Podcasts about Immunity

Episode 159 has themes of: Anxiety, Depression, Holistic Nutrition, The Business of Health Care, Gut Health, Microbiome, Perspectives, Intuitive Awareness, Self Awareness, Gut destroyers, Medical Conditioning, Alternative Health, Root cause healing, Immunity, corporate narratives. Guest: Taylor GendronFollow here on Instagram: www.instagram.com/tay.gendronVisit here website at: www.taygendron.comFor too long, corporate narrative with financial interest have been controlling the narratives of our health. We have been conditioned to put our trust in a “health care system” to make us healthier, and fix us, and heal us… and yet, our society is slowly by surely getting sicker and living with chronic disease longer. These corporate narratives call them “age related” diseases and make very compelling arguments to support this. SO let me ask you this… If the health care system is making us healthier, then why are we becoming a society that is becoming more and more chronically ill?Google “Is chronic disease on the rise” and get this answer:Of the population of people in the US 50 years and older, the number with at least one chronic disease is estimated to increase by 99.5% from 71.52 million in 2020 to 142.66 million by 2050.My question to you is, do you want to be part of that statistic. If the answer is no, then maybe looking to the holistic community is the option for you to learn some alternative tools for a health mind and body.Taylor Gendron is a holistic nutritionist, certified yoga & mediation teacher, and NLP Practitioner specializing in natural anxiety management. In other words, she's the Anxiety Nutritionist.Taylors work is rooted in prevent and even reversing mental health concerns through the combination of nutritional protocols, and NLP lifestyle coaching to help women tackle their anxiety without medication.Anxiety among many other mental health conditions are lifestyle conditions. Their symptoms can be managed by taking a pill, HOWEVER, they can be HEALED by tackling the root cause.Imagine you have extreme anxiety and you learn tools and steps to listen to your body in a different way and heal yourself? Imagine that! This is the power you have, and conversations like this one are key to shifting your perspective on how you see health, gut health, understanding YOUR body, and shifting what's actually going on.Taylor's approach is extremely compassionate as she too suffered from insurmountable anxiety, which she cured 100% (by the way) through exploring the gut, gut health and paying attention to symptoms from a “what is my body trying to tell me” lens. Her signature program and podcast named “Breaking Up with Anxiety” is a fast growing community as more and more people are WAKING UP!!! Taylor is a HUGE figure in the awakened community, so if you are hearing the whispers and are ready to take your health into your own hands… this episode is for you!For all the links to all things Elisa Unfiltered, go to:www.elisaunfilteredcoaching.com

Dr. Jeffrey Kopin, Chief Medical Officer for Northwestern Medicine Lake Forest Hospital, joins John Williams to talk about when adults should get their first colonoscopy, how time impacts immunity following a vaccine, and the importance of getting your bivalent booster. Dr. Kopin also answers all of your medical questions.

Dr. Jeffrey Kopin, Chief Medical Officer for Northwestern Medicine Lake Forest Hospital, joins John Williams to talk about when adults should get their first colonoscopy, how time impacts immunity following a vaccine, and the importance of getting your bivalent booster. Dr. Kopin also answers all of your medical questions.

Dr. Jeffrey Kopin, Chief Medical Officer for Northwestern Medicine Lake Forest Hospital, joins John Williams to talk about when adults should get their first colonoscopy, how time impacts immunity following a vaccine, and the importance of getting your bivalent booster. Dr. Kopin also answers all of your medical questions.

On this episode of Gin and Justice, the gals first go over some cocktail recipes, then they chat with David Beers.  David served in the United States Marine Corps, New York State Police as a trooper where he worked his way up to investigator, was wrongfully accused, then cleared of wrongdoing, before eventually going private. With his collective experience as a police officer, defendant, and now as a private investigator, Beers developed a unique perspective of the criminal justice system. Starting from scratch, he organized and started his own investigative business he would justly name; New Perspective Investigations, specializing in criminal defense investigation and consulting. Since then, he has worked on numerous high-profile murder cases, including the ones he now writes about. For more on David and to purchase the books:https://www.davidmbeers.com/Don't forget to leave us a review and follow us on social media!https://www.ginandjusticepodcast.comhttps://www.facebook.com/GinAndJustice/IG: @ginandjusticepodcastTwitter: Gin_JusticePodTikTok: Gin_and_Justice

***Link to HHS.com weekly written policy brief: https://hhs.com/policybrief.php Debt Limit Deal Signed into Law Durbin Urges FDA to Address Cancer Drug Shortages Utah Representative Chris Stewart Announces Resignation Biden Expected to Appoint Mandy Cohen to Lead CDC 96% of Americans Have Some Level of COVID-19 Immunity

Tony Shields, CEO and co-founder of FreshCap Mushrooms and the host of the FreshCap YouTube Channel, joins Jillian this week to talk about the power of functional mushrooms on everything from immunity to neurogenesis, serenity to energy, gut health to a source of anti-oxidants. We explore reishi's ability to help manage stress and boost mood; turkey tail's benefit to the microbiome and the up-regulation of our immune system against diseases like cancer; the Stamets mushroom stack (lions mane, kibensis, and niacin) for preventing dementia and overall cognitive function; the power of cordyceps to power our workouts; chaga's ability to support healthy cholesterol levels and lower LDL. Tony explains which types of mushroom supplements are best, from the fruiting body to mycelium, and the proper mushrooms extraction process so we buy the best quality product for the greatest effects. Plus, Tony answers listener questions on the best mushroom stacks, psilocybin strains, mushroom coffee, the benefits of gourmet mushrooms like maitaki and enochi, whether or not mushrooms have an actual language, and so much more! Guest Links:Twitter: @freshcaptonyInstagram: @freshcapmushrooms YouTube @freshcapmushrooms Website: freshcap.comFor 25% off The Fitness App by Jillian Michaels, go to www.thefitnessapp.com/podcastdealFollow us on Instagram @JillianMichaels and @MartiniCindyJillian Michaels Community: https://www.facebook.com/groups/1880466198675549Email your questions to JillianPodcast@gmail.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

LISTEN In his From the Heart segment, Dr. Paul shares how his journey through incredible struggle has led him to a place of peace and hope. It took walking through the darkness of losing his license and marriage and fighting to keep his practice afloat for him to face down his fear and overcome it finally. Only when he started to release his ego and listen to his heart did opportunity and new direction become clear. If we can put faith forward while rejecting fear, we will find that hope [...]

John Coffee, a professor at Columbia Law School and an expert in business law, discusses the Second Circuit Court of Appeals, approving Purdue Pharma's $6 billion opioid settlement proposal, and protecting the company's billionaire owners from future lawsuits. Madlin Mekelburg, Bloomberg News Texas legal reporter, discusses the impeachment of Texas Attorney General Ken Paxton. June Grasso hosts.See omnystudio.com/listener for privacy information.

South Africa grants diplomatic immunity to officials attending the BRICS summit in August.  Russian President Vladmir Putin is expected to attend. Also, Uganda's President Museveni reacts to Ugandan Troops killed by Al-Shabab militants in Somalia. And we'll find out how incessant illegal gold and diamond mining is polluting rivers in Sierra Leone. Those stories and more in this podcast with Karnie Sharp.

This week, Joy chats with Julia Edgely, an internationally practicing and licensed homeopath. She believes education and knowledge are the keys to helping her patients embrace their wellness journey, which she does through her practice and dynamic social media presence. She focuses her practice on helping her clients avoid and recover from antibiotic misuse while supporting natural immune function. In order to help her patients regain their natural immunity and health, she developed her signature ABC Method, which has helped hundreds of individuals and families eliminate unnecessary antibiotics. In this episode Julia shares her wealth of knowledge on what constitutes antibiotic misuse and the common signs to look out for. Her knowledge of the innate and adaptive immune system and its interconnection with the microbiome will empower you with the knowledge to trust your intuition when it comes to healing. She also outlines tons of simple, actionable tips to help support natural immune function that you can incorporate right away. You'll love her practical tips and vibrant energy! If you want to learn how to recover from antibiotic overuse or misuse to naturally support your immune system, then you won't want to miss this episode. So settle in with a cuppa your favourite restorative tea and get ready to be inspired to take control of your health!   Episode Highlights: How Julia became interested in homeopathy at a young age.  The importance of food for healing & improving immunity. How homeopathic treatment is based on unique symptoms to find your perfect remedy. The difference between acute and constitutional homeopathy. The link between antibiotic misuse/overuse & immune dysfunction.  The definition of antibiotic overuse and misuse.  How knowledge can empower you to make the right decisions for your health.  Consequences of overuse and misuse of antibiotics.  How antibiotic use in the first few years of life can impact your microbiome.  What is the difference between innate and adaptive immunity? How do antibiotics impact the immune system and microbiome? The function of a fever for healing + red flag symptoms to watch for.  Suggestions for parents to make children more comfortable during a fever.  Concerns with overuse of OTC medications.  Tools she uses to help her clients resolve their health conditions & support immunity.  How to use the ABC method to support acute illness.  Lifestyle habits that can help support the immune system.  The power of bone broth!  Some unknown side-effects of antibiotics.    Resources: Julia's Website Julia's Instagram Julia's Twitter Julia's Facebook The ABC Method Book an Appointment FREE Immune Remedies EBook FREE Immunity Toolkit Video Sign Up for Julia's Newsletter   More about Joyous Health: Check out our award-winning blog Joyous Health Check out  Joy's bestselling cookbooks Sign up for the Joyous Health newsletter Follow Joyous Health on Instagram Find Joyous Health on Facebook Learn more about The Joyous Health Business Program Check out our full line of Natural & Organic Haircare and Body Care. Join Joy's Hair Care Challenge at Natural Hair Care Challenge Explore Joyous Health Kids at Joyous Health Kids  

Note: It is important to consult a healthcare professional if you suspect you have health concerns or if you experience any unusual symptoms. These natural remedies should be used as complementary therapies and should not replace medical treatment. All these QueenTalkLA Podcast are for educational purposes only. Please leave a review and it helps the algorithm know that this content matters. We would love to welcome you as an exclusive subscriber. Check out the bio for more details It's important to note that while these natural herbs may offer potential health benefits, they should not be used as a substitute for medical advice and treatment. It's always a good idea to talk to your healthcare provider before using any herbs or supplements, especially if you have any underlying medical conditions or are taking any medications. --- Send in a voice message: https://podcasters.spotify.com/pod/show/queentalkla/message

LISTENBe sure to check out the full interview with DeeDee Hoover & Sonja Feintech a Members Only exclusive!Watch the full interview here.In his From the Heart segment, Dr. Paul dedicates this show to Dr. Rashid Buttar, an amazing leader in our health freedom movement who unexpectedly passed away. He reflects on Dr. Buttar's powerful message about fear and love. Dr. Buttar challenged us to examine our hearts daily to see whether we are making decisions from a place of fear…or love. Acknow [...]

Exercise is a remarkable thing for our bodies. If you are looking for the motivation to start or restart your favorite exercise regimen, this is the episode for you! Listen in to learn about the many magical things that exercise does for you including some benefits you probably haven't heard before. Episode Highlights: Exercise for weight management, mood, mental health, and cognition How exercise helps bone density Moderate vs high intensity exercise Why cardiovascular health is important Immunity benefits of exercise Work with Dr. Brooke Stubbs ⁠⁠⁠⁠⁠⁠https://www.rootedfemme.com/⁠⁠⁠⁠⁠⁠ Follow Dr. Brooke Stubbs and That Rooted Feeling on Instagram: @brookiestubbsmd ⁠⁠⁠⁠https://www.instagram.com/brookiestubbsmd/⁠⁠⁠⁠ and @thatrootedfeeling ⁠⁠⁠⁠⁠⁠https://www.instagram.com/thatrootedfeeling/⁠

Today we visit with Dr Cynthia Green. Dr. Green is a leading brain health expert who is passionate about making the brain health science accessible, sustainable, and fun for all. A clinical psychologist and assistant clinical professor of psychiatry at the Mt. Sinai School of Medicine. Dr. Green is the president of Total Brain Health, a leading provider of brain wellness training. She has authored 6 books on the topic, including Your Best Brain Ever, which was named a “2013 Top Guide to Life after 50” by the Wall Street Journal. Dr. Green is a regular media guest whose work has been featured on Good Morning America, 20/20, CNBC, Fox, The Martha Stewart Show, The New York Times, The Washington Post, and Good Housekeeping among others and she shares some great insights into this important topic.

Vitamin D3 is USELESS unless it's taken with these 2 other supplements. Has your doctor discussed this with you?

Here are the notes for episode #429 of Well-Fed Women. Be sure to check back every Tuesday for a new episode, and head over to Apple Podcasts or Stitcher to subscribe!In this episode, Noelle and Dr. Elisa Song discuss a holistic spproach to kids immunity, allergies, antibiotic use, and behavioral issues. Got a question you'd like us to answer? Email us at wellfedwomen@gmail.com.5% of the funds we receive from our sponsors is donated directly to our partner charity, Thistle Farms, a place where women survivors of abuse, addiction, trafficking and prostitution receive help and support through residential programs, therapy, education, and employment opportunities. Because we get paid per download, you are actively supporting Thistle Farms by downloading our podcast each week.Timestamps[4:43] Interview with Dr. Elisa SongLinkshttps://healthykidshappykids.com/ www.healthykidshappykids.comhttps://www.instagram.com/healthykids_happykids/Shop her supplementsHMO Human Milk OligosaccharideLactobacillus acidophilus NCFMBifidobacterium lactis Bi-07Immune Probiotichttps://healthykidshappykids.com/ Vitamin D3 +K2Omega-3 SynergyNordic Naturals Children's DHABarlean's Omega-3 Fish OilZincGlutathioneEpsom SaltV Clear EPs 7630 CherryUmcka Coldcare KidsBoiron OscillococcinumLarge intestine 4 – press on this or add lavenderWindbreakerGaia Herbs Quick Defense (for Adults)Wishgarden HerbsKids Garlic Ear OilQuercetin SynergyAllergyCalm (adults)AllergyCalm KidsBoiron Optique 1 Eye DropsTop 10 Holistic Remedies for Your Child's AllergiesTop 10 Ways to Lower Your Child's Allergy BucketKlaire Labs Mood Probiotic Powder Target gb-X Pycnogenol® - Pine Bark ExtractLMNTLMNT makes grab and go electrolyte replacement supplementation. You just take an LMNT recharge packet, mix it up with water, and sip! Ther

LISTEN In his From the Heart segment, Dr. Paul asks us to think about what we imagine and hope for our future. What do we want to come true? Dr. Paul imagines a world where kids are born healthy and stay healthy…naturally. He wants a world where everyone gets along with no hate or division…just love. He invites us to join him in imagining such a world…if we can imagine it, we are more likely to make it come true! Breaking the Oath exposes the dark reality of incenti [...]

https://lewishowes.com/mindset - Order a copy of my new book The Greatness Mindset today!Based in Seattle, Washington, Dr. Jeffrey Bland is a world-renowned nutritional medicine expert, “father of Functional Medicine”, and founder of Big Bold Health, a company on a mission to transform the way people think about one of nature's greatest innovations — the immune system. Jeffrey is advocating for the power of Immuno-Rejuvenation to enhance immunity at a global level, often through the rediscovery of ancient food crops and superfoods. To get there, Jeffrey is building a network of small farms and suppliers throughout the US that take a clear stance on regenerative agriculture, environmental stewardship, and planetary health. Jeffrey's career in health spans more than 40 years. In this episode you will learn,Valuable insights on how nutrition can strengthen the immune system and prevent chronic diseases.The importance of adopting a personalized approach to nutrition, considering factors such as genetics, lifestyle, and environmental influences.The role of specific nutrients, such as vitamins, minerals, and antioxidants, in supporting immune function and overall health.The significance of maintaining a balanced gut microbiome and shares practical tips for optimizing digestive health.Valuable knowledge and actionable strategies to enhance their immunity and promote long-term well-being through proper nutrition.For more information go to www.lewishowes.com/1442Casey Means: https://link.chtbl.com/1252-podDaniel Amen: https://link.chtbl.com/1243-podDavid Sinclair: https://link.chtbl.com/1232-pod

Dr. Amy Shah is on this week to share the keys for resetting our circadian rhythm and explain how doing so can improve every aspect of our health. Circadian rhythms direct the function of every cell in our body, thereby impacting ideal hormone balance, healthy weight, excellent sleep, a strong immune system and so much more! Get to know the 6 pillars of resetting your circadian rhythms to find the ideal times to eat, train, and sleep!Guest Links:Website: https://amymdwellness.comInstagram: @fastingmdTwitter & Facebook: @amyshahmdBooks:· I'm So Effing Hungry: Why We Crave – and What to Do About It· I'm So Effing Tired: A Proven Plan to Beat Burnout, Boost Your Energy, and Reclaim Your LifeFor 25% off The Fitness App by Jillian Michaels, go to www.thefitnessapp.com/podcastdealFollow us on Instagram @JillianMichaels and @MartiniCindyJillian Michaels Community: https://www.facebook.com/groups/1880466198675549Email your questions to JillianPodcast@gmail.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On today's Whole Story Health Hour radio show/podcast, we breakdown some of the "behind the scenes" causes for food sensitivities. We also discuss how this affects your health, how common medications can negatively impact your health and even discuss some of the things our kids are facing due to toxins and food sensitivities. This episode is packed full of interesting and incredibly useful information. If you found this helpful, it would help us if you will subscribe to, rate and review the show. And as always, thanks for spending your time with me. Are you a woman struggling with hormone-related fatigue, stubborn weight gain, anxiety and/or irregular cycles? Contact me at wholestoryhealth@gmail.com or DM me @allisonhealthcoachnooe on Instagram to chat about possible solutions.  Connect with Kim Strong on: www.truthintegrativemedicine.com, truthintegrativemedicine@gmail.com, Twitter @truthintegrativ, Instagram @truthintegrativ, facebook @truthintegrativemedicine or call 601-882-5801 to schedule your appointment.

This week Attorney Samantha Drum is here sharing tools she's learned dealing with high conflict situations and managing the anxiety around standing up for yourself. Thank you for all the incredible support over these past 5 years. This time has gone so quick and it's a testament to our incredible listeners, guests, rotating cast of co-hosts and ever present producer Pete Murtagh that we're still going… There's loads more planned ahead of our 300th episode so keep an eye on the feed in the coming weeks

You've seen celebrities with facelifts that leave them with an odd, unnatural look–like their face has been pulled too tight. That's because facelifts, which have been around for over 100 years, have traditionally always been the excision (cutting and removal) of tissue. For so long, excision was THE only option. With today's advanced technologies, there is a better solution, and I'm discussing it in this episode. Join me to learn more about the no-cut facelift that has no cuts, no scars, and delivers better results and faster healing! Show Highlights: Three components of facial aging addressed by a facelift: loss of facial bone, loss of fatty volume, and skin laxity How radio frequency devices came on the facelift scene—but didn't solve the problem How we are leveraging no-cut technology called Ellacor to improve jawlines and deliver superior facelift results with minimal post-procedure redness How we use exosomes to enhance wound healing How we are personalizing treatment by using stem cells from the patient's fat (extracted about 8 weeks before the no-cut facelift) How red light therapy, an upright hyperbaric chamber, and IV therapy are used to accelerate healing—all in the office How the no-cut facelift requires only 4-5 days of downtime, with slowly disappearing tiny, pigmented areas able to be covered with makeup after a few days of healing How no-cut technology is also used on breasts arms, abdomen, buttocks, thighs, knees, etc. with similar results *Links: * Follow Dr. Rob on Instagram (https://www.instagram.com/drrobertwhitfield/) Learn more about skin tightening with Dr. Rob (https://www.drrobertwhitfield.com/minimally-invasive-procedures) *About Dr. Rob's Solution Podcast * Austin's natural plastic surgeon Dr. Robert Whitfield brings you the true stories of actual patients, navigates through their surgical and non-surgical treatment options, then reveals their chosen path forward and the results they achieved. Dr. Rob is a board certified plastic surgeon and Austin's Natural Choice for plastic surgery, laser and energy treatments, and aesthetics. Visit Dr. Rob's Austin plastic surgery (https://www.drrobertwhitfield.com/) practice website or follow him on Instagram at @drrobertwhitfield (https://www.instagram.com/drrobertwhitfield/) Holistic + Scientific is a production of The Axis. (http://www.theaxis.io/) Host: Robert Whitfield, MD Executive Producer: Eva Sheie Editor and Audio Engineer: Daniel Croeser Theme Music: A Minute Too Early, Arc de Soleil Production Assistant: Mary Ellen Clarkson Cover Art Designer: Shawn Hiatt PROUDLY MADE IN AUSTIN, TEXAS

This month on Episode 48 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the April 28th issue of Circulation Research. This Episode also includes a discussion between Dr Mina Chung, Dr DeLisa Fairweather and Dr Milka Koupenova, who all contributed to manuscripts to the May 12th Compendium on Covid-19 and the Cardiovascular System.     Article highlights:   Heijman, et al. Mechanisms of Enhanced SK-Channel Current in AF   Chen, et al. IL-37 Attenuates Platelet Activation   Enzan, et al. ZBP1 Protects Against Myocardial Inflammation   Compendium on Covid-19 and the Cardiovascular System.   Cindy St. Hilaire: Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh. Today, I'm going to be highlighting articles from our April 28th and May 12th issues of Circulation Research. I'm also going to have a chat with Dr Mina Chung, Dr DeLisa Fairweather and Dr Milka Koupenova, who all contributed to articles in the May 12th COVID Compendium. But before we have that interview, let's first talk about some highlights.   The first article I want to present is titled Enhanced Calcium-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation. This article is coming from the University of Essen by Heijman and Zhou, et al. Atrial fibrillation is one of the most common forms of heart arrhythmia in humans and is characterized by irregular, often rapid heartbeats that can cause palpitations, dizziness and extreme fatigue. Atrial fibrillation can increase a person's risk of heart failure, and though treatments exist such as beta blockers, blood thinners and antiarrhythmia medications, they can have limited efficacy and side effects. A new family of drugs in development are those blocking small-conductance calcium-activated potassium channels called SK channels, which exhibit increased activity in animal models of AF and suppression of which attenuates the arrhythmia. In humans however, the relationship between SK channels and atrial fibrillation is less clear, at least in terms of SK channel mRNA levels. Because mRNA might not reflect actual channel activity, this group looked at just that and they found indeed that channel activity was increased in cardiomyocytes from atrial fibrillation patients compared to those from controls even though the mRNA and protein levels themselves were similar. The altered currents were instead due to changes in SK channel trafficking and membrane targeting. By confirming that SK channels play a role in human atrial fibrillation, this work supports the pursuit of SK channel inhibitors as possible new atrial fibrillation treatments.   The next article I want to present is titled IL-37 Attenuates Platelet Activation and Thrombosis Through IL-1R8 Pathway. This article comes from Fudan University by Chen and Hong, et al. Thrombus formation followed by the rupture of a coronary plaque is a major pathophysiological step in the development of a myocardial infarction. Understanding the endogenous antithrombotic factors at play could provide insights and opportunities for developing treatments. With this in mind, Chen and Hong, et al. investigated the role of interleukin-1 receptor 8, or IL-1R8, which suppresses platelet aggregation in mice, and of IL-37, a newly discovered human interleukin that forms a complex with IL-1R8 and is found at increased levels in the blood of patients with myocardial infarction. Indeed, the amount of IL-37 in myocardial infarction patients negatively correlates with platelet aggregation. They also show that treatment of human platelets in vitro with IL-37 suppresses the cell's aggregation and does so in a concentration-dependent manner. Moreover, injection of the protein into the veins of mice inhibits thrombus development and better preserves heart function even after myocardial infarction. Such effects were not seen in mice lacking IL-1R8. This suggests IL-37's antithrombotic action depends on its interaction with the receptor. Together, the results suggest IL-37 could be developed as a antithrombotic agent for use in MI patients or indeed perhaps other thrombotic conditions.   The last article I want to present before our interview is titled ZBP1 Protects Against Mitochondrial DNA-Induced Myocardial Inflammation in Failing Hearts. This article is coming from Kyushu University and is by Enzan, et al. Myocardial inflammation is a key factor in the pathological progression of heart failure and occurs when damaged mitochondria within the stricken cardiomyocyte release their DNA, triggering an innate inflammatory reaction. In a variety of cells, DNA sensors such as Z-DNA-binding protein 1 or ZBP1 are responsible for such mitochondrial DNA-induced inflammation. In theory then, it's conceivable that therapeutic suppression of ZBP1 might reduce myocardial inflammation in heart failure and preserve function. But as Enzan and colleagues have now discovered to their surprise, mice lacking ZBP1 exhibited worse, not better heart inflammation and more failure after induced myocardial infarction. Indeed, the test animals' hearts had increased infiltration of immune cells, production of inflammatory cytokines and fibrosis together with decreased function compared with the hearts of mice with normal ZBP1 levels. Experiments in rodent cardiomyocytes further confirmed that loss of ZBP1 exacerbated mitochondrial DNA-induced inflammatory cytokine production while overexpression of ZBP1 had the opposite effect. While the reason behind ZBP1's opposing roles in different cells is not yet clear, the finding suggests that boosting ZBP1 activity in the heart might be a strategy for mitigating heart inflammation after infarction.   Cindy St. Hilaire:         The May 12th issue of Circulation Research is our COVID compendium, which consists of a series of 10 reviews on all angles of COVID-19 as it relates to cardiovascular health and disease. Today, three of the authors of the articles in this series are here with me. Dr Mina Chung is a professor of medicine at the Cleveland Clinic. She and Dr Tamanna Singh and their colleagues wrote the article, A Post Pandemic Enigma: The Cardiovascular Impact of Post-Acute Sequelae of SARS-CoV-2. Dr DeLisa Fairweather, professor of medicine, immunology and clinical and translational science at the Mayo Clinic, and she and her colleagues penned the article, COVID-19 Myocarditis and Pericarditis. Dr Milka Koupenova is an assistant professor of medicine at the UMass Chan School of Medical and she led the group writing the article, Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond. Thank you all for joining me today.   DeLisa Fairweather:    Thank you so much for having us.   Mina Chung:   Thank you.   Milka Koupenova:       Thank you for having us, Cindy.   Cindy St. Hilaire:         In addition to these three articles, we have another seven that are on all different aspects of COVID. Dr Messinger's group wrote the article, Interaction of COVID-19 With Common Cardiovascular Disorders. Emily Tsai covered cell-specific mechanisms in the heart of COVID-19 patients. Mark Chappell and colleagues wrote about the renin-angiotensin system and sex differences in COVID-19. Michael Bristow covered vaccination-associated myocarditis and myocardial injury. Jow Loacalzo and colleagues covered repurposing drugs for the treatment of COVID-19 and its cardiovascular manifestations. Dr Stephen Holby covered multimodality cardiac imaging in COVID, and Arun Sharma covered microfluidic organ chips in stem cell models in the fight against COVID-19.   Cindy St. Hilaire          As of today, worldwide, there have been over six hundred million individuals infected with the virus and more than six and a half million have died from COVID-19. In the US, we are about a sixth of all of those deaths. Obviously now we're in 2023, the numbers of individuals getting infected and dying are much, much lower. As my husband read to me this morning, one doctor in Boston was quoted saying, "People are still getting wicked sick." In 75% of deaths, people have had underlying conditions and cardiovascular disease is found in about 60% of all those deaths. In the introduction to the compendium, you mentioned that the remarkable COVID-19 rapid response initiative released by the AHA, which again is the parent organization of Circ Research and this podcast, if I were to guess when that rapid response initiative started, I would've guessed well into the pandemic, but it was actually March 26th, 2020. I know in Pittsburgh, our labs have barely shut down. So how soon after we knew of SARS-CoV-2 and COVID, how soon after that did we know that there were cardiovascular complications?   Mina Chung:               I think we saw cardiovascular complications happening pretty early. We saw troponin increases very early. It was really amazing what AHA did in terms of this rapid response grant mechanism. You mentioned that the RFA was announced, first of all, putting it together by March 26th when we were just shutting down in March was pretty incredible to get even the RFA out. Then the grants were supposed to be submitted by April 6th and there were 750 grants that were put together and submitted. They were all reviewed within 10 days from 150 volunteer reviewers. The notices were distributed April 23rd, less than a month out.   Cindy St. Hilaire:         Amazing.   Mina Chung:               So this is an amazing, you're right, paradigm for grant requests and submissions and reviews.   DeLisa Fairweather:    For myocarditis, reports of that occurred almost immediately coming out of China, so it was incredibly rapid.   Cindy St. Hilaire:         Yeah, and that was a perfect lead up to my next question. Was myocarditis, I guess, the first link or the first clue that this was not just going to be a respiratory infection?   DeLisa Fairweather:    I think myocarditis appearing very early, especially it has a history both of being induced by viruses, but being strongly an autoimmune disease, the combination of both of those, I think, started to hint that something different was going to happen, although a lot of people probably didn't realize the significance of that right away.   Cindy St. Hilaire:         What other disease states, I guess I'm thinking viruses, but anything, what causes myocarditis and pericarditis normally and how unique is it that we are seeing this as a sequelae of COVID?   DeLisa Fairweather:    I think it's not surprising that we find it. Viruses around the world are the primary cause of myocarditis, although in South America, it's the parasite Trypanosoma cruzi. Really, many viruses that also we think target mitochondria, including SARS-CoV-2, have an important role in driving myocarditis. Also, we know that SARS-CoV-1 and MERS also reported myocarditis in those previous infections. We knew about it beforehand that they could cause myocarditis.   Cindy St. Hilaire:        Is it presenting differently in a COVID patient than say those South American patients with the... I forget the name of the organism you said, but does it come quickly or get worse quickly or is it all once you get it, it's the same progression?   DeLisa Fairweather:    Yeah. That's a good question. Basically, what we find is that no matter what the viral infection is, that myocarditis really appears for signs and symptoms and how we treat it identically and we see that with COVID-19. So that really isn't any different.   Cindy St. Hilaire:         Another huge observation that we noticed in COVID-19 patients, which was the increased risk of thrombic outcomes in the patients. Dr Koupenova, Milka, you are a world expert in platelets and viruses and so you and your team were leading the writing of that article. My guess is knowing what you know about platelets and viruses, this wasn't so surprising to you, but could you at least tell us the state of the field in terms of what we knew about viruses and platelets before COVID, before Feb 2020?   Milka Koupenova:       Before Feb 2020, we actually knew that influenza gets inside in platelets. It leads to not directly prothrombotic events, but it would lead to release of complement 3 from them. That complement 3 would actually increase the immunothrombosis by pushing neutrophils to release their DNA, forming aggregates. In cases when you have compromised endothelium and people with underlying conditions, you would expect certain thrombotic outcomes. That, we actually published 2019 and then 2020 hit. The difference between influenza and SARS-CoV-2, they're different viruses. They carry their genome in a different RNA strand. I remember thinking perhaps viruses are getting inside in platelets, but perhaps they do not. So we went through surprising discoveries that it seemed like it is another RNA virus. It also got into platelets. It was a bit hard to tweak things surrounding BSL-3 to tell you if the response was the same. It is still not very clear how much SARS or rather what receptor, particularly when it gets inside would induce an immune response. There are some literature showing the MDA5, but not for sure, may be responsible. But what we found is that once it gets in platelets, it just induces this profound activation of programmed cell death pathways and release of extracellular vesicles and all these prothrombotic, procoagulant form of content that can induce damage around, because platelets are everywhere. So that how it started in 2019 and surprisingly progressed to 2021 or 2020 without the plan of really studying this virus.   Cindy St. Hilaire:         How similar and how different is what you observe in platelets infected, obviously in the lab, so I know it's not exactly the same, but how similar and how different is it between the flu? Do you know all the differences yet?   Milka Koupenova:       No offense here, they don't get infected.   Cindy St. Hilaire:         Okay.   Milka Koupenova:       Done the proper research. The virus does not impact platelets, but induces the response.   Cindy St. Hilaire:         Okay.   Milka Koupenova:       That goes back to sensing mechanism. Thank goodness platelets don't get infected because we would be in a particularly bad situation, but they remove the infectious virus from the plasma from what we can see with function.   Cindy St. Hilaire:         Got it. So they're helping the cleanup process and in that cleaning up is where the virus within them activates. That is a really complicated mechanism.    Milka Koupenova:       Oh, they're sensing it in some form to alert the environment. It's hard to say how similar and how different they are unless you study them hint by hint next to each other. All I can tell is that particularly with SARS-C, you definitely see a lot more various kinds of extracellular vesicles coming out of them that you don't see the same way or rather through the same proportion with influenza. But what that means in how platelet activates the immune system with one versus the other, and that goes back to the prothrombotic mechanisms. That is exactly what needs to be studied and that was the call for this COVID compendium is to point out how much we have done as a team. As scientists who put heads together, as Mina said, superfast response, it's an amazing going back and looking at what happened to think of what we achieved. There is so much more, so much more that we do not understand how one contributes to all of these profound responses in the organs themselves, such as myocarditis. We see it's important and that will be the problem that we're dealing from here on trying to figure it out and then long COVID, right?   Cindy St. Hilaire:         Yeah. Related to what you just said about the mechanism, this cleanup by the platelets or the act of cleaning up helps trigger their activation, is that partly why the antiplatelet and anticoagulant therapies failed in patients? Can you speculate on that? I know the jury's still out and there's a lot of work to be done, but is that part of why those therapies weren't beneficial?   Milka Koupenova:       The answer to that in my personally biased opinion is yes. Clearly, the antiplatelet therapies couldn't really control the classical activation of a platelet. So what I think we need to do from here on is to look at things that we don't understand that non-classically contribute to the thrombotic response downstream. If we manage to control the immune response in some way or the inflammation of the infection or how a platelet responds to a virus, then perhaps we can ameliorate a little bit of the downstream prothrombotic effect. So it's a lot more for us to trickle down and to understand in my personal opinion.   DeLisa Fairweather:    There is one thing that was really remarkable to me in hearing your experience, Milka, is that I had developed an autoimmune viral model of myocarditis in mice during my postdoc. So I've been studying that for the last 20 years. What is unique about that model is rather than using an adjuvant, we use a mild viral infection so it doesn't take very much virus at all going to the heart to induce it. I also, more recently, started studying extracellular vesicles really as a therapy, and in doing that, inadvertently found out that actually, the model that I'd created where we passage the virus through the heart to induce this autoimmune model, we were actually injecting extracellular vesicles into the mice and that's what was really driving the disease. This is really brought out. So from early days, I did my postdoc with Dr Noel Rose. If you've heard of him, he came up with the idea of autoimmune disease in the '50s. We had always, in that environment, really believed that viruses were triggering autoimmune disease and yet it took COVID before we could really prove that because no one could identify them. Here we have an example and I think the incidence rates with COVID were so high for myocarditis because for the first time, we had distinguished symptoms of patients going to the doctor right at the beginning of their infection having an actual test to examine the virus, knowing whether it's present or not, whether PCR or antibody test, and then being able to see when myocarditis happened.   Cindy St. Hilaire:         Yeah. I think one thing we can all appreciate now is just some of the basic biology we've learned on the backend of this. Actually, those last comments really led well to the article that your team led, Dr Chung, about what we call long COVID, which I guess I didn't realize has an actual name, post-acute sequelae of SARS-CoV-2 or PASC is the now more formal name for long COVID. But what is it? We hinted at it that there's these bits about autoimmune and things like that. What counts as long COVID?   Mina Chung:   Yeah. Our article was led by Tamanna Singh. She did a fantastic job of putting this together. We've had, and others, theorized that the huge palette of symptoms that you can experience post-COVID, they can affect all these organ systems with brain fog, these atypical chest pains, postural orthostatic tachycardia, a lot of palpitations, atrial fibrillation, many weakness and fatigue. To us, really, you can get GI symptoms. We've been very interested in, is this an autoimmune phenomenon directed against nerves and all those things. It's also very interesting because many of the non-COVID syndromes that existed pre-COVID like POTS and chronic fatigue syndrome and a lot of other syndromes are associated with autoantibodies. So that is a very interesting area to explore. Is there a persistence of viral fragments. Is there autoimmunity? Is it also a component of persistence of the damage from the initial infection? So it's an area that still needs a lot of work and a lot of work is going into it, but this is like a post or inter pandemic of itself, so hopefully we'll get more insights into that.   Cindy St. Hilaire:         Yeah, it's really interesting. I have a friend who has very debilitating long COVID and one of her doctors had said, "If I didn't know any better, I would just describe this as a autoimmune type X." What do we know, I guess, about the current hypothesis of the pathogenesis of PASC? Are there any prevailing theories right now as to why it's occurring? Is the virus still active or is it these domino effects that are leading to multi-organ collapse of some sort?   Mina Chung:   Yeah. In some people, persistent viral particles can be identified for months, but whether or not that's what's triggering it, it's hard to know. We see more autoimmune disease that's been reported and various antibodies being reported. So those are clearly processes to be investigated. The microthrombosis is still up there in terms of potentially playing a role in long COVID.   Milka Koupenova:       Mina, you probably know better because you see patients, but to all I have been exposed to, long COVID does not really have a homogeneous symptom presentation and then a few theories as to what may be going on in these patients. Not everybody has a microthrombosis. Not everybody have a D-dimer elevated, but some people do. Some people have, as you pointed out, these spectacularly profound brain fog. People can't function. It's probably your friend, Cindy, right?   Cindy St. Hilaire:         Yeah.   Milka Koupenova:       So one of the theories that I have been, from a viral perspective, very interested in is that a lot of the symptoms in certain individuals such as fatigue, brain fog, sensitivity to light and skin can very well be explained by a flare-up of Epstein-Barr virus that may be what SARS-CoV-2 somehow is inducing. I don't know, DeLisa, what your experience with long COVID is as a scientist. I hope only. But I would like to hear your perspective too because it's so heterogeneous and it is amazing what happens.   DeLisa Fairweather:    I have a very interesting perspective from a number of different directions. One, as I mentioned before, my long history with Dr Rose and I've written many articles theorizing how viruses could cause autoimmune disease. This has grown and really, I think this has been extremely revealing during COVID for many of those theories. One thing that I write about in the review for this article is that mast cells, from all the research I've done with myocarditis in our model, mast cells are central to what is driving everything. We show they're the first innate immune cell acting as an antigen-presenting cell, completely driving the response in a susceptible pattern. One of the things that's very important in autoimmune disease is both sex and race. I'd say one of the big weaknesses we have in myocarditis pre-COVID and post-COVID has been ignoring what's going on with race. In the United States, myocarditis is 90%, 95% white men that are under 50 years of age and most of the cases are under 40 or some of the ones really associated with sudden cardiac death are under 30. So it's very specific. I've been studying sex and race differences and we see those exact differences in our animal models. In animal models, whether you're susceptible or not depends on how many mast cells you have. Well, I've proposed from the beginning, looking, I've written a lot of different sex difference reviews looking at viruses and autoimmune disease with different autoimmune diseases and hypothesizing and really seeing that mast cells do a lot of the things we're talking about. They have all of the receptors, the whole group of them that have been related to SARS-CoV-2 so they can be activated or stimulated by the virus itself. They act as a antigen-presenting cell. They're critical in the complement pathway as well as macrophages. We see the dominant immune phenotype really being macrophages. Mast cells just are usually not counted anywhere. And of course, these receptors, a lot of them have to do with enzymes and things that are all related to mast cells pathways. Then how they activate the immune response and lead it towards the pathway that leads to chronic autoimmune disease with increased autoantibodies in females, mast cells are very different by sex. This has to do also when we talked in the Review about myocarditis and pericarditis. It's both those appearing. Although clinically, we have really boxed them as separate things, because there is some definite clinical pericarditis phenotypes that are different, myocarditis in animal models is always myopericarditis. It always then, in that outer pericardial areas where mast cells sit, they sit around the vascular area in most concentrated. So when they degranulate, we see inflammation coming in the vessel, but really concentrated with fibrosis there and along the pericardium. So that's very typical of what's going on. When we shift anything that shifts that, it changes whether you have more pericarditis or less pericarditis and the vascular inflammation by altering anything that affects the mast cells. I talk a little bit about in the review, I think there's only been a few recent things looking at it in COVID, but I think mast cells and certain susceptibility to autoimmune diseases that occur more often in women can really predispose.We need to pay more attention to mast cells and what they might indicate for all these pathways.   Milka Koupenova:       I think we should study the platelet mast cell access at this point.   DeLisa Fairweather:    Yes.   Milka Koupenova:       Because as you're talking about these sex differences, which is spectacular, these things to me are so mind-boggling how one, the infection itself would be more prevalent in men, but then long COVID is more prevalent in women. All of these things and why we understand so very little, what we found about a few years ago in the Framingham Heart Study in the platelets from those people is that all toll-like receptors are expressed at the higher level in women and they associate with different things between men and female. For instance, toll-like receptors in women will associate more with a prothrombotic response while in male with pro-inflammatory response. I think they grossly underestimate the amount of our sex differences from cell to cell.   DeLisa Fairweather:    It is, yeah.   Mina Chung:   One other thing that I learned about the sex differences from this compendium is Mark Chappell also notes, you mentioned TLR and TLR7 and ACE2 are X chromosome in an area that he says escapes X-linked inactivation. So it could very well be involved in further.   DeLisa Fairweather: Further, yeah. And ACE2 is expressed more highly in male cells for what's been researched because of the sex difference in COVID, both the COVID infection   Cindy St. Hilaire:         So a variety of organ systems are impacted in patients with PASC, also referred to as long COVID, the lungs, the heart, the pancreas, the GI system, pretty much any system, the brain, nervous system. We've just been talking about the mast cell impact. I was really thinking in my head, well, the one thing that connects all of it is the vasculature. I'm a vascular biologist, so I have certain biases, I'm sure, but how much of the sequelae that we see is a function of vascular phenotypes?       Milka Koupenova:       I do think the vasculature is super important. It's clear that not all endothelial cells, for instance, will pick up the virus and respond to it. That's why you have this patchy breakage when you look at autopsies. Hence, platelets will respond according to what's local. That's why you find these micro thrombotic events at certain places. Why does it happen in each organ? How does the virus get to each organ to respond? Or is it just inflammation, but why is it in specific places? That's what we don't understand. That's where we need to go. Perhaps, as DeLisa points out, perhaps it's a lot more complicated than how we traditionally think of thrombosis. Actually, my personal bias, again 100% sure that it is a lot more complicated than the traditional mechanisms that we have understood, and that's where the immune system comes and autoimmunity perhaps stems from and they probably speak to each other, right? It's not just one thing.   DeLisa Fairweather:    Yeah. I think really, EVs are bringing lots of understanding. A lot of things we used to just think were maybe free-floating and the serum are inside EVs. I think that the immune response is perhaps even more specific than we ever thought and more regulated than we ever understood.   When an EV comes through a cardiomyocyte, whether it's from the mitochondria or through a lysosome, is part of what goes into its outer membrane, something that tells the immune system that that came from the heart, so it knows to go. This will solve a lot of our questions with autoimmune disease if it's very specific like that. It doesn't just have to be the release of free-floating cardiac myosin. We know cardiac myosin is the driver of the autoimmune response in myocarditis, but they're probably  much more fine-tuned.   Cindy St. Hilaire:         Yeah. I just would love to end with hearing from each of you. You each have your own domain of specialty. If I gave you a massive pot of money, what would be the question you would want to tackle? What's the gap you would love to answer?   Milka Koupenova:       We still don't understand specifically what kind of vesicles are coming out, what are their contents in addition to those vesicles. We don't understand. When it comes to platelets, what comes from their granules? We see these breakages of the membrane. Those are non-granule proteins, and non-granule proteins, they serve as dangerous associated molecular pattern signals and can be profoundly inflammatory to the surrounding environment, can be procoagulant. What are those? How are they affecting the surrounding environment? Ultimately, why is there a microthrombi? Why is there not a profound thrombosis everywhere? Thank goodness there isn't, but why isn't? That's what I would do with my money.   DeLisa Fairweather:    I think I would do something very similar. All of our research in our animal model, on the one side, we are looking in this viral myocarditis animal model and finding the EVs that come from that are driving myocarditis. On the other hand, we're using EVs that come from healthy human plasma or fat, and we're seeing a profound downregulation of everything if you give it early and we're trying to see how late you can give it and still get an effect. So looking at those and really understanding the components in the context of COVID and COVID vaccines to understand those components, I really think that's the future of where we're going to find what's causing disease and also how we can find therapies. They may be able to reverse this.   Mina Chung:   Yeah, I'm interested very much in the autoimmunity and the autoantibodies that are    and how they may react with those microthrombi. Perhaps there's autoantibodies within a lot of that material. We're looking at using human and pluripotent stem cell-derived cell models to study the effects of those. That is what I would use our money for.   Cindy St. Hilaire:        Well, Dr Mina Chung, Dr DeLisa Fairweather, Dr Milka Koupenova, thank you all so much for joining me today and talking about not only the articles that you wrote and with your colleagues, but also other articles in this amazing compendium. I do think this is one of the first all-encompassing compendiums or group of articles that focus specifically on COVID and cardiovascular disease. So thank you all so much.   Mina Chung:   Thank you.   DeLisa Fairweather:    Thank you.   Milka Koupenova:       You're welcome.   Cindy St. Hilaire:         That's it for highlights from the April 28th and May 12th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @circres and #DiscoverCircRes. Thank you to our guests, Dr Mina Chung, Dr DeLisa Fairweather and Dr Milka Koupenova. This podcast is produced by Ishara Ratnayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on-the-go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2023. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.    

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel Download Immune 66 (45 MB .mp3, 76 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immunological imprinting (Immunity) COVID-19 vaccine imprinting (bioRxiv) Original antigenic sin (J Inf Dis) Are competition (LJII) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

  In today's episode Marsha will discuss one of the most intricate systems and pathways;the lymphatic system. It is one of the body's most important systems in the human body. The lymphatic system is a host of tissues and organs where the body removes toxins from the body and transport lymph. The lymph is the fluid that contains infection fighting white blood cells throughout the body.   It is important to implement good habits such as diet, exercise as well as practice stress management techniques to keep the body healthy. In this episode we will go over the functions as well as signs of lymphatic fluid back up.    The purpose of this episode is to understand the lymphatic system and use the knowledge to help improve your overall health and wellbeing for a stronger immune system. Prevention is always the best medicine. 

LISTEN ​This week, to celebrate 100 episodes and over 2 years of filming, Dr. Paul and DeeDee Hoover come together to announce how With the Wind is expanding with KidsFirst4Ever.com, an initiative aimed at informing parents on fundamental principles for the growth and development of our children. The show will continue to bring you even more powerful interviews and critical information you can’t get through mainstream sources. Tune in to hear how KidsFirst4Ever can be a lifel [...]

Guests: Dr. Bill Weiss, The Ohio State University and Dr. Corwin Nelson, University of FloridaJoining together for another Journal Club to discuss vitamin D as a lactation influence on dairy cows are dairy leaders and nutritional experts Dr. Bill Weiss and Dr. Corwin Nelson. Dr. Weiss, professor emeritus at The Ohio State University spent nearly 33 years of his career focused on dairy cattle nutrition and has published more than 140 journal articles. He began the conversation, introducing the article “Effect of prepartum source and amount of vitamin D supplementation on lactation performance of dairy cows” and mentioning Mike Piondexter as the first publishing author. 2:20Discussing the research study in depth was Dr. Corwin Nelson, Piondexter's advisor. He began by introducing the Journal of Dairy Science article, highlighting the nutritional effects of supplementing vitamin D and the connection between feeding two different forms. 6:15Dr. Nelson shared studies dating back to 1980 to indicate some vitamin D degradation. But added that most rations have between 30,000 to 50,000 units of vitamin D3 on top of basic international units. 9:40In the article, the abstract shows productive measures such as body weight and condition, dry matter intake and factors. However, Dr. Weiss mentioned the majority of research data derived from cows during their last few weeks of weaning. 13:21Dr. Nelson said that research also analyzed net energy between using colostrum and vitamin D, adding that feeding the 25-hydroxyvitamin D in the ration resulted in higher results of energy. 14:14When looking at energy corrected milk, Dr. Nelson said in about 42 days he's seen interaction between cows producing the most milk and the three milligrams per day of 25-hydroxyvitamin D supplementation. 19:01Anti-inflammatory is another mode of action vitamin D has shown to effectively decrease in cows with lower serum. In fact, three to four weeks is the optimum benefit when it comes to supplementing less than the elevated 25-hydroxyvitamin D recommendation. 32:55It was also mentioned that there may be a possible United States Department of Agriculture (USDA) grant opportunity to look at the long term effects of cow responses, maternal and neonatal vitamin D nutrition and a more focused approach to the immune system are all upcoming research modes of actions. 42:27Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

This week on Lift U Up: Inspiring Health Stories, we're joined by a best-selling mother-daughter duo who's teaching us about Traditional Chinese Medicine (TCM) and making it accessible for all. Healing Herbal Soups authors Rose Cheung and Genevieve Wong used their time in the pandemic for good - writing a cookbook full of healing recipes inspired by and passed down from TCM doctors. In this episode, the pair share their favorite recipes, the impact TCM has had on them and others, and the health benefits you may start to see yourself with some of their tips.

Get ready to go back to the basics with Dr. Jeffrey Bland, the "father of functional medicine," as he guides us through the powerful concept that food is information for our bodies. He challenges us to step out of our comfort zones (literally) and shows us the various branches of the Immune System, including innate, acquired, and lymphocytes.Also, discover how you can rejuvenate your immune system through simple lifestyle choices like diet, stress management, and exercise. And finally, explore the intriguing question of whether we can turn up our immunity too much and trigger autoimmunity. Join us for this refresher episode covering the basics to take control of your health today!Links for this episode:bigboldhealth.compro.bigboldhealth.comUse the discount code: BETTER20 for 20% off (valid through 6/30/23).Study mentioned in the episode:Public health lessons from the mid-Victorian working class dietEpisode Overview (timestamps are approximate): 5:41 - Dr. Bland's history11:35 - Problem(s) with the current medical system14:40 - How to build your plate17:21 - Weakening nutritious food through agriculture24:20 - The diversity of the foods we eat24:49 - Our five different taste types28:40 - The rules about how to eat31:21 - Our tastebuds are programmable35:26 - Immune System 10140:40 - Innate immunity42:55 - Low Stress and Good Food45:29 - How to rejuvenate your immune system48:54 - How to take Himalayan Tartary Buckwheat52:00 - The idea of “Rewilding”54:57 - Can we boost immunity too far? ie. Autoimmunity1:04:10 - Finding your personal dietWe'd like to thank our sponsors:Athletic Greens - redeem an exclusive offer hereFourSigmatic Use code DRSTEPHANIE for 10% offOrion Red Light Therapy - Use the code STEPHANIE10 for 10% offSchinouusa - Use code DR.ESTIMA10 for 10% offBIOOPTIMIZERS - receive 10% off your order with Promo Code "ESTIMA"The DNA  Company - $50 discount using code "DRSTEPHANIE" at checkout.HVMN Ketones - get 10% off your order with Promo Code “STEPHANIE”ILIA BeautyLiving Libations - Use code BETTER for 15% offLMNT Electrolytes - A FREE 7-flavor sample pack!PRIMEADINE - get 10% Off your Order with Promo Code “DRSTEPHANIE10” Follow Me On InstagramWatch Better! on YouTubeGet yourself a copy of my best-selling book, The Betty Body

AABP Executive Director Dr. Fred Gingrich is joined by Dr. Alexis Thompson, the lead author on the paper published in The Bovine Practitioner Vol. 56 No. 2 titled “Failed transfer of passive immunity is a component cause of pre-weaning disease in beef and dairy calves: A systematic review and meta-analysis”. The objective of the paper was to conduct a systematic review and meta-analysis of literature regarding failed transfer of passive immunity (FTPI) and evaluate the strength of association between FTPI and disease in pre-weaned calves. Both dairy, beef and mixed breed cattle papers were included in the study to answer the question “how strongly is FTPI diagnosis associated with the risk of disease in pre-weaned calves”. Thompson walks listeners through the detailed materials and methods section of the paper to describe how the literature search was performed, inclusion and exclusion criteria for the papers evaluated, data extracted from each paper, and setting cut-points for morbidity and mortality. A total of 22 papers were included in the final data set. Thompson also defines the terms used in the paper including risk ratio, attributable fraction, preventable fraction and population attributable fraction. The outcomes evaluated included morbidity, mortality, diarrhea and pneumonia. The results of this meta-analysis indicated that FTPI is a component cause of pre-weaning disease in calves and there was variability between the strength of the association between the papers included in the study. There are many contributing causes of pre-weaning calf disease and the impact of FTPI on a calf or herd's risk of developing disease depends on the presence of other component causes of disease. This is an important consideration when veterinarians are evaluating disease outbreaks in herds to ensure a holistic systems approach to identify all component causes of the outbreak.Registration for the 56th AABP Annual Conference is now open. Gingrich mentions some of the opportunities at the conference to evaluate herd outbreaks and using data to solve problems in cattle practice. For more information and to register for the conference, visit this page. Preconference seminar information can be found at this link and the full schedule is available on this page. Thompson, AC, & Smith, DR (2022). Failed transfer of passive immunity is a component cause of pre-weaning disease in beef and dairy calves: A systematic review and meta-analysis. The Bovine Practitioner, 56(2), 47–61. https://doi.org/10.21423/bovine-vol56no2p47-61  

This week: Eight fake electors get immunity deals in Georgia; DoJ gets rare convictions on seditious conspiracy charges; plus we're not going to call her Liz Holmes. Youtube:  https://www.youtube.com/@Its.Complicated/ Subscribe to our podcast  https://link.chtbl.com/its-complicated Follow Asha on Twitter: https://twitter.com/AshaRangappa_ Asha's Substack: https://asharangappa.substack.com/ Follow Renato on Twitter: https://twitter.com/renato_mariotti Follow Asha on Instagram: https://www.instagram.com/asha.rangappa/ Follow Renato on Instagram: https://www.instagram.com/renato.mariotti/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Today's guest is Dr. Akil Palinahsamy, a Harvard-trained physician who practices integrative medicine, blending his conventional medical expertise with holistic approaches including functional medicine and Ayurveda. “Dr. Akil” attended Harvard University and graduated magna cum laude with a Bachelor of Arts in biochemical sciences. He earned an MD from the University of California, San Francisco (UCSF) and completed family medicine residency training at Stanford University. He then graduated from a fellowship in integrative medicine with Dr. Andrew Weil at the University of Arizona, and received certification in mind-body medicine from the Georgetown University Center. He is the Department Chair for Integrative Medicine at the Sutter Health Institute for Health and Healing (IHH). He also serves as IHH Physician Director for Community Education and leads their educational initiatives and programs. Dr. Akil has been a consultant with the Medical Board of California for many years.    A widely known speaker and educator, he is the author of THE TIGER PROTOCOL and The Paleovedic Diet: A Complete Program to Burn Fat, Increase Energy, and Reverse Disease.  As he has done for over two decades, Dr. Akil sees patients and conducts clinical research studies in the San Francisco Bay Area. In our conversation we discuss: The 5 pillars of his protocol to optimize health and prevent autoimmune issues Those foods that you should eliminate and add in to support your natural detoxification pathways  The powerful antioxidant you should be aware of and how antioxidants work to combat oxidative stress and free radicals in the body Lifestyle factors to incorporate into your daily life today, and how your digestive system can be a great communication tool to signal something might be off The importance of sweating, and what you can do even if you don't swear during exercise.  His two-phase elimination and reintroduction diet that addresses toxins, heals infections, and improves gut health, which anyone can do to optimize their health.   Let's Head to our chat Resources:  Gratisfied Healthified Online Magazine Instagram: @gratisfied @healthified Empower Bar Baking Mix  Use code HEALTHIFIED to save on all Gratisfied products! @doctorakil on Instagram Doctor Akil and his books

Dr. Robert Silverman is a chiropractic doctor, clinical nutritionist, national/international speaker, author of Amazon's #1 bestseller Inside-Out Health, and founder/CEO of Westchester Integrative Health Center. He has a Master of Science degree in human nutrition and five other designations in clinical nutrition. The ACA Sports Council named Dr. Silverman “Sports Chiropractor of the Year” in 2015. With over two decades of clinical experience, Dr. Silverman is a widely respected thought leader in his field. In this episode, we cover: - the biggest health problem in America today - how your immune system is supposed to respond to illnesses - what exactly is a cytokine storm - getting your smell and taste back post-COVID - strategies to overcome long COVID symptoms - how to best support your immune system now and into the future ... and more! Dr. Silverman's 7Rs - which are super similar to what I use with my own clients! Reset your diet and lifestyle. Remove toxins, food allergies, and bad bacteria. Replace stomach acid, digestive enzymes, and good gut bacteria. Regenerate your gut lining with nutrients. Reinoculate your gut with good bacterial strains and prebiotics. Retest to see any changes. Retain good gut health. You can connect with him over on Instagram @drrobertsilverman Learn more about Dr. Silverman's work on his websites: DrRobertSilverman.com and ImmuneReboot.com You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.

Lisa is joined every Wednesday for QUICKFIRE WEDNESDAYS where we discuss articles from www.naturallysavvy.com Lisa and Dr. Forrest discuss the article, Exercise for Boosted Immunity: 8 Outdoor Activities To Start Practicing Right Away.Here is the link to the article:https://naturallysavvy.com/care/exercise-for-boosted-immunity-8-outdoor-activities-to-start-practicing-right-away/

Elizabeth welcomes Dr. Akil Palanisamy, M.D., a Harvard-trained physician who practices integrative medicine, blending his conventional medical expertise with holistic approaches such as ayurvedic medicine. After completing his family medicine residency training at Stanford, Dr. Akil graduated from a fellowship in integrative medicine with the widely known speaker and educator, Dr. Andrew Weil. Dr. Akil authored The Paleovedic Diet and has written a new book, The Tiger Protocol: An Integrative, 5-Step Program to Treat and Heal Your Autoimmunity. During the conversation with Elizabeth, Dr. Akil explains the reasons for the growing prevalence of autoimmune disorders today and describes the research and years of patient care that led to the creation of the 5-step TIGER protocol. Dr. Akil also shares his views on prevention, detoxification, as well as the most effective foods and lifestyle changes to heal the body and achieve optimal health and energy.Mentioned: Find All Season 3 Episodes Here Smiling MindDr. Weil Find our Grain-Free Granolas at Walmart: Here or at a store near you by using our store finder: HereOrder a delicious Smoothie King smoothie bowl topped with our Original Granola: HereSay Hi To Elizabeth and Purely Elizabeth: Website | InstagramDr. Akil Website | The Tiger Protocol

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In this thought-provoking episode, we dive into a variety of pressing topics, including the immunity deals for fake electors in Fulton County, Georgia's Governor Kemp's moves on healthcare, immigration updates, and the potential rise of Gen. Charles Q. Brown. Plus, we discuss our Party Pooper and Party Starter of the week.

Tuesday on Political Rewind: At least eight fake electors have immunity in Georgia's election probe. We'll discuss where Fani Willis' investigation goes from here. Meanwhile, President Biden is meeting with leaders over the debt ceiling. Plus, how the writers' strike is affecting Georgia's film industry. The panel: King Williams, documentarian and journalist, The Atlanta Way, @IamKingWilliams Margaret Coker, editor-in-chief, The Current, @mideastmargaret Shaunya Chavis-Rucker, divisional head, Fulton Films Office at Fulton County Government, @Shaunya_Chavis Tamar Hallerman, senior reporter, The Atlanta Journal-Constitution, @TamarHallerman Timestamps 0:00 - Introduction 3:00 - Eight fake Republican electors have taken immunity deals in Fulton probe. 11:00 - Gov. Brian Kemp signed a district attorney oversight bill. 16:00 - Looking at vetoed bills on scholarships, job training. 20:00 - State Dems call for a special session to address gun violence. 22:00 - The Biden administration looks to avoid a debt ceiling crisis. 29:00 - The head of the CDC has put in her resignation. 33:00 - Breaking down the stateside impact of the writer's strike. Wednesday on Political Rewind: We welcome the AJC's Greg Bluestein to the panel.

LISTEN ​In his From the Heart segment, Dr. Paul talks about the difficult choices we make that often require sacrifice. Navigating these complicated choices will look different for everybody. It’s up to all of us to show love and compassion rather than criticism and judgement, especially to those who might be making choices out of fear. We need to do our best to be a conduit of light to loved ones and others struggling through difficult times. You need to learn to think for [...]

Donna Jackson Nakazawa is an acclaimed science writer who loved to tackle complex problems with big implications for people's everyday life and health. In this interview, she explains one of the biggest and most exciting of these topics: the field of psycho neuroimmunology, of the interplay between our brain, our stress response, and our immune system. Listen to the interview to learn how difficult childhood events shape our stress response for life, why the brain has its own immune system and what this has to do with our body's immune system, why emotional or social threats can have a serious impact on physical health, how early childhood experiences can contribute to autoimmune disease later in life, and much more. Join the conversation at the written version of the article here: https://getwellbe.com/psycho-neuroimmunology-donna-jackson-nakazawa

Welcome to the ASMR Sleep Clinic! In this video, I will be conducting your sleep clinic trials (with your consent of course) to test out 10 ASMR triggers that are designed to make you tingle and fall asleep INSTANTLY (psst...you'll be cured before Level 10). These 10 tingly triggers are: negative energy plucking, fluff muff mic scratching, clipboard and wooden coaster tapping, lid sounds, follow the light, ear cleaning, facial mist spray, face brushing, foam mic scratching, and unintelligible whispers/mouth sounds. I hope you enjoy my butterfly! ✨ASMR Triggers in today's Podcast: 00:00 - check in 02:51 - checking your vitals 08:05 - relaxation candle & breathing exercise 10:15 - quick rundown of the trials 10:44 - Level 1: negative energy plucking 14:25 - Level 2: fluff muff mic scratching 19:30 - Level 3: clipboard & wooden coaster tapping 24:07 - Level 4: lid sounds 28:57 - Level 5: follow the light 32:00 - Level 6: ear cleaning 38:07 - Level 7: facial mist spray 41:20 - Level 8: face brushing 44:56 - Level 9: foam mic scratching 49:05 - Level 10: unintelligible whispers/mouth sounds 55:16 - analysis & results

Eight alleged fake Trump electors in Georgia have accepted immunity deals.Trump's deposition in the defamation lawsuit is made public.Dr. Rochelle Walensky is stepping down as head of the CDC.USA TODAY World Affairs Correspondent Kim Hjelmgaard puts the coronation of King Charles III in context.Courier Journal Breaking News Editor Lucas Aulbach previews the Kentucky Derby.Episode Transcript available hereAlso available at art19.com/shows/5-ThingsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Fake electors for Trump cut a deal in Georgia. So what does this mean for the Fulton County District Attorney's case? Plus, Trump's deposition in the E. Jean Carroll rape case is released. Will he end up taking the stand? Also, the head of Russia's private army is now vowing to pull his fighters from the front lines as he tears into the Kremlin all on the eve of a Ukrainian counteroffensive.To learn more about how CNN protects listener privacy, visit cnn.com/privacy

The United Kingdom has a new monarch but not everyone is celebrating. Russia is taking big hits as a Ukrainian counteroffensive looms. Despite “highly unusual” racehorse deaths the 149th Kentucky Derby will happen later today. At least 8 fraudulent electors in Georgia have been granted immunity in the investigation into former President Donald Trump's attempts to overturn the 2020 election. And a University of California Berkley professor who falsely identified as Native American her  “whole life” issues an apology.To learn more about how CNN protects listener privacy, visit cnn.com/privacy

The news of Texas covered today includes:Our Lone Star story of the day: Travis County's leftist George Soros-picked district attorney, and the county attorney, refuse to prosecute the person charged in House Gallery protest that resulted in it being cleared.The state's media has mostly downplayed what happened but the Center Square reported how bad the transvestite activists behaved.This two systems – one for conservatives and one for the Left – will lead to more civil disorder if not stopped.Our Lone Star story of the day is sponsored by Allied Compliance Services providing the best service in DOT, business and personal drug and alcohol testing since 1995.Democrat Allred's senate campaign against Ted Cruz begins with a stumble.Border news gets worse and worse. Meanwhile Governor Abbott gets credit for showing the hypocrisy of America's leftist “woke” mayors.And, other news of Texas.Listen on the radio, or station stream, at 5pm Central. Click for our radio and streaming affiliates.www.PrattonTexas.com

LISTEN In his From the Heart segment, Dr. Paul returns and opens up with us about his experience caring for his mom during her final days. He recounts her bravery in the face of death, reflecting on her legacy of wisdom and courage that can serve as an inspiration for all of us. One message she left behind is one we can all take to heart: Who you listen to determines what you hear, where you stand determines what you see, and what you do determines who you are.— Dr. Paul's Mom In [...]

“Who is raising children? It's not really parents, it's not teachers, it's not coaches or clergymen. It's Twitter influencers. They're the ones that have the ears and souls of our children.”I sit down with Adam Candeub, professor of law at Michigan State University and a senior fellow at the Center for Renewing America. Candeub served as acting deputy and then acting assistant secretary of the Commerce Department's National Telecommunications and Information Administration (NTIA) during Trump's presidency. He was outspoken in his criticism of what he sees as the abuse and expansion of Section 230 of the Communications Decency Law—a federal provision that grants social media companies protection from liability.“This rather limited protection that sort-of mimicked the telephone, the telegraph, and we've had for hundreds of years and we couldn't really survive without, has morphed into a protection of the platforms for anything they do,” Candeub says.Candeub currently advocates for the “common carrier” approach to social media, and is involved in a number of major First Amendment cases, both at the state and federal level, which will likely shape the future of Big Tech's impact on our society.“We have given power to these agencies—the gobbledygook alphabet soup of security agencies—that are not really accountable to anybody. And like any other agency, they tend to be co-opted by special interests,” says Candeub.

Show Summary: “Cortisol is highly anti-immune support. It can cause cells to shut down and trigger a cell danger response or create inflammation by over-stressing them. This excessive stress on the body leads to so much immune dysfunction, creating the perfect storm for nasty things to thrive.” Have you ever experienced a sudden breakdown in your immune system, leaving you feeling sick and helpless? It's a frustrating and debilitating experience, often made worse by doctors dismissing our symptoms or attributing them to our imagination.But what if we could shed light on the root causes of our immune system's breakdown? What if we could take control of our health and prevent these breakdowns from happening in the first place?In this episode, we'll delve deep into the workings of the immune system and examine the numerous ways in which it can be compromised, leading to extreme immune dysfunction, such as long COVID syndrome, Epstein Barr, and Lyme disease. Most importantly, we'll discuss practical steps you can take to support your immune system and safeguard your health.Strengthen your body's natural defenses. Tune in to Episode 66 of the Gutsy Health Podcast!Exceptional Highlights:Mitochondrial health is critical for mounting an effective immune response.If the body is overwhelmed with stress and cortisol, it can create the perfect environment for illness and immune dysfunction. You need to focus on changing the terrain of your body rather than just targeting specific viruses or infections, and also identify what could potentially be draining your immune system long-term.Show Highlights: 01:00 - Learn how your immune system works through Juanique's mason jar analogy and why it varies from person to person02:32 - What sets apart those with symptoms from those without despite the prevalence of Epstein Barr in 80% of people?07:11 - How depletion of glutathione can put our bodies at risk for autoimmune disease09:15 - Why some individuals develop long COVID syndrome and how it awakens dormant viruses and shatters the immune system10:35 - A rarely talked about virus causing encephalitis, neurological dysfunction, and mood disorders linked to long COVID and Epstein-Barr14:28 - Terrain theory and its impact on a shattered immune system15:09 - Factors potentially causing drains on your immune system for decades17:46 - Why supplements can't replace food in nurturing your microbiome and overall health19:38 -  The connection between cortisol, stress, and brain inflammation – and how to manage it25:44 - How to support your immune system and not let the information overwhelm youImportant Links: Gutsy Health Podcast Instagram - https://www.instagram.com/gutsyhealthpodcast/Gutsy Health Academy - https://www.mygutsyhealth.com/IT'S GIVEAWAY TIME!

Feed Your Wild turns 5! In this special anniversary BTS episode, you'll get an inside look at how I work with the soul or “Deva” of the Feed Your Wild podcast (as part of the larger Deva of my business) and the evolution of this sacred & creative collaboration.  We dive into Feed Your Wild's astrology by looking at their natal chart - so fun! We look at how the energetics and astro influences of FYW impact the podcast from concept to creation, and how consciously working with the Deva and astro insights of YOUR project/business/Work can be life-changing. We also go over the top 5 episodes of all time and have a fun giveaway for you to have a chance to win a complimentary seat in our Overcoming Imposter Syndrome & Reclaim Your Intuitive Gifts Workshop for Practitioners & Healers! Find the Complete Show Notes Here: wildlyrooted.com/podcast   GIVEAWAY How to win a free seat in the Overcoming Imposter Syndrome & Reclaim Your Intuitive Gifts Workshop for Practitioners & Healers!: You can get up to 2 entries by doing 1 or both of the following: Share on social media (Instagram or Facebook) which is YOUR favorite Feed Your Wild podcast episode! Tag @wildlyrooted and @feedyourwildpodcast  Submit a rating and review on Apple podcasts here and share a screenshot by emailing hello@wildlyrooted.com!   Resources:  Apply for the Wildly Intuitive Practitioner Pathway Subscribe to Wild Meanderings: On the (he)Art of Healing :: A minicast for email subscribers only - you won't find these audios or info anywhere else! Overcoming Imposter Syndrome Workshop: Free to Be ALL Of Me!   In The Episode: Feed Your Wild Ep. 000 Intro to Feed Your Wild :: Food for Your Body, Mind, Soul with Venessa Rodriguez Hiro Boga Feed Your Wild x Ep. 228 Taurus Blood Moon: Eclipse Musing + My Rose Chronicles (Solocast) Feed Your Wild x Ep. 198 {SOLO} Top Insights + Lessons From 300+ Akashic Record Readings in 1.5 Years Feed Your Wild x  Ep. 192 {SOLO} Your Gut, Immunity and Sanity :: Hello Virgo Season Feed Your Wild x Ep. 117 How to Create The Life You Desire Sincerely, From The Heart with Tallia Deljou Feed Your Wild x Ep. 204 DECEMBER :: Akashic Soul Nourishment :: The Freedom Paradox Feed Your Wild x Ep. 128 Medical Astrology 101 :: Mapping Individual & Collective Health Trends + Coronavirus Insights With Judith Hill Feed Your Wild x Ep. 145 Water Is Life :: The Ultimate Sacred Water Episode with Isabel Friend    Where To Find Venessa wildlyrooted.com IG - @wildlyrooted   Submit Submit to Your Questions!  Leave a Rating & Review on Apple podcasts   Support the Podcast Your support means the world... If the show has helped, inspired or spoken to you, it would mean the world to me if you show your support through a small financial contribution.  Each FYW episode is a labor of love that takes me about three days to produce... From as little as $1 a month, your support will help to cover the costs associated with producing and hosting the show. I love you. Thank you from the bottom of my heart! To make a monthly contribution, head to the Patreon page here. If you would like to make a one-time contribution, you may use our personal PayPal Link here and offer any dollar amount you'd like - send to @WildlyRooted: https://www.paypal.com/paypalme/wildlyrooted   Thank you as every penny counts toward supporting this work! xo