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“At some point, feeling good wins over old thoughts.” –VJ HamiltonStruggling with autoimmune disease — or uncomfortable symptoms that you've just learned to live with? What if you could reverse your symptoms? I'm so excited to talk with VJ Hamilton, registered nutritionist and a functional medicine practitioner who specializes in autoimmune disease.I was diagnosed with celiac disease fairly late in life. When I was diagnosed, it just made so much sense and explained so many things. It also led to change. And that can be hard to navigate on your own.Perimenopause and menopause symptoms and those of autoimmune diseases — like brain fog, joint aches, and fatigue — can be signs of both. Plus shifts in hormones can certainly trigger changes or unmask hidden inflammation. Testing and treatment can help.We talk about: Autoimmune disease 101 — what we're actually talking aboutTriggers vs. root causes and how to find the root causeHow to advocate for yourself with doctors and what other practitioner you might want to seeSimple changes you can make to improve your healthFocus not on what you have to cut out for food or what exercise you have to do, but what you need and what you likeEating whole foods instead of prepared meals and how to navigate restaurants and special eventsABOUT VJVJ Hamilton is the founder of The Autoimmunity Nutritionist and an expert in autoimmune disease, specialising in skin disorders, chronic fatigue, joint health, and digestive issues for both men and women.As a Registered Nutritionist with a Medical Science degree (BSc) in Biochemistry & Immunology and having completed the full certification programme at the renowned Institute for Functional Medicine, VJ uses evidence-based nutritional therapies to support her clients in transforming their health.LINKShttps://theautoimmunitynutritionist.com/https://www.instagram.com/theautoimmunitynutritionist/ https://www.linkedin.com/in/theautoimmunitynutritionist/ DOABLE CHANGESAt the end of every episode, we share three doable changes, so you can take what you've heard and put it into action. Action is where change happens. But here's the thing: when we have a goal, a wish, a desire bubbling up in us, it can feel really huge. Sometimes we stop ourselves in our tracks based on how huge our desire feels. Change needs action, but it doesn't need huge action. When we focus on the next step, the next Doable Change that we can integrate into our lives, we don't get stuck and we create momentum. Choose one Doable Change that resonates with you today and really play with it. Fit it into your life, your days, make it work for you — then move on to your next Doable Change. Here are Three Doable Changes from this conversation: MAKE A LIST OF THINGS YOU LOVE TO DO. Changing your lifestyle doesn't have to be terrible! Make a list of things you love to do. Ways you like to be active, rest, connect with others. Make a list of things that make you feel good! Plan for more of those things in your life. That might look like swapping dancing for a gym session or eating food that gives you energy or going to bed on time.RESET IDEAS AROUND FOOD. Here are a few ways to try this Doable Change. First, instead of asking, “What do I have to cut out?” think about what foods you can...
Dr. Kelly Makielski and Dr. Jaime Modiano from the University of Minnesota join us on OsteoBites to discuss comparative extracellular vesicle (EV) biomarkers for osteosarcoma risk and prognosis.They are investigating extracellular vesicle (EV) transcriptomic profiles as minimally invasive biomarkers in canine and pediatric osteosarcoma in two ongoing studies. In the Canine Osteosarcoma Early Detection (COED) study, they are sequencing EV RNA from otherwise healthy dogs in breeds at elevated risk of osteosarcoma to identify gene signatures for the early detection and risk assessment of osteosarcoma. In parallel, they are conducting the KIDsCAN study, where we are sequencing EVs from pediatric osteosarcoma patients to identify prognostic signatures that could ultimately guide treatment intensity, aiming to minimize long-term therapy-associated morbidity without negatively impacting survival. Preliminary results from COED will be shared, along with how their comparative approach is helping to guide the KIDsCAN study.Kelly M. Makielski, DVM, DACVIM (SAIM) is an Assistant Professor of Small Animal Internal Medicine at the University of Minnesota College of Veterinary Medicine and Masonic Cancer Center. Her research focuses on extracellular vesicle (EV) biology and comparative oncology, using naturally occurring cancers in dogs to inform human cancer biology and treatment. She is the recipient of an NIH K01 investigating EV–based biomarkers for osteosarcoma prognosis in pediatric osteosarcoma, to guide personalized therapy and reduce treatment-related morbidity.Dr. Jaime Modiano holds the Alvin and June Perlman Endowed Chair of Animal Oncology and is director of the Animal Cancer Care and Research Program of the College of Veterinary Medicine and the Masonic Cancer Center, University of Minnesota. He completed his training through the Veterinary Medical Scientist Training Program (VMD, PhD) at the University of Pennsylvania, and he followed it with a residency in Clinical Pathology at Colorado State University and a post-doctoral fellowship at the National Jewish Center for Immunology and Respiratory Medicine. Before joining the University of Minnesota, he served on the faculties of Texas A&M University and the University of Colorado Health Sciences Center. Dr. Modiano has also worked in the private sector, as founder of several start-up companies, and as Director of Cancer Immunology and Immunotherapy for the Donald Monk Cancer Research Foundation. Through his research, Dr. Modiano seeks to understand how and why cancer happens and to develop strategies for improving the health and well-being of companion animals and humans alike.
Thousands of children may be avoiding peanut allergies thanks to research indicating that early exposure to—rather than avoidance of—the legume is key. Now there's reason to believe this is true for tons of allergens – and that the great “pandemic” of kid food allergies never needed to happen. Guest: Dr. David Hill, attending physician with the Division of Allergy and Immunology at Children's Hospital of Philadelphia, and The Hill Lab. Want more What Next? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther. Learn more about your ad choices. Visit megaphone.fm/adchoices
Thousands of children may be avoiding peanut allergies thanks to research indicating that early exposure to—rather than avoidance of—the legume is key. Now there's reason to believe this is true for tons of allergens – and that the great “pandemic” of kid food allergies never needed to happen. Guest: Dr. David Hill, attending physician with the Division of Allergy and Immunology at Children's Hospital of Philadelphia, and The Hill Lab. Want more What Next? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther. Learn more about your ad choices. Visit megaphone.fm/adchoices
Thousands of children may be avoiding peanut allergies thanks to research indicating that early exposure to—rather than avoidance of—the legume is key. Now there's reason to believe this is true for tons of allergens – and that the great “pandemic” of kid food allergies never needed to happen. Guest: Dr. David Hill, attending physician with the Division of Allergy and Immunology at Children's Hospital of Philadelphia, and The Hill Lab. Want more What Next? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther. Learn more about your ad choices. Visit megaphone.fm/adchoices
In today's episode, we had the pleasure of speaking with Eunice Wang, MD, about the secondary AML treatment paradigm. Dr Wang is a professor of oncology, leader of the Leukemia Clinical Disease Team, chief of leukemia in the Department of Medicine, and an assistant member of the Tumor Immunology Program in the Department of Immunology at Roswell Park Comprehensive Cancer Center in Buffalo, New York; as well as an associate professor in the Department of Medicine and an academic scholar at the Jacobs School of Medicine and Biomedical Sciences at the State University of New York at Buffalo. In our exclusive interview, Dr Wang discussed the prevalence of secondary AML, and explained that this population lacks standard therapies, often relying on allogeneic stem cell transplantation. She noted that CPX-351, a liposomal formulation of cytarabine and daunorubicin, has generated improved outcomes compared with 7+3 chemotherapy in this population. She also highlighted future research, which includes targeted therapies and less intensive regimens.
In this episode of SHE MD Podcast, Dr. Thaïs Aliabadi and Mary Alice Haney sit down with Dr. Tania Elliott to discuss allergies, immune health, and how hormonal changes impact symptoms. They explore practical strategies to reduce allergy triggers at home, boost immune health naturally, and adopt a personalized approach to allergy care. Dr. Elliott shares insights on seasonal allergies, food allergies, and hidden allergens in daily life, while providing actionable guidance for women navigating hormonal shifts during pregnancy, menopause, or with birth control. Listen to gain evidence-based tips to improve overall health, enhance quality of life, and take control of their wellness journey. Subscribe to SHE MD Podcast for expert tips on PCOS, Endometriosis, fertility, and hormonal balance. Share with friends and visit SHE MD Podcast and Ovii for research-backed resources, holistic health strategies, and expert guidance on women's health and well-being.Sponsors:Saje: Visit Saje.com to purchase plant powered products to remedy your needs. Use Code ‘SHEMD' for 20% off sitewide and free shippingOpill: Opill is birth control in your control, and you can use code SHEMD for twenty five percent off your first month of Opill at Opill.com.iRestore: For a limited time, get a HUGE discount on the iRESTORE Elite + Illumina Face Mask Bundle with code SHEMD at iRestore.comMerit: It's time to simplify your morning (Alt: Ready to simplify your routine?). Head to meritbeauty.com and get their Signature Makeup Bag free with your first order.Peloton: Let yourself run, lift, sculpt, push, and go. Explore the new Peloton Cross Training Tread+ at onepeloton.comGetJoy: As a listener of SheMD, you'll get 50% off your first subscription order of Get Joy's Freeze Dried Raw Dog Food plus two exclusive gifts: a free scoop and a 4oz bag of treats. Shop getjoyfood.com/shemd to support your dog's gut health and overall wellnessProlon: For a limited time, you can be first in line to experience the new Next Gen at special savings. Prolon is offering SHE MD listeners 15% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program!Cymbiotika: Go to Cymbiotika.com/Shemd for 20% off plus free shippingWhat You'll LearnUnderstanding how seasonal allergies, food allergies, and intolerances differHow hormonal changes impact allergy symptoms in womenStrategies to reduce allergy triggers at home and boost immune health naturallyWhen to use at-home allergy tests safely versus consulting a professionalKey Timestamps(02:42) Dr. Tania Elliott's Introduction (05:23) Dr. Elliott's journey in allergy and immunology(08:45) Common myths about allergies and immune health(13:10) Actionable tips: reducing triggers, hormonal considerations, lifestyle adjustments(22:24) Understanding seasonal vs. food allergies and intolerances(28:05) Hormonal shifts affecting immune system and allergies in women(35:58) Microplastics and toxins(49:29) Top 3 lifestyle changes to reduce allergens and improve healthKey Takeaways Seasonal allergies, food allergies, and intolerances affect women differently, especially during hormonal changesHidden allergens in everyday life can trigger reactions without noticeLifestyle factors like sleep, stress, and gut health influence immune resiliencePersonalized allergy care is more effective than one-size-fits-all approachesAt-home allergy tests can be helpful but professional guidance is essential for accurate diagnosisGuest BioDr. Tania Elliott is a dual board-certified physician specializing in Internal Medicine and Allergy/Immunology. She serves as a Clinical Instructor at NYU Langone Health and is a spokesperson for the American College of Allergy, Asthma, and Immunology. Dr. Elliott empowers people to take control of their health through actionable advice and personalized care. She is also the founder of Modern Medical, a consulting firm providing strategic support across healthcare sectors.Links:
Professor Matteo Iannacone is Director of the Division of Immunology, Transplantation and Infectious Diseases, Professor of Pathology, and Head of the Dynamics of Immune Responses laboratory at Vita-Salute San Raffaele University. His work centers on understanding the generation of dysfunctional adaptive immune cells in chronic hepatitis B virus infection and developing new strategies to reprogram them into functional cells endowed with potent antiviral activity.
In the world of social media memes, madness and mayhem, the claim "I've done my research" is usually a euphemism for the far more accurate "I read, heard or watched something on the internet." In this TYP instalment, Professor Bill and I chat about the recent media hysteria around an alleged link between Tylenol (paracetamol in Australia) and autism. And while l'm no expert, it's fair to say that the bloke who's both a Professor of Pharmacology and Toxicology and a Professor of Microbiology and Immunology at Indiana University School of Medicine (The Prof.) is more medically informed and qualified to comment than most. So he did. And I listened. Enjoy.See omnystudio.com/listener for privacy information.
Bioengineer Michael Fischbach studies alternative vaccine delivery methods, like self-administered creams with no needles, health professionals, or side effects. He teases a day when vaccines that don't make you feel bad come in the mail in ketchup-style packets. Such innovations would greatly improve vaccine uptake, especially in developing countries, and speed global response to novel viruses. It would change how we think about vaccines, Fischbach tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Michael FischbachConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Michael Fischbach, a professor of bioengineering at Stanford University.(00:04:24) Cream-Based VaccinesThe discovery that revealed the skin's ability to spark systemic immunity.(00:07:36) Engineering ImmunityModifying staph epidermidis to carry antigens and test immune response.(00:09:38) Tumor RegressionHow engineered bacteria triggered tumor-killing immunity in mice.(00:12:53) Antibody DiscoveryEvidence that skin exposure can generate long-lasting antibodies.(00:17:02) Antibody Response in HumansWhether humans show antibody responses to their own skin bacteria.(00:18:42) Turning Bacteria into VaccinesEmbedding harmless pathogen fragments into bacterial surface proteins.(00:20:55) Immunity Without ShotsHow mice achieved vaccine-level immunity through topical application.(00:24:00) Reimagining Vaccine DeliveryThe potential for self-applied, needle-free, and multiplexed vaccines.(00:26:50) Mechanism Behind Skin ImmunityHow skin immune cells may constantly sample microbes for defence.(00:28:14) Next Steps in DevelopmentThe path toward testing safety, dosage, and delivery in higher models.(00:29:57) Choosing Vaccine TargetsViruses and diseases that could be targets for early skin-based vaccines.(00:31:11) Safety and ReversibilityEnsuring safety with reversible bacteria and limited trial participants.(00:33:04) Transitioning to BiotechTransitioning research from Stanford to large-scale biotech development.(00:34:31) Future In a MinuteRapidfire Q&A: creative science, vaccine innovation, and biology's future.(00:36:56) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Nuclear fusion is the process by which two or more light atomic nuclei combine to form a heavier nucleus, releasing a huge amount of energy in the process. It happens naturally in stars under extreme pressure and temperature. Scientists are trying to bottle that same process inside special machines (like tokamaks or stellarators). That's why people call fusion “making a star in a bottle:. All to chat with Luke O'Neill Professor of Immunology at Trinity College Dublin.
We end the futile struggle, embrace the toxins, and become one with our mould brethren.The full episode is available to Patreon subscribers (2 hours, 38 minutes).Join us at: https://www.patreon.com/DecodingTheGurusSupplementary Material 3800:00 Intro02:54 Boomer Matt reacts to Twitter videos07:31 Shellenberger and Tucker discuss the 9/11 Files12:42 Eric's Google Ngram Investigations17:08 Vindication on the Elephant Graveyard22:00 Eric's ARC lecture goes viral25:24 Andrew Huberman is NOT a phrenologist...29:06 Eric Weinstein vs. Piers Morgan33:44 Everyone knows Eric is a serious thinker46:09 Peterson is taken out of the Gurusphere by Demons and Toxic Mould52:09 Gurus and Bespoke Alternative Health57:00 Social Contagion Hypocrisy01:02:55 Toxic Mould Symbiosis?01:04:46 Pewdiepie, Diogenes, and the Seeker Mindset01:16:14 The Wisdom of the Ancients01:21:01 The Meaning Crisis and Christian Pivots01:22:29 Konstantin Kisin's surprising Christian pivot01:25:17 The best person Konstantin ever met (not Francis)01:30:22 The Fifth Column Agrees with Megyn Kelly 88% of the time01:33:07 Megyn Kelly explains how the Democrats crossed the line and must pay01:41:35 Intellectual Clerics for MAGA01:43:16 Slightly Adversarial libertarians for hire01:47:00 Drew Pavlou and Fluid Populism01:50:17 Two Varieties of Online Derangement: Noah Smith's Hot Takes01:53:57 Need for Attention = Desire for Virality01:57:23 Status Seeking Networkers vs Paul Bloom02:01:27 Reflecting on the Al Murray Interview02:02:22 The struggle of podcasters02:04:52 Paul Bloom: The best person in the world?02:06:00 Mike Israetel's Thesis Controversy02:10:30 What does a PhD mean?02:16:55 David Deutsch visits Curt Jaimungal02:22:32 The Dangers of Doubling Down: Pirate Software02:23:32 Hasan Piker and Shock Collar-gate02:27:15 Matt's Take on Shock Collars02:33:51 Dystopia Update: Putin wants Trump to win the Nobel Prize02:37:11 OutroSourcesShellenberger and Tucker discuss the CIA's role in 9/11Grok pressing Eric to get specificThe Elephant GraveyardViral post about Eric's ARC speech on scienceHuberman's phrenology endorsementJordan Peterson's Health Update from MikhailaChris Williamson: It's time to talk about my health.Chang, C., & Gershwin, M. E. (2019). The myth of mycotoxins and mold injury. Clinical Reviews in Allergy & Immunology, 57(3), 449–455.Borchers, A. T., Chang, C., & Eric Gershwin, M. (2017). Mold and human health: A reality check. Clinical Reviews in Allergy & Immunology, 52(3), 305–322.
Cindy sits down with Bali Pulendran at the AAI 2025 meeting where he told the story of how a childhood fascination with the cosmos grew into a career addressing fundamental questions about the human immune response, and how when an antigen enters the body it is like the big bang in how it initiates immune responses. Host: Cindy Leifer Guest: Bali Pulendran Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Systems vaccinology determines antibody responses and durability (Nature 2025) World's largest immunology experiment (Sem Immunol 2024) Systems Vaccinology Review (Immunity 2010) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
“Don't just rely on the textbook definition of when the pollen seasons are. You need to have reliable data to know when the pollen seasons are starting, when they're ending, and when they're peaking.” Dawn JurgensAllergy season may be winding down, but for allergists, the work never really stops. This is the moment between ragweed and winter — a brief respite before the cycle begins again. On this episode, Dr. Mariam Hanna is joined by Dawn Jurgens, Director of Operations and Quality Management at Aerobiology Research Laboratories. She breaks down the science behind pollen and spore counts, why forecasts matter, and how shifting seasons are changing the game for patients and clinicians alike.Timothy grass is the most common and potent trigger globally, while birch remains the most clinically relevant pollen in Canada. Pine releases large amounts of pollen but isn't highly allergenic.Pollution and thunderstorms can make pollen more potent by breaking it apart and exposing allergenic epitopes, intensifying symptoms.Cross-reactivity stems from conserved epitopes, meaning patients sensitized to one pollen may react to related species — or even certain foods.Mold spores, especially Alternaria, Cladosporium, and Basidiospores, can mimic ragweed season and are major fall culprits.Canada's pollen seasons are starting earlier than they did 30 years ago, though the fall season hasn't yet extended.Simple strategies — like showering before bed, keeping windows closed, using filters, brushing pets outside, and checking reliable forecasts — can meaningfully reduce exposure.Pollen season may be taking a break, but planning for the next wave starts now.Visit the Canadian Society of Allergy and Clinical ImmunologyFind an allergist using our helpful toolFind Dr. Hanna on X, previously Twitter, @PedsAllergyDoc or CSACI @CSACI_caThe Allergist is produced for CSACI by PodCraft Productions
A Conversation in Veterinary Pathology - The A.C.V.P. Podcast
Today on the podcast, we're excited to welcome Dr. Melissa Macías-Rioseco, a veterinary pathologist whose expertise spans infectious disease, livestock health, and reproductive pathology. Dr. Macías-Rioseco serves as an Associate Professor at UC Davis's California Animal Health & Food Safety Laboratory within the Department of Pathology, Microbiology, and Immunology. What drives someone to give back so generously to their profession and community? In this episode, we explore Dr. Macías-Rioseco's journey—her passion for pathology, her leadership, and her volunteer service with organizations like the ACVP, the Davis-Thompson Foundation (DTF), Latin Comparative Pathology Group (LCPG), and the American Association of Veterinary Laboratory Diagnosticians (AAVLD). Join us for an inspiring conversation about the intersection of science, service, and the joy of sharing knowledge. Links 2025 ACVP Annual Meeting in NOLA Latinx and Hispanic Heritage Month ____ ACVP Social Media Facebook - ACVP Meetings and Topics Instagram - americancollegevetpath X (Twitter) - @ACVP LinkedIn - AMERICAN COLLEGE OF VETERINARY PATHOLOGISTS ____ Thank you to Nicholas Pankow, Assistant Audio Editor, for his help editing this episode. Music: Guestlist by Podington Bear, licensed under an Attribution-NonCommercial 3.0 International License. The contents of this audio do not necessarily reflect the opinions of the American College of Veterinary Pathologists (ACVP) or the participants' affiliations. Spoken audio content and associated photos are the property of the American College of Veterinary Pathologists, 2025.
AI is transforming medicine at a speed never seen before. In this episode, you'll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he's a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension. Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today's standards. You'll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life. You'll Learn: • How digital twins will end human drug testing • Why AGI could replace doctors and computer jobs within five years • How AI models immune function, metabolism, and aging • The role of mitochondria and inflammation in longevity • How GLP-1 drugs and metformin extend lifespan • What continuous biological monitoring means for health tracking • How AI is transforming functional medicine and personalized care • Why NAD and energy metabolism are key to human performance They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You'll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan. This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation. This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You'll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, Metabolism, AGI, Clinical trials, Human performance, Aging research, Systems biology, Immunology, Smarter Not Harder Thank you to our sponsors! BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order Resources: • Keep up with Derya's work: https://x.com/derya_?lang=en • Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 — Trailer 01:25 — Intro 02:26 — AI's Role in Extending Lifespan 02:56 — Regulatory Frameworks and Medical Adoption 05:19 — Problems with the Immune System 08:19 — Chronic Fatigue and Long COVID Research 10:32 — Modern Testing and Multi-Omic Analysis 14:07 — Personal Longevity Strategy and Supplements 15:17 — Understanding Exhausted Cells 23:43 — Personalization in Medicine and AI Analysis 31:35 — Longevity Escape Velocity 36:13 — AI Doctors and Prescriptions 39:55 — Data Quality Concerns in AI Training 43:19 — The Future of Wearable Technology 45:50 — Revolutionizing Education with AI 49:04 — The Future of Higher Education 52:03 — Future of Work and AI Agents See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
2025 Nobel Prize for Medicine or Physiology goes to immunology for the discovery of a key controller of the immune system that stops autoimmune diseases. American scientists Mary Brunkow and Fred Ramsdell and Shimon Sakaguchi from Japan won the 2025 Nobel Prize in Physiology or Medicine on Monday for work shedding light on how the immune system spares healthy cells, creating openings for possible new autoimmune disease and cancer treatments. Luke O'Neill, Professor of Immunology at Trinity College Dublin brings us the details.
In this inspiring episode, Dr. Felipe Gálvez-Cancino, group leader at Oxford's Center for Immuno-Oncology, walks us through his team's groundbreaking research on macrophages, T cells, and immune regulation in solid tumors. Tracing his path from early cancer vaccine work to advanced antibody-dependent cellular phagocytosis (ADCP), Felipe shares how his team is working to reprogram tumor-associated macrophages to more efficiently eliminate cancer cells.He explains how regulatory CD4+ T cells suppress both T cell and macrophage responses within tumors and how removing that suppression can supercharge phagocytic function. We also hear how his lab is leveraging mouse models of hepatocellular carcinoma, clinical samples, and modern molecular biology techniques (like in vivo liver transfection and CRISPR-ready plasmid engineering) to study intratumor heterogeneity and antigen spreading.Felipe also reflects on the value of early molecular biology training—like mastering gigapreps—and emphasizes the importance of curiosity, persistence, and collaboration in scientific careers. Whether you're interested in cancer biology, immunotherapy, or just passionate about translating discoveries into new therapies, this episode offers both technical depth and motivational insight. Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague. Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.
The Nobel Prize in physiology or medicine was awarded to three scientists for their work in immunology. Daniel Griffin, MD, PhD, Chief of Infectious Disease for Island Infectious Diseases, the largest physician-owned Infectious Disease Specialist Group on Long Island, an infectious disease specialist and clinical instructor of medicine at Columbia University and president of Parasites Without Borders and co-host of the podcast "This Week in Virology", explains their breakthrough and what it means for future treatments for autoimmune diseases, cancer, and more.
Elizabeth Marnik, also known as Science Whiz Liz, grew up unvaccinated, yet she is now an immunologist, science communicator, and advocate for vaccines–this is her story. Host: Cindy Leifer Guest: Elizabeth Marnick Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server More about Liz on her webpage ScienceWhizLiz on Instagram From the Science Classroom with Science Whiz Liz on Substack Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
mRNA vaccines are not supposed to contain DNA. But Dr. Jessica Rose says a new study tested “32 vials of Pfizer and Moderna COVID products that included 16 unique lots… We did not only find DNA, we found it in ALL lots tested and most importantly, the DNA levels were all above pre-designated EMA thresholds of 10 ng/dose.” “We measured the amount of DNA in the vials using 2 methods… (qPCR and fluorometry),” she continues. “It was submitted as evidence on the congressional record by the honorable Senator Ron Johnson.” JP Sears is a comedian, author, and YouTuber known for his satirical take on politics, fitness, and faith. He hosts Awaken with JP on Rumble and YouTube. Follow at https://x.com/AwakenWithJP Dr. Jessica Rose is a Canadian researcher with a Bachelor's in Applied Mathematics and a Master's in Immunology from Memorial University of Newfoundland. She holds a PhD in Computational Biology from Bar Ilan University and completed postdoctoral research in Molecular Biology and Biochemistry. Find her at https://jessicasuniverse.com and follow at https://x.com/JesslovesMJK 「 SUPPORT OUR SPONSORS 」 Find out more about the brands that make this show possible and get special discounts on Dr. Drew's favorite products at https://drdrew.com/sponsors • FATTY15 – The future of essential fatty acids is here! Strengthen your cells against age-related breakdown with Fatty15. Get 15% off a 90-day Starter Kit Subscription at https://drdrew.com/fatty15 • PALEOVALLEY - "Paleovalley has a wide variety of extraordinary products that are both healthful and delicious,” says Dr. Drew. "I am a huge fan of this brand and know you'll love it too!” Get 15% off your first order at https://drdrew.com/paleovalley • VSHREDMD – Formulated by Dr. Drew: The Science of Cellular Health + World-Class Training Programs, Premium Content, and 1-1 Training with Certified V Shred Coaches! More at https://drdrew.com/vshredmd • THE WELLNESS COMPANY - Counteract harmful spike proteins with TWC's Signature Series Spike Support Formula containing nattokinase and selenium. Learn more about TWC's supplements at https://twc.health/drew 「 MEDICAL NOTE 」 Portions of this program may examine countervailing views on important medical issues. Always consult your physician before making any decisions about your health. 「 ABOUT THE SHOW 」 Ask Dr. Drew is produced by Kaleb Nation (https://kalebnation.com) and Susan Pinsky (https://twitter.com/firstladyoflove). This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. Learn more about your ad choices. Visit megaphone.fm/adchoices
Could the secret to fertility and hormone balance be found in mushrooms?
John Maytham speaks to Professor Elizabeth Mayne, a leading immunologist and Head of the Division of Immunology at the University of Cape Town to discuss the Nobel peace prize going to the brain breakthrough trio and what this discoveries means for the medical field in South Africa Presenter John Maytham is an actor and author-turned-talk radio veteran and seasoned journalist. His show serves a round-up of local and international news coupled with the latest in business, sport, traffic and weather. The host’s eclectic interests mean the program often surprises the audience with intriguing book reviews and inspiring interviews profiling artists. A daily highlight is Rapid Fire, just after 5:30pm. CapeTalk fans call in, to stump the presenter with their general knowledge questions. Another firm favourite is the humorous Thursday crossing with award-winning journalist Rebecca Davis, called “Plan B”. Thank you for listening to a podcast from Afternoon Drive with John Maytham Listen live on Primedia+ weekdays from 15:00 and 18:00 (SA Time) to Afternoon Drive with John Maytham broadcast on CapeTalk https://buff.ly/NnFM3Nk For more from the show go to https://buff.ly/BSFy4Cn or find all the catch-up podcasts here https://buff.ly/n8nWt4x Subscribe to the CapeTalk Daily and Weekly Newsletters https://buff.ly/sbvVZD5 Follow us on social media: CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.
Immune discusses the potential future of delivering vaccines by flossing your teeth and how antibodies in human milk shape the normal immune responses in newborns. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Floss-based vaccination (Nat Biomed Engineering 2025) Press article on Floss-based vaccine paper (Sci News) Human milk IgA promotes immune development (PNAS 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
How do you hold on to hope while still being realistic about the work that needs to be done? Immunology researcher David Fajgenbaum and public health expert Celina de Sola discuss how they scaled personal missions into organizations making long-term impact on communities near and far. They explore how to stay motivated, discover your leadership style and uncover overlooked solutions hiding in plain sight. (This conversation is part of "TED Intersections," a series featuring thought-provoking conversations between experts navigating the ideas shaping our world.)Interested in learning more about upcoming TED events? Follow these links:TEDNext: ted.com/futureyouTEDAI Vienna: ted.com/ai-viennaTEDAI San Francisco: ted.com/ai-sf Hosted on Acast. See acast.com/privacy for more information.
REFERENCES Autoimmun. 2012 Mar 28;38(4):344–353The Journal of Immunology, 2009. Volume 182, Issue Supplement_1, AprIL. Page 99.1, Trends in Immunology 2025. ReviewVolume 46, Issue 4p324-337AprilCytokine. 2024 Feb 15;176:156540. Proc Natl Acad Sci U S A. 2013 Jun 10;110(26):10652–10657J Cell Sci. 2019 Sep 16;132(18):jcs213124.Cellular & Molecular Immunology 2025. volume 22, pages134–149 Plant/Page.1971. Battle of Evermore on LZIV.https://music.youtube.com/watch?v=88b0OYxdtyM&si=axHZuES3K2lftqDTWinwood, S.1969. Had to Cry Today. Blind Faith.https://music.youtube.com/watch?v=Z4Yo_VbGdMg&si=Pq0OXwT0lW2pUmT8Mozart, WA. 1781. Idomeneo Overture K 366.https://music.youtube.com/watch?v=OAXn_rs17m4&si=nFI7jghahXFS7NhT
Is that penicillin or amoxicillin allergy real? Probably not. In this episode, we explore how to assess risk, talk to parents, and refer for delabeling. You'll also learn what happens in the allergy clinic, why the label matters, and how to be a better antimicrobial steward. Learning Objectives Describe the mechanisms and clinical manifestations of immediate and delayed hypersensitivity reactions to penicillin, including diagnostic criteria and risk stratification tools such as the PEN-FAST score. Differentiate between low-, moderate-, and high-risk penicillin allergy histories in pediatric patients and identify appropriate candidates for direct oral challenge or allergy referral based on current evidence and guidelines. Formulate an evidence-based approach for evaluating and counseling families in the Emergency Department about reported penicillin allergies, including when to recommend outpatient referral for formal delabeling. Connect with Brad Sobolewski PEMBlog: PEMBlog.com Blue Sky: @bradsobo X (Twitter): @PEMTweets Instagram: Brad Sobolewski References Khan DA, Banerji A, Blumenthal KG, et al. Drug Allergy: A 2022 Practice Parameter Update. J Allergy Clin Immunol. 2022;150(6):1333-1393. doi:10.1016/j.jaci.2022.08.028 Moral L, Toral T, Muñoz C, et al. Direct Oral Challenge for Immediate and Non-Immediate Beta-Lactam Allergy in Children. Pediatr Allergy Immunol. 2024;35(3):e14096. doi:10.1111/pai.14096 Castells M, Khan DA, Phillips EJ. Penicillin Allergy. N Engl J Med. 2019;381(24):2338-2351. doi:10.1056/NEJMra1807761 Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review.JAMA. 2019;321(2):188–199. doi:10.1001/jama.2018.19283 Transcript Note: This transcript was partially completed with the use of the Descript AI and the Chat GPT 5 AI Welcome to PEM Currents, the Pediatric Emergency Medicine podcast. As always, I'm your host, Brad Sobolewski, and today we are taking on a label that's misleading, persistent. Far too common penicillin allergy, it's often based on incomplete or inaccurate information, and it may end up limiting safe and effective treatment, especially for the kids that we see in the emergency department. I think you've all seen a patient where you're like. I don't think this kid's really allergic to amoxicillin, but what do you do about it? In this episode, we're gonna break down the evidence, walk through what actually happens during de labeling and dedicated allergy clinics. Highlight some validated tools like the pen FAST score, which I'd never heard of before. Preparing for this episode and discuss the current and future role of ED based penicillin allergy testing. Okay, so about 10% of patients carry a penicillin allergy label, but more than 90% are not truly allergic. And this label can be really problematic in kids. It limits first line treatment choices like amoxicillin, otitis media, or penicillin for strep throat, and instead. Kids get prescribed second line agents that are less effective, broader spectrum, maybe more toxic or poorly tolerated and associated with a higher risk of antimicrobial resistance. So it's not just an EMR checkbox, it's a label with some real clinical consequences. And it's one, we have a role in removing. And so let's understand what allergy really means. And most patients with a reported penicillin allergy, especially kids, aren't true allergies in the immunologic sense. Common misinterpretations include a delayed rash, a maculopapular, or viral exum, or benign, delayed hypersensitivity, side effects, nausea, vomiting, and diarrhea. And unverified childhood reactions that are undocumented and nonspecific. Most of these are not true allergies. Only a very small subset of patients actually have IgE mediated hypersensitivity, such as urticaria, angioedema, wheezing, and anaphylaxis. These are super rare, and even then they may resolve over time without treatment. If a parent or sibling has a history of a penicillin allergy, remember that patient might actually not be allergic, and that is certainly not a reason to label a child as allergic just because one of their first degree relatives has an allergy. So right now, in 2025, as I'm recording this episode, there are clinics like the Pats Clinic or the Penicillin Allergy Testing Services at Cincinnati Children's and in a lot of our peer institutions that are at the forefront of modern de labeling. Their approach reflects the standard of care as outlined by the. Quad ai or the American Academy of Allergy, asthma and Immunology and supported by large trials like Palace. And you know, you have a great trial if you have a great acronym. So here's what happens step by step. So first you stratify the risk. How likely is this to be a true allergy? And that's where a tool like the pen fast comes. And so pen fast scores, a decision rule developed to help assess the likelihood of a true penicillin allergy based on the patient's history. The pen in pen fast is whether or not the patient has a self-reported history of penicillin allergy. They get two points if the reaction occurred in the past five years. Two points if the reaction is anaphylaxis or angioedema. One point if the reaction required treatment, and one point if the reaction was not due to testing. And so you can get a total score of. Up to six points. If you have a score of less than three. This is a low risk patient and they can be eligible for direct oral challenge. A score greater than three means they're higher risk and they may require skin testing. First validation studies show that the PEN FFA score of less than three had a negative predictive value of 96.3%. Meaning a very, very low chance of a true allergy. And this tool has been studied more extensively in adults, but pediatric specific adaptations are emerging, and they do inform current allergy clinic protocols. But I would not use this score in the emergency department just to give a kid a dose of amoxicillin. So. For low risk patients, a pen fast score of less than three or equivalent clinical judgment clinics proceed with direct oral challenge with no skin testing required. The protocol is they administer one dose of oral amoxicillin and they observe for 62 120 minutes monitoring for signs of reaction Urticaria. Respiratory symptoms or GI upset. This approach is safe and effective. There was a trial called Palace back in 2022, which validated this in over 300 children. In adolescents. There were no serious events that occurred. De labeling was successful in greater than 95% of patients. And skin tested added no benefit in low risk patients. So if the child tolerates this dose, then you can remove that allergy immediately from the chart. Parents and primary care doctors will receive a summary letter noting that the challenge was successful and that there's new guidance. Children and families are told they can safely receive all penicillins going forward. And providers are encouraged to document this clearly in the allergy section of the EMR. So you're wondering, can we actually do this in the emergency department? Technically, yes, you can do what you want, but practically we're not quite there yet. So we'd need clearer risk stratification tools like the Pen fast, a safe place for monitoring, post challenge, clinical pathways and documentation support. You know, a clear way to update EMR allergy labels across the board and involvement or allergy or infectious disease oversight. But it's pretty enticing, right? See a kid you diagnose otitis media. You think that their penicillin allergy is wrong, you just give 'em a dose of amox and watch 'em for an hour. That seems like a pretty cool thing that we might be able to do. So some centers, especially in Canada and Australia, do have some protocols for ED or inpatient based de labeling, but they rely on that structured implementation. So until then, our role in the pediatric emergency department is to identify low risk patients, avoid over document. Unconfirmed reactions and refer to allergy ideally to a clinic like the pets. So who should be referred and good candidates Include a child with a rash only, especially one that's remote over a year ago. Isolated GI symptoms. Parents unsure of the details at all. No history of anaphylaxis wheezing her hives, and no recent serious cutaneous reactions. I would avoid referring and presume that this allergy is true. If they've had recent anaphylaxis, they've had something like Stevens Johnson syndrome dress, or toxic epidermolysis necrosis. Fortunately, those are very, very rare with penicillins and there's a need for penicillin during the ED visit without allergy backup. So even though we don't have an ED based protocol yet. De labeling amoxicillin or penicillin allergy can start with good questions in the emergency department. So here's one way to talk to patients and families. You can say, thanks for letting me know about the amoxicillin allergy. Can I ask you a few questions to better understand what happened? This is gonna help us decide the safest and most effective treatment for your child today, and then possibly go through a process to remove a label for this allergy that might not be accurate. You wanna ask good, open-ended questions. What exactly happened when your child took penicillin or amoxicillin? You know, look for rash, hives, swelling, trouble breathing, or anaphylaxis. Many families just say, allergic, when the reaction was just GI upset, diarrhea or vomiting, which is not an allergy. How old was your child when this happened? Reactions that occurred before age of three are more likely to be falsely attributed. How soon after taking the medicine did the reaction start? Less than one hour is an immediate reaction, but one hour to days later is delayed. Usually mild and probably not a true allergy. Did they have a fever, cold or virus at that time? Viral rashes are often misattributed to antibiotics, and we shouldn't be treating viruses with antibiotics anyway, so get good at looking at ears and know what you're seeing. And have they taken similar antibiotics since then? Like. Different penicillins, Augmentin, or cephalexin. So if they said that they were allergic to amoxicillin, but then somehow tolerated Augmentin. They're not allergic. If a patient had rash only, but no hive swelling or difficulty breathing, no reaction within the first hour. It occurred more than five years ago or before the kid was three. And especially if they tolerated beta-lactam antibiotics. Since then, they're a great candidate for de labeling and I would refer that kid to the allergy clinic. Generally, they can get them in pretty darn quick. Alright, we're gonna wrap up this episode. Most kids labeled penicillin allergic or amoxicillin allergic, or not actually allergic to the medication. There are some scores like pen fasts that are validated tools to assess risk and support de labeling. Direct oral challenge for most patients is safe, efficient, and increasingly the standard of care. There are allergy clinics like the Pats at Cincinnati Children's that can dela children in a single visit with oral challenges alone, needing no skin testing, and emergency departments can play a key role in identifying and referring these patients and possibly de labeling ourselves in the future. Well, that's all for this episode on Penicillin Allergy. I hope you learn something new, especially how to assess whether an allergy label is real, how to ask the right questions and when to refer to an allergy testing clinic. If you have feedback, send it my way. Email, comment on the blog, a message on social media. I always appreciate hearing from you all, and if you like this episode, please leave a review on your favorite podcast app. Really helps more people find the show and that's great 'cause I like to teach people stuff. Thanks for listening for PEM Currents, the Pediatric Emergency Medicine podcast. This has been Brad Sobolewski. See you next time.
Dr. Hafeez Diwan: The Power of 'Meh', Writing Passions, and Handling Obnoxious PeopleIn this episode of The Girl Doc Survival Guide, Dr. Hafeez Diwan, Professor of Pathology, Immunology, and Dermatology at Baylor College of Medicine, shares insights on his diverse writing endeavors, from self-help books to a young adult sci-fi fantasy novel co-authored with his daughter. Highlighting ideas from his books 'The Power of Meh' and 'How to Love Obnoxious People,' Dr. Diwan discusses strategies for managing emotions, overcoming willpower challenges, and promoting mindfulness. He also reflects on his medical journey and the interplay between his writing and his medical practice.00:00 Introduction to Dr. Hafeez Diwan00:58 Anecdote from Residency02:50 The Writing Journey Begins05:18 The Power of Meh07:26 Loving Obnoxious People11:12 Mastering Willpower14:40 Final Thoughts and Advice
ReferencesCell Mol Life Sci. 2022 Jul 12;79(8):419.J Autoimmun. 2012 Mar 28;38(4):344–353Trends in Immunology.2017. REVIEW| v. 38,I4, P287-297, Saint-Saens, C. 1886. Symphony 3 in C Minor Op.78https://music.youtube.com/watch?v=ZWCZq33BrOo&si=A7uooZ7N9HCELVTK
The Evidence Based Chiropractor- Chiropractic Marketing and Research
In today's episode, we're diving into some brand new, cutting-edge research that turns the spotlight on microglia—the tiny, yet mighty immune cells in your spinal cord. Dr. Jeff explores a recent review published in Frontiers in Immunology that unpacks how microglia play a pivotal role in neuroinflammation, plasticity, and recovery after spinal cord injury.Episode Notes: Evolving insights on the role of microglia in neuroinflammation, plasticity, and regeneration of the injured spinal cordLeander Tables- Save $1,000 on the Series 950 Table using the code EBC2025 — their most advanced flexion-distraction tablePatient Pilot by The Smart Chiropractor is the fastest, easiest to generate weekly patient reactivations on autopilot…without spending any money on advertising. Click here to schedule a call with our team.Our members use research to GROW their practice. Are you interested in increasing your referrals? Discover the best chiropractic marketing you aren't currently using right here!
In this episode of the Ageless Future podcast, Regan Archibald sits down with Dr. Natalia Mitin, a leading researcher in immunology and longevity, to discuss how aging is fundamentally driven by the immune system. Dr. Mitin breaks down complex mechanisms like immunosenescence and T-cell exhaustion and introduces her company's breakthrough SapereX test, which measures immune system age with high precision. They explore why traditional longevity biomarkers like telomeres often miss the mark, and how direct T-cell gene expression provides clinicians with actionable insights. This episode also covers key interventions—from stem cell support to senolytics—and emphasizes the importance of tailoring protocols based on actual biological needs rather than trends. Dr. Mitin and Regan underscore a powerful message: true longevity starts with personalized diagnostics and measured interventions, not guesswork. www.saperex.comhttps://www.linkedin.com/in/nataliamitin/
Cindy speaks with Aimee Pugh Bernard from University of Colorado about her career and her passion for teaching and communicating immunology to the public. Host: Cindy Leifer Guest: Aimee Pugh Bernard Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server More about Aimee on her webpage Funsizeimmuninja on Instagram Fun Size Science video partnership with Unbiased Science Funsizeimmuninja Substack Society for Leukocyte Biology Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
In this episode, we review the high-yield topic of Common Variable Immunodeficiency Disorder (CVID) from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Antigen Processing and Presentation from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Autumn is here, and so are our friends, the dust mites! But what are they, where do they live, and what can we do to avoid them? Christine Loscher, Professor of Immunology at DCU, has the answers!
In this episode, we review the high-yield topic of Primary Lymphoid Tissue from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of IL-12 Receptor Deficiency from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Indolent Systemic Mastocytosis (ISM) is a rare but often underrecognized clonal mast cell disorder. From random hives to gut pain and brain fog, ISM can feel like a medical mystery. We continue our review of “Management of indolent mastocytosis and mast cell activation syndrome - A clinical yardstick,” published in June 2025 in The Annals of Allergy, Asthma & Immunology. This is Part 2 of our discussion, with a focus on indolent systemic mastocytosis. We look at what causes it, how it's diagnosed, and how to manage symptoms and improve quality of life. In this episode, we break down this complex mast cell disease and how doctors use baseline serum tryptase, KIT D816V testing, and HaT screening to find answers. Plus, we explain how treatments like antihistamines, mast cell stabilizers, and avapritinib can help people live better with ISM.
In this episode, we review the high-yield topic of Hyper IgE Syndrome / Job Syndrome from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
What if hair loss was really a signal from your body, not just a cosmetic issue?In this episode, I talk with VJ Hamilton, The Autoimmune Nutritionist, about overcoming alopecia areata and other forms of hair loss by addressing root causes. We dive into nutrient deficiencies, gut health, thyroid imbalances, and inflammation and how functional medicine can help hair grow back naturally.If you've been told there's no hope for hair loss, this episode will challenge that belief.Episode Timeline: 00:00 – Episode Preview02:07 – Podcast Intro02:32 – Meet VJ Hamilton, Autoimmune Nutritionist04:02 – VJ's Story: Alopecia at Age 705:24 – Reversing Fatigue, Psoriasis, and Chronic Issues08:55 – Hair Loss: Autoimmune vs. Other Causes12:58 – Hair Regrowth: Healing Timeline16:09 – Inflammation Triggers: Gut, Scalp, Whole Body18:12 – Five Key Hair Loss Markers25:44 – Biotin: Overrated or Essential?27:50 – Nutrients: Selenium, Vitamin A, Genetics31:29 – Low Stomach Acid and Absorption33:01 – Supplements vs. Food for Hair Growth35:05 – First Steps with Hair Loss Diagnosis36:07 – Complex Cases: Mold, Toxins, Nervous System39:25 – Connect with VJ Hamilton Online40:42 – Podcast Outro41:03 – Root Cause Healing: Final TakeawaysAbout VJ Hamilton:VJ Hamilton, also known as The Autoimmunity Nutritionist, is the founder of The Autoimmune Nutrition Clinic and a Registered Nutritionist specialising in reversing hair loss, particularly alopecia areata, and other autoimmune-related conditions. With a Medical Science degree (BSc) in Biochemistry & Immunology and certification from the Institute for Functional Medicine, VJ combines scientific expertise with lived experience to deliver evidence-based, personalised therapies. Connect with VJ Hamilton:VJ Hamilton's Website: https://theautoimmunitynutritionist.com VJ Hamilton's FB Page: https://www.facebook.com/A.Nutritionist/ To take the Save My Thyroid Quiz visit www.savemythyroid.com/quiz Free resources for your thyroid health Get your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.com High-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto' sHave you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto's, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com. Do You Want Help Saving Your Thyroid? Click Here to access hundreds of free articles and blog posts. Click Here for Dr. Eric's YouTube channel Click Here to join Dr. Eric's Graves' disease and Hashimoto's group Click Here to take the Thyroid Saving Score Quiz Click Here to get all of Dr. Eric's published booksC...
In this episode, we review the high-yield topic of T-Cell Activation from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Mikki Tal, PhD, is a Principal Scientist at MIT's Department of Biological Engineering and Associate Scientific Director of the MIT Center for Gynepathology Research. She leads the Tal Research Group, focusing on host-pathogen interactions, immune responses to infections like Lyme disease, and the mechanisms behind chronic illnesses, particularly their disproportionate impact on women. She earned her PhD in Immunobiology from Yale University and conducted postdoctoral research at Stanford University's Institute for Stem Cell Biology and Regenerative Medicine. Tal was the recipient of our 2018 Bay Area Lyme Foundation Emerging Leader Award.
Listen as pulmonologist Peter Dicpinigaitis discusses his approach to the diagnosis and management of patients with refractory chronic cough in the context of a clinically relevant case and provides insights regarding emerging therapies.PresenterPeter Dicpinigaitis, MDProfessor of MedicineAlbert Einstein College of MedicineDivision of Critical Care MedicineMontefiore Medical CenterDirector, Montefiore Cough CenterBronx, New YorkLink to full program:https://bit.ly/4kweynG
Dr. Eric Vivier is a Professor of Immunology at Aix-Marseille Université and the Centre d'Immunologie de Marseille-Luminy. He is also an awardee of the European Research Council and a member of the French Society of Immunology. In this special episode recorded at the IUIS 2025 Congress in Vienna, Dr. Vivier highlights the critical importance of investing in science, explores the responsibility of governments and other organizations in funding research, and reflects on the role science plays in society.
In this episode, we review the high-yield topic of Immunization from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
First, the La Jolla Institute for Immunology is studying ghost viruses, which are passed down by our ancestors. Then, clean energy projects are getting a boost in funding and new election mailers are headed to your mailbox. Next, how the Carlsbad Theater owners are trying to save its legacy. Finally, we take a look at La Ópera de Tijuana which celebrates their 25 year anniversary.
Send us a textCellular clean up by immune cells and how early-life fructose exposure leads to neurodevelopmental problems.Episode Summary: Dr. Justin Perry talks about the body's constant cellular turnover—about 3 million cells die per second in adults (double in children and women)—handled by phagocytes like macrophages that engulf and digest debris to prevent diseases like lupus. They explore phagocytosis steps, macrophage adaptations in tissues like the brain (microglia), and how high fructose intake impairs microglial function in developing mice, leading to uncleared brain cells and anxiety-like behaviors, with implications for human neurodevelopmental disorders amid rising fructose consumption.About the guest: Justin Perry, PhD is an immunologist and clinical psychologist who leads a lab at Memorial Sloan Kettering Cancer Center focusing on how the body clears dead cells and debris to maintain homeostasis.Discussion Points:The body turns over 1-2% of its 30 trillion cells daily, mostly blood cells, but neurons in kids and endometrium in women turnover at ~2x this ratePhagocytosis involves "find me," "eat me," and digestion signals; failures can cause autoimmunity.Microglia are brain macrophages that uptake fructose via GLUT5 transporter.Early high fructose exposure (comparable to one soda daily) impairs the pruning of synapses and dead neurons.In mice, prenatal or postnatal fructose causes phagocytosis deficits in the prefrontal cortex, leading to heightened fear responses and poor fear extinction, mimicking anxiety disorders.Fructose correlates with rising neurodevelopmental issues like autism and anxiety; it's passed via breast milk, and liquid forms (e.g., sodas) overwhelm metabolic shields more than solid fruits.Macrophages may hold keys to diseases from atherosclerosis to cancer; deleting GLUT5 in microglia reverses fructose's effects, hinting at evolutionary roles in aging or low-oxygen states.Related content:M&M 215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary PattiArticle | Dietary Fructose & Metabolic Health: An Evolutionary PerspectiveReference Paper:Study | Early life high fructose impairs microglial phagocytosis and neurodevelopment*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts
About this episode: Back-to-back crises of the opioid epidemic and COVID-19 have pummeled American communities, eroding trust in public health. But what if restoring that trust could start with a simple conversation? In this episode: Maggie Bartlett shares how she's using her platform as co-host of the podcast, “Why Should I Trust You?”, to forge human connections with those who feel left out of public health conversations and to debunk misinformation about measles, vaccines, and corporate influence. Watch the video episode on YouTube: https://youtu.be/zCx9YY9EBWk Guest: Maggie L. Bartlett, PhD, is an assistant research professor in Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health and the co-host of “Why Should I Trust You?”. Host: Lindsay Smith Rogers, MA, is the producer of the Public Health On Call podcast, an editor for Expert Insights, and the director of content strategy for the Johns Hopkins Bloomberg School of Public Health. Show links and related content: Inside A Rare Conversation Between MAHA Grassroots and Public Health Leaders—Why Should I Trust You? What I'm Learning from MAHA—Your Local Epidemiologist Why Should I Trust You?—www.whyshoulditrustyou.net Transcript Information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @PublicHealthPod on Bluesky @JohnsHopkinsSPH on Instagram @JohnsHopkinsSPH on Facebook @PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.
Immune discusses how cancer cells swap mitochondria with T cells and then digs in for a discussion of an unusual checkpoint blockade that failed for cancer but could be repurposed for autoimmune inflammation. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Cancer cells steal mitochondria from neurons for metastasis (Nature 2025) Cancer cells donate damaged mitochondria to T cells to impair them (Nature 2025) PD-L1 binding to CD80 on the same dendritic cell needed for migration (Sci Adv 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
Over 50 million Americans suffer from a range of frustrating allergy symptoms from hay fever to asthma, hives to sinusitis. Many have tried medications, visited allergists, and used various treatments, desperate to find a reliable way to alleviate their pain, but just can't seem to get the dependable relief they need. Now, one of New York's top allergists, Dr. Dean Mitchell, lifts the cloud of mystery surrounding allergies and offers a breakthrough new treatment program that will dramatically lessen their severity, if not cure them for good. In Dr. Dean Mitchell's Allergy and Asthma Solution, Mitchell clearly and comprehensively explains what allergies are, why they are so prevalent, and all of the standard treatments. He then presents a cutting edge 5-step program for reversing allergies called sublingual immunotherapy, or "allergy drops." This new treatment, widely accepted in Europe but still relatively unknown in the United States, is painless, convenient, incredibly effective, and completely safe since it works naturally through the body's immune system. Even better, it can be customized to meet specific needs, is shot-free, and can be self-administered. Dr. Dean Mitchell's Allergy and Asthma Solution is the best guide to understanding allergies and overcoming their symptoms.Dean Mitchell, MD, is the leading expert in sublingual allergy immunotherapy in the United States. He had been in practice for seven years following the conventional methods of allergy cures when he first learned of sublingual allergy immunotherapy (allergy drops) and has been one of its strongest proponents. He now runs a private practice, Ocean Allergy & Nutrition, in Manhattan. Dr. Mitchell's patients come from all over the US to receive his treatments. He is a fellow of the American College of Allergy, Asthma, and Immunology and is a member of the Joint Council of Allergy and Immunology.For ten years he was a clinical instructor of medicine at Columbia College of Physicians and Surgeons. He graduated from Brown University in 1982 and received his MD from the Sackler School of Medicine at Tel Aviv University in 1986. He lives in Long Island with his wife and two sons. When he's not busy with his patients, he enjoys playing baseball with his kids.https://www.mitchellmedicalgroup.com/about/dr-dean-mitchell/?utm_source=google&utm_medium=referral&utm_campaign=gmb_dean?utm_source=GMB&utm_medium=DeanBecome a supporter of this podcast: https://www.spreaker.com/podcast/earth-ancients--2790919/support.
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