POPULARITY
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.22.517223v1?rss=1 Authors: Calla, J., Mittal, N., LaMonte, G., Liffner, B., Godinez-Macias, K., Carolino, K., Walker, G. T., Zou, B. Y., Paytas, E., Guerra, L., Tong-Rios, C., Campo, B., Vinetz, J. M., Gamboa, D., Raffatellu, M., Absalon, S., Winzeler, E. Abstract: Changes in host cell morphology and transcription after apicomplexan parasite infection have long been noted, but there have been few studies of the functional consequences of host cell remodeling. Here we show, using time-dependent immunofluorescence microscopy of multiple human cell lines (HFF, HepG2, HC-04, Huh7.5.1 and primary human hepatocytes), infected with multiple Plasmodium species (Plasmodium berghei, P. falciparum and P. vivax (hypnozoites and schizonts)), and antibodies to multiple human proteins (HsNR4A3, HsMUC13, HsGOLGA8A, HsCGA, HsBiP, HsCXCL2), that human protein trafficking is extensively modified in Plasmodium infected cells. Using conventional as well as ultrastructure expansion immunofluorescence microscopy we show that newly-synthesized human proteins are trafficked to the parasitophorous vacuole instead of the infected-cell plasma membrane, nucleus or extracellular space. Universal redirection of human signaling proteins cells the parasitophorous vacuole may provide a mechanistic explanation for how apicomplexan parasites can block host cells response to infection. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence viaa multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the humanhost populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35845]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Infectious diseases have profound influences on the evolution of their host populations. In the case of humans, the host species has also shaped pathogen dynamics and virulence via a multitude of factors from changes in social organization, group size, and exploitation of varied habitats and their animals and plant resources to agriculture, technology, rapid long-distance travel, medicine and global economic integration - which all continue to shape epidemics and the human host populations. This symposium will explore how infectious agents and humans have shaped each other over the eons. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36037]