Podcasts about Network

The CLAIR Model: A Synthesized Conceptual Framework for Mapping Critical Infrastructure Interdependencies [Guest Diary] https://isc.sans.edu/diary/The+CLAIR+Model+A+Synthesized+Conceptual+Framework+for+Mapping+Critical+Infrastructure+Interdependencies+Guest+Diary/32748 Cisco Catalyst SD-WAN Controller Authentication Bypass Vulnerability CVE-2026-20127 https://sec.cloudapps.cisco.com/security/center/content/CiscoSecurityAdvisory/cisco-sa-sdwan-rpa-EHchtZk https://blog.talosintelligence.com/uat-8616-sd-wan/ Abusing Cortex XDR Live https://labs.infoguard.ch/posts/abusing_cortex_xdr_live_response_as_c2/ OpenSSL Vulnerability CVE-2025-15467 https://seclists.org/oss-sec/2026/q1/220

In honor of the late Robert Duvall, we share Adam and Josh's March, 2021 review of Sidney Lumet's Best Picture-nominated NETWORK, which was part of the 7 From '76 series. For full access to the show archive, Filmspotting Discord, monthly bonus episodes, and more, ⁠join the Filmspotting Family⁠⁠.See omnystudio.com/listener for privacy information.

In this episode of The PDB Afternoon Bulletin: Western intelligence officials warn that Iran could direct proxy terror attacks across Europe if the United States launches military strikes against Tehran — tapping networks with proven operational history on the continent and raising concerns about asymmetric retaliation. Russian operatives are reportedly acquiring properties near military bases across Europe, creating what intelligence officials describe as a covert network of “Trojan horse” sites potentially positioned for sabotage and hybrid warfare. To listen to the show ad-free, become a premium member of The President's Daily Brief by visiting https://PDBPremium.com. Please remember to subscribe if you enjoyed this episode of The President's Daily Brief. YouTube: youtube.com/@presidentsdailybrief Cardiff: Get fast business funding without bank delays—apply in minutes with Cardiff and access up to $500,000 in same‑day funding at https://Cardiff.co/PDB  American Financing: Call American Financing today to find out how customers are saving an avg of $800/mo. NMLS 182334, https://nmlsconsumeraccess.org APR for rates in the 5s start at 6.196% for well qualified borrowers. Call 866-885-1881 for details about credit costs and terms. Visit http://www.AmericanFinancing.net/PDB Learn more about your ad choices. Visit megaphone.fm/adchoices

Open Redirects: A Forgotten Vulnerability? https://isc.sans.edu/diary/Open%20Redirects%3A%20A%20Forgotten%20Vulnerability%3F/32742 Goodbye innerHTML, Hello setHTML: Stronger XSS Protection in Firefox 148 https://hacks.mozilla.org/2026/02/goodbye-innerhtml-hello-sethtml-stronger-xss-protection-in-firefox-148/ More telnetd issues https://seclists.org/oss-sec/2026/q1/199

Just last week, we asked about Phil Spencer and why he's been so quiet lately. Now we know why! Also, OneDrive for the Mac is finally going to look like it belongs on the Mac. And Google Chrome finally picks up a split view like the rest of the planet, plus a few other new features. PHIL SPENCER OUT AT XBOX Phil Spencer has retired from Microsoft and his heir-apparent, Sarah Bond, left Microsoft as well Report details the Xbox reorg Ex-Xbox executive issues an old guy shouting at sky assessment New Microsoft Gaming CEO discusses "return to Xbox" Hot-take: This person seems unqualified to run Xbox/MS Gaming, but let's give her a chance Alternative hot-take: She is literally here to wind down this business, which makes no sense... unless there's a spin-off Windows WSJ report sheds some light, and adds a lot of confusion, to Nvidia's Windows PC plans Week D arrived on time this month Preview of March Patch Tuesday updates Network speed test, pan and tilt in Camera settings, sysmon, RSAT improvements, Quick Machine Recovery improvements, WEBP background image support, Emoji 16.0 And you thought the Canary channel was weird already -New builds for Canary, Dev, and Beta. Canary gets features we already saw elsewhere, Dev and Beta get context menu, settings, and Taskbar improvements Paul has published (an incomplete version of) De-Enshittify Windows 11 De-enshittifying Copilot and AI is doable but not yet automated What about the alternatives? Next step: Security and Apps chapters HP revenues up 6.9 percent to $14.4 billion but RAM warning is more dire than expected Apple to add multitouch to MacBook Pro lineup in late 2026. Oh the irony AI Xbox February update brings 1440p streaming to Xbox consoles, updates for Xbox ROG Ally, more Xbox app is delivering post-game recaps on Windows 11 for Insiders EA had the most game downloads on PC and console in 2025, thanks to having the three most popular AAA games of the year (BF6, EA Sports FC 25, and EA Sports FC 26). Microsoft was number two, followed by Take-Two, Ubisoft, and Sony. Fortnite is somehow still the biggest game overall on console, and Counter-Strike 2 (!!!!) is the biggest on PC. 20 million Fortnite players on PS, 15 million on Xbox Tips and picks Tip of the week: OneDrive for the Mac App pick of the week: Google Chrome RunAs Radio this week: SaaS on Multiple Clouds with Steve Buchanan Brown liquor pick of the week: Sons of Vancouver Wheated Rye Whisky Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Download or subscribe to Windows Weekly at https://twit.tv/shows/windows-weekly Check out Paul's blog at thurrott.com The Windows Weekly theme music is courtesy of Carl Franklin. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: bitwarden.com/twit zscaler.com/security

Just last week, we asked about Phil Spencer and why he's been so quiet lately. Now we know why! Also, OneDrive for the Mac is finally going to look like it belongs on the Mac. And Google Chrome finally picks up a split view like the rest of the planet, plus a few other new features. PHIL SPENCER OUT AT XBOX Phil Spencer has retired from Microsoft and his heir-apparent, Sarah Bond, left Microsoft as well Report details the Xbox reorg Ex-Xbox executive issues an old guy shouting at sky assessment New Microsoft Gaming CEO discusses "return to Xbox" Hot-take: This person seems unqualified to run Xbox/MS Gaming, but let's give her a chance Alternative hot-take: She is literally here to wind down this business, which makes no sense... unless there's a spin-off Windows WSJ report sheds some light, and adds a lot of confusion, to Nvidia's Windows PC plans Week D arrived on time this month Preview of March Patch Tuesday updates Network speed test, pan and tilt in Camera settings, sysmon, RSAT improvements, Quick Machine Recovery improvements, WEBP background image support, Emoji 16.0 And you thought the Canary channel was weird already -New builds for Canary, Dev, and Beta. Canary gets features we already saw elsewhere, Dev and Beta get context menu, settings, and Taskbar improvements Paul has published (an incomplete version of) De-Enshittify Windows 11 De-enshittifying Copilot and AI is doable but not yet automated What about the alternatives? Next step: Security and Apps chapters HP revenues up 6.9 percent to $14.4 billion but RAM warning is more dire than expected Apple to add multitouch to MacBook Pro lineup in late 2026. Oh the irony AI Xbox February update brings 1440p streaming to Xbox consoles, updates for Xbox ROG Ally, more Xbox app is delivering post-game recaps on Windows 11 for Insiders EA had the most game downloads on PC and console in 2025, thanks to having the three most popular AAA games of the year (BF6, EA Sports FC 25, and EA Sports FC 26). Microsoft was number two, followed by Take-Two, Ubisoft, and Sony. Fortnite is somehow still the biggest game overall on console, and Counter-Strike 2 (!!!!) is the biggest on PC. 20 million Fortnite players on PS, 15 million on Xbox Tips and picks Tip of the week: OneDrive for the Mac App pick of the week: Google Chrome RunAs Radio this week: SaaS on Multiple Clouds with Steve Buchanan Brown liquor pick of the week: Sons of Vancouver Wheated Rye Whisky Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Download or subscribe to Windows Weekly at https://twit.tv/shows/windows-weekly Check out Paul's blog at thurrott.com The Windows Weekly theme music is courtesy of Carl Franklin. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: bitwarden.com/twit zscaler.com/security

A funeral director turned therapist on meaning-making, unfinished business, and why grief needs more truth and less cheerleading. Ready for a life-affirming episode about death? I'm excited to introduce you to my longtime friend Rachel Hauck. She's a funeral director and embalmer. After 20 years in business, she's decided to go back to school to become a therapist. I love chatting with people who are in midlife career shifts. Why did she make the switch? How will her previous career shape her identity as a therapist?  What sets this conversation apart from the hushed, almost embarrassed way folks often talk about death is our openness around its emotional messiness. We go beyond Kübler-Ross's model to consider those carrying complex or "untraditional" feelings of grief (think: Jeanette McCurdy). All experiences are welcome here.  GUEST BIO Rachel Hauck (she/her) has served families as a licensed funeral director/embalmer in the state of Florida for the last 20 years.  She is currently completing a master's degree in Clinical Mental Health Counseling at Nova Southeastern University and hopes to develop a signature program in prolonged grief therapy.  Join our Authentic Leaders Group! Next cohort starts May 1, 2026. This is a journey of self-discovery and leadership mastery, where you'll not only enhance your leadership skills but also forge meaningful connections with fellow therapists who are committed to their own growth and the betterment of the therapy field. Apply now! Thank you to The Therapist Network for sponsoring the show! The Therapist Network is a global community built by and for therapists. You'll find live consult groups, an ever-growing library of workshops and courses, plus a community that really sees you. Sarah's group, Tending to the Wounded Healer, meets every other Monday from 1–2pm CT, and it's a space to explore the intersection of your lived experience and your clinical work. So if you want to feel more supported and less alone, visit TheTherapist.Network—or join Sarah's group directly at tinyurl.com/HealerConsultTTN. SUPPORT THE SHOW Conversations With a Wounded Healer Merch Join our Patreon for gifts & perks Shop our Bookshop.org store and support local booksellers Share a rating & review on Apple Podcasts *** Let's be friends! You can find me in the following places… Website Facebook @headheartbiztherapy Instagram @headheartbiztherapy  

Just last week, we asked about Phil Spencer and why he's been so quiet lately. Now we know why! Also, OneDrive for the Mac is finally going to look like it belongs on the Mac. And Google Chrome finally picks up a split view like the rest of the planet, plus a few other new features. PHIL SPENCER OUT AT XBOX Phil Spencer has retired from Microsoft and his heir-apparent, Sarah Bond, left Microsoft as well Report details the Xbox reorg Ex-Xbox executive issues an old guy shouting at sky assessment New Microsoft Gaming CEO discusses "return to Xbox" Hot-take: This person seems unqualified to run Xbox/MS Gaming, but let's give her a chance Alternative hot-take: She is literally here to wind down this business, which makes no sense... unless there's a spin-off Windows WSJ report sheds some light, and adds a lot of confusion, to Nvidia's Windows PC plans Week D arrived on time this month Preview of March Patch Tuesday updates Network speed test, pan and tilt in Camera settings, sysmon, RSAT improvements, Quick Machine Recovery improvements, WEBP background image support, Emoji 16.0 And you thought the Canary channel was weird already -New builds for Canary, Dev, and Beta. Canary gets features we already saw elsewhere, Dev and Beta get context menu, settings, and Taskbar improvements Paul has published (an incomplete version of) De-Enshittify Windows 11 De-enshittifying Copilot and AI is doable but not yet automated What about the alternatives? Next step: Security and Apps chapters HP revenues up 6.9 percent to $14.4 billion but RAM warning is more dire than expected Apple to add multitouch to MacBook Pro lineup in late 2026. Oh the irony AI Xbox February update brings 1440p streaming to Xbox consoles, updates for Xbox ROG Ally, more Xbox app is delivering post-game recaps on Windows 11 for Insiders EA had the most game downloads on PC and console in 2025, thanks to having the three most popular AAA games of the year (BF6, EA Sports FC 25, and EA Sports FC 26). Microsoft was number two, followed by Take-Two, Ubisoft, and Sony. Fortnite is somehow still the biggest game overall on console, and Counter-Strike 2 (!!!!) is the biggest on PC. 20 million Fortnite players on PS, 15 million on Xbox Tips and picks Tip of the week: OneDrive for the Mac App pick of the week: Google Chrome RunAs Radio this week: SaaS on Multiple Clouds with Steve Buchanan Brown liquor pick of the week: Sons of Vancouver Wheated Rye Whisky Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Download or subscribe to Windows Weekly at https://twit.tv/shows/windows-weekly Check out Paul's blog at thurrott.com The Windows Weekly theme music is courtesy of Carl Franklin. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: bitwarden.com/twit zscaler.com/security

Just last week, we asked about Phil Spencer and why he's been so quiet lately. Now we know why! Also, OneDrive for the Mac is finally going to look like it belongs on the Mac. And Google Chrome finally picks up a split view like the rest of the planet, plus a few other new features. PHIL SPENCER OUT AT XBOX Phil Spencer has retired from Microsoft and his heir-apparent, Sarah Bond, left Microsoft as well Report details the Xbox reorg Ex-Xbox executive issues an old guy shouting at sky assessment New Microsoft Gaming CEO discusses "return to Xbox" Hot-take: This person seems unqualified to run Xbox/MS Gaming, but let's give her a chance Alternative hot-take: She is literally here to wind down this business, which makes no sense... unless there's a spin-off Windows WSJ report sheds some light, and adds a lot of confusion, to Nvidia's Windows PC plans Week D arrived on time this month Preview of March Patch Tuesday updates Network speed test, pan and tilt in Camera settings, sysmon, RSAT improvements, Quick Machine Recovery improvements, WEBP background image support, Emoji 16.0 And you thought the Canary channel was weird already -New builds for Canary, Dev, and Beta. Canary gets features we already saw elsewhere, Dev and Beta get context menu, settings, and Taskbar improvements Paul has published (an incomplete version of) De-Enshittify Windows 11 De-enshittifying Copilot and AI is doable but not yet automated What about the alternatives? Next step: Security and Apps chapters HP revenues up 6.9 percent to $14.4 billion but RAM warning is more dire than expected Apple to add multitouch to MacBook Pro lineup in late 2026. Oh the irony AI Xbox February update brings 1440p streaming to Xbox consoles, updates for Xbox ROG Ally, more Xbox app is delivering post-game recaps on Windows 11 for Insiders EA had the most game downloads on PC and console in 2025, thanks to having the three most popular AAA games of the year (BF6, EA Sports FC 25, and EA Sports FC 26). Microsoft was number two, followed by Take-Two, Ubisoft, and Sony. Fortnite is somehow still the biggest game overall on console, and Counter-Strike 2 (!!!!) is the biggest on PC. 20 million Fortnite players on PS, 15 million on Xbox Tips and picks Tip of the week: OneDrive for the Mac App pick of the week: Google Chrome RunAs Radio this week: SaaS on Multiple Clouds with Steve Buchanan Brown liquor pick of the week: Sons of Vancouver Wheated Rye Whisky Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Download or subscribe to Windows Weekly at https://twit.tv/shows/windows-weekly Check out Paul's blog at thurrott.com The Windows Weekly theme music is courtesy of Carl Franklin. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Sponsors: bitwarden.com/twit zscaler.com/security

Nineteen Seventy-Six. America's bicentennial was a great year for cinema, with films like A Star is Born, King Kong, All the President's Men, Carrie, and The Omen heating up the box office, and instant classics Rocky and Network earning the most accolades. After a six-decade career in the director's chair, Alfred Hitchcock released his last film, Family Plot, around the same time that an up-and-coming young director by the name of Martin Scorsese released his breakout hit, the fifth film of his budding career. Centered on a disillusioned New York cabbie played by Robert De Niro, this rain-and-neon-soaked meditation on summer in the city proved to be a defining outing by both actor and director. With a cast including Cybill Shephard, Albert Brooks, Peter Boyle, Harvey Keitel, and a very young Jodie Foster, the film racked up awards, including the Palme d'Or at Cannes and four nominations at the Academy Awards, including Best Picture, Best Actor for De Niro, and Best Supporting Actress for Foster. Despite controversies over its content, the film was hailed as a hit. Now, fifty years later, we're catching a ride with Taxi Driver and talking to you about it!   For more geeky podcasts visit GonnaGeek.com    You can find us on iTunes under ''Legends Podcast''. Please subscribe and give us a positive review. You can also follow us on Twitter @LegendsPodcast or even better, send us an e-mail: LegendsPodcastS@gmail.com    You can write to Rum Daddy directly: rumdaddylegends@gmail.com    You can find all our contact information here on the Network page of GonnaGeek.com Our complete archive is always available at www.legendspodcast.com, www.legendspodcast.libsyn.com    Show Music:Danger Storm by Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 https://creativecommons.org/licenses/by/4.0/

Sylvia Pizarroso is a finance veteran with over 30 years of experience in commercial and business banking. Known for her expertise in business development, client relationship management, and risk mitigation, Sylvia has a strong background in credit analysis, cash management, and SBA lending. She has served as a trusted advisor to businesses of all sizes throughout her career. Sylvia holds a bachelor's degree in business administration with a concentration in Finance. In April 2024, Sylvia joined the OCIE Small Business Development Center (OCIE SBDC) as the Finance Center Director. She came to the SBDC after a distinguished 14-year tenure at JP Morgan Chase, where she held several leadership positions, most recently as Executive Director in their Commercial Banking division. As Finance Center Director, Sylvia leads a team dedicated to providing critical financial support and guidance to small businesses. Her leadership extends to the community as demonstrated by her service as the 2022-2024 Board Chair of the Orange County Hispanic Chamber of Commerce. Deeply committed to empowering Latino youth, Sylvia is actively involved in mentoring and community outreach. She serves as the Mentorship Program Advisor for the Orange County Hispanic Youth Chamber of Commerce and is a board member of the Orangewood Foundation, an organization supporting youth transitioning out of the foster care system. An immigrant from La Paz, Bolivia, Sylvia's personal journey embodies the American dream. Her drive and dedication have fueled her success, and she is passionate about helping others achieve their professional and personal dreams. Sylvia is married and has two children, Michelle and Luke.   -- Critical Mass Business Talk Show is Orange County, CA's longest-running business talk show, focused on offering value and insight to middle-market business leaders in the OC and beyond. Hosted by Ric Franzi, business partner at REF Orange County. Learn more about Ric at www.ricfranzi.com.

Kevin reacts to the State of the Union address and reviews some of the highlights. Kevin also covers the following stories: last Friday the U.S. Commerce Department (CD) reported the 4th Quarter Gross Domestic Product; the CD's Bureau of Economic Analysis released the Personal Consumption Expenditures; the Conference Board reported February Consumer Confidence; Kevin talked about joining Dan Caroll during the previous afternoon on a show to talk about CDL Mills, enforcement of English Language Proficiency requirements and Chameleon Carrier Networks; Kevin has the details, digs into the data, puts the information into historical perspective, offers his insights and opinions.

Kevin reacts to the State of the Union address and reviews some of the highlights. Kevin also covers the following stories: last Friday the U.S. Commerce Department (CD) reported the 4th Quarter Gross Domestic Product; the CD's Bureau of Economic Analysis released the Personal Consumption Expenditures; the Conference Board reported February Consumer Confidence; Kevin talked about joining Dan Caroll during the previous afternoon on a show to talk about CDL Mills, enforcement of English Language Proficiency requirements and Chameleon Carrier Networks; Kevin has the details, digs into the data, puts the information into historical perspective, offers his insights and opinions. See omnystudio.com/listener for privacy information.

Your mouth will be watering for this bonus February episode! Eric Dell, President and CEO of American Bakers Association and CAPS team member, Nate Clayberg, jump on the podcast to share the incredible partnership they have been forming on behalf of the commercial baking industry and the CAPS Network. Did you know that the commercial baking industry needs just about every job sector: business managers, engineers, computer specialists, marketers and yes even health care and science professionals? The baking industry has something for everyone!Check out bakingworks.org for more ways to connect to this exciting industry!The Network is all about discovering the CAPS Model. The CAPS Network is a 501(c)3 supporting over 130 programs, in 20+ states and 4 countries. CAPS reimagines education to be a learner centered, profession based experience that catapults young people into passion and purpose. CAPS is going where students lead.Find us!Twitter: @capsnetLinkedIn: CAPS NetworkFacebook: CAPS NetworkInstagram: @capsnetwork

Batman ’66 S2 Ep59 – Ice Spy Mr. Freeze is back in town, and has plans to build an icy weapon that will have the world at his control. With help from Glacia Glaze, the renowned ice skater, he captures Professor Isaacson and tries to extract the secret formula for instant ice from him. Mr. […] The post BatChums Episode 95 – Ice Spy appeared first on The ESO Network.

Joe discusses the Doctor Who episode The Fires of Pompeii and Toni makes some noise. If you’re interested in being a Friend of Rassilon, click here. Download • YouTube • RSS • Patreon • iTunes • Google Play • ESO Network The post The Watch-A-Thon of Rassilon: Episode 195: The Fires of Pompeii (The Rule of At Least 3) appeared first on The ESO Network.

In this episode of Disguised Coverage, Anthony discusses several key comments made by Brandon Beane and Joe Brady at the 2026 NFL Combine. Insights into the roster, previous offseason moves, future decisions, and more0:00 | Opening thoughts8:54 | Biggest breadcrumb/theme from Brandon Beane and Joe Brady31:00 | Biggest takeaways from Brandon Beane speaking with the media57:55 | Biggest takeaways from Joe Brady speaking with the media1:28:49 | One more takeaway from Brandon Beane speaking with the media1:33:56 | One Pie Pizza1:36:12 | Closing thoughts and comments from the live chatPresenting Sponsor - One Pie Pizza https://www.onepiepizza.com/ Elevated Catering of Buffalo https://elevatedcateringbuffalo.com/Tell them Cover 1 and Disguised Coverage sent you!!Follow on Twitter: https://twitter.com/Pro__AntFollow on Bluesky: https://bsky.app/profile/proant.bsky.socialCover 1 would love to hear your thoughts on this topic and the show in general. Comment below and let us what you think!One Pass Premium Membership - https://www.cover1.net/onepass/Don't miss out on our PREMIUM CONTENT-Access to detailed Premium Content.-Access to our video library.-Access to our private Slack channel.-Sneak peek at upcoming content.-Exclusive group film room sessions & much more.Thank you for watching this video, we can't do it without the support of our fans. If you have any ideas for content you'd like to see from us, comment below. -DOWNLOAD THE COVER 1 MOBILE APP!► Android: https://play.google.com/store/apps/details?id=com.coverapp► iOS: https://apps.apple.com/us/app/id1532587486► Subscribe to our YouTube channel - https://www.youtube.com/channel/UClL6eJS1s8xmRoYRQbYgxQQ?sub_confirmation=1► Subscribe to our Cover 1 Network channel - https://podcasts.apple.com/us/podcast/cover-1-sports/id1370162953 -Cover 1 provides a multi-faceted analysis of the NFL and NFL Draft including Podcasts, Video blogs, Commentary, Scouting Reports, Highlights, and Video Breakdowns. NFL footage displayed is not owned by Cover 1. -Follow Us HereTwitter: https://twitter.com/Cover1Instagram: https://www.instagram.com/@Cover_1_Facebook: https://www.facebook.com/Cover1NFL/Official Merchandise:https://teespring.com/en-GB/stores/cover-1The Cover1.net website and associated Social Media platforms are not endorsed by, directly affiliated with, maintained, authorized, or sponsored by the NFL or any of its clubs, specifically the Buffalo Bills. All products, marks, and company names are the registered trademarks of their original owners. The use of any trade name or trademark is for identification and reference purposes only and does not imply any association with the trademark holder of their product brand.

Eryck Stamper joins the VET S.O.S. Network to dive into how therapeutic beekeeping is helping veterans and first responders heal from trauma, rediscover purpose, and rebuild life after service.In this episode, we explore:• Military transition challenges and identity after service• How nature-based and agricultural therapy supports mental health• The science and psychology behind beekeeping as healing• How Mission Beelieve provides free programs for veterans nationwideWhether you're navigating military transition, managing PTSD, or searching for non-traditional healing tools, this conversation delivers practical insight and real-world hope.Eryck Stamper is a retired U.S. Navy Senior Chief and Veteran Outreach Coordinator for Mission Beelieve, a nonprofit dedicated to therapeutic beekeeping for veterans, first responders, and families. His work focuses on holistic healing, agriculture-based therapy, and veteran reintegration.The VET S.O.S. Network connects veterans, spouses, and service members with real resources and real people who want to see you thrive.VET S.O.S. VET S.O.S. – Veteran Entrepreneur SpotlightVET S.O.S. – Veteran Educational Resources SpotlightWebsite: vetsospodcast.comX/Twitter: @vetsospodcastLinkedIn: linkedin.com/company/vetsospodcastYouTube: youtube.com/@vetsospodcastFacebook: facebook.com/vetsospodcastInstagram: instagram.com/vetsospodcastTikTok: tiktok.com/@vetsospodcast#VETSOS #GrabTheLifeline #VeteranHealing #VeteranTransition #TherapeuticBeekeeping #MissionBeelieve #HolisticHealth #PTSDSupport #VeteranWellness #MilitaryLife

Blood cancers are the fifth most common group of cancers in the UK. But for a small number of people, the condition may have an inherited genetic cause.  In this episode of Behind the Genes, we explore the role of genetics in blood cancer, and what an inherited risk means for patients and their families. Our guests explain what blood cancer is, how inherited factors can increase risk, and why multidisciplinary teamwork is key to supporting families. They also look ahead to future advances, from whole genome sequencing to prevention trials.  Our host Amanda Pichini, Clinical Director at Genomics England, is joined by:  Dr Katie Snape, Principal Clinician at Genomics England and Consultant Cancer Geneticist  Bev Speight, Principal Genetic Counsellor Dr Sarah Westbury, Consultant Haematologist “By doing whole genome sequencing we get all of the information about all of the changes that might have happened, we know whether any are inherited, but importantly, we're certain of the ones that have just occurred in the cancer cells and can help guide us with their treatment.”  You can download the transcript or read it below. Amanda: Hello, and welcome to Behind the Genes.  Sarah: When we think about blood cancers, it's a whole range of different conditions and when you talk to patients who are affected with blood cancers or are living with them, their experiences are often really different from one another, depending in part on what kind of blood cancer they have.  We also know that blood cancers affect not just the cell numbers but also the way that those cells function, and so the range of symptoms that people can get is really variable.  Amanda: I am your host, Amanda Pichini, clinical director at Genomics England and genetic counsellor.  Today I'll be joined by Dr Katie Snape, principal clinician at Genomics England and a consultant cancer geneticist in London, Bev Speight, a principal genetic counsellor in Cambridge, and Dr Sarah Westbury, and haematologist from Bristol.  They'll be talking about blood cancers and the inherited factors that increase blood cancer risk.  If you enjoy this episode, we'd love your support, so please subscribe, rate and share on your favourite podcast app.  Let's get started.  Thanks to everyone for joining us today on this podcast, we're delighted to have so many experts in the room to talk to us about blood cancer.  I'd love to start with each of you introducing yourself and telling us and the listeners a little bit about your role, so, Sarah, could we start with you?  Sarah: Sure.  It's great to be here.  My name's Sarah Westbury, and I'm a consultant haematologist who works down in Bristol.  And my interest in this area is I'm a diagnostic haematologist so I work in the laboratories here in the hospitals, helping to make a diagnosis of blood cancer for people who are affected with these conditions.  And I also look after patients in clinic who have different forms of blood cancer, but particularly looking after families who have an inherited predisposition to developing blood cancer.  And in the other half of my job, I work as a researcher at the University of Bristol.  And in that part of my job, I'm interested in understanding the genetic basis of how blood counts are controlled and some of the factors that lead to loss of control of those normal blood counts and how the bone marrow functions and works.  Amanda: Thank you.  That's really interesting, we'll be looking forward to hearing more about your experience.  Bev, we'll come to you next.  Bev: Thank you.  Hello everyone, I'm Bev Speight, I'm a genetic counsellor, and I work at Addenbrooke's Hospital in Cambridge.  I work with families with hereditary cancers in the clinical genetic service, and for the last six years or so have been focused on hereditary blood cancers.  So we've been helping our haematologists across the region to do genetic tests and interpret the results, and then in my clinic seeing some of the onward referrals that come to clinical genetics after a hereditary cause for blood cancer is found.  I'm also part of the Council for the UK Cancer Genetics Group.  Amanda: Thank you, Bev.  And Katie, over to you.  Katie: Hello, I'm Katie Snape.  I'm a genetics doctor and I am a specialist in inherited cancer.  So we look after anyone who might have an increased chance of developing cancer in their lifetime due to genetic factors.  I am the chair of the UK Cancer Genetics Group, so that's a national organisation to try and improve the quality of care and care pathways for people with inherited cancer risk in the UK.  And I have a special interest in inherited blood cancers through my work at King's College Hospital, I work in the haematology medicine service there seeing individuals who might have or have been diagnosed as having an inherited component to their blood cancers.  So it's great to be here.  Amanda: Excellent, thank you for those introductions.  I'd like to then dive right in and understand a little bit more about blood cancers.  So, Sarah, could you tell us a little bit more about what blood cancer is?  Sarah: Yes, sure.  The term blood cancer is used to describe a whole range of different kinds of cancer, all of which affect some part of the blood or sometimes parts of the immune system that kind of gets represented as part of the blood.  So it's really describing a big group of conditions rather than one single kind of condition or entity itself.  But like any form of cancer, we understand blood cancers as being conditions where because cells as part of the blood system are rapidly dividing and normally doing so under really well controlled circumstances to produce just the right balance of blood cells and just the right number of those cells.  In a cancer affecting those cells, we see that that loss of control results in either too many of one type of blood cell being produced or too few, or that balance being lost.  And like any form of cancer, this is because of genetic changes that happen in individual cells that then go on to grow in a way that is not controlled and well regulated.    And because when we talk about blood cancer we're talking about such a wide range of different kinds of cancer affecting different cells within that blood system, there's a really wide range of different conditions.  From conditions that we might think of as being like a form of acute leukaemia, so something that produces often symptoms and signs in patients very quickly and they can often feel quite unwell quite soon and then get picked up with having this condition because they present feeling unwell.  All the way to chronic and slow growing cancers that can be found completely by chance and serendipity when blood tests are done for other reasons.  So when we think about blood cancers, it's a whole range of different conditions.  And when you talk to patients who are affected with blood cancers or are living with them, their experiences are often really different from one another, depending in part on what kind of blood cancer they have.  We also know that blood cancers affect not just the cell numbers, but also the way that those cells function.  And so the range of symptoms that people can get is really variable, again depending on which of the blood cells are really affected by that.  And it may be that during the course of some of the conversations we have today in this podcast, we'll perhaps focus on particular kinds of blood cancer.  But like any cancer, it's that disruption of the normal growth and development of cells that means that the number and function of those blood cells has been disrupted in some way.  Amanda: Thank you so much for explaining that, Sarah, that's really helpful.  In terms of across the range of blood cancers, is that something that people can get at any age, and how common is it?  Sarah: It does depend, as we were sort of talking about that really wide range of different disorders that make up that group of blood cancers.  And individually each of those blood cancers is reasonably uncommon compared to cancers that we might typically think of, like breast cancer or colon cancer.  But actually, if you group blood cancers together, they make up quite a sizeable proportion, and they're actually as a group the fifth most common form of cancer that's diagnosed in people in the UK.  In adults in particular we think that perhaps people diagnosed with leukaemia would make up about 3% of the new diagnosis of cancer made in any year.  Amanda: So coming to you, Bev, when we talk about inherited blood cancers, what are the differences between those and blood cancers more generally?    Bev: So at point of diagnosis, it may not be obvious that somebody with a new blood cancer diagnosis is one of the minority of people in that big group as Sarah has described, who has an inherited cause.  So it may not be immediately obvious.  However, in the last few years certainly, it's become more and more routine to do quite broad genetic testing.  Often on a bone marrow sample or blood, because that is done looking for genetic changes, which are part of all cancer and we find within cancer cells, that can help with treatment planning.  It can also find that there is an inherited cause to that new blood cancer diagnosis.  Sometimes that might not be clear cut, sometimes that might be inferred from the genetic tests that are done on the blood or the bone marrow. And the proportion of blood cancers in that huge group which do have an inherited cause is fairly small, the actual proportion will depend a bit on the age of the patient and the specific subtype of blood cancer.  Amanda: Okay, and could you talk us through how some of those inherited genetic factors can increase the chance of a person developing blood cancer, how does that work?  Bev: Yes, so if we know that there is an inherited cause for blood cancer, then what we mean by that most of the time is that a change in a single gene has been found.  And that there is enough research evidence and enough known about that specific change in that gene to say to the person who's been diagnosed, there is at least in part or perhaps a full explanation for why that blood cancer has developed and this could be shared in the family.  So at that point it's information that not only has implications for the person in treatment, but also their relatives.  Depending on what sort of gene alteration it is and which gene it's found in, there are different inheritance patterns, and that changes the sorts of information that we give about risks for relatives.  So for lots of the genetic tests that detect an inherited cause in adults when they're diagnosed, that's most often what we would call an autosomal dominant inheritance pattern.  Essentially that means you only need to have one gene alteration which is in that person's normal non-cancerous DNA inherited from a parent and can be passed onto a child.  And for people in the family who have inherited this one genetic change, then they are likely to be at increased risk of developing blood cancer.  Sometimes with particularly the children's blood cancers, if an inherited cause is found, it can be a different pattern, which we call autosomal recessive.  And that's where two gene changes are found and one has been inherited from each parent.  So parents might be what we call carriers and have one each just by chance, both have been passed onto a child who has developed blood cancer either in childhood or possibly later on, and that's the pattern we call autosomal recessive.  There are other inheritance patterns too.  The third one that we come across being X-linked, and so that has a gender component.  That's where there's a change on the X chromosome, women have two X's, and men have one X and one Y.  So sometimes with the X-linked conditions we're more likely to see the clinical signs of a condition in boys and men because they've only got that one X chromosome.  But those are less common in the context of talking about hereditary blood cancers.  Amanda: Thank you.  That's really helpful to understand.  So it sounds like you're saying that these forms of blood cancers that are caused by a single gene are relatively rare.  And also by having one of these changes, it's not a given that that person will develop a blood cancer, but it makes them more likely, and how likely that is might depend on the inheritance pattern or the type of condition.  Bev: That's right.  So what we're saying is it can give either part of full explanation for the blood cancer diagnosis, and it could confer a risk to family members, but that doesn't mean they definitely will develop it.  We're talking about an increased risk compared to the population risk.  Amanda: Right.  I can imagine for those families to some extent it might be helpful to know the underlying reason why they had that blood cancer, but again, that's just a small proportion.  So, Katie, could I come to you next?  What about the rest of all the blood cancers, how do they occur?  Katie: Yes, thanks, Amanda.  So most blood cancers will occur just by chance.  We also know that there are some environmental factors that can increase the risk of blood cancers, so, for example, serious radiation exposure, something like that.  What Bev has described is where there is this sort of quite rare condition where there is a kind of single gene that's really important for the blood cells in terms of keeping those control mechanisms that Sarah described.  And that's not working properly, which has increased the risk of a blood cancer.  But we also sometimes see some families where there is more blood cancer, or the same type of blood cancer in that family than we might expect by chance.  We think that's probably not due to a single high risk genetic factor, but might be due to kind of multiple lower risk genetic factors that are sort of shared by close family members and can add up together to increase the risk a little bit.  And we call that familial risk or polygenic risk.  We don't have a test for that at the moment.  We wouldn't offer usually any extra screening or testing to those families, but we would just suggest obviously family members are aware of any signs of symptoms of blood cancers and seek any advice if they're concerned.  But, you know, the majority of blood cancers are not due to genetic factors, and it's sort of environmental or chance or bad luck. Amanda: Okay, so it's clear that obviously blood cancer is almost an oversimplification, within that category there's so many different types, so many ways that it could happen in a person.  So, Bev, if we're dealing with that type of blood cancer that is inherited or has some heritability, can you tell us more about what that means for the family?  What kind of impacts do you see that having for them?  Bev: Yes, of course.  So clearly this is another layer of information that's often coming at a family during a time where somebody is often recently diagnosed with blood cancer of one sort or another and is having to take in a lot of information about treatment and all of the uncertainty and anxiety that goes with that.  So for this minority of patients and families where there is new information about an inherited cause, that needs conveying in a timely but sensitive way, bearing in mind what else is happening.  And for some people it can come as a major shock and really an additional burden at that time.  I think the reaction to that will of course depend on lots of factors.  And what we also see is that this question about a new cancer diagnosis of any sort, including blood cancers, can generate the question in people's mind, particularly if they've got children, about does this change the risk for relatives?  So sometimes this new information that, actually, there is an inherited cause is an answer to a question that families have already got.  And that might be because of what Katie's described as familial clustering, there might already have been this known history in the family. So sometimes this information can feed into that and actually be quite a helpful answer.  But it's quite normal for families to feel quite mixed about this and for different family members to have a different approach to it.  When there's the offer of what we would call predictive testing, if we found a change in a single gene in somebody with blood cancer which we're saying is a hereditary cause for that, that might open the door for relatives to access predictive testing.  I.e., the opportunity to discuss and possibly take up a genetic test for themselves when they haven't had cancer themselves, but there's an opportunity to try and quantify whether or not they're at increased risk.  We know in families the uptake of those kinds of tests is different, and a lot of it is to do with timing and the way people respond to this in families might depend on their response to the cancer diagnosis in their relative, and of course what else is going on in their life at the time.  This aspect for the family is where clinical genetic services come in, because these initial tests in the person with blood cancer are done in their haematology/oncology setting, and normally the results about an inherited cause has been found are conveyed through that service.  That's when a referral to clinical genetics happens.  And in our specialist service we're addressing those additional concerns for the family which arise because of this diagnosis. Amanda: Thanks, Bev, for explaining that.  Sarah, coming back to you.  Could you tell me then if someone has an inherited blood cancer does it also change the way that the patient is treated? Sarah: Well, it certainly can do, and again, it does depend a little bit on the specific circumstances of that particular person and the form of inherited blood cancer predisposition that they have.  But certainly if we think about treatment as a whole, then for a lot of people it does affect the way that we might recommend treatments or look after them and their families.  So, for example, for some patients who have a diagnosis of an inherited form of blood cancer, we know that some treatments might be more or less effective for their particular set of circumstances.  And so that can sometimes influence the specific treatment recommendations that we would make, particularly thinking about, for example, the risks that the cancer might come back again after it's been treated.  Or thinking about whether or not some of the typical drug regimes that might be used might be perhaps more likely to cause them side effects or problems with tolerating that treatment.  So it can certainly make some changes in that respect. For some people, to be fair a minority of people with blood cancers, they may need a stem cell transplant as part of their treatment to hopefully cure them of their blood cancer.  And this as I say is a treatment that's required for a minority of patients as a whole who have a diagnosis of a blood cancer.  But for those people who have got an inherited predisposition and who might be recommended a stem cell transplant as part of their treatment, then knowing about a familial risk for this condition can also be really important.  For making sure that if a family member is being considered as a donor for example that we're being really careful to make sure that we're not choosing a donor that might also be affected by the same underlying blood cancer predisposition.  Because this can obviously cause problems for the person that's receiving the stem cells if it turns out that the person they're receiving them from actually has the same inherited condition as them.  So in that respect knowing about the underlying predisposition and genetic cause for their cancer can be helpful.  But in a more sort of general sense, yes, the other thing that it can have a big difference for is that some of these inherited cancer predispositions and syndromes also have other health conditions associated with them.  So it might be that that genetic diagnosis predisposes somebody not only to a form of blood cancer but to other health conditions as well.  And so actually knowing about that diagnosis can help their haematologist then make sure that they're linked in with the right other medical teams to make sure that those other health conditions are identified if they're present and taken care of.  And then I think really coming back to what Bev has already touched on, there's the sort of bigger picture of just how people are looked after in their own right but also as part of their family unit.  And making sure that they're given the right information and advice about their health, but also thinking about other family members.  And particularly for younger patients who perhaps either are just starting their own families or for whom that's not yet a consideration, making sure that they've got the information to understand what might be relevant for future family members, if that makes sense.  So it's not necessarily true to say that for every individual patient knowing that there's an inherited blood cancer present will necessarily directly affect the way that the treatment is offered.  But you can see that as a part of a bigger picture for a lot of patients, it will make a difference to their care as a whole.  Amanda: And you can really see how the impact is very sort of multigenerational and is going to affect people at all ages and stages of their life, so that's really interesting.  Katie, Bev spoke a little earlier about the fact that there are genetic tests that can help tell us if blood cancer is inherited.  Could you tell us more about what the tests involve, and some of your experience taking families through this?  Katie: There's sort of two main different ways that we might identify somebody has an inherited cause for their blood cancer through testing.  So traditionally what has happened, as Bev and Sarah sort of discussed before, is that when a person is diagnosed with a blood cancer, we either take a sample of their blood or bone marrow.  To try and look at what are the changes within those cells that have driven that cell to become a cancer cell and have driven this blood cancer to develop.  And a lot of the time, as we've said, it's not inherited, it's not genetic, so they're what we call acquired changes, they're changes that have just happened in the bone marrow or to the blood cells that have caused that kind of particular cell to become a cancer cell.  And it's really important that we look at those because that can help both diagnose the blood cancer, it can give us information about how serious that blood cancer might be, and it can also help us guide our treatments and therapies.  And so if we do those testings, they're primarily done within haematology for those sort of diagnostic or prognostic or treatment purposes.  We do sometimes see then a change that looks a bit suspicious that it might be inherited for various reason.  And if we see something that is in the cancer and it looks like there's a potential it could be inherited, we would go on and do a second test.  So usually because we can't do a blood test because the cancer's in the blood, we would take a skin biopsy.  And then we would look and see, well, is this change also present in the skin?  And if it is, then that indicates that that change is in all of the cells of the body, because it's in both the blood cancer and it's in the skin, and therefore it's likely to be inherited.  So that's one thing that we do.  And I think that that can be quite challenging for patients.  Because they go in to have a test for their blood cancer and then suddenly were being told, “Well, actually, we've also found something that might be inherited,” and it is something then that other members of the family might have.  And as Sarah said, potentially that means that even if your relative was offering to be a bone marrow donor for you, they might not be able to if they also carry the same thing.  And so that can be quite tricky just in terms of making sure that we're guiding the patient and their family members through that process.  And then thinking about the work that Genomics England does, particularly with whole genome sequencing, and this is particularly offered for children and young adults in the paediatric setting.  But I think we're also increasingly, as we progress we'll perhaps talk about this a bit, moving towards whole genome sequencing for adult blood cancers more routinely as well, that that is offered as a sort of standard of care.  And what whole genome sequencing is, is it is looking at the entire genetic instruction manual in both the blood cancer cells and in the cells that we're born with, to look at the inherited or germline genome as well.  And the reason that we look at both the cancer cells and the inherited or germline genome is because what we're trying to understand is firstly, are there any inherited changes that have led to the blood cancer developing?  But also, what are the changes that have just occurred in the cancer cells that are going to help us to diagnose and treat that blood cancer?  So by doing whole genome sequencing we get all of the information about all of the changes that might have happened, we know whether any are inherited, but importantly, we're certain of the ones that have just occurred in the cancer cells and can help guide us with their treatment.  And so, again, when we're talking to patients, we have to explain to them that we're going to be looking at their entire genetic information.  And what's interesting about that is it might find things that are not only relevant to blood cancer, but very rarely other findings, incidental findings as well, or we might find things that we don't know about.  But I think certainly that's something that patients often feel very comfortable with having because it gives them the maximum amount of information.  Amanda: Thanks, Katie.  So it really sounds like there's a lot of advancements that are being made in genetic technology which potentially brings a lot of new things for you and Bev as genetic specialists, but also for you, Sarah, as a haematology specialist.  What does that kind of change for you, and I assume it's really important then for you all to be working together as a multidisciplinary team?  Katie: Yes, I mean, I think for clinical genetics, we were not involved in sort of haematology pathways for a really long time, and the haematologists are absolute experts in the genomic factors that drive blood cancers.  And certainly in my practice, it's really only been as the technology advanced that we really started finding more and more of these inherited factors, particularly in the adult setting.  Because I think in the paediatric and childhood setting, the haematologists again have been managing those conditions very well for years.  And I think there's places that we really interface and we really need to work together as a multidisciplinary team, understanding the genetic information, really understanding when something that we've seen in the blood cancer or the bone marrow could be inherited.  Do we need to check that?  What should that pathway look like?  But I think as you've said, a lot of these are actually really quite new conditions, particularly in the adult setting.  And we don't yet 100% know why do some people get blood cancer and some people don't when they have the same inherited factor.  What's the actual risk?  Are there any other factors modifying it?  What makes some people progress to develop a blood cancer and some people not?  And for that we really need to work together to try and gather the data and sort of capture people that have these inherited changes.  And hopefully develop a system and an infrastructure that we can follow it long-term and get a lot of information about long-term outcomes, both for individuals with cancer but also their families.  And also from looking at doing population studies.  Because I think we know that lots of people in the general population might carry some of these inherited changes and never develop a blood cancer as a result of this, certainly ones that seem a bit lower risk.  So we really need to work together to understand all of that.  But I'd be really interested in Sarah's views on that as well.  Sarah: Yes, sure.  So I think, as you say, Katie, haematologists have got a long history of understanding and interpreting genetic findings in the sort of acquired or somatic changes that we know are what occurs in some blood cells to drive the cancer forming in the first place. But this kind of newer integration of that with the germline testing is something that is becoming much more mainstream in haematology now, and I think something that people have had to sort of acquire new skills in this area to interpret that alongside.  I think as you say, that multidisciplinary working, where we're able to benefit from both sides of our expertise and knowledge and put that together is so valuable, particularly in those circumstances where there is some uncertainty.  And I think as a haematologist, one of the things that I really find a benefit both personally and professionally to help me navigate these tricky questions but that I also think patients benefit from is your expertise and ability to have those really quite tricky conversations with people who are not haematology patients, if that makes sense.  So they may be the relatives of patients who have a haematological diagnosis for example.  Who at the moment are entirely well and were just going about their daily business, and they're now told that they may or may not potentially have this inherited predisposition.  And I think that as haematologists, we're very used to dealing with potentially quite poorly patients, potentially quite scared patients who find themselves, you know, the recipient of all this quite difficult information.  But we're not necessarily so skilled and experienced at holding conversations with people who don't yet have that diagnosis.  And I think that that's a really rich area of mutual aid to one another as haematologists and genetic doctors, if that makes sense.  And I think your points about understanding actually the real risks and the nature history, as we would call it, of what happens to people who carry these variants that predispose them to blood cancers is something that we can probably only work out by working together.  And of course, working with the patients and families that are affected by these conditions so that hopefully for both sides in the future we'll be able to give much better advice to patients and their families.  Amanda: So, Bev, from your experience and as a genetic counsellor, what do you feel are the important things that patients and their families should know as they're going through this testing and diagnosis process?  Bev: The things I think families where there is a hereditary cause found should know is that with this new information comes a whole new referral to a dedicated service.  Who want to help patients and their family members at risk to navigate this, to adjust the information, and to make decisions that fit with them, about whether to have testing and the timing of that.  As we already said, where there is a hereditary blood cancer risk, that risk in family members is rarely 100%.  Depending on what the hereditary predisposition is in the family, we may be able to quantify that risk, sometimes we can't always.  And the other thing to know which links to that is that there is growing interest in research in this area.  That will really help us to improve care in terms of, for example, being able to quantify the risk of developing a blood cancer in relatives who are perfectly well that may have inherited these predisposition gene changes.  Or, for example, the other obvious place where we want to make improvements in terms of some sort of evidence-based surveillance for those people who want to find out that they have inherited the genetic change and are at increased risk.  Amanda: Thank you.  And overall there's been a lot I think we've been covering today that's probably going to be very new to many people.  Why do you think it's important to raise public awareness of inherited blood cancers?  Bev: There have been lots of public awareness campaigns about other cancers, as listeners probably can think about, in terms of for women checking their breasts and breast cancer awareness.  And perhaps there's been a bit less of that in general for blood cancers.  As we've already talked about, clinical genetics were not so involved in all of the genetic testing happening in blood cancers.  Because it wasn't so long ago in the history of how we think about inherited cancers in general that our suspicion of inherited causes in leukaemia was much lower than it is now.  So I think that awareness in the public probably will take a bit more effort to bring up.  But clearly public awareness about blood cancers in general, symptom awareness, and the fact that occasionally it can be something that is running in the family, clearly better public awareness of that means that people are empowered to ask the right questions.  And the questions that might already be in some way going through their minds of their haematology doctors or perhaps of their GP, if they've got a family history but are not affected themselves.  Amanda: Wonderful.  So, looking now to the future, Katie, what genomic advancements are we seeing or are we likely to see that could impact on the care of people with an increased genetic risk of blood cancer?  Katie: We touched a little bit, I think that whole genome sequencing is expanding.  And as we can turn that test around and get it back more quickly that might become more commonplace.  And I know Genomics England and the UK Haemato-oncology Network of Excellence have been doing a lot of work in that area.  We are very lucky now we have a national inherited cancer predisposition register that NHS England have set up with the National Disease Registration Service.  So that will enable us to capture individuals that have these sort of rarer but single gene disorders or conditions that increase the chance of developing blood cancers.  And that will enable us to do that sort of longer-term follow-up and get really more information.  We've touched on this already but I think there's really amazing research happening, why do some people develop blood cancers and some people don't, even though everyone carries the same underlying change that increases the risk?  And then I think really importantly, we're seeing now in some conditions, clinical trials of certain medications to see if that can actually prevent people who carry these inherited changes from progressing to developing blood cancers.  So I think all of those things are really exciting and will give us lots more information that we can then help patients and their families, particularly the sort of treatment and trials aspects.  Amanda: And, Sarah, on treatment and trials, how do think genomics might improve the treatment, but also the diagnosis of people with inherited blood cancers in the future?  Sarah: I think, you know, hopefully when we are able to accrue more information about these underlying genetic predispositions and how they actually then affect people's likelihood of developing blood cancer, we'll be able to build on what we have so far to make that just feel much more robust and evidence based.  And it feels like at the moment there are many of us struggling to bring together small threads of evidence that have been accrued in the UK but in other centres around the world that are also interested in understanding this inherited blood cancer risk.  In such a way that we can actually give patients and their families more clear information and advice about what that means to them.  And I think that in terms of the diagnosis of blood cancer, I think this is something that Bev alluded to.  If we could better understand who might benefit for example from having regular screening or monitoring blood tests performed to see whether we can detect an emerging blood cancer.  Versus identifying those people who actually, the chances of them developing a blood cancer are so small that doing those tests is likely to do them more harm than good.  Perhaps by just causing them to be anxious or have other sort of unintended consequences of that kind of testing.  So understanding something more about that natural history, as we've already alluded to, will hopefully improve our ability to go from the diagnosis of the predisposition condition to working out how to then diagnose the blood cancer on the back of that.  And with time, I think as Katie has alluded to, thinking about more specific treatments and more tailored treatments to the individual predisposition condition and the blood cancer.  So whether it's that you're intervening before the blood cancer has developed to try and reduce that happening, or whether it's that you're then treating the blood cancer after it's developed.  Understanding the genetic basis and what it is that causes that transition would be really helpful and I think that is something that will come but will take time.  And I think on a sort of national level what I would really hope to see over time is that we're able to use that improvement in evidence base to then be able to bring together perhaps more defined patient pathways.  So that if you're diagnosed with a particular condition, one of these leukaemia predisposition syndromes or another form of blood cancer predisposition, there's a recognised strategy and set of steps that should be taken for all of those patients.  To make sure that they're getting equity of care and make sure that everything is being done in a way that feels safe, sensible and appropriate across the country.  While still then enabling us to give really personalised treatment to that individual person and what that diagnosis means for them.  But I think until we've gathered more information and more evidence we are just in the process of trying to do that to then bring about those changes.   Amanda: If you enjoyed today's episode, we'd love your support.  So please subscribe, share and rate us on wherever you listen to your podcasts.  I've been your host, Amanda Pichini.  This podcast was produced by Deanna Barac and edited by Bill Griffin at Ventoux Digital.  Thank you for listening. 

A few months ago, we discussed three films about the press speaking truth to power. What happens when the powerful pervert media for profits? As it enters The Criterion Collection this week, Sidney Lumet's satirical look at television news- 1976's "Network"- feels like a documentary of the times we live in now. Joining me to discuss the legacy of this film is Jason from Binge Movies and The Slashers and Joan Amenn from In Their Own League. I hope you enjoy!

Today's Headlines: Tonight is Donald Trump's State Of The Union. Dozens of Democrats are skipping, and there will be three official rebuttals: Gov. Abigail Spanberger (main), Sen. Alex Padilla (Spanish-language), and Rep. Summer Lee (progressive). In Mexico, the head of the Jalisco New Generation Cartel was killed in a military operation aided by the US. The cartel is responding by torching buses and businesses and clashing with security forces.. Some U.S. flights to Puerto Vallarta and Guadalajara were suspended, and the State Department activated a 24/7 hotline for stranded Americans. Judge Aileen Cannon blocked release of part of Special Counsel Jack Smith's report on Trump's handling of classified documents at Mar-a-Lago, citing “manifest injustice” to Trump. In other news, Trump envoy Paolo Zampolli is pushing for Russia's return to global competitions despite Ukraine war–related bans. A Russian team will compete at next month's Paralympics, prompting backlash and a Ukrainian boycott of the opening ceremony. In the UK, former ambassador Peter Mandelson was arrested on suspicion of misconduct in office over alleged information-sharing with Jeffrey Epstein. A Politico-reported analysis found 18,000+ bots amplified Nicki Minaj's recent pro–White House posts, especially when labeled toxic.  Finally, a PRRI survey found about one-third of Americans are sympathetic to Christian nationalism, while 54% call Trump a “dangerous dictator” and 42% see him as a “strong leader.” and Providence, Rhode Island just set a single-storm snowfall record at 33 inches, beating 1978.  Resources/Articles mentioned in this episode: Axios: Democratic response to Trump's SOTU becomes a crowded affair  CNN: US citizens in parts of Mexico urged to still shelter in place as nation on edge following drug lord's killing  MS Now: Judge Cannon blocks release of Jack Smith's classified documents report NYT: Trump Official Backs Russia's Return to Global Sports  BBC: Lord Mandelson arrested on suspicion of misconduct in public office Politico” Nicki Minaj's social media propped up by thousands of bots, analysis finds USA Today: Is or should America be a Christian nation? One-third say 'yes'  NYT: Monday's Snowfall Shatters a Record in Rhode Island  Subscribe to the Betches News Room and join the Morning Announcements group chat. Go to: ⁠⁠⁠betchesnews.substack.com Morning Announcements is produced by Sami Sage and edited by Grace Hernandez-Johnson Learn more about your ad choices. Visit megaphone.fm/adchoices

Another day, another malicious JPEG https://isc.sans.edu/diary/Another%20day%2C%20another%20malicious%20JPEG/32738 Calibre Path Traversal Leading to Arbitrary File Write and Potentially Code Execution CVE-2026-26064 CVE-2026-26065 https://github.com/kovidgoyal/calibre/security/advisories/GHSA-72ch-3hqc-pgmp https://github.com/kovidgoyal/calibre/security/advisories/GHSA-vmfh-7mr7-pp2w CVE-2026-25755: PDF Object Injection in jsPDF (addJS Method) https://github.com/ZeroXJacks/CVEs/blob/main/2026/CVE-2026-25755.md Roundcube Webmail Exploited CVE-2025-49113 https://roundcube.net/news/2025/06/01/security-updates-1.6.11-and-1.5.10 https://www.openwall.com/lists/oss-security/2025/06/02/3

Join Ben Fraser as he talks with Seth Bradley, Esq., Chief Legal Officer at Tribevest, about an opportunity hiding in plain sight: turning your network into a fund of funds.In this episode, you'll learn:• How the fund-of-funds model works and why it's gaining momentum• How professionals are leveraging their networks to raise capital• The steps to start your own fund of funds, the compliant wayIf you've ever wondered how to go from investor to fund manager, this episode breaks it down step by step.Have more questions, or want more resources like a tax calculator? Go to ⁠⁠⁠⁠https://investlikeabillionaire.org/⁠⁠⁠⁠  to learn more about our community. Check out Ben & Bob's company and invest along at ⁠⁠⁠⁠https://aspenfunds.us/

Oftentimes, people look at networking groups as just a bunch of leads they need to convert or people to get referrals from. How about you? Do you see the value of joining a group or a forum? In this fan favorite replay episode, let's talk about the greater reason why you should join networking groups: for learning. Many of us didn't go into entrepreneurship armed with degrees in business, marketing or management. Discover how being in a community of like-minded professionals brings us so much more than merely a place to promote our business.    Show notes available at www.leadinglady-coaching.com/podcast   Resources Mentioned:  Have you joined the Leading Ladies Facebook Group yet?! I would love to see you in there! Head to https://www.facebook.com/groups/LeadingLadiesAAL to join! Let's connect on Facebook: https://www.facebook.com/aalcoaching Let's connect on Instagram: https://www.instagram.com/leading.lady.coach/

A new investigation reported that convicted sex offender Jeffrey Epstein covertly rented at least six storage units across the United States from as early as 2003 up until his death in 2019, allegedly using them to stash computers, CDs, photographs, and other materials linked to his homes and his private island Little Saint James. Financial records and emails reviewed by The Telegraph indicate Epstein paid private investigators tens of thousands of dollars to move equipment from his properties into these units ahead of police raids, raising the possibility that law enforcement never searched them and that they may still contain never-before-seen evidence connected to his sex trafficking network.Some of the emails suggest private detectives copied or “cloned” data from drives before storing them, and in one instance discussed holding potentially responsive computer materials requested by attorneys for a survivor of Epstein's abuse. Other correspondence shows Epstein instructed aides to transfer items out of his Florida home when tipped off about impending warrants, and discussed the location of storage contents even while incarcerated in 2009. Because these external storage lockers appear never to have been searched by authorities, there is concern among journalists and investigators that crucial evidence – including digital files predating the trove released by the Department of Justice – could still be hidden from public view.to contact me:bobbycapucci@protonmail.comsource:Jeffrey Epstein stashed secret files in storage units across US that may include unseen evidence: report

If you're serious about networking, sooner or later you'll meet someone who isn't playing by the same rules—someone who takes but doesn't give. So what do you do when that happens? For more great insight on professional relationships and business networking contact Frank Agin at frankagin@amspirit.com.

Chancellor Johnson of the Big 12 Network joins 365 Sports to break down Houston's recent three game skid and what it means for the Cougars' Final Four aspirations as the regular season winds down. Johnson discusses how Kansas continues to find ways to win under Bill Self, the impact of injuries on Texas Tech and BYU heading into March, and why the nightly grind of the Big 12 may be the best preparation for a deep NCAA Tournament run. Plus, which teams are built to survive the conference gauntlet, who could make a surprise push in the Big 12 Tournament, and how the league's depth could shape the March Madness bracket. #big12 #big12mbb #marchmadness #rockchalk Learn more about your ad choices. Visit megaphone.fm/adchoices

Attention Goal Getters! Have you ever done a day-by-day review of your calendar to help you set goals for your future? Executive Coach Michael Melcher recommends using the "lookback method" to determine what's important for you in the new year. Instead of making a list of resolutions from what is top of mind, Michael recommends going through your calendar and reflecting on your wins for the prior year. Find out what gives you energy, joy and purpose and do more of it!An expert on building and cultivating relationships, Melcher also shares his suggestions for building a professional network that will transform your career.

When we have trauma, it may feel harder for us to “see.” Our intention allows our intuition to perceive what our physical senses may not.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Mother Nature is not done with the U.S. this winter; Kevin talks about the U.S. Olympic Hockey Team's magic moment against the heavily favored Canadian Team and recalling the 1980 "Miracle on Ice" vs the Soviet Union; the Supreme Court issues it's ruling  on Trump's tariffs; Kevin has the details, puts the information into historical perspective, offers his insights and opinions.

Halftime! Super Bowl 60 was held on February 8, featuring a halftime show by Latin superstar Bad Bunny (with special guests Lady Gaga and Ricky Martin), and a pre-game performance by neo-punks Green Day. But in reaction against this, there was a second, independant “All American” halftime show featuring Kid Rock, Gabby Barrett, Lee Brice, and Brantley Gilbert. Both shows had their controversies […] The post Modern Musicology #160 – Halftime! appeared first on The ESO Network.

Episode 46: Showgirls VS Alien This week, we dove headfirst into the neon chaos of Showgirls. Leah had seen it years ago. Shawn had not. We pressed play with cautious optimism. That optimism did not survive. The acting feels loud, awkward, and strangely theatrical. The story wanders. Characters make choices that defy logic. And yes, […] The post Showgirls VS Alien appeared first on The ESO Network.

SUBSCRIBE AND SHARE WITH A SISTER FRIEND IN THIS EPISODE I'M SHARING ON: To meet your husband through your network To start using your connections to be visible to your husband Inside Wife In Waiting you'll learn the exact steps to be visible to your husband through your network Even if you don't know where to start or how to leverage your current network to make it happen Wife In Waiting is designed for Christian single women over 30 who are ready to get into the right relationship in 6 months and married in a year Doors are open until February 28 When you apply by tonight you also have access to 1-1 coaching with me on WhatsApp for 1 week APPLY HERE FOR WIFE IN WAITING: https://bit.ly/datelikeawifereview

Randi and Sarah discuss ELNoST, or the Expanded Learning Network of the Southern Tier. It's a group of agencies working together throughout the region on educational policy, advocacy, and best practices for children ages 8-18. And don't forget our newest segment as Randi and Sarah spill more nonprofit tea!

I have known so many great people who have not just made a difference in the industry, but a difference in my life, and Gavin Young from Vodafone is no exception. In this episode, we discuss a holistic view of technology, the era of smart CPE and smart networks, and how operators face an exhausting goal of ensuring things “just work” for everyone, all the time.

Melissa A. Washington joins the VET S.O.S. Network to dive into how connection, visibility, and purpose shape life after military service for women veterans. A Navy veteran and founder of Women Veterans Alliance, Melissa shares powerful insights on navigating transition, building resilient communities, and creating a legacy of impact.In this episode, we explore:• Why women veterans need community-driven connection• How visibility creates leadership and opportunity• Resilience, vulnerability, and evolving purpose after serviceWhether you're navigating military transition, growing a business, leading a nonprofit, or redefining service beyond the uniform, this episode offers practical guidance and inspiration.Melissa A. Washington is a U.S. Navy veteran, entrepreneur, and nationally recognized advocate for women veterans. As founder of Women Veterans Alliance, she has helped elevate thousands of women veteran leaders and business owners worldwide.The VET S.O.S. Network connects veterans, service members, and military spouses with real resources and real people who want to see you thrive.• VET S.O.S. • VET S.O.S. — Operation Startup• VET S.O.S. — Learning LifelineWebsite: vetsospodcast.comX/Twitter: @vetsospodcastLinkedIn: linkedin.com/company/vetsospodcastYouTube: youtube.com/@vetsospodcastFacebook: facebook.com/vetsospodcastInstagram: instagram.com/vetsospodcastTikTok: tiktok.com/@vetsospodcast#WomenVeterans #VeteranTransition #VeteranLeadership #MilitaryCommunity #VeteranSupport #VETSOS #TheMilitaryEffect #WomenWhoServe #PurposeAfterService #GrabTheLifeline

Podcast: PrOTect It All (LS 27 · TOP 10% what is this?)Episode: Compliance Isn't Security: NERC CIP 15 and the Real Gaps in OT Network MonitoringPub date: 2026-02-23Get Podcast Transcript →powered by Listen411 - fast audio-to-text and summarizationPassing an audit doesn't mean you're secure. In this episode of Protect It All, host Aaron Crow dives into one of the biggest misconceptions in operational technology: the belief that compliance equals protection. Using NERC CIP 15 as a real-world case study, Aaron explores why meeting regulatory requirements is only the starting point - not the finish line. A major focus of this conversation is OT network monitoring, especially the often-overlooked east-west traffic inside your environment. Many organizations monitor perimeter traffic while internal blind spots remain wide open. You'll learn: Why compliance frameworks don't automatically create security The real challenges of implementing NERC CIP 15 at scale Why internal network visibility (east-west monitoring) matters How to establish meaningful baselines in legacy OT environments The difference between audit success and operational resilience Why architecture, tooling, and skilled personnel must work together Whether you're working in utilities, manufacturing, or critical infrastructure, this episode provides practical guidance on how to move beyond checklists and build security programs that truly reduce risk. Tune in to learn how to transform compliance requirements into real operational protection - only on Protect It All. Key Moments:  00:00 OT Security Blind Spots 05:15 "OT Security and Monitoring Challenges" 10:41 Aging Switches and Monitoring Challenges 13:16 OT Protocols and Infrastructure Challenges 15:42 "IT vs OT: Complexity Challenges" 18:03 "Balancing Compliance and Security" 21:57 Securing Critical Infrastructure Spaces Connect With Aaron Crow: Website: www.corvosec.com  LinkedIn: https://www.linkedin.com/in/aaronccrow Learn more about PrOTect IT All: Email: info@protectitall.co  Website: https://protectitall.co/  X: https://twitter.com/protectitall  YouTube: https://www.youtube.com/@PrOTectITAll  FaceBook:  https://facebook.com/protectitallpodcast   To be a guest or suggest a guest/episode, please email us at info@protectitall.co Please leave us a review on Apple/Spotify Podcasts: Apple   - https://podcasts.apple.com/us/podcast/protect-it-all/id1727211124 Spotify - https://open.spotify.com/show/1Vvi0euj3rE8xObK0yvYi4The podcast and artwork embedded on this page are from Aaron Crow, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.

A new investigation reported that convicted sex offender Jeffrey Epstein covertly rented at least six storage units across the United States from as early as 2003 up until his death in 2019, allegedly using them to stash computers, CDs, photographs, and other materials linked to his homes and his private island Little Saint James. Financial records and emails reviewed by The Telegraph indicate Epstein paid private investigators tens of thousands of dollars to move equipment from his properties into these units ahead of police raids, raising the possibility that law enforcement never searched them and that they may still contain never-before-seen evidence connected to his sex trafficking network.Some of the emails suggest private detectives copied or “cloned” data from drives before storing them, and in one instance discussed holding potentially responsive computer materials requested by attorneys for a survivor of Epstein's abuse. Other correspondence shows Epstein instructed aides to transfer items out of his Florida home when tipped off about impending warrants, and discussed the location of storage contents even while incarcerated in 2009. Because these external storage lockers appear never to have been searched by authorities, there is concern among journalists and investigators that crucial evidence – including digital files predating the trove released by the Department of Justice – could still be hidden from public view.to contact me:bobbycapucci@protonmail.comsource:Jeffrey Epstein stashed secret files in storage units across US that may include unseen evidence: reportBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-moscow-murders-and-more--5852883/support.

Godfrey and the crew kick things off reacting to a fan-made opening before diving into a raw, wide-ranging conversation about success, legacy, celebrity politics, and the dangers of performative leadership. The episode takes a sharp turn into Stephen A. Smith's political commentary, tokenism, and why certain voices are elevated while others are ignored. From Nicki Minaj controversy to Black accountability, media narratives, and uncomfortable truths about power and perception, this one goes everywhere.Beat Contest Winner: taconetheartist@gmail.comSend a nice email if you're a fan. We have tons of artists that are fans of this podcast so if you're looking to make new music, lease a beat,collab, love to hear yoir future tracks Guests: Yamaneika Saunder and Akeem Woods

Please join Denise and Samantha as they continue the conversation with Part 2 of the Intuition Lab! In our last episode we talked about the default mode network in creativity and intuition, the importance of daydreaming, and the benefits of meditation and mindfulness practices. In this episode, we take it a step further and explore the salience network, which is the filtering system your brain uses to detect the subtle cues and signs your conscious mind might miss. The discussion also includes ways to train and activate the salience network through mindfulness, body awareness, sensory scans and creative activities. There is so much more in this episode, please tune and learn ways to connect more fully with your own salience network! If you would like more information about Samantha and her offerings, please visit: http://samanthafey.com Denise and her services are at: http://thegratefulmessenger.com

Japanese-Language Phishing Emails https://isc.sans.edu/diary/Japanese-Language%20Phishing%20Emails/32734 'God-Like' Attack Machines: AI Agents Ignore Security Policies https://www.darkreading.com/application-security/ai-agents-ignore-security-policies Starkiller: New Phishing Framework Proxies Real Login Pages to Bypass MFA https://abnormal.ai/blog/starkiller-phishing-kit

Stalwart 3rd mic Mike brings his friend, combat sports and toy legend Jason Mayhem Miller to a show in which he doesn't understand but rocks with. We get into his (wifes) toy company in LA, The Costa Rica Labubu situation, why Stanley might be a sleeper agent, modern Seinfeld, DeentheGreat getting beat up at Rampage Jackson's house, we give a history leeson, and everything is Epstein.Air Date 2/19/26DON'T FORGET TO WATCH FAGA'S NEW SPECIAL "BURN AFTER SAYING" ON THE HSR YOUTUBE PAGE!⁠⁠https://www.youtube.com/watch?v=TxIHJU2LotU⁠⁠Support Our Sponsors!Body Brain Coffee: https://bodybraincoffee.com/ - Grab A Bag of Body Brain Coffee with Promo Code HSR20 to get 20% off!YoKratom - https://yokratom.comHigh Society Radio is 2 native New Yorkers who started from the bottom and didn't raise up much. That's not the point, if you enjoy a sideways view on technology, current events, or just an in depth analysis of action movies from 2006 this is the show for you.Chris Stanley is the on air producer for Bennington on Sirius XM.Chris Faga is a lifelong street urchin, a former head chef, county comitteman and supposed comedian. Twitter: https://twitter.com/ChrisFromBklynInstagram: https://www.instagram.com/chrisfrombklynEngineer: DomExecutive Producer: JorgeInstagram: https://www.instagram.com/themharrington/Twitter: https://twitter.com/TheMHarringtonSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

It feels like ICE agents are everywhere, conducting “snatch and grabs” off the street, raiding small businesses like restaurants, and intercepting people at their jobs, schools, and court proceedings. Host Megan Harris is with the founder of Frontline Dignity, Jaime Martinez, to talk about what's going on in Pittsburgh right now, what happens when someone is taken, and their odds of coming home. Martinez also shares a condensed version of Frontline Dignity's popular rapid response training, where hundreds of Pittsburghers have learned how to spot ICE, what questions to ask, and who to call for help. Want to join Frontline Dignity's growing network? Attend a training first! They fill up quickly, but you can be the first to know about them and federal enforcement operations by following Frontline Dignity on Instagram. Learn more about the sponsors of this February 23rd episode: The Frick Pittsburgh P3R Pittsburgh Opera Living Memory Become a member of City Cast Pittsburgh at membership.citycast.fm. Want more Pittsburgh news?  Sign up for our daily morning newsletter. We're on Instagram @CityCastPgh. Text or leave us a voicemail at 412-212-8893. Interested in advertising with City Cast? Find more info here. 

Send a textDoug is back from his new “usual”, Brisbane, Australia, and Drew discusses an ATC flow program as they transition from paper to electronic flight progress strips. Paper to Electronic ATC flight progress stripsNew routes for FebruaryLufthansa Allegris business class seats Will Airbus launch the A350-2000?Canadians avoiding travel to the USLas Vegas Slump? Join the Network! https://www.nexttripnetwork.com/

This episode concludes the coverage of the UKC Winter Classic in Batesville, Mississippi.  Complete event coverage may be found on social media on the UKC Coonhound pages. Steve and Nubbin spent five days on the enjoyable annual trip including great rustic lodging and phenomenal food.   The Winter Classic is a coonhound event Steve founded in 1988 when he was with United Kennel Club, and attracts coon hunters and their families from across the nation to Batesville each February.  We would like to thank those who support this podcast.  Special thanks to Double U Hunting Supply for sponsoring this episode.   www.dusupply.com https://www.youtube.com/@DoubleUHuntingSupply/podcasts Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, I sit down with Kenneth Shek from Animoca during Consensus Week in Hong Kong.We talk about what it really takes to drive mass adoption in Web3. Not hype. Not narratives. Real users.Kenneth shares how Moca Network is building the identity layer for the future of programmable money. We go deep into AI-native infrastructure, stablecoins, loyalty systems, and why distribution is the real moat.We also discuss why most Web3 projects struggle with adoption, what Web2 got right, and how AI agents will reshape commerce by 2026.If you care about identity, payments, AI, or building the next killer app in crypto, this episode is for you.Key LearningsKenneth's journey from startups, AI, and Accenture to AnimocaWhy identity is the missing layer for stablecoins and AI agentsWhy blockchain hasn't hit mass adoption yetThe biggest lesson from talking to enterprise customersAIR: Account, Identity, Reputation explainedWhy one-click UX matters more than decentralizationAI agents replacing front-ends and changing product designRegulatory fragmentation and global crypto challengesWhy distribution beats building another “killer app”Stablecoins, RWA, and the future of programmable loansIf starting today: build AI-agent native from day oneHiring engineers, fintech builders & strategic partnersConnect with Mocahttps://moca.network/enhttps://x.com/Moca_Networkhttps://t.me/MocaverseCommunityhttps://www.linkedin.com/in/ks20/ DisclaimerNothing mentioned in this podcast is investment advice and please do your own research.It would mean a lot if you can leave a review of this podcast on Apple Podcasts or Spotify and share this podcast with a friend.Be a guest on the podcast or contact us - https://www.web3pod.xyz/