next.00:00 Intro: Michael welcomes Dr. Alex00:30 Dr. Alex background: pain, spine, neuro issues, immune response01:30 Why people seek help and why symptom chasing fails02:10 Headaches: structural causes vs histamine and hormones03:00 Histamine explained in simple terms and why it matters04:20 Why Dr. Alex moved into a functional approach05:30 Chronic inflammation from “healthy” foods and hidden triggers07:10 “Test, do not guess” for the body and the home09:00 Never Been Sicker: rising prescriptions and chronic illness10:10 Why chiropractors do not prescribe and the herbal foundation11:20 “Where is the plan to get people off meds?”13:00 No quick fixes: the effort required to actually heal15:20 Nutrition confusion and why bio individuality wins16:30 Same house, different symptoms: immune response differences19:20 Environmental toxins are involved for most patients21:00 Michael explains hidden mold drivers and building science basics23:00 Why you cannot heal fully while still living in exposure24:05 Infertility, hormones, and mold disruption26:00 Using the Dust Test and pairing it with body testing28:00 How Dr. Alex realized mold was part of stubborn cases31:15 Biggest lie: “You'll be on meds for life” and “labs are normal”36:00 Care matters: rushed appointments vs real root cause time38:30 Detox foundations: lymph, hydration, movement, sweating40:45 Why random binders can backfire if pathways are blocked43:00 Controversies: normalizing toxins, fluoride, root canals45:00 Where to find Dr. Alex and his practice-----------------------------------------------------------------------------------------------
America Out Loud PULSE with Dr. Myriah Hinchey – Dr. Crista clarifies the critical distinction between common environmental molds and the dangerous conditions associated with water-damaged buildings, where mycotoxin-producing species can thrive and create a chronic inflammatory burden on the body. Together, they discuss how exposure can occur not only through inhalation but also through...
Anna Beaudin from University of Utah talks about the key thread of her career, development, and how that influences her research on the events happening during critical prenatal windows shapes everything from the developing immune system to hearing loss. Host: Cindy Leifer Guest: Anna Beaudin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Beaudin lab at University of Utah PhD work on metabolism and development Postdoc work on hematopoietic stem cells Maternal inflammation and hematopoietic stem cell development Prenatal inflammation effect on postnatal immunity Early life inflammation and hearing loss Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
America Out Loud PULSE with Dr. Myriah Hinchey – Dr. Crista clarifies the critical distinction between common environmental molds and the dangerous conditions associated with water-damaged buildings, where mycotoxin-producing species can thrive and create a chronic inflammatory burden on the body. Together, they discuss how exposure can occur not only through inhalation but also through...
Sony has accomplished a truly rare feat in this contentious era by providing players with a widely-lauded hour-plus State of Play presentation. At the top of the heap of announcements for many are a duo of God of War-related unveilings -- the long-rumored 2.5D Metroidvania game and an early-in-development ground-up remake of the original PS2 and PS3 trilogy -- with the former project stealth released at the time of its reveal. That's right: You can buy it right now! 29 other games were showcased, revealed, and otherwise shown off during the proceedings as well, like a new Castlevania called Belmont's Curse, a sequel to Kena: Bridge of Spirits called Scars of Kosmora, a AAA John Wick project, stealth title Yakoh: Shinobi Ops, the second volume of Konami's Metal Gear Collection, and much, much more. Plus, fresh looks at Saros, Resident Evil: Requiem, Marathon, Mina the Hollower, Beast of Reincarnation, Marvel Tokon, Control Resonant, Pragmata, 4LOOP, and so on. Other news rounds things out this week -- like steep layoffs at Highguard studio Wildlight and casting details for 2027' Helldivers film -- before we move onto listener inquiries. Who are some of our favorite black characters in gaming history? Why exactly doesn't Colin care about sports games anymore? Should Sony more heavily pursue Astro Bot spinoffs? Did the all-Spanish Super Bowl Halftime Show send any of us into an unspeakable rage? Get 50% off your first box and free breakfast for a year at https://www.factormeals.com/sacred50off and use code sacred50off Sign up for your $1 per month trial period at https://www.shopify.com/sacred Please keep in mind that our timestamps are approximate, and will often be slightly off due to dynamic ad placement. 0:00:00 - Intro0:28:09 - Love to Sean0:35:17 - Superbowl thoughts0:52:00 - GTA regret after murder0:57:09 - State of Play1:05:20 - Kena: Scars of Scars of Kosmora1:10:20 - Ghost of Yotei: Legends1:16:04 - Death Stranding 2 PC1:18:46 - 4:Loop1:26:26 - Capcom updates1:27:08 - Legacy of Kain Defiance Remastered1:29:41 - Brigandine1:31:45 - Dead or Alive1:33:16 - Control Resonant1:35:11 - Crimson Moon1:37:28 - Beast of Reincarnation1:39:58 - Rayman 30th Anniversary Edition1:44:21 - Mina the Hollower1:45:39 - Yakoh Shinobi Ops1:48:27 - Project WIndless1:53:36 - Star Wars Galactic Racer1:58:15 - Metal Gear Solid Collection Vol 22:02:42 - Konami segment2:14:47 - John Wick2:18:33 - Marathon2:21:44 - Saros2:22:18 - Tokon2:24:18 - God of War2:37:36 - Highguard layoffs3:17:22 - Horizon 3 could be 3-5 years out3:29:43 - Kojima revealed he almost worked with Respawn3:38:21 - Build A Rocket Boy still claims they were sabotaged3:53:22 - Helldivers movie update3:58:15 - What We're Playing (Lovish, Astalon: Tears of the Earth, Turok 2: Seeds of Evil, Resident Evil 5, Dragon Quest VII: Reimagined)4:22:16 - PlayStations online negativity4:29:25 - Black History Month in gaming4:34:24 - Returning to Madden?4:35:49 - Women in the industry4:41:20 - Should Sony focus on uncslop?4:43:40 - Where are the Astrobot spinoffs? Learn more about your ad choices. Visit podcastchoices.com/adchoices
This is episode 76 of the Love, Hope, Lyme podcast. To get your free pdf of "Love, Hope, Lyme: What Family Members, Partners, and Friends Who Love a Chronic Lyme Survivor Need to Know," reach out to Fred Diamond on social media. [NOTE: This podcast does not replace medical treatment. If you struggle with Lyme care, please see a Lyme Literate Medical Doctor.] In this episode of the Love, Hope, Lyme Podcast, Fred Diamond, author of "Love, Hope, Lyme: What Family Members, Partners, and Friends Who Love a Chronic Lyme Survivor" sits down with Dr. Jennifer Miller, who oversees clinical and scientific operations at Galaxy Diagnostics, for one of the most important conversations we've ever had about Lyme disease. We discuss the basics. Not just what Lyme does, but why it happens in the first place. Dr. Miller brings decades of deep scientific experience studying Borrelia burgdorferi and explains: ✅ How ticks actually become infected ✅ Why nymph ("seed") ticks are the biggest threat to humans ✅ What happens biologically inside the tick and inside your body ✅ Why Borrelia is so hard for the immune system (and antibiotics) to find ✅ How co-infections like Bartonella and Babesia complicate diagnosis and recovery ✅ Why some people develop neurological symptoms while others don't ✅ Why today's antibody tests often miss active infections and how Galaxy is working on direct detection methods to change the standard of care We also talk about:
We had the best time catching up with our bud Barrett Jones down in Florida—talking about his past year, what's on the horizon, and making it official that his new band The Immune is officially official
Botox toxicity. Breast implant illness. Immune system reactivity. Post-COVID inflammation. In this episode of The Health Revival Show, we break down the real science behind cosmetic procedures and why some people tolerate Botox and breast implants perfectly… while others develop systemic symptoms. We cover: • How Botox works as a neurotoxin • Breast implant illness vs immune reactivity • Terrain theory and why host health matters more than exposure • Genetic detox pathways and inflammatory risk markers • Mast cell activation, histamine intolerance, and post-viral sensitivity • When cosmetic procedures are lower risk — and when to wait If you've ever wondered whether Botox or implants are “toxic”… this conversation will change how you think about risk, immunity, and personalized health decisions. *** CONNECT:
Two-year study reveals the startling impact that playing in nature has on children's immune systems, and their likelihood of developing allergies and diseases such as asthma and diabetes. Researcher Marja Roslund talks about the dramatic changes they measured in children's ability to fight off illnesses and the reduction in harmful bacteria found in their gut, after they rewilded the children's daycare centres, bringing in soil, plants and even a section of forest floor. She also explains the causal link between the explosion in allergies and conditions such as asthma and diabetes, and the changes we can make to make a difference. Learn more about your ad choices. Visit podcastchoices.com/adchoices
In this episode, we review the high-yield topic of Small Vessel Vasculitides without Immune Complexes from the Cardiovascular section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode of Dr. Osborne's Zone, we'll explore powerful natural remedies to fight off colds and flu, especially during the peak of flu season. I will share essential tips on early intervention when symptoms like sore throats appear, recommending hydrogen peroxide, salt, and hydrolyzed silver to kickstart healing. Discover the benefits of natural ingredients like licorice root and essential oils in alleviating symptoms and boosting immune health. I'll also explain how to manage fever effectively, using natural alternatives like white willow bark for pain relief, while emphasizing the importance of a nutrient-dense diet and the role of protein in strengthening immunity.My Ultimate Immune Protocol: https://www.glutenfreesociety.org/dr-osbornes-ultimate-immune-protocol/Supplements mentioned in this show:Virid - http://glutenfreesociety.org/ViridUltra Sinus Support - https://glutenfreesociety.org/UltraSinusSupportUltra D3 - http://glutenfreesociety.org/UltraD3Ultra A - http://glutenfreesociety.org/AlphaMaxUltra Zinc - http://glutenfreesociety.org/UltraNACUltra NAC - http://glutenfreesociety.org/UltraNACGluten Sensitive? Take the quiz & Join Our Community ▶https://www.glutenfreesociety.org/gluten-sensitivity-intolerance-self-test/Get my quick start guide on going gluten free: https://www.glutenfreesociety.org/how-to-go-gluten-free/Nutritional Crash Courses Playlist: https://www.glutenfreesociety.org/nutritionGet Gluten Free Supplements: https://www.glutenfreesociety.org/shop-home/No Grain No Pain the Book: https://www.glutenfreesociety.org/NoGrainNoPainGlutenology Masterclass (Ultimate Guide): https://glutenology.net/registrationTo connect with Dr. Osborne visit:On the web: https://drpeterosborne.com/Facebook: https://www.facebook.com/DoctorPeterOsborne/TikTok: https://www.tiktok.com/@drpeterosborneInstagram: https://www.instagram.com/drosborneTwitter: https://twitter.com/glutenologyPinterest: https://www.pinterest.com/docosborne/Podcast:Apple Podcasts: https://podcasts.apple.com/us/podcast/dr-osbornes-zone/id1706389688?uo=4Spotify: https://open.spotify.com/show/4Zdf07GgpRAVwlSsYvirXTAmazon Music/Audible: https://music.amazon.com/podcasts/20d71b2e-3554-4569-9d5b-4259785cdc94Google Podcasts: https://www.google.com/podcasts?feed=aHR0cHM6Ly93d3cuc3ByZWFrZXIuY29tL3Nob3cvNTkwNjcwNC9lcGlzb2Rlcy9mZWVkiHeart Radio: https://iheart.com/podcast/119388846Dr. Peter Osborne is one of the most sought after alternative and nutritional experts in the world. A Diplomate with the American Clinical Board of Nutrition, a graduate of Texas Chiropractic College, and a doctor of pastoral science, Dr. Osborne is one of the world's leading authorities on gluten, nutrition, and natural health. He is the founder GlutenFreeSociety.org, one of the world's largest informational sites on gluten sensitivity. In addition, he is the author of the best selling book, No Grain No Pain, published by Touchstone (Simon & Schuster). His work has been featured by PBS, Netflix, Amazon, Fox, U.S. News, Ney York Post, and many other nationally recognized outlets.For collaborations please email: glutenology@gmail.comAny information on diseases, treatments, nutrition, or other health related topics from this channel are for educational purposes only, and should not be considered a substitute for advice provided by your doctor or healthcare provider. Bottom line...if you have health issues, you should always seek professional medical guidance.Products and supplements discussed in this video have not been evaluated by the FDA. They are not intended to treat, cure, or diagnose. Dr. Osborne is an Amazon affiliate, and many earn from qualifying purchases. For more information, visit us at https://www.glutenfreesociety.org/ or call 281-903-7527
In this episode:00:46 The immune cells that eat waste fats from fruit flies' brainsNature: Cho et al.10:21 Research HighlightsNature: Beetle is locked into an eternal dance ― with an antNature: Super-sniffer aeroplane finds oil fields' hidden emissions12:41 Ancient DNA evidence reveals a nuanced story of the Bell Beaker ExpansionNature: Olalde et al.Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.
Can fasting actually weaken cancer — and make chemotherapy work better?In this episode of Integrative Cancer Solutions, Dr. K sits down with longevity and nutrition science pioneer Dr. Joseph Antoun to break down the emerging research on fasting, fasting-mimicking diets, and precision nutrition for cancer. Dr. Antoun explains why cancer thrives on growth signals, how traditional “eat more calories” advice may backfire, and what the science really says about starving cancer while protecting healthy cells.This conversation explores fasting-mimicking nutrition before chemotherapy, immune rejuvenation, autophagy, growth factors like insulin and IGF-1, muscle preservation, and why food-as-medicine may dramatically improve treatment tolerance and outcomes. If you or someone you love is navigating cancer — or wants to reduce risk through longevity-based nutrition — this episode delivers critical, science-backed insights you won't hear in a standard oncology visit.Key Takeaways:0:00 Introduction and why nutrition matters in cancer6:10 Starving cancer while protecting healthy cells9:20 Fasting-mimicking diets vs water fasting12:45 How fasting sensitizes cancer to chemotherapy16:30 Immune system rejuvenation and autophagy explained21:00 Nutrition strategies after cancer treatment for longevityResources Mentioned:L-Nutra / ProLon® Fasting Mimicking Diet - https://www.l-nutra.comL-Nutra Health – Diabetes & Nutrition Programs - https://www.lnutrahealth.comThe Longevity Diet by Valter Longo - https://www.valterlongo.comCREATE Cures Foundation (USC Longevity Clinics) - https://createcures.org -----------------------------------------------A Better Way to Treat Cancer: A Comprehensive Guide to Understanding, Preventing and Most Effectively Treating Our Biggest Health ThreatGrab my book here: https://www.amazon.com/dp/B0CM1KKD9X?ref_=pe_3052080_397514860 Unleashing 10X Power: A Revolutionary Approach to Conquering CancerGet it here: https://store.thekarlfeldtcenter.com/products/unleashing-10x-powerPrice: $24.99100% Off Discount Code: CANCERPODCAST1 Healing Within: Unraveling the Emotional Roots of CancerGet it here: https://store.thekarlfeldtcenter.com/products/healing-withinPrice: $24.99100% Off Discount Code: CANCERPODCAST2-----------------------------------------------Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com
Leslie Berg talks about her career studying T cell receptor signaling, T cell development, and the importance of mentors in her career. Host: Cindy Leifer Guest: Leslie Berg Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Berg lab at University of Colorado Anschutz TCR thresholds and ITK (PNAS) Review on TCR signaling (Nat Immunol) Generation of TCR transgenic mice (Mol Cell Bio) T cell negative selection in TCR transgenic mice (Nature) Thymic exit of mature T cells in TCR transgenic mice (Cell) AAI past president Berg information Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
In this episode, we review the high-yield topic of Small Vessel Vasculitides without Immune Complexes from the Cardiovascular section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
On this episode of Vitality Radio, Jared sits down with returning guest Jamie Cotter, national educator for WishGarden Herbs, to break down immunity in a way that actually makes sense. Instead of treating the immune system as a one-size-fits-all problem, Jamie explains the four distinct phases of immunity—daily immune maintenance, early onset, active illness, and recovery—and why each phase benefits from a different herbal strategy. You'll learn how tonic herbs support baseline immune resilience, why timing and dosing matter when symptoms first appear, and how targeted herbal formulas can support the body during active immune challenges and lingering recovery phases. This episode empowers listeners to better understand their own immune responses and make informed choices about herbal support, seasonal wellness routines, and immune preparedness—without fear, hype, or guesswork.Products Discussed:Daily ImmuneKick-Ass ImmuneSerious V-FighterDeep LungKick-Ass BioticGet Over It!Buy 4 or more Wishgarden products from HERE and get 25% off through March 7, 2026!Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
Featuring perspectives from Dr Hanny Al-Samkari, Dr Cindy Neunert and Prof Francesco Zaja, including the following topics: Introduction (0:00) Case: A woman in her early 30s with chronic relapsing immune thrombocytopenia (ITP) receives eltrombopag with ongoing stabilization of platelet counts — Neil Morganstein, MD (2:03) Case: A woman in her late 60s with a long history of ITP controlled by eltrombopag experiences acute exacerbations — Bhavana (Tina) Bhatnagar, DO (6:42) Clinical Manifestations and Initial Management of ITP — Dr Neunert (18:07) Case: A woman in her early 80s with metastatic adenocarcinoma of the lung who responded to carboplatin/pemetrexed/pembrolizumab presents with ITP after 14 months of maintenance pembrolizumab — Susmitha Apuri, MD (33:14) Incorporation of Thrombopoietin Receptor Agonists and Other Second-Line Therapies into ITP Management — Prof Zaja (40:19) Case: A woman in her late 60s with stress cardiomyopathy and corticosteroid-refractory ITP receives rituximab followed by eltrombopag — Eric Fox, DO (1:00:44) Current and Future Role of Novel Therapies in ITP — Dr Al-Samkari (1:03:47) CME information and select publications
Dr Hanny Al-Samkari from Massachusetts General Hospital in Boston, Dr Cindy Neunert from Columbia University Irving Medical Center in New York and Prof Francesco Zaja from ASUGI in Trieste, Italy discuss cases of immune thrombocytopenia and recent findings from the 2025 ASH Annual Meeting.CME information and select publications here.
Join our free community, The Women's Peptide Collective, click the Skool link to become a member and to connect, learn, and collaborate. https://www.skool.com/womens-peptide-collective-9663Go to https://thepeptique.com/ to get all your research peptides .As a loyal listener use the discount code POD15 to get 15% off the entire line of products.Have questions? Feel free to reach out to me: tarawest@westwellnessatx.comWant the free peptide guide? Email me tarawest@westwellnessatx.com and comment Guide and I'll shoot it right over!Follow me on instagram AND TikTOk @westwellnessatxStay in touch add your email to the list ! https://form.jotform.com/25336471779006TakeawaysThe podcast discusses the impact of VIP peptide on systemic health, emphasizing its regulatory functions across various bodily systems.VIP peptide is recognized for its significant role in managing chronic inflammation and immune responses, addressing root causes rather than merely symptoms.The speaker shares personal experiences with VIP peptide, detailing its effects on energy levels, mood regulation, and overall well-being after usage.The episode explores VIP's capacity to enhance gastrointestinal health, emphasizing its importance in healing and maintaining gut integrity.Listeners are encouraged to consider VIP peptide as a potential adjunct treatment for various health issues, while consulting with healthcare professionals for individualized advice.
Forever Young Radio Show with America's Natural Doctor Podcast
DHEA was first identified in 1931 by Dr. Adolf Butenandt, who was awarded the Nobel Prize for Chemistry in 1939. Frequently called “the anti-aging hormone”, DHEA is a base for more than 50 hormones that are smaller or more specific carbon chain molecules in human biochemistry. As a precursor for all estrogenic and androgenic hormones, humans make DHEA naturally from birth.It's now well established that chronic stress leads to an out-pouring of cortisol and with that, a gradual depletion of DHEA. DHEA is a prohormone – a natural building block for hormones our bodies make.Over time, this hormonal imbalance can lead to brain fog, thinning bones, weight gain, low sex drive and poor Immune function.Maintaining proper DHEA levels in the body is important to your overall health and may lead to Increased energy, enhanced mood and focus, sound sleep, and better letting skin.Guest: Joining us today is Hugh Woodward, He is the President of Health2Go, Inc the makers of Twist 25 DHEA cream. Hugh is a subject matter expert on DHEA dedicating nearly 2 decades of his life studying the medical research about it, and starting a company to research, develop the safest most effective DHEA supplement that can be made and distributing it.In 2007 Mr. Woodward started Health2Go, Inc. to research and develop leading edge anti-aging and wellness products and bring them to people conveniently and cost effectively.Quality matters when supplementing with DHEA.Twist 25 DHEA Cream puts exactly what the body makes naturally – bioidentical DHEA -in the skin, where the body processes DHEA. As a base building block for hormones, DHEA gives the body a key foundation it uses to make hormones, (especially the androgens our feel-good hormones.)Visit Twist25.com to learn more and order online. Or call 888-489-4782 that's888-489-4782. Look your best feel your best with Twist 25 DHEA creamthat's twist25.comListeners can save 10% OFF using the code: forever at checkout.Helpful Articles
How can we avoid burning out so quickly? How do we keep the immune system at full strength?
You've balanced your blood sugar. You've worked on your gut. You've supported your hormones. So why do you still feel exhausted, inflamed, and stuck? In this episode, we're talking about a massive missing piece in both conventional and holistic care: the load your body is carrying. Foundations don't collapse randomly—they collapse because they're under pressure. We unpack how toxic burden and immune burden quietly drain your energy, disrupt hormones, and keep your nervous system stuck in high alert—even when your labs look "normal." This conversation will help you understand: Why doing more isn't always the answer How chronic immune activation keeps healing from sticking Why detox, hormones, immunity, and the nervous system must be addressed together And how to move forward with clarity instead of fear If you're tired of chasing symptoms and ready to understand why your body feels like it can't catch up—this episode is for you. Book a Free Clarity Call . We'd love to talk to you! Pharmacist Kari Coody and Integrative Health Practitioner Jenn Patriarca host weekly conversations meant to cut through the overwhelm of alternative healthcare options. Simple, effective, easy ways to pursue health and gain an understanding without a prescription pad. It's time to simplify the process of healing. Add us on Instagram: www.instagram.com/cornerstoneintgrativehealing Check out our site: www.cornerstoneintegrativehealing.com Watch us on YouTube: https://www.youtube.com/@cornerstoneintegrativehealth Add us on Facebook: www.facebook.com/cornerstoneintegrativehealing.com Send us an Email: hello@cornerstoneintegrativehealing.com The information shared in this episode is not meant to be medical advice. Please speak to your healthcare provider about making any changes to your healthcare plan.
We are in Week 3 of our 4-part series on Cancer, the #2 killer in America. Early diagnostics have helped reduce the death rate from Cancer. In this episode, you'll discover:—Why Dr. Prather says that diagnostics are even more important in the Structure-Function Health Care than in Disease Care.—The story of the oncologists who are surprised at how early Holistic Integration is able to detect certain types of Cancer that are usually not found until they are far more developed. —How Dr. Prather has over 600 hours of studying bloodwork, while the typical Medical Doctor has 15 hours of study in their education.—Why Liver Enzymes are so important in Cancer Diagnostics. And how Dr. Prather says keeping those levels where they should be actually helps patients to be able to complete their Chemotherapy and Radiation treatments. —The reason Dr. Prather does not recommend Coffee Enemas and instead offers his patients a safer and more gentle form of detoxification. —The astonishingly low percentage of patients who first come into Holistic Integration who have the right lab test values for their Liver and their Immune system.—Why tumor markers are important in Cancer diagnostics and in evaluating care. And why Dr. Prather tests for these more often than most Oncologists do. —The importance of Hair Analysis to determine Heavy Metals in the body that can lead to Cancer. And the worst toxin for Cancer, which was found in Agent Orange and passed onto the daughters of Vietnam Veterans who were exposed to it. —How 80% of the immune system is found in the gut, which is best tested through a stool kit. And the stories of Cancer patients who were helped because of the toxins, parasites, and infections detected in their stool kit. —The Micronutrients blood test that Dr. Prather recommends to all of his Cancer patients, which can help both in the prevention of Cancer and increasing someone's odds of surviving it.http://www.TheVoiceOfHealthRadio.com*Receive exclusive bonus content as a member of our Voice Of Health Patreon Community:https://www.patreon.com/cw/VoiceofHealthPodcast
In this encore episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support intestinal health, while highlighting intestinal mucosal anatomy.Topics:1. Introduction - Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃ 2. Vitamin D Synthesis and Metabolism - Skin and 7-dehydrocholesterol; dietary intake.- Transported through the bloodstream bound to vitamin D binding protein.- First hydroxylation in the liver to form 25-hydroxyvitamin D₃ (25(OH)D₃).- Testing.- Second hydroxylation in the kidney to form the active 1,25 dihydroxyvitamin D₃ (1,25(OH)₂D₃).- Local activation also occurs. 3. Intestinal Barrier Anatomy - The intestinal epithelium forms a selectively permeable monolayer that interfaces with the gut lumen.- Covered by a mucus layer.- Tight junction proteins and paracellular permeability.- The lamina propria and Gut-Associated Lymphoid Tissue (GALT). - Maintaining tolerance. 4. Vitamin D - 1,25-dihydroxyvitamin D₃, tight junction integrity, immune regulation, and more. 5. Vitamin D₂ and D₃ 6. Conclusion - Neither too high nor too low: optimal levels.- Multifactorial: Numerous factors regulate vitamin D levels.- Gastrointestinal health root cause approach.Thank you to our episode sponsor: 1. "Longevity" with Protein, Probiotics, Bovine Colostrum, Collagen, and More. Use code CHLOE for 25% off.*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Thanks for tuning in!Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Klaudia Balogh lives on the road as Chief Health Correspondent for Biohack Yourself Magazine. Which means... Airport food. Hotel gyms. Jet lag. Sleep disruption. Immune crashes. And the joy of explaining suspicious powders to security. So what does a real biohacker actually travel with? This is our midweek A Biohacker's Day episode. Enjoy! Follow Klaudia Balogh on Instagram. THIS SHOW IS BROUGHT TO YOU BY: BiOptimizers Sleep Breakthrough This festive season has been full of late nights. It's time to get sleep back on track, with BIOptimizers sleep and magnesium supplements which I take every night. Just go to BIOptimizers.com/tony and use code TONY15 for at least 15% off. Code works worldwide, and on all their products.
The whole Immune gang gathers with special guests Gretchen Diehl and Shruti Naik at The Incubator with an audience to celebrate the 100th episode. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Guests: Gretchen Diehl and Shruti Naik Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Diehl: Gut microbe-specific T cell development (Nature 2021) Diehl: Bacteria-induced IL-1 is gut protective (Gut Microbes 2022) Diehl: Microbiota, macrophages, IL10, and colitis (Gut Microbes 2022) Diehl: E. coli-activated circuit restrains gut inflammation (Cell Rep 2025) Naik: Commensals control skin inflammation (Science 2012) Naik: IL-17 and hypoxic stress during skin repair (Science 2022) Naik: Human psoriasis and spatial transcriptomics (Sci Immunol 2023) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
Dr. Neil Nathan is Board Certified in Family Medicine and Pain Management as well as a Founding Dip-low-mitt of the American Board of Integrative Holistic Medicine & International Society for Environmentally Acquired Illnesses.He spent over 50 years treating patients with chronic conditions related to environmental factors & now dedicates himself consulting & mentorship, writing several books for both health care professionals & patients.In this episode, you'll hear mold allergy vs illness, what symptoms mold toxicity can imitate, how to really test & what healing protocol can look like. If you liked this episode, you'll also like episode 234: FELON TO MILLION DOLLAR BUSINESS OWNER [REMASTERED] Guest: https://neilnathanmd.com/ Host: https://www.meredithforreal.com/ https://www.instagram.com/meredithforreal/ meredith@meredithforreal.comhttps://www.youtube.com/meredithforreal https://www.facebook.com/meredithforrealthecuriousintrovert Sponsors: https://www.jordanharbinger.com/starterpacks/ https://www.historicpensacola.org/about-us/ 01:35 — Conditions mold mimics04:00 — “It's not psychological”05:00 — Why medicine lags behind06:00 — The mold hoax narrative08:00 — How common mold really is11:00 — Mold and Alzheimer's risk12:00 — GI symptoms decoded13:00 — Fatigue that doesn't resolve18:00 — Mold toxicity vs allergy19:00 — Immune system tipping points20:00 — Stress, illness, and timing21:00 — Hive consciousness explained22:00 — Candida cravings aren't you23:00 — Zombie mold metaphor24:00 — EMFs enter the picture27:00 — Testing for mold toxicity38:00 — Low-carb for mold healing41:00 — Alcohol's real impact42:00 — Magnesium's critical role43:00 — Chronic deficiency mystery47:00 — Hormones after mold48:00 — Limbic system overload49:00 — Vagus nerve dysfunction50:00 — Mast cell activation51:00 — Rebooting nervous systems52:00 — Brain retraining programs58:00 — Detox hygiene at home59:00 — Why bleach backfires01:00:00 — Dust vs airflow01:01:00 — Water damage vigilance01:02:00 — Detox tools worth using01:04:00 — Balance over biohacking01:05:00 — What healing really requires01:06:00 — Living with intention01:07:00 — Final takeaways & resourcesRequest to join my private Facebook Group, MFR Curious Insiders https://www.facebook.com/share/g/1BAt3bpwJC/
If you've been told your failed IVF cycle was "just bad luck" or blamed on "egg quality," that explanation is incomplete. Bad luck is not a diagnosis. It simply means the underlying biological patterns have not yet been identified. IVF is a technical process that happens in a lab, but embryos still develop inside a living biological environment. If inflammation, energy production, immune signaling, or sperm DNA integrity are compromised, no protocol change alone can override that physiology. Repeating cycles without deeper interpretation often leads to the same outcomes, higher costs, and more emotional exhaustion. In this episode, I walk through the three biological patterns I consistently see behind embryo arrest, poor blast development, failed transfers, and unexplained IVF failure. More importantly, you'll learn how to use your past cycles as meaningful data so you can stop guessing and start making more strategic decisions before another round. In this episode, you'll learn: Why a technically "perfect" IVF cycle can still fail despite good labs and protocols How low cellular energy production impacts embryo development and early growth Why sperm DNA fragmentation often matters long before clinics flag it as abnormal How oxidative stress, inflammation, hormonal signaling, and metabolic strain influence embryo quality How to interpret repeated IVF outcomes instead of labeling them as unexplained or bad luck I'm Sarah Clark, founder of Fab Fertile and host of Get Pregnant Naturally. For over a decade, my team and I have reviewed hundreds of low AMH and failed IVF cases using functional testing alongside conventional fertility care. We specialize in helping couples identify the physiological patterns driving poor outcomes so decisions are grounded in interpretation, not guesswork. This episode is for you if: You've experienced embryo arrest, failed transfers, or repeated IVF cycles without clear answers You've been told everything looks "normal" but results keep falling short You want a smarter way to evaluate what your body is signaling before investing in another cycle
Weekly columnist, 25 year Chicago trial lawyer, and creator of "The Haake Take" Sabrina Haake explains why ICE goons are not immune from criminal prosecution under state laws. Also is there any doubt Trump has declared war on Minnesota? The Pentagon is preparing the infantry to be sent there & Stephen Miller has ordered the MN authorities to “stand down and deliver.” Trump has declared war with Europe, too, with Tariffs, and they are retaliating. Plus honoring Reverend Doctor Martin Luther King, Jr.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.