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Latest episodes from Health and Medicine (Video)

Circadian Rhythm and Intermittent Fasting for Healthy Lifespan - LEE Tuh-Fuh and Ruby LEE Wang Zu-Ming Endowed Lecture

Play Episode Listen Later Nov 7, 2025 87:52


Circadian timing shapes how we sleep, feel, and function each day. Satchidananda Panda, Ph.D., Salk Institute, explains that keeping daily light, meals, movement, and sleep in step with the body's internal clock supports alertness, metabolism, and recovery. Panda notes that evening light and late eating can make it harder to fall asleep and may work against healthy glucose control, while thoughtful timing of activity can improve energy and rest. He highlights that when we take medicines matters because the body's response changes across the day. Travel and shift work challenge these rhythms, but simple habits with light exposure, meal timing, and sleep can ease the strain. Panda also describes ongoing efforts testing practical routines, including limited daily eating windows paired with light and activity strategies. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40733]

Why Resilience Matters

Play Episode Listen Later Nov 1, 2025 9:21


Danielle K. Glorioso, LCSW, examines resilience as a skill that can be strengthened. Glorioso explores the many health benefits of resilient behavior. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41123]

Mobile Mental Health for Students: Triton CORE

Play Episode Listen Later Oct 31, 2025 17:03


Campus-based mental health response matters everywhere, providing timely help that prevents crises and keeps students thriving. At UC San Diego, Triton CORE's mobile, trauma-informed clinicians meet students where they feel safest and connect them to least restrictive care. Series: "Education Channel" [Health and Medicine] [Education] [Show ID: 40955]

mental health students mobile campus triton series education channel health
UCSF Fresno at 50: Advancing Health in the Central Valley

Play Episode Listen Later Oct 29, 2025 4:56


Founded in 1975, UCSF Fresno commemorates 50 remarkable years of training local doctors and improving healthcare in California's Central Valley in 2025. UCSF Fresno is a regional campus of UCSF's School of Medicine, located in the heart of California's San Joaquin Valley. By both serving and drawing strength from extraordinarily deep community roots, UCSF Fresno brings critical health care to families while to growing the next generation of health care providers and researchers. [Health and Medicine] [Show ID: 40987]

Mental Health and Resilience

Play Episode Listen Later Oct 24, 2025 42:37


Psychological resilience in later life examines how older adults adapt after adversity and cultivate everyday practices that sustain well-being and purpose.Elizabeth W. Twamley, Ph.D., introduces and guides a discussion on mental health and resilience among older adults. Ellen E. Lee, M.D., characterizes resilience as dynamic learning oriented toward flourishing and urges a low threshold for seeking help when symptoms overwhelm daily routines. Sidney Zisook, M.D., presents grief as adaptation to loss, distinguishes acute from integrated grief, and explains how intense waves of emotion gradually become less frequent and more manageable; he views psychedelic therapies as promising but not ready for routine treatment. Marti E. Kranzberg shares practical approaches that include mindfulness, journaling, gratitude, movement, sleep, pain management, creative arts, time in nature, community, and purpose. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40963]

The Grieving Process and Tips to Help

Play Episode Listen Later Oct 21, 2025 8:11


Danielle K. Glorioso, LCSW, explores the complex nature of grief, emphasizing that it is a lifelong, evolving response to loss rather than something to “get over.” She explains the differences between acute grief, integrated grief, and prolonged grief disorder. Drawing on both professional expertise and personal loss, Glorioso offers practical strategies for coping, supporting others, and finding hope while honoring the memory of loved ones. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41121]

Cognitive Health and Resilience

Play Episode Listen Later Oct 18, 2025 44:16


Cognitive resilience grows from small, consistent habits that keep the brain adaptable. Fadel Zeidan, Ph.D., frames mindfulness as mental training that improves attention, processing, and the way people relate to pain. Erin E. Sundermann, Ph.D., underscores modifiable pathways to healthier aging, highlighting movement, social connection, hearing support, and lifelong learning as mutually reinforcing drivers of brain health. Raenne C. Moore, Ph.D., centers practical strategies that translate into daily life, including routines, planned breaks, reducing distractions, and attending to anxiety or depression. Carolyn Dunmore, an older adult community Mmmber, exemplifies resilience through steady activity, purposeful community roles, faith, self-compassion, and the “use it or lose it” mindset. Together, Zeidan, Sundermann, Moore, and Dunmore point to a clear theme: everyday practices accumulate to support memory, attention, and well-being as people age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40962]

Stem Cells for Conservation: Trials and Tribulations of a Non-Model System

Play Episode Listen Later Oct 17, 2025 64:46


Marisa Korody, Ph.D., leads groundbreaking work at the San Diego Zoo Wildlife Alliance's Beckman Center for Conservation Research, where scientists use advanced genetic and stem cell technologies to protect endangered species. Korody highlights efforts to save the critically endangered northern white rhino by developing induced pluripotent stem cells that can be transformed into egg and sperm precursors, offering a potential path to revive the species. This research is part of a broader conservation mission that includes global projects in genetics, reintroduction, and community engagement. By combining cutting-edge science with wildlife management, the San Diego Zoo Wildlife Alliance works to preserve biodiversity and ensure the survival of species threatened by habitat loss, poaching, and climate change, demonstrating the critical role of innovation in conservation. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40451]

Translational Geroscience: Using Aging Research to Improve Resilience in Older Adults

Play Episode Listen Later Oct 15, 2025 48:00


Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Stem Cells and Precision Regenerative Medicine in Breast Cancer - Medicine Informing Novel Discoveries (MIND)

Play Episode Listen Later Oct 11, 2025 67:39


Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Physical Health and Resilience

Play Episode Listen Later Oct 10, 2025 49:42


Healthy aging starts with physical resilience, the body's ability to withstand and recover from stress. Maile Young Karris, M.D., defines the concept and sets the stage for practical strategies that match real-world needs. Ryan J. Moran, M.D., M.P.H., recommends simple routines such as wall push ups, posture alignment, and chin tucks, and he links posture and vision to fall prevention; social connection helps people stick with movement. Theodore Chan, M.D., F.A.C.E.P., F.A.A.E.M., explains that age alone is a poor predictor of outcomes in acute care and that functional resilience strongly influences decisions. Gail Levine emphasizes accountability, community, and balanced nutrition. Moran highlights protein needs of about 1 to 1.2 grams per kilogram plus calcium with possible vitamin D, and he favors plant focused eating with limited processed foods. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40960]

New Treatments for Advanced Prostate Cancer

Play Episode Listen Later Oct 6, 2025 9:39


Dr. Rahul Aggarwal presents emerging treatments for advanced prostate cancer, highlighting rapid advances in drug development. He outlines therapies targeting cancer cell surface proteins beyond PSMA, including CD46, B7-H3, and DLL3, and explains how antibody-drug conjugates deliver potent chemotherapy directly to tumors. He also discusses bispecific T-cell engagers designed to trigger immune attacks on cancer cells, including promising results from agents like Talquetamab. Aggarwal explores new isotopes such as actinium-225 for radioligand therapy, which may offer stronger and more durable responses than current treatments. He emphasizes continued innovation in targeting the androgen receptor, with drugs that degrade the receptor or block androgen production more effectively than existing therapies. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40813]

The Science of Bouncing Back: How Resilience Changes Across the Lifespan

Play Episode Listen Later Oct 3, 2025 47:41


Heather E. Whitson, MD, MHS explores how resilience—the ability to recover and adapt after stress or illness—changes across the lifespan. She explains that bounce back slows with age and that people age at different rates, influenced by biology, lifestyle, and environment. Studies connect lower inflammation, stronger cellular health, and emotional well-being to better recovery, such as regaining mobility after hip fracture or coping with persistent pain. Whitson also highlights how changes in the brain, like the buildup of amyloid and tau proteins, begin years before memory problems, underscoring the importance of early prevention. She points to practical steps that support resilience at any age: staying active, eating a Mediterranean style diet, managing blood pressure and blood sugar, protecting vision, engaging socially and mentally, prioritizing sleep, avoiding harmful exposures, and preventing injuries. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40959]

Targeting the MLL Complex in Leukemia

Play Episode Listen Later Oct 1, 2025 58:44


Scott A. Armstrong, M.D., Ph.D., of the Dana-Farber Cancer Institute, studies how certain aggressive forms of acute myeloid leukemia (AML) develop and survive. His work centers on a protein called menin, which helps leukemia cells keep cancer-promoting genes switched on. Armstrong's team has found that blocking menin with specially designed drugs can shut down these gene programs, push leukemia cells to mature, and slow or stop the disease in lab models and patients. While some leukemias adapt by developing mutations in menin or finding other ways to survive, his research is revealing why certain genes are especially dependent on menin and how to target them more effectively. These discoveries are now shaping new treatments, drug combinations, and potential strategies for other cancers that rely on similar mechanisms. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40875]

Navigating Grief: What the Science of Resilience Teaches about Adaptation to Loss

Play Episode Listen Later Sep 26, 2025 69:20


Danielle K. Glorioso, LCSW, explores the complex nature of grief, emphasizing that it is a lifelong, evolving response to loss rather than something to “get over.” She explains the differences between acute grief, integrated grief, and prolonged grief disorder, highlighting how factors like attachment, personal history, and circumstances of death can influence the grieving process. Glorioso outlines how prolonged grief can impair daily functioning and discusses effective treatments, including a structured therapy program that facilitates adaptation. She also examines resilience as a skill that can be strengthened through emotion regulation, cognitive flexibility, social support, and meaning-making. Drawing on both professional expertise and personal loss, Glorioso offers practical strategies for coping, supporting others, and finding hope while honoring the memory of loved ones. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40332]

Prostate Cancer Survivorship: Urinary and Sexual Wellness

Play Episode Listen Later Sep 25, 2025 22:38


Dr. Lindsay Hampson discusses urinary incontinence and sexual dysfunction following prostate cancer treatment, emphasizing that both are common and treatable. She explains the different types of incontinence—stress, urge, mixed, and overflow—and outlines how understanding the cause helps guide treatment. Options include pelvic floor physical therapy, medications, surgical interventions like slings or artificial sphincters, and supportive devices. Dr. Hampson also reviews effective strategies for managing erectile dysfunction, such as oral medications, vacuum devices, injections, and penile implants. She highlights the importance of shared decision-making and reassures patients that even small symptoms can significantly affect quality of life and deserve attention. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40814]

Scientists Find the BEST Lighting Color for Emotional Well-Being

Play Episode Listen Later Sep 22, 2025 3:36


Why does amber light ease stress and anxiety? One theory is that it's similar to the natural orange light experienced in nature, like sunsets and campfires. Thanks to interest and funding in color psychology research, discoveries like this will improve emotional and mental health for everyone, especially those who need it most like hospital patients and those in elder care housing. Series: "UC Davis News" [Health and Medicine] [Science] [Show ID: 41054]

Radiation Therapy for Oligometastatic Prostate Cancer

Play Episode Listen Later Sep 21, 2025 9:26


Radiologist Dr. Julian Hong plains how stereotactic body radiation therapy (SBRT) is used to treat oligometastatic prostate cancer—cases where cancer has spread but only to a few limited sites. This approach targets small clusters of metastases with high-dose, image-guided radiation in five or fewer sessions. Hong reviews clinical trial evidence showing that adding focal radiation can improve outcomes, especially when all visible metastases are treated. He highlights the value of modern imaging, like PET scans, in identifying lesions and shaping personalized treatment plans. Studies suggest SBRT offers effective disease control with low toxicity and minimal impact on quality of life, making it a promising option for patients with limited metastatic spread. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40807]

The History of Food: The Universalization of Regional Food Practices

Play Episode Listen Later Sep 17, 2025 57:19


Stanley Chodorow, Emeritus Professor of History at UC San Diego, traces the evolution of food preservation, preparation, and production from ancient times to the modern era. He explores early methods such as drying, salting, and ice cellars, advances like iceboxes, refrigeration, and flash freezing, and innovations in cooking technology from open fires to gas and electric stoves. Chodorow examines the domestication of animals, the development of agriculture, and transformative tools like the wheeled plow and horse harness. He highlights the rise of industrialized food, refrigerated transport, and global trade in products such as sugar, chocolate, and processed foods. Concluding with the health impacts of dietary changes since the shift from hunter-gatherer to agricultural societies, he offers a sweeping view of how technology has shaped what—and how—we eat. Series: "Osher UC San Diego Distinguished Lecture Series" [Health and Medicine] [Science] [Show ID: 40966]

The Hematopoietic Stem Cell Niche and Implications for Clinical Transplantation

Play Episode Listen Later Sep 15, 2025 54:22


Sean Morrison, Ph.D., from the Children's Medical Center Research Institute at UT Southwestern, investigates how stem cells function, regenerate, and interact with their surrounding environment in the bone marrow. His research reveals how leptin receptor-positive cells—key components of the bone marrow niche—regulate hematopoietic stem cell maintenance and regeneration, influence platelet production, and respond to physiological stress like pregnancy. Morrison uncovers a reciprocal relationship between these niche cells and peripheral nerves, showing that disrupting nerve signals impairs bone marrow recovery after chemotherapy or radiation. His work also links retrotransposon activation during pregnancy to increased red blood cell production, with implications for maternal health and transplant medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40449]

Treatment for Moyamoya Disease

Play Episode Listen Later Sep 15, 2025 7:35


UCSF stroke neurologist Dr. Anirudh Sreekrishnan and UCSF vascular neurosurgeon Dr. Luis Savastano describe Moyamoya disease, a rare condition where arteries at the base of the brain become narrowed or blocked, reducing blood flow. The name “moyamoya” means “puff of smoke” in Japanese, describing the tiny vessels that form to compensate. These fragile vessels can cause strokes or bleeding. Treatment often involves surgical procedures, such as direct or indirect revascularization, to restore blood flow and reduce stroke risk. Series: "UC San Francisco News" [Health and Medicine] [Show ID: 41036]

Overview: PSA Recurrent Prostate Cancer

Play Episode Listen Later Sep 15, 2025 32:08


Experts present new tools for managing PSA-recurrent prostate cancer. Dr. Steven Seyedin describes how PET/CT imaging enhances detection by reducing false positives and improving staging accuracy. Dr. Thomas Hope highlights PSMA PET imaging, now the standard approach, which identifies cancer more precisely by targeting tumor-specific proteins. Dr. Julian Hong discusses stereotactic body radiation therapy (SBRT) for patients with limited metastases, showing that it offers effective, low-toxicity treatment while preserving quality of life. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40867]

Cellular Reprogramming in Human Disease

Play Episode Listen Later Sep 13, 2025 58:25


Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]

Why Research Funding Matters: A Patient Perspective

Play Episode Listen Later Sep 11, 2025 1:15


Kimberly Peters, a stage four uterine cancer patient at UC San Diego Health, urges government leaders not to cut science funding. She warns that reduced federal support risks delaying vital research and life-saving cures. [Health and Medicine] [Show ID: 41071]

One Doctor's Journey Through the AIDS Epidemic

Play Episode Listen Later Sep 8, 2025 7:13


On his very first day at San Francisco General Hospital, Dr. Paul Volberding met his first AIDS patient – a moment that shaped his career and left an indelible mark on the fight against an epidemic. Now, more than 40 years later, Volberding reflects on the creation of Ward 86, the nation's first HIV clinics, and how UCSF's compassionate, community-first approach redefined HIV/AIDS care worldwide. The work of Volberding and UCSF's dedicated clinicians and scientists laid the foundation for advancements that continue to save lives today. [Health and Medicine] [Show ID: 40986]

Neuromodulation Pharmacogenetics and Imaging: Biological Approaches to Tailoring Therapy

Play Episode Listen Later Sep 7, 2025 42:19


As part of the 2025 Developmental Disabilities Conference, Dr. Elysa Marco talks about various biological approaches to therapy. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40623]

Sibling Support and Developmental Disabilities

Play Episode Listen Later Sep 1, 2025 41:53


As part of the 2025 Developmental Disabilities Conference, Emily Hill talks about how sibling support can be a catalyst for family empowerment. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40622]

Supported Healthcare Decision-Making for People with Developmental Disabilities

Play Episode Listen Later Aug 31, 2025 39:57


As part of the 2025 Developmental Disabilities Conference, Judy Mark, Vivian Do, Miguel Lugo, all from Disability Voices United, talk about supported decision-making in healthcare. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40611]

Active Surveillance for Early-Stage Prostate Cancer

Play Episode Listen Later Aug 30, 2025 14:45


Urologic oncologist Dr. Peter Carroll presents the latest research on active surveillance as a preferred approach for managing low-risk prostate cancer and selected cases of intermediate-risk disease. Drawing from two decades of UCSF data, he explains how long-term outcomes support the safety and effectiveness of delaying treatment for carefully monitored patients. Carroll emphasizes that surveillance decisions should be guided by MRI imaging, PSA density, cancer volume, histologic subtype, and genomic testing. He notes that while many men experience gradual changes over time, only a small percentage require immediate treatment. Carroll also discusses innovations such as AI-assisted pathology and risk profiling to reduce unnecessary procedures. His data-driven approach offers patients a personalized path that preserves quality of life without compromising outcomes. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40801]

Stem Cells and Next Generation Regenerative Medicine Therapies - Medicine Informing Novel Discoveries (MIND)

Play Episode Listen Later Aug 26, 2025 59:31


Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body's ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]

Introduction to Prostate Cancer

Play Episode Listen Later Aug 25, 2025 67:52


Prostate cancer remains the most commonly diagnosed cancer and second leading cause of cancer death among men in the U.S., with evolving screening and treatment practices reshaping care in 2025. Dr. Cornelia Ding explains how to read and understand a prostate cancer pathology report by breaking down its five key sections. Dr. Rahul Aggarwal explores how clinical trials improve prostate cancer care by advancing personalized treatment, increasing access, and correcting misconceptions about placebos. Dr. Jonathan Chou highlights the expanding role of precision medicine and how genetic insights guide individualized treatment based on each tumor's molecular makeup. Dr. Eric Small explains how androgen deprivation therapy (ADT) targets the cancer's dependence on testosterone and how newer therapies and combinations are improving outcomes, while also emphasizing the need to balance effectiveness with side effects through shared decision-making. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40865]

More on Localized Prostate Cancer

Play Episode Listen Later Aug 25, 2025 57:00


UCSF experts present four major approaches to managing prostate cancer, each tailored to disease risk and patient needs. Dr. Peter Carroll explains how active surveillance uses MRI, PSA, and genomic testing to safely delay treatment in low-risk cases while preserving quality of life. Dr. Samuel Washington details prostatectomy, highlighting robotic-assisted surgery's precision and its impact on recovery, fertility, and sexual function. Dr. Julian Hong outlines radiation therapy options like SBRT and brachytherapy, emphasizing targeted delivery to limit side effects and the importance of ongoing follow-up. Dr. Hao Nguyen introduces focal therapy, which treats only the tumor using techniques like cryotherapy or high-intensity ultrasound, helping patients avoid surgery or radiation while maintaining function and quality of life. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40866]

Reproductive Immunology

Play Episode Listen Later Aug 25, 2025 5:56


Ina Stelzer, Ph.D., explores how the maternal immune system adapts to support a healthy pregnancy and how disruptions can lead to complications like preterm birth. Her lab identifies early immune changes linked to spontaneous preterm birth and investigates the role of the maternal brain in regulating immune responses. Stelzer uses advanced technologies like mass cytometry and spatial proteomics to map immune and molecular changes in pregnancy, integrating these data with transcriptomics and mouse models. Her team studies how antidepressants affect immune signaling during pregnancy and examines the impact of social and behavioral factors. These insights may reveal biomarkers and therapeutic targets for improving maternal and fetal health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40773]

Glycobiology (GLOW)

Play Episode Listen Later Aug 22, 2025 13:40


Amanda Lewis, Ph.D. investigates how glycan-degrading enzymes contribute to bacterial vaginosis (BV), a common condition linked to infertility, preterm birth, pelvic inflammatory disease, and increased cancer risk. Her research shows that BV-associated bacteria strip protective sugar coatings—glycans—from vaginal epithelial cells, disrupting normal function and increasing vulnerability to infection. Lewis and her team study specific enzymes, such as sialidases, that remove sialic acid from glycoproteins and mucins. Using clinical samples and imaging techniques, they identify how these changes in glycan composition correlate with disease severity. Their work reveals how glycan degradation contributes to persistent or recurrent BV and opens new pathways for understanding the microbiome's role in women's health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40678]

Intermittent Fasting: A Strategy To Prevent Cardiometabolic Diseases And Promote Healthy Aging

Play Episode Listen Later Aug 22, 2025 54:24


Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explores the science and clinical evidence behind intermittent fasting and its role in promoting cardiometabolic health. He explains how aligning eating patterns with the body's natural circadian rhythms can improve weight, blood pressure, glucose regulation, and other risk factors, especially in individuals with metabolic syndrome or type 2 diabetes. Wilkinson highlights promising results from time-restricted eating studies conducted in collaboration with UC San Diego and the Salk Institute, where narrowing the daily eating window led to improved metabolic markers and potential benefits beyond weight loss. He also outlines practical tips for safely adopting this lifestyle approach and stresses the importance of ongoing research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40319]

Immunotherapy and Prostate Cancer

Play Episode Listen Later Aug 21, 2025 11:08


Immunotherapy expert Dr. David Oh explains how the immune system can be trained to recognize and fight prostate cancer. He outlines key immune players—dendritic cells and T cells—and describes how immunotherapies target different stages of their interaction with tumors. Oh highlights FDA-approved treatments such as Provenge, a vaccine made from a patient's own cells, and PD-1 checkpoint inhibitors for patients with specific genetic mutations like microsatellite instability. He also discusses potential autoimmune side effects and emphasizes the importance of genetic testing. Looking ahead, he introduces bispecific T-cell engagers, experimental therapies that physically link T cells to tumors, triggering an immune attack. These promising treatments offer new hope, especially for men with advanced, treatment-resistant prostate cancer. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40811]

A Closer Look at…Genetic Medicine and Artificial Intelligence

Play Episode Listen Later Aug 19, 2025 57:59


AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

Supporting Immigrant Children with Special Health Care Needs

Play Episode Listen Later Aug 18, 2025 39:05


As part of the 2025 Developmental Disabilities Conference, Dr. Raul Gutierrez, Associate Professor of Pediatrics at San Francisco General Hospital, talks about supporting immigrant children. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40619]

Radiation Therapy for Localized Prostate Cancer

Play Episode Listen Later Aug 18, 2025 13:50


Radiation oncologist Dr. Julian Hong explains how radiation therapy works and its central role in treating prostate cancer, both when the disease is localized and when it has spread to limited areas. He outlines major radiation options, including external beam radiation, stereotactic body radiation therapy (SBRT), and brachytherapy, and describes how treatment plans are carefully tailored using imaging, planning scans, and computer modeling to maximize precision and minimize side effects. Hong highlights advances in targeting and beam modulation, which allow for safer, more effective treatment. He also discusses typical timelines for treatment, short- and long-term side effects, and the importance of ongoing follow-up to manage late effects of therapy. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40803]

Imaging in Gynecologic Disorders

Play Episode Listen Later Aug 18, 2025 14:54


Rebecca Rakow Penner, M.D., Ph.D., is a body and breast imaging radiologist and MRI physicist advancing how pelvic pain and gynecologic cancers are diagnosed through imaging. She highlights how MRI is improving the detection of endometriosis, pelvic adhesions, venous disorders, and pelvic floor dysfunction with enhanced resolution and motion-sensitive techniques. Rakow Penner also works on new MRI-based protocols that may reduce the need for contrast agents in evaluating breast and ovarian cancer. Through innovative modeling techniques like restriction spectrum imaging, she explores how to differentiate cancerous tissue from post-treatment effects, aiming to improve treatment assessment for cervical and ovarian cancer. Her collaborations span clinical, engineering, and pathology teams. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40673]

Managing Obesity with New Medications

Play Episode Listen Later Aug 15, 2025 57:06


Dr. Robert Baron explores current strategies for treating obesity, emphasizing evidence-based approaches to diagnosis, lifestyle change, medication, and long-term weight maintenance. He explains the limitations of body mass index (BMI) as a diagnostic tool and highlights the importance of assessing both excess fat and its health consequences. He reviews dietary principles, including calorie reduction, avoiding added sugars, and the importance of sustainable habits over specific diet types. He also discusses the role of physical activity—particularly strength training—for preserving muscle and improving long-term outcomes. Baron evaluates weight loss medications such as semaglutide and tirzepatide, noting their benefits, side effects, and the need for continued use to maintain weight loss. [Health and Medicine] [Show ID: 40757]

Enhancing the Health of Adults with Disabilities in Community Fitness Facilities

Play Episode Listen Later Aug 13, 2025 34:16


As part of the 2025 Developmental Disabilities Conference, Allen Friedland, Terri Hancharick and Jack Jadach talk about a collaborative approach to enhancing health in fitness centers. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40613]

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