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Coming up, we explore how CAR-T cell therapy is revolutionising personalised cancer treatment. Plus, how NASA's DART mission tested Earth's asteroid defence, what we are learning about the benefits of breastfeeding for mother and baby health, and we delve into the physics behind squeaky shoes... Like this podcast? Please help us by supporting the Naked Scientists
Dr Hanny Al-Samkari from Massachusetts General Hospital in Boston discusses recent developments from the ASH 2025 Annual Meeting involving the use of Bruton tyrosine kinase inhibitors and BAFF-R antagonists in the treatment of immune thrombocytopenia.CME information and select publications here.
referencesCell Death & Disease 2026. 17, Article number: 71 Am J Physiol Cell Physiol. 2020 Dec 9;320(3):C415–C427Guerra, DJ.2026. Unpublished LecturesJagger/Richards. 1964. As Tears Go By. Marrianne Faithful https://open.spotify.com/track/2EYXCRp63iQdmeKHXN8Rrg?si=70ceced5d9304eb8Mozart , WA 1779. Sinfonia Concertante in E flat Major K.364https://music.youtube.com/watch?v=_0hTDZ0whpU&si=NNbjswoPokVPveuu
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/SAT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until February 22, 2027.Immune Innovation in Head and Neck Cancer: Insights on Checkpoint Inhibitors and Bispecifics Across Disease Settings In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Bicara Therapeutics Inc., Coherus BioSciences, Inc., Johnson & Johnson, and Merus.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/SAT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until February 22, 2027.Immune Innovation in Head and Neck Cancer: Insights on Checkpoint Inhibitors and Bispecifics Across Disease Settings In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Bicara Therapeutics Inc., Coherus BioSciences, Inc., Johnson & Johnson, and Merus.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/SAT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until February 22, 2027.Immune Innovation in Head and Neck Cancer: Insights on Checkpoint Inhibitors and Bispecifics Across Disease Settings In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Bicara Therapeutics Inc., Coherus BioSciences, Inc., Johnson & Johnson, and Merus.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/SAT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until February 22, 2027.Immune Innovation in Head and Neck Cancer: Insights on Checkpoint Inhibitors and Bispecifics Across Disease Settings In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Bicara Therapeutics Inc., Coherus BioSciences, Inc., Johnson & Johnson, and Merus.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/SAT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until February 22, 2027.Immune Innovation in Head and Neck Cancer: Insights on Checkpoint Inhibitors and Bispecifics Across Disease Settings In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Bicara Therapeutics Inc., Coherus BioSciences, Inc., Johnson & Johnson, and Merus.Disclosure information is available at the beginning of the video presentation.
Aging reshapes the immune system in two fundamental ways: it alters the proportions of different immune cell types circulating in the blood, and it induces molecular changes within each individual cell. For years, researchers have struggled to disentangle these two intertwined processes using standard “bulk” measurements, which average signals across millions of cells and obscure what is happening at the single-cell level. A new research paper, titled “Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV” published in Volume 18 of Aging-US by researchers at the Buck Institute for Research on Aging in California, the University of Southern California, and the University of Copenhagen, introduces an innovative solution. The team of Alan Tomusiak, Sierra Lore, Morten Scheibye-Knudsen, and corresponding author Eric Verdin, developed a novel tool called Tictock (T immune cell transcriptomic clock) that uses single-cell RNA sequencing to separately measure systemic and cell-intrinsic components of immune aging, and then applied it to understand how COVID-19 and HIV affect T cells. Full blog - https://aging-us.org/2026/03/tictock-a-single-cell-clock-measures-immune-aging-in-viral-infections/ Paper DOI - https://doi.org/10.18632/aging.206353 Corresponding author - Eric Verdin - EVerdin@buckinstitute.org Abstract video - https://www.youtube.com/watch?v=_r3AF7OrgKY Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206353 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, transcriptomic clock, aging biomarkers, systemic aging, intrinsic aging To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/SAT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until February 22, 2027.Immune Innovation in Head and Neck Cancer: Insights on Checkpoint Inhibitors and Bispecifics Across Disease Settings In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Bicara Therapeutics Inc., Coherus BioSciences, Inc., Johnson & Johnson, and Merus.Disclosure information is available at the beginning of the video presentation.
Gabrielle Rizzuto from Memorial Sloan Kettering Cancer Center discusses her work on the curious immunology of pregnancy and how a woman tolerates a genetically different baby but quickly rejects a mismatched organ donation. Host: Cindy Leifer Guest: Gabrielle Rizzuto Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Rizzuto lab at MSKCC Tolerance at the fetal-maternal interface (Nature, 2022) The paradox of fetal-maternal tolerance (J Exp Med, 2022) Spatially resolved timeline of fetal-maternal interface (Nature, 2023) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
Featuring an interview with Dr Hanny Al-Samkari, including the following topics: Mechanism of action and toxicity of the monoclonal antibody ianalumab (0:00) Primary results from VAYHIT2, a randomized, double-blind Phase III trial of ianalumab with eltrombopag for patients with primary immune thrombocytopenia (ITP) after failure of first-line corticosteroid treatment (7:32) Mechanism of action and toxicity of the Bruton tyrosine kinase inhibitor rilzabrutinib (11:52) Reduction in corticosteroid use with rilzabrutinib and sustained response in adults with persistent or chronic ITP in the long-term extension period of the Phase III LUNA3 study (18:46) CME information and select publications
ReferencesGuerra, DJ. 2026. Unpublished LecturesScience Translational Medicine 2019: 17 Jul. Vol. 11, Issue 501, eaav7816Lennon/McCartney. 1969. Let it Be Beatleshttps://open.spotify.com/track/7iN1s7xHE4ifF5povM6A48?si=77799fa1a6ca494e
Presenter: Mustafa Ozcam, PhD Emerging research is redefining the role of the gut microbiome in food allergy and immune tolerance. Here to share some of the most groundbreaking findings is Dr. Mustafa Ozcam. He discusses how gut microbes metabolize allergenic proteins, shape immune development, and serve as potential biomarkers to predict oral immunotherapy success in food allergy patients. Dr. Ozcam is an Assistant Professor of Microbiology and Immunology at the University of Maryland School of Medicine, and he spoke about this topic at the 2026 American Academy of Allergy, Asthma, and Immunology Annual Meeting.
ReferencesGuerra, DJ. 2026 Unpublished LecturesCell.2022 Jun 16;185(14):2542–2558.e18. https://omim.org/entry/607358Experimental & Molecular Medicine2025 57:1881–1892Hunter/Garcia, 1968. Dark Star Grateful Dead Live/Dead LP https://open.spotify.com/track/07CwWCJetytT1cSnQOgRMU?si=de8e173488834efb
Send a textDr. Allison Reiss, MD is an internal medicine physician, molecular biologist, and educator whose career sits at the critical intersection of inflammation, cardiometabolic disorders, and neurodegeneration.Dr. Reiss serves as Associate Professor of Medicine and Head of the Inflammation Laboratory at the NYU Grossman Long Island School of Medicine ( https://medli.nyu.edu/faculty/allison-b-reiss ). She is also a Member of the Medical, Scientific & Memory Screening Advisory Board of the Alzheimer's Foundation of America.For more than 25 years, Dr. Reiss' research has explored how immune and metabolic dysfunction contribute to neuronal loss in Alzheimer's disease and accelerated atherosclerosis in conditions such as lupus, rheumatoid arthritis, and diabetes — helping illuminate the biological links between brain health, vascular disease, and aging.Clinically trained and board-certified in internal medicine, Dr. Reiss brings a rare translational perspective, connecting bedside observations with molecular mechanisms. Beyond the lab, she is a dedicated mentor and educator, directing translational research training for medical students and actively inspiring the next generation of clinician-scientists.Dr. Reiss' work has been recognized by organizations including the American Heart Association and the Alzheimer's Foundation of America, and she serves in editorial leadership roles across several journals focused on cardiovascular disease, aging, and neurodegeneration.On this episode, we explore the evolving science of neuroinflammation, the metabolic roots of Alzheimer's disease, and how understanding immune-brain-vascular crosstalk may unlock entirely new therapeutic strategies for aging populations.#AlzheimersDisease #Neuroinflammation #BrainHealth#DementiaPrevention #MetabolicHealth #VascularHealth#LongevityScience #Neurodegeneration #MedicalResearch #PhysicianScientistSupport the show
Episode Description Making babies is expensive. For pretty much every species on the planet, reproduction is supposed to be the ultimate metabolic investment—a massive energy drain that can make organisms vulnerable to stress, predators, and environmental change. Except there's a small shark walking around the Great Barrier Reef that apparently didn't get the memo. In this episode of our Ocean Lovin' series, we explore groundbreaking research from James Cook University that's forcing scientists to completely rethink what they know about the costs of reproduction. Epaulette sharks—those amazing little "walking sharks" that can literally stroll across reef flats on their fins—can produce complex egg cases with developing embryos inside without any measurable increase in energy use. Zero. Zilch. Nada. It's like building a house without buying any extra lumber. Join hosts Andrew Kornblatt and Dr. Frances Farabaugh, along with returning guest co-host Dr. Skylar Bayer, as we dive into this surprising discovery with Professor Jodie Rummer from James Cook University. We'll explore how her team measured something no one had measured before—the metabolic cost of egg-laying in sharks—and what they found challenges fundamental assumptions about reproduction in the ocean. We'll learn about the "pay as you go" hypothesis, discover why a tiny organ might be working overtime without changing the whole shark's energy budget, and explore what this means for sharks facing climate change. From the controlled environment of the lab to wild populations scattered across the Great Barrier Reef, this research reveals that evolution has equipped some species with surprising tools for survival that we're only beginning to understand. Content Advisory: This Ocean Lovin' episode deals with mature subjects related to marine reproduction. Please listen to the full episode before sharing with younger audiences. Featured Guest Professor Jodie Rummer Professor of Marine Biology, James Cook University, Australia Conservation physiologist specializing in sharks and coral reef fishes Leads shark physiology research team at JCU's Marine and Aquaculture Research Facility Maintains a breeding colony of epaulette sharks for multi-generational research Expert in how marine organisms cope with climate change stressors (temperature, ocean acidification, low oxygen) Key Topics Covered The Discovery First direct measurement of metabolic costs of egg-laying in sharks Completely flat metabolic rate across reproductive cycle—no energy spike 37 trials, nearly 200 eggs, almost 100 reproductive cycles The Science How scientists measure metabolic rate through oxygen uptake The "pay as you go" hypothesis: income breeding vs. stored energy The nidamental gland paradox: tiny organ, massive output Blood chemistry and hormone stability during reproduction Epaulette Shark Biology One of nine "walking shark" species with modified pectoral fins Can survive zero oxygen conditions for several hours Endemic to Great Barrier Reef, living in extreme reef flat environments Produce two eggs every ~19 days during breeding season Four-month embryonic development period Climate Change Implications Challenging the assumption that "reproduction will be the first thing to go" under stress Potential resilience in warming oceans—but limits unknown Effects of elevated temperatures on embryo development and hatchling size Importance of protecting critical habitats where adaptations can function Future Research Directions Testing upper limits of reproductive efficiency under warming Local adaptation across Great Barrier Reef populations Immune function in mothers and hatchlings under stress Applications to other shark species and conservation strategies Featured Research Primary Study: Wheeler, C.R., Awruch, C.A., Mandelman, J.W., & Rummer, J.L. (2025). "Assessing the metabolic and physiological costs of oviparity in the epaulette shark (Hemiscyllium ocellatum)." Biology Open, 14(11). DOI: 10.1242/bio.062076 Lead Author: Dr. Carolyn Wheeler (recent JCU PhD graduate) Resources & Links Research Institution: James Cook University Marine and Aquaculture Research Facility, Townsville, Australia JCU Marine Biology Conservation Organizations: Great Barrier Reef Marine Park Authority IUCN Shark Specialist Group Press Coverage: JCU News Release ScienceDaily Article Episode Credits Hosts: Andrew Kornblatt - Climate and Ocean Communications Specialist, Producer Dr. Frances Farabaugh - Shark Ecologist, Aquanaut Guest Co-Host: Dr. Skylar Bayer - Marine Ecologist (Shellfish Population Dynamics, Fertilization Ecology, Science Communication) Featured Guest: Professor Jodie Rummer - James Cook University
ReferencesImmun Ageing. 2020; 17: 2.Trends in Immunology. 2017. REVIEW| VOLUME 38,ISSUE 4, P287-297, APRIL 01, Int J Mol Sci. 2025 Apr 27;26(9):4147Experimental & Molecular Medicine 2019. volume 51, Article number: 80 Beethoven, LV 1811. Piano Concert V in E Flat Major OP 73.https://music.youtube.com/watch?v=q-hn8WH_-3U&si=TNpna_2DZLIoX2nM
ReferencesSCIENTIFIC REPORTS 2016 | 6:34594 | DOI:10.1038/srep34594 Seminars in Immunology 2025. V. 78,Jun, 101954Front Immunol. 2025 Jan 8:15:1515715Telemann, GP. 1735. Sinfonia Spirituosa TWV 40&50https://open.spotify.com/album/2nJX3LIjdAbNIGR3qbQaBI?si=VF-7aHcBS_qOkEsl34LdKQ
ReferencesAntimicrob Agents Chemother. 2017 Dec 21;62(1):e01614-17Br J Cancer. 2002 Mar 18;86(6):963–970Science Translational Medicine 2019: vol. 11, Issue 501, 17 Jul Int J Mol Sci. 2025 Apr 27;26(9):4147 Fogerty, J 1969. Fortunate Son. CCRhttps://open.spotify.com/track/4BP3uh0hFLFRb5cjsgLqDh?si=5b6bd7dea0774f9dHunter/Garcia. 1973 It Must Have Been the Roses. Grateful Dead [Reckoning] lphttps://music.youtube.com/watch?v=tvXQ7r-n-Go&si=J6mTP9rquTHkNo-D
The immune-conflict between dam and fetus could help explain sex differences in neurodevelopmental conditions.
On this episode, Jared takes a deep dive into Biocidin, a practitioner-trusted botanical formula long used in functional and integrative wellness settings. Learn what makes this multi-herb blend unique and why it's often included in protocols designed to support oral health, gut health, immune resilience, and overall microbial balance. Jared explains biofilms in simple terms, why they matter for long-term wellness, and how botanical formulas like Biocidin are used to help maintain a balanced microbiome throughout the body. From the mouth and throat to the digestive tract and beyond, this episode explores real-world applications, research insights, and practical considerations for using multi-botanical support as part of a comprehensive wellness strategy. Part one focuses on education and understanding, while part two will cover how practitioners typically structure supportive protocols.Products:Biocidin and Dentalcidin ProductsVitality Radio POW! Product of the Week: Utzy Naturals Magnositol and Utzy Naturals Coll-U-Gen Get 35% off one bag or 45% off two or more bags (mix and match OK!) No Code Needed! (while supplies last)Additional Information:#555: From Gut to Gums: Mastering Microbial Balance Using Biocidin with Dr. Shawn Manske#617: Microbiome Balance from Mouth to Gut: Protocols for Clearing and Rebuilding with Biocidin – Part 2Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
Shaun broadcasts LIVE from Meridian Banquets in Rolling Meadows, IL ahead of President Trump's State of the Union address! PLUS, Shaun talks to Dr. Michael Huber, the creator of Virogo, about the natural health benefits of Virogo and how it fights back against everything (even Democrat air)! Use promo code IMMUNE to save 30%! And The Heritage Foundation's Simon Hankinson talks to Shaun about our imported Afghan problem and how President Trump is fighting illegal immigration by....enforcing the law!! See omnystudio.com/listener for privacy information.
ReferencesFront Immunol. 2015 Sep 28;6:493Guerra, DJ. Unpublished LecturesInt J Mol Sci. 2025 Apr 27;26(9):4147Biomolecules2019, 9(10), 513Vivaldi, A. 1715. The Great Venetian Masshttps://music.youtube.com/playlist?list=OLAK5uy_nz3Iy2f-mkA2jbas2npilpkSh3Db5l-wY&si=DesZSQv0ZBZcvrw-
Dr. Ronald Lane, Founder of HOPE-Neuron Therapeutx, is developing an approach to treating ALS by rebalancing the body's immune system, which becomes dysfunctional in neurodegenerative diseases. The mechanism involves treating a patient's blood outside the body to activate the immune system and then infusing it back into the patient. The theory is that traditional drugs often fail because they target static genetic mutations and symptoms, while the source of the disease lies in the ongoing immune imbalance. Ronald explains, "Well, in a broad sense, the goal of HOPE Neuron is based on the fact that our challenge here is to bring hope. And we use a neuronal basis to do that. We're not about drugs. There are no chemicals involved. We don't go that direction. But basically, it cuts across. We deal with memory, we deal with dementia and Alzheimer's, but our target initially is ALS." "As I mentioned a moment ago, we're not doing drugs, we're not using chemicals. So what are you doing? Well, we're using the cell's immune system, and the problem with disease is that the immune system gets out of balance. When it's out of balance, you become ill. It can be in many different diseases. And there are certain indicators, and we know what to look for and what compounds the body generates." #HOPENeuron #ALS #Neurology #ImmuneTherapy #MedicalInnovation #ALSResearch #Biotechnology #NeurodegenerativeDisease #MedicalBreakthrough #ClinicalTrials #Healthcare #Innovation #Neurodegeneration #Neuroplasticity #MedicalDevices #Immunotherapy #NeuroscienceInnovation #FutureOfMedicine #NonPharmaTherapies hopeneuron.com Listen to the podcast here
Dr. Ronald Lane, Founder of HOPE-Neuron Therapeutx, is developing an approach to treating ALS by rebalancing the body's immune system, which becomes dysfunctional in neurodegenerative diseases. The mechanism involves treating a patient's blood outside the body to activate the immune system and then infusing it back into the patient. The theory is that traditional drugs often fail because they target static genetic mutations and symptoms, while the source of the disease lies in the ongoing immune imbalance. Ronald explains, "Well, in a broad sense, the goal of HOPE Neuron is based on the fact that our challenge here is to bring hope. And we use a neuronal basis to do that. We're not about drugs. There are no chemicals involved. We don't go that direction. But basically, it cuts across. We deal with memory, we deal with dementia and Alzheimer's, but our target initially is ALS." "As I mentioned a moment ago, we're not doing drugs, we're not using chemicals. So what are you doing? Well, we're using the cell's immune system, and the problem with disease is that the immune system gets out of balance. When it's out of balance, you become ill. It can be in many different diseases. And there are certain indicators, and we know what to look for and what compounds the body generates." #HOPENeuron #ALS #Neurology #ImmuneTherapy #MedicalInnovation #ALSResearch #Biotechnology #NeurodegenerativeDisease #MedicalBreakthrough #ClinicalTrials #Healthcare #Innovation #Neurodegeneration #Neuroplasticity #MedicalDevices #Immunotherapy #NeuroscienceInnovation #FutureOfMedicine #NonPharmaTherapies hopeneuron.com Download the transcript here
David Kavanagh, MBChB, PhD, FRCP - A Clinically Considered Real-World Case Series: Practice Essentials From Biopsy To Diagnosis in Immune-Mediated Glomerular Diseases
David Kavanagh, MBChB, PhD, FRCP - A Clinically Considered Real-World Case Series: Practice Essentials From Biopsy To Diagnosis in Immune-Mediated Glomerular Diseases
Immune discusses how tattoo ink accumulates in lymph nodes, promotes inflammation and influences response to two different vaccines. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server IL-9, CAR T cells and anti-tumor CD8 cells Tattoo ink, inflammation and vaccines Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
ReferencesGuerra, DJ 2026. Unpublished LecturesThe Journal of Biological Chemistry 2018 293, 19001-19011 Int J Mol Sci. 2025 Apr 27;26(9):4147Cell Death & Disease 2019. v 10, Article number: 315 Hunter/Garcia/Kreutzmann. 1975 Franklin's Tower. Grateful Dead.https://open.spotify.com/track/3PgIhd4XmwtmV2XGU5qhzZ?si=7714f01313ca477bTravis, M. 1946. !6 Tons. Tennessee Ernie Fordhttps://open.spotify.com/track/3P6OwCX7Ofiaaqtvujb6i5?si=4b8704749b6e4390
What if the diet you've been following diligently — eating all the right things, tracking your macros, staying committed — is actually wrong for your specific biology? In this solo episode I share the anonymised case of a real client who gained eight kilograms following a ketogenic diet perfectly. Not because she was doing it wrong. Because her genetics made her one of the worst possible candidates for high saturated fat eating — and nobody had ever looked at her DNA. We go deep on the three specific genetic variants that predicted her poor response to keto, what her full microbiome mapping revealed that standard testing would have completely missed, and how her hormonal picture and chronic stress were silently driving the whole metabolic picture. This episode is for anyone who has tried hard, followed the advice, and still isn't getting results. It's time to stop blaming yourself and start looking at your biology. We cover why Instagram diet advice is genuinely dangerous for people with different genetics, what comprehensive functional testing actually looks like — DNA panels, microbiome mapping, DUTCH hormone testing, detailed bloodwork — and the universal dietary principles that apply to almost everyone regardless of their genetic profile. Your body is not broken. It just needs the right instructions. Find Lisa at lisatamati.com, shop supplements at shop.lisatamati.com, and try Rejuvenate Pro — our flagship Immune and gut health/longevity supplement — at https://shop.lisatamati.com/pages/rejuvenate Discover your immune age at myimmuneage.life Subscribe to my weekly longevity newsletter at lisatamati.com/lisa
You're taking 600 IU of vitamin D.Your labs say “normal.”But you could still be deficient. In this episode, Ben reveals why the official vitamin D recommendations were based on preventing rickets, not optimizing immunity, metabolism, muscle, or brain health. Independent researchers reanalyzed the original RDA data and found the required intake for adequacy was dramatically higher — yet the guidelines barely changed. Vitamin D is not just a vitamin. It functions like a steroid hormone and impacts: Immune regulation Inflammation control Insulin sensitivity Muscle protein synthesis Brain function Low vitamin D is strongly associated with insulin resistance, and since 93% of Americans are insulin resistant, this could be a massive blind spot. Ben also explains: Why “normal” lab ranges may still mean deficiency Why optimal levels should be above 60 ng/mL How obesity lowers circulating vitamin D Why magnesium and vitamin K2 are required for proper activation Why toxicity fears are overblown compared to widespread insufficiency You'll also learn the simple 3-step plan to optimize vitamin D safely: Smart midday sun exposure Intelligent supplementation with D3 + K2 + magnesium Regular testing and cofactor support If you're over 45, insulin resistant, or struggling with stubborn inflammation, this episode could be a game changer. You don't have a weak immune system.You may just have an under-supported one. Get 20% off with code FREEDOM at :https://bit.ly/46irN6O FREE GUIDE: The World's Easiest Breakfast Diet To Melt Fat HERE - https://bit.ly/4ryX1yC
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss reversal of last week's no review decision on a flu mRNA vaccine by Vinjay Prasad, appointment of Jay Bhattacharya as CDC director, no experience required, and already detectable reduction in hepatitis B virus vaccination rates, then Dr. Griffin then deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, how to access and pay for Paxlovid, the consequences of measles infection on immune amnesia (shout out to Immune 26), long COVID treatment center, where to go for answers to your long COVID questions, long COVID effect on fertility and type 2 diabetes and contacting your federal government representative to stop the assault on science and biomedical research. Click arrow to play Download TWiV 1298 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Whiplash! F.D.A. Reverses Decision and Agrees to Review Moderna's Flu Vaccine (NY Times, Wall Street Journal, Access New wire) N.I.H. Director Will Temporarily Run C.D.C. in Leadership Shake-Up (NY Times) Reduction in infant Hepatitis B Immunizations (Oregon State Health Department) Why Adenovirus vectored vaccine failed: Adenoviral Inciting Antigen and Somatic Hypermutation in VITT (NEJM) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard(South Carolina Department of Public Health) Measles Outbreak Hits Florida College (NY Times) Utah's measles outbreak reaches 300 cases (CIDRAP) Measles Is Actively Spreading in SLCo (Salt Lake County Health Department) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles(CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Measles 2025 (NEJM) Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens (Science; Immune 26) Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles (Science) Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands (Nature Communications) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Weekly surveillance report: cliff notes (CDC FluView) OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) US respiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) The risk of cardiac disease events after respiratory syncytial virus disease: a systematic literature review and meta-analysis (European Respiratory Review) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) COVID-19 Antiviral Prescription Receipt Among Outpatients Aged ≥65 Years (CDC: MMWR) Where to get pemgarda (Pemgarda) EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulation guidelines (hematology.org) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Assessing the impact of SARS-CoV-2 infection and vaccination on fertility and assisted reproductive techniques outcomes: an umbrella review (Vaccine) Long-Term Risk of Incident Type 2 Diabetes Following SARS-CoV-2 Infection: A Population-Based Study in British Columbia, Canada (Diabetes Metabolism Research and Review) Reaching out to US house representative Letters read on TWiV 1298 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.
"Because the premise of immune checkpoint blockade centers around elevating the immune function, we should always take a great deal of caution around those patients who have high immune risks. Those include patients with autoimmune disorders. That's one of our biggest questions that we ask, usually every consult that we're seeing with solid tumor. 'Do you have any history of autoimmune disorders? Tell me a little bit more about it. Is it being treated? What are your symptoms like?' And then also patients who have undergone organ transplants. Now, interestingly, this does include stem cell transplants," Kelsey Finch, PharmD, BCOP, oncology pharmacist practitioner at Columbus Regional Health in Indiana, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about checkpoint inhibitors. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by February 20, 2027. Kelsey Finch has disclosed a speakers bureau relationship with AstraZeneca. This financial relationship has been mitigated. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge related to checkpoint inhibitors in the treatment of cancer. Episode Notes Complete this evaluation for free NCPD. ONS Podcast™ episodes: Pharmacology 101 series Episode 273: Updates in Chemotherapy and Immunotherapy Episode 174: Administer Pembrolizumab Immunotherapy With Confidence Episode 139: How CAR and Other T Cells Are Revolutionizing Cancer Treatment ONS Voice articles: Here's Why Oncology Nurses Are Pivotal in Managing Immune-Related Adverse Events Make Subcutaneous Administration More Comfortable for Your Patients Nursing Considerations for ICI-Related Myocarditis Oncology Nurses Navigate the Changing Landscape of Immuno-Oncology Postdischarge ICI Patient Education Eliminates Hospital Readmissions Shorter Administration Times Still Require High-Acuity Care ONS Voice oncology drug reference sheets: Dostarlimab-Gxly Nivolumab and Hyaluronidase-Nvhy Nivolumab and Relatlimab-Rmbw Pembrolizumab and Berahyaluronidase Alfa-Pmph Retifanlimab-Dlwr Toripalimab-Tpzi ONS books: Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice (second edition) Guide to Cancer Immunotherapy (second edition) ONS course: ONS/ONCC® Chemotherapy Immunotherapy Certificate™ Clinical Journal of Oncology Nursing articles: Immune Checkpoint Inhibitor–Related Myocarditis: Recognition, Surveillance, and Management Immune Checkpoint Inhibitor Therapy: Key Principles When Educating Patients Triple M Syndrome: Implications for Hematology-Oncology Advanced Practice Providers ONS Huddle Cards: Checkpoint Inhibitors Immunotherapy ONS Learning Libraries: Genomics and Precision Oncology Learning Library Immuno-Oncology Learning Library Drugs@FDA package inserts National Comprehensive Cancer Network homepage OncoLink: All About Immunotherapy To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "Before immune checkpoint blockade, the two-year overall survival rate in metastatic melanoma was hovering around 10%. After these agents came to market, depending on the trial and the agents used, that number actually increased to about 50%–65%. So, five times the amount of patients were actually living at the two-year mark. Not surprisingly, studies then exploded across several tumor types, leading to approvals in all sorts of cancers, mostly in the solid tumor. But there are a couple hematologic as well. Lung cancer, kidney cancer, head and neck, Hodgkin lymphoma, hepatocellular, the list goes on. So, it's really just transforming the stage IV setting across all tumors, specifically from uniformly fatal prognosis to one where durable responses and long-term survival is also possible." TS 3:03 "There are four different mechanisms officially being used in therapies that are approved by the U.S. Food and Drug Administration (FDA). Those are cytotoxic T-lymphocyte–associated protein 4, programmed cell death protein 1, and programmed cell death ligand 1, which I'm counting as two different mechanisms, even though they somewhat work together. And lymphocyte-activation gene 3 is the fourth one that's in there. So, all these mechanisms impact the T cell in our immune system. The T cell is traditionally responsible for protecting our body from harmful things like bacteria, viruses, and cancer. When the tumor binds to cytotoxic T-lymphocyte–associated protein 4 receptors, that happens on the T cell itself. And that inhibits the activation of the T cells, essentially allowing that tumor to then live. So when developing medications that block this receptor, they noted an added benefit that it actually increased the T-cell proliferation as well as keeping that T cell active. So not only are we not blocking the T cells, we're making them more productive." TS 5:38 "If you have a chance of any sort of tissue rejection, specifically with allogeneic stem cell transplants or where we see that focusing on it, there's a little bit of controversy, mixed bag on opinions as far as autologous stem cell transplants. But it's best to at least exercise a little bit of caution. If they have a chance of organ rejection, is that worth the risk of the therapy that we're looking to give? And then, patients with HIV, any sort of immunologic concerns at baseline that we could potentially worsen." TS 14:37 "As a rule of thumb, with immune checkpoint blockade, regardless of what mechanism you're looking at, if something in your body can get inflamed, that can wind up as an adverse event. So, whenever I talk to my patients, the key word is anything ending in '-itis.' ... The most common adverse events that we end up seeing are dermatitis and hypothyroidism. Immune checkpoint blockade can cause both hyper- and hypothyroidism. Very often, we actually start in the hyper- and then end up, for lack of better words, burning out the thyroid, ultimately leading to a sustained hypothyroidism." TS 18:34 "The half-life of immune checkpoint inhibitors is usually around 30 days, meaning that once these agents are given, the drug will be in the patient's system for up to five months. Specifically, it will probably build month to month, so often we don't even see a lot of our adverse events until month three or four. Usually, when we're that far into treatment, we're not looking for new adverse events in things like chemotherapy. But these drugs do build over time." TS 24:28 "As far as safe handling is concerned, these agents are not chemotherapy. That makes drug compounding and administration pretty straightforward. When looking at the follow-up care, the most important thing, in my opinion, is to engage in meaningful dialogue with your patients. A lot of the side effects can be nonspecific. So, really listening to the patient and evaluating changes in their lifestyle, I think it'll get you far. We usually hark in on the new, worsening, or persistent whenever we're talking to patients because they'll be looking for things as well. So, just having a dialogue of how their life has changed can certainly help." TS 26:17
Send a textIn this episode of The Autoimmune RESET Podcast, I'm sharing some of the key ideas from a full-day practitioner training I recently delivered on arthritis — and why the way we think about joint pain needs to change.For decades, arthritis — particularly osteoarthritis — has been framed as a simple story of wear and tear. Something mechanical. Something inevitable. Something that happens as we age.But that explanation is incomplete.Joint health is not just about cartilage. It is about the immune system, the gut, the nervous system, metabolism, and the body's ability to resolve inflammation. Arthritis is often a systemic condition that happens to be expressed through the joints.In this episode, we explore the deeper physiology behind inflammatory joint symptoms, including:• The gut–joint connection and intestinal permeability • Microbial triggers linked to autoimmune arthritis • The role of short-chain fatty acids and immune tolerance • Omega-3 fatty acids and the resolution of inflammation • Why digestion and absorption are often overlooked foundations • Nervous system regulation and pain signalling • The importance of sequencing interventions rather than doing everything at onceI also share reflections from my own experience of living with significant joint pain for many years, and what I've learned from working with clients who move from daily inflammation and limitation to meaningful recovery.One of the most important messages in this episode is that healing rarely happens through quick fixes. It happens through a layered, strategic approach — stabilising foundations first, then building resilience over time.If you are living with joint pain, stiffness, autoimmune arthritis, or inflammatory flares, this conversation will help you understand why your symptoms may be happening and what you can begin to do about them.Because arthritis is not always inevitable. And it is very rarely just about ageing.arthritis, autoimmune disease, gut health, inflammation, omega-3, digestion, nervous system, joint pain, immune regulation, functional medicine
Mark sits down with Joel Greene to unpack the sugar diet—why it can work short-term (hello, glycolysis), what it may shift long-term (gut taxa + immune cell metabolism), and why the body isn't a “static machine.” They also hit insulin sensitivity, keto/carnivore blind spots, the “calorie is a calorie” debate, and why rhythms/pulses beat doing the same thing daily.Special perks for our listeners below!
Is the brain really the source of mind — or is consciousness something more deeply biological?In this conversation, Anna Ciaunica challenges neurocentrism and explores the idea that cognition may not begin with neurons at all. We examine neuroimmune coupling, pregnancy as a nested model of subjectivity, basal intelligence before brains, and the fragile embodied self revealed in depersonalization experiences.We also explore biological idealism, multiscale intelligence, and whether artificial systems can ever replicate the ontological structure of living organisms.Topics include:• Neurocentrism and its limits• Immune systems as fact-checkers for survival• Basal cognition before neurons• Pregnancy and nested subjectivity• The fragile embodied self• Depersonalization & active inference• Touch and self-other boundaries• Biological idealism explained• Ontological differences between AI and life• Multiscale intelligence and self-organizationThis episode moves from cells to selves to artificial systems — and asks whether experience might be more fundamental than we assume.TIMESTAMPS:(0:00) – Introduction & The Challenge to Brain-Centrism(4:33) – Philosophy's Role in Questioning Scientific Assumptions(8:47) – Neuroimmune Coupling & The Origins of Thought(14:56) – Pregnancy, Nested Systems & Cellular Perception(17:18) – Embodiment in Early Development(23:47) – Phenomenal vs Grounded Experience(29:46) – Fetal Sensory Processing & Early Cognition(36:20) – Layered Analogies for Cognition(40:09) – Basal Intelligence Before Neurons(46:24) – Soma-Sema Theory & Death Anxiety(51:23) – Birth, Death & Ontological Boundaries(55:25) – Depersonalization & The Fragile Self(1:03:39) – Cracks in Transparency & Self-Perception(1:10:50) – Touch, Interaction & Self-Other Boundaries(1:16:45) – The “No Body” Problem(1:21:08) – Brain ≠ Mind: The Neuroimmune Challenge(1:29:09) – Biological Idealism Explained(1:37:59) – AI vs Biological Ontology(1:46:43) – Hidden Assumptions in AI Discourse(2:00:05) – Final ThoughtsEPISODE LINKS:- Anna's Website: https://annaciaunica.fr/- Anna's X: https://x.com/AnnaCiaunica- Anna's Bluesky: https://bsky.app/profile/annaciaunica.bsky.social- Anna's Publications: https://scholar.google.com/citations?user=ZUMz7EAAAAAJ&hl=en- From Cells to Selves: https://aeon.co/essays/why-you-need-your-whole-body-from-head-to-toes-to-think- When The Self Slips: https://aeon.co/essays/what-can-depersonalisation-disorder-say-about-the-selfCONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@MindBodySolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.
Send a textIn this episode of Never Been Sicker, Michael Rubino talks with Dr. Alex, a chiropractor who approaches chronic symptoms through immune response, nervous system function, nutrition, and environmental triggers. They unpack common root causes behind headaches, brain fog, fatigue, hormone issues, and histamine imbalance, plus why so many people are told “your labs look normal” while still feeling awful.They also explore how mold exposure can affect different people in the same home in completely different ways, why fixing the environment is often step one, and how detox should start with foundational pathways like digestion, hydration, sweating, and lymphatic support. Dr. Alex shares how he uses testing to personalize protocols and why there should always be a plan, not just a prescription.If you are dealing with chronic symptoms, suspected mold exposure, histamine issues, or fertility concerns, this conversation will help you understand what to look at next.00:00 Intro: Michael welcomes Dr. Alex00:30 Dr. Alex background: pain, spine, neuro issues, immune response01:30 Why people seek help and why symptom chasing fails02:10 Headaches: structural causes vs histamine and hormones03:00 Histamine explained in simple terms and why it matters04:20 Why Dr. Alex moved into a functional approach05:30 Chronic inflammation from “healthy” foods and hidden triggers07:10 “Test, do not guess” for the body and the home09:00 Never Been Sicker: rising prescriptions and chronic illness10:10 Why chiropractors do not prescribe and the herbal foundation11:20 “Where is the plan to get people off meds?”13:00 No quick fixes: the effort required to actually heal15:20 Nutrition confusion and why bio individuality wins16:30 Same house, different symptoms: immune response differences19:20 Environmental toxins are involved for most patients21:00 Michael explains hidden mold drivers and building science basics23:00 Why you cannot heal fully while still living in exposure24:05 Infertility, hormones, and mold disruption26:00 Using the Dust Test and pairing it with body testing28:00 How Dr. Alex realized mold was part of stubborn cases31:15 Biggest lie: “You'll be on meds for life” and “labs are normal”36:00 Care matters: rushed appointments vs real root cause time38:30 Detox foundations: lymph, hydration, movement, sweating40:45 Why random binders can backfire if pathways are blocked43:00 Controversies: normalizing toxins, fluoride, root canals45:00 Where to find Dr. Alex and his practice-----------------------------------------------------------------------------------------------
America Out Loud PULSE with Dr. Myriah Hinchey – Dr. Crista clarifies the critical distinction between common environmental molds and the dangerous conditions associated with water-damaged buildings, where mycotoxin-producing species can thrive and create a chronic inflammatory burden on the body. Together, they discuss how exposure can occur not only through inhalation but also through...
Anna Beaudin from University of Utah talks about the key thread of her career, development, and how that influences her research on the events happening during critical prenatal windows shapes everything from the developing immune system to hearing loss. Host: Cindy Leifer Guest: Anna Beaudin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Beaudin lab at University of Utah PhD work on metabolism and development Postdoc work on hematopoietic stem cells Maternal inflammation and hematopoietic stem cell development Prenatal inflammation effect on postnatal immunity Early life inflammation and hearing loss Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
America Out Loud PULSE with Dr. Myriah Hinchey – Dr. Crista clarifies the critical distinction between common environmental molds and the dangerous conditions associated with water-damaged buildings, where mycotoxin-producing species can thrive and create a chronic inflammatory burden on the body. Together, they discuss how exposure can occur not only through inhalation but also through...
Sony has accomplished a truly rare feat in this contentious era by providing players with a widely-lauded hour-plus State of Play presentation. At the top of the heap of announcements for many are a duo of God of War-related unveilings -- the long-rumored 2.5D Metroidvania game and an early-in-development ground-up remake of the original PS2 and PS3 trilogy -- with the former project stealth released at the time of its reveal. That's right: You can buy it right now! 29 other games were showcased, revealed, and otherwise shown off during the proceedings as well, like a new Castlevania called Belmont's Curse, a sequel to Kena: Bridge of Spirits called Scars of Kosmora, a AAA John Wick project, stealth title Yakoh: Shinobi Ops, the second volume of Konami's Metal Gear Collection, and much, much more. Plus, fresh looks at Saros, Resident Evil: Requiem, Marathon, Mina the Hollower, Beast of Reincarnation, Marvel Tokon, Control Resonant, Pragmata, 4LOOP, and so on. Other news rounds things out this week -- like steep layoffs at Highguard studio Wildlight and casting details for 2027' Helldivers film -- before we move onto listener inquiries. Who are some of our favorite black characters in gaming history? Why exactly doesn't Colin care about sports games anymore? Should Sony more heavily pursue Astro Bot spinoffs? Did the all-Spanish Super Bowl Halftime Show send any of us into an unspeakable rage? Get 50% off your first box and free breakfast for a year at https://www.factormeals.com/sacred50off and use code sacred50off Sign up for your $1 per month trial period at https://www.shopify.com/sacred Please keep in mind that our timestamps are approximate, and will often be slightly off due to dynamic ad placement. 0:00:00 - Intro0:28:09 - Love to Sean0:35:17 - Superbowl thoughts0:52:00 - GTA regret after murder0:57:09 - State of Play1:05:20 - Kena: Scars of Scars of Kosmora1:10:20 - Ghost of Yotei: Legends1:16:04 - Death Stranding 2 PC1:18:46 - 4:Loop1:26:26 - Capcom updates1:27:08 - Legacy of Kain Defiance Remastered1:29:41 - Brigandine1:31:45 - Dead or Alive1:33:16 - Control Resonant1:35:11 - Crimson Moon1:37:28 - Beast of Reincarnation1:39:58 - Rayman 30th Anniversary Edition1:44:21 - Mina the Hollower1:45:39 - Yakoh Shinobi Ops1:48:27 - Project WIndless1:53:36 - Star Wars Galactic Racer1:58:15 - Metal Gear Solid Collection Vol 22:02:42 - Konami segment2:14:47 - John Wick2:18:33 - Marathon2:21:44 - Saros2:22:18 - Tokon2:24:18 - God of War2:37:36 - Highguard layoffs3:17:22 - Horizon 3 could be 3-5 years out3:29:43 - Kojima revealed he almost worked with Respawn3:38:21 - Build A Rocket Boy still claims they were sabotaged3:53:22 - Helldivers movie update3:58:15 - What We're Playing (Lovish, Astalon: Tears of the Earth, Turok 2: Seeds of Evil, Resident Evil 5, Dragon Quest VII: Reimagined)4:22:16 - PlayStations online negativity4:29:25 - Black History Month in gaming4:34:24 - Returning to Madden?4:35:49 - Women in the industry4:41:20 - Should Sony focus on uncslop?4:43:40 - Where are the Astrobot spinoffs? Learn more about your ad choices. Visit podcastchoices.com/adchoices
This is episode 76 of the Love, Hope, Lyme podcast. To get your free pdf of "Love, Hope, Lyme: What Family Members, Partners, and Friends Who Love a Chronic Lyme Survivor Need to Know," reach out to Fred Diamond on social media. [NOTE: This podcast does not replace medical treatment. If you struggle with Lyme care, please see a Lyme Literate Medical Doctor.] In this episode of the Love, Hope, Lyme Podcast, Fred Diamond, author of "Love, Hope, Lyme: What Family Members, Partners, and Friends Who Love a Chronic Lyme Survivor" sits down with Dr. Jennifer Miller, who oversees clinical and scientific operations at Galaxy Diagnostics, for one of the most important conversations we've ever had about Lyme disease. We discuss the basics. Not just what Lyme does, but why it happens in the first place. Dr. Miller brings decades of deep scientific experience studying Borrelia burgdorferi and explains: ✅ How ticks actually become infected ✅ Why nymph ("seed") ticks are the biggest threat to humans ✅ What happens biologically inside the tick and inside your body ✅ Why Borrelia is so hard for the immune system (and antibiotics) to find ✅ How co-infections like Bartonella and Babesia complicate diagnosis and recovery ✅ Why some people develop neurological symptoms while others don't ✅ Why today's antibody tests often miss active infections and how Galaxy is working on direct detection methods to change the standard of care We also talk about:
Botox toxicity. Breast implant illness. Immune system reactivity. Post-COVID inflammation. In this episode of The Health Revival Show, we break down the real science behind cosmetic procedures and why some people tolerate Botox and breast implants perfectly… while others develop systemic symptoms. We cover: • How Botox works as a neurotoxin • Breast implant illness vs immune reactivity • Terrain theory and why host health matters more than exposure • Genetic detox pathways and inflammatory risk markers • Mast cell activation, histamine intolerance, and post-viral sensitivity • When cosmetic procedures are lower risk — and when to wait If you've ever wondered whether Botox or implants are “toxic”… this conversation will change how you think about risk, immunity, and personalized health decisions. *** CONNECT:
Two-year study reveals the startling impact that playing in nature has on children's immune systems, and their likelihood of developing allergies and diseases such as asthma and diabetes. Researcher Marja Roslund talks about the dramatic changes they measured in children's ability to fight off illnesses and the reduction in harmful bacteria found in their gut, after they rewilded the children's daycare centres, bringing in soil, plants and even a section of forest floor. She also explains the causal link between the explosion in allergies and conditions such as asthma and diabetes, and the changes we can make to make a difference. Learn more about your ad choices. Visit podcastchoices.com/adchoices
In this episode, we review the high-yield topic of Small Vessel Vasculitides without Immune Complexes from the Cardiovascular section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode:00:46 The immune cells that eat waste fats from fruit flies' brainsNature: Cho et al.10:21 Research HighlightsNature: Beetle is locked into an eternal dance ― with an antNature: Super-sniffer aeroplane finds oil fields' hidden emissions12:41 Ancient DNA evidence reveals a nuanced story of the Bell Beaker ExpansionNature: Olalde et al.Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.
Can fasting actually weaken cancer — and make chemotherapy work better?In this episode of Integrative Cancer Solutions, Dr. K sits down with longevity and nutrition science pioneer Dr. Joseph Antoun to break down the emerging research on fasting, fasting-mimicking diets, and precision nutrition for cancer. Dr. Antoun explains why cancer thrives on growth signals, how traditional “eat more calories” advice may backfire, and what the science really says about starving cancer while protecting healthy cells.This conversation explores fasting-mimicking nutrition before chemotherapy, immune rejuvenation, autophagy, growth factors like insulin and IGF-1, muscle preservation, and why food-as-medicine may dramatically improve treatment tolerance and outcomes. If you or someone you love is navigating cancer — or wants to reduce risk through longevity-based nutrition — this episode delivers critical, science-backed insights you won't hear in a standard oncology visit.Key Takeaways:0:00 Introduction and why nutrition matters in cancer6:10 Starving cancer while protecting healthy cells9:20 Fasting-mimicking diets vs water fasting12:45 How fasting sensitizes cancer to chemotherapy16:30 Immune system rejuvenation and autophagy explained21:00 Nutrition strategies after cancer treatment for longevityResources Mentioned:L-Nutra / ProLon® Fasting Mimicking Diet - https://www.l-nutra.comL-Nutra Health – Diabetes & Nutrition Programs - https://www.lnutrahealth.comThe Longevity Diet by Valter Longo - https://www.valterlongo.comCREATE Cures Foundation (USC Longevity Clinics) - https://createcures.org -----------------------------------------------A Better Way to Treat Cancer: A Comprehensive Guide to Understanding, Preventing and Most Effectively Treating Our Biggest Health ThreatGrab my book here: https://www.amazon.com/dp/B0CM1KKD9X?ref_=pe_3052080_397514860 Unleashing 10X Power: A Revolutionary Approach to Conquering CancerGet it here: https://store.thekarlfeldtcenter.com/products/unleashing-10x-powerPrice: $24.99100% Off Discount Code: CANCERPODCAST1 Healing Within: Unraveling the Emotional Roots of CancerGet it here: https://store.thekarlfeldtcenter.com/products/healing-withinPrice: $24.99100% Off Discount Code: CANCERPODCAST2-----------------------------------------------Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com
Leslie Berg talks about her career studying T cell receptor signaling, T cell development, and the importance of mentors in her career. Host: Cindy Leifer Guest: Leslie Berg Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Berg lab at University of Colorado Anschutz TCR thresholds and ITK (PNAS) Review on TCR signaling (Nat Immunol) Generation of TCR transgenic mice (Mol Cell Bio) T cell negative selection in TCR transgenic mice (Nature) Thymic exit of mature T cells in TCR transgenic mice (Cell) AAI past president Berg information Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.