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AI is transforming medicine at a speed never seen before. In this episode, you'll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he's a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension. Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today's standards. You'll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life. You'll Learn: • How digital twins will end human drug testing • Why AGI could replace doctors and computer jobs within five years • How AI models immune function, metabolism, and aging • The role of mitochondria and inflammation in longevity • How GLP-1 drugs and metformin extend lifespan • What continuous biological monitoring means for health tracking • How AI is transforming functional medicine and personalized care • Why NAD and energy metabolism are key to human performance They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You'll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan. This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation. This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You'll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, Metabolism, AGI, Clinical trials, Human performance, Aging research, Systems biology, Immunology, Smarter Not Harder Thank you to our sponsors! BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order Resources: • Keep up with Derya's work: https://x.com/derya_?lang=en • Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 — Trailer 01:25 — Intro 02:26 — AI's Role in Extending Lifespan 02:56 — Regulatory Frameworks and Medical Adoption 05:19 — Problems with the Immune System 08:19 — Chronic Fatigue and Long COVID Research 10:32 — Modern Testing and Multi-Omic Analysis 14:07 — Personal Longevity Strategy and Supplements 15:17 — Understanding Exhausted Cells 23:43 — Personalization in Medicine and AI Analysis 31:35 — Longevity Escape Velocity 36:13 — AI Doctors and Prescriptions 39:55 — Data Quality Concerns in AI Training 43:19 — The Future of Wearable Technology 45:50 — Revolutionizing Education with AI 49:04 — The Future of Higher Education 52:03 — Future of Work and AI Agents See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The Nobel Prize in physiology or medicine was awarded to three scientists for their work in immunology. Daniel Griffin, MD, PhD, Chief of Infectious Disease for Island Infectious Diseases, the largest physician-owned Infectious Disease Specialist Group on Long Island, an infectious disease specialist and clinical instructor of medicine at Columbia University and president of Parasites Without Borders and co-host of the podcast "This Week in Virology", explains their breakthrough and what it means for future treatments for autoimmune diseases, cancer, and more.
Elizabeth Marnik, also known as Science Whiz Liz, grew up unvaccinated, yet she is now an immunologist, science communicator, and advocate for vaccines–this is her story. Host: Cindy Leifer Guest: Elizabeth Marnick Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server More about Liz on her webpage ScienceWhizLiz on Instagram From the Science Classroom with Science Whiz Liz on Substack Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
mRNA vaccines are not supposed to contain DNA. But Dr. Jessica Rose says a new study tested “32 vials of Pfizer and Moderna COVID products that included 16 unique lots… We did not only find DNA, we found it in ALL lots tested and most importantly, the DNA levels were all above pre-designated EMA thresholds of 10 ng/dose.” “We measured the amount of DNA in the vials using 2 methods… (qPCR and fluorometry),” she continues. “It was submitted as evidence on the congressional record by the honorable Senator Ron Johnson.” JP Sears is a comedian, author, and YouTuber known for his satirical take on politics, fitness, and faith. He hosts Awaken with JP on Rumble and YouTube. Follow at https://x.com/AwakenWithJP Dr. Jessica Rose is a Canadian researcher with a Bachelor's in Applied Mathematics and a Master's in Immunology from Memorial University of Newfoundland. She holds a PhD in Computational Biology from Bar Ilan University and completed postdoctoral research in Molecular Biology and Biochemistry. Find her at https://jessicasuniverse.com and follow at https://x.com/JesslovesMJK 「 SUPPORT OUR SPONSORS 」 Find out more about the brands that make this show possible and get special discounts on Dr. Drew's favorite products at https://drdrew.com/sponsors • FATTY15 – The future of essential fatty acids is here! Strengthen your cells against age-related breakdown with Fatty15. Get 15% off a 90-day Starter Kit Subscription at https://drdrew.com/fatty15 • PALEOVALLEY - "Paleovalley has a wide variety of extraordinary products that are both healthful and delicious,” says Dr. Drew. "I am a huge fan of this brand and know you'll love it too!” Get 15% off your first order at https://drdrew.com/paleovalley • VSHREDMD – Formulated by Dr. Drew: The Science of Cellular Health + World-Class Training Programs, Premium Content, and 1-1 Training with Certified V Shred Coaches! More at https://drdrew.com/vshredmd • THE WELLNESS COMPANY - Counteract harmful spike proteins with TWC's Signature Series Spike Support Formula containing nattokinase and selenium. Learn more about TWC's supplements at https://twc.health/drew 「 MEDICAL NOTE 」 Portions of this program may examine countervailing views on important medical issues. Always consult your physician before making any decisions about your health. 「 ABOUT THE SHOW 」 Ask Dr. Drew is produced by Kaleb Nation (https://kalebnation.com) and Susan Pinsky (https://twitter.com/firstladyoflove). This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. Learn more about your ad choices. Visit megaphone.fm/adchoices
Immune discusses the potential future of delivering vaccines by flossing your teeth and how antibodies in human milk shape the normal immune responses in newborns. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Floss-based vaccination (Nat Biomed Engineering 2025) Press article on Floss-based vaccine paper (Sci News) Human milk IgA promotes immune development (PNAS 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
Jessica Sheldon (PhD) is on a mission to starve out Acinetobacter baumannii —one of the world's most virulent hospital-borne pathogens. Notorious for its speedy evolution and multi-drug resistance, the hospital-borne bacteria lingers on dry surfaces and infects critically-ill patients, leading to sepsis, pneumonia and high mortality rates. In this episode, Sheldon delves into the real-life events that drove her to investigate histamine, and its role in bacterial survival and immune response. In 2022, Sheldon joined the University of Saskatchewan's College of Medicine as an assistant professor of Biochemistry, Microbiology & Immunology -- something she now laughs about after an ill-fated high school placement in an immunology laboratory. “Cytokine cascades, pathways, the signaling just got way over my head real fast,” said Sheldon. “I didn't really know what I was doing.” Sheldon enrolled at Lakehead University, drawn to the tiny pathogens with outsized roles in movies like Outbreak. She estimates she read the book The Hot Zone 20 times. Her persistence paid off. “One of my second year microbiology teachers said, ‘you know, I think you're kind of good at this. Maybe you should try it as a career.' Sheldon zeroed in on metals and wrote her doctoral dissertation on the role iron plays in the proliferation of bacteria such as Methicillin-resistant staphylococcus aureus (MRSA). Today, she studies both Morganella morganii and Acinetobacter baumannii — the multi-drug-resistant bacteria singled out twice in the last decade by the World Health Organization as a ‘priority 1-critical pathogen'. “I'm perpetually fascinated by the idea that something so small can change the course of history,” said Sheldon. “And we've seen that recently with COVID.” Sheldon was already studying the metal uptake and signalling systems that grow and sustain A. baumannii when the bacteria ripped through hospitals during the pandemic, attacking Covid-infected patients on ventilators. By 2023, Sheldon landed a five-year CIHR grant of $900,000 to study A. Baumannii and the way it turns histidine into histamine. Her goal is to pinpoint the way the pathogen uses histamine to evade its host, as it sends out siderophores to steal iron and other nutrients. The compound appears to serve as a signalling mechanism for both the host and the invading pathogen, she said. “We know the bacteria are using histamine in the synthesis of these molecules to get iron, but they're also secreting it into the environment. We're not really sure why,” Sheldon said. Her laboratory is working to trace and target those pathways, so researchers can identify and potentially develop new treatments — small molecules or antibody inhibitors that could disrupt multi-drug resistant pathogens. Beyond A. baumannii, histamine may hold the key to how some of the world's most notorious bacteria grow, spread, and evade immune defences, Sheldon said. “We're running out of drugs, but there's really not a full appreciation for the fact that we're losing the ability to treat bacterial infections,” Sheldon said. “We need to develop supplementary therapies or alternative therapies.”
How do you hold on to hope while still being realistic about the work that needs to be done? Immunology researcher David Fajgenbaum and public health expert Celina de Sola discuss how they scaled personal missions into organizations making long-term impact on communities near and far. They explore how to stay motivated, discover your leadership style and uncover overlooked solutions hiding in plain sight. (This conversation is part of "TED Intersections," a series featuring thought-provoking conversations between experts navigating the ideas shaping our world.)Interested in learning more about upcoming TED events? Follow these links:TEDNext: ted.com/futureyouTEDAI Vienna: ted.com/ai-viennaTEDAI San Francisco: ted.com/ai-sf Hosted on Acast. See acast.com/privacy for more information.
REFERENCES Autoimmun. 2012 Mar 28;38(4):344–353The Journal of Immunology, 2009. Volume 182, Issue Supplement_1, AprIL. Page 99.1, Trends in Immunology 2025. ReviewVolume 46, Issue 4p324-337AprilCytokine. 2024 Feb 15;176:156540. Proc Natl Acad Sci U S A. 2013 Jun 10;110(26):10652–10657J Cell Sci. 2019 Sep 16;132(18):jcs213124.Cellular & Molecular Immunology 2025. volume 22, pages134–149 Plant/Page.1971. Battle of Evermore on LZIV.https://music.youtube.com/watch?v=88b0OYxdtyM&si=axHZuES3K2lftqDTWinwood, S.1969. Had to Cry Today. Blind Faith.https://music.youtube.com/watch?v=Z4Yo_VbGdMg&si=Pq0OXwT0lW2pUmT8Mozart, WA. 1781. Idomeneo Overture K 366.https://music.youtube.com/watch?v=OAXn_rs17m4&si=nFI7jghahXFS7NhT
Immunology and inflammation are hot topics in biotech and biopharma, and innovations are emerging that can change the game for patients suffering from autoimmune, gastrointestinal, and metabolic disease. For top pharma companies, identifying these innovations early is essential and, for university labs, spinouts and startups, getting their science in front of the right industry partners is key. So how does science meet industry, and how can top pharma and venture investors find the next blockbuster?This week I sat down with Joseph Ferner of Inpart, the author of a new R&D Trends Report on Immunology and Inflammation. He explained the shape of the research landscape, the areas that are generating the most interest amongst industry and investors, and the ways in which digital platforms are helping innovative scientists connect with those who have the experience and finance to bring their technologies and therapies to market.Download the Immunology & Inflammation R&D Trends ReportCreate a free Inpart Connect accountSpeak with the Inpart team02:18 The 2025 Immunology and Inflammation R&D Trends Report08:30 Priorities and challenges in immunology and inflammation research10:18 The impact of immune system complexity on drug development13:12 The challenge of clinical heterogeneity15:33 The role of organoids in immunology and inflammation R&D17:10 Comparing organoid models to animal models19:51 The R&D landscape in 202522:40 Popular modalities in immunology and inflammation research24:45 The top innovations in the 2025 R&D Trends Report28:56 How to score and rank innovations in a rapidly evolving market33:22 Engagement trends between researchers and industry partners37:09 Why companies decline to engage with academic researchers43:36 The Inpart Connect platform and how it works48:49 Looking forward to the next R&D Trends ReportInterested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletterTo dive deeper into the topic: Why is the immunology and inflammation market suddenly attracting a wave of investment?
Is that penicillin or amoxicillin allergy real? Probably not. In this episode, we explore how to assess risk, talk to parents, and refer for delabeling. You'll also learn what happens in the allergy clinic, why the label matters, and how to be a better antimicrobial steward. Learning Objectives Describe the mechanisms and clinical manifestations of immediate and delayed hypersensitivity reactions to penicillin, including diagnostic criteria and risk stratification tools such as the PEN-FAST score. Differentiate between low-, moderate-, and high-risk penicillin allergy histories in pediatric patients and identify appropriate candidates for direct oral challenge or allergy referral based on current evidence and guidelines. Formulate an evidence-based approach for evaluating and counseling families in the Emergency Department about reported penicillin allergies, including when to recommend outpatient referral for formal delabeling. Connect with Brad Sobolewski PEMBlog: PEMBlog.com Blue Sky: @bradsobo X (Twitter): @PEMTweets Instagram: Brad Sobolewski References Khan DA, Banerji A, Blumenthal KG, et al. Drug Allergy: A 2022 Practice Parameter Update. J Allergy Clin Immunol. 2022;150(6):1333-1393. doi:10.1016/j.jaci.2022.08.028 Moral L, Toral T, Muñoz C, et al. Direct Oral Challenge for Immediate and Non-Immediate Beta-Lactam Allergy in Children. Pediatr Allergy Immunol. 2024;35(3):e14096. doi:10.1111/pai.14096 Castells M, Khan DA, Phillips EJ. Penicillin Allergy. N Engl J Med. 2019;381(24):2338-2351. doi:10.1056/NEJMra1807761 Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review.JAMA. 2019;321(2):188–199. doi:10.1001/jama.2018.19283 Transcript Note: This transcript was partially completed with the use of the Descript AI and the Chat GPT 5 AI Welcome to PEM Currents, the Pediatric Emergency Medicine podcast. As always, I'm your host, Brad Sobolewski, and today we are taking on a label that's misleading, persistent. Far too common penicillin allergy, it's often based on incomplete or inaccurate information, and it may end up limiting safe and effective treatment, especially for the kids that we see in the emergency department. I think you've all seen a patient where you're like. I don't think this kid's really allergic to amoxicillin, but what do you do about it? In this episode, we're gonna break down the evidence, walk through what actually happens during de labeling and dedicated allergy clinics. Highlight some validated tools like the pen FAST score, which I'd never heard of before. Preparing for this episode and discuss the current and future role of ED based penicillin allergy testing. Okay, so about 10% of patients carry a penicillin allergy label, but more than 90% are not truly allergic. And this label can be really problematic in kids. It limits first line treatment choices like amoxicillin, otitis media, or penicillin for strep throat, and instead. Kids get prescribed second line agents that are less effective, broader spectrum, maybe more toxic or poorly tolerated and associated with a higher risk of antimicrobial resistance. So it's not just an EMR checkbox, it's a label with some real clinical consequences. And it's one, we have a role in removing. And so let's understand what allergy really means. And most patients with a reported penicillin allergy, especially kids, aren't true allergies in the immunologic sense. Common misinterpretations include a delayed rash, a maculopapular, or viral exum, or benign, delayed hypersensitivity, side effects, nausea, vomiting, and diarrhea. And unverified childhood reactions that are undocumented and nonspecific. Most of these are not true allergies. Only a very small subset of patients actually have IgE mediated hypersensitivity, such as urticaria, angioedema, wheezing, and anaphylaxis. These are super rare, and even then they may resolve over time without treatment. If a parent or sibling has a history of a penicillin allergy, remember that patient might actually not be allergic, and that is certainly not a reason to label a child as allergic just because one of their first degree relatives has an allergy. So right now, in 2025, as I'm recording this episode, there are clinics like the Pats Clinic or the Penicillin Allergy Testing Services at Cincinnati Children's and in a lot of our peer institutions that are at the forefront of modern de labeling. Their approach reflects the standard of care as outlined by the. Quad ai or the American Academy of Allergy, asthma and Immunology and supported by large trials like Palace. And you know, you have a great trial if you have a great acronym. So here's what happens step by step. So first you stratify the risk. How likely is this to be a true allergy? And that's where a tool like the pen fast comes. And so pen fast scores, a decision rule developed to help assess the likelihood of a true penicillin allergy based on the patient's history. The pen in pen fast is whether or not the patient has a self-reported history of penicillin allergy. They get two points if the reaction occurred in the past five years. Two points if the reaction is anaphylaxis or angioedema. One point if the reaction required treatment, and one point if the reaction was not due to testing. And so you can get a total score of. Up to six points. If you have a score of less than three. This is a low risk patient and they can be eligible for direct oral challenge. A score greater than three means they're higher risk and they may require skin testing. First validation studies show that the PEN FFA score of less than three had a negative predictive value of 96.3%. Meaning a very, very low chance of a true allergy. And this tool has been studied more extensively in adults, but pediatric specific adaptations are emerging, and they do inform current allergy clinic protocols. But I would not use this score in the emergency department just to give a kid a dose of amoxicillin. So. For low risk patients, a pen fast score of less than three or equivalent clinical judgment clinics proceed with direct oral challenge with no skin testing required. The protocol is they administer one dose of oral amoxicillin and they observe for 62 120 minutes monitoring for signs of reaction Urticaria. Respiratory symptoms or GI upset. This approach is safe and effective. There was a trial called Palace back in 2022, which validated this in over 300 children. In adolescents. There were no serious events that occurred. De labeling was successful in greater than 95% of patients. And skin tested added no benefit in low risk patients. So if the child tolerates this dose, then you can remove that allergy immediately from the chart. Parents and primary care doctors will receive a summary letter noting that the challenge was successful and that there's new guidance. Children and families are told they can safely receive all penicillins going forward. And providers are encouraged to document this clearly in the allergy section of the EMR. So you're wondering, can we actually do this in the emergency department? Technically, yes, you can do what you want, but practically we're not quite there yet. So we'd need clearer risk stratification tools like the Pen fast, a safe place for monitoring, post challenge, clinical pathways and documentation support. You know, a clear way to update EMR allergy labels across the board and involvement or allergy or infectious disease oversight. But it's pretty enticing, right? See a kid you diagnose otitis media. You think that their penicillin allergy is wrong, you just give 'em a dose of amox and watch 'em for an hour. That seems like a pretty cool thing that we might be able to do. So some centers, especially in Canada and Australia, do have some protocols for ED or inpatient based de labeling, but they rely on that structured implementation. So until then, our role in the pediatric emergency department is to identify low risk patients, avoid over document. Unconfirmed reactions and refer to allergy ideally to a clinic like the pets. So who should be referred and good candidates Include a child with a rash only, especially one that's remote over a year ago. Isolated GI symptoms. Parents unsure of the details at all. No history of anaphylaxis wheezing her hives, and no recent serious cutaneous reactions. I would avoid referring and presume that this allergy is true. If they've had recent anaphylaxis, they've had something like Stevens Johnson syndrome dress, or toxic epidermolysis necrosis. Fortunately, those are very, very rare with penicillins and there's a need for penicillin during the ED visit without allergy backup. So even though we don't have an ED based protocol yet. De labeling amoxicillin or penicillin allergy can start with good questions in the emergency department. So here's one way to talk to patients and families. You can say, thanks for letting me know about the amoxicillin allergy. Can I ask you a few questions to better understand what happened? This is gonna help us decide the safest and most effective treatment for your child today, and then possibly go through a process to remove a label for this allergy that might not be accurate. You wanna ask good, open-ended questions. What exactly happened when your child took penicillin or amoxicillin? You know, look for rash, hives, swelling, trouble breathing, or anaphylaxis. Many families just say, allergic, when the reaction was just GI upset, diarrhea or vomiting, which is not an allergy. How old was your child when this happened? Reactions that occurred before age of three are more likely to be falsely attributed. How soon after taking the medicine did the reaction start? Less than one hour is an immediate reaction, but one hour to days later is delayed. Usually mild and probably not a true allergy. Did they have a fever, cold or virus at that time? Viral rashes are often misattributed to antibiotics, and we shouldn't be treating viruses with antibiotics anyway, so get good at looking at ears and know what you're seeing. And have they taken similar antibiotics since then? Like. Different penicillins, Augmentin, or cephalexin. So if they said that they were allergic to amoxicillin, but then somehow tolerated Augmentin. They're not allergic. If a patient had rash only, but no hive swelling or difficulty breathing, no reaction within the first hour. It occurred more than five years ago or before the kid was three. And especially if they tolerated beta-lactam antibiotics. Since then, they're a great candidate for de labeling and I would refer that kid to the allergy clinic. Generally, they can get them in pretty darn quick. Alright, we're gonna wrap up this episode. Most kids labeled penicillin allergic or amoxicillin allergic, or not actually allergic to the medication. There are some scores like pen fasts that are validated tools to assess risk and support de labeling. Direct oral challenge for most patients is safe, efficient, and increasingly the standard of care. There are allergy clinics like the Pats at Cincinnati Children's that can dela children in a single visit with oral challenges alone, needing no skin testing, and emergency departments can play a key role in identifying and referring these patients and possibly de labeling ourselves in the future. Well, that's all for this episode on Penicillin Allergy. I hope you learn something new, especially how to assess whether an allergy label is real, how to ask the right questions and when to refer to an allergy testing clinic. If you have feedback, send it my way. Email, comment on the blog, a message on social media. I always appreciate hearing from you all, and if you like this episode, please leave a review on your favorite podcast app. Really helps more people find the show and that's great 'cause I like to teach people stuff. Thanks for listening for PEM Currents, the Pediatric Emergency Medicine podcast. This has been Brad Sobolewski. See you next time.
Dr. Hafeez Diwan: The Power of 'Meh', Writing Passions, and Handling Obnoxious PeopleIn this episode of The Girl Doc Survival Guide, Dr. Hafeez Diwan, Professor of Pathology, Immunology, and Dermatology at Baylor College of Medicine, shares insights on his diverse writing endeavors, from self-help books to a young adult sci-fi fantasy novel co-authored with his daughter. Highlighting ideas from his books 'The Power of Meh' and 'How to Love Obnoxious People,' Dr. Diwan discusses strategies for managing emotions, overcoming willpower challenges, and promoting mindfulness. He also reflects on his medical journey and the interplay between his writing and his medical practice.00:00 Introduction to Dr. Hafeez Diwan00:58 Anecdote from Residency02:50 The Writing Journey Begins05:18 The Power of Meh07:26 Loving Obnoxious People11:12 Mastering Willpower14:40 Final Thoughts and Advice
ReferencesCell Mol Life Sci. 2022 Jul 12;79(8):419.J Autoimmun. 2012 Mar 28;38(4):344–353Trends in Immunology.2017. REVIEW| v. 38,I4, P287-297, Saint-Saens, C. 1886. Symphony 3 in C Minor Op.78https://music.youtube.com/watch?v=ZWCZq33BrOo&si=A7uooZ7N9HCELVTK
The Evidence Based Chiropractor- Chiropractic Marketing and Research
In today's episode, we're diving into some brand new, cutting-edge research that turns the spotlight on microglia—the tiny, yet mighty immune cells in your spinal cord. Dr. Jeff explores a recent review published in Frontiers in Immunology that unpacks how microglia play a pivotal role in neuroinflammation, plasticity, and recovery after spinal cord injury.Episode Notes: Evolving insights on the role of microglia in neuroinflammation, plasticity, and regeneration of the injured spinal cordLeander Tables- Save $1,000 on the Series 950 Table using the code EBC2025 — their most advanced flexion-distraction tablePatient Pilot by The Smart Chiropractor is the fastest, easiest to generate weekly patient reactivations on autopilot…without spending any money on advertising. Click here to schedule a call with our team.Our members use research to GROW their practice. Are you interested in increasing your referrals? Discover the best chiropractic marketing you aren't currently using right here!
In this episode of the Ageless Future podcast, Regan Archibald sits down with Dr. Natalia Mitin, a leading researcher in immunology and longevity, to discuss how aging is fundamentally driven by the immune system. Dr. Mitin breaks down complex mechanisms like immunosenescence and T-cell exhaustion and introduces her company's breakthrough SapereX test, which measures immune system age with high precision. They explore why traditional longevity biomarkers like telomeres often miss the mark, and how direct T-cell gene expression provides clinicians with actionable insights. This episode also covers key interventions—from stem cell support to senolytics—and emphasizes the importance of tailoring protocols based on actual biological needs rather than trends. Dr. Mitin and Regan underscore a powerful message: true longevity starts with personalized diagnostics and measured interventions, not guesswork. www.saperex.comhttps://www.linkedin.com/in/nataliamitin/
Cindy speaks with Aimee Pugh Bernard from University of Colorado about her career and her passion for teaching and communicating immunology to the public. Host: Cindy Leifer Guest: Aimee Pugh Bernard Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server More about Aimee on her webpage Funsizeimmuninja on Instagram Fun Size Science video partnership with Unbiased Science Funsizeimmuninja Substack Society for Leukocyte Biology Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
Minuscule pieces of waste plastic, thousands of times smaller than a human hair, can damage our brains and may be contributing to the increasing global levels of Alzheimer's and Parkinson's disease. That's according to new research led by Dr Gavin Davey, From the School of Biochemistry and Immunology, Trinity College Dublin who spoke to Newstalk Breakfast.
In this episode, we review the high-yield topic of Common Variable Immunodeficiency Disorder (CVID) from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Antigen Processing and Presentation from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Autumn is here, and so are our friends, the dust mites! But what are they, where do they live, and what can we do to avoid them? Christine Loscher, Professor of Immunology at DCU, has the answers!
In this episode, we review the high-yield topic of Primary Lymphoid Tissue from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of IL-12 Receptor Deficiency from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Indolent Systemic Mastocytosis (ISM) is a rare but often underrecognized clonal mast cell disorder. From random hives to gut pain and brain fog, ISM can feel like a medical mystery. We continue our review of “Management of indolent mastocytosis and mast cell activation syndrome - A clinical yardstick,” published in June 2025 in The Annals of Allergy, Asthma & Immunology. This is Part 2 of our discussion, with a focus on indolent systemic mastocytosis. We look at what causes it, how it's diagnosed, and how to manage symptoms and improve quality of life. In this episode, we break down this complex mast cell disease and how doctors use baseline serum tryptase, KIT D816V testing, and HaT screening to find answers. Plus, we explain how treatments like antihistamines, mast cell stabilizers, and avapritinib can help people live better with ISM.
AI- generated beer and the first AI- enabled drug reaches a clinical milestone. Professor of Biochemistry at the school of Immunology, Trinity College Luke O'Neill has all the latest science next.
In this episode, we review the high-yield topic of Hyper IgE Syndrome / Job Syndrome from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Cancer Revolution, a new exhibition in Stephen's Green Shopping Centre, explores the history and origins of cancer.It covers everything from fossil records of cancer in dinosaurs to today's cutting-edge breakthroughs in immunotherapy and genetics.The research done to discover this kind of science is helping to pioneer future medicine.Luke O'Neill, Professor of Biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin and one of Cancer Revolution's ambassadors joins Andrea to walk through the exhibition!Image: Breakthrough Cancer Research
What if hair loss was really a signal from your body, not just a cosmetic issue?In this episode, I talk with VJ Hamilton, The Autoimmune Nutritionist, about overcoming alopecia areata and other forms of hair loss by addressing root causes. We dive into nutrient deficiencies, gut health, thyroid imbalances, and inflammation and how functional medicine can help hair grow back naturally.If you've been told there's no hope for hair loss, this episode will challenge that belief.Episode Timeline: 00:00 – Episode Preview02:07 – Podcast Intro02:32 – Meet VJ Hamilton, Autoimmune Nutritionist04:02 – VJ's Story: Alopecia at Age 705:24 – Reversing Fatigue, Psoriasis, and Chronic Issues08:55 – Hair Loss: Autoimmune vs. Other Causes12:58 – Hair Regrowth: Healing Timeline16:09 – Inflammation Triggers: Gut, Scalp, Whole Body18:12 – Five Key Hair Loss Markers25:44 – Biotin: Overrated or Essential?27:50 – Nutrients: Selenium, Vitamin A, Genetics31:29 – Low Stomach Acid and Absorption33:01 – Supplements vs. Food for Hair Growth35:05 – First Steps with Hair Loss Diagnosis36:07 – Complex Cases: Mold, Toxins, Nervous System39:25 – Connect with VJ Hamilton Online40:42 – Podcast Outro41:03 – Root Cause Healing: Final TakeawaysAbout VJ Hamilton:VJ Hamilton, also known as The Autoimmunity Nutritionist, is the founder of The Autoimmune Nutrition Clinic and a Registered Nutritionist specialising in reversing hair loss, particularly alopecia areata, and other autoimmune-related conditions. With a Medical Science degree (BSc) in Biochemistry & Immunology and certification from the Institute for Functional Medicine, VJ combines scientific expertise with lived experience to deliver evidence-based, personalised therapies. Connect with VJ Hamilton:VJ Hamilton's Website: https://theautoimmunitynutritionist.com VJ Hamilton's FB Page: https://www.facebook.com/A.Nutritionist/ To take the Save My Thyroid Quiz visit www.savemythyroid.com/quiz Free resources for your thyroid health Get your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.com High-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto' sHave you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto's, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com. Do You Want Help Saving Your Thyroid? Click Here to access hundreds of free articles and blog posts. Click Here for Dr. Eric's YouTube channel Click Here to join Dr. Eric's Graves' disease and Hashimoto's group Click Here to take the Thyroid Saving Score Quiz Click Here to get all of Dr. Eric's published booksC...
In this episode, we review the high-yield topic of T-Cell Activation from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Mikki Tal, PhD, is a Principal Scientist at MIT's Department of Biological Engineering and Associate Scientific Director of the MIT Center for Gynepathology Research. She leads the Tal Research Group, focusing on host-pathogen interactions, immune responses to infections like Lyme disease, and the mechanisms behind chronic illnesses, particularly their disproportionate impact on women. She earned her PhD in Immunobiology from Yale University and conducted postdoctoral research at Stanford University's Institute for Stem Cell Biology and Regenerative Medicine. Tal was the recipient of our 2018 Bay Area Lyme Foundation Emerging Leader Award.
Listen as pulmonologist Peter Dicpinigaitis discusses his approach to the diagnosis and management of patients with refractory chronic cough in the context of a clinically relevant case and provides insights regarding emerging therapies.PresenterPeter Dicpinigaitis, MDProfessor of MedicineAlbert Einstein College of MedicineDivision of Critical Care MedicineMontefiore Medical CenterDirector, Montefiore Cough CenterBronx, New YorkLink to full program:https://bit.ly/4kweynG
Dr. Eric Vivier is a Professor of Immunology at Aix-Marseille Université and the Centre d'Immunologie de Marseille-Luminy. He is also an awardee of the European Research Council and a member of the French Society of Immunology. In this special episode recorded at the IUIS 2025 Congress in Vienna, Dr. Vivier highlights the critical importance of investing in science, explores the responsibility of governments and other organizations in funding research, and reflects on the role science plays in society.
In this episode, we review the high-yield topic of Immunization from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
First, the La Jolla Institute for Immunology is studying ghost viruses, which are passed down by our ancestors. Then, clean energy projects are getting a boost in funding and new election mailers are headed to your mailbox. Next, how the Carlsbad Theater owners are trying to save its legacy. Finally, we take a look at La Ópera de Tijuana which celebrates their 25 year anniversary.
Send us a textCellular clean up by immune cells and how early-life fructose exposure leads to neurodevelopmental problems.Episode Summary: Dr. Justin Perry talks about the body's constant cellular turnover—about 3 million cells die per second in adults (double in children and women)—handled by phagocytes like macrophages that engulf and digest debris to prevent diseases like lupus. They explore phagocytosis steps, macrophage adaptations in tissues like the brain (microglia), and how high fructose intake impairs microglial function in developing mice, leading to uncleared brain cells and anxiety-like behaviors, with implications for human neurodevelopmental disorders amid rising fructose consumption.About the guest: Justin Perry, PhD is an immunologist and clinical psychologist who leads a lab at Memorial Sloan Kettering Cancer Center focusing on how the body clears dead cells and debris to maintain homeostasis.Discussion Points:The body turns over 1-2% of its 30 trillion cells daily, mostly blood cells, but neurons in kids and endometrium in women turnover at ~2x this ratePhagocytosis involves "find me," "eat me," and digestion signals; failures can cause autoimmunity.Microglia are brain macrophages that uptake fructose via GLUT5 transporter.Early high fructose exposure (comparable to one soda daily) impairs the pruning of synapses and dead neurons.In mice, prenatal or postnatal fructose causes phagocytosis deficits in the prefrontal cortex, leading to heightened fear responses and poor fear extinction, mimicking anxiety disorders.Fructose correlates with rising neurodevelopmental issues like autism and anxiety; it's passed via breast milk, and liquid forms (e.g., sodas) overwhelm metabolic shields more than solid fruits.Macrophages may hold keys to diseases from atherosclerosis to cancer; deleting GLUT5 in microglia reverses fructose's effects, hinting at evolutionary roles in aging or low-oxygen states.Related content:M&M 215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary PattiArticle | Dietary Fructose & Metabolic Health: An Evolutionary PerspectiveReference Paper:Study | Early life high fructose impairs microglial phagocytosis and neurodevelopment*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts
Send us a textIn this inspiring episode, Anne E. Goldfeld, MD—physician-scientist, humanitarian, and recipient of the 2025 Jimmy and Rosalynn Carter Humanitarian Award—joins Marla Dalton, CAE, and William Schaffner, MD, to reflect on a remarkable career in medicine, science, and global health. From treating patients in refugee camps along the Thai-Cambodian border to conducting groundbreaking research at Harvard Medical School and Boston Children's Hospital, Goldfeld shares the path that led her to a career that is tackling 2 of the greatest epidemics of our time: tuberculosis and HIV/AIDS.Show NotesA native Californian, Dr. Goldfeld attended Brown University and the University of California, Berkeley, and earned her medical degree from Albert Einstein College of Medicine. She completed her internship and residency in internal medicine and a clinical fellowship in infectious diseases at the Massachusetts General Hospital followed by a postdoctoral research training in molecular biology at Harvard University. She is Professor of Medicine and Pediatrics at Harvard Medical School and a Senior Investigator in the Program in Cellular and Molecular Medicine at Boston Children's Hospital, where her research laboratory is located. She is also Professor of Immunology and Infectious Disease at the Harvard TH Chan School of Public Health and a physician in the infectious disease division of Brigham and Women's Hospital. On the frontlines of the TB and AIDS crises, Dr. Goldfeld co founded transformative treatment and research programs—bringing care to some of the world's most underserved populations—that have led to fundamental discoveries that have saved countless lives.Follow NFID on social media
In August 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria. We chat with delegates about their research and impressions of the meeting. They discuss the most memorable research presented and their experiences in Austria.
Mast cell activation syndrome (MCAS) is a confusing and often misunderstood condition. If you've ever wondered about MCAS symptoms, serum tryptase testing, or how treatments like antihistamines, sodium cromolyn, and even omalizumab fit in, this episode is here to help. We review the findings from “Management of indolent mastocytosis and mast cell activation syndrome - A clinical yardstick,” published in June 2025 in The Annals of Allergy, Asthma & Immunology. Because the paper covers both diseases, we've split it into two parts. This episode focuses on mast cell activation syndrome (MCAS). GET THE INFOGRAPHIC - summary of this episode What we cover in our episode about mast cell activation syndrome: Yardsticks explained: Why the ACAAI uses yardsticks as practical, interim guidelines before full consensus statements are available. Classifying mast cell disorders: Primary (clonal), secondary (allergy/autoimmune), and idiopathic (MCAS). MCAS diagnosis criteria: Symptoms in 2 or more organ systems, objective evidence (serum tryptase or urinary metabolites tests), and positive response to therapy. Treatment strategies: Include trigger avoidance, H1/H2 antihistamines, leukotriene blockers, mast cell stabilizers (such as cromolyn and aspirin), off-label biologics like omalizumab, and epinephrine. Neuropsychiatric symptoms: Brain fog, anxiety, and depression are common and require multidisciplinary management. The Itch Review, hosted by Dr. Gupta, Kortney, and Dr. Blaiss, explores allergy and immunology studies, breaking down complex research in conversations accessible to clinicians, patients, and caregivers. Each episode provides key insights from journal articles and includes a one-page infographic in the show notes for easy reference. Made in partnership with The Allergy & Asthma Network. Thanks to Blueprint Medicines for sponsoring today's episode. This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.
About this episode: Back-to-back crises of the opioid epidemic and COVID-19 have pummeled American communities, eroding trust in public health. But what if restoring that trust could start with a simple conversation? In this episode: Maggie Bartlett shares how she's using her platform as co-host of the podcast, “Why Should I Trust You?”, to forge human connections with those who feel left out of public health conversations and to debunk misinformation about measles, vaccines, and corporate influence. Watch the video episode on YouTube: https://youtu.be/zCx9YY9EBWk Guest: Maggie L. Bartlett, PhD, is an assistant research professor in Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health and the co-host of “Why Should I Trust You?”. Host: Lindsay Smith Rogers, MA, is the producer of the Public Health On Call podcast, an editor for Expert Insights, and the director of content strategy for the Johns Hopkins Bloomberg School of Public Health. Show links and related content: Inside A Rare Conversation Between MAHA Grassroots and Public Health Leaders—Why Should I Trust You? What I'm Learning from MAHA—Your Local Epidemiologist Why Should I Trust You?—www.whyshoulditrustyou.net Transcript Information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @PublicHealthPod on Bluesky @JohnsHopkinsSPH on Instagram @JohnsHopkinsSPH on Facebook @PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.
In this episode host Marc Goldberg interviews Rogue Community College (RCC) and Southern Oregon University (SOU) graduate Jahna Thompson, Rogue Community College president, Dr. Randy Weber and Director, Postsecondary Success at The Ford Family Foundation, Denise Callahan. Jahna emphasizes the value of strong faculty mentorship and advising from her student experience at both Rogue Community College and SOU with a unique lens of having taught in her field of study at both institutions as a faculty/professor over the past year. She elaborates on her academic journey that began taking GED prep classes at RCC and after completing her Bachelor's and Master's degrees, she is currently pursuing a PhD in Immunology & Infectious Disease at Washington State University.President Weber reflects on Jahna's interview and describes specific college efforts through responsive programming, student supports and community partnerships that have helped increase enrollment and improve retention and completion outcomes for students, including those who enter the college taking adult education courses. Denise highlights the Foundation's impactful postsecondary education work across Oregon, particularly in rural communities, through Foundation investments, scholarships and research. She describes how the Foundation's work supporting over 1000 postsecondary education students annually across Oregon through scholarships helps inform the organization's policy and research work and shares more on the recently released Oregon by the Numbers report by the Foundation that offers a detailed profile for each of Oregon's 36 counties. The All In: Student Pathways Forward podcast is a part of Oregon's participation in the National Skills Coalition SkillSPAN network.
Measles is becoming an important public health problem and it is important to recognize and understand the origins of this problem and how it can affect the population of our country. At the same time, it is critical to have updated and scientifically accurate information on the clinical presentations, risk factors and countermeasures. Today, we will discuss this topic with experts in field. Watch this episode: https://youtu.be/oQDaa8J9v5w Topics: • Define measles as an important public health threat • Explain the origin of the epidemic • Accurate information on countermeasures and strategies to tackle this outbreak. Guests: - Hana Mohammed El Sahly, M.D. Professor, Kyle and Josephine Morrow Chair, Department of Medicine, Molecular Virology and Microbiology; Vaccine and Treatment Evaluation Unit (VTEU) Baylor College of Medicine Houston, TX US. - Natasha B. Halasa M.D., M.P.H. Craig Weaver Professor of Pediatrics, Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University, Nashville Tennessee This episode is brought to you by the Antimicrobial Agents and Chemotherapy journal available at https://asm.org/aac. If you plan to publish in AAC, ASM Members get up to 50% off publishing fees. Visit https://asm.org/joinasm to sign up. Visit https://asm.org/aac to browse issues and/or submit a manuscript. Follow Cesar on twitter at https://twitter.com/SuperBugDoc for AAC updates. Subscribe to the podcast at https://asm.org/eic
ReferencesGuerra, DJ. 2025. Unpublished lecturesTrends in Immunology. REVIEW.2017. V. 38, ISSUE 4, P287-297, APRIL 01.Nat Rev Genet. 2025 Jan;26(1):7-30.Bruce/Clapton/Baker. 1968. Wheels of Fire lp. Cream.https://music.youtube.com/playlist?list=OLAK5uy_kFv6q_z5W4BZfkKZDowVKYyxdWi6mR_Yc&si=ruW790pL_RybELtS
Immune discusses how cancer cells swap mitochondria with T cells and then digs in for a discussion of an unusual checkpoint blockade that failed for cancer but could be repurposed for autoimmune inflammation. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Cancer cells steal mitochondria from neurons for metastasis (Nature 2025) Cancer cells donate damaged mitochondria to T cells to impair them (Nature 2025) PD-L1 binding to CD80 on the same dendritic cell needed for migration (Sci Adv 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
Dr. Mike Pistiner is not just an allergist and immunologist, he's also an allergy dad and fierce patient advocate. In this episode, Dr. Mike breaks down what allergies are, typical signs and symptoms and how they're treated. Have you been curious about when is the right time to use epinephrine? Then this episode is for YOU! Tune in today!Michael Pistiner, MD, MMSc is Director of Food Allergy Advocacy, Education and Prevention for the MassGeneral Hospital for Children, Food Allergy Center. He has a special interest in food allergy and anaphylaxis education and advocacy, infant food allergy management, healthcare provider education, facilitating collaborations between the medical home and school health, and maintaining quality of life in children (and their families) with food allergies. Dr. Mike is author of "Everyday Cool With Food Allergies", co-author of the "Living Confidently With Food Allergy" handbook, and co-founder and content creator of AllergyHome.org.Dr. Pistiner is a fellow in the American Academy of Pediatrics (AAP), where he is a member of the Section on Allergy and Immunology Executive Committee, Council on School Health and the Massachusetts Chapter of the AAP. He is also a member of the American Academy of Allergy Asthma & Immunology and the American College of Allergy, Asthma and Immunology.Additionally, he serves on the medical advisory board of Asthma & Allergy Foundation of America, New England Chapter and is a voluntary consultant for the Massachusetts Department of Public Health School Health Service Unit.To learn more about the Food Allergy Management Bootcamp at MassGeneral visit: https://www.massgeneral.org/children/food-allergies/food-allergy-management-boot-campTo learn more about the FAMP-It resource visit: https://famp-it.org/
Ina Stelzer, Ph.D., explores how the maternal immune system adapts to support a healthy pregnancy and how disruptions can lead to complications like preterm birth. Her lab identifies early immune changes linked to spontaneous preterm birth and investigates the role of the maternal brain in regulating immune responses. Stelzer uses advanced technologies like mass cytometry and spatial proteomics to map immune and molecular changes in pregnancy, integrating these data with transcriptomics and mouse models. Her team studies how antidepressants affect immune signaling during pregnancy and examines the impact of social and behavioral factors. These insights may reveal biomarkers and therapeutic targets for improving maternal and fetal health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40773]
In 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria, and recorded daily episodes discussing highlights of the conference. Here is the final of five special episodes from the meeting, in which Brenda and Jason discuss sessions on AI applications and CAR T therapy progress.
In 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria, and recorded daily episodes discussing highlights of the conference. Here is the fourth of five special episodes from the meeting, in which Jason and Brenda discuss sessions on cancer immunotherapy and neuroimmunology.
Over 50 million Americans suffer from a range of frustrating allergy symptoms from hay fever to asthma, hives to sinusitis. Many have tried medications, visited allergists, and used various treatments, desperate to find a reliable way to alleviate their pain, but just can't seem to get the dependable relief they need. Now, one of New York's top allergists, Dr. Dean Mitchell, lifts the cloud of mystery surrounding allergies and offers a breakthrough new treatment program that will dramatically lessen their severity, if not cure them for good. In Dr. Dean Mitchell's Allergy and Asthma Solution, Mitchell clearly and comprehensively explains what allergies are, why they are so prevalent, and all of the standard treatments. He then presents a cutting edge 5-step program for reversing allergies called sublingual immunotherapy, or "allergy drops." This new treatment, widely accepted in Europe but still relatively unknown in the United States, is painless, convenient, incredibly effective, and completely safe since it works naturally through the body's immune system. Even better, it can be customized to meet specific needs, is shot-free, and can be self-administered. Dr. Dean Mitchell's Allergy and Asthma Solution is the best guide to understanding allergies and overcoming their symptoms.Dean Mitchell, MD, is the leading expert in sublingual allergy immunotherapy in the United States. He had been in practice for seven years following the conventional methods of allergy cures when he first learned of sublingual allergy immunotherapy (allergy drops) and has been one of its strongest proponents. He now runs a private practice, Ocean Allergy & Nutrition, in Manhattan. Dr. Mitchell's patients come from all over the US to receive his treatments. He is a fellow of the American College of Allergy, Asthma, and Immunology and is a member of the Joint Council of Allergy and Immunology.For ten years he was a clinical instructor of medicine at Columbia College of Physicians and Surgeons. He graduated from Brown University in 1982 and received his MD from the Sackler School of Medicine at Tel Aviv University in 1986. He lives in Long Island with his wife and two sons. When he's not busy with his patients, he enjoys playing baseball with his kids.https://www.mitchellmedicalgroup.com/about/dr-dean-mitchell/?utm_source=google&utm_medium=referral&utm_campaign=gmb_dean?utm_source=GMB&utm_medium=DeanBecome a supporter of this podcast: https://www.spreaker.com/podcast/earth-ancients--2790919/support.
In today's episode, supported by Daiichi-Sankyo, we spoke with Ronan J. Kelly, MD, MBA, FASCO; and Michelle Shiller, DO, AP/CP, MGP, about HER2 immunohistochemistry (IHC) testing in non–small cell lung cancer (NSCLC). Kelly is director of the Charles A. Sammons Cancer Center and chief science officer at Baylor University Medical Center in Dallas, Texas; the W.W. Caruth Jr. Endowed Chair of Immunology at Baylor University Medical Center; chief of Oncology at Baylor Scott & White Health System; founder and medical director of the Texas Cancer Interception Institute; a clinical professor at the Texas A&M University College of Medicine; an adjunct associate professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore, Maryland; and a professor in the Clinical Sciences Division at the Translational Genomics Research Institute in Phoenix, Arizona. Shiller is a molecular genetic pathologist at Baylor University Medical Center. In our conversation, Drs Kelly and Shiller discussed the importance of performing IHC testing for HER2 in NSCLC, how IHC results may influence treatment decision-making beyond the scope of next-generation sequencing results, and recommendations for more efficient and collaborative IHC testing implementation in clinical practice.
This week on The Marathon Running Podcast, we tackle the most misunderstood phase of marathon training: the taper. Host [Insert Host Name Here] compares this final stage to the difference between cramming and consolidating for a major exam, sharing a personal story about how his own failed taper taught him the hard way that less is truly more. For solo runners like Letty, mastering the taper is especially crucial, as it's the final step to ensure your body is primed for an independent race. We dive into the science of supercompensation, explaining how resting unlocks your full physiological potential by rebuilding muscle, replenishing glycogen, and boosting your immune system.Whether you're battling the "taper crazies" or feeling anxious about the reduced mileage, this episode is a deep dive into the practical blueprint and mental strategies you need to arrive at the starting line feeling strong, confident, and ready for your best race. Trust the process, because the taper isn't about losing fitness—it's about unlocking it for that final, glorious solo effort.Here are our research citations:
In this episode of the Fertility Confidence podcast, Kelsey Duncan addresses listener questions covering a range of topics including male factor fertility, reproductive immunology, AMH levels, and natural cycle IVF. She emphasizes the importance of understanding male fertility metrics, the role of immunology in fertility treatments, and the misconceptions surrounding AMH levels. Kelsey also discusses the potential benefits of natural cycle IVF and the significance of community support for individuals navigating their fertility journeys. Thank you to our amazing podcast sponsor, Needed. Check out their TTC and pregnancy products at thisisneeded.com and use the code DRKELSEY for 20% off your first order. 00:00 Introduction and Overview of Topics 03:11 Understanding Male Factor Fertility 05:51 Exploring Reproductive Immunology 13:50 The Controversy of AMH Levels 19:54 Natural Cycle IVF and Its Benefits 27:08 Community Support in Fertility Journeys
Cindy talks with Shane Crotty about his teenage days driving 3 ½ hours every weekend to have his first research experience in marine biology, how that eventually led to studying how vaccines work and how we can make them better, and how immunology research and publishing got a turbo-boost during the pandemic. Hosts: Cindy Leifer Guest: Shane Crotty Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune 85 discusses Crotty lab paper on human upper airway immunity Shane Crotty on TWiV657 SARS-CoV-2 immunity Shane Crotty on TWiV684 Persistence of SARS-CoV memory Shane on TWiV802 Another epitope Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.