Podcasts about Immunology

With no FDA-approved therapies for Sjögren's disease, how can ENTs and allergists provide effective care and keep up with emerging treatments? On this episode of BackTable ENT & Allergy, Dr. Basil Kahwash interviews Dr. Kara Wada, a Columbus-based allergist, immunologist, and lifestyle medicine physician, about her personal and clinical experience with Sjögren's disease. They discuss the major gaps in current treatment, the evolving role of otolaryngologists and allergists in multidisciplinary care, and the new therapies on the horizon. --- Get the BackTable apphttps://www.backtable.com/app --- Timestamps 00:00 - Introduction02:21 - Building A Direct Practice04:24 - Personal Sjogren's Diagnosis08:33 - ENT Presentations11:28 - Biopsy Challenges and Seronegative Disease15:48 - Pulmonary Complications17:55 - Clinical Trial Treatment19:47 - Immunology and Disease Mechanisms25:35 - Lab Workup and Risk Assessment29:32 - Overlooked Symptoms and Nutritional Considerations31:51 - Saliva Stimulants Tradeoffs34:42 - Deciding When to Escalate Systemic Therapy35:51 - Hydroxychloroquine Basics38:26 - Multidisciplinary Dream Team41:45 - Rituximab and IVIG44:35 - Investigating Phase Three Therapies47:23 - Path to Becoming a Sjogrens Expert53:33 - Key Takeaways And Resources --- More about this episode Dr. Wada details her own diagnosis and the complex presentations of Sjögren's across ENT subspecialties, including dry eyes, nasal and throat tissues, chronic sinus issues, laryngitis, reflux, salivary gland swelling, neuropathy, and dizziness. The conversation covers diagnostic workup, the importance of lip biopsy and expert pathology, the challenges of seronegative and pulmonary cases, and the limitations of current medications like hydroxychloroquine and rituximab. They also discuss ongoing clinical trials, dryness management, overlooked symptoms, and the emerging role of agents such as inalumab and dazedalimab in late-phase studies. --- Resources Virtual Sjögren's Summithttps://www.sjogrenssummit.com/ --- BackTable ENT & Allergy is the go-to podcast for otolaryngologists, allergists, and head and neck surgeons. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

Today, on the Egg Whisperer Show podcast, I'm excited to be joined by Dr. Andrea Vidali. He is a world renowned endometriosis specialist, surgeon, miscarriage specialist and reproductive immunologist. Dr. Vidali is the founder and CEO of Pregmune, a healthcare information company that leverages his research in the fields of IVF and its relation to miscarriage and Immunology. I'm delighted to have him join us to talk about Pregmune and the role immunological factors play in fertility. In today's interview, we are going to be talking about what fertility patients need to know about immunological factors, how immunological factors may present themselves when diagnosed with "unexplained infertility," 6 important factors that may impact your ability to conceive, and how to get tested in order to see if any immunological factors may be involved when having difficulty conceiving.   Read the full show notes on Dr, Aimee's website. Tune in to the Egg Whisperer Show here. You can find Dr. Vidali at his website, here. Do you have questions about IVF, and what to expect? Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, September 14 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org  where you can schedule a consultation. Other places to find The Egg Whisperer: Click to find The Egg Whisperer Show podcast on your favorite podcasting app. Watch videos of Dr. Aimee answer Ask the Egg Whisperer Questions on YouTube.Sign up for The Egg Whisperer newsletter to get updates

The FDA has approved the first mRNA flu shot: Moderna's mFlusiva – but immunologist Dr. Jessica Rose says it safety tests are flawed. “… You will find the safety data that definitively shows that more people died in the context of the mRNA-1010 injectable product than in the comparator group,” writes Dr. Rose. “You should know that the comparator group ALSO were given a flu vaccine – NOT A SALINE PLACEBO.” Reuters reports the approval covers adults 50 and older, based on a late-stage trial of more than 40,000 people that showed the shot was 26.6% more effective than a licensed standard-dose flu vaccine. But Dr. Rose says that no saline placebo was used, and the comparator group also received a flu vaccine – and that the data she's seen indicates high adverse reactions to the new shots. Dr. Kelly Victory, Chief of Emergency & Disaster Medicine at The Wellness Company, joins Wellness Company CEO Peter Gillooly to discuss RFK's push to split the childhood MMR vaccine into separate shots, new releases from Dr. Fauci's pandemic text messages, and TWC's research on Alpha-Gal. Dr. Jessica Rose is a Canadian researcher with a Bachelor's in Applied Mathematics and a Master's in Immunology from Memorial University of Newfoundland. She holds a PhD in Computational Biology from Bar Ilan University and completed postdoctoral research in Molecular Biology and Biochemistry. Follow at https://jessicasuniverse.com Dr. Kelly Victory is Chief of Emergency & Disaster Medicine at The Wellness Company and a trauma and emergency specialist with over 30 years of experience. Follow at https://x.com/DrKellyVictory Peter Gillooly is CEO of The Wellness Company. Through the organization's initiatives and products, he promotes patient-first care and individual control over health decisions. 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Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. 「 ABOUT THE SHOW 」 This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. 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Time for Pat's weekly chat with Professor Luke O'Neill, professor of biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin and this week Pat and Professor O'Neil are looking at the persecution of Dr Anthony Fauci by the Trump administration.

Dr. Donard Dwyer is a Professor of Psychiatry and Behavioral Medicine and Vice Chair for Research at LSU Health Shreveport. With more than 30 years of academic research experience, his work has focused on neuroscience, genetics, motivation, schizophrenia, and the biological mechanisms underlying neuropsychiatric disorders. Before joining LSU Health Shreveport, Dr. Dwyer served as a Research Scientist at the Max Planck Institute in Würzburg, Germany, and as Director of Immunology for a Cambridge biotechnology company. His current research explores the genetic and molecular pathways involved in brain function, motivation, and potential new treatments for neuropsychiatric conditions. In this episode of Asking Why, Dr. Dwyer returns to discuss his latest research after his manuscript, “Suicide Risk Genes,” was accepted for publication in a prestigious medical journal. He shares the inspiration behind the research, the significance of the findings, and what they could mean for the future of neuroscience, suicide prevention, and mental health. Links Research Page (please link in the show notes): http://www.lsuhs.edu/psych-research Instagram: @lsuhs_psychiatry Facebook: LSUHS Psychiatry and Behavioral Medicine   Asking Why with Clint Davis Sponsors: A special thank you to the incredible sponsors of Asking Why with Clint Davis for investing in meaningful conversations that bring hope, healing, and growth to our community.   Wellness by Dr. Natalia — a physician-led integrative and concierge medical practice in Shreveport focused on longevity, regenerative medicine, aesthetics, and whole-person wellness. Learn more at www.LuraguizMD.com   Uprising Addiction Center — helping individuals and families find lasting recovery through compassionate, evidence-based addiction treatment focused on healing the whole person. Learn more at www.UprisingCenter.com   LearningRx Shreveport — empowering children and adults by strengthening cognitive skills needed to learn, focus, read, and succeed with confidence. Learn more at www.LearningRx.com/Shreveport   We're grateful for businesses and organizations that believe in strengthening people, families, and our community.      

President Trump has signed an executive order calling for a change to the childhood vaccination schedule. Specifically, he wants to separate the MMR vaccine, which protects against measles, mumps, and rubella, into three separate shots. There's no scientific research to indicate that these changes would be beneficial, and the order has sparked backlash from medical associations and drug manufacturers.  Meanwhile, over 2,400 people have contracted measles in the United States so far this year, topping the total number of cases for 2025 in just seven months. And with vaccination rates declining, there's a lot of conversation about what's driving vaccine hesitancy and how to combat misinformation.   Elisabeth Marnik has lived in both worlds: She wasn't vaccinated as a kid because her parents were concerned that vaccines could do harm. In high school, she fell in love with science. She went to college, got vaccinated, and then earned a PhD in immunology. She joins Flora to talk about what people misunderstand vaccine hesitancy, and how she approaches science communication in today's messy information ecosystem. Guest: Dr. Elisabeth Marnik is an immunologist and the executive director of The Evidence Collective. Transcripts for each segment will be available the week after the show airs on sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Asthma is often treated like a lung problem. The tighter the chest, the more inflamed the airway, the worse the flare-up, the answer has usually been to reach for medications designed to calm the lungs directly.But what if, for some patients, the real driver is not only in the lungs at all?For years, clinicians have recognized that patients with both obesity and asthma often experience a more difficult form of the disease. Their symptoms are more severe. Their flare-ups are more frequent. Their quality of life is lower. And frustratingly, many do not respond as well to the standard asthma therapies we rely on, including inhaled steroids.That is because obesity-related asthma is not simply “asthma plus extra weight.” It appears to be a distinct phenotype shaped by metabolic dysfunction, systemic inflammation, insulin resistance, immune reprogramming, and the mechanical effects of excess weight on lung function. In other words, for many patients, asthma may not be just a disease of the airways. It may be a whole-body inflammatory condition showing up in the lungs.That shift in thinking is why the growing research around GLP-1 receptor agonists is so compelling. These medications, originally developed for type 2 diabetes and now widely known for their role in weight management, may be doing far more than changing blood sugar or body weight. Emerging research suggests they may influence airway inflammation, immune signaling, airway smooth muscle function, and asthma exacerbation risk, sometimes even before major weight loss occurs.To explore what this could mean for the future of asthma care, Dr. Atoosa Kourosh, a board-certified allergist, immunologist, and pediatrician with more than two decades of clinical experience, returns to the show.She is the founder of Holistic Allergy and Immunology and chair of the Integrative Medicine Committee at the American College of Allergy, Asthma, and Immunology, where she brings together conventional medicine, lifestyle medicine, metabolic health, and integrative care.Together, we explore:Why obesity-related asthma is not just “regular asthma in a heavier body,” but a distinct phenotype with different biology, different inflammation, and often a different response to treatmentHow metabolic dysfunction, insulin resistance, adipokines, immune reprogramming, and systemic inflammation can all shape what happens in the lungsWhy standard asthma therapies may miss the mark for patients whose disease is driven less by classic allergic inflammation and more by metabolic inflammationWhat emerging research suggests about GLP-1 receptor agonists and their potential effects on airway inflammation, airway smooth muscle, bronchodilation, and asthma exacerbationsWhy some patients may see asthma improvement before significant weight loss, suggesting these medications may be acting on more than the scaleWhat real-world data can and cannot tell us about GLP-1 medications, asthma attacks, and patients with both asthma and type 2 diabetesWhy randomized controlled trials are still needed before GLP-1s can be considered a definitive asthma treatmentWhat clinicians and families should consider before using GLP-1 medications in adolescents, including growth, muscle loss, bone health, mental health, activity levels, and the need for careful testing and monitoringWhy these medications should be viewed as one tool in a broader lifestyle and integrative medicine toolkit, not a quick fix or a substitute for nutrition, movement, sleep, stress regulation, and anti-inflammatory livingHow this research could change the way we classify asthma in the future, moving from a lung-only model to a more metabolic, systems-based model of chronic inflammatory diseaseIf you are a clinician treating difficult-to-control asthma, a patient living with asthma and metabolic dysfunction, or someone trying to understand why chronic disease rarely fits into one neat category, this conversation will challenge you to look beyond the lungs and consider the whole body story.About the GuestDr. Atoosa Kourosh, MD, MPH, RYT, is a physician, board-certified in pediatrics, Allergy & immunology, and public health. She's also a patient health advocate, a Clinical Hypnotherapy practitioner, and a registered yoga teacher. Dr. Kourosh combines treatment modalities from cutting-edge and mainstream medicine with the best of functional and integrative medicine therapies and traditional philosophies to treat the whole person in their environment. She is the chair of the American College of Allergy, Asthma, and Immunology Integrative Medicine Committee and an internationally renowned expert in holistic and integrative health. Visit https://www.doctoratoosa.com/ to learn more.About Your HostHosted by Dr. Deepa Grandon, MD, MBA, a triple board-certified physician with over 23 years of experience working as a Physician Consultant for influential organizations worldwide. Dr. Grandon is the founder of Transformational Life Consulting (TLC) and an outspoken faith-based leader in evidence-based lifestyle medicine.ResourcesWork with Me - Learn More About My Soon-to-Launch Telemedicine PlatformExciting news—my virtual medical platform is launching soon! If you're looking for personalized, evidence-based care in allergy, immunology, and lifestyle medicine, stay tuned. Click here to join the wait-list and be the first to receive updates about services, membership options, and launch details.Precision care. Personalized guidance. Wherever you are.Feeling stuck and want guidance on how to transform your spiritual, mental and physical well being? Get access to Dr Deepa's 6 Pillars of Health video! Subscribe and watch the video for free here.Want to receive a devotional every week From Dr. Deepa? Devotionals are dedicated to providing you with a moment of reflection, inspiration, and spiritual growth each week, delivered right to your inbox. Subscribe now.Ready to deepen your understanding of trauma and kick start your healing journey? Explore a range of online and onsite courses designed to equip you with practical and affordable tools. From counselors, ministry leaders, and educators to couples, parents and individuals seeking help for themselves, there's a powerful course for everyone. Browse all the courses now to start your journey.Disclaimer​​TLC is presenting this podcast as a form of information sharing only. It is not medical advice or intended to replace the judgment of a licensed physician. TLC is not responsible for any claims related to procedures, professionals, products, or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services, or methods that might be referenced.

BUFFALO, NY — August 12, 2026 — A new #research paper was #published in Volume 18 of Aging on July 27, 2026, titled “Transcriptomic aging clock analysis identifies key genes in opioid dependence.” The study was led by first author Hai Duc Nguyen from the Division of Microbiology, Tulane National Biomedical Research Center, Tulane University. The corresponding author is Woong-Ki Kim, who is affiliated with the Division of Microbiology, Tulane National Biomedical Research Center, Tulane University, and the Department of Microbiology and Immunology at Tulane University School of Medicine. Opioid dependence is a chronic and relapsing condition associated with substantial health and societal burdens. Chronic opioid exposure can affect neuronal signaling, immune function, metabolism, and other biological processes, yet the molecular mechanisms underlying dependence remain incompletely understood. Increasing evidence also suggests that substance use disorders may be associated with molecular changes related to aging, raising questions about how chronic opioid exposure interacts with age-dependent processes in the brain. To investigate these relationships, the researchers conducted an in silico study integrating three complementary approaches: RNA sequencing-based transcriptomic profiling, transcriptomic aging-clock modeling, and analysis of previously published genome-wide association studies (GWAS). The transcriptomic analysis used a publicly available brain RNA-seq dataset containing 42 samples—21 healthy controls and 21 individuals with opioid dependence—while the genetic analysis incorporated findings from six independent GWAS. Full press release - https://www.aging-us.com/news-room/transcriptomic-aging-clock-reveals-age-related-molecular-patterns-in-opioid-dependence DOI - https://doi.org/10.18632/aging.206405 Corresponding author - Woong-Ki Kim - wkim6@tulane.edu Abstract video - https://www.youtube.com/watch?v=7VwU0mFGkbg Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206405 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, opioids, GWAS, transcriptomic clock To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

About this episode:   New research has identified massive fungal blooms in North America in the Cretaceous period, suggesting significant ecological upheaval before and after the asteroid wiped out the dinosaurs. In this episode: Arturo Casadevall, senior author of the study, explains why these findings are so significant and his hypothesis that fungi gave mammals an evolutionary leg-up over reptiles. Guest:  Dr. Arturo Casadevall, PhD, MS, is chair of the department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health and a global expert in host defense mechanisms, fungi, and antibody-based therapies. He is also co-author of the book What If Fungi Win? with Stephanie Desmon. Host:  Stephanie Desmon, MA, is a former journalist, author, and the director of public relations and communications for the Johns Hopkins Center for Communication Programs. Show links and related content:  Fungal Surges Marked Cretaceous Mass Extinction that Ended Age of Dinosaurs—Johns Hopkins Bloomberg School of Public Health What zombie show 'The Last of Us' gets right about fungus in a warming world—Washington Post What If Fungi Win?—Johns Hopkins University Press The Discovery of a New Clade of Candida Auris—A "Critical Pathogen"—Public Health On Call (August 2024) Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌PublicHealthPod on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

Women who test positive for bacterial vaginosis (BV) were over three times more likely to also test positive for one or more non-viral sexually transmitted infections (STIs) than women who test negative for BV, according to a new Health Trends® study from Quest Diagnostics and Hologic, Inc., published in the journal Obstetrics and Gynecology Open. Joining me today to discuss the study and what healthcare providers should do based on this information is Beth Marlowe , PhD. Dr Marlowe is Executive Scientific Director and heads R&D for Quest Diagnostics Infectious Diseases and Immunology and co author of the study.   Vaginitis and Sexually Transmitted Infections Coinfections

As part of our Autoimmunity x Immunotherapy series we explore the autoimmune disease known as systemic lupus erythematosus (SLE) or more simply, lupus with Dr. Maria Tokuyama. Dr. Tokuyama is an assistant professor in Microbiology and Immunology at the University of British Columbia, where she also runs a lab exploring the relationship between viruses and autoimmunity. With her we explore what lupus is, current treatments, and how immunotherapy is being used to treat it!--Interested in learning more about immunotherapy? Check out our other episodes and give us a follow on instagram @wthisimmunotherapy and twitter @WTHisImmunoT! And check out our website ⁠wthisimmunotherapy.com⁠. Or feel free to reach out to us at ⁠wthisimmunotherapy@gmail.com⁠ if you have any questions or any ideas for episodes!--Creators & Producers: Gillian Savage, Grace Bernard, and Dr. Pauline Loos Podcast Logo is designed by Mia Portelance Music is by Lara Antebi (⁠https://laraantebi.bandcamp.com/⁠)

VAERS stands for the 'Vaccine Adverse Effects Reporting System.' $ BTC 63,961 Block Height 961,091 Today's guest is Dr. Jessica Rose, PhD, MSc, BSc. Jessica is a Senior Fellow specializing in Computational Biology from Canada. She holds a Bachelor's Degree in applied mathematics and a master's degree in Immunology from Memorial University of Newfoundland, and a PhD in Computational Biology from Bar Ilan University. Dr. Rose has completed two post-doctoral degrees in Molecular Biology from the Hebrew University of Jerusalem, and in Biochemistry from the Technion Institute of Technology. She is best known for her contributions to public health and safety related to the COVID-19 injectable products, and her analyses of pharmacovigilance databases like VAERS. She joined me to discuss her analysis of the VAERS database and her critiques of the COVID-19 vaccine rollout and broader public health narratives. Key Topics: Analysis of the Vaccine Adverse Effects Reporting System (VAERS) Criticisms of COVID-19 mRNA injection data and safety Mechanisms of autoimmunity and potential side effects Data censorship and manipulation in scientific literature Historical context of vaccine liability and regulatory failures Strategies for immune optimization and health freedom Follow Jessica below. X- @JesslovesMJK https://jessicar.substack.com https://orcid.org/0000-0002-9091-4425 A huge thank you to Jessica for coming on the show! Check out my book ‘Choose Life' - https://bit.ly/4gGYqRE Pleb Service Announcements: Join 20 thousand Bitcoiners on @cluborange https://signup.cluborange.org/co/princey CONFERENCES: BTC HEL - 25th - 26th September 2026. - Helsinki https://btchel.com/ Use code BITTEN for - 10% My First Bitcoin. https://myfirstbitcoin.org/ Shills and Mench's: BITBOX - SELF CUSTODY YOUR BITCOIN - www.bitbox.swiss/bitten Use Code BITTEN THE MEETUP BREAKDWON - BITCOIN EVENTS UK - https://www.themeetupbreakdown.com/ SWAN BITCOIN - www.swan.com/bitten HODL EYEWEAR - Avoid Blue light! https://hodleyewear.com/partner/3/ PLEBEIAN MARKET - BUY AND SELL STUFF FOR SATS; https://plebeian.market/ @PlebeianMarket SATSBACK - Shop online and earn back sats! https://satsback.com/register/5AxjyPRZV8PNJGlM ALL FURTHER LINKS HERE - FOR DISCOUNTS AND OFFERS - https://vida.page/princey - https://linktr.ee/princey21m

Send us Fan MailHow the nervous and immune systems communicate, using peptides and other signals, to regulate pain, itch, and inflammation.TOPICS DISCUSSED:Nociception & Pathogens: Sensory neurons detect bacterial toxins within seconds, enabling rapid host-defense coordination ahead of immune-cell recruitment.CGRP & neutrophils: Nociceptor-release the peptide CGRP, which blocks neutrophil (immune cell) recruitment; pathogens exploit this in necrotizing fasciitis and meningitis.Pain sensitization: Inflammation can lower neuronal thresholds for pain, which sometimes becomes a chronic problem.Gut barrier protection: CGRP from gut nociceptors drives goblet-cell mucus secretion, supporting the protective “weep and sweep” response.Skin-to-gut allergy priming: Early skin exposure to allergens plus scratching may promote food allergies.Vagus nerve circuits: Distinct vagal sensory neurons selectively suppress TNF or induce IL-10, allowing precise inflammatory control.Brain inflammatory memory: Insular neurons encode site-specific immune responses that can later be recalled by reactivating those circuits. The brain remembers past inflammatory events.ABOUT THE GUEST: Isaac Chiu, PhD is a professor in the Department of Immunology at Harvard Medical School. His lab studies nervous-immune system crosstalk in pain, itch, infection, and inflammatory disease.RELATED CONTENT:Article | Inflammation Regulation by Omega Fats: How High ω-6 Intake Impacts ω-3 LevelsSupport the showSupport my work:Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.For all the ways you can support my efforts.

Tonight on America At Night with McGraw Milhaven, it's another edition of MacFarlane Mondays as investigative journalist and MeidasTouch chief Washington correspondent Scott MacFarlane joins McGraw to break down the latest political developments from the nation's capital, offering insight into the biggest stories shaping Washington. Then, Dr. Cynthia Sears, Professor of Medicine, Oncology, and Molecular Microbiology and Immunology at Johns Hopkins University, discusses the growing Cyclospora outbreak, what Americans should know about the foodborne parasite, and the concerning social media trend known as "parasite maxxing," where some people intentionally expose themselves to parasites based on misleading health claims. Plus, author Joshua Kendall joins the program to discuss his latest book, Trudeau & Doonesbury, exploring the life and legacy of legendary cartoonist Garry Trudeau, the impact of Doonesbury on American politics and culture, and why the comic strip continues to resonate decades after its debut. Learn more about your ad choices. Visit podcastchoices.com/adchoices

About this episode:   West Nile virus is the most common mosquito-borne illness in the U.S., and while most people who contract it won't even know they're infected, it can be debilitating for older adults and the immunocompromised. In this episode: an expert in insect-borne diseases gives listeners the essential information on West Nile, offers a forecast on this year's disease season, and answers the most important question: can we just get rid of mosquitoes? Guest:  Douglas Norris, PhD, is a professor of Molecular Microbiology and Immunology who studies vector-borne diseases. Host:  Lindsay Smith Rogers, MA, is the producer of the Public Health On Call podcast, an editor for Expert Insights, and the director of content strategy for the Johns Hopkins Bloomberg School of Public Health.  Show links and related content:  CDC Encourages Americans to Stay Mosquito Bite-Free during America's 250th Independence Day holiday weekend—CDC Early, intense West Nile season may signal a severe year for the mosquito-borne illness, CDC says—CNN How to Prevent Dengue or "Break-Bone Fever"—Public Health On Call (May 2024) Why Are Some Humans' Scents More Preferable to Mosquitoes?—Public Health On Call (June 2023) Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌PublicHealthPod on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

Luke O'Neill, School of Biochemistry and Immunology at TCD

Dr. Mariana Byndloss is Assistant Professor of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center. Research in Mariana's lab investigates how the bacteria that live inside our gut can affect our health. She is interested in how things like diet, antibiotics, or infection may change how our body behaves. This, in turn, can change how the bacteria in our gut behave and lead to disease. Outside of science, Mariana loves animals, and she spends a lot of her free time with her dog and new puppy. They are both German Shorthair Pointers, and she trains them to hunt and to participate in American Kennel Club competitions. Mariana also enjoys quality time with her husband and son, listening to live music, and exploring all the great restaurants in Nashville. Mariana earned her DVM, MSc in veterinary pathology, and PhD in veterinary pathology from the Universidade Federal de Minas Gerais (UFMG) in Brazil. She was awarded the Brazilian National Prize for best PhD thesis in Veterinary Medicine. Afterwards, Mariana conducted postdoctoral research at the University of California, Davis before joining the faculty at Vanderbilt University Medical Center. In our interview, Mariana will tell us more about her life and science.

Ep 292 Peacewarts Resonant Charms 101 - Rumor Immunology (Class 9) In class 9, we explore Rumor Immunology and the lumos charm. Using the 2017 Mosque Fire and the 2014 Ebola response as case studies, we discuss how to separate image heat from factual context. We cover the dangers of accidental amplification and provide tactical tools like the One-Step Rule, reverse image searching, and identifying language tripwires. Homework: Look up the 2017 Mosque Fire case or Finland's Media Literacy curriculum and find one "social speed bump" they suggest. Write down one question about any of this episode's topics. If you don't have a question, write 'no question.' Optional: Journal about the difference between private verification and public debunking. Books: If you'd like to read more on this subject, some book suggestions are Made to Stick: Why Some Ideas Survive and Others Die by Chip Heath and Dan Heath, which explores the exact anatomy of urban legends and rumors while providing the sticky psychology needed to build cultural immunity against misinformation, and The Constitution of Knowledge: A Defense of Truth by Jonathan Rauch, an academic powerhouse on how modern societies build robust, shared informational networks to verify facts and defend our collective understanding against panic. Learning Topics: Rumor Immunology; The Lumos Charm; The 2017 Mosque Fire Precedent; Verification vs. Amplification; The One-Step Rule; Reverse Image Searching; Language Tripwires. Join the Community / Get the Books:AvisKalfsbeek.com Podcast Music: Javier Peke Rodriguez “I am late, madame Curie”https://javierpekerodriguez.bandcamp.com/

It's time to build your family's future on a foundation of true health and freedom. Join us at Future Foundations—because your future generations deserve the best start to the mission that will outlive us… Check it out here. Use code FREEDOM25 for 25% off!    Whether you're looking for tinctures, topicals or teas or a deeper connection to your INNATE healing capacity, Noble Task Homestead is here to serve you. Join the movement. Visit NobleTaskHomestead.com/noblestan today and enjoy a 10% discount on your order.   San Diego area residents, take advantage of our special New Patient offer exclusively for podcast listeners here. We can't wait to experience miracles with you!   Welcome to another episode of the Future Generations Podcast. Today Dr. Stanton Hom sits down with nanoscientist and clinical lab expert Maria Crisler to expose what she's actually seeing under the microscope in both injected and uninjected populations. They unpack the transhuman agenda, smart dust, hydrogels, synthetic fascia, and why classic detox and "healthy lifestyle only" are no longer enough, then lay out the core principles of Maria's remediation program to protect our kids and future generations.   Highlights: "The blood doesn't lie, and biology is not the invader here."   "There is no such thing as safe blood anymore."   "If you own a cell phone, game over. These smart particles are activated by your environment."   "If you do nothing, it doesn't matter if you're injected or not, you're part of the problem."   Timestamps: 00:02 – Introduce 00:00 – Health Freedom as a Family Legacy 04:18 – Meet Maria: Lab Scientist Turned Nanoscience Whistleblower 08:48 – What Maria Sees in "Uninjected" Kids' Blood 11:58 – Stanton on Unvaccinated Injury, Shedding, and Smart Infrastructure 16:52 – "There Is No Safe Blood": Contamination of the Uninjected 24:23 – Is Our Environment Now More Synthetic Than Biological? 32:22 – Endocannabinoid System Under Attack & Why It Matters for Kids 42:08 – Human Data Centers, AI, and the Bio-Internet of Bodies 47:18 – Why Zeolite, Silica & Common Detoxes May Be Backfiring 59:03 – The Organism Detox Program: Synthetic, Hybrid, and Organic Cleanup   Resources:   Remember to Rate, Review, and Subscribe on iTunes and Follow us on Spotify!   Learn more about Dr. Stanton Hom on:   Instagram: https://www.instagram.com/drstantonhom    Website: https://futuregenerationssd.com/  Podcast Website: https://thefuturegen.com  Twitter: https://twitter.com/drstantonhom   LinkedIn: https://www.linkedin.com/in/stanhomdc   Stay Connected with the Future Generations Podcast:   Instagram:  https://www.instagram.com/futuregenpodcast   Facebook: https://www.facebook.com/futuregenpodcast/     About Maria Crisler: Maria Crisler: Founder and CEO of Abeytu Naturals    A.S., B.S., CLS (NCA), MBA/HCM   She is a successful medical business owner with extensive expertise in Clinical Microbiology and Immunology. In addition to executive leadership and management responsibilities, Maria is actively involved in clinical product design and development. She plays a key role in identifying consumer needs and facilitating effective applications for individuals with chronic conditions across the supplement, medical, and pharmaceutical industries. Social Links:   ~ Website: https://abeytunaturals.com/pages/about   ~ Facebook: https://www.facebook.com/share/1BE9RytauX/?mibextid=wwXIfr   ~ Facebook: https://www.instagram.com/abeytu_naturals?igsh=MXFpYjI2dWd0cmlnOA==  ~ Pin: https://pin.it/68YzrVWlu    The desire to go off grid and have the ability to grow your own food has never been stronger than before. No matter the size of your property, Food Forest Abundance can help you design a regenerative layout that utilizes your resources in the most synergistic and sustainable manner. If you are interested in breaking free from the system, please visit www.foodforestabundance.com and use code "thefuturegen" to receive a discount on their incredible services.   Show your eyes some love with a pair of daylight or sunset (or both!) blue-light blocking glasses from Ra Optics. They have graciously offered Future Generations podcast listeners 10% off any purchase. Use code FGPOD or click here to access this discount, and let us know how your glasses are treating you!   One of the single best companies whose clean products have supported the optimal wellness of our family is Earthley Wellness. Long before there was a 2020, Kate Tetje and her team have stood for TRUTH, HEALTH and FREEDOM in ways that paved the way for so many of us. In collaboration with this incredible team, we are proud to offer you 10% off of your first purchase by shopping here.   Are you concerned about food supply insecurity? Our family has rigorously sourced our foods for over a decade and one of our favorite sources is Farm Match and specifically for San Diego locals, "Real Food Club PMA". My kids are literally made from their maple breakfast sausage and the amazing carnitas we make from their pasture raised pork. We are thrilled to share 10% off your first order when you shop at this link.   Another important way to bolster food security is by supporting local ranchers. Our favorite local regenerative ranch is Perennial Pastures. They have the best nutrient-dense meats that are 100% grass-fed and pasture-raised. You can get $10 off of your first purchase when you use the code: "FUTUREGENERATIONS" at checkout. Start shopping here.

In this episode of The Better Life, Dr. Pinkston sits down with Harvard-trained physician, consultant, and author Dr. Michael Myers Jr. to tackle the complex and often controversial topic of vaccines through the lens of sound science and clear data. With deep expertise as a former chief of primary care and pediatrics, Dr. Myers previews his upcoming book, The Vaccine Bible, and unpacks how immunization works as a reliable tool for long-term health and disease prevention. Together, Dr. Pinkston and Dr. Myers address the most common concerns shared by patient communities today, including the safety of combination shots, the reality of preservatives, and the thoroughly debunked links between vaccines and autism. They look closely at the critical role vaccines play in modern longevity—highlighting massive clinical wins like the shingles vaccine’s link to reduced dementia risk, and cancer-preventing tools like the Gardasil and Hepatitis B vaccines. Dr. Myers also breaks down the rapid development and safety of mRNA technology used during the COVID-19 pandemic. Tune in for an honest, evidence-based conversation that bridges the gap between integrative health practices and conventional immunology, empowering you to perform your own objective risk assessment for you and your family. https://www.drmikemyers.com/ See omnystudio.com/listener for privacy information.

July 17, 2026 ~ Dr. Christian Nageotte, service chief of Allergy and Immunology at Henry Ford West Bloomfield Hospital discusses health effects of the wildfire smoke. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Guest: Dr. Andrew Hogan is a Professor and Principal Investigator of the Obesity Immunology Research Group at Maynooth University. He discusses how obesity drives chronic inflammation and immune dysfunction, increasing the risk of diseases such as diabetes and cancer, while highlighting the immune system’s role in disease progression. He also explains how GLP-1 therapies improve both metabolism and immune function, offering new insights into obesity treatment. Featured Products and Resources: Request your free EasySep sample and share your experience for a chance to win prizes worth up to $3,000! Win 350 US dollars or equivalent toward refreshments to fuel your journal club discussions. The Immunology Science Round Up Innate Immunity Predicts Symptoms – Stronger innate immune responses predisposed people to influenza symptoms while also promoting antiviral immune activation. Broad HIV Neutralization #1 – A novel HIV immunogen induced broadly neutralizing antibodies in macaques, providing a promising blueprint for HIV vaccine development. Broad HIV Neutralization #2 – A germline-targeting vaccine induced broadly neutralizing HIV antibodies in nonhuman primates. CAR-T Targets Glioblastoma – A dual-targeting CAR-T therapy achieved durable glioblastoma control in preclinical models. Image courtesy of Dr. Andrew Hogan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Professor Luke O'Neill, School of Biochemistry & Immunology at Trinity College Dublin

Sally Powell Price, PG.Dip., M.Sc. joined MilliporeSigma in 2020 as a Regulatory Subject Matter Expert for Public Health focusing on food safety, testing, and environmental monitoring in North America. Previously, she served as Food and Environmental Lab Supervisor at the New York City Department of Health Public Health Laboratory, and as Director of Lab Operations at a Boston-based startup. She holds a bachelor's degree in Biology from Hamilton College and an M.Sc. degree in Microbiology and Immunology from James Cook University (Australia), and completed her professional training at Harvard T.H. Chan School of Public Health. Sally currently co-chairs both the International Government Relations Committee and the Laboratory Science and Technology Committee for the Association of Food and Drug Officials (AFDO). She is a member of the World Health Organization (WHO) Food Safety Communities of Practice and has served as an Advisory Panel member for several AOAC International working groups.  Justyce Jedlicka, M.B.A. works in North America Commercial Applications for Food, Beverage, and Industrial Regulatory for MilliporeSigma, where she is responsible for engaging with influencers in the food and beverage industry to align initiatives with regulatory compliance and promote best practices for food safety and quality testing methods. Justyce has been serving the food and beverage industry since 2013, and received both a B.S. degree in Chemistry and an M.B.A. degree from the University of Missouri in St. Louis. She previously served as the Chair of the Food Sciences Section of the American Council of Independent Labs (ACIL) and currently serves on the Food Science Section Executive Committee at ACIL and the Board of Directors for the Independent Laboratory Institute. She is a member of IAFP, ISBT, SMA, and AOAC. In this episode of Food Safety Matters, we speak with Sally and Justyce [2:51] about: Emerging food risks in North America, and how the concept of a "food risk" has evolved over the past decade Differences and similarities in how regulators are handling novel versus established food risks What a rapid and agile response to a food risk might look like, whether such a response exists in North America, and whether existing regulatory frameworks can become more proactive than reactive Manufacturers' challenge of balancing speed-to-market with regulatory compliance in an evolving risk landscape The greatest tensions between food innovation and regulatory readiness in the North American market Whether contract laboratories and testing laboratories are equipped to keep pace with emerging food risks How companies can future-proof their testing and compliance strategies The role that scientific partners like MilliporeSigma play in helping regulators and manufacturers become more agile in an evolving food risk landscape. Resources MilliporeSigma for Food Safety Sponsored by: MilliporeSigma We Want to Hear from You! Please send us your questions and suggestions to podcast@food-safety.com

References Nat Struct Mol Biol . 2006 Dec;13(12):1097-101Open Biol. 2013 Oct;3(10):130144Arthritis Res Ther.2021; 23: 19.European Review for Medical and Pharmacological Sciences 2021; 25: 1425-1435Frontiers in Immunology 2024 09 January DOI 10.3389/fimmu.2023.132280Guerra, DJ. 2026.Unpublished Lectures.Teleman, G P 1716. Concerto in D. TWV51 https://music.youtube.com/watch?v=F5J80v3ACbo&si=oiJxKkpbnLhiZ833Hunter/Garcia.1973. Stella Blue. Grateful Dead.https://music.youtube.com/watch?v=VKsWDyvWaL4&si=Jul71w1djWl2WTIIp. 1716. D1 TWV51.

ReferencesFrontiers in Immunology 2014. November 21(578):1Clin Epigenetics. 2017; 9: 94. Cancer Cell International 2020. September 20(1):429Guerra, DJ.2026. Unpublished Lectures.Vinsom/Chapman/Burnett. 1930. Sitting On Top of the World Creamhttps://open.spotify.com/track/0aY5bJ4jRHiOd8eCMWmcy8?si=b3c7f2090c6e441cJagger/Richards.1965.Satisfaction Rolling Stoneshttps://open.spotify.com/track/2PzU4IB8Dr6mxV3lHuaG34?si=6b244c676bf1454eLennon/McCartney. 1968 Helter Skelterhttps://open.spotify.com/track/0Bs0hUYxz7REyIHH7tRhL2?si=f345fea1161a4f27Paige/ Plant 1971. Rock and Roll Led Zepplinhttps://open.spotify.com/track/4PRGxHpCpF2yoOHYKQIEwD?si=3203893185c24bee

The study from Trinity College in Dublin, Professor Cliona O'Farrelly, from Trinity's School of Biochemistry and Immunology who led the study spoke to Rachael.

Scientist and physician Michael Nehls explains how Alzheimer's can be reversed. Michael Nehls, MD, PhD, is a physician and molecular geneticist. As a basic researcher, he has deciphered the genetic causes of various hereditary diseases at German and international research institutions. He has published two of his discoveries in collaboration with several Nobel laureates. His discovery of a key gene in the development of immunity was honored as a "Pillar of Immunology" by the prestigious American Association of Immunology. A science writer with a talent for making complex issues accessible to a wide audience, he has written several best-selling books that have been translated into many languages. As a private lecturer, he is a popular speaker at conferences and universities. Find him here: Substack: michaelnehls.substack.com Web: https://michael-nehls.com X: @NehlsMD Paid partnerships with: Angel Studios: Become a Premium Angel Guild member today at http://angel.com/TuckerCharity Mobile: A pro-life company serving pro-life customers and supporting pro-life causes for 30 years. Use promo code TUCKER to get a free phone with free activation, free shipping, and a free gift with every new line of service at https://charitymobile.com/Tucker VanMan: Use code TUCKER for 15% off your first order at http://vanman.shop/tucker Learn more about your ad choices. Visit megaphone.fm/adchoices

ReferencesGut 2004;53:480–486. Immunol Rev 2014., 261: 62-83Nat Immunol. 2019 Aug 12;20(9):1174–1185.The Journal of Immunology, 2026.Volume 215, Issue 5, May vkag103Guerra, DJ. 2026. Unpublished LecturesMozart, WA. 1788. Divertimento String Trio in E Flat Major K.563https://music.youtube.com/watch?v=WNse4T666Ss&si=4cTDzDE4E-mX9NVz

Send us Fan MailMore than 200 million people around the world are infected with schistosomiasis, one of the neglected tropical diseases. It is caused by parasitic worms and prevalent in Africa, the Middle East, South America and Asia with close to 800 million people at risk for infection. If we in the U.S. are not in immediate threat of contracting the disease, why should we want to know more about it? To answer that and to explain more about the disease –– how people are infected, who is at risk, what the symptoms are and how it's currently treated –– is Afzal Siddiqui, Ph.D., a Grover E. Murray Distinguished Professor, director of the TTUHSC Center for Tropical Medicine and Infectious Diseases and chair of the Department of Immunology and Molecular Microbiology in TTUHSC's School of Medicine. Siddiqui also shares with us his decades-long work as part of a team developing a vaccine, updates us on the progress of the clinical trials and how work done on this vaccine could be useful to develop other vaccines as well. About SchistoShield®

How do you protect your time, stay current, and thrive after leaving academic medicine for private practice in a fast-evolving allergy and immunology specialty? In this episode of BackTable Industry, host Anish Parikh talks with Dr. Basil Kahwash, an allergist-immunologist, about his journey from internal medicine training through academic medicine at Vanderbilt and back to community practice in Columbus. They discuss the challenges of protecting time, adapting to higher patient volumes, and staying up to date as allergy and immunology rapidly evolve. --- Get the BackTable apphttps://www.backtable.com/app --- Timestamps 00:00 - Introduction02:57 - Academics vs. Private Practice08:30 - From Evidence to Practice10:53 - Staying Current Online13:23 - Group Chats and Timing16:40 - Posting and Info Quality25:05 - AI Decision Support27:00 - Patients Using ChatGPT and Closing Remarks --- More about this episode Dr. Kahwash contrasts academia's structured time for teaching and research with the demands of private practice, where non-clinical work requires deliberate effort. He highlights the field's recent shifts, including the rise of oral immunotherapy and biologics, and explains how he keeps pace with new developments through CME, journals, online platforms, and group chats. The conversation explores the pros and cons of information democratization, the impact of AI decision support, and the growing trend of patients arriving with ChatGPT-informed questions. Dr. Kahwash also discusses the integration of allergy and ENT practices and shares practical advice for clinicians navigating a fast-changing specialty. --- Backtable Industry is the go-to podcast for healthcare leaders, business-minded providers, and innovators that are shaping the future of healthcare. Download the free BackTable app to get early access to new episodes. ► https://www.backtable.com/app

Join the Wealthy Practitioner Tour with Dr. Stephanie Wigner this August! Visit the Wealthy Practitioner Tour to get your tickets today. It's time to build your family's future on a foundation of true health and freedom. Join us at Future Foundations—because your future generations deserve the best start to the mission that will outlive us… Check it out here. Use code FREEDOM25 for 25% off!    Whether you're looking for tinctures, topicals or teas or a deeper connection to your INNATE healing capacity, Noble Task Homestead is here to serve you. Join the movement. Visit NobleTaskHomestead.com/noblestan today and enjoy a 10% discount on your order.   San Diego area residents, take advantage of our special New Patient offer exclusively for podcast listeners here. We can't wait to experience miracles with you!   Welcome to a new episode of the Future Generations Podcast! Today, Dr. Stanton Hom sits down with Dr. Patrick Flynn, a chiropractor, immunology geek, and founder of a rapidly growing network of clinics known for life-changing clinical results. In this episode, they unpack the clash between the dominant medical "firefighter" model and a chiropractic "carpenter" paradigm that sees the body as intelligently adaptive, not broken. From trauma, toxins, and thoughts to auto-suggestion, vaccines, fertility, and the gut–brain–immune connection, Dr. Flynn lays out how chiropractic thinking reshapes labs, lifestyle, and long-term outcomes. You'll hear real clinical stories, hard questions about responsibility and prevention, and a powerful call for chiropractors and patients alike to reclaim a vitalistic, principle-driven approach to health and freedom.   Highlights: "You don't see the world the way it is, you see the world the way you are."    "True preventative health care is more of a chiropractic principle."    "A true scientist will always have a comma in his sentence, not a period."   "I'm a chiropractor. That just separates me from the thinking that dominates us today."    Timestamps: 00:00 - Introduction 01:39 – Medical vs. Chiropractic: Two Different Paradigms 03:31 – Innate Intelligence and the Adaptive Body 05:55 – Fever, Intelligence, and Misunderstood Symptoms 06:45 – Prenatal Case: Gestational Diabetes & Nervous System State 12:45 – Auto-Suggestion, Brainwashing, and Immune Collapse 18:24 – Firefighters vs. Carpenters: A New Healthcare Analogy 20:49 – What They Don't Tell You About Vaccines and Inflammation 36:29 – The Holistic Health Trap & Responsibility 42:17 – FBI at the Door & Standing on Principle Resources:   Remember to Rate, Review, and Subscribe on iTunes and Follow us on Spotify!   Learn more about Dr. Stanton Hom on:   Instagram: https://www.instagram.com/drstantonhom    Website: https://futuregenerationssd.com/  Podcast Website: https://thefuturegen.com  Twitter: https://twitter.com/drstantonhom   LinkedIn: https://www.linkedin.com/in/stanhomdc   Stay Connected with the Future Generations Podcast:   Instagram:  https://www.instagram.com/futuregenpodcast   Facebook: https://www.facebook.com/futuregenpodcast/     About Dr. Patrick Flynn: Dr. Patrick Flynn is a chiropractor and the founder of The Wellness Way. He is a highly sought-after speaker and best-selling author with educational training from numerous learning institutions including Palmer College of Chiropractic, The University of Wisconsin Green Bay, The University of Wisconsin Marinette, Scott College, Northwestern Health Sciences University, National University of Health Sciences, and courses at Harvard Medical School – HMX Fundamentals Online Certificate Program – in Immunology, Virology and Vaccines, and Health and Wellness: Designing a Sustainable Nutrition Plan. Pioneering a different approach to healthcare, he has trained Chiropractors, M.D.s, Nurse Practitioners, Nurses, Surgeons, Pharmacists, Health Restoration Coaches, and others. His network is now comprised of over 60 clinics seeing people from around the world. Find Him on Social Media Here: Instagram: https://www.instagram.com/drpatrickflynn/ YouTube: https://www.youtube.com/@DrPatrickFlynnDC TikTok: https://www.tiktok.com/@dr..patrick.flynndc Facebook: https://www.facebook.com/drpatrickflynn/ The desire to go off grid and have the ability to grow your own food has never been stronger than before. No matter the size of your property, Food Forest Abundance can help you design a regenerative layout that utilizes your resources in the most synergistic and sustainable manner. If you are interested in breaking free from the system, please visit www.foodforestabundance.com and use code "thefuturegen" to receive a discount on their incredible services.   Show your eyes some love with a pair of daylight or sunset (or both!) blue-light blocking glasses from Ra Optics. They have graciously offered Future Generations podcast listeners 10% off any purchase. Use code FGPOD or click here to access this discount, and let us know how your glasses are treating you!   One of the single best companies whose clean products have supported the optimal wellness of our family is Earthley Wellness. Long before there was a 2020, Kate Tetje and her team have stood for TRUTH, HEALTH and FREEDOM in ways that paved the way for so many of us. In collaboration with this incredible team, we are proud to offer you 10% off of your first purchase by shopping here.   Are you concerned about food supply insecurity? Our family has rigorously sourced our foods for over a decade and one of our favorite sources is Farm Match and specifically for San Diego locals, "Real Food Club PMA". My kids are literally made from their maple breakfast sausage and the amazing carnitas we make from their pasture raised pork. We are thrilled to share 10% off your first order when you shop at this link.   Another important way to bolster food security is by supporting local ranchers. Our favorite local regenerative ranch is Perennial Pastures. They have the best nutrient-dense meats that are 100% grass-fed and pasture-raised. You can get $10 off of your first purchase when you use the code: "FUTUREGENERATIONS" at checkout. Start shopping here.

Nurse Doza breaks down five signs your gut microbiome may be off — a history of antibiotics, brain fog, autoimmune issues, relentless sugar cravings, and not pooping every day. He explains how gut bacteria help shape neurotransmitters, blood sugar, and natural GLP-1, why so many issues trace back to the gut, and the simple steps — fasting, fermented foods, fish oil, and the Good Poops Protocol — that can help rebuild it from the inside out. FEATURED PARTNER — Good Poops Protocol (MSW Nutrition) This episode centers on rebuilding the gut microbiome, and the Good Poops Protocol is the bundle Nurse Doza built for exactly that — Gut, Liver Boost, and Berberine Plus working together over 60 days to support the intestinal lining, healthy bile flow, and blood-sugar metabolism. Berberine and L-glutamine are both studied for supporting the body's own GLP-1 production, making the protocol a practical starting point for the digestive issues discussed in this episode.

AABP Executive Director Dr. Fred Gingrich is joined by AABP Vice President and Preconference Seminar Coordinator Dr. Elizabeth Quesnell Kohtz. Preconference seminars are small group courses focusing on a specific topic offering high quality continuing education. Seminars are a great way to learn a new skill or advance skills to offer services to your beef and dairy clients.  Seminars are approved for eight hours per day of continuing education in jurisdictions that recognize RACE approval. These courses are an AABP member benefit and available to members who are veterinarians, veterinary technicians and students. There will be six seminars offered at the conference. There is also a student-only lameness seminar that will also be offered. Seminars available at the Minneapolis conference are below. Click on the name of the seminar to view a description and detailed agenda. Seminar 1 – Milk quality: Practical knowledge for boots on the ground veterinariansSeminar 2 – Bovine Dystocia and Fetotomy SeminarSeminar 3 – Transition cow health and managementSeminar 4 – From anecdote to evidence: conducting impactful field research in private practiceSeminar 5 – Immunology and vaccinology across beef and dairy production systemsSeminar 6 – Anesthesia, analgesia and sedation All conference information can be found under the Continuing Education menu of the AABP website. View session descriptions here. Register for the conference by going to this link. Early bird discounted registration ends July 16 so register before that date. Hotel information can be found on this page. Seminars with an inadequate number of registrations on July 16 are subject to cancellation with a full refund available if cancelled.  #AABP2026  

In advance of Ireland's upcoming European Presidency, Pat talks to Luke O'Neill, Professor of Biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin, about the European Research Council's recent meeting in Dublin, and how Europe compares with the rest of the world in science and technology.

How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life's experiences.In this episode, Dr Camidge sat down with Mary (Nora) L. Disis, MD, a professor in the Clinical Research Division at Fred Hutchinson Cancer Center; as well as a professor in the Division of Hematology and Oncology, an adjunct professor of pathology in obstetrics and gynecology, holder of the Helen B. Slonaker Endowed Professorship for Cancer Research, director of the Cancer Vaccine Institute, and associate dean for Translational Health Science at the School of Medicine at the University of Washington in Seattle.Drs Camidge and Disis discussed Dr Disis's evolution from a science-focused student to a global leader in cancer immunology. Raised in a family that prioritized education, Disis found her passion for chemistry as a young adult before pursuing an MD and a master's degree. Although deeply drawn to practicing medicine in rural communities, she ultimately chose to focus on the field of tumor immunology.In the discussion, Disis offered a candid look at the strategic discipline required to succeed as a clinician-scientist. She emphasized the importance of protecting research time and refusing to let clinical duties overshadow her lab work. Her pioneering research involved identifying HER2 as a tumor antigen and developing vaccines that demonstrated significant long-term survival through intermolecular epitope spreading.Beyond the lab, Disis highlighted how her editorial roles allow her to observe scientific trends and maintain a broad understanding of the clinical landscape. Ultimately, Disis emphasized that the path to cancer prevention and vaccine licensing requires finance, focus, fortitude, and fearlessness. Having witnessed immunotherapy become a standard of care, she remains dedicated to climbing the mountain of vaccine development. By sifting through scientific “buzz” and maintaining deep focus, Disis believes the next frontier of cancer research lies in immunizing individuals to prevent cancer from ever developing.

When should recurrent sinus infections trigger an allergy or immune workup? In this episode of the BackTable ENT and Allergy podcast, Dr. Karen Kaufman of Kaufman Allergy, Asthma, & Immunology in Vienna, Virginia, sits down with Dr. Ashley Agan to discuss chronic sinusitis evaluation, allergy testing, immunotherapy, immune deficiency screening, and building a private practice. --- Get the BackTable apphttps://www.backtable.com/app --- Timestamps 00:00 - Introduction02:53 - Chronic Sinusitis Basics06:44 - Sinusitis Types and Polyps10:18 - Testing and Treatment Plan18:40 - When to Suspect Immunodeficiency25:44 - Allergy Testing Methods38:39 - Why Go Solo43:10 - Practice Growth, Visibility, Team Building, and Systems51:55 - ENT and Allergy Collaboration55:50 - Closing Remarks --- More about this episode Dr. Kaufman explains how to distinguish chronic sinusitis from other causes of nasal and facial symptoms, when to evaluate for allergy and immune dysfunction, and how sinusitis phenotypes influence treatment decisions. She also shares her experience launching a private practice during the pandemic and discusses strategies for practice growth through community engagement, increased visibility, and social media. --- Resources Dr. Karen Kaufman - https://kaufmanallergy.com/ Jeffery Modell Foundation 10 Warning Signs of Primary Immunodeficiency - https://www.uhhospitals.org/-/media/files/rainbow/services/allergy-and-immunology/10warningsigns.pdf --- BackTable ENT & Allergy is the go-to podcast for otolaryngologists, allergists, and head and neck surgeons. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

About this episode:   A group of students from suburban Atlanta has developed a new method for detecting Lyme disease using the gene-editing tool CRISPR. In this episode: why there's such a desperate need for a new diagnostic, how the students' model works, and why it's so promising for the treatment of Lyme and other diseases.  Guest:  Nicole Baumgarth, PhD, DVM, is Bloomberg Distinguished Professor in Molecular Microbiology and Immunology and the director of the Lyme and Tickborne Disease Research and Education Institute at the Johns Hopkins Bloomberg School of Public Health.  Sankalp Yeleti is a recent graduate of Lambert High School and a rising freshman at New York University, where he plans to study biomolecular science.  Host:  Lindsay Smith Rogers, MA, is the producer of the Public Health On Call podcast, an editor for Expert Insights, and the director of content strategy for the Johns Hopkins Bloomberg School of Public Health.  Show links and related content:  Teens may have come up with a new way to detect, treat Lyme disease using CRISPR gene editing—CBS News  Lancet—Lambert iGEM 2025 Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌PublicHealthPod on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

Matters Microbial #132: What 83,000 Generations of Bacteria Reveal About Evolution June 17, 2026 Today Dr. Jeffrey Barrick, John A. Hannah Distinguished Professor of the Department of Microbiology, Genetics, & Immunology and the Department of Entomology at Michigan State University, joins the quality quorum today to discuss how microbes can be used to study evolution itself. He will also discuss the impressive and ongoing LTEE program, the experiments that originate from it, and what they tell us about evolution. Host: Mark O. Martin Guest: Jeffrey Barrick Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode Here is a link to an article about the late great Abigail Salyers. Here is what I wrote about Dr. Salyers. I learned so much from her.  An article about the contributions of Dr. Theodosius Dobzhansky to the study of evolution. The concept of contingency during evolution. An overview of microbial evolution. A link to "Microbes and Evolution," a book discussed during this podcast. A link to "A Primer for Experimental Evolution," a book discussed during this podcast. The concept of Growth Advantage in Stationary Phase (GASP). A video about the MEGA plate experiment by Dr. Michael Baym and colleagues. This is a "must watch." An video about Dr. Richard Lenski, originator of the LTEE. Dr. Lenski's website.  The LTEE (long term evolutionary experiment) website.  There is so much here to explore. An excellent introduction to the LTEE. An article about the amazing " climbing citrate mountain" innovation during LTEE described in the podcast. A video by Dr. Lenski about LTEE. A video by Dr. Barrick that is worth your time. Dr. Barrick's faculty website at Michigan State University. Dr. Barrick's research laboratory website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

This podcast has been funded by an educational grant from Viatris. Systemic lupus erythematosus (SLE) is a complex, heterogeneous disease shaped by dysregulated immune pathways, variable organ involvement, and substantial patient burden. In this educational podcast, Anca Askanase explores how a deeper understanding of SLE immunology can help rheumatologists contextualize disease activity, evolving research, and guideline-based care. Topics covered: Key immune pathways involved in SLE pathophysiology, including innate and adaptive immune dysregulation  How pathway biology may help explain clinical heterogeneity and differences in disease activity between patients  What rheumatologists should consider when interpreting emerging pathway-based research and cross-disease immunology concepts  How current guideline-based care frames treatment goals, patient burden, and the evolving focus on remission in SLE  Speakers Anca D. Askanase, Chair, Department of Medicine, and Chief, Division of Rheumatology, Hospital for Special Surgery, New York, USA

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBiblioBernardi, Luciano, Peter Sleight, Gabriele Bandinelli, Simone Cencetti, Luciano Fattorini, Johanna Wdowczyc-Szulc, and Alfonso Lagi. “Effect of Rosary Prayer and Yoga Mantras on Autonomic Cardiovascular Rhythms: Comparative Study.” BMJ 323, no. 7327 (2001): 1446–1449.Benson, Herbert, John W. Lehmann, Mark S. Malhotra, Ralph F. Goldman, Jeffrey Hopkins, and Mark D. Epstein. “Body Temperature Changes During the Practice of g Tum-mo Yoga.” Nature 295 (1982): 234–236.Benson, Herbert, Mark S. Malhotra, Ralph F. Goldman, Gregory D. Jacobs, and Jeffrey Hopkins. “Three Case Reports of the Metabolic and Electroencephalographic Changes During Advanced Buddhist Meditation Techniques.” Behavioral Medicine 16, no. 2 (1990): 90–95.Bremer, Brandon, Lorenzo Wu, Zoran Josipovic, and colleagues. “Mindfulness Meditation Increases Default Mode, Salience, and Central Executive Network Connectivity.” Scientific Reports 12 (2022).Brewer, Judson A., Patrick D. Worhunsky, Jeremy R. Gray, Yi-Yuan Tang, Jochen Weber, and Hedy Kober. “Meditation Experience Is Associated with Differences in Default Mode Network Activity and Connectivity.” Proceedings of the National Academy of Sciences 108, no. 50 (2011): 20254–20259.Britton, Willoughby B. and colleagues. Research associated with the “Varieties of Contemplative Experience” project on meditation-related challenges, adverse effects, and safety considerations in contemplative practice.Crowley, Aleister. Liber E vel Exercitiorum sub figura IX. In the A∴A∴ training corpus. Relevant sections include asana, pranayama, and dharana as foundational magical exercises.Dennison, Paul. “Insights From an EEG Study of Buddhist Jhāna Meditation.” Frontiers in Human Neuroscience 13 (2019).Fialoke, Shantala, Helen Weng, and colleagues. “Functional Connectivity Changes in Meditators and Novices During Yoga Nidra Practice.” Scientific Reports 14 (2024).Fox, Kieran C. R., Savannah Nijeboer, Matthew L. Dixon, James L. Floman, Melissa Ellamil, Samuel P. Rumak, Peter Sedlmeier, and Kalina Christoff. “Is Meditation Associated with Altered Brain Structure? A Systematic Review and Meta-analysis of Morphometric Neuroimaging in Meditation Practitioners.” Neuroscience & Biobehavioral Reviews 43 (2014): 48–73.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43.Kozhevnikov, Maria, Olesya Louchakova, Zoran Josipovic, and Michael A. Motes. “The Enhancement of Visuospatial Processing Efficiency Through Buddhist Deity Meditation.” Psychological Science 20, no. 5 (2009): 645–653.Kozhevnikov, Maria, John A. Elliott, Jennifer Shephard, and Klaus Gramann. “Neurocognitive and Somatic Components of Temperature Increases During g-Tummo Meditation: Legend and Reality.” PLOS ONE 8, no. 3 (2013): e58244.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217.Lomas, Tim, Juan Carlos Ivtzan, and Itai K. Fu. “A Systematic Review of the Neurophysiology of Mindfulness on EEG Oscillations.” Neuroscience & Biobehavioral Reviews 57 (2015): 401–410.Lott, James P., Richard J. Davidson, John D. Dunne, Thupten Jinpa, Antoine Lutz, and colleagues. “No Detectable Electroencephalographic Activity After Clinical Declaration of Death Among Tibetan Buddhist Meditators in Apparent Tukdam.” Frontiers in Psychology 11 (2021): 599190.Lutz, Antoine, Lawrence L. Greischar, Nancy B. Rawlings, Matthieu Ricard, and Richard J. Davidson. “Long-term Meditators Self-induce High-amplitude Gamma Synchrony During Mental Practice.” Proceedings of the National Academy of Sciences 101, no. 46 (2004): 16369–16373.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLoS ONE 3, no. 3 (2008): e1897.Matko, Karin, Peter Sedlmeier, and colleagues. “Adverse Effects of Meditation and Mindfulness in Clinical Practice.” 2025.Patanjali. Yoga Sutras. Especially Book III, traditionally describing dharana, dhyana, and samadhi.Riegner, Gretchen, Fadel Zeidan, and colleagues. “Disentangling Self from Pain: Mindfulness Meditation-Induced Pain Relief Is Driven by Thalamic-Default Mode Network Decoupling.” Pain 164, no. 2 (2023): 280–291.Tang, Yi-Yuan, Britta K. Hölzel, and Michael I. Posner. “The Neuroscience of Mindfulness Meditation.” Nature Reviews Neuroscience 16 (2015): 213–225.Vago, David R., and David A. Silbersweig. “Self-awareness, Self-regulation, and Self-transcendence: A Framework for Understanding the Neurobiological Mechanisms of Mindfulness.” Frontiers in Human Neuroscience 6 (2012): 296.Zeidan, Fadel, and colleagues. Research on mindfulness meditation, pain modulation, attention, and the neural mechanisms of pain relief.Slagter, Heleen A., Antoine Lutz, Lawrence L. Greischar, Andrew D. Francis, Sander Nieuwenhuis, James M. Davis, and Richard J. Davidson. “Mental Training Affects Distribution of Limited Brain Resources.” PLOS Biology 5, no. 6 (2007): e138. Use for: Attentional blink, limited attention, and meditation changing how the brain allocates resources.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43. Use for: Neuroplasticity, repeated practice leaving measurable marks on the brain, and the “practice writes itself into the practitioner” idea.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217. Use for: Predictive processing, the brain as a prediction machine, meditation loosening automatic models, and the “veil” argument.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLOS ONE 3, no. 3 (2008): e1897. Use for: Compassion meditation, loving-kindness, emotional circuitry, and training compassion as a repeatable state rather than just a moral idea.Kok, Bethany E., Kimberly A. Coffey, Michael A. Cohn, Lahnna I. Catalino, Tanya Vacharkulksemsuk, Sara B. Algoe, Marc A. Brantley, and Barbara L. Fredrickson. “How Positive Emotions Build Physical Health: Perceived Positive Social Connections Account for the Upward Spiral Between Positive Emotions and Vagal Tone.” Psychological Science 24, no. 7 (2013): 1123–1132. Use for: Loving-kindness, social connection, vagal tone, and the cautious “social nervous system” bridge.Black, David S., and George M. Slavich. “Mindfulness Meditation and the Immune System: A Systematic Review of Randomized Controlled Trials.” Annals of the New York Academy of Sciences 1373, no. 1 (2016): 13–24. Use for: Immune-system caution, inflammation markers, cell-mediated immunity, biological aging, and why this material should be framed as tentative rather than miracle healing.Burić, Ivana, Miguel Farias, Jonathan Jong, Christopher Mee, and Inti A. Brazil. “What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices.” Frontiers in Immunology 8 (2017): 670. Use for: Stress biology, inflammatory gene expression, NF-kB-related language, and the cautious claim that mind-body practices may affect biology below ordinary mood.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Why are more people becoming afraid of vaccines than the diseases vaccines were created to prevent? The answer is not simply a lack of information. In many ways, vaccines have become victims of their own success.For decades, widespread vaccination helped push diseases like measles, polio, pertussis, and smallpox out of everyday life. Many of us no longer live with the visible fear of these infections, their complications, or the way they can destabilize families, communities, and healthcare systems.But when the disease feels distant, the vaccine can start to feel like the bigger threat.That shift is now changing public health.Rather than assuming vaccine hesitancy is only about ignorance or defiance, we need to look more carefully at:• why people can become more suspicious of vaccines when they no longer see the diseases vaccines helped control• How misinformation, fear, personal experience, politics, history, and social media can shape health decisions• Why highly educated people can still be vulnerable to vaccine misinformation• how confusing a side effect, adverse event, or normal immune response with a true allergy can create long-term fear• Why egg allergy is no longer the vaccine barrier many people still believe it is• And how declining vaccination rates can allow diseases like measles and pertussis to reemergeVaccine education has to move beyond simply telling people what to do. We need clearer, more compassionate conversations that acknowledge fear while helping people separate facts from fiction.In this upcoming episode, I'm joined by Dr. Joyce Yu, associate professor of pediatrics and director of the Food Allergy Program at Columbia University Irving Medical Center.Together, we explore:What is driving the rise of vaccine hesitancyWhy vaccine-preventable diseases can return when communities let their guard downHow allergists help patients understand whether a vaccine reaction is truly an allergyAnd why rebuilding trust requires listening, clarity, and evidence-based conversationIf you or someone you love has ever felt uncertain, afraid, or confused about vaccines, allergic reactions, side effects, or conflicting health information, this conversation offers a grounded look at how fear spreads, how misinformation takes hold, and why protecting public health depends on rebuilding trust.Guest BioDr. Joyce Yu is an associate professor of pediatrics and director of the Food Allergy Program at Columbia University Irving Medical Center. She is an allergy and immunology specialist with clinical and scientific expertise in food allergy, immunology, vaccine-related concerns, and immune system function. Dr. Yu received her medical education at the Icahn School of Medicine at Mount Sinai, completed her residency at Northwestern/Lurie Children's Hospital, and completed her fellowship in Allergy and Immunology at Mount Sinai. Her postdoctoral work focused on toll-like receptor signaling and memory B cell development, mechanisms that are closely connected to how the immune system develops lasting protection. She is a fellow of both the American College of Allergy, Asthma & Immunology and the American Academy of Allergy, Asthma & Immunology. She is also a former president of the New York Allergy and Asthma Society and has held leadership roles within the Clinical Immunology Society. Connect with Dr. Yu on LinkedIn.About Your HostHosted by Dr. Deepa Grandon, MD, MBA, a triple board-certified physician with over 23 years of experience working as a Physician Consultant for influential organizations worldwide. Dr. Grandon is the founder of Transformational Life Consulting (TLC) and an outspoken faith-based leader in evidence-based lifestyle medicine.Disclaimer ​​TLC is presenting this podcast as a form of information sharing only. It is not medical advice or intended to replace the judgment of a licensed physician. TLC is not responsible for any claims related to procedures, professionals, products, or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services, or methods that might be referenced.Work With Me Learn More About My Soon-to-Launch Telemedicine PlatformExciting news. My virtual medical platform is launching soon! If you're looking for personalized, evidence-based care in allergy, immunology, and lifestyle medicine, stay tuned.Visit drdeepa-tlc.org and click on “Learn More” to join the waitlist and be the first to receive updates about services, membership options, and launch details.Precision care. Personalized guidance. Wherever you are.DevotionalsWant to receive a devotional every week from Dr. Deepa? Devotionals are dedicated to providing you with a moment of reflection, inspiration, and spiritual growth each week, delivered right to your inbox. Visit drdeepa-tlc.org to subscribe for free.Trauma CoursesReady to deepen your understanding of trauma and kick-start your healing journey? Explore a range of online and onsite courses designed to equip you with practical and affordable tools. From counselors, ministry leaders, and educators to couples, parents, and individuals seeking help for themselves, there's a powerful course for everyone. Browse all the courses now to start your journey.

Martha Alexander-Miller discusses why newborn and infant immune responses to vaccines are generally less effective and how we can make vaccines safer and more effective. Host: Cindy Leifer Guest: Martha Alexander-Miller Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Flu HA nanoparticle vaccine (Nat Comm, 2025) Sex-dependent adjuvant activity in newborns (Vaccines, 2024) Flu vaccine with R848 adjuvant (Vaccines, 2023) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.  

Support the Institute today. https://givenow.nova.edu/the-institute-for-neuro-immune-medicine-inim-2025   In today's episode, Haylie Pomroy is joined by Dr. Theoharis Theoharides, one of the world's leading authorities on mast cell biology and neuroimmunology, to reframe multiple chemical sensitivity as a measurable, physiological immune response rooted in mast cell activation. Dr. Theoharides explains how mast cells throughout the body and brain respond to environmental chemicals, stress hormones, fragrances, mold toxins, and other triggers by releasing hundreds of chemical mediators that can affect every organ system simultaneously. He outlines the specific labs and biomarkers worth requesting, why standard diagnostic pathways frequently miss this condition, and what patients can do right now to reduce mast cell reactivity through natural compounds, environmental modifications, and targeted testing. This is a conversation that gives patients the clinical language and tools they need to stop being dismissed and start getting answers. Tune in to Hope and Help For Fatigue and Chronic Illness. Dr. Theoharis Theoharides is a Professor, Vice Chair of Clinical Immunology, and Director at the Institute for Neuro-Immune Medicine-Clearwater, an Adjunct Professor of Immunology at Tufts School of Medicine, where he was a Professor of Pharmacology and Internal Medicine, and also the  Director of Molecular Immunopharmacology & Drug Discovery, and Clinical Pharmacologist at the Massachusetts Drug Formulary Commission (1983-2022). He received his BA, MS, MPhil, PhD, and MD degrees and the Winternitz Price in Pathology from Yale University and received a Certificate in Global Leadership from Tufts Fletcher School of Law and Diplomacy and a Fellowship at Harvard Kennedy  School of Government. He trained in internal medicine at New England Medical Center, which awarded him the Oliver Smith Award, "recognizing excellence, compassion, and service." Dr. Theoharides has 485 publications (46,491 citations; h-index 106), placing him in the world's top 2% of most cited authors, and he was rated the worldwide expert on mast cells by Expertscape. He was inducted into the Alpha Omega Alpha National Medical Honor Society, the Rare Diseases Hall of Fame, and the World Academy of Sciences.   Website: https://www.drtheoharides.com LinkedIn: linkedin.com/in/theoharis-theoharides-ms-phd-md-faaaai-67123735 Instagram: https://www.instagram.com/dr.theoharides/   Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.   Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com   Instagram: https://www.instagram.com/hayliepomroy  Facebook: https://www.facebook.com/hayliepomroy  YouTube: https://www.youtube.com/@hayliepomroy/videos  LinkedIn: https://www.linkedin.com/in/hayliepomroy/  X: https://x.com/hayliepomroy    Thank you for tuning in to the Hope and Help For Fatigue and Chronic Illness Podcast. Sign up today for our newsletter.

We are continuing our series of interviewing thought leaders in the field of allergy and immunology. Dr. Gupta and Kortney sit down with Dr. Carla Davis, the president of the American Academy of Allergy, Asthma and Immunology. What we cover in this episode about Dr. Davis and the AAAAI What the AAAAI is and why it matters to patients. A 7,000-member organization working behind the scenes to support allergy and immunology care across the US and around the world. Dr. Davis's path to the presidency. From her early experiences advocating as a fellow to her major pivot from Baylor to Howard University, the journey that shaped her priorities. Initiative: AAAAI Advocate. A new platform connecting patients and physicians directly to their legislators, making it easy to share your story and push for better access to allergy care. Initiative: AAAAI AI Task Force. A dedicated group bringing AI tools into allergy care, including AAAAI Ignite, a Netflix-style platform that helps members find and curate personalized allergy content. Initiative: The Collaborative Translational Mechanistic Research Seed Award. A $100,000 grant pairing laboratory scientists with clinical allergists to move new discoveries directly into patient care. More resources American Academy of Allergy, Asthma and Immunology AAAAI Advocate platform Allergy & Asthma Network health equity resources   This podcast is made in partnership with the Allergy & Asthma Network.  

In this episode, we are joined by Dr. Francisco Uzal, an internationally recognized veterinary pathologist and a global leader in pathology education. He is a professor in Pathology, Microbiology, and Immunology at the University of California, Davis, and Branch Chief at the California Animal Health and Food Safety Diagnostic Lab. Dr. Uzal has spent more than four decades in academic diagnostic pathology and is the CEO of the Davis Thompson Foundation, the world's largest organization dedicated to teaching veterinary and comparative pathology.  Join us as we learn more about Dr. Uzal's career, shaped by international collaboration, mentorship, and service. He is especially known for his work in diagnostic pathology and clostridial diseases, as well as for expanding access to education. Most importantly, Dr. Uzal is a passionate educator and advocate for the global pathology community, and we're thrilled to have him with us today. So stay right here for our conversation with Dr. Francisco Uzal.  ____ Links ACVP Errors in Publication Portal 2026 ACVP Annual Meeting  ____ ACVP Social Media Facebook - ACVP Meetings and Topics Instagram - americancollegevetpath X (Twitter) - @ACVP LinkedIn - AMERICAN COLLEGE OF VETERINARY PATHOLOGISTS ____ Music: Guestlist by Podington Bear, licensed under an Attribution-NonCommercial 3.0 International License.  The contents of this audio do not necessarily reflect the opinions of the American College of Veterinary Pathologists (ACVP) or the participants' affiliations. Spoken audio content and associated photos are the property of the American College of Veterinary Pathologists, 2026. 

When it comes to treating chronic sinus disease with nasal polyps…what's the best approach, surgery or biologics?Well, the answer is it's usually not either-or anymore.When patients are trying to manage these challenging conditions, some people opt for one or the other. But more physicians are finding that surgery and biologics aren't different paths. They are actually treatment protocols that complement each other.Surgery may remove the growths, but it doesn't necessarily stop the process of creating them in the first place. Biologics may suppress the inflammatory pathways driving recurrence, but they don't physically restore blocked sinus anatomy or remove bulky disease.We're entering a new phase of care where the question is no longer “surgery or biologics?” but how both can work together as part of a personalized strategy.Instead of treating every patient the same way, physicians are now looking deeper at the inflammatory pathways driving disease, recurrence risk, quality of life, and even how different biologics target different parts of the immune cascade.The shift is moving chronic sinus care away from a one-size-fits-all model and toward precision medicine that's designed around the individual patient.In this episode, I'm joined by Dr. Tassos Hantzakos, staff physician in otolaryngology and residency program director at Cleveland Clinic Abu Dhabi, and Dr. Deepa Sheth, allergy and immunology specialist.Together, we break down how the treatment landscape for chronic rhinosinusitis with nasal polyps is evolving, why collaboration between ENT and allergy specialists is becoming essential, and how biologics are reshaping the future of inflammatory airway disease management.Things You'll Learn In This Episode Not just a surgical problemFor decades, treatment focused on physically removing nasal polyps, but many patients still experienced recurrence. Why does surgery alone often fail to stop the disease?Biologics are changing how we think about airway diseaseNew biologic therapies are targeting different parts of the inflammatory cascade. How do physicians decide which biologic is the best fit for a specific patient?The future of treatment is collaborative, not competitiveThe conversation is shifting away from “surgery versus biologics” toward integrated care between ENT surgeons and allergists. When should surgery come first, and when should biologics be introduced?Precision medicine is reshaping chronic inflammatory careDifferent patients may require different treatment approaches. How does identifying the root inflammatory driver completely change long-term management outcomes?Guest BioDr. Tassos Hantzakos is a staff physician in the Otolaryngology Department at Cleveland Clinic Abu Dhabi's Integrated Surgical Institute, where he also serves as Program Director of the Otolaryngology Residency. His clinical expertise spans otolaryngology, rhinology, phonosurgery, laryngeal laser surgery, and voice disorders. Before joining Cleveland Clinic Abu Dhabi, Dr. Hantzakos served as a consultant within the Hellenic National Health System, Director of the Voice Clinic at NUKA, and Clinical Associate Professor at Cleveland Clinic Lerner College of Medicine in the US. He has contributed to numerous international journal articles and textbooks and is actively involved in several professional societies, including the European Laryngological Society, the International Association of Phonosurgeons, the Voice Foundation, and the European Society for Swallowing Disorders. Outside of medicine, he enjoys spending time with his family, long-distance running, triathlons, and playing guitar and drums. Connect with him on LinkedIn. Dr. Dipa K. Sheth is an allergist-immunologist based in Washington, DC, and an Assistant Professor of Medicine at Uniformed Services University of the Health Sciences. Her clinical work focuses on allergy and immunology, with experience treating conditions such as chronic sinusitis, rhinitis, atopic dermatitis, drug hypersensitivity, and food hypersensitivity. Dr. Sheth received her medical degree and completed her internal medicine training at George Washington University, followed by a fellowship in Allergy and Immunology at the University of Colorado School of Medicine and National Jewish Health. Her research has been published in journals including Frontiers in Allergy and Current Opinion in Allergy and Clinical Immunology. Connect with her on LinkedIn. About Your HostHosted by Dr. Deepa Grandon, MD, MBA, a triple board-certified physician with over 23 years of experience working as a Physician Consultant for influential organizations worldwide. Dr. Grandon is the founder of Transformational Life Consulting (TLC) and an outspoken faith-based leader in evidence-based lifestyle medicine.Disclaimer ​​TLC is presenting this podcast as a form of information sharing only. It is not medical advice or intended to replace the judgment of a licensed physician. TLC is not responsible for any claims related to procedures, professionals, products, or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services, or methods that might be referenced.Work With Me Learn More About My Soon-to-Launch Telemedicine PlatformExciting news. My virtual medical platform is launching soon! If you're looking for personalized, evidence-based care in allergy, immunology, and lifestyle medicine, stay tuned. Visit drdeepa-tlc.org and click on “Learn More” to join the waitlist and be the first to receive updates about services, membership options, and launch details.Precision care. Personalized guidance. Wherever you are.Devotionals Want to receive a devotional every week from Dr. Deepa? Devotionals are dedicated to providing you with a moment of reflection, inspiration, and spiritual growth each week, delivered right to your inbox. Visit drdeepa-tlc.org to subscribe for free.Trauma Courses Ready to deepen your understanding of trauma and kick-start your healing journey? Explore a range of online and onsite courses designed to equip you with practical and affordable tools. From counselors, ministry leaders, and educators to couples, parents, and individuals seeking help for themselves, there's a powerful course for everyone. Browse all the courses now to start your journey.

Anurag Singh MD, PhD. is a physician, researcher, immunologist, and one of the leading voices behind the science of Urolithin A – a gut microbiome metabolite. Urolithin A is crucial for mitochondrial health by stimulating mitophagy. Dr. Singh breaks down the science and explains his extensive research into how this postbiotic compound could play a major role in cellular energy and longevity. Whether you’re an athlete, a health optimizer, or just curious about the future of longevity science, this conversation with Dr. Anurag Singh is packed with cutting-edge, evidence-based insights you won’t want to miss. Today on The Lab Report: 3:05 Meet Dr. Anurag Singh and learn about Urolithin A 6:45 Substrates, prevalence, and specific gut commensal bacteria 9:40 Mitophagy and mitochondrial health 12:55 Immunology and aging 15:35 Urolithin A and muscle mass 17:45 Academic research a-ha moments 20:15 Clinical benefits of Urolithin A 23:00 Food based approach vs. supplementation 25:25 Safety and contraindications 27:00 Ranking your supplement stack 29:10 The Fireball Additional Resources: Timeline Mitopure Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on X, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

You're welcome. Because today, we're digging into something I bet you're seeing on your back porch right now, and nobody is talking about it. Asthma and speech sound disorders. If you have a child on your caseload with significant asthma, this episode is the one you need tomorrow. Roll up your sleeves with me. We're going to get our hands really, really dirty, and we're going to talk about where the research stops and where the practitioner begins. Because this is where you have to have skin in the game. This is where it matters that you know your little professors closely, that you study what's happening under your own magnifying glass. Here's what we cover: What the research tells us. A Northwestern-led study of 337,285 children found that asthma, hay fever, and food allergy are significantly associated with speech disorders, and the more severe the disease, the greater the risk (Strom & Silverberg, 2016, Pediatric Allergy and Immunology). A 2006 population-based study of 7,389 eight-year-old children identified asthma as one of the factors associated with voice disorders (Carding et al., 2006, Journal of Voice). So we know there is a connection. And that is where the research stops. What I'm seeing on my back porch. This is where things get gnarly. The children with significant asthma are breaking the rules of speech development. They're stopping fricatives, they're fronting velars, they're voicing voiceless sounds, and they're deleting the /h/. Looks like phonological processes, right? Except phonological processes happen across positions of words. What I'm seeing with these kiddos is 0% accuracy in the initial position of words and 100% accuracy in the medial and final positions. That is not linguistic. Do you dare disturb the universe? Yes, you do. That's physiology. Why this is happening. My hypothesis, and this is practitioner experience, not research on large populations, is that these children have insufficient subglottal air pressure. Continuant sounds need continuous airflow from the respiratory system. After the vowel gets going, the vocal folds are doing the work and producing those sounds becomes easy. But in the initial position of words, when you're starting cold, you don't have that help. So fricatives stop, velars front, voiceless sounds get voiced, and the /h/ gets deleted. What the child is telling you. Mouth breathing at rest. Chin jutting. Head forward to get more air in. Tense neck and visible effort while speaking, like they're yelling at conversational volume. Fluctuating accuracy that tracks with allergy season and asthma flare-ups. The clear boogers come out and suddenly the phonological processes you thought were suppressed come right back. That is not a child regressing. That is a child without the respiratory support to do the work in initial position. What to do differently (DSD). You've been doing best practice. You're doing the complexity approach, you're doing DTTC, you're doing multimodal cueing, you're holding the 80% challenge point. And you're still at 0% in initial position. So we're going to do something different. We're going to capitalize on what the child can do. They can produce these sounds after a vowel, so we anchor with a vowel. We say "a sun, a sun." Or we use the end of one word to start the next, "yes sun, yes sun." And then over time, we stretch the pause longer and longer until that target is sitting in the initial position of the word on its own. That is how we DSD. This is one to take notes on. And if you have one of these kiddos on your back porch right now, shoot me an email. This is exactly the kind of clinical pattern I want to research next.

Dr. Deb Muth 00:04What if the future of healing isn’t about replacing cells, but about teaching your body how to heal itself again? We keep hearing the words stem cells and exoomes thrown around like they’re interchangeable, but they’re not. One is regulated, controversial, and often misunderstood. The other is rapidly emerging as one of the most exciting communication systems in human biology. Dr. Deb Muth 00:33And here’s the real question no one’s asking. Are we actually regenerating tissue or are we just stimulating the body to remember how it used to heal? Tired of being told your labs are normal, but you still feel terrible? At Serenity Healthcare Center, we don’t chase symptoms. We find the root cause. hormones, gut health, autoimmune conditions, chronic fatigue, brain fog. Dr. Deb Muth 01:02We use cuttingedge functional and regenerative medicine to get you real answers and a real path forward. This isn’t your average doctor’s office. This is medicine the way it was meant to be practiced. You deserve to feel like yourself again. Visit serenityhealthcarecenter.com to book your appointment today. Let us help you heal from the inside out. Dr. Deb Muth 01:28Welcome back to Let’s Talk Wellness Now. I’m Dr. Deb, your host. And if you’ve been following regenerative medicine, you’ve probably noticed the confusion. Patients are asking me every week, are exoomes stem cells? Are stem cells legal in the United States? I heard the FDA is shutting down all these clinics. Can I even get this therapy? Do I have to leave the country for treatment? Today, we’re cutting through the noise. This episode is not hype. Dr. Deb Muth 01:54It’s not sales. It’s education so you can understand the science, the regulatory reality, and the clinical difference between stem cell therapy and exoome therapy. And here’s what I want you to know right up front. Yes, these therapies are being used in the United States every single day. Yes, they’re being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 02:22Some are being used in FDA registered clinical trials. Some are being used in observational studies and some are being used in clinical practice under physician discretion. The landscape is nuanced and you deserve to understand it. So, grab your cup of coffee or tea and settle in for a deep dive into the most understood therapies in regenerative medicine. Dr. Deb Muth 02:43what they actually are, how they work, the regulatory landscape, and how they might support your body’s natural healing capacity. Let’s talk wellness now. So, let me start by asking you something. When you hear the word stem cell, what do you picture? Most people imagine damaged tissues magically regenerating or a torn meniscus growing back, cartilage reforming it into an arthritic joint or damaged brain tissue being replaced with healthy new beautiful cells. It’s a beautiful vision. Dr. Deb Muth 03:15And while it’s not quite that simple, the reality is actually more sophisticated and honestly more beautiful. Stem cells are powerful and they absolutely work, but the way they work and the mechanism by which they support healing is far more elegant and more so than most people really understand. And if you’re going to invest in regenerative therapy, you deserve to understand what you’re actually receiving. Dr. Deb Muth 03:44So, let’s start at the beginning. What are stem cells? At their core, stem cells are undifferentiated cells. That means they haven’t yet decided what they want to be when they grow up. Unlike a heart cell or a skin cell or a bone cell which have already committed to a specific function, stem cells exist in this beautiful state of potential. Dr. Deb Muth 04:05They have two remarkable abilities. First, they can self-renew. They can make copies of themselves, maintaining a reserve of these powerful cells throughout your lifetime. Second, they can differentiate under the right conditions. They can transform into specialized cell types. Bone cells, cartilage cells, nerve cells, muscle cells, even blood cells. Dr. Deb Muth 04:27This is why they’ve captured the imagination of the medical world. The potential is extraordinary. Now, there are several types of stem cells and understanding the differences matters tremendously for both understanding how they work and understanding how they’re regulated. Adult mezzenymal stem cells. We call these MSC’s are the most commonly used regenerative medicine. Dr. Deb Muth 04:54These come from bone marrow, atapost tissue, that’s fat, and other adult sources. They’re what we can call multi-potent, meaning they can become several types of cells, but not every type. A bone marrow stem cell isn’t going to become a brain cell, for instance. It has potential but it’s directed potential. Dr. Deb Muth 05:19Then we have perinatal stem cells. These come from umbilical cord blood cord tissue or something called Wharton’s jelly which is the gelatinous substance inside the umbilical cord. These cells are younger, more potent, and research by Weiss and colleagues published in stem cells back in 2006 showed that Wharton’s jelly derived MSC’s have superior proliferation and differentiation potential compared to bone marrow derived cells. Dr. Deb Muth 05:48They’re like comparing a 20-year-old athlete to a 50-year-old athlete. Both can perform, but one has more reserve capacity, more vigor, and more regenerative potential. And this isn’t this is very important because the perinatal sources umbilical cord tissue Wharton’s jelly amniotic tissue these are what many regenerative medicine clinics in the United States are using today and they’re using them because these tissues are incredibly rich in not just stem cells but growth factors cytoines and exoomes. Dr. Deb Muth 06:21Then there are embryionic stem cells. These are pur potent and they become any cell type in the body, but they’re highly regulated, ethically controversial, and honestly, they’re not being used in clinical practice in the United States outside of the very specific FDA approved research trials. Dr. Deb Muth 06:41So, when clinics talk about stem cell therapy, they’re almost never talking about embryionic stem cells. Now, here’s where it gets interesting and this is the part that changes everything about how we understand regenerative medicine. When you receive stem cell therapy, let’s say someone injects umbilical cord derived messenymal stem cells into your arthritic knee, those cells do not typically engraft or become new tissue in any permanent way. Dr. Deb Muth 07:12They don’t set up shop in your joint and start cracking out new cartilage cells for the rest of your life. So what are they actually doing then? Well, in 2011, researchers Arnold Arnold Kaplan and Dennis Korea published a landmark paper in stem cells translational medicine that fundamentally changed how we understand MSC therapy. Dr. Deb Muth 07:35They proposed that we should stop calling memal stem cells and start calling them medicinal signaling cells. Why? Well, because their primary therapeutic benefit doesn’t come from what they become. It comes from what they secrete. Think of stem cells as incredibly sophisticated biological pharmacies. When you inject them into damaged tissue, that arthritic knee, that inflamed autoimmune condition, that injured brain, that don’t just sit there passively, they sense the environment. Dr. Deb Muth 08:07They detect inflammation. They recognize the tissue damage and they understand that the immune dysregulation is present and they see that and respond. They start pumping out hundreds of bioactive molecules, growth factors that tell your cells to repair and rebuild, cytoines that modulate inflammation, chemocines that recruit your body’s own healing cells to the area. Dr. Deb Muth 08:32And these tiny membranes bound packages called extracellular vesicles, including exosomes, which we’re going to talk about extensively today as well. These secreted factors are giving instructions to your native cells. They’re saying, “Let’s reduce inflammation. Let’s modulate your immune response. Let’s promote angioenesis. Dr. Deb Muth 08:53” That’s the formation of new blood vessels, bringing nutrients and oxygen. Let’s stimulate your own resident stem cells to wake up and get to work. Reduce cell death in damaged tissue and restore normal cellular function. This is called paracrine signaling. It’s the cellto cell communication. And this is where the real therapeutic power lives. Dr. Deb Muth 09:14The stem cells themselves, many of them die within days to weeks, but the cascade of healing they trigger, the signals they send, the programs they activate in your own cells, those effects can last for months or even years. Now, this understanding is crucial because it explains why both stem cell therapy and exoo therapy can be effective. Dr. Deb Muth 09:38The stem cells are powerful not because they become new tissue but because of the signals they send and exoomes are those signals isolated and concentrated. The biggest misconception in regenerative medicine is that stem cells replace tissue and in reality they coach healing more than they become healing. They’re biological educators teaching your body to remember how it used to heal before chronic inflammation, toxicity, and disease turned off all those programs. Dr. Deb Muth 10:12So if stem cells don’t exactly end graft and become the new tissue, if their power is in their signaling and then next logical question is why do we need the cells at all? Well, if we could isolate the messengers themselves, what if we could deliver just the communication systems without any of the complexity of the living cells? Well, that’s exactly what exosomes are. Dr. Deb Muth 10:38And they represent the cutting edge of regenerative medicine. So, let me paint you a picture of how cells actually communicate. Because for most medical history, we had it wrong. For decades, textbooks taught us that cells talk to each other in two basic ways. through direct contact like shaking hands or releasing signaling molecules that floated through the extracellular space like messages in bottles, simple chemical messages. Dr. Deb Muth 11:09But in the 1980s and 90s, researchers started discovering something far more sophisticated. cells were releasing these tiny membrane bound packages like a biological FedEx envelope kind of you know it was filled with complex specific cargo and these packages could travel through the blood cross the barriers that normally keep things out like bloodb brain barrier and deliver their contents to distant cells with remarkable precision. Dr. Deb Muth 11:38These are called extracellular vesicles. And exoomes are one of the most therapeutic important types. So what exactly are exosomes? Well, they’re nanosized vesicles, typically 30 to 150 nanome in diameter. To put that into perspective, a human hair is about 100,000 nanometers wide. These are incredible and most impossibly tiny. Dr. Deb Muth 12:09They’re released by virtually all cells in the body, but the most therapeutically interesting exoomes come from mezenymal stem cells. And those medicinal signaling cells we just discussed. And according to a landmark review of Raposo and Stervogal, they published in the journal of cell biology in 2013, exoomes are not cellular debris. They’re not waste products. Dr. Deb Muth 12:35They are precisely engineered communication vesicles or vehicles. Think of them as sophisticated delivery systems carefully packed, carefully labeled, and sent to specific destinations. very specific instructions. Inside each of these exoomes, you’ll find an incredibly sophisticated payload. They are microRNAs. These are small RNA molecules that can literally turn genes off or on in the recipient cells. Dr. Deb Muth 13:06They can tell a cell to start making more collagen, to reduce inflammatory proteins, to activate repair programs that have been shut down by chronic disease for a very long time. There are messenger RNAs, actual templates for protein production. And exoome can deliver these instructions for making healing proteins. There are proteins themselves, growth factors, cytoines, enzymes, all the molecular tools a cell needs to heal. Dr. Deb Muth 13:34And there are lipids, specialized fats that help the exoome membrane fuse with targeted cells, delivering the cargo inside. When an exoome reaches its target cell, it can either fuse the cell membrane and deliver its contents directly inside like a Trojan horse, or it can bind to surface receptors and trigger signaling cascades, setting off a chain reaction of healing responses. Dr. Deb Muth 14:01Either way, it’s delivering very specific targeted instruction. And here’s what makes this so powerful. Those instructions are tailored to what this recipient cell actually needs. So, let me give you some concrete examples of what the research actually shows because this is where it really gets exciting. When researchers inject MSC derived exoomes into hearts that had experienced eskeeia, reprofusion, injury, that’s damaged blood flow being cut off and then being restored. Dr. Deb Muth 14:36Kind of like what happens during a heart attack. Something remarkable happened. A study by Lei and colleagues published in stem cell research in 2010 showed that exoomes significantly reduced the size of the damaged area, reduced inflammatory cytoines that drive tissue destruction and promoted tissue repair signaling. The exoomes were telling the heart cells stop the inflammatory cascade, activate your survival programs and repair the damage. Dr. Deb Muth 15:06In cartilage research, tow and colleagues published work in biioaterials in 2017 showing that exosomes derived from MSC’s could promote cartilage regeneration in osteoarthritis models. And the exoomes carried specific microRNAs that told condondroytes cartilage cells to proliferate and make more extracellular matrix, the structural framework of healthy cartilage. Dr. Deb Muth 15:30for autoimmune conditions. Research by Blazic and colleagues in Frontiers in Immunology in 2014 demonstrated that MSC derived exoomes could shift immune cell behavior from pro pro-inflammatory to regulatory. They could take an overactive self-attacking immune system and restore balance and promote tolerance. And perhaps most exciting brain research, a study by Zinn and colleagues published in the journal of extracellular vesicles in 2013 showed that MSC derived exoomes could cross the bloodb brain barrier. Dr. Deb Muth 16:07That protective shield around your brain that normally keep things out and promote neurological recovery in stroke models. They reduced brain inflammation, promoted neuroplasticity, supported the formation of neural connections, and for mitochondrial dysfunction, which underlies so many chronic conditions, Morrison and colleagues published research and scientific reports in 2017 showing that MSC derived exoomes can actually deliver functional mitochondria or mitochondrial components to damaged cells. They’re not Dr. Deb Muth 16:40just sending instructions, they’re sending spare parts. They’re restoring the cellular powerhouses to produce energy. So why are exoomes fundamentally different from stem cells? Well, exoomes contain no living cells. They can’t replicate. They can’t end graph. And they have virtually no risk of immune rejection or tumor formation. Dr. Deb Muth 17:03Concerns that exist elevate rarely with cellular therapies. They’re essentially biological software updates for your cells. As Fineian Pitiger wrote in their seinal review in stem cells in 2017, MSC derived exoomes represent the active ingredient of stem cell therapy delivered in a cellfree format. That’s the key insight in the in the therapeutic benefit of stem cells and it comes from what they excrete. Dr. Deb Muth 17:33Then exoomes are the secretion isolated, concentrated, and standardized. From a practical clinical standpoint, exoomes offer several compelling advantages. First, consistency. Because exoomes can be isolated, characterized, and standardized, each dose can be remarkably consistent. With living stem cells, there’s variability based on donor age, health status, processing methods, and one batch may be robust, but another might be weaker. Dr. Deb Muth 18:05With exoomes, you can measure the content, measure the potency, and ensure the quality control. Second is storage. Exoomes can be liophalized. They can be freeze-dried and stored at room temperature or refrigerated for extended periods. Stem cells require cryopreserv preservation, careful freezing, careful thawing. They’re fragile. Dr. Deb Muth 18:31Exoomes are remarkably stable. And third, their safety profile. Without living cells, the risk of adverse imunological reactions is dramatically lower. You’re not introducing foreign cells that your immune system might recognize and attack. You’re introducing molecular messages. Fourth is scalability. You can harvest millions, even billions of exoomes from stem cell cultures without ever injecting the cells themselves. Dr. Deb Muth 19:01And you can produce large quantities, standardize them, and make them available to patients. Now, there is a caution here in doing this. The scalability can produce rogue cells, and we want to be cautious of that. So, here’s what I need you to understand. Exoomes don’t force healing. They remind the body how healing works. Dr. Deb Muth 19:24They’re not replacing damaged cells. They’re re-educating the cells you already have. They’re turning back time on the biological programs that got turned off by inflammation, toxicity, trauma, time, and chronic disease. Your body knows how to heal. It’s done its entire life. Every cut that closed, every bone that mended, every infection you fought off, your body orchestrated that healing. Dr. Deb Muth 19:51The problem is that chronic disease, chronic inflammation, toxic exposures, poor nutrition, stress, all of these things disrupt the communication networks that coordinate healing. And exoomes restore that communication. They’re like rebooting a computer that’s frozen. They reset the system and remind it how it’s supposed to function. All right. Dr. Deb Muth 20:14So, this would not be complete if we didn’t talk about regulation because this is where a lot of confusion exists. And I want you to be given a real picture. Not fear-mongering, not pretending. There aren’t regulatory considerations, but the actual practical reality of how regenerative medicine is practiced in the United States today. Dr. Deb Muth 20:38Here’s what you need to understand. The FDA regulates these therapies and they have specific frameworks, but there’s important nuances between regulatory text enforcement priorities and actual clinical practice. And there are also state level regulations that provide additional pathways. The FDA regulates human cells, tissues, and cellular and tissue based products. Dr. Deb Muth 21:05We call them HCT/PPS under two main pathways. Section 361 products are those that meet specific criteria. They’re minimally manipulated, intended for homologous use, meaning these tissues perform the same basic function in the recipient as it did in the donor. They’re not combined with non-tissue components and they’re either autotogus, meaning they come from your own tissue, or they have had minimal systemic effect. Dr. Deb Muth 21:38An example of a clear 361 procedure, your doctor harvests your own bone marrow, we call this PRP, performs minimally processing to or uh perform Yeah. performs minimal processing to concentrate the stem cells through a centriuge and injects it into your arthritic knee the same day. That’s autogus same day but minimally manipulated. Dr. Deb Muth 22:04This is unquestionably legal and is being done in regenerative medicine clinics across the country every single day. So there’s section 351 where products are those that don’t meet all the section 361 criteria. They’re classified as drugs or biologic products and they require FDA approval through clinical trials. Dr. Deb Muth 22:27Now here’s where this gets more nuanced. There are regenerative medicine clinics across the United States using stem cell and exoome therapies in different contexts. First FDA registered clinical trials. These are formal research studies with investigational new drug applications. Patients enroll in trials. They sign informed consents. Dr. Deb Muth 22:48They receive therapies as part of their structured research protocols. And this is completely legal and represents the gold standard for gathering evidence. Second is observational studies and registry programs. Many clinics are collecting systemic data on patient outcomes using these therapies even outside the FDA trials. Dr. Deb Muth 23:12They’re documenting results, tracking safety, and contributing to the growing body of clinical evidence. Third, there’s clinical practice under physician discretion. There are physicians using these therapies based on their own clinical judgment informed consent from patients and their interpretation of the regulatory framework particularly around minimal manipulation and homologous use. Dr. Deb Muth 23:34Now there are also state regulations that provide additional legal frameworks. So, for example, Florida has enacted the Right to Try Act and specific regenerative medicine legislation that allows physicians to offer certain stem cell therapies under the state oversight. Utah has passed similar legislation creating pathways for regenerative medicine products. Dr. Deb Muth 23:57And these state laws recognize that patients should have access to potentially beneficial therapies, particularly when used by trained physicians with appropriate informed consent. The regulatory question often centers around are these products minimally manipulated. Some products clearly are not. They’ve been cultured. Dr. Deb Muth 24:20They’ve been expanded in laboratories and those require FDA approval that they don’t have. The FDA has appropriately shut down clinics using those products. But there are other products that undergo processing that many physicians and manufacturers argue constitutes minimal manipulation. And these tissues are cleared, potentially fragmented or particulated to make them more suitable for injection, preserved using methods like cryopreservation or liophalization and packaged. Dr. Deb Muth 24:54But the cells are not cultured or expanded in the laboratory. The FDA has issued guidance suggesting that many of these processing steps constitute more than manipul minimal manipulation. But many physicians, particularly those who specialized in regenerative medicine for years, disagree with that interpretation and they believe that the processing qualifies as minimal manipulation and that the product should fall under section 361 when used for homologous purposes. Dr. Deb Muth 25:24Is there regulatory debate? Absolutely. The FDA and some clinicians have different interpretations of what constitutes minimal manipulation. But here’s the practical reality. There are hundreds of well-trained, bore certified physicians across the United States offering these therapies every single day. Dr. Deb Muth 25:42They’re doing so based on their understanding of the regulations, their clinical experience, their commitment to patient safety, and their belief that these therapies can help people who have exhausted conventional options. The FDA’s enforcement priorities have focused primarily on the most problematic cases. Clin clinics making blatant disease cure claims, products with documented safety issues, clear cases of cellular expansion and culture, or clinics operating with no medical oversight. Dr. Deb Muth 26:15Reputable regenerative medicine physicians are using products from companies that provide comprehensive documentation of their processing methods. third-party sterility testing, certificates of analysis showing bioactive content, and quality control measures that meet or exceed industry standards. Now, let me be very clear about something. Dr. Deb Muth 26:36Quality matters enormously. Not all stem cells and exoome products are created equal. Research by Burger and colleagues published in the Orthopedic Journal of Sports Medicine in 2021 analyzed 12 commercially available stem cell products and found that many contained zero viable cells, high levels of bacteria, endotoxins and inconsistent growth factor concentrations. Dr. Deb Muth 27:01This is why the company providing these biologic matters tremendously. You want products from manufacturers who provide transport documentation in sourcing and processing. Conduct third-party testing and sterility and potency. Offer certificates of analysis for each batch. Use standardized validated processing protocols. Dr. Deb Muth 27:24Have quality control measures that ensure consistency and don’t make outrageous cure claims or promise. The best regenerative medicine physician carefully vet their suppliers. They don’t use products from companies making unrealistic promises. They use products from manufacturers who are transparent, scientifically rigorous, and committed to quality. Dr. Deb Muth 27:46Now, you specifically ask about homologous use and collagen defects. So, let me address this directly for you. Under the FDA guidance, homologous use means the tissue performs the same basic function in the recipient as in the donor. So for connective tissue, tendons, ligaments, cartilage, fascia, all of that which are collagenrich structures using MSC’s or their derivatives could be considered homologous use. Dr. Deb Muth 28:17MSC’s in their native environment provide structural support to produce extracellular matrix including collagen. Using them to support healing in damaged collagen rich tissues like arthritic joints, torn tendons or degenerative ligaments is arguably the same basic function. So using exoomes derived from MSC’s to support collagen synthesis reduce inflammation and promote tissue healing in the same structures. Dr. Deb Muth 28:46Many practitioners argue this also qualifies as homologous use because you’re supporting the structure and function that MSC’s would naturally support. So here’s the bottom line on the regulatory reality. Regenerative medicine is available in the United States. It’s being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 29:11Some therapies are offered in FDA registered clinics and some are offered in observational studies. Some are offered in clinical practice under physician discretion, informed consent, and careful attention to safety. The regulatory landscape is evolving. There are ongoing discussions both federally and state levels about creating clearer pathways for these therapies. Dr. Deb Muth 29:32So, if you choose to go down this road, you want to work with physicians who understand the regulations, who use quality products from reputable manufacturers with rigorous testing and documentation, who are transparent about what they’re using and why, who discuss the current regulatory landscape honestly with you, and who prioritize your safety and truly informed consent above all else. Dr. Deb Muth 29:55This is not a lawless wild wild west. But it is also not as simple as everything is legal and unavailable. It’s a nuanced landscape that requires ethical knowledge. And these practitioners that have this knowledge have got to provide informed patients who understand both the potential benefits and the current regulatory context. Dr. Deb Muth 30:17So let’s have some fun here. Let’s talk about what really matters to you that are listening and that’s what conditions are being supported with these therapies. What does the research show and what are clinicians seeing in actual practice with patients? Because here’s what’s really important. We have both published research evidence and extensive clinical experience. Dr. Deb Muth 30:38And when the two align, that’s when we can feel confident and comfortable about using these approaches. So, let’s start where we have the most substantial evidence. joint health and muscularkeeletal conditions. For arthritis, we have good data. A systemic review by Tan and colleagues published in arthritis research and therapy in 2021 analyzed 20 randomized controlled trials in MSC therapy for knee osteoarthritis. Dr. Deb Muth 31:05They found significant improvements in pain and function particularly in mild to moderate disease. What’s really interesting is when researchers start analyzing whether it was the cells themselves or their secreted factors doing the work. They found that exoomeenriched preparations showed similar benefits to whole cell therapy. Dr. Deb Muth 31:26Now towen colleagues in the biioaterials paper from 2017 demonstrated that MSC derived exoomes could promote cartilage matrix synthesize and reduce inflammation markers. The exoomes carried microarnas that told cartilage cells to make more collagen and proteoglycans, the building blocks of healthy cartilage. Dr. Deb Muth 31:49In clinical practice, physicians are seeing patients with knee, hip, shoulder, and spinal arthritis, experiencing reduced pain, improved function, better motility, and in some cases, measurable improvements in their tissue. I want to share a story here with you because back in 2006, my husband was injured at work. Some of you might have heard me tell this story before. Dr. Deb Muth 32:11Um, he broke two discs in his back and underwent surgery very early on when we started using stem cells. They had put cages and plates in and they used MSC’s to put inside the cage to create a hardened bone so that he could have a fusion and hopefully not have any pain. At the time, what the physician didn’t realize or mistakenly did was he did not put any human bone mixed with these dead cadaavver bone MSC’s. Dr. Deb Muth 32:42And so the MSC’s never grew. They didn’t have anything to grow by. So the plates and the screws just kind of went back and forth for six months before he could see another physician that would look at him differently and understand what actually happened. That was very early on. Today we know so much more than we did before. Dr. Deb Muth 33:01Fast forward to 2014 when my husband was having problems and he couldn’t feel his legs, he couldn’t feel his feet. We decided to undergo uh exoo and stem cell therapy again and we saw a physician in Florida who harvested cells from his bone marrow and his blood and his fat and mixed that all together and then put that back into the back. Dr. Deb Muth 33:27and he had tremendous benefit from it. So, I tell this story because I want you to see the trajectory of how long this has been going on that we’ve been using this and we’re learning as we’re going and things are changing rapidly in this in this world. And so, what we know today and what I’m teaching you today may very well change in a month or six months or a year from now, but we have the foundation at least to understand what is helpful, what is not right now. Dr. Deb Muth 33:54But just be aware that if you’re embarking on exoome or stem cell therapy or MSC’s that you understand that this terrain is going to change. So back to my conversation about what other things can we treat? Well, we can treat tendon and ligament injuries, chronic tennis elbow, Achilles tendonopathy, rotator cuff tears, chronic planter fasciitis. Dr. Deb Muth 34:17These were researched by PA and colleagues in the American Journal of Sports Medicine in 2017 and it showed that bone marrow concentrate injections resulted in improved pain and function compared to steroid injections. Now this mechanism appears to be enhanced collagen remodeling and reduced chronic inflammation. Dr. Deb Muth 34:39These are structural collagenrich tissues using MSC’s or their derivatives for structural support which makes biological sense. It’s homologous use. It’s similar. So clinically we’re seeing athletes, active adults and people with chronic pain who failed physically um failed physical therapy, failed conservative treatments finding relief in this functional uh improvement in this functional world that we live in today. Dr. Deb Muth 35:07So, I want to be clear about what we’re doing here for joint and muscularkeeletal issues. We’re not growing completely new cartilage from scratch or severely destroyed joints. We’re not magically regenerating tissues that’s been gone for decades. That’s not possible here. What you’re doing when you’re using MSSE’s and exoomes is supporting the body’s natural ability to repair, reducing inflam inflammation and damage, and we’re driving progressive degeneration uh or we’re stopping the progressive degeneration. By reducing the Dr. Deb Muth 35:41inflammatory damage, we’re stimulating resonant stem cells that have been dormant. We’re improving blood flow and uh uh oxygen to the tissues like cartilage and tendons. and we’re organizing the body to start creating its own quality collagen as it heals. So, it’s a regenerative support, not a tissue replacement. Dr. Deb Muth 36:07But for many people, this support is lifechanging. So, let’s talk about autoimmune disorders now because this is one of the most exciting and unrecognized applications. autoimmune conditions like rheumatoid arthritis, lupus, MS, Crohn’s disease, ulcerative colitis, Hashimoto’s, they all involve the immune system and the immune system is deregulated. Dr. Deb Muth 36:30And so basically your immune system is seeing this tissue as foreign and it’s attacking it. These MSC’s and their exoomes have profound immune modulatory properties. They don’t suppress the immune system like steroids or imunosuppressive drugs. They modulate it helping to restore balance. So for rheumatoid arthritis, research by Weang and colleagues in stem cells translational medicine in 2016 showed that MSC derived exoomes could shift the balance of immune cells, reducing pro-inflammatory TH7 cells that drive joint disruption uh and increase Dr. Deb Muth 37:08regulatory TE-C cells that maintain immune tolerance. So for MS, a clinical trial by Kasus and colleagues published in archives of neurology back in 2010 evaluated autotogus MSC therapy and MS patients and they found evidence of reduced disease activity, improved neurological function and decreased inflammatory uh lesions on MRI scans. Dr. Deb Muth 37:34The proposed mechanism is MSC’s and their exoomes reduce inflammatory cytoine production promote regulatory imu immune populations support remination of damaged nerves that is rebuilding the protective coating around the nerve fibers and it reduces bloodb brain barrier permeability which prevents immune cells from attacking their brain and spinal cord. Dr. Deb Muth 38:02And so for inflammatory bowel disease, the research by Barnholm uh sorry Barnhorn and colleagues in gut in 2020 showed that MS cell MSC derived extracellular vesicles could support mucosal healing and reduce inflammation in the gut lining. They appeared to restore intestinal barrier function, healing that leaky gut and modulating local immune responses. Dr. Deb Muth 38:30So in clinical practice, physicians are seeing patients with autoimmune conditions, experiencing reduced disease flares, decreasing the need for imunosuppressive medications, improving energy and quality of life, and in some cases extending periods of remission. But here’s what I want you to understand. Dr. Deb Muth 38:52When you see these therapies for autoimmune conditions, we are supporting immune regulation and reducing inflammatory damage. We are not treating or curing the disease in a conventional sense. These therapies work best as part of a comprehensive functional medicine approach that also addresses gut health because 70% of your immune system lives in your gut and environmental triggers like mold, heavy metals, chemical toxins that can drive autoimmune responses, chronic infections that can trigger immune disregulation, stress and nervous system imbalance. And Dr. Deb Muth 39:29these nutritional deficiencies are necessary to help improve the immune function. So regenerative therapy without addressing root causes is like bailing water out of your boat without plugging the hole. You might get temporary relief, but the underlying problem still remains. So let’s talk about neurological conditions. Dr. Deb Muth 39:52And this is where the science gets truly fascinating. for traumatic brain injury and concussion. Research by Zang and colleagues in the Journal of Neurot Trauma in 2015 showed that MSC derived exoomes could reduce brain inflammation, promote neuroplasticity, that’s the brain’s ability to rewire itself and improve cognitive outcomes in animal models. Dr. Deb Muth 40:17The exoomes crossed the bloodb brain barrier, delivered neuroprotective proteins and microRNAs. They reduced inflammation, supported mitochondrial function in injured neurons and promoted both new blood vessels from new blood formation and neurogenesis and the birth of new neurons occurred. Neurological recovery requires a multi-systematic approach. Dr. Deb Muth 40:42Exoomes may support neural repair, but they work best combined with hormone optimization, growth hormone, testosterone, thyroid, pregnnolone, mitochondrial support compounds like NAD, CoQ10, PQQ, carnitine, all of those things that we use traditionally in functional medicine. Now for stroke recovery, there was research by Zinn and colleagues in the journal of extracellular vesicles that showed MSC derived exoomes reduced the size of brain damage and improved neurological recovery in animal models. There was a Dr. Deb Muth 41:19Parkinson’s disease study done by Kimoji and colleagues in the movement disorders in 2018 that suggested that MSSE derived exoomes could support dopamineergic neuron survival and those are the cells that die in Parkinson’s and it can help to reduce neuroinflammation. Clinically, physicians are seeing improvements in patients with postconussion syndrome, chronic traumatic brain injury, early stage cognitive decline, and other neurodeenerative conditions. Dr. Deb Muth 41:52These are not cures, but meaningful improvements in cognitive function, mood, energy, and quality of life. Now, let’s talk about autism spectrum disorder very carefully here because this is a very sensitive but very important topic for families. There have been several clinical trials that have explored MSC therapy for autism. Dr. Deb Muth 42:16Liv and colleagues published research in stem cell translational medicine in 2013 showing improvements in social interaction, communication, and behavioral symptoms in children with ASD who received cord blood MSC’s. Dawson and colleagues in 2017 conducted randomized trial autotogus cord blood infusion and found modest improvements in social communication particularly in children with higher baseline immune dysregulation. Dr. Deb Muth 42:47The proposed mechanisms for modulation of neuroinflammation support the mitochondrial function because many children with autism show evidence of mitochondrial dysfunction, reduction of oxidative stress, improvement in gut brain access dysfunction and modulation of immune dysregulation. In clinical practice, some physicians are seeing improvements in some children, better eye contact, increased language development, reduced sensory sensitivities, improved social engagement, but responses vary significantly, and we cannot predict which children will benefit most. So for Dr. Deb Muth 43:26families considering regenerative approaches for autism, these therapies are supporting the body’s healing mechanisms, reducing neuroinflammation, supporting cellular energy production, modulating immune function. These should only be considered as part of a comprehensive biomedical approach that includes dietary interventions to address food sensitivities, support gut health, environmental toxin removal, particularly heavy metals and chemical exposures, gut healing protocols with targeted probiotics and nutrients, Dr. Deb Muth 44:00metabolic testing and targeted supplementation, and evidence-based on behavioral and developmental therapies. These therapies should only be pursued with practitioners who are honest about what we know and what we don’t know and who follow rigorous safety protocols who never promise cures and who view regenerative medicine as a tool in the comprehensive healing strategy, not a standalone miracle. Dr. Deb Muth 44:26Not only that, these therapies will most likely need to be given several times over the course of this person’s lifetime, possibly even on an annual basis. And this is really important because it is not a oneandone. It is not a one-sizefits-all, and it needs to be looked at as a long-term option for working with autism. So, since we’re looking at stem cells versus exoomes, living cells, with stem cell therapy, you’re receiving living cells that can survive in your body for days to weeks. Dr. Deb Muth 45:02With exoome therapy, there are no living cells, just biological messages they would have sent. So, replication stem cells can potentially replicate. Although therapeutically this happens minimally, exoomes cannot replicate. They deliver the cargo and then they are cleared by your body. With stem cells, it’s primarily paracrine signaling. Dr. Deb Muth 45:28They’re coaching your cells to heal. With exoomes, it’s pure signaling, pure reprogramming your cells without any cellular component. Stem cells as we talked about can be autotogus from your own bone fat, blood or um bone marrow or allergenic from umbilical cord tissue or Wharton’s jelly. Dr. Deb Muth 45:50Exoomes are typically derived from cultured MSC’s often from umbilical cord or bone marrow sources and both can be given by local injection for targeted treatment of joints and tissues and exoomes can be given intravenously for whole body systemic support. both have um low immun immunogicity. I can’t say that word today. Dr. Deb Muth 46:17But exoomes have even lower risk since they contain no cellular material. Now, it’s absolutely critical for you to understand that there are massive quality differences. We’ve talked about this earlier. I want you to be very aware of this and have a conversation with any of the practitioners that you’re considering undergoing this treatment with. Dr. Deb Muth 46:37Here is where it matters more than anything when you’re considering regenerative medicine, the quality of the products and the expertise of the practitioner. Because the reality is not all regenerative medicine products are created equal. We all know that when we take different supplements and not all practitioners understand these therapies at the same depth. Dr. Deb Muth 46:58You want to look for practitioners that are board certified or have some kind of specialized regenerative medicine training. You want to know their clinical experience. How much have they done these procedures? How long have they done this? You want honest communication about the evidence and the limitations in this. Dr. Deb Muth 47:17You want a comprehensive functional medicine approach to go along with these therapies. And you want somebody that’s transparent about their informed consent and their regulatory status. If you have people that are uh claiming that they can cure disease or giving you guarantees, that is not that is not a good practitioner to work with. Dr. Deb Muth 47:37If you have high pressure sales tactics, you need to decide today limited supply for a week. These are marketing manipulations. It’s not medical care. You want to be cautious of extremely low prices because quality regenerative products are expensive to source, process, and test. and store. And if somebody’s offering stem cells or exoomes for a few hundred dollars, seriously, you need to question the quality, the safety, and where they got this from. Dr. Deb Muth 48:09So before undergoing any regenerative therapy, make sure you’re having a very, very lengthy conversation with the person and so you truly understand exactly what you’re getting, how it’s going to be delivered, and what they’re going to do. If there’s one thing I want you to take away from today is that your body has remarkable capacity to heal when given the right biological signals and the right environment. Dr. Deb Muth 48:35Stem cells and exoomes are powerful tools for providing biological signaling that can reduce inflammation, modulate immune function, support tissue repair, and restore cellular communication that’s been disrupted by chronic disease and inflammation. These therapies are available in the United States through trained physicians working in FDA registered trials, observational studies, and clinical practice, and using quality products from manufacturers with rigorous testing and quality control. Dr. Deb Muth 49:04So before you invest in regenerative medicine, do your homework. Ask detailed questions about product quality and source. Verify the products come from reputable manufacturers with certificates of analysis, third-party testing. Work with experienced practitioners. And remember, no injection, no infusion, no biologic can overcome ongoing toxic exposure, chronic stress, poor nutrition, gut dysfunction, and inadequate sleep. Dr. Deb Muth 49:34True healing requires your body and you to actively participate in this healing. If you are unwilling to address the root causes and change the lifestyle factors that disrupted your health in the first place, the biologics can amplify your healing signals, but you have to create the internal environment where healing can actually happen. Dr. Deb Muth 49:56So, I hope this episode has helped you understand regenerative medicine more clearly. Share it with somebody who’s looking for healing beyond the conventional approaches. And until next time, this has been Let’s Talk Wellness Now. Have a blessed day. >> Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Dr. Deb Muth 50:16Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided forformational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. Dr. Deb Muth 50:41While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Your use of information from this broadcast is entirely at your own risk. Dr. Deb Muth 51:00By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time, and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 265 – The Future of Healing: How Exosomes Re-Educate Your Body to Heal Itself first appeared on Let's Talk Wellness Now.