Podcasts about Immunology

Branch of medicine studying the immune system

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Best podcasts about Immunology

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Latest podcast episodes about Immunology

Future Generations Podcast with Dr. Stanton Hom
305: Uninjected but Not Safe: Nanotech, Shedding, and the Human Data Center with Maria Crisler

Future Generations Podcast with Dr. Stanton Hom

Play Episode Listen Later Jul 20, 2026 65:29


It's time to build your family's future on a foundation of true health and freedom. Join us at Future Foundations—because your future generations deserve the best start to the mission that will outlive us… Check it out here. Use code FREEDOM25 for 25% off!    Whether you're looking for tinctures, topicals or teas or a deeper connection to your INNATE healing capacity, Noble Task Homestead is here to serve you. Join the movement. Visit NobleTaskHomestead.com/noblestan today and enjoy a 10% discount on your order.   San Diego area residents, take advantage of our special New Patient offer exclusively for podcast listeners here. We can't wait to experience miracles with you!   Welcome to another episode of the Future Generations Podcast. Today Dr. Stanton Hom sits down with nanoscientist and clinical lab expert Maria Crisler to expose what she's actually seeing under the microscope in both injected and uninjected populations. They unpack the transhuman agenda, smart dust, hydrogels, synthetic fascia, and why classic detox and "healthy lifestyle only" are no longer enough, then lay out the core principles of Maria's remediation program to protect our kids and future generations.   Highlights: "The blood doesn't lie, and biology is not the invader here."   "There is no such thing as safe blood anymore."   "If you own a cell phone, game over. These smart particles are activated by your environment."   "If you do nothing, it doesn't matter if you're injected or not, you're part of the problem."   Timestamps: 00:02 – Introduce 00:00 – Health Freedom as a Family Legacy 04:18 – Meet Maria: Lab Scientist Turned Nanoscience Whistleblower 08:48 – What Maria Sees in "Uninjected" Kids' Blood 11:58 – Stanton on Unvaccinated Injury, Shedding, and Smart Infrastructure 16:52 – "There Is No Safe Blood": Contamination of the Uninjected 24:23 – Is Our Environment Now More Synthetic Than Biological? 32:22 – Endocannabinoid System Under Attack & Why It Matters for Kids 42:08 – Human Data Centers, AI, and the Bio-Internet of Bodies 47:18 – Why Zeolite, Silica & Common Detoxes May Be Backfiring 59:03 – The Organism Detox Program: Synthetic, Hybrid, and Organic Cleanup   Resources:   Remember to Rate, Review, and Subscribe on iTunes and Follow us on Spotify!   Learn more about Dr. Stanton Hom on:   Instagram: https://www.instagram.com/drstantonhom    Website: https://futuregenerationssd.com/  Podcast Website: https://thefuturegen.com  Twitter: https://twitter.com/drstantonhom   LinkedIn: https://www.linkedin.com/in/stanhomdc   Stay Connected with the Future Generations Podcast:   Instagram:  https://www.instagram.com/futuregenpodcast   Facebook: https://www.facebook.com/futuregenpodcast/     About Maria Crisler: Maria Crisler: Founder and CEO of Abeytu Naturals    A.S., B.S., CLS (NCA), MBA/HCM   She is a successful medical business owner with extensive expertise in Clinical Microbiology and Immunology. In addition to executive leadership and management responsibilities, Maria is actively involved in clinical product design and development. She plays a key role in identifying consumer needs and facilitating effective applications for individuals with chronic conditions across the supplement, medical, and pharmaceutical industries. Social Links:   ~ Website: https://abeytunaturals.com/pages/about   ~ Facebook: https://www.facebook.com/share/1BE9RytauX/?mibextid=wwXIfr   ~ Facebook: https://www.instagram.com/abeytu_naturals?igsh=MXFpYjI2dWd0cmlnOA==  ~ Pin: https://pin.it/68YzrVWlu    The desire to go off grid and have the ability to grow your own food has never been stronger than before. No matter the size of your property, Food Forest Abundance can help you design a regenerative layout that utilizes your resources in the most synergistic and sustainable manner. If you are interested in breaking free from the system, please visit www.foodforestabundance.com and use code "thefuturegen" to receive a discount on their incredible services.   Show your eyes some love with a pair of daylight or sunset (or both!) blue-light blocking glasses from Ra Optics. They have graciously offered Future Generations podcast listeners 10% off any purchase. Use code FGPOD or click here to access this discount, and let us know how your glasses are treating you!   One of the single best companies whose clean products have supported the optimal wellness of our family is Earthley Wellness. Long before there was a 2020, Kate Tetje and her team have stood for TRUTH, HEALTH and FREEDOM in ways that paved the way for so many of us. In collaboration with this incredible team, we are proud to offer you 10% off of your first purchase by shopping here.   Are you concerned about food supply insecurity? Our family has rigorously sourced our foods for over a decade and one of our favorite sources is Farm Match and specifically for San Diego locals, "Real Food Club PMA". My kids are literally made from their maple breakfast sausage and the amazing carnitas we make from their pasture raised pork. We are thrilled to share 10% off your first order when you shop at this link.   Another important way to bolster food security is by supporting local ranchers. Our favorite local regenerative ranch is Perennial Pastures. They have the best nutrient-dense meats that are 100% grass-fed and pasture-raised. You can get $10 off of your first purchase when you use the code: "FUTUREGENERATIONS" at checkout. Start shopping here.

The Better Life with Dr. Pinkston Podcast
The Science of Vaccines: Balancing Integrative Health and Objective Truth with Dr. Michael Myers Jr.

The Better Life with Dr. Pinkston Podcast

Play Episode Listen Later Jul 18, 2026 48:25


In this episode of The Better Life, Dr. Pinkston sits down with Harvard-trained physician, consultant, and author Dr. Michael Myers Jr. to tackle the complex and often controversial topic of vaccines through the lens of sound science and clear data. With deep expertise as a former chief of primary care and pediatrics, Dr. Myers previews his upcoming book, The Vaccine Bible, and unpacks how immunization works as a reliable tool for long-term health and disease prevention. Together, Dr. Pinkston and Dr. Myers address the most common concerns shared by patient communities today, including the safety of combination shots, the reality of preservatives, and the thoroughly debunked links between vaccines and autism. They look closely at the critical role vaccines play in modern longevity—highlighting massive clinical wins like the shingles vaccine’s link to reduced dementia risk, and cancer-preventing tools like the Gardasil and Hepatitis B vaccines. Dr. Myers also breaks down the rapid development and safety of mRNA technology used during the COVID-19 pandemic. Tune in for an honest, evidence-based conversation that bridges the gap between integrative health practices and conventional immunology, empowering you to perform your own objective risk assessment for you and your family. https://www.drmikemyers.com/ See omnystudio.com/listener for privacy information.

The Paul W. Smith Show
Health Effects of Wildfire Smoke

The Paul W. Smith Show

Play Episode Listen Later Jul 17, 2026 8:29


July 17, 2026 ~ Dr. Christian Nageotte, service chief of Allergy and Immunology at Henry Ford West Bloomfield Hospital discusses health effects of the wildfire smoke. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Immunology Podcast
Ep. 136: “The Immunology of Obesity” Featuring Dr. Andrew Hogan

The Immunology Podcast

Play Episode Listen Later Jul 14, 2026 76:07


Guest: Dr. Andrew Hogan is a Professor and Principal Investigator of the Obesity Immunology Research Group at Maynooth University. He discusses how obesity drives chronic inflammation and immune dysfunction, increasing the risk of diseases such as diabetes and cancer, while highlighting the immune system’s role in disease progression. He also explains how GLP-1 therapies improve both metabolism and immune function, offering new insights into obesity treatment. Featured Products and Resources: Request your free EasySep sample and share your experience for a chance to win prizes worth up to $3,000! Win 350 US dollars or equivalent toward refreshments to fuel your journal club discussions. The Immunology Science Round Up Innate Immunity Predicts Symptoms – Stronger innate immune responses predisposed people to influenza symptoms while also promoting antiviral immune activation. Broad HIV Neutralization #1 – A novel HIV immunogen induced broadly neutralizing antibodies in macaques, providing a promising blueprint for HIV vaccine development. Broad HIV Neutralization #2 – A germline-targeting vaccine induced broadly neutralizing HIV antibodies in nonhuman primates. CAR-T Targets Glioblastoma – A dual-targeting CAR-T therapy achieved durable glioblastoma control in preclinical models. Image courtesy of Dr. Andrew Hogan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

RTÉ - Drivetime
Being a sports fan is good for you

RTÉ - Drivetime

Play Episode Listen Later Jul 13, 2026 7:57


Professor Luke O'Neill, School of Biochemistry & Immunology at Trinity College Dublin

Food Safety Matters
MilliporeSigma: Uncharted Territory—Food Risks, Rapid Responses, and the Race to Adapt

Food Safety Matters

Play Episode Listen Later Jul 9, 2026 51:53


Sally Powell Price, PG.Dip., M.Sc. joined MilliporeSigma in 2020 as a Regulatory Subject Matter Expert for Public Health focusing on food safety, testing, and environmental monitoring in North America. Previously, she served as Food and Environmental Lab Supervisor at the New York City Department of Health Public Health Laboratory, and as Director of Lab Operations at a Boston-based startup. She holds a bachelor's degree in Biology from Hamilton College and an M.Sc. degree in Microbiology and Immunology from James Cook University (Australia), and completed her professional training at Harvard T.H. Chan School of Public Health. Sally currently co-chairs both the International Government Relations Committee and the Laboratory Science and Technology Committee for the Association of Food and Drug Officials (AFDO). She is a member of the World Health Organization (WHO) Food Safety Communities of Practice and has served as an Advisory Panel member for several AOAC International working groups.  Justyce Jedlicka, M.B.A. works in North America Commercial Applications for Food, Beverage, and Industrial Regulatory for MilliporeSigma, where she is responsible for engaging with influencers in the food and beverage industry to align initiatives with regulatory compliance and promote best practices for food safety and quality testing methods. Justyce has been serving the food and beverage industry since 2013, and received both a B.S. degree in Chemistry and an M.B.A. degree from the University of Missouri in St. Louis. She previously served as the Chair of the Food Sciences Section of the American Council of Independent Labs (ACIL) and currently serves on the Food Science Section Executive Committee at ACIL and the Board of Directors for the Independent Laboratory Institute. She is a member of IAFP, ISBT, SMA, and AOAC. In this episode of Food Safety Matters, we speak with Sally and Justyce [2:51] about: Emerging food risks in North America, and how the concept of a "food risk" has evolved over the past decade Differences and similarities in how regulators are handling novel versus established food risks What a rapid and agile response to a food risk might look like, whether such a response exists in North America, and whether existing regulatory frameworks can become more proactive than reactive Manufacturers' challenge of balancing speed-to-market with regulatory compliance in an evolving risk landscape The greatest tensions between food innovation and regulatory readiness in the North American market Whether contract laboratories and testing laboratories are equipped to keep pace with emerging food risks How companies can future-proof their testing and compliance strategies The role that scientific partners like MilliporeSigma play in helping regulators and manufacturers become more agile in an evolving food risk landscape. Resources MilliporeSigma for Food Safety Sponsored by: MilliporeSigma We Want to Hear from You! Please send us your questions and suggestions to podcast@food-safety.com

Authentic Biochemistry
Myeloid/Lymphoid Communication Network As Circulatory Cellular Organ A Biochemical Paradigm VI Authentic Biochemistry Podcast Dr Daniel J Guerra 07July26

Authentic Biochemistry

Play Episode Listen Later Jul 8, 2026 56:30


References Nat Struct Mol Biol . 2006 Dec;13(12):1097-101Open Biol. 2013 Oct;3(10):130144Arthritis Res Ther.2021; 23: 19.European Review for Medical and Pharmacological Sciences 2021; 25: 1425-1435Frontiers in Immunology 2024 09 January DOI 10.3389/fimmu.2023.132280Guerra, DJ. 2026.Unpublished Lectures.Teleman, G P 1716. Concerto in D. TWV51 https://music.youtube.com/watch?v=F5J80v3ACbo&si=oiJxKkpbnLhiZ833Hunter/Garcia.1973. Stella Blue. Grateful Dead.https://music.youtube.com/watch?v=VKsWDyvWaL4&si=Jul71w1djWl2WTIIp. 1716. D1 TWV51.

Authentic Biochemistry
Myeloid/Lymphoid Communication Network As Circulatory Cellular Organ A Biochemical Paradigm V Authentic Biochemistry Podcast Dr Daniel J Guerra 06July26

Authentic Biochemistry

Play Episode Listen Later Jul 7, 2026 59:45


ReferencesFrontiers in Immunology 2014. November 21(578):1Clin Epigenetics. 2017; 9: 94. Cancer Cell International 2020. September 20(1):429Guerra, DJ.2026. Unpublished Lectures.Vinsom/Chapman/Burnett. 1930. Sitting On Top of the World Creamhttps://open.spotify.com/track/0aY5bJ4jRHiOd8eCMWmcy8?si=b3c7f2090c6e441cJagger/Richards.1965.Satisfaction Rolling Stoneshttps://open.spotify.com/track/2PzU4IB8Dr6mxV3lHuaG34?si=6b244c676bf1454eLennon/McCartney. 1968 Helter Skelterhttps://open.spotify.com/track/0Bs0hUYxz7REyIHH7tRhL2?si=f345fea1161a4f27Paige/ Plant 1971. Rock and Roll Led Zepplinhttps://open.spotify.com/track/4PRGxHpCpF2yoOHYKQIEwD?si=3203893185c24bee

RTÉ - News at One Podcast
Researchers discover types of bacteria living inside a woman's womb may affect IVF and other fertility treatments

RTÉ - News at One Podcast

Play Episode Listen Later Jul 6, 2026 3:23


The study from Trinity College in Dublin, Professor Cliona O'Farrelly, from Trinity's School of Biochemistry and Immunology who led the study spoke to Rachael.

Progress, Potential, and Possibilities
Beyond Immunosuppression: The Rise of T-Cell Engagers for Autoimmune Disease | Dr. Jeffrey Jones, MD, MPH - Chief Medical Officer, Cullinan Therapeutics

Progress, Potential, and Possibilities

Play Episode Listen Later Jul 6, 2026 55:21


Send us Fan MailFor decades we've treated autoimmune diseases by suppressing the immune system - but what if we've been approaching the problem all wrong? What if, instead of lifelong immunosuppression, we could selectively eliminate the immune cells causing disease and allow the immune system to rebuild itself? Today we're exploring one of the hottest areas in biotechnology: T-cell engagers and the possibility of an "immune reset."Dr. Jeffrey Jones, MD, MPH is Chief Medical Officer of Cullinan Therapeutics ( https://cullinantherapeutics.com/ ) and one of the leaders helping bring the power of T-cell engager therapies beyond cancer and into autoimmune disease. With more than two decades of experience spanning academia and industry, Dr. Jones has been at the forefront of clinical development in hematology, oncology, and immunology.Prior to joining Cullinan, Dr. Jones served as Vice President of Global Drug Development at Bristol Myers Squibb, leading programs in lymphoma and myeloid diseases and helping guide the lifecycle strategy for Reblozyl®. Earlier, he held leadership positions at Celgene, where he developed clinical strategies across lymphoma and chronic lymphocytic leukemia portfolios.Before entering industry, Dr. Jones spent more than a decade at The Ohio State University, where he led the Chronic Lymphocytic Leukemia clinical research program and served as Associate Professor of Internal Medicine. Today, he is helping pioneer a new generation of T-cell engagers designed not to continuously suppress the immune system, but potentially to reset it - opening the possibility of durable, treatment-free remission for diseases such as rheumatoid arthritis, lupus, lupus nephritis, and autoimmune cytopenias.Dr. Jones earned his MD from the University of Michigan Medical School, an MPH from the University of Texas School of Public Health, and an MBA from The Ohio State University Fisher College of Business.#AutoimmuneDisease #Lupus #RheumatoidArthritis #Immunology #TCellEngagers #Biotechnology #DrugDevelopment #PrecisionMedicine #ImmuneSystem #ImmuneReset #ClinicalTrials #Biotech #HealthcareInnovation #FutureOfMedicine #ProgressPotentialPossibilitiesSupport the show

The Tucker Carlson Show
The Number One Way to Fight Alzheimer's, Depression and Anxiety Before It's Too Late

The Tucker Carlson Show

Play Episode Listen Later Jul 3, 2026 86:35


Scientist and physician Michael Nehls explains how Alzheimer's can be reversed. Michael Nehls, MD, PhD, is a physician and molecular geneticist. As a basic researcher, he has deciphered the genetic causes of various hereditary diseases at German and international research institutions. He has published two of his discoveries in collaboration with several Nobel laureates. His discovery of a key gene in the development of immunity was honored as a "Pillar of Immunology" by the prestigious American Association of Immunology. A science writer with a talent for making complex issues accessible to a wide audience, he has written several best-selling books that have been translated into many languages. As a private lecturer, he is a popular speaker at conferences and universities. Find him here: Substack: michaelnehls.substack.com Web: https://michael-nehls.com X: @NehlsMD Paid partnerships with: Angel Studios: Become a Premium Angel Guild member today at http://angel.com/TuckerCharity Mobile: A pro-life company serving pro-life customers and supporting pro-life causes for 30 years. Use promo code TUCKER to get a free phone with free activation, free shipping, and a free gift with every new line of service at https://charitymobile.com/Tucker VanMan: Use code TUCKER for 15% off your first order at http://vanman.shop/tucker Learn more about your ad choices. Visit megaphone.fm/adchoices

Authentic Biochemistry
Melatonin/Sirtuins/NAD in Circadian Clock Oscillations XVFine 30.6.26 Authentic Biochemistry Podcast Dr. Daniel J Guerra

Authentic Biochemistry

Play Episode Listen Later Jul 1, 2026 55:44


ReferencesGut 2004;53:480–486. Immunol Rev 2014., 261: 62-83Nat Immunol. 2019 Aug 12;20(9):1174–1185.The Journal of Immunology, 2026.Volume 215, Issue 5, May vkag103Guerra, DJ. 2026. Unpublished LecturesMozart, WA. 1788. Divertimento String Trio in E Flat Major K.563https://music.youtube.com/watch?v=WNse4T666Ss&si=4cTDzDE4E-mX9NVz

On the Mend
Neglected No More: Shining a Light on Schistosomiasis, Hope for a Parasitic Cure

On the Mend

Play Episode Listen Later Jun 30, 2026 14:32


Send us Fan MailMore than 200 million people around the world are infected with schistosomiasis, one of the neglected tropical diseases. It is caused by parasitic worms and prevalent in Africa, the Middle East, South America and Asia with close to 800 million people at risk for infection. If we in the U.S. are not in immediate threat of contracting the disease, why should we want to know more about it? To answer that and to explain more about the disease –– how people are infected, who is at risk, what the symptoms are and how it's currently treated –– is Afzal Siddiqui, Ph.D., a Grover E. Murray Distinguished Professor, director of the TTUHSC Center for Tropical Medicine and Infectious Diseases and chair of the Department of Immunology and Molecular Microbiology in TTUHSC's School of Medicine. Siddiqui also shares with us his decades-long work as part of a team developing a vaccine, updates us on the progress of the clinical trials and how work done on this vaccine could be useful to develop other vaccines as well. About SchistoShield®

Future Generations Podcast with Dr. Stanton Hom
302: The FBI Showed Up at His Door. He Refused to Stop Speaking Out: Dr. Patrick Flynn's Story

Future Generations Podcast with Dr. Stanton Hom

Play Episode Listen Later Jun 29, 2026 49:36


Join the Wealthy Practitioner Tour with Dr. Stephanie Wigner this August! Visit the Wealthy Practitioner Tour to get your tickets today. It's time to build your family's future on a foundation of true health and freedom. Join us at Future Foundations—because your future generations deserve the best start to the mission that will outlive us… Check it out here. Use code FREEDOM25 for 25% off!    Whether you're looking for tinctures, topicals or teas or a deeper connection to your INNATE healing capacity, Noble Task Homestead is here to serve you. Join the movement. Visit NobleTaskHomestead.com/noblestan today and enjoy a 10% discount on your order.   San Diego area residents, take advantage of our special New Patient offer exclusively for podcast listeners here. We can't wait to experience miracles with you!   Welcome to a new episode of the Future Generations Podcast! Today, Dr. Stanton Hom sits down with Dr. Patrick Flynn, a chiropractor, immunology geek, and founder of a rapidly growing network of clinics known for life-changing clinical results. In this episode, they unpack the clash between the dominant medical "firefighter" model and a chiropractic "carpenter" paradigm that sees the body as intelligently adaptive, not broken. From trauma, toxins, and thoughts to auto-suggestion, vaccines, fertility, and the gut–brain–immune connection, Dr. Flynn lays out how chiropractic thinking reshapes labs, lifestyle, and long-term outcomes. You'll hear real clinical stories, hard questions about responsibility and prevention, and a powerful call for chiropractors and patients alike to reclaim a vitalistic, principle-driven approach to health and freedom.   Highlights: "You don't see the world the way it is, you see the world the way you are."    "True preventative health care is more of a chiropractic principle."    "A true scientist will always have a comma in his sentence, not a period."   "I'm a chiropractor. That just separates me from the thinking that dominates us today."    Timestamps: 00:00 - Introduction 01:39 – Medical vs. Chiropractic: Two Different Paradigms 03:31 – Innate Intelligence and the Adaptive Body 05:55 – Fever, Intelligence, and Misunderstood Symptoms 06:45 – Prenatal Case: Gestational Diabetes & Nervous System State 12:45 – Auto-Suggestion, Brainwashing, and Immune Collapse 18:24 – Firefighters vs. Carpenters: A New Healthcare Analogy 20:49 – What They Don't Tell You About Vaccines and Inflammation 36:29 – The Holistic Health Trap & Responsibility 42:17 – FBI at the Door & Standing on Principle Resources:   Remember to Rate, Review, and Subscribe on iTunes and Follow us on Spotify!   Learn more about Dr. Stanton Hom on:   Instagram: https://www.instagram.com/drstantonhom    Website: https://futuregenerationssd.com/  Podcast Website: https://thefuturegen.com  Twitter: https://twitter.com/drstantonhom   LinkedIn: https://www.linkedin.com/in/stanhomdc   Stay Connected with the Future Generations Podcast:   Instagram:  https://www.instagram.com/futuregenpodcast   Facebook: https://www.facebook.com/futuregenpodcast/     About Dr. Patrick Flynn: Dr. Patrick Flynn is a chiropractor and the founder of The Wellness Way. He is a highly sought-after speaker and best-selling author with educational training from numerous learning institutions including Palmer College of Chiropractic, The University of Wisconsin Green Bay, The University of Wisconsin Marinette, Scott College, Northwestern Health Sciences University, National University of Health Sciences, and courses at Harvard Medical School – HMX Fundamentals Online Certificate Program – in Immunology, Virology and Vaccines, and Health and Wellness: Designing a Sustainable Nutrition Plan. Pioneering a different approach to healthcare, he has trained Chiropractors, M.D.s, Nurse Practitioners, Nurses, Surgeons, Pharmacists, Health Restoration Coaches, and others. His network is now comprised of over 60 clinics seeing people from around the world. Find Him on Social Media Here: Instagram: https://www.instagram.com/drpatrickflynn/ YouTube: https://www.youtube.com/@DrPatrickFlynnDC TikTok: https://www.tiktok.com/@dr..patrick.flynndc Facebook: https://www.facebook.com/drpatrickflynn/ The desire to go off grid and have the ability to grow your own food has never been stronger than before. No matter the size of your property, Food Forest Abundance can help you design a regenerative layout that utilizes your resources in the most synergistic and sustainable manner. If you are interested in breaking free from the system, please visit www.foodforestabundance.com and use code "thefuturegen" to receive a discount on their incredible services.   Show your eyes some love with a pair of daylight or sunset (or both!) blue-light blocking glasses from Ra Optics. They have graciously offered Future Generations podcast listeners 10% off any purchase. Use code FGPOD or click here to access this discount, and let us know how your glasses are treating you!   One of the single best companies whose clean products have supported the optimal wellness of our family is Earthley Wellness. Long before there was a 2020, Kate Tetje and her team have stood for TRUTH, HEALTH and FREEDOM in ways that paved the way for so many of us. In collaboration with this incredible team, we are proud to offer you 10% off of your first purchase by shopping here.   Are you concerned about food supply insecurity? Our family has rigorously sourced our foods for over a decade and one of our favorite sources is Farm Match and specifically for San Diego locals, "Real Food Club PMA". My kids are literally made from their maple breakfast sausage and the amazing carnitas we make from their pasture raised pork. We are thrilled to share 10% off your first order when you shop at this link.   Another important way to bolster food security is by supporting local ranchers. Our favorite local regenerative ranch is Perennial Pastures. They have the best nutrient-dense meats that are 100% grass-fed and pasture-raised. You can get $10 off of your first purchase when you use the code: "FUTUREGENERATIONS" at checkout. Start shopping here.

The School of Doza Podcast
Signs Your Gut microbiome Is Out of Balance And What to Do About It

The School of Doza Podcast

Play Episode Listen Later Jun 29, 2026 33:36


Nurse Doza breaks down five signs your gut microbiome may be off — a history of antibiotics, brain fog, autoimmune issues, relentless sugar cravings, and not pooping every day. He explains how gut bacteria help shape neurotransmitters, blood sugar, and natural GLP-1, why so many issues trace back to the gut, and the simple steps — fasting, fermented foods, fish oil, and the Good Poops Protocol — that can help rebuild it from the inside out. FEATURED PARTNER — Good Poops Protocol (MSW Nutrition) This episode centers on rebuilding the gut microbiome, and the Good Poops Protocol is the bundle Nurse Doza built for exactly that — Gut, Liver Boost, and Berberine Plus working together over 60 days to support the intestinal lining, healthy bile flow, and blood-sugar metabolism. Berberine and L-glutamine are both studied for supporting the body's own GLP-1 production, making the protocol a practical starting point for the digestive issues discussed in this episode.

Have You Herd? AABP PodCasts
Epi. 298 – AABP Preconference Seminars

Have You Herd? AABP PodCasts

Play Episode Listen Later Jun 29, 2026 28:15


AABP Executive Director Dr. Fred Gingrich is joined by AABP Vice President and Preconference Seminar Coordinator Dr. Elizabeth Quesnell Kohtz. Preconference seminars are small group courses focusing on a specific topic offering high quality continuing education. Seminars are a great way to learn a new skill or advance skills to offer services to your beef and dairy clients.  Seminars are approved for eight hours per day of continuing education in jurisdictions that recognize RACE approval. These courses are an AABP member benefit and available to members who are veterinarians, veterinary technicians and students. There will be six seminars offered at the conference. There is also a student-only lameness seminar that will also be offered. Seminars available at the Minneapolis conference are below. Click on the name of the seminar to view a description and detailed agenda. Seminar 1 – Milk quality: Practical knowledge for boots on the ground veterinariansSeminar 2 – Bovine Dystocia and Fetotomy SeminarSeminar 3 – Transition cow health and managementSeminar 4 – From anecdote to evidence: conducting impactful field research in private practiceSeminar 5 – Immunology and vaccinology across beef and dairy production systemsSeminar 6 – Anesthesia, analgesia and sedation All conference information can be found under the Continuing Education menu of the AABP website. View session descriptions here. Register for the conference by going to this link. Early bird discounted registration ends July 16 so register before that date. Hotel information can be found on this page. Seminars with an inadequate number of registrations on July 16 are subject to cancellation with a full refund available if cancelled.  #AABP2026  

Progress, Potential, and Possibilities
Systemic Oncolytic Virotherapy Explained | Dr. Eric Poma, Ph.D. - CEO - Calidi Biotherapeutics

Progress, Potential, and Possibilities

Play Episode Listen Later Jun 29, 2026 36:11


Send us Fan MailFor decades, scientists have searched for better cancer drugs. But what if the biggest challenge isn't discovering the drug - it's getting it to the tumor? My guest today is developing programmable viruses designed to travel throughout the body, selectively amplify inside metastatic lesions, and transform tumors into factories for their own destruction.Dr. Eric Poma, Ph.D. is Chief Executive Officer of Calidi Biotherapeutics ( https://www.calidibio.com/ ), a biotechnology company developing targeted genetic medicines designed to deliver therapeutic payloads directly to tumors throughout the body.Dr. Poma brings more than three decades of experience across biotechnology, oncology drug development, business development, and capital markets. Prior to joining Calidi in 2025, he served as CEO of Molecular Templates, where he helped raise more than $250 million in equity financing and secured strategic partnerships with companies including Takeda, Vertex, and Bristol Myers Squibb.Earlier in his career, Dr. Poma held leadership roles at ImClone Systems during the rise of targeted cancer therapies, served as Vice President of Business Development at Innovive Pharmaceuticals, and worked as a healthcare and biotechnology analyst. He holds a Ph.D. in Microbiology and Immunology from the University of North Carolina at Chapel Hill and an MBA from NYU's Stern School of Business.Today we will discuss one of the most difficult challenges in oncology - how to successfully deliver powerful therapies to metastatic tumors throughout the body - and how Calidi's RedTail platform aims to use engineered oncolytic viruses as targeted delivery vehicles capable of reaching cancer cells, modifying the tumor microenvironment, and potentially enabling a new generation of genetic medicines.#CancerResearch #Oncology #Immunotherapy #GeneTherapy #Biotechnology #CancerTreatment #PrecisionMedicine #OncolyticVirus #CancerScience #BiotechInnovation #MetastaticCancer #IL15 #VacciniaVirus #GeneticMedicine #SyntheticBiology #TumorMicroenvironment #FutureOfMedicine #DrugDelivery #Biopharma #EricPoma #CalidiBiotherapeutics #CancerBreakthrough #MedicalInnovation #LifeSciences #ProgressPotentialPossibilitiesSupport the show

Highlights from The Pat Kenny Show
Luke O'Neill on European Science

Highlights from The Pat Kenny Show

Play Episode Listen Later Jun 27, 2026 9:31


In advance of Ireland's upcoming European Presidency, Pat talks to Luke O'Neill, Professor of Biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin, about the European Research Council's recent meeting in Dublin, and how Europe compares with the rest of the world in science and technology.

How This Is Building Me
S2 Ep12: How Strategic Focus Translates to Forward Momentum Across Cancer Immunology Frontiers: With D. Ross Camidge, MD, PhD; and Nora L. Disis, MD

How This Is Building Me

Play Episode Listen Later Jun 24, 2026 71:59


How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life's experiences.In this episode, Dr Camidge sat down with Mary (Nora) L. Disis, MD, a professor in the Clinical Research Division at Fred Hutchinson Cancer Center; as well as a professor in the Division of Hematology and Oncology, an adjunct professor of pathology in obstetrics and gynecology, holder of the Helen B. Slonaker Endowed Professorship for Cancer Research, director of the Cancer Vaccine Institute, and associate dean for Translational Health Science at the School of Medicine at the University of Washington in Seattle.Drs Camidge and Disis discussed Dr Disis's evolution from a science-focused student to a global leader in cancer immunology. Raised in a family that prioritized education, Disis found her passion for chemistry as a young adult before pursuing an MD and a master's degree. Although deeply drawn to practicing medicine in rural communities, she ultimately chose to focus on the field of tumor immunology.In the discussion, Disis offered a candid look at the strategic discipline required to succeed as a clinician-scientist. She emphasized the importance of protecting research time and refusing to let clinical duties overshadow her lab work. Her pioneering research involved identifying HER2 as a tumor antigen and developing vaccines that demonstrated significant long-term survival through intermolecular epitope spreading.Beyond the lab, Disis highlighted how her editorial roles allow her to observe scientific trends and maintain a broad understanding of the clinical landscape. Ultimately, Disis emphasized that the path to cancer prevention and vaccine licensing requires finance, focus, fortitude, and fearlessness. Having witnessed immunotherapy become a standard of care, she remains dedicated to climbing the mountain of vaccine development. By sifting through scientific “buzz” and maintaining deep focus, Disis believes the next frontier of cancer research lies in immunizing individuals to prevent cancer from ever developing.

BackTable ENT
Ep. 279 Collaborative Care in Chronic Sinusitis & Allergies with Dr. Karen Kaufman

BackTable ENT

Play Episode Listen Later Jun 23, 2026 58:42


When should recurrent sinus infections trigger an allergy or immune workup? In this episode of the BackTable ENT and Allergy podcast, Dr. Karen Kaufman of Kaufman Allergy, Asthma, & Immunology in Vienna, Virginia, sits down with Dr. Ashley Agan to discuss chronic sinusitis evaluation, allergy testing, immunotherapy, immune deficiency screening, and building a private practice. --- Get the BackTable apphttps://www.backtable.com/app --- Timestamps 00:00 - Introduction02:53 - Chronic Sinusitis Basics06:44 - Sinusitis Types and Polyps10:18 - Testing and Treatment Plan18:40 - When to Suspect Immunodeficiency25:44 - Allergy Testing Methods38:39 - Why Go Solo43:10 - Practice Growth, Visibility, Team Building, and Systems51:55 - ENT and Allergy Collaboration55:50 - Closing Remarks --- More about this episode Dr. Kaufman explains how to distinguish chronic sinusitis from other causes of nasal and facial symptoms, when to evaluate for allergy and immune dysfunction, and how sinusitis phenotypes influence treatment decisions. She also shares her experience launching a private practice during the pandemic and discusses strategies for practice growth through community engagement, increased visibility, and social media. --- Resources Dr. Karen Kaufman - https://kaufmanallergy.com/ Jeffery Modell Foundation 10 Warning Signs of Primary Immunodeficiency - https://www.uhhospitals.org/-/media/files/rainbow/services/allergy-and-immunology/10warningsigns.pdf --- BackTable ENT & Allergy is the go-to podcast for otolaryngologists, allergists, and head and neck surgeons. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

Public Health On Call
A New Test for Lyme Disease, Developed by High Schoolers

Public Health On Call

Play Episode Listen Later Jun 17, 2026 11:51


About this episode:   A group of students from suburban Atlanta has developed a new method for detecting Lyme disease using the gene-editing tool CRISPR. In this episode: why there's such a desperate need for a new diagnostic, how the students' model works, and why it's so promising for the treatment of Lyme and other diseases.  Guest:  Nicole Baumgarth, PhD, DVM, is Bloomberg Distinguished Professor in Molecular Microbiology and Immunology and the director of the Lyme and Tickborne Disease Research and Education Institute at the Johns Hopkins Bloomberg School of Public Health.  Sankalp Yeleti is a recent graduate of Lambert High School and a rising freshman at New York University, where he plans to study biomolecular science.  Host:  Lindsay Smith Rogers, MA, is the producer of the Public Health On Call podcast, an editor for Expert Insights, and the director of content strategy for the Johns Hopkins Bloomberg School of Public Health.  Show links and related content:  Teens may have come up with a new way to detect, treat Lyme disease using CRISPR gene editing—CBS News  Lancet—Lambert iGEM 2025 Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌PublicHealthPod on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

Matters Microbial
Matters Microbial #132: What 83,000 Generations of Bacteria Reveal About Evolution

Matters Microbial

Play Episode Listen Later Jun 17, 2026 65:01


Matters Microbial #132: What 83,000 Generations of Bacteria Reveal About Evolution June 17, 2026 Today Dr. Jeffrey Barrick, John A. Hannah Distinguished Professor of the Department of Microbiology, Genetics, & Immunology and the Department of Entomology at Michigan State University, joins the quality quorum today to discuss how microbes can be used to study evolution itself. He will also discuss the impressive and ongoing LTEE program, the experiments that originate from it, and what they tell us about evolution. Host: Mark O. Martin Guest: Jeffrey Barrick Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode Here is a link to an article about the late great Abigail Salyers. Here is what I wrote about Dr. Salyers. I learned so much from her.  An article about the contributions of Dr. Theodosius Dobzhansky to the study of evolution. The concept of contingency during evolution. An overview of microbial evolution. A link to "Microbes and Evolution," a book discussed during this podcast. A link to "A Primer for Experimental Evolution," a book discussed during this podcast. The concept of Growth Advantage in Stationary Phase (GASP). A video about the MEGA plate experiment by Dr. Michael Baym and colleagues. This is a "must watch." An video about Dr. Richard Lenski, originator of the LTEE. Dr. Lenski's website.  The LTEE (long term evolutionary experiment) website.  There is so much here to explore. An excellent introduction to the LTEE. An article about the amazing " climbing citrate mountain" innovation during LTEE described in the podcast. A video by Dr. Lenski about LTEE. A video by Dr. Barrick that is worth your time. Dr. Barrick's faculty website at Michigan State University. Dr. Barrick's research laboratory website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

The EMJ Podcast: Insights For Healthcare Professionals
AMJ Podcast | Episode 7: Inside SLE Immunology: Understanding Key Disease Pathways

The EMJ Podcast: Insights For Healthcare Professionals

Play Episode Listen Later Jun 17, 2026 28:03


This podcast has been funded by an educational grant from Viatris. Systemic lupus erythematosus (SLE) is a complex, heterogeneous disease shaped by dysregulated immune pathways, variable organ involvement, and substantial patient burden. In this educational podcast, Anca Askanase explores how a deeper understanding of SLE immunology can help rheumatologists contextualize disease activity, evolving research, and guideline-based care. Topics covered: Key immune pathways involved in SLE pathophysiology, including innate and adaptive immune dysregulation  How pathway biology may help explain clinical heterogeneity and differences in disease activity between patients  What rheumatologists should consider when interpreting emerging pathway-based research and cross-disease immunology concepts  How current guideline-based care frames treatment goals, patient burden, and the evolving focus on remission in SLE  Speakers Anca D. Askanase, Chair, Department of Medicine, and Chief, Division of Rheumatology, Hospital for Special Surgery, New York, USA

TheOccultRejects
The Mechanics of Magick: Meditation and the Ritual Engineering of the Self

TheOccultRejects

Play Episode Listen Later Jun 15, 2026 88:37 Transcription Available


If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBiblioBernardi, Luciano, Peter Sleight, Gabriele Bandinelli, Simone Cencetti, Luciano Fattorini, Johanna Wdowczyc-Szulc, and Alfonso Lagi. “Effect of Rosary Prayer and Yoga Mantras on Autonomic Cardiovascular Rhythms: Comparative Study.” BMJ 323, no. 7327 (2001): 1446–1449.Benson, Herbert, John W. Lehmann, Mark S. Malhotra, Ralph F. Goldman, Jeffrey Hopkins, and Mark D. Epstein. “Body Temperature Changes During the Practice of g Tum-mo Yoga.” Nature 295 (1982): 234–236.Benson, Herbert, Mark S. Malhotra, Ralph F. Goldman, Gregory D. Jacobs, and Jeffrey Hopkins. “Three Case Reports of the Metabolic and Electroencephalographic Changes During Advanced Buddhist Meditation Techniques.” Behavioral Medicine 16, no. 2 (1990): 90–95.Bremer, Brandon, Lorenzo Wu, Zoran Josipovic, and colleagues. “Mindfulness Meditation Increases Default Mode, Salience, and Central Executive Network Connectivity.” Scientific Reports 12 (2022).Brewer, Judson A., Patrick D. Worhunsky, Jeremy R. Gray, Yi-Yuan Tang, Jochen Weber, and Hedy Kober. “Meditation Experience Is Associated with Differences in Default Mode Network Activity and Connectivity.” Proceedings of the National Academy of Sciences 108, no. 50 (2011): 20254–20259.Britton, Willoughby B. and colleagues. Research associated with the “Varieties of Contemplative Experience” project on meditation-related challenges, adverse effects, and safety considerations in contemplative practice.Crowley, Aleister. Liber E vel Exercitiorum sub figura IX. In the A∴A∴ training corpus. Relevant sections include asana, pranayama, and dharana as foundational magical exercises.Dennison, Paul. “Insights From an EEG Study of Buddhist Jhāna Meditation.” Frontiers in Human Neuroscience 13 (2019).Fialoke, Shantala, Helen Weng, and colleagues. “Functional Connectivity Changes in Meditators and Novices During Yoga Nidra Practice.” Scientific Reports 14 (2024).Fox, Kieran C. R., Savannah Nijeboer, Matthew L. Dixon, James L. Floman, Melissa Ellamil, Samuel P. Rumak, Peter Sedlmeier, and Kalina Christoff. “Is Meditation Associated with Altered Brain Structure? A Systematic Review and Meta-analysis of Morphometric Neuroimaging in Meditation Practitioners.” Neuroscience & Biobehavioral Reviews 43 (2014): 48–73.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43.Kozhevnikov, Maria, Olesya Louchakova, Zoran Josipovic, and Michael A. Motes. “The Enhancement of Visuospatial Processing Efficiency Through Buddhist Deity Meditation.” Psychological Science 20, no. 5 (2009): 645–653.Kozhevnikov, Maria, John A. Elliott, Jennifer Shephard, and Klaus Gramann. “Neurocognitive and Somatic Components of Temperature Increases During g-Tummo Meditation: Legend and Reality.” PLOS ONE 8, no. 3 (2013): e58244.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217.Lomas, Tim, Juan Carlos Ivtzan, and Itai K. Fu. “A Systematic Review of the Neurophysiology of Mindfulness on EEG Oscillations.” Neuroscience & Biobehavioral Reviews 57 (2015): 401–410.Lott, James P., Richard J. Davidson, John D. Dunne, Thupten Jinpa, Antoine Lutz, and colleagues. “No Detectable Electroencephalographic Activity After Clinical Declaration of Death Among Tibetan Buddhist Meditators in Apparent Tukdam.” Frontiers in Psychology 11 (2021): 599190.Lutz, Antoine, Lawrence L. Greischar, Nancy B. Rawlings, Matthieu Ricard, and Richard J. Davidson. “Long-term Meditators Self-induce High-amplitude Gamma Synchrony During Mental Practice.” Proceedings of the National Academy of Sciences 101, no. 46 (2004): 16369–16373.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLoS ONE 3, no. 3 (2008): e1897.Matko, Karin, Peter Sedlmeier, and colleagues. “Adverse Effects of Meditation and Mindfulness in Clinical Practice.” 2025.Patanjali. Yoga Sutras. Especially Book III, traditionally describing dharana, dhyana, and samadhi.Riegner, Gretchen, Fadel Zeidan, and colleagues. “Disentangling Self from Pain: Mindfulness Meditation-Induced Pain Relief Is Driven by Thalamic-Default Mode Network Decoupling.” Pain 164, no. 2 (2023): 280–291.Tang, Yi-Yuan, Britta K. Hölzel, and Michael I. Posner. “The Neuroscience of Mindfulness Meditation.” Nature Reviews Neuroscience 16 (2015): 213–225.Vago, David R., and David A. Silbersweig. “Self-awareness, Self-regulation, and Self-transcendence: A Framework for Understanding the Neurobiological Mechanisms of Mindfulness.” Frontiers in Human Neuroscience 6 (2012): 296.Zeidan, Fadel, and colleagues. Research on mindfulness meditation, pain modulation, attention, and the neural mechanisms of pain relief.Slagter, Heleen A., Antoine Lutz, Lawrence L. Greischar, Andrew D. Francis, Sander Nieuwenhuis, James M. Davis, and Richard J. Davidson. “Mental Training Affects Distribution of Limited Brain Resources.” PLOS Biology 5, no. 6 (2007): e138. Use for: Attentional blink, limited attention, and meditation changing how the brain allocates resources.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43. Use for: Neuroplasticity, repeated practice leaving measurable marks on the brain, and the “practice writes itself into the practitioner” idea.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217. Use for: Predictive processing, the brain as a prediction machine, meditation loosening automatic models, and the “veil” argument.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLOS ONE 3, no. 3 (2008): e1897. Use for: Compassion meditation, loving-kindness, emotional circuitry, and training compassion as a repeatable state rather than just a moral idea.Kok, Bethany E., Kimberly A. Coffey, Michael A. Cohn, Lahnna I. Catalino, Tanya Vacharkulksemsuk, Sara B. Algoe, Marc A. Brantley, and Barbara L. Fredrickson. “How Positive Emotions Build Physical Health: Perceived Positive Social Connections Account for the Upward Spiral Between Positive Emotions and Vagal Tone.” Psychological Science 24, no. 7 (2013): 1123–1132. Use for: Loving-kindness, social connection, vagal tone, and the cautious “social nervous system” bridge.Black, David S., and George M. Slavich. “Mindfulness Meditation and the Immune System: A Systematic Review of Randomized Controlled Trials.” Annals of the New York Academy of Sciences 1373, no. 1 (2016): 13–24. Use for: Immune-system caution, inflammation markers, cell-mediated immunity, biological aging, and why this material should be framed as tentative rather than miracle healing.Burić, Ivana, Miguel Farias, Jonathan Jong, Christopher Mee, and Inti A. Brazil. “What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices.” Frontiers in Immunology 8 (2017): 670. Use for: Stress biology, inflammatory gene expression, NF-kB-related language, and the cautious claim that mind-body practices may affect biology below ordinary mood.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Time to Transform with Dr Deepa Grandon
What You Need to Know About Vaccine Hesitancy, Allergies, and Misinformation w/ Dr. Joyce Yu | Ep 56

Time to Transform with Dr Deepa Grandon

Play Episode Listen Later Jun 11, 2026 50:18


Why are more people becoming afraid of vaccines than the diseases vaccines were created to prevent? The answer is not simply a lack of information. In many ways, vaccines have become victims of their own success.For decades, widespread vaccination helped push diseases like measles, polio, pertussis, and smallpox out of everyday life. Many of us no longer live with the visible fear of these infections, their complications, or the way they can destabilize families, communities, and healthcare systems.But when the disease feels distant, the vaccine can start to feel like the bigger threat.That shift is now changing public health.Rather than assuming vaccine hesitancy is only about ignorance or defiance, we need to look more carefully at:• why people can become more suspicious of vaccines when they no longer see the diseases vaccines helped control• How misinformation, fear, personal experience, politics, history, and social media can shape health decisions• Why highly educated people can still be vulnerable to vaccine misinformation• how confusing a side effect, adverse event, or normal immune response with a true allergy can create long-term fear• Why egg allergy is no longer the vaccine barrier many people still believe it is• And how declining vaccination rates can allow diseases like measles and pertussis to reemergeVaccine education has to move beyond simply telling people what to do. We need clearer, more compassionate conversations that acknowledge fear while helping people separate facts from fiction.In this upcoming episode, I'm joined by Dr. Joyce Yu, associate professor of pediatrics and director of the Food Allergy Program at Columbia University Irving Medical Center.Together, we explore:What is driving the rise of vaccine hesitancyWhy vaccine-preventable diseases can return when communities let their guard downHow allergists help patients understand whether a vaccine reaction is truly an allergyAnd why rebuilding trust requires listening, clarity, and evidence-based conversationIf you or someone you love has ever felt uncertain, afraid, or confused about vaccines, allergic reactions, side effects, or conflicting health information, this conversation offers a grounded look at how fear spreads, how misinformation takes hold, and why protecting public health depends on rebuilding trust.Guest BioDr. Joyce Yu is an associate professor of pediatrics and director of the Food Allergy Program at Columbia University Irving Medical Center. She is an allergy and immunology specialist with clinical and scientific expertise in food allergy, immunology, vaccine-related concerns, and immune system function. Dr. Yu received her medical education at the Icahn School of Medicine at Mount Sinai, completed her residency at Northwestern/Lurie Children's Hospital, and completed her fellowship in Allergy and Immunology at Mount Sinai. Her postdoctoral work focused on toll-like receptor signaling and memory B cell development, mechanisms that are closely connected to how the immune system develops lasting protection. She is a fellow of both the American College of Allergy, Asthma & Immunology and the American Academy of Allergy, Asthma & Immunology. She is also a former president of the New York Allergy and Asthma Society and has held leadership roles within the Clinical Immunology Society. Connect with Dr. Yu on LinkedIn.About Your HostHosted by Dr. Deepa Grandon, MD, MBA, a triple board-certified physician with over 23 years of experience working as a Physician Consultant for influential organizations worldwide. Dr. Grandon is the founder of Transformational Life Consulting (TLC) and an outspoken faith-based leader in evidence-based lifestyle medicine.Disclaimer ​​TLC is presenting this podcast as a form of information sharing only. It is not medical advice or intended to replace the judgment of a licensed physician. TLC is not responsible for any claims related to procedures, professionals, products, or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services, or methods that might be referenced.Work With Me Learn More About My Soon-to-Launch Telemedicine PlatformExciting news. My virtual medical platform is launching soon! If you're looking for personalized, evidence-based care in allergy, immunology, and lifestyle medicine, stay tuned.Visit drdeepa-tlc.org and click on “Learn More” to join the waitlist and be the first to receive updates about services, membership options, and launch details.Precision care. Personalized guidance. Wherever you are.DevotionalsWant to receive a devotional every week from Dr. Deepa? Devotionals are dedicated to providing you with a moment of reflection, inspiration, and spiritual growth each week, delivered right to your inbox. Visit drdeepa-tlc.org to subscribe for free.Trauma CoursesReady to deepen your understanding of trauma and kick-start your healing journey? Explore a range of online and onsite courses designed to equip you with practical and affordable tools. From counselors, ministry leaders, and educators to couples, parents, and individuals seeking help for themselves, there's a powerful course for everyone. Browse all the courses now to start your journey.

Immune
Immune Booster 30: Infant Immunology with Martha Alexander-Miller

Immune

Play Episode Listen Later Jun 9, 2026 49:16


Martha Alexander-Miller discusses why newborn and infant immune responses to vaccines are generally less effective and how we can make vaccines safer and more effective. Host: Cindy Leifer Guest: Martha Alexander-Miller Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Flu HA nanoparticle vaccine (Nat Comm, 2025) Sex-dependent adjuvant activity in newborns (Vaccines, 2024) Flu vaccine with R848 adjuvant (Vaccines, 2023) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.  

Hope and Help For Fatigue & Chronic Illness
EP92: The Neuroimmune Impact of Environmental Exposure with Dr. Kiran C. Patel

Hope and Help For Fatigue & Chronic Illness

Play Episode Listen Later Jun 9, 2026 39:41


Support the Institute today. https://givenow.nova.edu/the-institute-for-neuro-immune-medicine-inim-2025   In today's episode, Haylie Pomroy is joined by Dr. Theoharis Theoharides, one of the world's leading authorities on mast cell biology and neuroimmunology, to reframe multiple chemical sensitivity as a measurable, physiological immune response rooted in mast cell activation. Dr. Theoharides explains how mast cells throughout the body and brain respond to environmental chemicals, stress hormones, fragrances, mold toxins, and other triggers by releasing hundreds of chemical mediators that can affect every organ system simultaneously. He outlines the specific labs and biomarkers worth requesting, why standard diagnostic pathways frequently miss this condition, and what patients can do right now to reduce mast cell reactivity through natural compounds, environmental modifications, and targeted testing. This is a conversation that gives patients the clinical language and tools they need to stop being dismissed and start getting answers. Tune in to Hope and Help For Fatigue and Chronic Illness. Dr. Theoharis Theoharides is a Professor, Vice Chair of Clinical Immunology, and Director at the Institute for Neuro-Immune Medicine-Clearwater, an Adjunct Professor of Immunology at Tufts School of Medicine, where he was a Professor of Pharmacology and Internal Medicine, and also the  Director of Molecular Immunopharmacology & Drug Discovery, and Clinical Pharmacologist at the Massachusetts Drug Formulary Commission (1983-2022). He received his BA, MS, MPhil, PhD, and MD degrees and the Winternitz Price in Pathology from Yale University and received a Certificate in Global Leadership from Tufts Fletcher School of Law and Diplomacy and a Fellowship at Harvard Kennedy  School of Government. He trained in internal medicine at New England Medical Center, which awarded him the Oliver Smith Award, "recognizing excellence, compassion, and service." Dr. Theoharides has 485 publications (46,491 citations; h-index 106), placing him in the world's top 2% of most cited authors, and he was rated the worldwide expert on mast cells by Expertscape. He was inducted into the Alpha Omega Alpha National Medical Honor Society, the Rare Diseases Hall of Fame, and the World Academy of Sciences.   Website: https://www.drtheoharides.com LinkedIn: linkedin.com/in/theoharis-theoharides-ms-phd-md-faaaai-67123735 Instagram: https://www.instagram.com/dr.theoharides/   Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.   Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com   Instagram: https://www.instagram.com/hayliepomroy  Facebook: https://www.facebook.com/hayliepomroy  YouTube: https://www.youtube.com/@hayliepomroy/videos  LinkedIn: https://www.linkedin.com/in/hayliepomroy/  X: https://x.com/hayliepomroy    Thank you for tuning in to the Hope and Help For Fatigue and Chronic Illness Podcast. Sign up today for our newsletter.

The Itch: Allergies, Asthma & Immunology
#160 - Meet the President of the AAAAI, Dr. Carla Davis

The Itch: Allergies, Asthma & Immunology

Play Episode Listen Later Jun 9, 2026 33:56


We are continuing our series of interviewing thought leaders in the field of allergy and immunology. Dr. Gupta and Kortney sit down with Dr. Carla Davis, the president of the American Academy of Allergy, Asthma and Immunology. What we cover in this episode about Dr. Davis and the AAAAI What the AAAAI is and why it matters to patients. A 7,000-member organization working behind the scenes to support allergy and immunology care across the US and around the world. Dr. Davis's path to the presidency. From her early experiences advocating as a fellow to her major pivot from Baylor to Howard University, the journey that shaped her priorities. Initiative: AAAAI Advocate. A new platform connecting patients and physicians directly to their legislators, making it easy to share your story and push for better access to allergy care. Initiative: AAAAI AI Task Force. A dedicated group bringing AI tools into allergy care, including AAAAI Ignite, a Netflix-style platform that helps members find and curate personalized allergy content. Initiative: The Collaborative Translational Mechanistic Research Seed Award. A $100,000 grant pairing laboratory scientists with clinical allergists to move new discoveries directly into patient care. More resources American Academy of Allergy, Asthma and Immunology AAAAI Advocate platform Allergy & Asthma Network health equity resources   This podcast is made in partnership with the Allergy & Asthma Network.  

The Smart 7
The Sunday 7 - Get set for a Summer of Heatwaves, the Pope intervenes on AI and why everyone hates the Electric Ferrari

The Smart 7

Play Episode Listen Later May 31, 2026 21:16


The Smart 7 is an award winning daily podcast, in association with METRO that gives you everything you need to know in 7 minutes, at 7am, 7 days a week...With over 20 million downloads and consistently charting, including as No. 1 News Podcast on Spotify, we're a trusted source for people every day and the Sunday 7 won a Gold Award as “Best Conversation Starter” in the International Signal Podcast Awards If you're enjoying it, please follow, share, or even post a review, it all helps...Today's episode includes the following guests:Clair Barnes - Research Associate in Extreme Weather and Climate at Imperial College LondonWendel Trio - Director of the Climate Action Network EuropeGary Clarke - Deputy Chair of the Construction Industry Council's Climate Change CommitteeWill Guyatt - The Smart 7's Tech Guru Pope Leo XIV - Leader of the Catholic Church Christopher Olah - Co-Founder of Anthropic Stephen Spielberg - Academy Award winning Director Dr Diana Atwine - Permanent Secretary at Uganda's Health MinistryTeresa Lambe - Professor of Vaccinology and Immunology at the University of OxfordMax Martin - Co-Founder and CEO of the Enhanced Games Jared Isaacman - NASA Administrator Carlos Garcia Galan - Programme Executive for NASA's Moon BasePatrick Nasbimana - Country Co-ordinator for the African Wildlife FoundationJames Munyawera - Lab Specialist at the Diane Fossey Gorilla FundContact us over @TheSmart7pod or visit www.thesmart7.com or find out more at www.metro.co.uk Presented by Ciara Revins, written by Liam Thompson, researched by Lucie Lewis and produced by Daft Doris. Hosted on Acast. See acast.com/privacy for more information.

A Conversation in Veterinary Pathology - The A.C.V.P. Podcast
S4E1 - A Conversation with Dr. Francisco Uzal

A Conversation in Veterinary Pathology - The A.C.V.P. Podcast

Play Episode Listen Later May 29, 2026 22:00


In this episode, we are joined by Dr. Francisco Uzal, an internationally recognized veterinary pathologist and a global leader in pathology education. He is a professor in Pathology, Microbiology, and Immunology at the University of California, Davis, and Branch Chief at the California Animal Health and Food Safety Diagnostic Lab. Dr. Uzal has spent more than four decades in academic diagnostic pathology and is the CEO of the Davis Thompson Foundation, the world's largest organization dedicated to teaching veterinary and comparative pathology.  Join us as we learn more about Dr. Uzal's career, shaped by international collaboration, mentorship, and service. He is especially known for his work in diagnostic pathology and clostridial diseases, as well as for expanding access to education. Most importantly, Dr. Uzal is a passionate educator and advocate for the global pathology community, and we're thrilled to have him with us today. So stay right here for our conversation with Dr. Francisco Uzal.  ____ Links ACVP Errors in Publication Portal 2026 ACVP Annual Meeting  ____ ACVP Social Media Facebook - ACVP Meetings and Topics Instagram - americancollegevetpath X (Twitter) - @ACVP LinkedIn - AMERICAN COLLEGE OF VETERINARY PATHOLOGISTS ____ Music: Guestlist by Podington Bear, licensed under an Attribution-NonCommercial 3.0 International License.  The contents of this audio do not necessarily reflect the opinions of the American College of Veterinary Pathologists (ACVP) or the participants' affiliations. Spoken audio content and associated photos are the property of the American College of Veterinary Pathologists, 2026. 

Time to Transform with Dr Deepa Grandon
Surgery vs. Biologics for Nasal Polyps: What Doctors Know Now w/ Dr. Tassos Hantzakos & Dr. Dipa Sheth

Time to Transform with Dr Deepa Grandon

Play Episode Listen Later May 28, 2026 56:19


When it comes to treating chronic sinus disease with nasal polyps…what's the best approach, surgery or biologics?Well, the answer is it's usually not either-or anymore.When patients are trying to manage these challenging conditions, some people opt for one or the other. But more physicians are finding that surgery and biologics aren't different paths. They are actually treatment protocols that complement each other.Surgery may remove the growths, but it doesn't necessarily stop the process of creating them in the first place. Biologics may suppress the inflammatory pathways driving recurrence, but they don't physically restore blocked sinus anatomy or remove bulky disease.We're entering a new phase of care where the question is no longer “surgery or biologics?” but how both can work together as part of a personalized strategy.Instead of treating every patient the same way, physicians are now looking deeper at the inflammatory pathways driving disease, recurrence risk, quality of life, and even how different biologics target different parts of the immune cascade.The shift is moving chronic sinus care away from a one-size-fits-all model and toward precision medicine that's designed around the individual patient.In this episode, I'm joined by Dr. Tassos Hantzakos, staff physician in otolaryngology and residency program director at Cleveland Clinic Abu Dhabi, and Dr. Deepa Sheth, allergy and immunology specialist.Together, we break down how the treatment landscape for chronic rhinosinusitis with nasal polyps is evolving, why collaboration between ENT and allergy specialists is becoming essential, and how biologics are reshaping the future of inflammatory airway disease management.Things You'll Learn In This Episode Not just a surgical problemFor decades, treatment focused on physically removing nasal polyps, but many patients still experienced recurrence. Why does surgery alone often fail to stop the disease?Biologics are changing how we think about airway diseaseNew biologic therapies are targeting different parts of the inflammatory cascade. How do physicians decide which biologic is the best fit for a specific patient?The future of treatment is collaborative, not competitiveThe conversation is shifting away from “surgery versus biologics” toward integrated care between ENT surgeons and allergists. When should surgery come first, and when should biologics be introduced?Precision medicine is reshaping chronic inflammatory careDifferent patients may require different treatment approaches. How does identifying the root inflammatory driver completely change long-term management outcomes?Guest BioDr. Tassos Hantzakos is a staff physician in the Otolaryngology Department at Cleveland Clinic Abu Dhabi's Integrated Surgical Institute, where he also serves as Program Director of the Otolaryngology Residency. His clinical expertise spans otolaryngology, rhinology, phonosurgery, laryngeal laser surgery, and voice disorders. Before joining Cleveland Clinic Abu Dhabi, Dr. Hantzakos served as a consultant within the Hellenic National Health System, Director of the Voice Clinic at NUKA, and Clinical Associate Professor at Cleveland Clinic Lerner College of Medicine in the US. He has contributed to numerous international journal articles and textbooks and is actively involved in several professional societies, including the European Laryngological Society, the International Association of Phonosurgeons, the Voice Foundation, and the European Society for Swallowing Disorders. Outside of medicine, he enjoys spending time with his family, long-distance running, triathlons, and playing guitar and drums. Connect with him on LinkedIn. Dr. Dipa K. Sheth is an allergist-immunologist based in Washington, DC, and an Assistant Professor of Medicine at Uniformed Services University of the Health Sciences. Her clinical work focuses on allergy and immunology, with experience treating conditions such as chronic sinusitis, rhinitis, atopic dermatitis, drug hypersensitivity, and food hypersensitivity. Dr. Sheth received her medical degree and completed her internal medicine training at George Washington University, followed by a fellowship in Allergy and Immunology at the University of Colorado School of Medicine and National Jewish Health. Her research has been published in journals including Frontiers in Allergy and Current Opinion in Allergy and Clinical Immunology. Connect with her on LinkedIn. About Your HostHosted by Dr. Deepa Grandon, MD, MBA, a triple board-certified physician with over 23 years of experience working as a Physician Consultant for influential organizations worldwide. Dr. Grandon is the founder of Transformational Life Consulting (TLC) and an outspoken faith-based leader in evidence-based lifestyle medicine.Disclaimer ​​TLC is presenting this podcast as a form of information sharing only. It is not medical advice or intended to replace the judgment of a licensed physician. TLC is not responsible for any claims related to procedures, professionals, products, or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services, or methods that might be referenced.Work With Me Learn More About My Soon-to-Launch Telemedicine PlatformExciting news. My virtual medical platform is launching soon! If you're looking for personalized, evidence-based care in allergy, immunology, and lifestyle medicine, stay tuned. Visit drdeepa-tlc.org and click on “Learn More” to join the waitlist and be the first to receive updates about services, membership options, and launch details.Precision care. Personalized guidance. Wherever you are.Devotionals Want to receive a devotional every week from Dr. Deepa? Devotionals are dedicated to providing you with a moment of reflection, inspiration, and spiritual growth each week, delivered right to your inbox. Visit drdeepa-tlc.org to subscribe for free.Trauma Courses Ready to deepen your understanding of trauma and kick-start your healing journey? Explore a range of online and onsite courses designed to equip you with practical and affordable tools. From counselors, ministry leaders, and educators to couples, parents, and individuals seeking help for themselves, there's a powerful course for everyone. Browse all the courses now to start your journey.

The Lab Report
Urolithin A with Dr. Anurag Singh

The Lab Report

Play Episode Listen Later May 22, 2026 33:52


Anurag Singh MD, PhD. is a physician, researcher, immunologist, and one of the leading voices behind the science of Urolithin A – a gut microbiome metabolite. Urolithin A is crucial for mitochondrial health by stimulating mitophagy. Dr. Singh breaks down the science and explains his extensive research into how this postbiotic compound could play a major role in cellular energy and longevity. Whether you’re an athlete, a health optimizer, or just curious about the future of longevity science, this conversation with Dr. Anurag Singh is packed with cutting-edge, evidence-based insights you won’t want to miss. Today on The Lab Report: 3:05 Meet Dr. Anurag Singh and learn about Urolithin A 6:45 Substrates, prevalence, and specific gut commensal bacteria 9:40 Mitophagy and mitochondrial health 12:55 Immunology and aging 15:35 Urolithin A and muscle mass 17:45 Academic research a-ha moments 20:15 Clinical benefits of Urolithin A 23:00 Food based approach vs. supplementation 25:25 Safety and contraindications 27:00 Ranking your supplement stack 29:10 The Fireball Additional Resources: Timeline Mitopure Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on X, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

The Preschool SLP
217. Do You Dare Disturb the Universe? The Asthma & Speech Sound Disorder Connection Nobody's Talking About

The Preschool SLP

Play Episode Listen Later May 21, 2026 29:36


You're welcome. Because today, we're digging into something I bet you're seeing on your back porch right now, and nobody is talking about it. Asthma and speech sound disorders. If you have a child on your caseload with significant asthma, this episode is the one you need tomorrow. Roll up your sleeves with me. We're going to get our hands really, really dirty, and we're going to talk about where the research stops and where the practitioner begins. Because this is where you have to have skin in the game. This is where it matters that you know your little professors closely, that you study what's happening under your own magnifying glass. Here's what we cover: What the research tells us. A Northwestern-led study of 337,285 children found that asthma, hay fever, and food allergy are significantly associated with speech disorders, and the more severe the disease, the greater the risk (Strom & Silverberg, 2016, Pediatric Allergy and Immunology). A 2006 population-based study of 7,389 eight-year-old children identified asthma as one of the factors associated with voice disorders (Carding et al., 2006, Journal of Voice). So we know there is a connection. And that is where the research stops. What I'm seeing on my back porch. This is where things get gnarly. The children with significant asthma are breaking the rules of speech development. They're stopping fricatives, they're fronting velars, they're voicing voiceless sounds, and they're deleting the /h/. Looks like phonological processes, right? Except phonological processes happen across positions of words. What I'm seeing with these kiddos is 0% accuracy in the initial position of words and 100% accuracy in the medial and final positions. That is not linguistic. Do you dare disturb the universe? Yes, you do. That's physiology. Why this is happening. My hypothesis, and this is practitioner experience, not research on large populations, is that these children have insufficient subglottal air pressure. Continuant sounds need continuous airflow from the respiratory system. After the vowel gets going, the vocal folds are doing the work and producing those sounds becomes easy. But in the initial position of words, when you're starting cold, you don't have that help. So fricatives stop, velars front, voiceless sounds get voiced, and the /h/ gets deleted. What the child is telling you. Mouth breathing at rest. Chin jutting. Head forward to get more air in. Tense neck and visible effort while speaking, like they're yelling at conversational volume. Fluctuating accuracy that tracks with allergy season and asthma flare-ups. The clear boogers come out and suddenly the phonological processes you thought were suppressed come right back. That is not a child regressing. That is a child without the respiratory support to do the work in initial position. What to do differently (DSD). You've been doing best practice. You're doing the complexity approach, you're doing DTTC, you're doing multimodal cueing, you're holding the 80% challenge point. And you're still at 0% in initial position. So we're going to do something different. We're going to capitalize on what the child can do. They can produce these sounds after a vowel, so we anchor with a vowel. We say "a sun, a sun." Or we use the end of one word to start the next, "yes sun, yes sun." And then over time, we stretch the pause longer and longer until that target is sitting in the initial position of the word on its own. That is how we DSD. This is one to take notes on. And if you have one of these kiddos on your back porch right now, shoot me an email. This is exactly the kind of clinical pattern I want to research next.

Let's Talk Wellness Now
Episode 265 – The Future of Healing: How Exosomes Re-Educate Your Body to Heal Itself

Let's Talk Wellness Now

Play Episode Listen Later May 20, 2026 51:27


Dr. Deb Muth 00:04What if the future of healing isn’t about replacing cells, but about teaching your body how to heal itself again? We keep hearing the words stem cells and exoomes thrown around like they’re interchangeable, but they’re not. One is regulated, controversial, and often misunderstood. The other is rapidly emerging as one of the most exciting communication systems in human biology. Dr. Deb Muth 00:33And here’s the real question no one’s asking. Are we actually regenerating tissue or are we just stimulating the body to remember how it used to heal? Tired of being told your labs are normal, but you still feel terrible? At Serenity Healthcare Center, we don’t chase symptoms. We find the root cause. hormones, gut health, autoimmune conditions, chronic fatigue, brain fog. Dr. Deb Muth 01:02We use cuttingedge functional and regenerative medicine to get you real answers and a real path forward. This isn’t your average doctor’s office. This is medicine the way it was meant to be practiced. You deserve to feel like yourself again. Visit serenityhealthcarecenter.com to book your appointment today. Let us help you heal from the inside out. Dr. Deb Muth 01:28Welcome back to Let’s Talk Wellness Now. I’m Dr. Deb, your host. And if you’ve been following regenerative medicine, you’ve probably noticed the confusion. Patients are asking me every week, are exoomes stem cells? Are stem cells legal in the United States? I heard the FDA is shutting down all these clinics. Can I even get this therapy? Do I have to leave the country for treatment? Today, we’re cutting through the noise. This episode is not hype. Dr. Deb Muth 01:54It’s not sales. It’s education so you can understand the science, the regulatory reality, and the clinical difference between stem cell therapy and exoome therapy. And here’s what I want you to know right up front. Yes, these therapies are being used in the United States every single day. Yes, they’re being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 02:22Some are being used in FDA registered clinical trials. Some are being used in observational studies and some are being used in clinical practice under physician discretion. The landscape is nuanced and you deserve to understand it. So, grab your cup of coffee or tea and settle in for a deep dive into the most understood therapies in regenerative medicine. Dr. Deb Muth 02:43what they actually are, how they work, the regulatory landscape, and how they might support your body’s natural healing capacity. Let’s talk wellness now. So, let me start by asking you something. When you hear the word stem cell, what do you picture? Most people imagine damaged tissues magically regenerating or a torn meniscus growing back, cartilage reforming it into an arthritic joint or damaged brain tissue being replaced with healthy new beautiful cells. It’s a beautiful vision. Dr. Deb Muth 03:15And while it’s not quite that simple, the reality is actually more sophisticated and honestly more beautiful. Stem cells are powerful and they absolutely work, but the way they work and the mechanism by which they support healing is far more elegant and more so than most people really understand. And if you’re going to invest in regenerative therapy, you deserve to understand what you’re actually receiving. Dr. Deb Muth 03:44So, let’s start at the beginning. What are stem cells? At their core, stem cells are undifferentiated cells. That means they haven’t yet decided what they want to be when they grow up. Unlike a heart cell or a skin cell or a bone cell which have already committed to a specific function, stem cells exist in this beautiful state of potential. Dr. Deb Muth 04:05They have two remarkable abilities. First, they can self-renew. They can make copies of themselves, maintaining a reserve of these powerful cells throughout your lifetime. Second, they can differentiate under the right conditions. They can transform into specialized cell types. Bone cells, cartilage cells, nerve cells, muscle cells, even blood cells. Dr. Deb Muth 04:27This is why they’ve captured the imagination of the medical world. The potential is extraordinary. Now, there are several types of stem cells and understanding the differences matters tremendously for both understanding how they work and understanding how they’re regulated. Adult mezzenymal stem cells. We call these MSC’s are the most commonly used regenerative medicine. Dr. Deb Muth 04:54These come from bone marrow, atapost tissue, that’s fat, and other adult sources. They’re what we can call multi-potent, meaning they can become several types of cells, but not every type. A bone marrow stem cell isn’t going to become a brain cell, for instance. It has potential but it’s directed potential. Dr. Deb Muth 05:19Then we have perinatal stem cells. These come from umbilical cord blood cord tissue or something called Wharton’s jelly which is the gelatinous substance inside the umbilical cord. These cells are younger, more potent, and research by Weiss and colleagues published in stem cells back in 2006 showed that Wharton’s jelly derived MSC’s have superior proliferation and differentiation potential compared to bone marrow derived cells. Dr. Deb Muth 05:48They’re like comparing a 20-year-old athlete to a 50-year-old athlete. Both can perform, but one has more reserve capacity, more vigor, and more regenerative potential. And this isn’t this is very important because the perinatal sources umbilical cord tissue Wharton’s jelly amniotic tissue these are what many regenerative medicine clinics in the United States are using today and they’re using them because these tissues are incredibly rich in not just stem cells but growth factors cytoines and exoomes. Dr. Deb Muth 06:21Then there are embryionic stem cells. These are pur potent and they become any cell type in the body, but they’re highly regulated, ethically controversial, and honestly, they’re not being used in clinical practice in the United States outside of the very specific FDA approved research trials. Dr. Deb Muth 06:41So, when clinics talk about stem cell therapy, they’re almost never talking about embryionic stem cells. Now, here’s where it gets interesting and this is the part that changes everything about how we understand regenerative medicine. When you receive stem cell therapy, let’s say someone injects umbilical cord derived messenymal stem cells into your arthritic knee, those cells do not typically engraft or become new tissue in any permanent way. Dr. Deb Muth 07:12They don’t set up shop in your joint and start cracking out new cartilage cells for the rest of your life. So what are they actually doing then? Well, in 2011, researchers Arnold Arnold Kaplan and Dennis Korea published a landmark paper in stem cells translational medicine that fundamentally changed how we understand MSC therapy. Dr. Deb Muth 07:35They proposed that we should stop calling memal stem cells and start calling them medicinal signaling cells. Why? Well, because their primary therapeutic benefit doesn’t come from what they become. It comes from what they secrete. Think of stem cells as incredibly sophisticated biological pharmacies. When you inject them into damaged tissue, that arthritic knee, that inflamed autoimmune condition, that injured brain, that don’t just sit there passively, they sense the environment. Dr. Deb Muth 08:07They detect inflammation. They recognize the tissue damage and they understand that the immune dysregulation is present and they see that and respond. They start pumping out hundreds of bioactive molecules, growth factors that tell your cells to repair and rebuild, cytoines that modulate inflammation, chemocines that recruit your body’s own healing cells to the area. Dr. Deb Muth 08:32And these tiny membranes bound packages called extracellular vesicles, including exosomes, which we’re going to talk about extensively today as well. These secreted factors are giving instructions to your native cells. They’re saying, “Let’s reduce inflammation. Let’s modulate your immune response. Let’s promote angioenesis. Dr. Deb Muth 08:53” That’s the formation of new blood vessels, bringing nutrients and oxygen. Let’s stimulate your own resident stem cells to wake up and get to work. Reduce cell death in damaged tissue and restore normal cellular function. This is called paracrine signaling. It’s the cellto cell communication. And this is where the real therapeutic power lives. Dr. Deb Muth 09:14The stem cells themselves, many of them die within days to weeks, but the cascade of healing they trigger, the signals they send, the programs they activate in your own cells, those effects can last for months or even years. Now, this understanding is crucial because it explains why both stem cell therapy and exoo therapy can be effective. Dr. Deb Muth 09:38The stem cells are powerful not because they become new tissue but because of the signals they send and exoomes are those signals isolated and concentrated. The biggest misconception in regenerative medicine is that stem cells replace tissue and in reality they coach healing more than they become healing. They’re biological educators teaching your body to remember how it used to heal before chronic inflammation, toxicity, and disease turned off all those programs. Dr. Deb Muth 10:12So if stem cells don’t exactly end graft and become the new tissue, if their power is in their signaling and then next logical question is why do we need the cells at all? Well, if we could isolate the messengers themselves, what if we could deliver just the communication systems without any of the complexity of the living cells? Well, that’s exactly what exosomes are. Dr. Deb Muth 10:38And they represent the cutting edge of regenerative medicine. So, let me paint you a picture of how cells actually communicate. Because for most medical history, we had it wrong. For decades, textbooks taught us that cells talk to each other in two basic ways. through direct contact like shaking hands or releasing signaling molecules that floated through the extracellular space like messages in bottles, simple chemical messages. Dr. Deb Muth 11:09But in the 1980s and 90s, researchers started discovering something far more sophisticated. cells were releasing these tiny membrane bound packages like a biological FedEx envelope kind of you know it was filled with complex specific cargo and these packages could travel through the blood cross the barriers that normally keep things out like bloodb brain barrier and deliver their contents to distant cells with remarkable precision. Dr. Deb Muth 11:38These are called extracellular vesicles. And exoomes are one of the most therapeutic important types. So what exactly are exosomes? Well, they’re nanosized vesicles, typically 30 to 150 nanome in diameter. To put that into perspective, a human hair is about 100,000 nanometers wide. These are incredible and most impossibly tiny. Dr. Deb Muth 12:09They’re released by virtually all cells in the body, but the most therapeutically interesting exoomes come from mezenymal stem cells. And those medicinal signaling cells we just discussed. And according to a landmark review of Raposo and Stervogal, they published in the journal of cell biology in 2013, exoomes are not cellular debris. They’re not waste products. Dr. Deb Muth 12:35They are precisely engineered communication vesicles or vehicles. Think of them as sophisticated delivery systems carefully packed, carefully labeled, and sent to specific destinations. very specific instructions. Inside each of these exoomes, you’ll find an incredibly sophisticated payload. They are microRNAs. These are small RNA molecules that can literally turn genes off or on in the recipient cells. Dr. Deb Muth 13:06They can tell a cell to start making more collagen, to reduce inflammatory proteins, to activate repair programs that have been shut down by chronic disease for a very long time. There are messenger RNAs, actual templates for protein production. And exoome can deliver these instructions for making healing proteins. There are proteins themselves, growth factors, cytoines, enzymes, all the molecular tools a cell needs to heal. Dr. Deb Muth 13:34And there are lipids, specialized fats that help the exoome membrane fuse with targeted cells, delivering the cargo inside. When an exoome reaches its target cell, it can either fuse the cell membrane and deliver its contents directly inside like a Trojan horse, or it can bind to surface receptors and trigger signaling cascades, setting off a chain reaction of healing responses. Dr. Deb Muth 14:01Either way, it’s delivering very specific targeted instruction. And here’s what makes this so powerful. Those instructions are tailored to what this recipient cell actually needs. So, let me give you some concrete examples of what the research actually shows because this is where it really gets exciting. When researchers inject MSC derived exoomes into hearts that had experienced eskeeia, reprofusion, injury, that’s damaged blood flow being cut off and then being restored. Dr. Deb Muth 14:36Kind of like what happens during a heart attack. Something remarkable happened. A study by Lei and colleagues published in stem cell research in 2010 showed that exoomes significantly reduced the size of the damaged area, reduced inflammatory cytoines that drive tissue destruction and promoted tissue repair signaling. The exoomes were telling the heart cells stop the inflammatory cascade, activate your survival programs and repair the damage. Dr. Deb Muth 15:06In cartilage research, tow and colleagues published work in biioaterials in 2017 showing that exosomes derived from MSC’s could promote cartilage regeneration in osteoarthritis models. And the exoomes carried specific microRNAs that told condondroytes cartilage cells to proliferate and make more extracellular matrix, the structural framework of healthy cartilage. Dr. Deb Muth 15:30for autoimmune conditions. Research by Blazic and colleagues in Frontiers in Immunology in 2014 demonstrated that MSC derived exoomes could shift immune cell behavior from pro pro-inflammatory to regulatory. They could take an overactive self-attacking immune system and restore balance and promote tolerance. And perhaps most exciting brain research, a study by Zinn and colleagues published in the journal of extracellular vesicles in 2013 showed that MSC derived exoomes could cross the bloodb brain barrier. Dr. Deb Muth 16:07That protective shield around your brain that normally keep things out and promote neurological recovery in stroke models. They reduced brain inflammation, promoted neuroplasticity, supported the formation of neural connections, and for mitochondrial dysfunction, which underlies so many chronic conditions, Morrison and colleagues published research and scientific reports in 2017 showing that MSC derived exoomes can actually deliver functional mitochondria or mitochondrial components to damaged cells. They’re not Dr. Deb Muth 16:40just sending instructions, they’re sending spare parts. They’re restoring the cellular powerhouses to produce energy. So why are exoomes fundamentally different from stem cells? Well, exoomes contain no living cells. They can’t replicate. They can’t end graph. And they have virtually no risk of immune rejection or tumor formation. Dr. Deb Muth 17:03Concerns that exist elevate rarely with cellular therapies. They’re essentially biological software updates for your cells. As Fineian Pitiger wrote in their seinal review in stem cells in 2017, MSC derived exoomes represent the active ingredient of stem cell therapy delivered in a cellfree format. That’s the key insight in the in the therapeutic benefit of stem cells and it comes from what they excrete. Dr. Deb Muth 17:33Then exoomes are the secretion isolated, concentrated, and standardized. From a practical clinical standpoint, exoomes offer several compelling advantages. First, consistency. Because exoomes can be isolated, characterized, and standardized, each dose can be remarkably consistent. With living stem cells, there’s variability based on donor age, health status, processing methods, and one batch may be robust, but another might be weaker. Dr. Deb Muth 18:05With exoomes, you can measure the content, measure the potency, and ensure the quality control. Second is storage. Exoomes can be liophalized. They can be freeze-dried and stored at room temperature or refrigerated for extended periods. Stem cells require cryopreserv preservation, careful freezing, careful thawing. They’re fragile. Dr. Deb Muth 18:31Exoomes are remarkably stable. And third, their safety profile. Without living cells, the risk of adverse imunological reactions is dramatically lower. You’re not introducing foreign cells that your immune system might recognize and attack. You’re introducing molecular messages. Fourth is scalability. You can harvest millions, even billions of exoomes from stem cell cultures without ever injecting the cells themselves. Dr. Deb Muth 19:01And you can produce large quantities, standardize them, and make them available to patients. Now, there is a caution here in doing this. The scalability can produce rogue cells, and we want to be cautious of that. So, here’s what I need you to understand. Exoomes don’t force healing. They remind the body how healing works. Dr. Deb Muth 19:24They’re not replacing damaged cells. They’re re-educating the cells you already have. They’re turning back time on the biological programs that got turned off by inflammation, toxicity, trauma, time, and chronic disease. Your body knows how to heal. It’s done its entire life. Every cut that closed, every bone that mended, every infection you fought off, your body orchestrated that healing. Dr. Deb Muth 19:51The problem is that chronic disease, chronic inflammation, toxic exposures, poor nutrition, stress, all of these things disrupt the communication networks that coordinate healing. And exoomes restore that communication. They’re like rebooting a computer that’s frozen. They reset the system and remind it how it’s supposed to function. All right. Dr. Deb Muth 20:14So, this would not be complete if we didn’t talk about regulation because this is where a lot of confusion exists. And I want you to be given a real picture. Not fear-mongering, not pretending. There aren’t regulatory considerations, but the actual practical reality of how regenerative medicine is practiced in the United States today. Dr. Deb Muth 20:38Here’s what you need to understand. The FDA regulates these therapies and they have specific frameworks, but there’s important nuances between regulatory text enforcement priorities and actual clinical practice. And there are also state level regulations that provide additional pathways. The FDA regulates human cells, tissues, and cellular and tissue based products. Dr. Deb Muth 21:05We call them HCT/PPS under two main pathways. Section 361 products are those that meet specific criteria. They’re minimally manipulated, intended for homologous use, meaning these tissues perform the same basic function in the recipient as it did in the donor. They’re not combined with non-tissue components and they’re either autotogus, meaning they come from your own tissue, or they have had minimal systemic effect. Dr. Deb Muth 21:38An example of a clear 361 procedure, your doctor harvests your own bone marrow, we call this PRP, performs minimally processing to or uh perform Yeah. performs minimal processing to concentrate the stem cells through a centriuge and injects it into your arthritic knee the same day. That’s autogus same day but minimally manipulated. Dr. Deb Muth 22:04This is unquestionably legal and is being done in regenerative medicine clinics across the country every single day. So there’s section 351 where products are those that don’t meet all the section 361 criteria. They’re classified as drugs or biologic products and they require FDA approval through clinical trials. Dr. Deb Muth 22:27Now here’s where this gets more nuanced. There are regenerative medicine clinics across the United States using stem cell and exoome therapies in different contexts. First FDA registered clinical trials. These are formal research studies with investigational new drug applications. Patients enroll in trials. They sign informed consents. Dr. Deb Muth 22:48They receive therapies as part of their structured research protocols. And this is completely legal and represents the gold standard for gathering evidence. Second is observational studies and registry programs. Many clinics are collecting systemic data on patient outcomes using these therapies even outside the FDA trials. Dr. Deb Muth 23:12They’re documenting results, tracking safety, and contributing to the growing body of clinical evidence. Third, there’s clinical practice under physician discretion. There are physicians using these therapies based on their own clinical judgment informed consent from patients and their interpretation of the regulatory framework particularly around minimal manipulation and homologous use. Dr. Deb Muth 23:34Now there are also state regulations that provide additional legal frameworks. So, for example, Florida has enacted the Right to Try Act and specific regenerative medicine legislation that allows physicians to offer certain stem cell therapies under the state oversight. Utah has passed similar legislation creating pathways for regenerative medicine products. Dr. Deb Muth 23:57And these state laws recognize that patients should have access to potentially beneficial therapies, particularly when used by trained physicians with appropriate informed consent. The regulatory question often centers around are these products minimally manipulated. Some products clearly are not. They’ve been cultured. Dr. Deb Muth 24:20They’ve been expanded in laboratories and those require FDA approval that they don’t have. The FDA has appropriately shut down clinics using those products. But there are other products that undergo processing that many physicians and manufacturers argue constitutes minimal manipulation. And these tissues are cleared, potentially fragmented or particulated to make them more suitable for injection, preserved using methods like cryopreservation or liophalization and packaged. Dr. Deb Muth 24:54But the cells are not cultured or expanded in the laboratory. The FDA has issued guidance suggesting that many of these processing steps constitute more than manipul minimal manipulation. But many physicians, particularly those who specialized in regenerative medicine for years, disagree with that interpretation and they believe that the processing qualifies as minimal manipulation and that the product should fall under section 361 when used for homologous purposes. Dr. Deb Muth 25:24Is there regulatory debate? Absolutely. The FDA and some clinicians have different interpretations of what constitutes minimal manipulation. But here’s the practical reality. There are hundreds of well-trained, bore certified physicians across the United States offering these therapies every single day. Dr. Deb Muth 25:42They’re doing so based on their understanding of the regulations, their clinical experience, their commitment to patient safety, and their belief that these therapies can help people who have exhausted conventional options. The FDA’s enforcement priorities have focused primarily on the most problematic cases. Clin clinics making blatant disease cure claims, products with documented safety issues, clear cases of cellular expansion and culture, or clinics operating with no medical oversight. Dr. Deb Muth 26:15Reputable regenerative medicine physicians are using products from companies that provide comprehensive documentation of their processing methods. third-party sterility testing, certificates of analysis showing bioactive content, and quality control measures that meet or exceed industry standards. Now, let me be very clear about something. Dr. Deb Muth 26:36Quality matters enormously. Not all stem cells and exoome products are created equal. Research by Burger and colleagues published in the Orthopedic Journal of Sports Medicine in 2021 analyzed 12 commercially available stem cell products and found that many contained zero viable cells, high levels of bacteria, endotoxins and inconsistent growth factor concentrations. Dr. Deb Muth 27:01This is why the company providing these biologic matters tremendously. You want products from manufacturers who provide transport documentation in sourcing and processing. Conduct third-party testing and sterility and potency. Offer certificates of analysis for each batch. Use standardized validated processing protocols. Dr. Deb Muth 27:24Have quality control measures that ensure consistency and don’t make outrageous cure claims or promise. The best regenerative medicine physician carefully vet their suppliers. They don’t use products from companies making unrealistic promises. They use products from manufacturers who are transparent, scientifically rigorous, and committed to quality. Dr. Deb Muth 27:46Now, you specifically ask about homologous use and collagen defects. So, let me address this directly for you. Under the FDA guidance, homologous use means the tissue performs the same basic function in the recipient as in the donor. So for connective tissue, tendons, ligaments, cartilage, fascia, all of that which are collagenrich structures using MSC’s or their derivatives could be considered homologous use. Dr. Deb Muth 28:17MSC’s in their native environment provide structural support to produce extracellular matrix including collagen. Using them to support healing in damaged collagen rich tissues like arthritic joints, torn tendons or degenerative ligaments is arguably the same basic function. So using exoomes derived from MSC’s to support collagen synthesis reduce inflammation and promote tissue healing in the same structures. Dr. Deb Muth 28:46Many practitioners argue this also qualifies as homologous use because you’re supporting the structure and function that MSC’s would naturally support. So here’s the bottom line on the regulatory reality. Regenerative medicine is available in the United States. It’s being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 29:11Some therapies are offered in FDA registered clinics and some are offered in observational studies. Some are offered in clinical practice under physician discretion, informed consent, and careful attention to safety. The regulatory landscape is evolving. There are ongoing discussions both federally and state levels about creating clearer pathways for these therapies. Dr. Deb Muth 29:32So, if you choose to go down this road, you want to work with physicians who understand the regulations, who use quality products from reputable manufacturers with rigorous testing and documentation, who are transparent about what they’re using and why, who discuss the current regulatory landscape honestly with you, and who prioritize your safety and truly informed consent above all else. Dr. Deb Muth 29:55This is not a lawless wild wild west. But it is also not as simple as everything is legal and unavailable. It’s a nuanced landscape that requires ethical knowledge. And these practitioners that have this knowledge have got to provide informed patients who understand both the potential benefits and the current regulatory context. Dr. Deb Muth 30:17So let’s have some fun here. Let’s talk about what really matters to you that are listening and that’s what conditions are being supported with these therapies. What does the research show and what are clinicians seeing in actual practice with patients? Because here’s what’s really important. We have both published research evidence and extensive clinical experience. Dr. Deb Muth 30:38And when the two align, that’s when we can feel confident and comfortable about using these approaches. So, let’s start where we have the most substantial evidence. joint health and muscularkeeletal conditions. For arthritis, we have good data. A systemic review by Tan and colleagues published in arthritis research and therapy in 2021 analyzed 20 randomized controlled trials in MSC therapy for knee osteoarthritis. Dr. Deb Muth 31:05They found significant improvements in pain and function particularly in mild to moderate disease. What’s really interesting is when researchers start analyzing whether it was the cells themselves or their secreted factors doing the work. They found that exoomeenriched preparations showed similar benefits to whole cell therapy. Dr. Deb Muth 31:26Now towen colleagues in the biioaterials paper from 2017 demonstrated that MSC derived exoomes could promote cartilage matrix synthesize and reduce inflammation markers. The exoomes carried microarnas that told cartilage cells to make more collagen and proteoglycans, the building blocks of healthy cartilage. Dr. Deb Muth 31:49In clinical practice, physicians are seeing patients with knee, hip, shoulder, and spinal arthritis, experiencing reduced pain, improved function, better motility, and in some cases, measurable improvements in their tissue. I want to share a story here with you because back in 2006, my husband was injured at work. Some of you might have heard me tell this story before. Dr. Deb Muth 32:11Um, he broke two discs in his back and underwent surgery very early on when we started using stem cells. They had put cages and plates in and they used MSC’s to put inside the cage to create a hardened bone so that he could have a fusion and hopefully not have any pain. At the time, what the physician didn’t realize or mistakenly did was he did not put any human bone mixed with these dead cadaavver bone MSC’s. Dr. Deb Muth 32:42And so the MSC’s never grew. They didn’t have anything to grow by. So the plates and the screws just kind of went back and forth for six months before he could see another physician that would look at him differently and understand what actually happened. That was very early on. Today we know so much more than we did before. Dr. Deb Muth 33:01Fast forward to 2014 when my husband was having problems and he couldn’t feel his legs, he couldn’t feel his feet. We decided to undergo uh exoo and stem cell therapy again and we saw a physician in Florida who harvested cells from his bone marrow and his blood and his fat and mixed that all together and then put that back into the back. Dr. Deb Muth 33:27and he had tremendous benefit from it. So, I tell this story because I want you to see the trajectory of how long this has been going on that we’ve been using this and we’re learning as we’re going and things are changing rapidly in this in this world. And so, what we know today and what I’m teaching you today may very well change in a month or six months or a year from now, but we have the foundation at least to understand what is helpful, what is not right now. Dr. Deb Muth 33:54But just be aware that if you’re embarking on exoome or stem cell therapy or MSC’s that you understand that this terrain is going to change. So back to my conversation about what other things can we treat? Well, we can treat tendon and ligament injuries, chronic tennis elbow, Achilles tendonopathy, rotator cuff tears, chronic planter fasciitis. Dr. Deb Muth 34:17These were researched by PA and colleagues in the American Journal of Sports Medicine in 2017 and it showed that bone marrow concentrate injections resulted in improved pain and function compared to steroid injections. Now this mechanism appears to be enhanced collagen remodeling and reduced chronic inflammation. Dr. Deb Muth 34:39These are structural collagenrich tissues using MSC’s or their derivatives for structural support which makes biological sense. It’s homologous use. It’s similar. So clinically we’re seeing athletes, active adults and people with chronic pain who failed physically um failed physical therapy, failed conservative treatments finding relief in this functional uh improvement in this functional world that we live in today. Dr. Deb Muth 35:07So, I want to be clear about what we’re doing here for joint and muscularkeeletal issues. We’re not growing completely new cartilage from scratch or severely destroyed joints. We’re not magically regenerating tissues that’s been gone for decades. That’s not possible here. What you’re doing when you’re using MSSE’s and exoomes is supporting the body’s natural ability to repair, reducing inflam inflammation and damage, and we’re driving progressive degeneration uh or we’re stopping the progressive degeneration. By reducing the Dr. Deb Muth 35:41inflammatory damage, we’re stimulating resonant stem cells that have been dormant. We’re improving blood flow and uh uh oxygen to the tissues like cartilage and tendons. and we’re organizing the body to start creating its own quality collagen as it heals. So, it’s a regenerative support, not a tissue replacement. Dr. Deb Muth 36:07But for many people, this support is lifechanging. So, let’s talk about autoimmune disorders now because this is one of the most exciting and unrecognized applications. autoimmune conditions like rheumatoid arthritis, lupus, MS, Crohn’s disease, ulcerative colitis, Hashimoto’s, they all involve the immune system and the immune system is deregulated. Dr. Deb Muth 36:30And so basically your immune system is seeing this tissue as foreign and it’s attacking it. These MSC’s and their exoomes have profound immune modulatory properties. They don’t suppress the immune system like steroids or imunosuppressive drugs. They modulate it helping to restore balance. So for rheumatoid arthritis, research by Weang and colleagues in stem cells translational medicine in 2016 showed that MSC derived exoomes could shift the balance of immune cells, reducing pro-inflammatory TH7 cells that drive joint disruption uh and increase Dr. Deb Muth 37:08regulatory TE-C cells that maintain immune tolerance. So for MS, a clinical trial by Kasus and colleagues published in archives of neurology back in 2010 evaluated autotogus MSC therapy and MS patients and they found evidence of reduced disease activity, improved neurological function and decreased inflammatory uh lesions on MRI scans. Dr. Deb Muth 37:34The proposed mechanism is MSC’s and their exoomes reduce inflammatory cytoine production promote regulatory imu immune populations support remination of damaged nerves that is rebuilding the protective coating around the nerve fibers and it reduces bloodb brain barrier permeability which prevents immune cells from attacking their brain and spinal cord. Dr. Deb Muth 38:02And so for inflammatory bowel disease, the research by Barnholm uh sorry Barnhorn and colleagues in gut in 2020 showed that MS cell MSC derived extracellular vesicles could support mucosal healing and reduce inflammation in the gut lining. They appeared to restore intestinal barrier function, healing that leaky gut and modulating local immune responses. Dr. Deb Muth 38:30So in clinical practice, physicians are seeing patients with autoimmune conditions, experiencing reduced disease flares, decreasing the need for imunosuppressive medications, improving energy and quality of life, and in some cases extending periods of remission. But here’s what I want you to understand. Dr. Deb Muth 38:52When you see these therapies for autoimmune conditions, we are supporting immune regulation and reducing inflammatory damage. We are not treating or curing the disease in a conventional sense. These therapies work best as part of a comprehensive functional medicine approach that also addresses gut health because 70% of your immune system lives in your gut and environmental triggers like mold, heavy metals, chemical toxins that can drive autoimmune responses, chronic infections that can trigger immune disregulation, stress and nervous system imbalance. And Dr. Deb Muth 39:29these nutritional deficiencies are necessary to help improve the immune function. So regenerative therapy without addressing root causes is like bailing water out of your boat without plugging the hole. You might get temporary relief, but the underlying problem still remains. So let’s talk about neurological conditions. Dr. Deb Muth 39:52And this is where the science gets truly fascinating. for traumatic brain injury and concussion. Research by Zang and colleagues in the Journal of Neurot Trauma in 2015 showed that MSC derived exoomes could reduce brain inflammation, promote neuroplasticity, that’s the brain’s ability to rewire itself and improve cognitive outcomes in animal models. Dr. Deb Muth 40:17The exoomes crossed the bloodb brain barrier, delivered neuroprotective proteins and microRNAs. They reduced inflammation, supported mitochondrial function in injured neurons and promoted both new blood vessels from new blood formation and neurogenesis and the birth of new neurons occurred. Neurological recovery requires a multi-systematic approach. Dr. Deb Muth 40:42Exoomes may support neural repair, but they work best combined with hormone optimization, growth hormone, testosterone, thyroid, pregnnolone, mitochondrial support compounds like NAD, CoQ10, PQQ, carnitine, all of those things that we use traditionally in functional medicine. Now for stroke recovery, there was research by Zinn and colleagues in the journal of extracellular vesicles that showed MSC derived exoomes reduced the size of brain damage and improved neurological recovery in animal models. There was a Dr. Deb Muth 41:19Parkinson’s disease study done by Kimoji and colleagues in the movement disorders in 2018 that suggested that MSSE derived exoomes could support dopamineergic neuron survival and those are the cells that die in Parkinson’s and it can help to reduce neuroinflammation. Clinically, physicians are seeing improvements in patients with postconussion syndrome, chronic traumatic brain injury, early stage cognitive decline, and other neurodeenerative conditions. Dr. Deb Muth 41:52These are not cures, but meaningful improvements in cognitive function, mood, energy, and quality of life. Now, let’s talk about autism spectrum disorder very carefully here because this is a very sensitive but very important topic for families. There have been several clinical trials that have explored MSC therapy for autism. Dr. Deb Muth 42:16Liv and colleagues published research in stem cell translational medicine in 2013 showing improvements in social interaction, communication, and behavioral symptoms in children with ASD who received cord blood MSC’s. Dawson and colleagues in 2017 conducted randomized trial autotogus cord blood infusion and found modest improvements in social communication particularly in children with higher baseline immune dysregulation. Dr. Deb Muth 42:47The proposed mechanisms for modulation of neuroinflammation support the mitochondrial function because many children with autism show evidence of mitochondrial dysfunction, reduction of oxidative stress, improvement in gut brain access dysfunction and modulation of immune dysregulation. In clinical practice, some physicians are seeing improvements in some children, better eye contact, increased language development, reduced sensory sensitivities, improved social engagement, but responses vary significantly, and we cannot predict which children will benefit most. So for Dr. Deb Muth 43:26families considering regenerative approaches for autism, these therapies are supporting the body’s healing mechanisms, reducing neuroinflammation, supporting cellular energy production, modulating immune function. These should only be considered as part of a comprehensive biomedical approach that includes dietary interventions to address food sensitivities, support gut health, environmental toxin removal, particularly heavy metals and chemical exposures, gut healing protocols with targeted probiotics and nutrients, Dr. Deb Muth 44:00metabolic testing and targeted supplementation, and evidence-based on behavioral and developmental therapies. These therapies should only be pursued with practitioners who are honest about what we know and what we don’t know and who follow rigorous safety protocols who never promise cures and who view regenerative medicine as a tool in the comprehensive healing strategy, not a standalone miracle. Dr. Deb Muth 44:26Not only that, these therapies will most likely need to be given several times over the course of this person’s lifetime, possibly even on an annual basis. And this is really important because it is not a oneandone. It is not a one-sizefits-all, and it needs to be looked at as a long-term option for working with autism. So, since we’re looking at stem cells versus exoomes, living cells, with stem cell therapy, you’re receiving living cells that can survive in your body for days to weeks. Dr. Deb Muth 45:02With exoome therapy, there are no living cells, just biological messages they would have sent. So, replication stem cells can potentially replicate. Although therapeutically this happens minimally, exoomes cannot replicate. They deliver the cargo and then they are cleared by your body. With stem cells, it’s primarily paracrine signaling. Dr. Deb Muth 45:28They’re coaching your cells to heal. With exoomes, it’s pure signaling, pure reprogramming your cells without any cellular component. Stem cells as we talked about can be autotogus from your own bone fat, blood or um bone marrow or allergenic from umbilical cord tissue or Wharton’s jelly. Dr. Deb Muth 45:50Exoomes are typically derived from cultured MSC’s often from umbilical cord or bone marrow sources and both can be given by local injection for targeted treatment of joints and tissues and exoomes can be given intravenously for whole body systemic support. both have um low immun immunogicity. I can’t say that word today. Dr. Deb Muth 46:17But exoomes have even lower risk since they contain no cellular material. Now, it’s absolutely critical for you to understand that there are massive quality differences. We’ve talked about this earlier. I want you to be very aware of this and have a conversation with any of the practitioners that you’re considering undergoing this treatment with. Dr. Deb Muth 46:37Here is where it matters more than anything when you’re considering regenerative medicine, the quality of the products and the expertise of the practitioner. Because the reality is not all regenerative medicine products are created equal. We all know that when we take different supplements and not all practitioners understand these therapies at the same depth. Dr. Deb Muth 46:58You want to look for practitioners that are board certified or have some kind of specialized regenerative medicine training. You want to know their clinical experience. How much have they done these procedures? How long have they done this? You want honest communication about the evidence and the limitations in this. Dr. Deb Muth 47:17You want a comprehensive functional medicine approach to go along with these therapies. And you want somebody that’s transparent about their informed consent and their regulatory status. If you have people that are uh claiming that they can cure disease or giving you guarantees, that is not that is not a good practitioner to work with. Dr. Deb Muth 47:37If you have high pressure sales tactics, you need to decide today limited supply for a week. These are marketing manipulations. It’s not medical care. You want to be cautious of extremely low prices because quality regenerative products are expensive to source, process, and test. and store. And if somebody’s offering stem cells or exoomes for a few hundred dollars, seriously, you need to question the quality, the safety, and where they got this from. Dr. Deb Muth 48:09So before undergoing any regenerative therapy, make sure you’re having a very, very lengthy conversation with the person and so you truly understand exactly what you’re getting, how it’s going to be delivered, and what they’re going to do. If there’s one thing I want you to take away from today is that your body has remarkable capacity to heal when given the right biological signals and the right environment. Dr. Deb Muth 48:35Stem cells and exoomes are powerful tools for providing biological signaling that can reduce inflammation, modulate immune function, support tissue repair, and restore cellular communication that’s been disrupted by chronic disease and inflammation. These therapies are available in the United States through trained physicians working in FDA registered trials, observational studies, and clinical practice, and using quality products from manufacturers with rigorous testing and quality control. Dr. Deb Muth 49:04So before you invest in regenerative medicine, do your homework. Ask detailed questions about product quality and source. Verify the products come from reputable manufacturers with certificates of analysis, third-party testing. Work with experienced practitioners. And remember, no injection, no infusion, no biologic can overcome ongoing toxic exposure, chronic stress, poor nutrition, gut dysfunction, and inadequate sleep. Dr. Deb Muth 49:34True healing requires your body and you to actively participate in this healing. If you are unwilling to address the root causes and change the lifestyle factors that disrupted your health in the first place, the biologics can amplify your healing signals, but you have to create the internal environment where healing can actually happen. Dr. Deb Muth 49:56So, I hope this episode has helped you understand regenerative medicine more clearly. Share it with somebody who’s looking for healing beyond the conventional approaches. And until next time, this has been Let’s Talk Wellness Now. Have a blessed day. >> Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Dr. Deb Muth 50:16Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided forformational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. Dr. Deb Muth 50:41While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Your use of information from this broadcast is entirely at your own risk. Dr. Deb Muth 51:00By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time, and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 265 – The Future of Healing: How Exosomes Re-Educate Your Body to Heal Itself first appeared on Let's Talk Wellness Now.

The OSA Insider
Episode 138: Student Engagement and Student Life with Dr. Tonya Webb

The OSA Insider

Play Episode Listen Later May 18, 2026 23:49


Dr. Tonya Webb is a Professor of Microbiology and Immunology whose scientific work focuses on cancer immunotherapy. She is also the Assistant Dean for Student Engagement and Student Life in our Office of Student Affairs. What does this particular role mean? How does her office engage medical students, and how does she know when an initiative or project is working when it comes to enhancing student life? In this episode, we'll get to know Dr. Webb, all the hats she wears, and how she approaches meeting, engaging with, and helping our students.   

ImmunoTea: Your Immunology Podcast
ImmunoTea Episode 41 - Systems Immunology

ImmunoTea: Your Immunology Podcast

Play Episode Listen Later May 17, 2026 40:09


On this episode Lara and Vyanka talk to Professor Petter Brodin from the Karolinska Institute all about understanding variation in human immune systems and how immune networks function in health and disease. This is ImmunoTea: Your Immunology Podcast, presented by Dr Lara Dungan and Dr Vyanka Redenbaugh. This is the show where we tell you all about the most exciting research going on in the world of immunology. So grab a cup of tea, sit down and relax and we'll fill you in. Contact us at ImmunoTeaPodcast@gmail.com or @ImmunoTea on twitter. Hosted on Acast. See acast.com/privacy for more information.

Biotech 2050 Podcast
Acadia CEO Catherine Owen Adams on Neurodegeneration, AI & Building Biotech Vision

Biotech 2050 Podcast

Play Episode Listen Later May 13, 2026 33:34


Synopsis: At the intersection of personal mission and biotech leadership, Rahul Chaturvedi sits down with Catherine Owen Adams, CEO of Acadia Pharmaceuticals, for a deeply personal and strategically rich conversation on leadership, commercialization, and the future of neuropsychiatry. From starting as a pharmacist in the UK to pivoting from R&D into commercial leadership at Johnson & Johnson, rising through Bristol Myers Squibb, and ultimately stepping into her first biotech CEO role at Acadia, Catherine shares how storytelling became the throughline of her career—transforming science into physician trust, investor conviction, and enterprise vision. In this episode, Catherine opens up about the personal family experiences with neurodegenerative disease that made Acadia's focus on CNS and rare disease feel like her “Goldilocks opportunity.” She offers a candid look at the realities of being a first-time CEO, managing investor ecosystems, building the right C-suite, balancing billion-dollar commercial execution with high-risk R&D, and navigating the emotional stakes of developing therapies for Parkinson's disease psychosis, Alzheimer's disease psychosis, Rett syndrome, and beyond. Rahul and Catherine also explore the seismic shifts reshaping biotech—from AI-powered commercialization and patient services to policy advocacy through BIO, FDA modernization, and the strategic pressures facing CNS innovation. This episode is both a masterclass in biotech leadership and a powerful reminder that the best CEOs don't just run companies—they tell stories that move science, markets, and patients forward. Biography: Ms. Owen Adams joined Acadia as Chief Executive Officer and as a member of our Board of Directors in September 2024. Ms. Owen Adams has over 25 years of executive level experience in the pharmaceutical industry. Prior to joining Acadia, Ms. Owen Adams served as Senior Vice President and General Manager, U.S., at Bristol Myers Squibb (BMS), where she led a $20 billion commercial business, overseeing a large and diverse portfolio of promoted brands across Oncology, Cardiovascular, and Immunology. Previously, Ms. Owen Adams held the position of Senior Vice President, Head of Major Markets at BMS, where she led commercial operations leading 6,000 employees across 19 countries in Europe, Japan, and Canada during BMS's merger with Celgene. Prior to her tenure at BMS, Ms. Owen Adams spent 25 years at Johnson & Johnson (J&J), where she held leadership roles across global, U.S., and European business units, with her last position being President, Janssen Immunology U.S. Ms. Owen Adams began her career in R&D and manufacturing at AstraZeneca. Ms. Owen Adams currently serves on the board of directors of Agios Pharmaceuticals, Inc., a publicly held company, and AssistRx, a privately held company. Ms. Owen Adams was formerly on the board of directors and chair of the compensation committee for Optinose PLC, a public specialty pharmaceutical company, and was on the board of directors of Robert Wood Johnson University Hospitals, a non-profit organization. Ms. Owen Adams earned a BSc. in Pharmacy from the University of Manchester, becoming a qualified pharmacist and member of the Royal Pharmaceutical Society (MRPhS).

FAACT's Roundtable
Ep. 281: Avoidant/Restrictive Food Intake Disorder (ARFID) & Food Allergies

FAACT's Roundtable

Play Episode Listen Later May 13, 2026 33:47 Transcription Available


Safe eating is at the heart of managing food allergies—but what happens when that vigilance starts to feel overwhelming, and food becomes a source of fear instead of nourishment? For many families, the line between necessary caution and something more serious can be hard to recognize. We are diving into the intersection of food allergies and Avoidant/Restrictive Food Intake Disorder, or ARFID. Joining us is Dr. Brian Vickery, Division Chief of Allergy & Immunology at Children's Healthcare of Atlanta and Emory University, and Kaitlin B. Proctor, PhD, Assistant Professor at Emory School of Medicine Department of Pediatrics, and board-certified psychologist at Children's Healthcare of Atlanta to unpack what this means for families and share insights from Dr. Vickery's latest research. Resources to keep you in the know:Psychology TodayAAAAI's People with Food Allergies May Be Susceptible to Avoidant/Restrictive Food Intake DisorderFAACT's Behavioral Health Resource Center"When Medically Required Food Avoidance Goes Awry: A Conceptual Framework of ARFID as an Underrecognized Clinical Complication of Food Allergy" - Research paperFAACT's Roundtable Podcast can be found on Apple Podcast, Pandora, Spotify, Podbay, iHeart Radio or wherever you listen to your podcasts.Follow us on Facebook, Instagram, Threads, BlueSky, LinkedIn, Pinterest, TikTok, and YouTube. Sponsored by: GenentechThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!

Connections with Evan Dawson
Rochester ranks high for allergies. What should we know about triggers and treatment?

Connections with Evan Dawson

Play Episode Listen Later May 7, 2026 51:16


Rochester was recently ranked the fifth worst American city for allergies. We sit down with members of the Golisano Children's Hospital Pediatric Allergy team to discuss how families can prepare for allergy season. They explain triggers, treatments, and how allergies affect children and schools. In studio: Jessica Stern, M.D., associate professor of allergy and immunology in the Department of Medicine, Division of Allergy/Immunology and Rheumatology; and the Department of Pediatrics, Division of Pediatric Allergy and Immunology at University of Rochester Medicine Katherine L. Tuttle, M.D., clinical director of the Department of Pediatric Allergy and Immunology, associate program director of the Allergy and Immunology Fellowship, and assistant professor of pediatrics and medicine at University of Rochester Medicine ---Connections is supported by listeners like you. Head to our donation page to become a WXXI member today, support the show, and help us close the gap created by the rescission of federal funding.---Connections airs every weekday from noon-2 p.m. Join the conversation with questions or comments by phone at 1-844-295-TALK (8255) or 585-263-9994, email, Facebook or Twitter. Connections is also livestreamed on the WXXI News YouTube channel each day. You can watch live or access previous episodes here.---Do you have a story that needs to be shared? Pitch your story to Connections.

The Zero to Finals Medical Revision Podcast
Complement Disorders (2nd edition)

The Zero to Finals Medical Revision Podcast

Play Episode Listen Later May 6, 2026 7:12


This episode covers complement disorders.Notes: https://zerotofinals.com/paediatrics/immunology/complementdisorders/Questions: https://members.zerotofinals.com/Books: https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

The Zero to Finals Medical Revision Podcast
T-Cell Disorders (2nd edition)

The Zero to Finals Medical Revision Podcast

Play Episode Listen Later May 4, 2026 7:03


This episode covers T-cell disorders.Notes: https://zerotofinals.com/paediatrics/immunology/tcelldisorders/Questions: https://members.zerotofinals.com/Books: https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

The Zero to Finals Medical Revision Podcast
Cow's Milk Protein Allergy (2nd edition)

The Zero to Finals Medical Revision Podcast

Play Episode Listen Later Apr 24, 2026 8:30


This episode covers cow's milk protein allergy.Notes: https://zerotofinals.com/paediatrics/immunology/cowsmilkallergy/Questions: https://members.zerotofinals.com/Books: https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

The Itch: Allergies, Asthma & Immunology
#154 - What Providers Need to Know About Uncontrolled Asthma

The Itch: Allergies, Asthma & Immunology

Play Episode Listen Later Apr 23, 2026 38:17


If you treat patients with asthma, this episode is for you. Not just allergists, but GPs, pediatricians, family medicine doctors, urgent care providers, and anyone who sees a patient with asthma in their practice. Dr. Cherie Zachary, current president of the American College of Allergy, Asthma and Immunology, joins Kortney and Dr. Payel Gupta to talk about why uncontrolled asthma remains a serious and largely preventable problem, and what providers can do differently starting with their next patient visit. What we cover in this episode about uncontrolled asthma The data behind the problem. ER visits, hospitalizations, and asthma deaths have not improved in years, and Dr. Zachary explains why that should concern every provider who treats asthma patients. An ER visit is a treatment failure. Dr. Zachary makes the case that any asthma patient who ends up in urgent care or the emergency room should trigger an immediate reassessment of their treatment plan, not just a course of steroids and a send-home. Five questions every provider should be asking. The episode walks through a standardized set of control questions designed to help providers catch uncontrolled asthma before it becomes a crisis, covering steroid use, ER visits, rescue inhaler use, nighttime waking, and daily activity limitations. Why patients normalize their symptoms. Providers hear what controlled asthma should actually look like, and why patients often don't volunteer the information needed to catch a problem. Who is most at risk. Dr. Zachary shares which patient populations are most likely to have uncontrolled asthma and least likely to be identified, and what providers can do to close that gap. More resources about uncontrolled asthma ControlYourAsthma.org  Free AAN Asthma Coach Program Find an allergist Understanding Oral Corticosteroid Overuse in Asthma Made in partnership with The Allergy & Asthma Network. Thanks to Sanofi-Regeneron for sponsoring today's episode.  This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

Dr. Brendan McCarthy
Ultra-Processed Foods & Autoimmunity

Dr. Brendan McCarthy

Play Episode Listen Later Apr 23, 2026 18:30


Today, we're diving into autoimmunity—what it actually is, why it happens, and how ultra-processed foods may be contributing to the problem. Autoimmune disease is often misunderstood. Some will tell you diet has nothing to do with it. Others claim diet is the cure. The truth is more nuanced—and that's exactly what we explore in this episode. You'll learn: What autoimmunity really is (and why it's a case of mistaken identity) How inflammation and the immune system interact The critical role of gut health and the microbiome How ultra-processed foods disrupt intestinal integrity and immune signaling Why stress and hyper-palatable foods create a harmful cycle A practical experiment you can try to see how diet impacts your own biomarkers This isn't about selling supplements or pushing extremes. It's about understanding the science so you can make informed decisions about your health. As always, this episode is backed by scientific literature. Full citations are included below, with abbreviated versions available on shorter clips. If you're dealing with autoimmune symptoms—or just want to better understand how food impacts your immune system—this episode is for you.   Full citation list: Hall KD, et al. “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake.” Cell Metabolism, 2019.     Supports the formulation argument: UPF intake increased spontaneous calorie intake and weight gain even with diets matched for presented calories, sugar, fiber, sodium, and macronutrients. This is your anchor for “hyper-palatability and formulation change physiology, not just psychology.”   Narula N, et al. “Association of Ultra-Processed Food Intake With Risk of Inflammatory Bowel Disease: Prospective Cohort Study.” BMJ, 2021.     Best human disease-level citation for the episode. Supports the claim that higher UPF intake is associated with greater IBD risk, making the gut-immune link clinically meaningful rather than purely theoretical.   Chassaing B, et al. “Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome.” Gastroenterology, 2022.     Best emulsifier paper for human translation. Supports the claim that CMC can perturb the microbiota and metabolome and may contribute to barrier-hostile gut ecology in susceptible individuals.   Daniel N, et al. “Human Intestinal Microbiome Determines Individualized Responses to Dietary Emulsifier Carboxymethylcellulose.” Cellular and Molecular Gastroenterology and Hepatology, 2024.     Useful nuance paper. Supports the point that emulsifier sensitivity is not identical across all people and that host-microbiome context matters.   Shil A, et al. “Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium Through Activation of the Sweet Taste Receptor T1R3.” Nutrients, 2020.     Best citation for the “sugar-free does not mean barrier-neutral” point. Supports direct epithelial barrier effects of common artificial sweeteners in experimental models.   Peng L, et al. “Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers.” Journal of Nutrition, 2009.     Classic mechanistic citation for butyrate. Supports the claim that loss of fermentable fiber and reduced butyrate production can weaken barrier function.   Kumar KP, et al. “The Interplay Between the Microbiota, Diet and T Regulatory Cells in Maintaining Intestinal Homeostasis.” Frontiers in Microbiology, 2023.     Useful for the tolerance language. Supports the argument that diet and microbial metabolites shape Treg biology and mucosal tolerance.   Haase S, et al. “Sodium Chloride Triggers Th17 Mediated Autoimmunity.” Frontiers in Immunology, 2019.     Key citation for high salt and autoimmune-prone immune skewing. Supports the claim that excess salt can promote pathogenic Th17 biology relevant to autoimmune disease.   Wilck N, et al. “Salt-Responsive Gut Commensal Modulates TH17 Axis and Disease.” Nature, 2017.     Strong bridge between salt, microbiome, and Th17 signaling. Supports the point that salt is not just a blood pressure story; it is also an immune-story.   Vitales-Noyola M, et al. “Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus.” Journal of Immunology Research, 2018.     Helpful human-facing citation for salt and immune skewing in autoimmune populations. Use cautiously, but it strengthens translation from theory to autoimmune terrain.   Phuong-Nguyen K, et al. “Advanced Glycation End-Products and Their Effects on Gut Health.” Nutrients, 2023.     Good review for the AGE section. Supports the argument that AGE-rich processed foods may worsen oxidative stress, microbiota balance, and barrier function.   Chen Y, et al. “Dietary Advanced Glycation End-Products Elicit Toxicological Effects by Disrupting Gut Microbiota and Increasing Colon Permeability in Rats.” Journal of Toxicology and Environmental Health, 2021.     Useful mechanistic support for the processing-chemistry section. Reinforces the claim that dietary AGEs can alter microbial ecology and increase permeability.   Monteiro CA, et al. “Ultra-Processed Foods: What They Are and How to Identify Them.” Public Health Nutrition, 2019.   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

The Zero to Finals Medical Revision Podcast
Allergic Rhinitis (2nd edition)

The Zero to Finals Medical Revision Podcast

Play Episode Listen Later Apr 22, 2026 7:27


This episode covers allergic rhinitis.Notes: https://zerotofinals.com/paediatrics/immunology/allergicrhinitis/Questions: https://members.zerotofinals.com/Books: https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

The Zero to Finals Medical Revision Podcast
Anaphylaxis (2nd edition)

The Zero to Finals Medical Revision Podcast

Play Episode Listen Later Apr 20, 2026 11:30


This episode covers anaphylaxis.Notes: https://zerotofinals.com/paediatrics/immunology/anaphylaxis/Questions: https://members.zerotofinals.com/Books: https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

The Zero to Finals Medical Revision Podcast

This episode covers allergy.Notes: https://zerotofinals.com/paediatrics/immunology/allergy/Questions: https://members.zerotofinals.com/Books: https://zerotofinals.com/books/The audio in the episode was expertly edited by Harry Watchman.

The Ripple Effect Podcast
Episode 579: The Ripple Effect Podcast (Dr. Alexander & Dr. Rose | WE ARE NOT MACHINES: Beyond Darwin & Algorithms)

The Ripple Effect Podcast

Play Episode Listen Later Apr 14, 2026 93:27


Dr. Jessica Rose & Dr. VN Alexander join The Ripple Effect Podcast for a deep, thought-provoking conversation that challenges mainstream assumptions about science, intelligence & reality itself. With backgrounds spanning computational biology, immunology, evolutionary theory & philosophy, they explore the limits of artificial intelligence, the complexities of living systems & why human consciousness cannot be reduced to algorithms. From questioning Darwinian orthodoxy to exposing the dangers of centralized technological power, this episode pushes beyond conventional thinking & invites listeners to reconsider what it truly means to be human in an increasingly artificial world.VN ALEXANDER, PhD (aka Tori):Website: https://vnalexander.com/IG: https://www.instagram.com/rednaxelairot/X: https://x.com/torialexander72Substack: posthumousstyle.substack.comThe Girlie Playhouse (Book): https://heresy-press.com/product/the-girlie-playhouse-by-v-n-alexander/DR. JESSICA ROSE:X: https://x.com/JesslovesMJKSubStack: https://jessicar.substack.com/YouTube: https://www.youtube.com/channel/UC0EhWf2Vswdg7DwKKKZ34ngDOAC AI Episode: https://www.youtube.com/watch?v=Cn8HBj8QAbkDOAC AI Debate: https://www.youtube.com/watch?v=JMYQmGfTltYTHE RIPPLE EFFECT PODCAST:WEBSITE: http://TheRippleEffectPodcast.comSUPPORT:PATREON: https://www.patreon.com/TheRippleEffectPodcastPayPal: https://www.PayPal.com/paypalme/RvTheory6VENMO: https://venmo.com/code?user_id=3625073915201071418&created=1663262894MERCH: Store: http://www.TheRippleEffectPodcastMerch.comTHEORY 6 MUSIC: https://open.spotify.com/artist/1w91xRlB4b2MJYyXXhJcyFSPONSORS:Descript – AI Video & Podcast Editor: https://descript.cello.so/l3sNyHZznJcOPUS A.I. Clip Creator: https://www.opus.pro/?via=RickyVarandasScott Horton Academy: https://scotthortonacademy.com/rippleeffectUniversity of Reason-Autonomy: https://www.universityofreason.com/a/2147825829/ouiRXFoLOFFICIAL YOUTUBE: https://www.youtube.com/@TheRippleEffectPodcastOFFICIALTHE UNION OF THE UNWANTED: https://linktr.ee/TheUnionOfTheUnwanted

music phd paypal algorithms machines immunology darwinian podcast dr podcast editor jessica rose ripple effect podcast therippleeffectpodcast theunionoftheunwanted
Dr. Chapa’s Clinical Pearls.
Livi Post-Sex Vaginal Device: Hmmmm

Dr. Chapa’s Clinical Pearls.

Play Episode Listen Later Apr 9, 2026 11:38


Livi by LiviWell is an FDA-cleared, single-use, soft polyurethane foam device designed to immediately absorb post-intercourse fluids (semen) to support vaginal health. Inserted like a tampon within 15 minutes post-coitus, it works in roughly 60 seconds to restore natural pH, helping to manage odor, dripping, and discomfort. Is this evidence-based? Listen in for details.1. https://www.biospace.com/press-releases/liviwell-secures-fda-clearance-for-livi-introducing-a-new-category-in-post-intercourse-vaginal-care#:~:text=Advertise-,LiviWell%20Secures%20FDA%20Clearance%20for%20Livi%2C%20Introducing%20a%20New%20Category,and%20other%20post%2Dintercourse%20fluids.2. Mngomezulu K, Mzobe GF, Mtshali A, et al. Recent Semen Exposure Impacts the Cytokine Response and Bacterial Vaginosis in Women. Frontiers in Immunology. 2021. 3. Abstract: ISSWSH/ISSM Joint Meeting 2025. Abstract citation ID: qdaf068.138 (155) SEMEN IS NOTTHEVAGINA'SFRIEND:ANOVEL POST-SEX TAMPON IMPROVES VAGINAL HEALTH PARAMETERS

Ask Dr. Drew
Meningitis Outbreak: Dr. Jessica Rose Exposes “Plandemic 2.0” Fear Campaign & MenB Vax w/ Dr. Izabella Wentz and Ken McCarthy – Ask Dr. Drew – Ep 603

Ask Dr. Drew

Play Episode Listen Later Mar 29, 2026 72:22


A meningitis outbreak is sparking a massive media fear campaign reminiscent of the early days of the COVID-19 pandemic – but Dr. Jessica Rose warns “don't just get in line like you did last time, please.” The computational biologist and immunologist warns that the public is being driven toward MenB vaccines that carry significant, underreported risks. By analyzing VAERS data and the recombinant technology inside these injections, Dr. Rose exposes the dangers of “molecular mimicry” and explains why injecting synthetic lipoproteins could trigger severe autoimmune responses. Internet pioneer and investigative author Ken McCarthy breaks down the historical and ongoing corruption of the medical industry. Dr. Izabella Wentz, acclaimed author of Hashimoto's Thyroiditis, shares her expertise on combating the rise of medically-induced and environmentally-triggered autoimmune conditions, offering root-cause solutions for mystery illnesses. Dr. Jessica Rose is a Canadian researcher with a Bachelor's in Applied Mathematics and a Master's in Immunology from Memorial University of Newfoundland. She holds a PhD in Computational Biology from Bar Ilan University and completed postdoctoral research in Molecular Biology and Biochemistry. Find her at https://jessicasuniverse.com and follow at https://x.com/JesslovesMJK Ken McCarthy was one of the early pioneers of the movement to commercialize the Internet. Time Magazine credits him with being the first person to articulate the importance of “click-through rate” as a key metric. He's the author of over 10 books, including the bestselling What the Nurses Saw. Learn more at https://BrasscheckBooks.com and https://kenmccarthy.com Dr. Izabella Wentz, PharmD, FASCP is an internationally acclaimed thyroid specialist and licensed pharmacist who has dedicated her career to addressing the root causes of autoimmune thyroid disease, fatigue and mystery illnesses after being diagnosed with Hashimoto's thyroiditis in 2009. She received the PharmD. Degree (Doctor of Pharmacy) from the Midwestern University Chicago College of Pharmacy at the age of 23. Dr. Wentz is the author of the #1 NYT bestseller “Hashimoto's Protocol” and multiple others. Learn more at https://thyroidpharmacist.com 「 SUPPORT OUR SPONSORS 」 • STRONG CELL – If you want to feel more like your younger self, go to https://strongcell.com/ and use code DREW for 20% off. • AUGUSTA PRECIOUS METALS – Thousands of Americans are moving portions of their retirement into physical gold & silver. Learn more in this 3-minute report from our friends at Augusta Precious Metals: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drdrew.com/gold⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or text DREW to 35052 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠• FATTY15 – The future of essential fatty acids is here! Strengthen your cells against age-related breakdown with Fatty15. Get 15% off a 90-day Starter Kit Subscription at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drdrew.com/fatty15⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • PALEOVALLEY - "Paleovalley has a wide variety of extraordinary products that are both healthful and delicious,” says Dr. Drew. "I am a huge fan of this brand and know you'll love it too!” Get 15% off your first order at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drdrew.com/paleovalley⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • THE WELLNESS COMPANY - Counteract harmful spike proteins with TWC's Signature Series Spike Support Formula containing nattokinase and selenium. Learn more about TWC's supplements at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twc.health/drew⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 「 ABOUT THE SHOW 」 This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. Executive Producers • Kaleb Nation - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://kalebnation.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • Susan Pinsky - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/firstladyoflove⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Content Producer • Emily Barsh - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/emilytvproducer⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Hosted By • Dr. Drew Pinsky - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/drdrew⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices