University of California Audio Podcasts (Audio)

Chronic pain in older adults can affect mobility, mood, sleep, social connection, and independence. Una Makris, M.D., M.Sc., UC San Diego and VA San Diego Healthcare System, explains why musculoskeletal pain is common later in life and why medications or procedures alone may not meet the needs of many patients. Drawing on her work in rheumatology and geriatrics, Makris describes how pain and depression can reinforce each other, making it important to address both together. She highlights an age-friendly behavioral coaching approach that uses motivational interviewing, values-based goal setting, physical activity, and social support to help people reconnect with meaningful activities. By focusing on small, safe increases in movement, this research points to practical ways to support better function, quality of life, and healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41172]

As part of the 2026 Developmental Disabilities Conference, Corinne Melon, Managing Director, Phamaly Theatre Company, talks about accessible theater for people with disabilities. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41468]

As part of the 2026 Developmental Disabilities Conference, Chantel Burkitt, Senior Clinical Scientist, and Todd Dalberg, Pediatrician and Palliative Medicine Physician, Gilette Children's Hospital, discuss how to assess and manage pain for people with developmental disabilities. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41471]

Authentic autism representation begins with listening to autistic people and including them in stories about their lives. Seth Bakke, producer, writer and director of The Rescue, explains how his autistic cousin Aaron and a poem by autistic typer Peter Tran inspired the film. Bakke describes working with Aaron on screen, consulting the Tran family and adapting the set to support his needs. Autistic typers Otto Lana and Peter Tran, joined by Steven Tran, a postdoctoral researcher at UC San Diego, discuss where the film reflects their experiences, where it simplifies communication through typing and why creative freedom must remain grounded in lived experience. They address presuming competence, the difference between hearing and listening, and the need for autistic actors and advisers. Their participation challenges stereotypes and helps audiences see they should be full participants in their own stories. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Arts and Music] [Show ID: 41175]

Scientific progress depends on curiosity, investment and the freedom to take risks. Nobel Laureate and UC San Diego alumnus Fred Ramsdell traces his path from community college to biotechnology and a discovery that reshaped understanding of immune regulation. He explains how decades of publicly funded research made that breakthrough possible and why failed experiments are essential steps toward discovery. Ramsdell discusses threats to federal research funding, the private sector's limited tolerance for risk and the need for scientists to communicate clearly. Rebuilding trust, he argues, starts with listening, finding shared values and explaining how basic research leads to new treatments, economic value and national security. Sustained support for science matters because no one can predict where the next major breakthrough will begin. Series: "Deep Look Public Speaker Series" [Science] [Show ID: 41113]

Climate and environmental change affect reproductive health and pregnancy in important ways. Dr. Marya Zlatnik explains how petrochemicals, climate change, and everyday chemical exposures can shape reproductive resilience and pregnancy outcomes. Zlatnik helps clarify how people can protect reproductive well-being in a changing climate with informed, resilience-building choices. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 41547]

As part of the 2026 Developmental Disabilities Conference, Dr. Althea Robinson Shelton, Associate Professor of Neurology and Pediatrics, Vanderbilt University Medical Center, discusses sleep in children with neurodevelopmental differences. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41466]

As part of the 2026 Developmental Disabilities Conference, moderator Judy Mark and panelists Elizabeth Barrios Gomez, Mulugeta Tadele, Kyungshil Choi discuss the challenges and solutions for serving immigrant clients. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41467]

What is a decision, and why does decision-making matter in politics, history, war, and public life? This panel examines how decisions differ from choices, when decisions become political, and how theories of rational choice, game theory, cognitive bias, neuroscience, and emotion shape our understanding of judgment. They explore how constitutional, legal, cultural, and social frameworks influence government decision-making, with special attention to decisions for or against war. And they trace how history uses moments of decision to explain sovereignty, leadership, democracy, authoritarianism, and crises such as climate change. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Show ID: 41450]

Decision-making in history affects how societies understand power, responsibility, and change. Sir Christopher Clark, Regius Professor of History at the University of Cambridge, explains how narratives turn moments of decision into markers of sovereignty and political action. Clark examines real and ostensible decisions, deterministic political environments, and modern pressures from democracy, authoritarianism, and climate change, helping clarify why deciding can become harder over time. This work helps explain how historical narratives shape political judgment and points toward a more careful understanding of choice, power, and consequence. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Show ID: 41449]

Political decision-making affects governments and societies in important ways. Sir Christopher Clark, Regius Professor of History at the University of Cambridge, explains how choices become decisions within political, legal, and cultural systems. Clark examines rational choice theory, cognitive bias, and decisions about war, helping clarify how power acts under pressure. This work helps explain why decisions are never purely abstract and points toward a richer understanding of political judgment. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Show ID: 41448]

Menopause and healthy aging affect women's health and well-being in important ways. Dr. Tami Rowen explains how the best available evidence shapes menopausal management, with a focus on the data and safety around hormone therapy. Dr. Riley Bove examines brain, heart, gynecological, bone, and emotional health during the postmenopausal years, helping clarify how women can support health in this next phase of life. This work helps explain why evidence-based care matters and points toward practical strategies for healthy aging. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 41548]

As part of the 2026 Developmental Disabilities Conference, Dr. Bhooma Aravamuthan, Medical and Research Director, Cerebral Palsy and Mobility Center, Washington University in St. Louis, discusses evidence-based approaches for treating spasticity and dystonia management. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41464]

As part of the 2026 Developmental Disabilities Conference, Jane Tobias, Associate Professor, Jefferson College of Nursing, discusses environmental health for children with disabilities. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41465]

Art can connect personal history, community, and social change. Janelle Iglesias, Assistant Professor of Studio Art at UC San Diego, traces her path from a multicultural childhood in Queens to anthropology, ceramics, sculpture, and public art. She explains how objects in her family home sparked an interest in material culture, and how a reconciliation program in South Africa changed her view of what artists can contribute to society. Iglesias also describes nearly two decades of collaboration with her sister Lisa through Las Hermanas Iglesias, including projects involving their mother. Her teaching emphasizes play, curiosity, resourcefulness, and the idea that sculpture can be made from almost anything. By linking creative practice with care, connection, and community, Iglesias shows how art can help people respond to uncertainty and imagine more equitable futures. Series: "Mi Universidad " [Arts and Music] [Education] [Show ID: 41254]

With the success of Artemis II, NASA is preparing for humanity's return to the Moon through the ambitious Artemis Project. In this lecture, Professor Neil Farber explores the future Artemis missions, the spacecraft and technologies designed to support them, and the challenges NASA faces in sending astronauts back to the lunar surface. Building on the legacy of the Apollo program, Artemis represents a new era of exploration focused not only on reaching the Moon, but on establishing a sustainable long-term presence and preparing for future missions to Mars. Professor Farber examines why returning to the Moon today presents more difficulties than during the Apollo era, including modern engineering demands, funding realities, mission complexity, astronaut safety, and the logistical challenges of deep space travel. The lecture also highlights how NASA's goals have evolved since Apollo and why the Moon remains central to the future of human space exploration. Series: "Osher UC San Diego Distinguished Lecture Series" [Science] [Show ID: 41597]

As part of the 2026 Developmental Disabilities Conference, moderator Megan Cvitanovic leads a discussion with panelists Zorahida Preciado, Colette Patt, and Mechelle Johnson about resources for people with developmental disabilities who are living with aging parents. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41460]

Human brain organoids help researchers study neurodevelopmental disorders that are difficult to examine directly in developing brain tissue. Giorgia Quadrato, USC, uses cortical organoids derived from human pluripotent stem cells to examine SYNGAP1, an autism risk gene associated in the transcript with intellectual disability, epilepsy, and global developmental delay. Quadrato describes how SYNGAP1 appears in progenitor cells as well as neurons, and how SYNGAP1 haploinsufficiency is linked to disrupted radial glia organization, altered cell division, and faster maturation of cortical projection neurons. She also discusses newer work focused on enteric neurons, gastrointestinal symptoms, and gut motility. By connecting brain development, autism genetics, and the enteric nervous system, this research points to models that may help test therapies and better understand symptoms that affect families. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 41174]

As chatbots trained on Large Language Models become more sophisticated, their responses can sometimes seem uncanny, as if they come from a source that is mysterious, inexplicable, or even divine. Webb Keane, Professor of Anthropology at the University of Michigan, examines what happens when people treat artificial intelligence as a kind of “metahuman.” He explains how this reflects a broader human tendency to project authority onto technologies we do not fully understand. Keane explores how that sense of authority emerges through social interaction, and how the unequal ways humans and metahumans address one another can make AI's power feel intuitively real. Series: "Ethics, Religion and Public Life: Walter H. Capps Center Series" [Humanities] [Science] [Show ID: 41542]

As part of the 2026 Developmental Disabilities Conference, California State Senator Scott Wiener discusses healthcare access. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41455]

As part of the 2026 Developmental Disabilities Conference, Dr. Peter Bulova, Professor of General Internal Medicine, The University of Pittsburgh, discusses dementia in people with Down Syndrome. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41458]

Rome survived for 2,000 years. Edward Watts explores the long history of the Roman state and the lessons it offers for the modern world. From its beginnings as a small Italian city-state to its transformation into a Christian empire centered in Constantinople, Rome maintained a remarkable sense of political continuity across centuries of cultural and religious change. Watts examines how Roman institutions adapted over time and how the Fourth Crusade and capture of Constantinople ultimately destroyed the foundations that sustained the state for generations. Watts highlights the importance of resilient institutions and the dangers of disrupting the systems that preserve political stability and continuity. Series: "Osher UC San Diego Distinguished Lecture Series" [Public Affairs] [Humanities] [Show ID: 41602]

Hard optimization problems often look impossible through worst-case analysis, but real-world problems can contain structure that helps algorithms work faster. Ellen Vitercik, Ph.D., of Stanford University explains how machine learning can improve algorithm design for NP-hard optimization problems while preserving the formal guarantees that make solvers useful. She discusses beyond worst-case analysis, problem-specific heuristics, and the gap between tools that perform well in practice and methods that prove optimality. Vitercik also describes research on LLM reasoning using data structure tasks, where answers can be checked programmatically and failures reveal when models rely on pattern matching rather than true generalization. Her work helps clarify how AI may support stronger algorithms, more useful benchmarks, and more reliable reasoning systems. Series: "Data Science Channel" [Science] [Show ID: 41179]

Heart regeneration faces two connected challenges: replacing lost muscle and keeping transplanted cells safe and accepted by the body. Charles Murry, M.D., Ph.D., of USC explains why the adult heart heals major cardiomyocyte loss with scar tissue rather than new muscle, leading to progressive heart failure. Murry describes how stem cell derived cardiomyocytes can be manufactured at scale, transplanted into injured hearts, and tested for function in animal models. He also examines major barriers, including graft related arrhythmias, calcium handling stress, immune rejection, and the need for practical immunosuppression or immune edited cells. By connecting cell manufacturing, electrophysiology, immunology, and clinical trial planning, this research shows why heart regeneration is difficult and why careful translation matters for patients with severe heart injury. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40853]

Fertility health affects conception and reproductive planning in important ways. Jennifer Ashby, DAOM, and Maren Shapiro, MD, explain how East Asian medicine principles and daily habits shape fertility optimization. Ashby examines Jing, Blood, Qi, Yin/Yang balance, and stress, while Shapiro examines sleep, nutrition, exercise, supplements, timing intercourse, and when to seek additional support, helping clarify how the body can be supported before pregnancy. This work helps explain conception readiness and points toward practical strategies for reproductive health. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 41546]

In an age obsessed with expertise, certainty, and endless self-optimization, author and journalist Simone Stolzoff invites audiences to rediscover the power of curiosity, humility, and not having all the answers. His new book, How to Not Know, challenges the cultural pressure to define ourselves by what we do or what we know—and instead celebrates the richness of uncertainty as a pathway to creativity, empathy, and authentic connection. [Public Affairs] [Humanities] [Show ID: 41267]

As part of the 2026 Developmental Disabilities Conference, Dr. Paul Glassman, Professor and Associate Dean for Research and Community Engagement, College of Dental Medicine, California Northstate University, discusses dental care for people with developmental disabilities. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41462]

As part of the 2026 Developmental Disabilities Conference, Kavitha Murthi,Assistant Professor, Rutgers University, discusses occupational therapy for autistic people. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41463]

Hematopoietic stem cells make blood across the lifespan, but they do not all behave the same way. Stephanie Xie, Ph.D., Scientist at Princess Margaret Cancer Centre, University of Toronto, examines how these rare cells self-renew, differentiate, and respond to inflammatory stress, asking whether differences in the stem cell pool help explain why aging affects people so differently. Xie identifies two hematopoietic stem cell subsets, including one that retains inflammatory memory after stress recovery, and connects this state to aging, clonal hematopoiesis, sickle cell disease, post-COVID recovery, and mortality risk markers in blood. Her research also raises questions about whether targeting the inflammatory environment, including through GLP-1 receptor agonists or metformin, could help mitigate clonal hematopoiesis. Understanding these patterns could clarify how inflammation shapes blood production, cancer risk, and immune health over time. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41406]

Adolescent health affects the well-being of teen girls in important ways. Dr. Jenifer Matthews and Dr. David Becker explain how hormonal change and emerging technology shape physical and mental health. Matthews examines acne, PMS, and menstrual cycle irregularities, and offers integrative approaches to supporting teen hormonal balance, including key nutritional strategies and simple, safe herbal medicine options. Becker considers social media, AI companions, and integrative mental health care, helping clarify how teens can be supported through rapid change. This work helps explain common adolescent challenges and points toward practical, whole-person strategies. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 41545]

As part of the 2026 Developmental Disabilities Conference, Claudia Center, Legal Director, Disability Rights Education and Defense Fund talks about the health policy landscape. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41453]

As part of the 2026 Developmental Disabilities Conference, Tamar Heller, Director, Institute on Disability and Human Development, University of Illinois Chicago, discusses aging and aging caregivers. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41459]

Rare disease research is creating new paths for diagnosis, treatment, and broader medical discovery. Gene therapy can repair or replace faulty genes, and work on cystinosis has led to a stem cell platform now being applied to Danon disease, Sanfilippo syndrome C, Friedreich's ataxia, and Alzheimer's research. Funding programs support gene therapy, clinical trials, and new platform approaches for rare diseases. CAR-T cell research is also advancing treatment possibilities for pediatric brain tumors, including early results in children with DIPG and diffuse midline glioma. A patient advocate shares her daughter's diagnostic odyssey and treatment for TUBB4A leukodystrophy. Together, these stories show why rare disease research matters beyond rarity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41402]

Health data affects artificial intelligence in important ways. Camille Nebeker, Ed.D., M.S., UC San Diego, explains why ethically sourced data is foundational to building trustworthy, AI-ready health data repositories. Nebeker examines how ethical sourcing applies across the full data lifecycle, including consent, governance, transparency, data quality, privacy, stewardship, and community engagement. She also shows how ideas from supply chain management and value sensitive design help teams identify ethical tensions and improve decision-making. This work helps explain why ethics cannot be added at the end of AI development and points toward more accountable data practices that support public trust and stronger downstream performance. Series: "Exploring Ethics" [Science] [Show ID: 41368]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Steven Seyedin discusses radiation therapy. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41558]

Pre-cancer and cancer can begin when stressed blood-forming stem cells lose their normal controls. Catriona Jamieson, M.D., Ph.D., UC San Diego, explains how inflammation-linked editing enzymes, repetitive elements in the genome, and stem cell stress shape the progression from myeloproliferative neoplasms to acute myeloid leukemia. Jamison examines how spaceflight accelerates stem cell aging, how some astronauts mobilize a resilient regenerative stem cell population, and how tumor organoids in space help reveal drug responses by activating the enzyme ADAR1. This work helps explain how cancer starts, why it can return, and how space-based research may speed the development of therapies that stop malignant stem cells before disease advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41473]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Spencer Behr discusses PSMA PET and functional imaging. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41557]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Jonathan Chou discusses targeted therapies. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41563]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. David Oh discusses immunotherapy. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41562]

What does it mean to rethink religion from the ground up? University of Colorado's religious studies professor Sam Gill draws on biology, philosophy, and decades of research and dance practice to argue that we are moving, whole organisms before we are divided into mind and body. Gill proposes that humans possess a biologically enabled capacity to hold together what we know to be different as if it were the same—a dynamic that underlies the powers of metaphor, masking, dancing, ritual action, symbol, and language. Through vivid examples from Hopi initiation, Javanese shadow puppetry and dance, and Navajo prayer ceremonials, Gill shows how religious actions create worlds, identities, and enduring cultural coherence. Series: "Ethics, Religion and Public Life: Walter H. Capps Center Series" [Humanities] [Show ID: 41541]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Stacey Kenfield, ScD, discusses diet and exercise. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41555]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Will Chen discusses PET-directed radiation for Oligometastatic Disease. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41559]